CLPTM1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.10552236
2COPI coating of Golgi vesicle (GO:0048205)7.10552236
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.61125929
4protein retention in ER lumen (GO:0006621)5.19575546
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07146332
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07146332
7mitotic chromosome condensation (GO:0007076)4.99609397
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.80342806
9positive regulation of nuclease activity (GO:0032075)4.63339783
10nuclear pore complex assembly (GO:0051292)4.59527811
11COPII vesicle coating (GO:0048208)4.41527622
12antigen processing and presentation of endogenous antigen (GO:0019883)4.36773182
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.32361190
14endoplasmic reticulum unfolded protein response (GO:0030968)4.30794204
15DNA unwinding involved in DNA replication (GO:0006268)4.17864205
16regulation of nuclease activity (GO:0032069)4.17168986
17cellular protein complex localization (GO:0034629)4.17141930
18cellular response to unfolded protein (GO:0034620)4.13589921
194-hydroxyproline metabolic process (GO:0019471)4.11534521
20ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.01961134
21ER-nucleus signaling pathway (GO:0006984)3.99673263
22cysteine metabolic process (GO:0006534)3.99294205
23regulation of translational fidelity (GO:0006450)3.99018441
24exocrine pancreas development (GO:0031017)3.92361282
25cellular response to topologically incorrect protein (GO:0035967)3.90615838
26nuclear pore organization (GO:0006999)3.84198487
27intestinal cholesterol absorption (GO:0030299)3.83544741
28valine metabolic process (GO:0006573)3.82685822
29protein complex localization (GO:0031503)3.77579163
30protein maturation by protein folding (GO:0022417)3.76872631
31signal peptide processing (GO:0006465)3.73840735
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67356156
33L-phenylalanine catabolic process (GO:0006559)3.67356156
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61051465
35L-phenylalanine metabolic process (GO:0006558)3.61051465
36response to endoplasmic reticulum stress (GO:0034976)3.56471138
37sulfur amino acid catabolic process (GO:0000098)3.56271515
38activation of Rac GTPase activity (GO:0032863)3.55933372
39gonadal mesoderm development (GO:0007506)3.51924044
40folic acid metabolic process (GO:0046655)3.49975133
41alpha-linolenic acid metabolic process (GO:0036109)3.45800752
42pore complex assembly (GO:0046931)3.42709923
43vesicle coating (GO:0006901)3.40894927
44formation of translation preinitiation complex (GO:0001731)3.40888707
45lysine catabolic process (GO:0006554)3.40760537
46lysine metabolic process (GO:0006553)3.40760537
47apoptotic cell clearance (GO:0043277)3.39879434
48peptidyl-asparagine modification (GO:0018196)3.29138126
49protein N-linked glycosylation via asparagine (GO:0018279)3.28914500
50cellular modified amino acid catabolic process (GO:0042219)3.26843601
51nucleobase-containing small molecule interconversion (GO:0015949)3.25831240
52DNA replication initiation (GO:0006270)3.23711352
53mitotic sister chromatid segregation (GO:0000070)3.22481411
54peptidyl-glutamic acid carboxylation (GO:0017187)3.21698397
55protein carboxylation (GO:0018214)3.21698397
56UDP-N-acetylglucosamine metabolic process (GO:0006047)3.18010092
57response to unfolded protein (GO:0006986)3.17969538
58pentose-phosphate shunt (GO:0006098)3.16238243
59regulation of translational termination (GO:0006449)3.15823462
60complement activation, classical pathway (GO:0006958)3.15291355
61DNA strand elongation involved in DNA replication (GO:0006271)3.15190622
62apoptotic process involved in morphogenesis (GO:0060561)3.14998566
63DNA strand elongation (GO:0022616)3.13137266
64spliceosomal tri-snRNP complex assembly (GO:0000244)3.12883503
65desmosome organization (GO:0002934)3.11094587
66focal adhesion assembly (GO:0048041)3.10756509
67cell-substrate adherens junction assembly (GO:0007045)3.10756509
68sequestering of metal ion (GO:0051238)3.10260376
69ribosomal small subunit biogenesis (GO:0042274)3.09904414
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09559076
71transcytosis (GO:0045056)3.07660476
72response to topologically incorrect protein (GO:0035966)3.06848585
73positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.06722304
74protein localization to endosome (GO:0036010)3.04914341
75adherens junction assembly (GO:0034333)3.03528234
76protein N-linked glycosylation (GO:0006487)3.02276046
77regulation of early endosome to late endosome transport (GO:2000641)3.01153341
78mitotic sister chromatid cohesion (GO:0007064)2.95981656
79tricarboxylic acid metabolic process (GO:0072350)2.91665570
80regulation of cholesterol homeostasis (GO:2000188)2.90660963
81homocysteine metabolic process (GO:0050667)2.89218741
82nitrogen cycle metabolic process (GO:0071941)2.88966607
83sister chromatid segregation (GO:0000819)2.86819286
84low-density lipoprotein particle clearance (GO:0034383)2.86663676
85triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86336825
86NADPH regeneration (GO:0006740)2.85445117
87complement activation, alternative pathway (GO:0006957)2.85198993
88aromatic amino acid family catabolic process (GO:0009074)2.85042931
89negative regulation of fibrinolysis (GO:0051918)2.84766701
90complement activation (GO:0006956)2.83425130
91chromosome condensation (GO:0030261)2.82906438
92cell-substrate junction assembly (GO:0007044)2.82763739
93L-alpha-amino acid transmembrane transport (GO:1902475)2.82741047
94protein localization to chromosome, centromeric region (GO:0071459)2.81848653
95regulation of protein activation cascade (GO:2000257)2.80734859
96antigen processing and presentation via MHC class Ib (GO:0002475)2.80504895
97intestinal absorption (GO:0050892)2.79554261
98oxaloacetate metabolic process (GO:0006107)2.79101127
99epithelial cell-cell adhesion (GO:0090136)2.77515461
100GDP-mannose metabolic process (GO:0019673)2.74682967
101mitotic nuclear envelope disassembly (GO:0007077)2.74164108
102regulation of complement activation (GO:0030449)2.73918091
