CLPX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.65034589
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.65034589
3L-phenylalanine metabolic process (GO:0006558)6.45804895
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.45804895
5aromatic amino acid family catabolic process (GO:0009074)6.09348304
6serine family amino acid catabolic process (GO:0009071)5.86440316
7cysteine metabolic process (GO:0006534)5.74273990
8tryptophan catabolic process (GO:0006569)5.59891496
9indole-containing compound catabolic process (GO:0042436)5.59891496
10indolalkylamine catabolic process (GO:0046218)5.59891496
11glyoxylate metabolic process (GO:0046487)5.58915939
12kynurenine metabolic process (GO:0070189)5.48952298
13piRNA metabolic process (GO:0034587)5.38580210
14tryptophan metabolic process (GO:0006568)5.33184991
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.30567229
16glycine metabolic process (GO:0006544)5.25141268
17bile acid biosynthetic process (GO:0006699)5.24599411
18sulfur amino acid catabolic process (GO:0000098)5.18320016
19mitotic sister chromatid cohesion (GO:0007064)5.13942363
20amino-acid betaine metabolic process (GO:0006577)5.02991912
21lysine metabolic process (GO:0006553)5.00636055
22lysine catabolic process (GO:0006554)5.00636055
23homocysteine metabolic process (GO:0050667)4.96859962
24alpha-linolenic acid metabolic process (GO:0036109)4.96626149
25urea metabolic process (GO:0019627)4.95034255
26urea cycle (GO:0000050)4.95034255
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86060363
28serine family amino acid metabolic process (GO:0009069)4.82036872
29regulation of protein activation cascade (GO:2000257)4.80239300
30CENP-A containing nucleosome assembly (GO:0034080)4.76876882
31regulation of centriole replication (GO:0046599)4.76776274
32mitotic metaphase plate congression (GO:0007080)4.73977133
33aromatic amino acid family metabolic process (GO:0009072)4.71285615
34negative regulation of fibrinolysis (GO:0051918)4.69119823
35complement activation, alternative pathway (GO:0006957)4.67825796
36chromatin remodeling at centromere (GO:0031055)4.62500159
37nitrogen cycle metabolic process (GO:0071941)4.57134668
38serine family amino acid biosynthetic process (GO:0009070)4.56503435
39peptidyl-glutamic acid carboxylation (GO:0017187)4.54262010
40protein carboxylation (GO:0018214)4.54262010
41bile acid metabolic process (GO:0008206)4.52248271
42alpha-amino acid catabolic process (GO:1901606)4.52223891
43synapsis (GO:0007129)4.50413070
44regulation of complement activation (GO:0030449)4.49982376
45regulation of fibrinolysis (GO:0051917)4.47682765
46high-density lipoprotein particle remodeling (GO:0034375)4.44937443
47regulation of triglyceride catabolic process (GO:0010896)4.34274476
48male meiosis I (GO:0007141)4.30781067
49DNA methylation involved in gamete generation (GO:0043046)4.28192251
50nuclear pore organization (GO:0006999)4.25608508
51nuclear pore complex assembly (GO:0051292)4.25374051
52regulation of meiosis I (GO:0060631)4.25057573
53cellular amino acid catabolic process (GO:0009063)4.22888922
54cellular ketone body metabolic process (GO:0046950)4.19380247
55tyrosine metabolic process (GO:0006570)4.18003664
56metaphase plate congression (GO:0051310)4.16788944
57acylglycerol homeostasis (GO:0055090)4.15411086
58triglyceride homeostasis (GO:0070328)4.15411086
59sister chromatid cohesion (GO:0007062)4.15136789
60histone exchange (GO:0043486)4.12360598
61urate metabolic process (GO:0046415)4.08870157
62indolalkylamine metabolic process (GO:0006586)3.95941532
632-oxoglutarate metabolic process (GO:0006103)3.94442419
64biotin metabolic process (GO:0006768)3.94186620
65bile acid and bile salt transport (GO:0015721)3.92060886
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.91705278
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.91705278
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.91705278
69regulation of histone H3-K9 methylation (GO:0051570)3.90548541
70macromolecular complex remodeling (GO:0034367)3.89472123
71plasma lipoprotein particle remodeling (GO:0034369)3.89472123
72protein-lipid complex remodeling (GO:0034368)3.89472123
73reverse cholesterol transport (GO:0043691)3.89241647
74regulation of cholesterol esterification (GO:0010872)3.88479121
75fatty acid beta-oxidation (GO:0006635)3.88327350
76acetyl-CoA metabolic process (GO:0006084)3.85000977
77amine catabolic process (GO:0009310)3.83994072
78cellular biogenic amine catabolic process (GO:0042402)3.83994072
79organic acid catabolic process (GO:0016054)3.83493615
80carboxylic acid catabolic process (GO:0046395)3.83493615
81pantothenate metabolic process (GO:0015939)3.80819215
82coenzyme catabolic process (GO:0009109)3.79002985
83fatty acid oxidation (GO:0019395)3.77478854
84aspartate family amino acid catabolic process (GO:0009068)3.76676678
85valine metabolic process (GO:0006573)3.75323263
86ethanol oxidation (GO:0006069)3.74862676
87plasma lipoprotein particle clearance (GO:0034381)3.72856087
88fatty acid catabolic process (GO:0009062)3.71749871
89short-chain fatty acid metabolic process (GO:0046459)3.69693745
90lipid oxidation (GO:0034440)3.69521184
91carnitine metabolic process (GO:0009437)3.68649101
92DNA replication checkpoint (GO:0000076)3.68593184
93imidazole-containing compound metabolic process (GO:0052803)3.67968533
94mitotic chromosome condensation (GO:0007076)3.66400948
95branched-chain amino acid catabolic process (GO:0009083)3.66236234
96glutamate metabolic process (GO:0006536)3.65598394
97gene silencing by RNA (GO:0031047)3.64423381
98benzene-containing compound metabolic process (GO:0042537)3.62785847
99folic acid metabolic process (GO:0046655)3.62218251
100monocarboxylic acid catabolic process (GO:0072329)3.62145109
101negative regulation of cholesterol transport (GO:0032375)3.60704815
102negative regulation of sterol transport (GO:0032372)3.60704815
103ketone body metabolic process (GO:1902224)3.60396673
104cellular modified amino acid catabolic process (GO:0042219)3.58556988
105S-adenosylmethionine metabolic process (GO:0046500)3.55576278