103positive regulation of DNA-dependent DNA replication (GO:2000105)2.73653260
104positive regulation of Cdc42 GTPase activity (GO:0043089)2.73348286
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73006268
1062-oxoglutarate metabolic process (GO:0006103)2.72303562
107hemidesmosome assembly (GO:0031581)2.71504236
108basement membrane organization (GO:0071711)2.71419447
109maternal placenta development (GO:0001893)2.71019102
110RNA stabilization (GO:0043489)2.68285947
111mRNA stabilization (GO:0048255)2.68285947
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.67160561
113regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67110761
114protein export from nucleus (GO:0006611)2.66392134
115regulation of RNA export from nucleus (GO:0046831)2.66099367
116protein autoprocessing (GO:0016540)2.66008184
117telomere maintenance via semi-conservative replication (GO:0032201)2.65834139
118peptidyl-proline hydroxylation (GO:0019511)2.64969328
119drug transmembrane transport (GO:0006855)2.64434893
120DNA duplex unwinding (GO:0032508)2.63648214
121membrane disassembly (GO:0030397)2.62217900
122nuclear envelope disassembly (GO:0051081)2.62217900
123proline biosynthetic process (GO:0006561)2.61598923
124embryonic process involved in female pregnancy (GO:0060136)2.59858271
125positive regulation of keratinocyte differentiation (GO:0045618)2.59655682
126mannose metabolic process (GO:0006013)2.59086966
127proline metabolic process (GO:0006560)2.58934594
128glyoxylate metabolic process (GO:0046487)2.57559536
129regulation of histone H3-K27 methylation (GO:0061085)2.57270427
130mitochondrial DNA metabolic process (GO:0032042)2.53090909
131regulation of nucleobase-containing compound transport (GO:0032239)2.53004032
132regulation of fatty acid beta-oxidation (GO:0031998)2.52889307
133kynurenine metabolic process (GO:0070189)2.52882643
134high-density lipoprotein particle remodeling (GO:0034375)2.52845833
135urea metabolic process (GO:0019627)2.52161440
136urea cycle (GO:0000050)2.52161440
137nuclear envelope organization (GO:0006998)2.50569906
138reverse cholesterol transport (GO:0043691)2.49347394
139plasma lipoprotein particle clearance (GO:0034381)2.49013543
140cell redox homeostasis (GO:0045454)2.48803904
141glucose catabolic process (GO:0006007)2.48195523
142positive regulation of triglyceride biosynthetic process (GO:0010867)2.47927872
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47795982
144ribosome biogenesis (GO:0042254)2.47013400
145pinocytosis (GO:0006907)2.46857154
146bile acid biosynthetic process (GO:0006699)2.46731795
147mitotic nuclear envelope reassembly (GO:0007084)2.46554609
148nuclear envelope reassembly (GO:0031468)2.46554609
149tyrosine metabolic process (GO:0006570)2.45484599
150positive regulation of triglyceride metabolic process (GO:0090208)2.45289387
151negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45172481
152negative regulation of cell size (GO:0045792)2.45074970
153regulation of mitotic spindle organization (GO:0060236)2.44730789
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.44456837
155hormone catabolic process (GO:0042447)2.43343127
156acute-phase response (GO:0006953)2.43077116
157negative regulation of cholesterol transport (GO:0032375)2.43075221
158negative regulation of sterol transport (GO:0032372)2.43075221
159establishment of apical/basal cell polarity (GO:0035089)2.42913455
160zinc ion transport (GO:0006829)2.42849016
161protein activation cascade (GO:0072376)2.41055814
162DNA geometric change (GO:0032392)2.40497107
163ER to Golgi vesicle-mediated transport (GO:0006888)2.40239579
164regulation of fibrinolysis (GO:0051917)2.40111721
165glutamine family amino acid biosynthetic process (GO:0009084)2.40111449
166midgut development (GO:0007494)2.39531970
167ribonucleoprotein complex biogenesis (GO:0022613)2.38925459
168tRNA methylation (GO:0030488)2.38913526
169response to laminar fluid shear stress (GO:0034616)2.38868497
1703-UTR-mediated mRNA stabilization (GO:0070935)2.38690928
171atrioventricular valve morphogenesis (GO:0003181)2.38395457
172DNA packaging (GO:0006323)2.37865923
173Golgi organization (GO:0007030)2.37650596
174macroautophagy (GO:0016236)2.36785240
175ethanol oxidation (GO:0006069)2.36215522
176heterochromatin organization (GO:0070828)2.35436775
177regulation of plasminogen activation (GO:0010755)2.35334628
178skin morphogenesis (GO:0043589)2.34755646
179glucocorticoid receptor signaling pathway (GO:0042921)2.34288759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.75559061
2E2F7_22180533_ChIP-Seq_HELA_Human5.53316019
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.96972740
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.67366158
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.59749963
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.08463760
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.01277170
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75987767
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.74658926
10CLOCK_20551151_ChIP-Seq_293T_Human2.49592940
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.44842626
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41743704
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32245682
14* MYC_22102868_ChIP-Seq_BL_Human2.24382461
15GATA1_22025678_ChIP-Seq_K562_Human2.23674388
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.21834436
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17076314
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12860748
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04967347
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02560441
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01605908
22* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99704211
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97846861
24LXR_22292898_ChIP-Seq_THP-1_Human1.93639158
25ZNF263_19887448_ChIP-Seq_K562_Human1.84901107
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82145352
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81332667
28AR_21909140_ChIP-Seq_LNCAP_Human1.76922554
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76895715
30VDR_21846776_ChIP-Seq_THP-1_Human1.75082913
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74273766
32* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72252916
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71811460
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.68308566
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65567148
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65565993
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64957879
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.64525507
39* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62985537
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62955897
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62476686
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59539922
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56139771
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.55198008
45* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52746638
46XRN2_22483619_ChIP-Seq_HELA_Human1.52516722
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52404367
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52076754
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51611823
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51177793
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49348923
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47455609
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46288163
54TCF7_22412390_ChIP-Seq_EML_Mouse1.45868568
55* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45356024
56* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44662802
57RACK7_27058665_Chip-Seq_MCF-7_Human1.43709372
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41882526
59MAF_26560356_Chip-Seq_TH1_Human1.40829122
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39882140
61VDR_24763502_ChIP-Seq_THP-1_Human1.39614617
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37941444
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37936704
64UTX_26944678_Chip-Seq_JUKART_Human1.36624879
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.35449469
66DCP1A_22483619_ChIP-Seq_HELA_Human1.35148637
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34514111
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32908769
69* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32429693
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31339911
71* ATF3_27146783_Chip-Seq_COLON_Human1.31275425
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.31206920
73* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30715031
74* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30700631
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29160148
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28893029
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27511997
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.26563371
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.25159162
80MYB_26560356_Chip-Seq_TH2_Human1.24350636
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24316343
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22865695
83KDM2B_26808549_Chip-Seq_DND41_Human1.22206833
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21984622
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20610403
86KDM5A_27292631_Chip-Seq_BREAST_Human1.20005207
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.19824227
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19312658
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18999434
90* SMC4_20622854_ChIP-Seq_HELA_Human1.18857378
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18591461
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17806183
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17679973
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16432290
95* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15311133
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14918038
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14423450
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14012042
99GATA4_25053715_ChIP-Seq_YYC3_Human1.12462642
100MYB_26560356_Chip-Seq_TH1_Human1.11923184
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11162499
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10948687
103* RUNX1_22412390_ChIP-Seq_EML_Mouse1.10774946
104* P68_20966046_ChIP-Seq_HELA_Human1.09686478
105* KDM2B_26808549_Chip-Seq_K562_Human1.09192599
106GATA6_25053715_ChIP-Seq_YYC3_Human1.09184793
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08804817
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08468639
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08412254
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06432445
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05757837
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.05379150
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.04828164
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04298513
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04022699
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.03521454
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03457062
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03310985
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03130778
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03013675
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02588488
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01731186
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00963933
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00453889
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99326241
126GATA3_27048872_Chip-Seq_THYMUS_Human0.98804256
127GATA1_19941826_ChIP-Seq_K562_Human0.98399776
128IRF8_21731497_ChIP-ChIP_J774_Mouse0.95871179
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95601340
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95505825
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95505825
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94898047