106negative regulation of fatty acid biosynthetic process (GO:0045717)3.52777051
107regulation of sister chromatid cohesion (GO:0007063)3.52185380
108positive regulation of histone H3-K4 methylation (GO:0051571)3.51664338
109phospholipid efflux (GO:0033700)3.50978822
110regulation of bile acid biosynthetic process (GO:0070857)3.46852857
111cellular glucuronidation (GO:0052695)3.46610389
112drug transmembrane transport (GO:0006855)3.46540188
113regulation of cholesterol homeostasis (GO:2000188)3.45165166
114arginine metabolic process (GO:0006525)3.41098166
115heme transport (GO:0015886)3.41028070
116sulfur amino acid metabolic process (GO:0000096)3.40791781
117branched-chain amino acid metabolic process (GO:0009081)3.40356251
118L-serine metabolic process (GO:0006563)3.39373420
119positive regulation of triglyceride lipase activity (GO:0061365)3.38870729
120positive regulation of lipoprotein lipase activity (GO:0051006)3.38870729
121drug catabolic process (GO:0042737)3.38774179
122DNA replication-independent nucleosome assembly (GO:0006336)3.38461591
123DNA replication-independent nucleosome organization (GO:0034724)3.38461591
124positive regulation of chromosome segregation (GO:0051984)3.37545846
125dicarboxylic acid biosynthetic process (GO:0043650)3.37413534
126establishment of chromosome localization (GO:0051303)3.37171914
127meiotic cell cycle (GO:0051321)3.33543704
128male meiosis (GO:0007140)3.33418917
129phospholipid homeostasis (GO:0055091)3.33072910
130blood coagulation, intrinsic pathway (GO:0007597)3.32667807
131regulation of nuclear cell cycle DNA replication (GO:0033262)3.31967490
132reciprocal DNA recombination (GO:0035825)3.19869662
133reciprocal meiotic recombination (GO:0007131)3.19869662
134regulation of centrosome cycle (GO:0046605)3.16564045
135attachment of spindle microtubules to kinetochore (GO:0008608)3.15711492
136regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.14461497
137meiosis I (GO:0007127)3.13982326
138negative regulation of DNA-dependent DNA replication (GO:2000104)3.06628063
139pore complex assembly (GO:0046931)3.05036460
140meiotic nuclear division (GO:0007126)3.04858760
141oxidative demethylation (GO:0070989)3.04457615
142regulation of DNA endoreduplication (GO:0032875)3.02823745
143chromosome organization involved in meiosis (GO:0070192)3.01789295
144centriole replication (GO:0007099)2.95443967
145protein K6-linked ubiquitination (GO:0085020)2.92916944
146regulation of centrosome duplication (GO:0010824)2.90663273
147protein K11-linked deubiquitination (GO:0035871)2.89769678
148meiotic chromosome segregation (GO:0045132)2.86713971
149regulation of acyl-CoA biosynthetic process (GO:0050812)2.85435857
150maturation of 5.8S rRNA (GO:0000460)2.76990805
151mitotic nuclear envelope disassembly (GO:0007077)2.74161831
152negative regulation of DNA recombination (GO:0045910)2.73513659
153negative regulation of execution phase of apoptosis (GO:1900118)2.72455407
154meiotic cell cycle process (GO:1903046)2.71514832
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66958037
156interkinetic nuclear migration (GO:0022027)2.66591414
157response to pheromone (GO:0019236)2.63712502
158regulation of cofactor metabolic process (GO:0051193)2.63654821
159regulation of coenzyme metabolic process (GO:0051196)2.63654821
160peptidyl-threonine dephosphorylation (GO:0035970)2.63579055
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63111341
162formation of translation preinitiation complex (GO:0001731)2.63084723
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63068137
164negative regulation of translation, ncRNA-mediated (GO:0040033)2.63068137
165regulation of translation, ncRNA-mediated (GO:0045974)2.63068137
166single strand break repair (GO:0000012)2.61661589
167ribosome assembly (GO:0042255)2.60947081
168succinate metabolic process (GO:0006105)2.60817843
169organelle disassembly (GO:1903008)2.59464609
170amino acid salvage (GO:0043102)2.59163372
171L-methionine salvage (GO:0071267)2.59163372
172L-methionine biosynthetic process (GO:0071265)2.59163372
173ncRNA catabolic process (GO:0034661)2.57520971
174ribonucleoprotein complex disassembly (GO:0032988)2.57100267
175protein localization to chromosome, centromeric region (GO:0071459)2.56615066
176regulation of RNA export from nucleus (GO:0046831)2.56382955
177negative regulation of histone methylation (GO:0031061)2.55487396
178protein localization to chromosome (GO:0034502)2.54926863
179nuclear envelope disassembly (GO:0051081)2.54813751
180membrane disassembly (GO:0030397)2.54813751
181chromosome condensation (GO:0030261)2.54544949
182regulation of chromosome segregation (GO:0051983)2.53762782
183regulation of DNA methylation (GO:0044030)2.53285487
184sister chromatid segregation (GO:0000819)2.52722630
185DNA integration (GO:0015074)2.52166193
186somatic hypermutation of immunoglobulin genes (GO:0016446)2.51649912
187somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51649912
188histone H3-K36 demethylation (GO:0070544)2.50842964
189microtubule depolymerization (GO:0007019)2.49814779
190protein localization to kinetochore (GO:0034501)2.49224201
191monoubiquitinated protein deubiquitination (GO:0035520)2.47105039
192resolution of meiotic recombination intermediates (GO:0000712)2.47035348
193rRNA catabolic process (GO:0016075)2.46914596
194mitotic G2/M transition checkpoint (GO:0044818)2.45989462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.05573419
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.24806760
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.77506424
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.34899024
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18128273
6E2F7_22180533_ChIP-Seq_HELA_Human4.98131123
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.75799307
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.28562016
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81717896
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.12719523
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11733290
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09227974