133NCOR1_26117541_ChIP-Seq_K562_Human0.94513345
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94178305
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.94109863
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94105669
137CTCF_21964334_Chip-Seq_Bcells_Human0.93273427
138CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93119970
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92997298
140MAF_26560356_Chip-Seq_TH2_Human0.92751366
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92256081
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92062581
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.91235600
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90627475
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90319166
146SPI1_23127762_ChIP-Seq_K562_Human0.89943921
147CREB1_26743006_Chip-Seq_LNCaP_Human0.89459115
148SPI1_23547873_ChIP-Seq_NB4_Human0.89078540
149TFEB_21752829_ChIP-Seq_HELA_Human0.89029305
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87450149
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87310120
152RUNX1_27514584_Chip-Seq_MCF-7_Human0.87096810
153CHD1_26751641_Chip-Seq_LNCaP_Human0.86977650
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86775042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.58808290
2MP0005365_abnormal_bile_salt3.58695801
3MP0005360_urolithiasis3.25223931
4MP0001666_abnormal_nutrient_absorption3.05010412
5MP0005085_abnormal_gallbladder_physiolo2.98590958
6MP0010234_abnormal_vibrissa_follicle2.98145865
7MP0003300_gastrointestinal_ulcer2.94979196
8MP0005076_abnormal_cell_differentiation2.89411979
9MP0005083_abnormal_biliary_tract2.72067547
10MP0005451_abnormal_body_composition2.65164973
11MP0004233_abnormal_muscle_weight2.59161462
12MP0003705_abnormal_hypodermis_morpholog2.58353317
13MP0003111_abnormal_nucleus_morphology2.48166639
14MP0003693_abnormal_embryo_hatching2.46069020
15MP0005058_abnormal_lysosome_morphology2.44190518
16MP0005220_abnormal_exocrine_pancreas2.35625625
17MP0009840_abnormal_foam_cell2.33980480
18MP0003195_calcinosis2.26407305
19MP0002877_abnormal_melanocyte_morpholog2.22732473
20MP0004957_abnormal_blastocyst_morpholog2.20147030
21MP0003252_abnormal_bile_duct2.14048589
22MP0003191_abnormal_cellular_cholesterol2.07579887
23MP0002796_impaired_skin_barrier2.04897807
24MP0010329_abnormal_lipoprotein_level2.03635630
25MP0010094_abnormal_chromosome_stability1.99051743
26MP0008438_abnormal_cutaneous_collagen1.98024387
27MP0003303_peritoneal_inflammation1.96551400
28MP0003077_abnormal_cell_cycle1.93819189
29MP0001849_ear_inflammation1.93391318
30MP0003868_abnormal_feces_composition1.92351396
31MP0002909_abnormal_adrenal_gland1.86055288
32MP0008875_abnormal_xenobiotic_pharmacok1.84353187
33MP0006054_spinal_hemorrhage1.83521398
34MP0005501_abnormal_skin_physiology1.82918204
35MP0003453_abnormal_keratinocyte_physiol1.82710789
36MP0000537_abnormal_urethra_morphology1.76531358
37MP0009643_abnormal_urine_homeostasis1.72348300
38MP0002693_abnormal_pancreas_physiology1.71768840
39MP0000609_abnormal_liver_physiology1.71670839
40MP0010307_abnormal_tumor_latency1.68890123
41MP0003436_decreased_susceptibility_to1.68730631
42MP0008260_abnormal_autophagy1.67738111
43MP0001730_embryonic_growth_arrest1.66220501
44MP0005623_abnormal_meninges_morphology1.64920118
45MP0001348_abnormal_lacrimal_gland1.63536391
46MP0002396_abnormal_hematopoietic_system1.60750567
47MP0001944_abnormal_pancreas_morphology1.58933569
48MP0004858_abnormal_nervous_system1.57848615
49MP0002060_abnormal_skin_morphology1.56554047
50MP0005332_abnormal_amino_acid1.56510332
51MP0008932_abnormal_embryonic_tissue1.53405437
52MP0000350_abnormal_cell_proliferation1.53368641
53MP0004808_abnormal_hematopoietic_stem1.50848562
54MP0002138_abnormal_hepatobiliary_system1.44967529
55MP0001661_extended_life_span1.44572614
56MP0002118_abnormal_lipid_homeostasis1.42483986
57MP0000604_amyloidosis1.39410108
58MP0005319_abnormal_enzyme/_coenzyme1.39124730
59MP0005257_abnormal_intraocular_pressure1.38321906
60MP0002166_altered_tumor_susceptibility1.38112130
61MP0003091_abnormal_cell_migration1.36960768
62MP0003172_abnormal_lysosome_physiology1.35654147
63MP0001835_abnormal_antigen_presentation1.32340552
64MP0000678_abnormal_parathyroid_gland1.29806967
65MP0004264_abnormal_extraembryonic_tissu1.28789811
66MP0003566_abnormal_cell_adhesion1.28732552
67MP0008057_abnormal_DNA_replication1.28017556
68MP0000733_abnormal_muscle_development1.27500439
69MP0005464_abnormal_platelet_physiology1.26956743
70MP0004947_skin_inflammation1.26161793
71MP0002080_prenatal_lethality1.25728897
72MP0001765_abnormal_ion_homeostasis1.25686180
73MP0005636_abnormal_mineral_homeostasis1.25240245
74MP0010352_gastrointestinal_tract_polyps1.22119363
75MP0004782_abnormal_surfactant_physiolog1.20825675
76MP0000685_abnormal_immune_system1.20179711
77MP0008961_abnormal_basal_metabolism1.20092344
78MP0005409_darkened_coat_color1.19812762
79MP0000013_abnormal_adipose_tissue1.19782698
80MP0001845_abnormal_inflammatory_respons1.19664782
81MP0000579_abnormal_nail_morphology1.19376705
82MP0002086_abnormal_extraembryonic_tissu1.18920634
83MP0002078_abnormal_glucose_homeostasis1.17897236
84MP0001216_abnormal_epidermal_layer1.17175603
85MP0003984_embryonic_growth_retardation1.17111872
86MP0005380_embryogenesis_phenotype1.17108826
87MP0001672_abnormal_embryogenesis/_devel1.17108826
88MP0003806_abnormal_nucleotide_metabolis1.17007741
89MP0009333_abnormal_splenocyte_physiolog1.16828171
90MP0001756_abnormal_urination1.15963976
91MP0008007_abnormal_cellular_replicative1.15600407
92MP0005621_abnormal_cell_physiology1.15559797
93MP0002089_abnormal_postnatal_growth/wei1.15445320
94MP0004272_abnormal_basement_membrane1.14172216
95MP0008469_abnormal_protein_level1.13582882
96MP0005584_abnormal_enzyme/coenzyme_acti1.12785076
97MP0010155_abnormal_intestine_physiology1.12024909
98MP0009053_abnormal_anal_canal1.11168446
99MP0009780_abnormal_chondrocyte_physiolo1.09829003
100MP0002088_abnormal_embryonic_growth/wei1.09772965
101MP0004043_abnormal_pH_regulation1.07865569
102MP0010030_abnormal_orbit_morphology1.05800841