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.08492097
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91474574
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78360268
16ZNF274_21170338_ChIP-Seq_K562_Hela2.74415034
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.72953935
18VDR_22108803_ChIP-Seq_LS180_Human2.48178416
19IGF1R_20145208_ChIP-Seq_DFB_Human2.47978020
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.42894469
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41864398
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33177162
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25854240
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.19519578
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15950936
26FUS_26573619_Chip-Seq_HEK293_Human2.12886249
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03965789
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0465473
29EWS_26573619_Chip-Seq_HEK293_Human1.93037206
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.90844648
31TAF15_26573619_Chip-Seq_HEK293_Human1.84984944
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81643934
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81162919
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77959059
35GATA1_22025678_ChIP-Seq_K562_Human1.77483718
36ELK1_19687146_ChIP-ChIP_HELA_Human1.77014977
37ZNF263_19887448_ChIP-Seq_K562_Human1.70788170
38* CLOCK_20551151_ChIP-Seq_293T_Human1.67873428
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65202202
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.65200814
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60772831
42* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59346611
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57495761
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54853250
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.54149410
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53378219
47ER_23166858_ChIP-Seq_MCF-7_Human1.53255172
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52216741
49AR_21909140_ChIP-Seq_LNCAP_Human1.52081406
50IRF1_19129219_ChIP-ChIP_H3396_Human1.48558955
51MYC_18940864_ChIP-ChIP_HL60_Human1.47567752
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44788353
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40989073
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38602979
55* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36717347
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32335307
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30480781
58P300_19829295_ChIP-Seq_ESCs_Human1.28045774
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27936606
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27817077
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27408595
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.25614557
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24086420
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.23750079
65* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23397537
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22712473
67HTT_18923047_ChIP-ChIP_STHdh_Human1.22539605
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20363882
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17422724
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16883558
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16741620
72* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16283462
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15611824
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14834597
75STAT3_23295773_ChIP-Seq_U87_Human1.14399889
76CBP_20019798_ChIP-Seq_JUKART_Human1.13369856
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13369856
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12750496
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11998012
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11545893
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11398728
82* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08772481
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.08047007
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07914100
85* ETS1_20019798_ChIP-Seq_JURKAT_Human1.07730725
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07325361
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06815314
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06205243
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06051000
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05469009
91TP53_22573176_ChIP-Seq_HFKS_Human1.05048063
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04950257
93TCF4_23295773_ChIP-Seq_U87_Human1.03973426
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03427266
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02757176
96NANOG_19829295_ChIP-Seq_ESCs_Human0.99638114
97SOX2_19829295_ChIP-Seq_ESCs_Human0.99638114
98* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99001546
99EZH2_22144423_ChIP-Seq_EOC_Human0.98844030
100SMAD4_21799915_ChIP-Seq_A2780_Human0.98456938
101TTF2_22483619_ChIP-Seq_HELA_Human0.98397385
102MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98035871
103SRF_21415370_ChIP-Seq_HL-1_Mouse0.97389646
104GBX2_23144817_ChIP-Seq_PC3_Human0.96589052
105CRX_20693478_ChIP-Seq_RETINA_Mouse0.96464524
106GATA4_25053715_ChIP-Seq_YYC3_Human0.96157794
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95835894
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95786323
109CDX2_22108803_ChIP-Seq_LS180_Human0.95297323
110AR_25329375_ChIP-Seq_VCAP_Human0.94578575
111SALL4_22934838_ChIP-ChIP_CD34+_Human0.93789169
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.93654926
113MYC_18555785_ChIP-Seq_MESCs_Mouse0.91543831
114ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91473831
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.91144237
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90308961
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90106938
118E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87964265
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86912519