103MP0000598_abnormal_liver_morphology1.05444278
104MP0001533_abnormal_skeleton_physiology1.05063349
105MP0003866_abnormal_defecation1.04374630
106MP0001881_abnormal_mammary_gland1.03496821
107MP0004185_abnormal_adipocyte_glucose1.03306966
108MP0003183_abnormal_peptide_metabolism1.02025046
109MP0003763_abnormal_thymus_physiology1.01518907
110MP0002098_abnormal_vibrissa_morphology1.00996655
111MP0001873_stomach_inflammation1.00571778
112MP0005310_abnormal_salivary_gland0.99925003
113MP0005275_abnormal_skin_tensile0.99176579
114MP0001697_abnormal_embryo_size0.98866397
115MP0003656_abnormal_erythrocyte_physiolo0.98633984
116MP0003329_amyloid_beta_deposits0.97609020
117MP0001790_abnormal_immune_system0.96663800
118MP0005387_immune_system_phenotype0.96663800
119MP0003959_abnormal_lean_body0.96339348
120MP0005000_abnormal_immune_tolerance0.94041373
121MP0005025_abnormal_response_to0.94019262
122MP0000313_abnormal_cell_death0.93490414
123MP0000627_abnormal_mammary_gland0.92908510
124MP0000003_abnormal_adipose_tissue0.91428383
125MP0002419_abnormal_innate_immunity0.89289106
126MP0009672_abnormal_birth_weight0.88829232
127MP0002136_abnormal_kidney_physiology0.88712622
128MP0004130_abnormal_muscle_cell0.88349218
129MP0003786_premature_aging0.87454391
130MP0005384_cellular_phenotype0.87432472
131MP0003075_altered_response_to0.87399878
132MP0009642_abnormal_blood_homeostasis0.86658569
133MP0001800_abnormal_humoral_immune0.86208270
134MP0009931_abnormal_skin_appearance0.85544544
135MP0000762_abnormal_tongue_morphology0.84969631
136MP0005375_adipose_tissue_phenotype0.83426289
137MP0001915_intracranial_hemorrhage0.83313721
138MP0009785_altered_susceptibility_to0.81207178
139MP0008058_abnormal_DNA_repair0.81022445
140MP0002896_abnormal_bone_mineralization0.80615559
141MP0005666_abnormal_adipose_tissue0.80209294
142MP0002019_abnormal_tumor_incidence0.79081301
143MP0000858_altered_metastatic_potential0.78908087
144MP0002009_preneoplasia0.78202732
145MP0002254_reproductive_system_inflammat0.78135679
146MP0000566_synostosis0.78050778
147MP0000465_gastrointestinal_hemorrhage0.77854455
148MP0003186_abnormal_redox_activity0.77502507
149MP0002085_abnormal_embryonic_tissue0.77282811
150MP0005023_abnormal_wound_healing0.77167754
151MP0000467_abnormal_esophagus_morphology0.76743864
152MP0001958_emphysema0.76577335
153MP0000358_abnormal_cell_content/0.76480210
154MP0010771_integument_phenotype0.76319536
155MP0004019_abnormal_vitamin_homeostasis0.76099058
156MP0002723_abnormal_immune_serum0.75437133
157MP0002452_abnormal_antigen_presenting0.75219322
158MP0002084_abnormal_developmental_patter0.74625511
159MP0010678_abnormal_skin_adnexa0.74355374
160MP0001243_abnormal_dermal_layer0.74164054
161MP0003638_abnormal_response/metabolism_0.74154196
162MP0002970_abnormal_white_adipose0.73368183
163MP0000377_abnormal_hair_follicle0.72293248
164MP0005535_abnormal_body_temperature0.72081355
165MP0000490_abnormal_crypts_of0.71557124
166MP0003795_abnormal_bone_structure0.71526888
167MP0009763_increased_sensitivity_to0.69875773
168MP0002933_joint_inflammation0.69868948
169MP0002006_tumorigenesis0.69520240
170MP0005448_abnormal_energy_balance0.69257068
171MP0000477_abnormal_intestine_morphology0.69211795
172MP0005671_abnormal_response_to0.68964303
173MP0010630_abnormal_cardiac_muscle0.68132950
174MP0000747_muscle_weakness0.65440913
175MP0005197_abnormal_uvea_morphology0.63032707

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)3.98189001
2Abnormality of aromatic amino acid family metabolism (HP:0004338)3.60146291
3Deep venous thrombosis (HP:0002625)3.58792169
4Abnormality of the common coagulation pathway (HP:0010990)3.47583447
5Premature rupture of membranes (HP:0001788)3.37085585
6Dysostosis multiplex (HP:0000943)3.34642983
7Mucopolysacchariduria (HP:0008155)3.24892567
8Urinary glycosaminoglycan excretion (HP:0003541)3.24892567
9Vertebral compression fractures (HP:0002953)3.22018563
10Sparse lateral eyebrow (HP:0005338)3.21896759
11Vacuolated lymphocytes (HP:0001922)3.19927992
12Xanthomatosis (HP:0000991)3.17967002
13Hyperacusis (HP:0010780)3.10330335
14Hypoglycemic coma (HP:0001325)3.09402538
15Ankyloglossia (HP:0010296)3.08302514
16Ulnar bowing (HP:0003031)3.04058862
17Ketosis (HP:0001946)3.03134494
18Abnormality of the distal phalanges of the toes (HP:0010182)3.01661678
19Ketoacidosis (HP:0001993)2.89877849
20Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87549359
21Complement deficiency (HP:0004431)2.84247140
22Abnormality of polysaccharide metabolism (HP:0011012)2.83364799
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83364799
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83364799
25Trismus (HP:0000211)2.83261984
26Broad face (HP:0000283)2.83137637
27Abnormality of oral frenula (HP:0000190)2.75844597
28Short nail (HP:0001799)2.70975489
29Gout (HP:0001997)2.67930646
30Intrahepatic cholestasis (HP:0001406)2.64621228
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.62705926
32Osteolytic defects of the hand bones (HP:0009699)2.62705926
33Flat acetabular roof (HP:0003180)2.57174699
34Increased cerebral lipofuscin (HP:0011813)2.54583336
35Distal lower limb amyotrophy (HP:0008944)2.53970909
36Selective tooth agenesis (HP:0001592)2.53488111
37Asymmetry of the thorax (HP:0001555)2.51247178
38Late onset (HP:0003584)2.45233230
39Myocardial infarction (HP:0001658)2.45093187
40Prolonged partial thromboplastin time (HP:0003645)2.42250694
41Fat malabsorption (HP:0002630)2.37801251
42Long palpebral fissure (HP:0000637)2.37494947
43Elbow flexion contracture (HP:0002987)2.35660673
44Deviation of the thumb (HP:0009603)2.32372396
45Abnormality of the Achilles tendon (HP:0005109)2.30779168
46Hypoglycemic seizures (HP:0002173)2.30264468
47Ragged-red muscle fibers (HP:0003200)2.30186293
48Systemic lupus erythematosus (HP:0002725)2.29578598
49Hypobetalipoproteinemia (HP:0003563)2.28721179
50Abnormality of complement system (HP:0005339)2.26581573
51Dysmetric saccades (HP:0000641)2.25744224
52Abnormality of purine metabolism (HP:0004352)2.25289946
53Natal tooth (HP:0000695)2.25203868
54Beaking of vertebral bodies (HP:0004568)2.19104932