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86012396
121RARB_24833708_ChIP-Seq_LIVER_Mouse0.85953005
122* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84503832
123GABP_19822575_ChIP-Seq_HepG2_Human0.84264901
124EST1_17652178_ChIP-ChIP_JURKAT_Human0.82028351
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78100947
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76661597
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74251819
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72461125
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.71778723
130MYCN_18555785_ChIP-Seq_MESCs_Mouse0.71776027
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69925681
132DCP1A_22483619_ChIP-Seq_HELA_Human0.69318633
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69268200
134MYC_19030024_ChIP-ChIP_MESCs_Mouse0.68812531
135* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.66770985
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.65746108
137* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.64911836
138* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64222442
139VDR_23849224_ChIP-Seq_CD4+_Human0.63256843
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62841899
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.62765054
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62420518
143FOXP3_21729870_ChIP-Seq_TREG_Human0.62323998
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.62078490
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62060556
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.61758528
147* KDM5A_27292631_Chip-Seq_BREAST_Human0.60927614
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.59457809
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.58985647
150ERG_20517297_ChIP-Seq_VCAP_Human0.58564497
151CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58467743
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.58351860
153CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.58258115
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.58196778
155P53_21459846_ChIP-Seq_SAOS-2_Human0.57803787
156CEBPB_22108803_ChIP-Seq_LS180_Human0.57425809
157* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55879550
158AR_20517297_ChIP-Seq_VCAP_Human0.55033688
159AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.54551238
160ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.54391999
161STAT1_17558387_ChIP-Seq_HELA_Human0.54198538
162POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.53937797
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.53861449
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.53706885
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53645676
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.52015663
167BCOR_27268052_Chip-Seq_Bcells_Human0.50920115
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.50819531
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50626187
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50219442
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.49091710
172GATA6_25053715_ChIP-Seq_YYC3_Human0.48509477
173FOXA1_25552417_ChIP-Seq_VCAP_Human0.48376451
174ESET_19884257_ChIP-Seq_ESCs_Mouse0.48216346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.45797119
2MP0005360_urolithiasis6.71613269
3MP0005365_abnormal_bile_salt6.03156644
4MP0005085_abnormal_gallbladder_physiolo5.85940247
5MP0003806_abnormal_nucleotide_metabolis4.46196252
6MP0008877_abnormal_DNA_methylation4.34512678
7MP0008875_abnormal_xenobiotic_pharmacok4.17504988
8MP0009840_abnormal_foam_cell3.54571676
9MP0003252_abnormal_bile_duct3.45904352
10MP0008057_abnormal_DNA_replication3.40801932
11MP0010329_abnormal_lipoprotein_level3.34552237
12MP0005332_abnormal_amino_acid3.07984585
13MP0008058_abnormal_DNA_repair2.99380190
14MP0010094_abnormal_chromosome_stability2.80010029
15MP0003195_calcinosis2.78093021
16MP0005083_abnormal_biliary_tract2.70035563
17MP0002009_preneoplasia2.61046019
18MP0003890_abnormal_embryonic-extraembry2.60133701
19MP0001666_abnormal_nutrient_absorption2.56963050
20MP0004957_abnormal_blastocyst_morpholog2.50260739
21MP0004019_abnormal_vitamin_homeostasis2.39545903
22MP0002638_abnormal_pupillary_reflex2.25904105
23MP0000609_abnormal_liver_physiology2.21553305
24MP0003111_abnormal_nucleus_morphology2.20042551
25MP0004145_abnormal_muscle_electrophysio2.15404277
26MP0003191_abnormal_cellular_cholesterol2.13390951
27MP0003077_abnormal_cell_cycle2.11594964
28MP0002118_abnormal_lipid_homeostasis2.08756902
29MP0005319_abnormal_enzyme/_coenzyme1.98429094
30MP0002138_abnormal_hepatobiliary_system1.94494914
31MP0001764_abnormal_homeostasis1.92554867
32MP0006292_abnormal_olfactory_placode1.89074418
33MP0001929_abnormal_gametogenesis1.88323164
34MP0005451_abnormal_body_composition1.81822270
35MP0002210_abnormal_sex_determination1.73922325
36MP0000569_abnormal_digit_pigmentation1.72291300
37MP0003868_abnormal_feces_composition1.66200705
38MP0001986_abnormal_taste_sensitivity1.55722744
39MP0009643_abnormal_urine_homeostasis1.55369252
40MP0002234_abnormal_pharynx_morphology1.54141860
41MP0005075_abnormal_melanosome_morpholog1.53949036
42MP0001188_hyperpigmentation1.52642083
43MP0000372_irregular_coat_pigmentation1.52600818
44MP0004215_abnormal_myocardial_fiber1.49542969
45MP0003186_abnormal_redox_activity1.46948784
46MP0006036_abnormal_mitochondrial_physio1.44129240
47MP0001661_extended_life_span1.44075767
48MP0009697_abnormal_copulation1.43958605
49MP0005584_abnormal_enzyme/coenzyme_acti1.42144694
50MP0003567_abnormal_fetal_cardiomyocyte1.40066980
51MP0003698_abnormal_male_reproductive1.38942545
52MP0003950_abnormal_plasma_membrane1.36560347
53MP0001145_abnormal_male_reproductive1.36438663
54MP0003656_abnormal_erythrocyte_physiolo1.33971773
55MP0003718_maternal_effect1.33838228
56MP0005187_abnormal_penis_morphology1.30452390
57MP0000653_abnormal_sex_gland1.28814421
58MP0005670_abnormal_white_adipose1.26582936
59MP0000598_abnormal_liver_morphology1.22466819
60MP0010234_abnormal_vibrissa_follicle1.21351151
61MP0005636_abnormal_mineral_homeostasis1.21199070