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.19074809
56Interstitial pulmonary disease (HP:0006530)2.15502636
57Joint hemorrhage (HP:0005261)2.15457369
58Fragile skin (HP:0001030)2.14758459
59Nasal polyposis (HP:0100582)2.14558907
60Cerebral aneurysm (HP:0004944)2.14436645
61Abnormality of the nasal mucosa (HP:0000433)2.14314234
62Achilles tendon contracture (HP:0001771)2.13758130
63Hyperlipoproteinemia (HP:0010980)2.13711686
64Long toe (HP:0010511)2.12899851
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12471253
66Increased connective tissue (HP:0009025)2.11614908
67Microvesicular hepatic steatosis (HP:0001414)2.10337283
68Proximal placement of thumb (HP:0009623)2.09285458
69Hyperinsulinemic hypoglycemia (HP:0000825)2.07979744
70Abnormal cartilage morphology (HP:0002763)2.06882282
71Progressive external ophthalmoplegia (HP:0000590)2.05139616
72Abdominal distention (HP:0003270)2.02707885
73Abnormal tarsal ossification (HP:0008369)2.02501294
74Hyperammonemia (HP:0001987)2.02037505
75Protrusio acetabuli (HP:0003179)2.01292637
76Protuberant abdomen (HP:0001538)2.00208351
77Thoracic kyphosis (HP:0002942)1.99923195
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99390099
79Hyperparathyroidism (HP:0000843)1.98861187
80Thin bony cortex (HP:0002753)1.98796703
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.98537925
82Menorrhagia (HP:0000132)1.97156533
83Distal lower limb muscle weakness (HP:0009053)1.96627698
84Advanced eruption of teeth (HP:0006288)1.95058916
85Spastic diplegia (HP:0001264)1.93732768
86Global brain atrophy (HP:0002283)1.93418627
87Disproportionate tall stature (HP:0001519)1.93165370
88Generalized aminoaciduria (HP:0002909)1.93105365
89Hand muscle atrophy (HP:0009130)1.92858538
90Aneurysm (HP:0002617)1.92518852
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.92054873
92Cervical subluxation (HP:0003308)1.91453271
93Blue sclerae (HP:0000592)1.90638084
94Skin nodule (HP:0200036)1.90112789
95Pancreatitis (HP:0001733)1.89893574
96Squamous cell carcinoma (HP:0002860)1.89801847
97Abnormality of the thoracic spine (HP:0100711)1.89623895
98Spinal cord lesions (HP:0100561)1.87889832
99Syringomyelia (HP:0003396)1.87889832
100Abnormality of transition element cation homeostasis (HP:0011030)1.87686198
101Abnormal foot bone ossification (HP:0010675)1.87198431
102Chronic otitis media (HP:0000389)1.86478218
103Abnormality of the lumbar spine (HP:0100712)1.86125293
104Glomerulonephritis (HP:0000099)1.85962538
105Abnormality of endocrine pancreas physiology (HP:0012093)1.85875801
106Abnormality of the pancreatic islet cells (HP:0006476)1.85875801
107Abnormal platelet function (HP:0011869)1.85008447
108Impaired platelet aggregation (HP:0003540)1.85008447
109Steatorrhea (HP:0002570)1.83914453
110Hypokinesia (HP:0002375)1.83741043
111Hyperglycinemia (HP:0002154)1.82949944
112Micronodular cirrhosis (HP:0001413)1.82877164
113Hypolipoproteinemia (HP:0010981)1.82426162
114Progressive muscle weakness (HP:0003323)1.81375939
115Aortic aneurysm (HP:0004942)1.80586948
116Spinal cord compression (HP:0002176)1.80358636
117Severe short stature (HP:0003510)1.80025809
118Wormian bones (HP:0002645)1.79716900
119Symptomatic seizures (HP:0011145)1.79056453
120Recurrent gram-negative bacterial infections (HP:0005420)1.78985518
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77755599
122Hyperglycemia (HP:0003074)1.76734390
123Abnormal ossification of hand bones (HP:0005921)1.76556124
124Multiple enchondromatosis (HP:0005701)1.76189514
125Atrophic scars (HP:0001075)1.75935926
126Rough bone trabeculation (HP:0100670)1.75737882
127Nuclear cataract (HP:0100018)1.74908095
128Hyperbilirubinemia (HP:0002904)1.74792369
129Retinal atrophy (HP:0001105)1.74709435
130Patellar dislocation (HP:0002999)1.73002145
131Conjunctival hamartoma (HP:0100780)1.72580879
132Death in childhood (HP:0003819)1.72494666
133Abnormality of the umbilical cord (HP:0010881)1.72157154
134Reduced subcutaneous adipose tissue (HP:0003758)1.71902199
135Hepatocellular carcinoma (HP:0001402)1.71617881
136Thoracolumbar scoliosis (HP:0002944)1.71471180
137Type II lissencephaly (HP:0007260)1.71363877
138Broad distal phalanx of finger (HP:0009836)1.71266430
139Upper limb amyotrophy (HP:0009129)1.70706802
140Distal upper limb amyotrophy (HP:0007149)1.70706802
141Joint stiffness (HP:0001387)1.70519366
142Bone pain (HP:0002653)1.70505044
143Pili torti (HP:0003777)1.70154526
144Back pain (HP:0003418)1.69327183
145Eczematoid dermatitis (HP:0000976)1.69321556
146Peritonitis (HP:0002586)1.69197343
147Colitis (HP:0002583)1.68979341
148Sensorimotor neuropathy (HP:0007141)1.68588962
149Malnutrition (HP:0004395)1.67939510
150Gastrointestinal inflammation (HP:0004386)1.67608680
151Thrombocytosis (HP:0001894)1.67490403
152Overlapping toe (HP:0001845)1.65084221
153Abnormality of carpal bone ossification (HP:0006257)1.64756985
154Insomnia (HP:0100785)1.64503098
155Entropion (HP:0000621)1.63581611
156Termporal pattern (HP:0011008)1.63258782
157Insidious onset (HP:0003587)1.63258782
158Flared metaphyses (HP:0003015)1.62941518
159Ankle contracture (HP:0006466)1.62666848
160Ridged nail (HP:0001807)1.62553932
161Dislocated radial head (HP:0003083)1.62479111
162Deep philtrum (HP:0002002)1.60460765
163Abnormality of the tricuspid valve (HP:0001702)1.58359291
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56004806
165Breast hypoplasia (HP:0003187)1.54957839
166Mitral regurgitation (HP:0001653)1.54753253
167Long eyelashes (HP:0000527)1.54182645
168Nonimmune hydrops fetalis (HP:0001790)1.52938677
169Neonatal death (HP:0003811)1.52768526
170Acanthosis nigricans (HP:0000956)1.51723887
171Nail dystrophy (HP:0008404)1.51596013
172Generalized amyotrophy (HP:0003700)1.51404519
173Subacute progressive viral hepatitis (HP:0006572)1.50561744
174Abnormality of pyrimidine metabolism (HP:0004353)1.50445388
175Mitral stenosis (HP:0001718)1.50256203
176Bowing of the arm (HP:0006488)1.50177003
177Bowed forearm bones (HP:0003956)1.50177003
178Centrally nucleated skeletal muscle fibers (HP:0003687)1.49313435
179Aplasia/Hypoplasia of the sacrum (HP:0008517)1.48472724