62MP0005380_embryogenesis_phenotype1.14521245
63MP0001672_abnormal_embryogenesis/_devel1.14521245
64MP0006072_abnormal_retinal_apoptosis1.13790542
65MP0001730_embryonic_growth_arrest1.13029100
66MP0008995_early_reproductive_senescence1.12962320
67MP0005253_abnormal_eye_physiology1.08042765
68MP0003011_delayed_dark_adaptation1.05697037
69MP0001756_abnormal_urination1.05158763
70MP0002837_dystrophic_cardiac_calcinosis1.04197227
71MP0003705_abnormal_hypodermis_morpholog1.03053550
72MP0005220_abnormal_exocrine_pancreas1.02490031
73MP0004130_abnormal_muscle_cell1.02487045
74MP0002160_abnormal_reproductive_system1.02235324
75MP0006035_abnormal_mitochondrial_morpho0.97866393
76MP0005647_abnormal_sex_gland0.97707866
77MP0002971_abnormal_brown_adipose0.95847150
78MP0002106_abnormal_muscle_physiology0.94933888
79MP0008932_abnormal_embryonic_tissue0.94716541
80MP0008260_abnormal_autophagy0.94245408
81MP0003941_abnormal_skin_development0.94150956
82MP0003984_embryonic_growth_retardation0.93904656
83MP0002088_abnormal_embryonic_growth/wei0.93099075
84MP0010307_abnormal_tumor_latency0.91448273
85MP0002078_abnormal_glucose_homeostasis0.91046168
86MP0005666_abnormal_adipose_tissue0.89958378
87MP0001697_abnormal_embryo_size0.89911947
88MP0002095_abnormal_skin_pigmentation0.89834165
89MP0003937_abnormal_limbs/digits/tail_de0.89797330
90MP0002084_abnormal_developmental_patter0.87011327
91MP0009642_abnormal_blood_homeostasis0.86657694
92MP0005645_abnormal_hypothalamus_physiol0.86191116
93MP0005551_abnormal_eye_electrophysiolog0.85692510
94MP0001293_anophthalmia0.84806682
95MP0004484_altered_response_of0.84057749
96MP0002161_abnormal_fertility/fecundity0.83441897
97MP0000427_abnormal_hair_cycle0.83014458
98MP0005395_other_phenotype0.81889166
99MP0002876_abnormal_thyroid_physiology0.81303294
100MP0005266_abnormal_metabolism0.80895352
101MP0009763_increased_sensitivity_to0.80869519
102MP0005376_homeostasis/metabolism_phenot0.80761653
103MP0003787_abnormal_imprinting0.80302460
104MP0004197_abnormal_fetal_growth/weight/0.79802478
105MP0008469_abnormal_protein_level0.79731525
106MP0003121_genomic_imprinting0.79650793
107MP0001119_abnormal_female_reproductive0.79378271
108MP0004043_abnormal_pH_regulation0.78091886
109MP0005084_abnormal_gallbladder_morpholo0.77268539
110MP0003221_abnormal_cardiomyocyte_apopto0.76807391
111MP0000350_abnormal_cell_proliferation0.75904087
112MP0005174_abnormal_tail_pigmentation0.75887070
113MP0003136_yellow_coat_color0.75743845
114MP0005334_abnormal_fat_pad0.74719962
115MP0002332_abnormal_exercise_endurance0.74540725
116MP0002269_muscular_atrophy0.74193531
117MP0003693_abnormal_embryo_hatching0.74112939
118MP0000604_amyloidosis0.73416726
119MP0003646_muscle_fatigue0.72434216
120MP0000631_abnormal_neuroendocrine_gland0.71042190
121MP0008007_abnormal_cellular_replicative0.70996049
122MP0005535_abnormal_body_temperature0.70381606
123MP0001324_abnormal_eye_pigmentation0.70003063
124MP0002102_abnormal_ear_morphology0.69319696
125MP0005408_hypopigmentation0.68874905
126MP0005369_muscle_phenotype0.68531039
127MP0002166_altered_tumor_susceptibility0.68487281
128MP0002086_abnormal_extraembryonic_tissu0.66634960
129MP0001984_abnormal_olfaction0.66149140
130MP0005330_cardiomyopathy0.66054974
131MP0005389_reproductive_system_phenotype0.65722564
132MP0010368_abnormal_lymphatic_system0.65460115
133MP0009764_decreased_sensitivity_to0.63366914
134MP0009672_abnormal_birth_weight0.63186187
135MP0002254_reproductive_system_inflammat0.62823885
136MP0002136_abnormal_kidney_physiology0.61087563
137MP0004264_abnormal_extraembryonic_tissu0.54540413
138MP0005058_abnormal_lysosome_morphology0.54072162
139MP0009765_abnormal_xenobiotic_induced0.52990680
140MP0003953_abnormal_hormone_level0.49837109
141MP0009115_abnormal_fat_cell0.49809628
142MP0005448_abnormal_energy_balance0.49336510
143MP0000747_muscle_weakness0.48804636
144MP0004147_increased_porphyrin_level0.45958235
145MP0002970_abnormal_white_adipose0.45697572
146MP0000230_abnormal_systemic_arterial0.45655064
147MP0002132_abnormal_respiratory_system0.43998420
148MP0002796_impaired_skin_barrier0.42696250
149MP0004185_abnormal_adipocyte_glucose0.41985308
150MP0009053_abnormal_anal_canal0.41965907
151MP0003329_amyloid_beta_deposits0.41434826
152MP0004782_abnormal_surfactant_physiolog0.39236062
153MP0001944_abnormal_pancreas_morphology0.38494225
154MP0001765_abnormal_ion_homeostasis0.38156745
155MP0001542_abnormal_bone_strength0.36805435
156MP0001881_abnormal_mammary_gland0.36176254
157MP0003699_abnormal_female_reproductive0.35961812
158MP0000358_abnormal_cell_content/0.35651681
159MP0005375_adipose_tissue_phenotype0.35574530
160MP0004084_abnormal_cardiac_muscle0.35109592
161MP0004381_abnormal_hair_follicle0.33811991
162MP0004036_abnormal_muscle_relaxation0.33704013
163MP0009384_cardiac_valve_regurgitation0.33635424
164MP0002928_abnormal_bile_duct0.33234010
165MP0005410_abnormal_fertilization0.32217755
166MP0000639_abnormal_adrenal_gland0.31161262
167MP0000647_abnormal_sebaceous_gland0.30656735
168MP0006138_congestive_heart_failure0.30515184

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.29680362
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.29486764
3Hyperglycinemia (HP:0002154)6.12252888
4Hyperglycinuria (HP:0003108)5.77591309
5Deep venous thrombosis (HP:0002625)5.70995114
6Xanthomatosis (HP:0000991)5.61222187
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.56302313
8Hypobetalipoproteinemia (HP:0003563)5.49709741
9Abnormality of glycine metabolism (HP:0010895)5.34330320
10Abnormality of serine family amino acid metabolism (HP:0010894)5.34330320
11Prolonged partial thromboplastin time (HP:0003645)5.26066810
12Hyperlipoproteinemia (HP:0010980)4.85217541
13Hyperammonemia (HP:0001987)4.70654315
14Complement deficiency (HP:0004431)4.49422289
15Hypoglycemic coma (HP:0001325)4.45452790
16Hypolipoproteinemia (HP:0010981)4.40923640
17Ketosis (HP:0001946)4.31648292
18Gout (HP:0001997)4.19336388
19Abnormality of fatty-acid metabolism (HP:0004359)4.16922696
20Abnormality of serum amino acid levels (HP:0003112)4.11530530
21Hypoalphalipoproteinemia (HP:0003233)4.00329575
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.98518952
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.98178177
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78964494
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.76013115
26Epidermoid cyst (HP:0200040)3.75702429
27Fat malabsorption (HP:0002630)3.73040489
28Abnormality of the common coagulation pathway (HP:0010990)3.72699417
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70789334
30Abnormality of methionine metabolism (HP:0010901)3.68236506
31Joint hemorrhage (HP:0005261)3.52686635
32Ketoacidosis (HP:0001993)3.45133987
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.44833125
34Dicarboxylic aciduria (HP:0003215)3.44833125
35Abnormality of the intrinsic pathway (HP:0010989)3.43982364
36Muscle fiber inclusion bodies (HP:0100299)3.35603142
37Abnormality of purine metabolism (HP:0004352)3.30539940
38Fair hair (HP:0002286)3.27077303
39Abnormality of nucleobase metabolism (HP:0010932)3.25867517
40Lethargy (HP:0001254)3.19890246
41Nemaline bodies (HP:0003798)3.18099346
42Abnormality of pyrimidine metabolism (HP:0004353)3.16522671
43Conjugated hyperbilirubinemia (HP:0002908)3.15543564
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.14218914
45Volvulus (HP:0002580)3.13079307
46Abnormality of complement system (HP:0005339)3.11779913
47Chromsome breakage (HP:0040012)3.10040586
48Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01003587
49Metabolic acidosis (HP:0001942)2.94728958
50Increased purine levels (HP:0004368)2.94410123
51Hyperuricemia (HP:0002149)2.94410123
52Muscle hypertrophy of the lower extremities (HP:0008968)2.88073771
53Delayed CNS myelination (HP:0002188)2.87396132
54Hyperbilirubinemia (HP:0002904)2.84892366
55Generalized aminoaciduria (HP:0002909)2.84424879
56Hypercholesterolemia (HP:0003124)2.80187621
57Abnormality of alanine metabolism (HP:0010916)2.78838579
58Hyperalaninemia (HP:0003348)2.78838579
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.78838579
60Steatorrhea (HP:0002570)2.78425274
61Azoospermia (HP:0000027)2.74380192
62Birth length less than 3rd percentile (HP:0003561)2.71370787
63Papillary thyroid carcinoma (HP:0002895)2.71319489
64Methylmalonic acidemia (HP:0002912)2.70741568
65Gonadotropin excess (HP:0000837)2.68120035
66Calf muscle hypertrophy (HP:0008981)2.68007647
67Spontaneous abortion (HP:0005268)2.64877959
68Hyperglycemia (HP:0003074)2.62132144
69Cerebral edema (HP:0002181)2.59059088
70Exercise-induced muscle cramps (HP:0003710)2.58983012
71Hyperkalemia (HP:0002153)2.57078109
72Proximal tubulopathy (HP:0000114)2.53082666
73Myocardial infarction (HP:0001658)2.52198743
74Irritability (HP:0000737)2.49859096
75Pancreatic cysts (HP:0001737)2.48669637
76Hypoglycemic seizures (HP:0002173)2.46972009
77Hepatocellular carcinoma (HP:0001402)2.44914295
78Skin nodule (HP:0200036)2.37586189
79Rhabdomyosarcoma (HP:0002859)2.37130589
80Abnormality of the renal collecting system (HP:0004742)2.33497716
81Brushfield spots (HP:0001088)2.30167441
82Abnormality of the labia minora (HP:0012880)2.29917084
83Nausea (HP:0002018)2.29098039
84Duplicated collecting system (HP:0000081)2.28692533
85Abnormality of chromosome stability (HP:0003220)2.26406189
86Hyperinsulinemic hypoglycemia (HP:0000825)2.26195117
87Vascular calcification (HP:0004934)2.25775123
88Abnormal biliary tract physiology (HP:0012439)2.22854712
89Bile duct proliferation (HP:0001408)2.22854712
90Abnormal spermatogenesis (HP:0008669)2.22825652
91Vomiting (HP:0002013)2.22614476
92Oligodactyly (hands) (HP:0001180)2.22591720
93Acanthocytosis (HP:0001927)2.22260985
94Malnutrition (HP:0004395)2.17707854
95Abnormal cartilage morphology (HP:0002763)2.17627857
96Generalized hypopigmentation of hair (HP:0011358)2.17566291
97Chronic hepatic failure (HP:0100626)2.16383830
98Abnormality of the renal cortex (HP:0011035)2.16279545
99Renal cortical cysts (HP:0000803)2.13607659
100Spastic diplegia (HP:0001264)2.12296052
101Hypochromic microcytic anemia (HP:0004840)2.11143791
102Abnormality of urine glucose concentration (HP:0011016)2.09720179
103Glycosuria (HP:0003076)2.09720179
104Type II lissencephaly (HP:0007260)2.09142728
105Pancreatitis (HP:0001733)2.07442187
106Abnormality of the left ventricular outflow tract (HP:0011103)2.07017900
107Subaortic stenosis (HP:0001682)2.07017900
108Rimmed vacuoles (HP:0003805)2.05485087
109Late onset (HP:0003584)2.05379891
110Abnormality of the pons (HP:0007361)2.05372752
111Aplasia/Hypoplasia of the tibia (HP:0005772)2.03469994
112Short tibia (HP:0005736)2.03315989
113Sensorimotor neuropathy (HP:0007141)2.03103116
114Aplasia/Hypoplasia of the uvula (HP:0010293)2.01220356
115Hypoplasia of the pons (HP:0012110)2.01048516
116Meckel diverticulum (HP:0002245)2.00644656
117Lip pit (HP:0100267)1.99936422
118Abnormal gallbladder morphology (HP:0012437)1.98862479
119Cardiovascular calcification (HP:0011915)1.98554352
120Systemic lupus erythematosus (HP:0002725)1.97266510
121Abnormality of B cell number (HP:0010975)1.95486363
122Rhabdomyolysis (HP:0003201)1.95478593
123Atrioventricular block (HP:0001678)1.95024005
124Cholelithiasis (HP:0001081)1.95017748
125Myoglobinuria (HP:0002913)1.94845462
126Progressive inability to walk (HP:0002505)1.93154102
127Tetraplegia (HP:0002445)1.90998562
128Increased hepatocellular lipid droplets (HP:0006565)1.90871188
129Neonatal onset (HP:0003623)1.90645474
130Abnormality of the ileum (HP:0001549)1.90069682
131Polycythemia (HP:0001901)1.89665558
132Megaloblastic anemia (HP:0001889)1.88841490
133Methylmalonic aciduria (HP:0012120)1.87364297
134Exercise-induced myalgia (HP:0003738)1.85258514
135Abnormality of the preputium (HP:0100587)1.84502271
136Enlarged kidneys (HP:0000105)1.84350846
137Distal arthrogryposis (HP:0005684)1.84160875
138Glomerulonephritis (HP:0000099)1.83294963
139Increased intramyocellular lipid droplets (HP:0012240)1.83185154
140Increased serum lactate (HP:0002151)1.80842875
141Abnormality of proline metabolism (HP:0010907)1.80693941
142Hydroxyprolinuria (HP:0003080)1.80693941
143Nephroblastoma (Wilms tumor) (HP:0002667)1.80278194
144Abnormality of midbrain morphology (HP:0002418)1.79052698
145Molar tooth sign on MRI (HP:0002419)1.79052698
146Elevated hepatic transaminases (HP:0002910)1.78740355
147Opisthotonus (HP:0002179)1.78697886
148Spastic paraparesis (HP:0002313)1.78612187
149Abnormal finger flexion creases (HP:0006143)1.78474801
150Alkalosis (HP:0001948)1.77214071
151Pancreatic fibrosis (HP:0100732)1.76903674
152Abnormality of transition element cation homeostasis (HP:0011030)1.76182966
153Esophageal varix (HP:0002040)1.75664325
154Female pseudohermaphroditism (HP:0010458)1.74557708
155Abnormal enzyme/coenzyme activity (HP:0012379)1.73976118
156Hepatic necrosis (HP:0002605)1.73098543
1573-Methylglutaconic aciduria (HP:0003535)1.72740213
158Acute hepatic failure (HP:0006554)1.72388680
159Abnormal lung lobation (HP:0002101)1.71909364
160Thyroid carcinoma (HP:0002890)1.71680453
161Impulsivity (HP:0100710)1.70933356
162Nephronophthisis (HP:0000090)1.67497033
163Embryonal renal neoplasm (HP:0011794)1.67336558
164Abnormality of chromosome segregation (HP:0002916)1.66083151
165Abnormality of vitamin metabolism (HP:0100508)1.65626616
166Gaze-evoked nystagmus (HP:0000640)1.65534237
167Cerebellar dysplasia (HP:0007033)1.65214502
168Neoplasm of striated muscle (HP:0009728)1.64876286
169Abnormality of the vitamin B12 metabolism (HP:0004341)1.63424672
170Inability to walk (HP:0002540)1.62089003
171Anterior segment dysgenesis (HP:0007700)1.61655606
172Sloping forehead (HP:0000340)1.60850293
173Lipid accumulation in hepatocytes (HP:0006561)1.60482170
174Pendular nystagmus (HP:0012043)1.59400386
175Abnormality of vitamin B metabolism (HP:0004340)1.58804026
176Lissencephaly (HP:0001339)1.58113564
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.57327043
178Lactic acidosis (HP:0003128)1.57045637
179Ovarian neoplasm (HP:0100615)1.55846198
180Supernumerary spleens (HP:0009799)1.54582401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.50980656
2PDK43.93975677
3PDK33.93975677
4CDC73.13150481
5BUB13.06823125
6FGFR43.00672909
7SRPK12.85844873
8PDK22.80572763
9ERN12.37614319
10WEE12.34593155
11SIK12.30909178
12BMPR1B2.26808953
13MKNK22.20396956
14STK38L2.11759255
15PINK12.05886653
16EIF2AK12.04722940
17INSRR2.03954139
18NEK11.88004387
19AKT31.85968831
20MKNK11.85205182
21LATS11.81459943
22TRIM281.79855755
23TLK11.69259615
24ACVR1B1.67273425
25TRIB31.66499649
26FRK1.65621319
27NUAK11.62624687
28MAP3K31.57083256
29TAOK11.55536357
30NEK21.52531823
31BRSK21.51333256
32CDK191.49441391
33STK391.49427596
34TAOK31.45714972
35ERBB41.44019548
36WNK31.42599092
37MST41.42300989
38PBK1.41267289
39STK161.40563365
40PASK1.40332433
41MAPK111.39749044
42MAP4K21.37281650
43EPHA21.36738585
44PHKG21.36593932
45PHKG11.36593932
46OXSR11.34887487
47VRK11.34737665
48CDK31.34572626
49FLT31.32506715
50PIK3CG1.31412161
51PLK41.28414721
52MAP3K131.26951754
53NME21.26411771
54NEK91.25653612
55STK31.20959341
56OBSCN1.10263163
57MAP3K91.10226023
58PRKAA11.09618547
59TTK1.07845841
60EIF2AK31.05379711
61KDR1.04895456
62MST1R1.04051629
63PNCK1.03822247
64PKN21.02751214
65GRK11.00695146
66DYRK30.99788759
67MAP3K100.97944929
68TYK20.94956307
69PRKAA20.93693639
70TSSK60.92629702
71IRAK30.92151348
72MAP2K30.90844012
73MAP3K40.89420095
74MAPK130.88828488
75CHEK20.88447870
76ZAK0.88425543
77PIK3CA0.88359116
78ABL20.87101840
79NEK60.82376596
80CDK40.81343961
81ATM0.80741433
82TGFBR10.80634554
83ATR0.79262354
84WNK40.77339939
85TIE10.76686840
86PLK10.75458319
87MAP2K40.72762060
88LATS20.72304372
89PRKCI0.71558206
90CLK10.69654102
91VRK20.68433245
92CHEK10.68195821
93BRD40.67521696
94RPS6KB10.67363920
95MAP3K50.65880011
96BRSK10.65780460
97CDK70.63303834
98RPS6KB20.63283830
99TGFBR20.62824853
100JAK20.60968477
101RAF10.59205885
102ERBB30.54008873
103MTOR0.53814026
104PLK30.53718380
105PIM10.53701258
106PLK20.52998102
107MARK30.52401456
108PDPK10.52340955
109CSNK1G10.51741010
110EPHA30.51057848
111EIF2AK20.49531785
112MAPK150.48832815
113PRKACG0.48344950
114CCNB10.47510687
115RPS6KA40.47272897
116AURKB0.46580121
117FGFR10.46075850
118MAP2K20.44909077
119GSK3A0.44453485
120BCR0.44253526
121CDK60.44239215
122BRAF0.44198420
123CDK10.44191380
124CDK120.43892019
125FGFR20.43726793
126PTK60.43104309
127ERBB20.42854253
128MAPK40.42517240
129CAMK1G0.41687778
130STK380.40045927
131CDK20.40038358
132STK240.39969545
133TEC0.39915211
134PDK10.38457927
135PRKCQ0.38319674
136MUSK0.38215740
137CAMK2G0.37674984
138CSNK1D0.37442895
139MET0.36952331
140SGK20.35952743
141MAPKAPK30.34941562
142DYRK1B0.34431012
143JAK10.33629595
144PRKCZ0.32441176
145AURKA0.32152069
146TTN0.30948767
147MAPK120.30578584
148TAOK20.28641006
149MAP2K10.28430167
150MAP3K110.27900136
151MAP3K80.27857194
152ZAP700.27098650
153CSNK2A10.25968625
154CSNK1G30.25925205
155MAP2K60.25517632
156MELK0.25204196
157CSNK1E0.23786177
158NLK0.23598623
159MAP3K70.22253505

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.82729195
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.06453658
3Nitrogen metabolism_Homo sapiens_hsa009102.95740205
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94103003
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.81051634
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78052334
7Basal transcription factors_Homo sapiens_hsa030222.74471415
8Fatty acid degradation_Homo sapiens_hsa000712.71700532
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68986241
10Vitamin B6 metabolism_Homo sapiens_hsa007502.57059995
11Arginine biosynthesis_Homo sapiens_hsa002202.54698475
12Homologous recombination_Homo sapiens_hsa034402.49301270
13Tryptophan metabolism_Homo sapiens_hsa003802.43762923
14Propanoate metabolism_Homo sapiens_hsa006402.41860161
15Mismatch repair_Homo sapiens_hsa034302.37661778
16RNA degradation_Homo sapiens_hsa030182.25496247
17Butanoate metabolism_Homo sapiens_hsa006502.22240215
18Complement and coagulation cascades_Homo sapiens_hsa046102.20041184
19DNA replication_Homo sapiens_hsa030302.15662669
20Fanconi anemia pathway_Homo sapiens_hsa034602.15587411
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15231219
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.06442132
23Peroxisome_Homo sapiens_hsa041462.05983923
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04557159
25Fatty acid metabolism_Homo sapiens_hsa012121.99884905
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96451358
27Nucleotide excision repair_Homo sapiens_hsa034201.88413653
28PPAR signaling pathway_Homo sapiens_hsa033201.85309578
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.82269919
30Folate biosynthesis_Homo sapiens_hsa007901.78739383
31beta-Alanine metabolism_Homo sapiens_hsa004101.78388479
32Cell cycle_Homo sapiens_hsa041101.77607056
33Selenocompound metabolism_Homo sapiens_hsa004501.74713037
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65395489
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.64180435
36Pyruvate metabolism_Homo sapiens_hsa006201.59772031
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59707471
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58942062
39Carbon metabolism_Homo sapiens_hsa012001.57895357
40Histidine metabolism_Homo sapiens_hsa003401.57600185
41mRNA surveillance pathway_Homo sapiens_hsa030151.57211529
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54265005
43Biosynthesis of amino acids_Homo sapiens_hsa012301.49646798
44Chemical carcinogenesis_Homo sapiens_hsa052041.49027455
45Non-homologous end-joining_Homo sapiens_hsa034501.45479464
46Base excision repair_Homo sapiens_hsa034101.44228946
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43879430
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.43526286
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42989600
50Caffeine metabolism_Homo sapiens_hsa002321.41949928
51Retinol metabolism_Homo sapiens_hsa008301.41910278
52Spliceosome_Homo sapiens_hsa030401.37554938
53Fatty acid elongation_Homo sapiens_hsa000621.33526714
54Phenylalanine metabolism_Homo sapiens_hsa003601.30496039
55Vitamin digestion and absorption_Homo sapiens_hsa049771.27977576
56Sulfur metabolism_Homo sapiens_hsa009201.27155176
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.26114840
58Staphylococcus aureus infection_Homo sapiens_hsa051501.23150604
59Phototransduction_Homo sapiens_hsa047441.22706283
60Fat digestion and absorption_Homo sapiens_hsa049751.22002818
61Tyrosine metabolism_Homo sapiens_hsa003501.18125445
62Bile secretion_Homo sapiens_hsa049761.14260741
63Starch and sucrose metabolism_Homo sapiens_hsa005001.14164121
64Oocyte meiosis_Homo sapiens_hsa041141.12103941
65Sulfur relay system_Homo sapiens_hsa041221.10927437
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.10410469
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07768344
68Arginine and proline metabolism_Homo sapiens_hsa003301.05624072
69Pentose phosphate pathway_Homo sapiens_hsa000301.05028553
70Dorso-ventral axis formation_Homo sapiens_hsa043201.02464889
71ABC transporters_Homo sapiens_hsa020100.94817064
72Glycerolipid metabolism_Homo sapiens_hsa005610.92553122
73Steroid biosynthesis_Homo sapiens_hsa001000.89615553
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86934736
75One carbon pool by folate_Homo sapiens_hsa006700.85764562
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84359529
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83240159
78Glutathione metabolism_Homo sapiens_hsa004800.82007873
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79257004
80Ribosome_Homo sapiens_hsa030100.78304470
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74409307
82Ether lipid metabolism_Homo sapiens_hsa005650.70093519
83Fatty acid biosynthesis_Homo sapiens_hsa000610.69317947
84Lysine degradation_Homo sapiens_hsa003100.68452049
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65296437
86Regulation of autophagy_Homo sapiens_hsa041400.64331313
87Metabolic pathways_Homo sapiens_hsa011000.63256441
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.60263992
89Fructose and mannose metabolism_Homo sapiens_hsa000510.55540801
90Ovarian steroidogenesis_Homo sapiens_hsa049130.47452033
91Olfactory transduction_Homo sapiens_hsa047400.44950272
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42422454
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41196534
94Galactose metabolism_Homo sapiens_hsa000520.41120804
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40031924
96FoxO signaling pathway_Homo sapiens_hsa040680.38282680
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37550548
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36193367
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33587466
100Linoleic acid metabolism_Homo sapiens_hsa005910.31545357
101Proteasome_Homo sapiens_hsa030500.30010786
102Pyrimidine metabolism_Homo sapiens_hsa002400.30009469
103mTOR signaling pathway_Homo sapiens_hsa041500.29691505
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.29672946
105Insulin resistance_Homo sapiens_hsa049310.27064997
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26343751
107Systemic lupus erythematosus_Homo sapiens_hsa053220.25863379
108Huntingtons disease_Homo sapiens_hsa050160.24143362
109Prion diseases_Homo sapiens_hsa050200.19935396
110Glucagon signaling pathway_Homo sapiens_hsa049220.18953530
111AMPK signaling pathway_Homo sapiens_hsa041520.16794273
112RNA polymerase_Homo sapiens_hsa030200.16168877
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11578157
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09802649
115Purine metabolism_Homo sapiens_hsa002300.06846087
116Circadian rhythm_Homo sapiens_hsa047100.04821824
117RNA transport_Homo sapiens_hsa030130.03351675
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01464582
119Lysosome_Homo sapiens_hsa04142-0.1531176
120Protein digestion and absorption_Homo sapiens_hsa04974-0.1376320
121p53 signaling pathway_Homo sapiens_hsa04115-0.1348379
122Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0953381
123Protein export_Homo sapiens_hsa03060-0.0905521
124Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0817788
125Insulin signaling pathway_Homo sapiens_hsa04910-0.0322862
126Renin-angiotensin system_Homo sapiens_hsa04614-0.0297751
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0274382

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