180Biconcave vertebral bodies (HP:0004586)1.47284048
181Abnormality of the calcaneus (HP:0008364)1.47213017
182Hemorrhage of the eye (HP:0011885)1.47161460
183Lower limb amyotrophy (HP:0007210)1.46244986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.15701225
2TRIB34.97913399
3PKN23.88414088
4SMG13.14190460
5ICK3.12844370
6BCKDK3.12041287
7SCYL22.99170113
8PRPF4B2.88925527
9CDK122.81126731
10TAOK32.66718704
11PASK2.41539757
12INSRR2.40443788
13PTK62.10161484
14FRK2.05595308
15EEF2K2.03798745
16SIK11.99497237
17MAP3K101.94866342
18NME21.83063613
19LRRK21.75117491
20FLT31.66225296
21MET1.64060464
22RIPK11.63563524
23MAP3K21.62242759
24FGFR41.59203750
25ZAP701.56639111
26MAP4K11.55255251
27TBK11.54731216
28ARAF1.45514170
29PDGFRA1.45308826
30PBK1.44594624
31RPS6KB21.39748539
32MAP3K31.39027984
33IRAK31.37939997
34TYK21.34124052
35CAMKK11.33527135
36BUB11.28765418
37LATS21.26230185
38JAK31.26049400
39PDK21.24007607
40MAP3K131.17432488
41KSR21.16735058
42MAP2K21.16058818
43MAP2K31.15602675
44EIF2AK11.13486722
45MAP3K11.12897818
46TAOK21.11876843
47EIF2AK31.10574957
48RET1.05646228
49TESK11.05279155
50EPHB11.04320251
51CDK71.02953807
52JAK21.02860000
53TTN1.02334531
54GRK61.01880787
55TTK1.00802405
56JAK11.00683564
57RAF11.00353305
58TGFBR20.99396275
59PAK40.99222475
60TESK20.98566703
61CDC70.98102073
62MST1R0.96021459
63BTK0.92381692
64CDK40.89392783
65PRKD30.88298859
66BRAF0.88037684
67IRAK20.86565167
68TAOK10.86173442
69PTK20.83300680
70CDK80.82509979
71MAPKAPK30.78834314
72NEK90.76915921
73PAK20.76359336
74DYRK1B0.75073413
75BRSK10.74221500
76CHEK20.73330866
77AURKA0.70701264
78HIPK20.70625816
79PIK3CG0.69084048
80MAP3K110.68715544
81MAP3K90.66495561
82IKBKE0.66110711
83KDR0.66061848
84PRKCH0.65947132
85PDGFRB0.65885829
86AURKB0.64028336
87NEK10.63688271
88ABL20.63518460
89CHEK10.61704068
90CSK0.60834540
91MAP2K10.60500633
92IRAK40.58337459
93RIPK40.57355064
94MELK0.57133198
95TSSK60.56964783
96SRPK10.56760207
97SYK0.54304812
98NTRK10.54294407
99MAP3K140.54037953
100WNK40.53079088
101PDK10.52839833
102STK40.52282168
103RPS6KA40.51271548
104KIT0.51259652
105CDK90.51076142
106ITK0.49701697
107ILK0.49649535
108PDPK10.49182167
109PIM20.49063409
110FGFR30.47885087
111CAMKK20.45161865
112MAPK110.44961577
113MAP3K80.44632124
114TGFBR10.44513638
115MAP3K70.44279355
116HCK0.43736461
117STK240.43454468
118ALK0.41947497
119STK100.41312023
120CSF1R0.40954823
121RPS6KL10.40829303
122RPS6KC10.40829303
123PRKCI0.40643437
124WEE10.40077144
125AKT20.40071922
126BLK0.40038474
127PRKD20.39834251
128EPHA30.39160516
129MARK20.39069908
130EGFR0.38927575
131RPS6KA20.38759144
132CDC42BPA0.36789505
133MTOR0.36636795
134NEK20.36605443
135PRKG20.35175159
136NEK60.34971663
137ATR0.34618776
138BMX0.34453103
139NME10.33216953
140LCK0.32918741
141LMTK20.32812171
142GSK3A0.32759027
143CAMK1D0.32674524
144FES0.32567205
145CDK60.31644367
146PAK10.31591310
147LATS10.31360498
148RPS6KA10.31243481
149CDK20.29252787
150IRAK10.29065230
151LYN0.28777198
152TEC0.28383625
153SIK20.27566475
154DDR20.27488677
155FER0.27397520
156EPHA20.26390852

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.32896153
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.15547233
3DNA replication_Homo sapiens_hsa030303.04422432
4Protein export_Homo sapiens_hsa030602.80625352
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.44050373
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37922208
7Nitrogen metabolism_Homo sapiens_hsa009102.23389068
8N-Glycan biosynthesis_Homo sapiens_hsa005102.20967880
9Fat digestion and absorption_Homo sapiens_hsa049752.06303616
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99124848
11Sulfur metabolism_Homo sapiens_hsa009201.95675298
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90544375
13Selenocompound metabolism_Homo sapiens_hsa004501.89559890
14Cell cycle_Homo sapiens_hsa041101.85114933
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78965740
16Vitamin B6 metabolism_Homo sapiens_hsa007501.78380503
17Complement and coagulation cascades_Homo sapiens_hsa046101.78113440
18Tryptophan metabolism_Homo sapiens_hsa003801.77752561
19Small cell lung cancer_Homo sapiens_hsa052221.75204315
20Fatty acid degradation_Homo sapiens_hsa000711.71539598
21Fructose and mannose metabolism_Homo sapiens_hsa000511.70689783
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.69586834
23Caffeine metabolism_Homo sapiens_hsa002321.67941880
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62250815
25Sulfur relay system_Homo sapiens_hsa041221.60147766
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59879100
27Lysosome_Homo sapiens_hsa041421.58907439
28Folate biosynthesis_Homo sapiens_hsa007901.57075273
29Arginine biosynthesis_Homo sapiens_hsa002201.53942426
30Staphylococcus aureus infection_Homo sapiens_hsa051501.47966263
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44301841
32Base excision repair_Homo sapiens_hsa034101.42463930
33Mismatch repair_Homo sapiens_hsa034301.39513921
34Pancreatic secretion_Homo sapiens_hsa049721.36195446
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35310603
36Propanoate metabolism_Homo sapiens_hsa006401.32668720
37Starch and sucrose metabolism_Homo sapiens_hsa005001.31664869
38PPAR signaling pathway_Homo sapiens_hsa033201.28919759
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28447869
40Endometrial cancer_Homo sapiens_hsa052131.25650689
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24399789
42Viral carcinogenesis_Homo sapiens_hsa052031.23345647
43Other glycan degradation_Homo sapiens_hsa005111.22899592
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21319157
45Protein digestion and absorption_Homo sapiens_hsa049741.17354182
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16170530
47Fatty acid metabolism_Homo sapiens_hsa012121.15744515
48Renal cell carcinoma_Homo sapiens_hsa052111.15205232
49RNA transport_Homo sapiens_hsa030131.14147610
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13542066
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12983261
52MicroRNAs in cancer_Homo sapiens_hsa052061.11518640
53Antigen processing and presentation_Homo sapiens_hsa046121.10864095
54Bile secretion_Homo sapiens_hsa049761.10824982
55Nucleotide excision repair_Homo sapiens_hsa034201.09898558
56Pyrimidine metabolism_Homo sapiens_hsa002401.09763829
57Spliceosome_Homo sapiens_hsa030401.06405566
58mRNA surveillance pathway_Homo sapiens_hsa030151.05323172
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04775615
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.04620288
61Insulin resistance_Homo sapiens_hsa049311.02855126
62Lysine degradation_Homo sapiens_hsa003101.00645966
63Prostate cancer_Homo sapiens_hsa052151.00519770
64Apoptosis_Homo sapiens_hsa042100.99946009
65Glioma_Homo sapiens_hsa052140.97994244
66Proteoglycans in cancer_Homo sapiens_hsa052050.97344709
67Histidine metabolism_Homo sapiens_hsa003400.94227667
68Glycerolipid metabolism_Homo sapiens_hsa005610.94147565
69Renin-angiotensin system_Homo sapiens_hsa046140.93412941
70Hepatitis B_Homo sapiens_hsa051610.92605652
71Focal adhesion_Homo sapiens_hsa045100.90269182
72beta-Alanine metabolism_Homo sapiens_hsa004100.90232602
73Carbon metabolism_Homo sapiens_hsa012000.89458188
74Notch signaling pathway_Homo sapiens_hsa043300.89415843
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.88938411
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88003307
77Pentose phosphate pathway_Homo sapiens_hsa000300.87790562
78HTLV-I infection_Homo sapiens_hsa051660.87586843
79Peroxisome_Homo sapiens_hsa041460.87172497
80Insulin signaling pathway_Homo sapiens_hsa049100.86198265
81Pyruvate metabolism_Homo sapiens_hsa006200.85815343
82ErbB signaling pathway_Homo sapiens_hsa040120.85610852
83Butanoate metabolism_Homo sapiens_hsa006500.85359256
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.85164744
85ABC transporters_Homo sapiens_hsa020100.83744835
86Biosynthesis of amino acids_Homo sapiens_hsa012300.82700877
87Galactose metabolism_Homo sapiens_hsa000520.82163473
88Thyroid hormone synthesis_Homo sapiens_hsa049180.79684258
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78605529
90Adherens junction_Homo sapiens_hsa045200.78340310
91Prion diseases_Homo sapiens_hsa050200.77341652
92Systemic lupus erythematosus_Homo sapiens_hsa053220.77131121
93Legionellosis_Homo sapiens_hsa051340.76754473
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76261873
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75559640
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.74888897
97Hepatitis C_Homo sapiens_hsa051600.74875569
98ECM-receptor interaction_Homo sapiens_hsa045120.74013462
99One carbon pool by folate_Homo sapiens_hsa006700.73343433
100p53 signaling pathway_Homo sapiens_hsa041150.71801446
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71697348
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71322198
103Non-homologous end-joining_Homo sapiens_hsa034500.70351891
104Phenylalanine metabolism_Homo sapiens_hsa003600.70145237
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68830246
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.67229612
107Chronic myeloid leukemia_Homo sapiens_hsa052200.66582670
108Shigellosis_Homo sapiens_hsa051310.66550590
109B cell receptor signaling pathway_Homo sapiens_hsa046620.66305739
110Colorectal cancer_Homo sapiens_hsa052100.65678897
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65268302
112Vibrio cholerae infection_Homo sapiens_hsa051100.62579016
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62030325
114HIF-1 signaling pathway_Homo sapiens_hsa040660.60906360
115Ribosome_Homo sapiens_hsa030100.60678867
116Leishmaniasis_Homo sapiens_hsa051400.58481360
117Osteoclast differentiation_Homo sapiens_hsa043800.57488242
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56670286
119Epstein-Barr virus infection_Homo sapiens_hsa051690.56405630
120Chemical carcinogenesis_Homo sapiens_hsa052040.56379882
121Inositol phosphate metabolism_Homo sapiens_hsa005620.55179174
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54940129
123Bladder cancer_Homo sapiens_hsa052190.54701518
124Arginine and proline metabolism_Homo sapiens_hsa003300.53891701
125Vitamin digestion and absorption_Homo sapiens_hsa049770.53234921
126Alcoholism_Homo sapiens_hsa050340.52006462
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51989203
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51675700
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50683388
130Toxoplasmosis_Homo sapiens_hsa051450.50631451
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50190342
132Amoebiasis_Homo sapiens_hsa051460.50059389
133VEGF signaling pathway_Homo sapiens_hsa043700.49416392
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47233090
135Influenza A_Homo sapiens_hsa051640.46508760
136Hippo signaling pathway_Homo sapiens_hsa043900.45285927
137Prolactin signaling pathway_Homo sapiens_hsa049170.44942992
138Pancreatic cancer_Homo sapiens_hsa052120.44568982
139Pertussis_Homo sapiens_hsa051330.44547742
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44295673
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44252376
142Pathways in cancer_Homo sapiens_hsa052000.43980896
143Melanoma_Homo sapiens_hsa052180.43560184
144Non-small cell lung cancer_Homo sapiens_hsa052230.42522298
145Glucagon signaling pathway_Homo sapiens_hsa049220.41326230
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41108655
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40075126
148AMPK signaling pathway_Homo sapiens_hsa041520.40032787
149mTOR signaling pathway_Homo sapiens_hsa041500.39562727
150Tuberculosis_Homo sapiens_hsa051520.39011543
151Acute myeloid leukemia_Homo sapiens_hsa052210.38028067
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36617742
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36499711
154Glutathione metabolism_Homo sapiens_hsa004800.36351949
155Tyrosine metabolism_Homo sapiens_hsa003500.35479515
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.35294752
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34853142
158Thyroid cancer_Homo sapiens_hsa052160.34722298
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.34302439

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »