CLRN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron remodeling (GO:0016322)8.61633460
2axon ensheathment in central nervous system (GO:0032291)6.43408206
3central nervous system myelination (GO:0022010)6.43408206
4meiotic chromosome segregation (GO:0045132)4.94863340
5retinal cone cell development (GO:0046549)4.74582513
6regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.73642425
7long-chain fatty acid biosynthetic process (GO:0042759)4.68876042
8presynaptic membrane assembly (GO:0097105)4.43379235
9detection of light stimulus involved in sensory perception (GO:0050962)4.43135969
10detection of light stimulus involved in visual perception (GO:0050908)4.43135969
11presynaptic membrane organization (GO:0097090)4.28223963
12behavioral response to nicotine (GO:0035095)4.13054506
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.07955072
14synapsis (GO:0007129)3.91351401
15regulation of meiosis I (GO:0060631)3.89716575
16protein K11-linked deubiquitination (GO:0035871)3.81619005
17fucose catabolic process (GO:0019317)3.74855752
18L-fucose metabolic process (GO:0042354)3.74855752
19L-fucose catabolic process (GO:0042355)3.74855752
20neuron cell-cell adhesion (GO:0007158)3.73875104
21tryptophan metabolic process (GO:0006568)3.72454046
22indolalkylamine metabolic process (GO:0006586)3.69331680
23postsynaptic membrane organization (GO:0001941)3.65688868
24tryptophan catabolic process (GO:0006569)3.60472225
25indole-containing compound catabolic process (GO:0042436)3.60472225
26indolalkylamine catabolic process (GO:0046218)3.60472225
27phosphatidylinositol acyl-chain remodeling (GO:0036149)3.59680857
28regulation of pigment cell differentiation (GO:0050932)3.57838983
29prenylation (GO:0097354)3.54031113
30protein prenylation (GO:0018342)3.54031113
31neuron maturation (GO:0042551)3.53522692
32limb bud formation (GO:0060174)3.53302335
33resolution of meiotic recombination intermediates (GO:0000712)3.51943961
34negative regulation of execution phase of apoptosis (GO:1900118)3.48404704
35male meiosis (GO:0007140)3.46793147
36kynurenine metabolic process (GO:0070189)3.46542604
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.46115923
38C4-dicarboxylate transport (GO:0015740)3.42788274
39piRNA metabolic process (GO:0034587)3.41246607
40ensheathment of neurons (GO:0007272)3.39124272
41axon ensheathment (GO:0008366)3.39124272
42cellular ketone body metabolic process (GO:0046950)3.38676008
43myelination (GO:0042552)3.34417510
44replication fork processing (GO:0031297)3.29038804
45axoneme assembly (GO:0035082)3.28547885
46DNA double-strand break processing (GO:0000729)3.28044746
47oligodendrocyte differentiation (GO:0048709)3.26134811
48positive regulation of prostaglandin secretion (GO:0032308)3.26097170
49superoxide anion generation (GO:0042554)3.25923852
50regulation of glucokinase activity (GO:0033131)3.25487181
51regulation of hexokinase activity (GO:1903299)3.25487181
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.23843613
53regulation of translation, ncRNA-mediated (GO:0045974)3.23843613
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.23843613
55reciprocal meiotic recombination (GO:0007131)3.21038873
56reciprocal DNA recombination (GO:0035825)3.21038873
57fatty acid elongation (GO:0030497)3.20339825
58phosphatidylserine acyl-chain remodeling (GO:0036150)3.19847871
59magnesium ion transport (GO:0015693)3.18835683
60one-carbon compound transport (GO:0019755)3.18365190
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18174039
62estrogen biosynthetic process (GO:0006703)3.16202063
63photoreceptor cell development (GO:0042461)3.14956831
64cerebral cortex radially oriented cell migration (GO:0021799)3.12489516
65import into cell (GO:0098657)3.11787922
66ketone body metabolic process (GO:1902224)3.10955860
67nerve growth factor signaling pathway (GO:0038180)3.07119561
68L-amino acid import (GO:0043092)3.06565526
69negative regulation of protein localization to cell surface (GO:2000009)3.03300747
70coenzyme catabolic process (GO:0009109)2.98115915
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97768040
72positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.97182320
73somatic hypermutation of immunoglobulin genes (GO:0016446)2.97042317
74somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97042317
75regulation of timing of cell differentiation (GO:0048505)2.96174621
76serotonin receptor signaling pathway (GO:0007210)2.94244327
77male meiosis I (GO:0007141)2.93542673
78cranial nerve structural organization (GO:0021604)2.93376170
79regulation of collateral sprouting (GO:0048670)2.92690922
80eye photoreceptor cell development (GO:0042462)2.90559359
81peptidyl-histidine modification (GO:0018202)2.87698711
82recombinational repair (GO:0000725)2.85358422
83double-strand break repair via homologous recombination (GO:0000724)2.84746203
84neural tube formation (GO:0001841)2.84118591
85positive regulation of vasculogenesis (GO:2001214)2.83030312
86glycerophospholipid catabolic process (GO:0046475)2.82531351
87aggressive behavior (GO:0002118)2.81529452
88positive regulation of fatty acid transport (GO:2000193)2.81314434
89interkinetic nuclear migration (GO:0022027)2.80649579
90benzene-containing compound metabolic process (GO:0042537)2.80090739
91rRNA methylation (GO:0031167)2.79133775
92phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.78119612
93phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77904311
94gamma-aminobutyric acid transport (GO:0015812)2.77751102
95transmission of nerve impulse (GO:0019226)2.77549646
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.77416187
97glutamate receptor signaling pathway (GO:0007215)2.77178722
98developmental pigmentation (GO:0048066)2.77026274
99cell wall macromolecule catabolic process (GO:0016998)2.76168820
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76007878
101negative regulation of neurotransmitter transport (GO:0051589)2.75384613
102facial nerve structural organization (GO:0021612)2.75144626
103water-soluble vitamin biosynthetic process (GO:0042364)2.73474219
104righting reflex (GO:0060013)2.72029234
105rRNA catabolic process (GO:0016075)2.71894505
106positive regulation of action potential (GO:0045760)2.70396943
107regulation of prostaglandin secretion (GO:0032306)2.69655070
108indole-containing compound metabolic process (GO:0042430)2.69473762
109regulation of rhodopsin mediated signaling pathway (GO:0022400)2.69436272
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.68667311
111DNA deamination (GO:0045006)2.67258637
112retina layer formation (GO:0010842)2.67210103
113dicarboxylic acid catabolic process (GO:0043649)2.66749557
114nucleotide transmembrane transport (GO:1901679)2.64165101
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.64157485
116* photoreceptor cell maintenance (GO:0045494)2.63228204
117histone H2B ubiquitination (GO:0033523)2.62006615
118photoreceptor cell differentiation (GO:0046530)2.60153798
119eye photoreceptor cell differentiation (GO:0001754)2.60153798
120neuronal action potential propagation (GO:0019227)2.58853716
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.58774508
122parental behavior (GO:0060746)2.58383562
123kidney morphogenesis (GO:0060993)2.55226961
124regulation of heat generation (GO:0031650)2.54567238
125rhodopsin mediated signaling pathway (GO:0016056)2.53702159
126meiosis I (GO:0007127)2.52651132
127G-protein coupled receptor internalization (GO:0002031)2.52513853
128startle response (GO:0001964)2.52358321
129* visual perception (GO:0007601)2.51903416
130multicellular organism reproduction (GO:0032504)2.51239390
131epithelial cilium movement (GO:0003351)2.51110163
132negative regulation of mast cell activation (GO:0033004)2.49691061
133rRNA modification (GO:0000154)2.49224407
134protein localization to synapse (GO:0035418)2.49048054
135* sensory perception of light stimulus (GO:0050953)2.48499477
136negative regulation of protein oligomerization (GO:0032460)2.47836845
137regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47453366
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47150621
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46797021
140positive regulation of organic acid transport (GO:0032892)2.45859761
141alanine transport (GO:0032328)2.45295367
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44006449
143chromosome organization involved in meiosis (GO:0070192)2.43533913
144mesenchymal cell differentiation involved in renal system development (GO:2001012)2.43249976
145mesenchymal cell differentiation involved in kidney development (GO:0072161)2.43249976
146negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.43118526
147short-term memory (GO:0007614)2.42408462
148mannosylation (GO:0097502)2.42142417
149cilium morphogenesis (GO:0060271)2.41427629
150sphingoid metabolic process (GO:0046519)2.41166264
151gene silencing by RNA (GO:0031047)2.40747377
152regulation of platelet aggregation (GO:0090330)2.40349304
153protein K6-linked ubiquitination (GO:0085020)2.39986501
154regulation of inositol phosphate biosynthetic process (GO:0010919)2.39870214
155neuron recognition (GO:0008038)2.38751557
156neuronal action potential (GO:0019228)2.38676556
157vocalization behavior (GO:0071625)2.37646411
158cyclic nucleotide catabolic process (GO:0009214)2.36228184
159negative regulation of neurotransmitter secretion (GO:0046929)2.36006317
160GPI anchor metabolic process (GO:0006505)2.35704853
161amino acid import (GO:0043090)2.35642243
162regulation of development, heterochronic (GO:0040034)2.33422437
163isoprenoid biosynthetic process (GO:0008299)2.32972783
164cranial nerve development (GO:0021545)2.31849381
165positive regulation of interleukin-17 production (GO:0032740)2.31786072
166cellular response to epinephrine stimulus (GO:0071872)2.29521909
167cAMP-mediated signaling (GO:0019933)2.27941965
168neuronal ion channel clustering (GO:0045161)2.27699190
169response to pheromone (GO:0019236)2.27512113
170response to redox state (GO:0051775)2.27246998
171regulation of somitogenesis (GO:0014807)2.27041348
172positive regulation of synapse assembly (GO:0051965)2.23298521
173GPI anchor biosynthetic process (GO:0006506)2.22904393
174cranial nerve morphogenesis (GO:0021602)2.22716723
175calcium ion import (GO:0070509)2.22129016
176positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.21913741
177response to epinephrine (GO:0071871)2.20732396
178positive regulation of interleukin-10 production (GO:0032733)2.19286118
179organ growth (GO:0035265)2.19149220
180calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.18083063
181negative regulation of synaptic transmission (GO:0050805)2.16876903
182positive regulation of protein kinase C signaling (GO:0090037)2.16798383
183synaptic transmission, glutamatergic (GO:0035249)2.15624942
184membrane assembly (GO:0071709)2.14496018
185reflex (GO:0060004)2.13820803
186negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.13191488
187adult walking behavior (GO:0007628)2.12990930
188response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.12801780
189protein heterotetramerization (GO:0051290)2.11403914
190lateral sprouting from an epithelium (GO:0060601)2.11226486
191preassembly of GPI anchor in ER membrane (GO:0016254)2.11215883
192enteric nervous system development (GO:0048484)2.10735138
193neuron-neuron synaptic transmission (GO:0007270)2.10084468
194regulation of glutamate secretion (GO:0014048)2.07967481
195nonmotile primary cilium assembly (GO:0035058)2.07680136
196regulation of respiratory system process (GO:0044065)2.07314242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.90927243
2GBX2_23144817_ChIP-Seq_PC3_Human3.77874106
3ZNF274_21170338_ChIP-Seq_K562_Hela3.44625813
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82731784
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71980130
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58266023
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42933079
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.41648277
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41613061
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.40360629
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37744816
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34324586
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33024035
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26722864
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26722864
16EWS_26573619_Chip-Seq_HEK293_Human2.12991514
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.11263032
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07489475
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06343633
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.03531682
21TAF15_26573619_Chip-Seq_HEK293_Human2.00069473
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.96696561
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95250384
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94915346
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94742400
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94089101
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92030087
28BCAT_22108803_ChIP-Seq_LS180_Human1.91811162
29AR_21572438_ChIP-Seq_LNCaP_Human1.91250849
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.90297412
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85443003
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.83190867
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78420680
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77671497
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75674016
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74426920
37IRF1_19129219_ChIP-ChIP_H3396_Human1.71857795
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70919698
39P300_19829295_ChIP-Seq_ESCs_Human1.69513546
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67426919
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64664728
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61686802
43RNF2_27304074_Chip-Seq_NSC_Mouse1.60182560
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60032560
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59292814
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58959759
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54561101
48* NANOG_18555785_Chip-Seq_ESCs_Mouse1.53826123
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53503733
50CBP_20019798_ChIP-Seq_JUKART_Human1.52800190
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52800190
52* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52638691
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51244174
54* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50273097
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.49769770
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48976397
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.48350041
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.48169475
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.47575646
60* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47291517
61AR_25329375_ChIP-Seq_VCAP_Human1.45609991
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44214838
63TCF4_22108803_ChIP-Seq_LS180_Human1.42723142
64DROSHA_22980978_ChIP-Seq_HELA_Human1.42222094
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41841121
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41552391
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40580984
68* E2F1_18555785_Chip-Seq_ESCs_Mouse1.39780482
69IGF1R_20145208_ChIP-Seq_DFB_Human1.38336365
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38054496
71* CMYC_18555785_Chip-Seq_ESCs_Mouse1.37560896
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37501346
73P53_22387025_ChIP-Seq_ESCs_Mouse1.37332888
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.37196329
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.36441029
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.35685885
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35626142
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35232087
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35178289
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34658743
81* SMAD4_21799915_ChIP-Seq_A2780_Human1.34459612
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34106298
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33422357
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33298835
85NANOG_19829295_ChIP-Seq_ESCs_Human1.33067625
86SOX2_19829295_ChIP-Seq_ESCs_Human1.33067625
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31741841
88VDR_22108803_ChIP-Seq_LS180_Human1.31650609
89P300_18555785_Chip-Seq_ESCs_Mouse1.31187863
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30710438
91REST_21632747_ChIP-Seq_MESCs_Mouse1.29686668
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29421202
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26556937
94FUS_26573619_Chip-Seq_HEK293_Human1.25701522
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.25437715
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25437715
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25220478
98CDX2_22108803_ChIP-Seq_LS180_Human1.24852629
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24580359
100RUNX2_22187159_ChIP-Seq_PCA_Human1.24075500
101TP53_18474530_ChIP-ChIP_U2OS_Human1.23104089
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23027967
103NMYC_18555785_Chip-Seq_ESCs_Mouse1.21219449
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.20556084
105TP53_22573176_ChIP-Seq_HFKS_Human1.19759464
106ER_23166858_ChIP-Seq_MCF-7_Human1.19719142
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18438741
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.17847192
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17667930
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17667930
111MYC_18940864_ChIP-ChIP_HL60_Human1.17150636
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16653935
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.16597263
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.16480595
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16440128
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.15799130
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.15721380
118AR_20517297_ChIP-Seq_VCAP_Human1.14753008
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13619789
120* PU1_27457419_Chip-Seq_LIVER_Mouse1.13429105
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.13260873
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12621802
123ZFX_18555785_Chip-Seq_ESCs_Mouse1.12500708
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12346570
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12328314
126AHR_22903824_ChIP-Seq_MCF-7_Human1.12235812
127STAT3_23295773_ChIP-Seq_U87_Human1.12121832
128KDM2B_26808549_Chip-Seq_REH_Human1.12059933
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.10686080
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09546568
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.08181671
132TCF4_23295773_ChIP-Seq_U87_Human1.06278948
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06101931
134ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05661661
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.05125739
136NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04005961
137SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03707220
138* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03407282
139NCOR_22424771_ChIP-Seq_293T_Human1.03265461
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02223323
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.01876555
142BP1_19119308_ChIP-ChIP_Hs578T_Human1.01602234
143OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00082525
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99755843
145* RING1B_27294783_Chip-Seq_ESCs_Mouse0.99580463
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98406052
147ETV1_20927104_ChIP-Seq_GIST48_Human0.97682066
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96034949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.74840279
2MP0005409_darkened_coat_color3.61381830
3MP0003136_yellow_coat_color3.21925323
4MP0001188_hyperpigmentation3.01701673
5MP0006292_abnormal_olfactory_placode2.94948168
6MP0008877_abnormal_DNA_methylation2.91440952
7MP0003880_abnormal_central_pattern2.84241022
8MP0005171_absent_coat_pigmentation2.81230158
9MP0001486_abnormal_startle_reflex2.69601195
10MP0000566_synostosis2.50080398
11MP0002102_abnormal_ear_morphology2.48966773
12* MP0004742_abnormal_vestibular_system2.45753352
13MP0000372_irregular_coat_pigmentation2.39534121
14MP0004381_abnormal_hair_follicle2.37836434
15MP0000920_abnormal_myelination2.36935791
16MP0002736_abnormal_nociception_after2.20055487
17MP0001968_abnormal_touch/_nociception2.14372974
18MP0003950_abnormal_plasma_membrane2.13600186
19MP0002735_abnormal_chemical_nociception2.08465455
20MP0008260_abnormal_autophagy2.07393949
21MP0009697_abnormal_copulation2.06348697
22MP0005645_abnormal_hypothalamus_physiol1.94468550
23MP0002272_abnormal_nervous_system1.91673342
24MP0002277_abnormal_respiratory_mucosa1.90086850
25MP0008875_abnormal_xenobiotic_pharmacok1.87854276
26MP0000569_abnormal_digit_pigmentation1.85780413
27MP0003718_maternal_effect1.85192703
28MP0008872_abnormal_physiological_respon1.82315252
29MP0002572_abnormal_emotion/affect_behav1.79547404
30MP0003787_abnormal_imprinting1.79276034
31MP0002837_dystrophic_cardiac_calcinosis1.79149100
32MP0001986_abnormal_taste_sensitivity1.72901876
33MP0009745_abnormal_behavioral_response1.71596946
34MP0001440_abnormal_grooming_behavior1.71432984
35MP0003690_abnormal_glial_cell1.69083629
36MP0004270_analgesia1.69059575
37MP0009046_muscle_twitch1.68818640
38MP0005423_abnormal_somatic_nervous1.66475215
39MP0004859_abnormal_synaptic_plasticity1.62250992
40MP0004885_abnormal_endolymph1.62212037
41* MP0001963_abnormal_hearing_physiology1.60839583
42MP0006276_abnormal_autonomic_nervous1.60771354
43MP0002067_abnormal_sensory_capabilities1.58859049
44MP0002909_abnormal_adrenal_gland1.55817515
45MP0005551_abnormal_eye_electrophysiolog1.55202616
46* MP0000026_abnormal_inner_ear1.54671812
47MP0002064_seizures1.54502406
48MP0000015_abnormal_ear_pigmentation1.53542400
49MP0003011_delayed_dark_adaptation1.53510171
50MP0001905_abnormal_dopamine_level1.52967898
51MP0002063_abnormal_learning/memory/cond1.50571306
52MP0004134_abnormal_chest_morphology1.49472793
53MP0002557_abnormal_social/conspecific_i1.48610262
54MP0000778_abnormal_nervous_system1.48397055
55MP0003635_abnormal_synaptic_transmissio1.47758836
56MP0003938_abnormal_ear_development1.46138878
57MP0000427_abnormal_hair_cycle1.45302474
58MP0005670_abnormal_white_adipose1.45077649
59MP0004043_abnormal_pH_regulation1.44693693
60MP0002160_abnormal_reproductive_system1.43906667
61MP0001485_abnormal_pinna_reflex1.42649755
62MP0001661_extended_life_span1.39908951
63MP0002734_abnormal_mechanical_nocicepti1.39398778
64MP0004142_abnormal_muscle_tone1.38000536
65MP0009379_abnormal_foot_pigmentation1.35306674
66MP0005451_abnormal_body_composition1.33574518
67MP0008995_early_reproductive_senescence1.33166922
68MP0005174_abnormal_tail_pigmentation1.32532883
69MP0003646_muscle_fatigue1.30098382
70MP0001501_abnormal_sleep_pattern1.26152425
71MP0002184_abnormal_innervation1.25419809
72MP0001970_abnormal_pain_threshold1.25079423
73MP0000462_abnormal_digestive_system1.23446676
74MP0001529_abnormal_vocalization1.22828750
75MP0005389_reproductive_system_phenotype1.22827520
76* MP0002752_abnormal_somatic_nervous1.19729367
77MP0008057_abnormal_DNA_replication1.19685762
78MP0000516_abnormal_urinary_system1.19529408
79MP0005367_renal/urinary_system_phenotyp1.19529408
80MP0005085_abnormal_gallbladder_physiolo1.19508333
81MP0003698_abnormal_male_reproductive1.19507233
82MP0002638_abnormal_pupillary_reflex1.18423128
83MP0005646_abnormal_pituitary_gland1.16755907
84MP0002249_abnormal_larynx_morphology1.16370590
85MP0008569_lethality_at_weaning1.16057790
86MP0005365_abnormal_bile_salt1.15223767
87MP0009250_abnormal_appendicular_skeleto1.15075138
88MP0002876_abnormal_thyroid_physiology1.12598951
89MP0000230_abnormal_systemic_arterial1.10667298
90MP0005379_endocrine/exocrine_gland_phen1.10471058
91MP0008058_abnormal_DNA_repair1.10409840
92MP0001929_abnormal_gametogenesis1.10374783
93MP0004147_increased_porphyrin_level1.06847650
94MP0005332_abnormal_amino_acid1.06655699
95MP0005253_abnormal_eye_physiology1.05712808
96MP0001756_abnormal_urination1.04476538
97MP0000049_abnormal_middle_ear1.04441768
98MP0000647_abnormal_sebaceous_gland1.03100508
99MP0003634_abnormal_glial_cell1.02216707
100MP0005395_other_phenotype1.02175127
101MP0005647_abnormal_sex_gland1.01941946
102MP0001502_abnormal_circadian_rhythm1.01881457
103MP0000538_abnormal_urinary_bladder1.01229596
104MP0001545_abnormal_hematopoietic_system1.00642903
105MP0005397_hematopoietic_system_phenotyp1.00642903
106MP0002938_white_spotting0.99590973
107MP0005167_abnormal_blood-brain_barrier0.99559967
108MP0002733_abnormal_thermal_nociception0.99315089
109MP0001764_abnormal_homeostasis0.99143023
110MP0002229_neurodegeneration0.98858478
111MP0003878_abnormal_ear_physiology0.98212681
112MP0005377_hearing/vestibular/ear_phenot0.98212681
113MP0000653_abnormal_sex_gland0.97614169
114MP0002210_abnormal_sex_determination0.95618905
115MP0005084_abnormal_gallbladder_morpholo0.95335455
116MP0010678_abnormal_skin_adnexa0.95238627
117MP0001919_abnormal_reproductive_system0.94997932
118MP0001346_abnormal_lacrimal_gland0.93967618
119* MP0002882_abnormal_neuron_morphology0.93949141
120MP0000631_abnormal_neuroendocrine_gland0.92842063
121MP0004215_abnormal_myocardial_fiber0.92815243
122MP0005391_vision/eye_phenotype0.92576451
123MP0002254_reproductive_system_inflammat0.91961223
124MP0001145_abnormal_male_reproductive0.91707412
125MP0000955_abnormal_spinal_cord0.88917451
126MP0000762_abnormal_tongue_morphology0.86231478
127* MP0002066_abnormal_motor_capabilities/c0.85225867
128MP0008775_abnormal_heart_ventricle0.85065197
129MP0005310_abnormal_salivary_gland0.84223755
130MP0009278_abnormal_bone_marrow0.84015571
131MP0005387_immune_system_phenotype0.82948829
132MP0001790_abnormal_immune_system0.82948829
133MP0002234_abnormal_pharynx_morphology0.82036912
134MP0006072_abnormal_retinal_apoptosis0.81733588
135MP0002138_abnormal_hepatobiliary_system0.80372120
136MP0000383_abnormal_hair_follicle0.80063942
137MP0009764_decreased_sensitivity_to0.79298132
138MP0001119_abnormal_female_reproductive0.78479757
139MP0010329_abnormal_lipoprotein_level0.77661430
140MP0002168_other_aberrant_phenotype0.77539368
141MP0010386_abnormal_urinary_bladder0.77532428
142MP0003122_maternal_imprinting0.76991970
143MP0001984_abnormal_olfaction0.76974513
144MP0003283_abnormal_digestive_organ0.75984783
145MP0002233_abnormal_nose_morphology0.75056321
146MP0001664_abnormal_digestion0.74709247
147MP0003724_increased_susceptibility_to0.74098046
148MP0005195_abnormal_posterior_eye0.72866958
149MP0002751_abnormal_autonomic_nervous0.68478043
150MP0000579_abnormal_nail_morphology0.65366616
151MP0003385_abnormal_body_wall0.64757173
152MP0005386_behavior/neurological_phenoty0.64476992
153MP0004924_abnormal_behavior0.64476992
154MP0003937_abnormal_limbs/digits/tail_de0.64189942
155MP0005410_abnormal_fertilization0.62813868
156MP0004484_altered_response_of0.62533552
157MP0003633_abnormal_nervous_system0.62374080
158MP0003631_nervous_system_phenotype0.62270752
159MP0001851_eye_inflammation0.60779555

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.30315237
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.02568067
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.02568067
4Pancreatic fibrosis (HP:0100732)3.97151117
5Pancreatic cysts (HP:0001737)3.96771297
6Focal motor seizures (HP:0011153)3.96515187
7Peripheral hypomyelination (HP:0007182)3.76511335
8Absent septum pellucidum (HP:0001331)3.67447395
9Upper limb muscle weakness (HP:0003484)3.61294313
10True hermaphroditism (HP:0010459)3.60603762
11Type II lissencephaly (HP:0007260)3.55853360
12White forelock (HP:0002211)3.52486161
13Patchy hypopigmentation of hair (HP:0011365)3.49580200
14Pendular nystagmus (HP:0012043)3.48008844
15* Attenuation of retinal blood vessels (HP:0007843)3.44578860
16Abnormality of the renal cortex (HP:0011035)3.43442884
17* Abnormal rod and cone electroretinograms (HP:0008323)3.40089556
18Ulnar claw (HP:0001178)3.31168520
19* Decreased central vision (HP:0007663)3.29089662
20Molar tooth sign on MRI (HP:0002419)3.23764680
21Abnormality of midbrain morphology (HP:0002418)3.23764680
22Abnormality of the septum pellucidum (HP:0007375)3.21453918
23Decreased circulating renin level (HP:0003351)3.19574753
24Aplasia/Hypoplasia of the tibia (HP:0005772)3.18263005
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.14170459
26Hypoplasia of the fovea (HP:0007750)3.14170459
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.13786122
28Gaze-evoked nystagmus (HP:0000640)3.02549285
29Febrile seizures (HP:0002373)3.00873243
30Abolished electroretinogram (ERG) (HP:0000550)2.99261300
31Nephronophthisis (HP:0000090)2.96440016
32Methylmalonic aciduria (HP:0012120)2.90095087
33Cerebellar dysplasia (HP:0007033)2.87434671
34Segmental peripheral demyelination/remyelination (HP:0003481)2.87155065
35Hemiparesis (HP:0001269)2.85238730
36Intestinal atresia (HP:0011100)2.83819575
37Abnormality of the corticospinal tract (HP:0002492)2.82369200
38* Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82154728
39Neurofibrillary tangles (HP:0002185)2.81433137
40Prostate neoplasm (HP:0100787)2.79186470
41Optic nerve hypoplasia (HP:0000609)2.76031514
42Renal cortical cysts (HP:0000803)2.75294900
43Onion bulb formation (HP:0003383)2.68892362
44Abnormality of the renal medulla (HP:0100957)2.67927282
45Cystic liver disease (HP:0006706)2.65905702
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.65435422
47Absent/shortened dynein arms (HP:0200106)2.65435422
48Hyperglycinuria (HP:0003108)2.63156299
49Abnormality of macular pigmentation (HP:0008002)2.63096573
50Parakeratosis (HP:0001036)2.62562903
51Neoplasm of the adrenal cortex (HP:0100641)2.61779642
52Tubular atrophy (HP:0000092)2.61333958
53Congenital sensorineural hearing impairment (HP:0008527)2.59155402
54Alacrima (HP:0000522)2.55224212
55Abnormal ciliary motility (HP:0012262)2.54559003
56Hypokalemic alkalosis (HP:0001949)2.51069448
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49720230
58Anomalous pulmonary venous return (HP:0010772)2.49195697
59Decreased lacrimation (HP:0000633)2.46902545
60Short tibia (HP:0005736)2.46685865
61Abnormal drinking behavior (HP:0030082)2.43642637
62Polydipsia (HP:0001959)2.43642637
63Osteomalacia (HP:0002749)2.42257655
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.41585204
65Agammaglobulinemia (HP:0004432)2.41394850
66Chronic hepatic failure (HP:0100626)2.41224692
67Medial flaring of the eyebrow (HP:0010747)2.40239716
68Abnormality of the fovea (HP:0000493)2.38829441
69Aplasia cutis congenita (HP:0001057)2.37711775
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.30829904
71Abnormal auditory evoked potentials (HP:0006958)2.30350240
72Abnormal biliary tract physiology (HP:0012439)2.28442248
73Bile duct proliferation (HP:0001408)2.28442248
74Stomach cancer (HP:0012126)2.25221296
75Sensory axonal neuropathy (HP:0003390)2.24308238
76Duplicated collecting system (HP:0000081)2.24077346
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23421644
78Anencephaly (HP:0002323)2.21033966
79* Bony spicule pigmentary retinopathy (HP:0007737)2.19959360
80Chorioretinal atrophy (HP:0000533)2.19283384
81Morphological abnormality of the inner ear (HP:0011390)2.18507059
82Abnormality of the pulmonary veins (HP:0011718)2.18165573
83Colon cancer (HP:0003003)2.17483060
84Abnormality of serine family amino acid metabolism (HP:0010894)2.13688998
85Abnormality of glycine metabolism (HP:0010895)2.13688998
86Abnormality of the renal collecting system (HP:0004742)2.13238159
87Abnormality of incisor morphology (HP:0011063)2.12818354
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12595965
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.10016905
90Xerostomia (HP:0000217)2.09755774
91Focal seizures (HP:0007359)2.08021623
92Abnormal respiratory motile cilium physiology (HP:0012261)2.06587054
93Polyuria (HP:0000103)2.06504225
94Congenital stationary night blindness (HP:0007642)2.06288398
95Conical tooth (HP:0000698)2.05376476
96Sclerocornea (HP:0000647)2.05118735
97Slow saccadic eye movements (HP:0000514)2.04466901
98Prolonged neonatal jaundice (HP:0006579)2.03200853
99Progressive inability to walk (HP:0002505)2.00487533
100Microvesicular hepatic steatosis (HP:0001414)1.99742427
101Abnormality of the labia minora (HP:0012880)1.99559073
102Hyperaldosteronism (HP:0000859)1.98731896
103Recurrent pneumonia (HP:0006532)1.98545991
104Ketosis (HP:0001946)1.97360268
105Constricted visual fields (HP:0001133)1.97243064
106Chromsome breakage (HP:0040012)1.96680328
107Renal salt wasting (HP:0000127)1.95858906
108Retinal dysplasia (HP:0007973)1.95449368
109Lissencephaly (HP:0001339)1.94611504
110Inability to walk (HP:0002540)1.92536873
111Concave nail (HP:0001598)1.91364548
112Hypomagnesemia (HP:0002917)1.90653863
113Cerebral hypomyelination (HP:0006808)1.89816866
114Submucous cleft hard palate (HP:0000176)1.89803822
115Cupped ear (HP:0000378)1.89371474
116Epileptic encephalopathy (HP:0200134)1.89190059
117Craniofacial hyperostosis (HP:0004493)1.88471112
118Dicarboxylic aciduria (HP:0003215)1.88114383
119Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88114383
120Abnormal respiratory motile cilium morphology (HP:0005938)1.87795141
121Abnormal respiratory epithelium morphology (HP:0012253)1.87795141
122Blue irides (HP:0000635)1.87200988
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86833947
124Duplication of thumb phalanx (HP:0009942)1.85925618
125Congenital hepatic fibrosis (HP:0002612)1.85638192
126Chronic obstructive pulmonary disease (HP:0006510)1.85046984
127Obstructive lung disease (HP:0006536)1.85046984
128Metabolic alkalosis (HP:0200114)1.84150421
129Abnormality of the axillary hair (HP:0100134)1.83989167
130Abnormality of secondary sexual hair (HP:0009888)1.83989167
131Corneal dystrophy (HP:0001131)1.83979479
132Absent speech (HP:0001344)1.83950650
133Keratoconus (HP:0000563)1.83938854
134Increased corneal curvature (HP:0100692)1.83938854
135Thyroid-stimulating hormone excess (HP:0002925)1.83676490
136Hypoplasia of the iris (HP:0007676)1.83631846
137Methylmalonic acidemia (HP:0002912)1.83611904
138Chin dimple (HP:0010751)1.83608332
139Ependymoma (HP:0002888)1.83586805
140Nasolacrimal duct obstruction (HP:0000579)1.83150716
141Ketoacidosis (HP:0001993)1.83028165
142Broad-based gait (HP:0002136)1.81167318
143Myelomeningocele (HP:0002475)1.79766842
144Furrowed tongue (HP:0000221)1.79091127
145Decreased motor nerve conduction velocity (HP:0003431)1.78997276
146Severe muscular hypotonia (HP:0006829)1.78758297
147Aplasia involving bones of the upper limbs (HP:0009823)1.78666301
148Aplasia of the phalanges of the hand (HP:0009802)1.78666301
149Aplasia involving bones of the extremities (HP:0009825)1.78666301
150Hypothermia (HP:0002045)1.78272264
151Median cleft lip (HP:0000161)1.78083146
152Severe visual impairment (HP:0001141)1.77502754
1533-Methylglutaconic aciduria (HP:0003535)1.77179557
154Male pseudohermaphroditism (HP:0000037)1.76968862
155Abnormality of the parietal bone (HP:0002696)1.76104816
156Chronic diarrhea (HP:0002028)1.76100827
157Paraparesis (HP:0002385)1.75694819
158Congenital primary aphakia (HP:0007707)1.74895221
159Tubulointerstitial abnormality (HP:0001969)1.74831170
160Abnormality of renin-angiotensin system (HP:0000847)1.74035030
161Supranuclear gaze palsy (HP:0000605)1.73556592
162Abnormality of alanine metabolism (HP:0010916)1.73412421
163Hyperalaninemia (HP:0003348)1.73412421
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73412421
165Inflammation of the large intestine (HP:0002037)1.72438968
166Aplasia/Hypoplasia of the macula (HP:0008059)1.72411061
167Hypoplastic pelvis (HP:0008839)1.71249915
168Gait imbalance (HP:0002141)1.70650013
169Partial agenesis of the corpus callosum (HP:0001338)1.70531903
170Drooling (HP:0002307)1.69883839
171Genital tract atresia (HP:0001827)1.69733233
172Hyperventilation (HP:0002883)1.69589849
173Large for gestational age (HP:0001520)1.69507919
174Hyperglycinemia (HP:0002154)1.69113751
175Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68063243
176Steppage gait (HP:0003376)1.67394604
177Humeroradial synostosis (HP:0003041)1.67109718
178Synostosis involving the elbow (HP:0003938)1.67109718
179Bradycardia (HP:0001662)1.66451679
180Abnormality of the lacrimal duct (HP:0011481)1.66430916
181Aplasia of the musculature (HP:0100854)1.65597090
182Mixed hearing impairment (HP:0000410)1.65547323
183Metaphyseal dysplasia (HP:0100255)1.64361213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.38492629
2CASK5.07907622
3MUSK4.02024162
4MAP4K23.52191627
5NUAK12.95022864
6TNIK2.71919854
7BLK2.68311570
8PKN12.52756427
9STK392.29487155
10MAP3K42.22593010
11INSRR2.21887207
12VRK22.02950825
13GRK11.92691775
14PINK11.91785148
15NTRK31.82966189
16OXSR11.80552809
17BMPR1B1.74670877
18WNK31.66688519
19MST41.65312537
20FGFR21.62355358
21ADRBK21.60397386
22MAP3K131.59157155
23PRPF4B1.51349217
24MAPK131.51076215
25YES11.48156864
26DAPK21.47396752
27CLK11.43398302
28ACVR1B1.39820581
29NEK61.39795440
30MKNK21.38525560
31TAOK31.35790747
32PBK1.35596704
33BMPR21.33200512
34PTK2B1.29989861
35STK161.27592799
36SIK31.25554631
37GRK71.25294009
38MAP3K141.21311917
39TLK11.18697775
40PLK41.14384021
41EIF2AK21.12200758
42VRK11.11950616
43STK31.11530073
44MAP4K11.11028427
45MAPKAPK51.08057498
46BCR1.06811152
47MAP2K71.06801523
48CSNK1A1L1.06163629
49RIPK41.05170247
50FGR1.05047267
51MKNK11.03442716
52CAMK2B1.02484588
53EPHA41.02279938
54MAPK151.00277943
55FES0.99284977
56CAMK2A0.98505181
57PRKD20.95214393
58CDK30.94563257
59SGK2230.94557042
60SGK4940.94557042
61EPHA30.94461106
62PRKCE0.94422747
63CAMK2D0.92865645
64MARK10.92691416
65DYRK20.92102471
66NTRK20.89743017
67CCNB10.87989081
68CDK80.86185289
69TNK20.85964596
70ROCK20.83957419
71CSNK1G30.83469472
72FER0.83327994
73UHMK10.82955193
74MELK0.82204744
75IRAK40.81728923
76BRD40.81084412
77NEK20.80330536
78STK38L0.79985432
79MARK20.78918800
80PAK30.78531116
81PLK30.77643125
82STK110.77596509
83SIK20.76462580
84EPHB10.76229720
85IRAK30.76057612
86TAF10.75870102
87WNK40.75463114
88EIF2AK30.75451619
89CSNK1G10.74663155
90PRKCQ0.73998163
91WNK10.73523449
92MAPK120.73039422
93IRAK10.72375308
94CAMK1G0.72107828
95PNCK0.70301584
96AKT30.70197945
97PIK3CG0.69844404
98PHKG10.69592557
99PHKG20.69592557
100TXK0.69239321
101EIF2AK10.67994508
102PIK3CA0.67047141
103SRPK10.66904155
104KIT0.66707236
105FLT30.64902051
106DYRK1A0.64699123
107PRKG20.62087031
108TRPM70.61731600
109MARK30.60855723
110MAPK70.60711874
111RPS6KA50.60285784
112CAMK2G0.59930386
113CSNK1G20.58710385
114CDK190.58100685
115TIE10.57423399
116CAMK10.57213486
117GRK50.56266843
118PRKAA10.56117165
119PRKG10.55619740
120FYN0.54833628
121ZAK0.54750608
122PRKACA0.52441129
123LYN0.52366664
124TRIM280.51444252
125CDK50.50878800
126CSNK1D0.47750679
127IKBKB0.46558732
128BRSK20.46313949
129PRKCI0.44864643
130JAK30.44830759
131CAMKK20.44827664
132NLK0.44689964
133PRKCG0.44377351
134RPS6KB10.44310715
135SGK10.43731016
136NME10.42826077
137PRKD10.42734586
138PRKAA20.41518518
139IRAK20.40438977
140CSNK1A10.39974579
141CSK0.39148590
142ADRBK10.37473010
143PLK20.37111410
144CAMK1D0.36873696
145PLK10.35695154
146LATS10.33093147
147PRKCA0.31892098
148MAP3K120.31626512
149PRKCZ0.31333280
150PDK20.29920287

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.67504841
2Butanoate metabolism_Homo sapiens_hsa006502.70517482
3Nicotine addiction_Homo sapiens_hsa050332.67999207
4Propanoate metabolism_Homo sapiens_hsa006402.56058625
5Nitrogen metabolism_Homo sapiens_hsa009102.43617551
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.29549998
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.28452725
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21649174
9Ether lipid metabolism_Homo sapiens_hsa005652.07104032
10Fatty acid elongation_Homo sapiens_hsa000622.05840844
11Steroid biosynthesis_Homo sapiens_hsa001002.02423086
12Tryptophan metabolism_Homo sapiens_hsa003802.01934137
13Axon guidance_Homo sapiens_hsa043602.00577137
14Phototransduction_Homo sapiens_hsa047441.97904938
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91122627
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90951682
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89866338
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89516919
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89076992
20Morphine addiction_Homo sapiens_hsa050321.84052794
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.83794093
22Serotonergic synapse_Homo sapiens_hsa047261.82233828
23Caffeine metabolism_Homo sapiens_hsa002321.81873624
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.81252324
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78908108
26Glutamatergic synapse_Homo sapiens_hsa047241.77062090
27Basal transcription factors_Homo sapiens_hsa030221.73709038
28Taste transduction_Homo sapiens_hsa047421.70161599
29Sphingolipid metabolism_Homo sapiens_hsa006001.54858761
30Arachidonic acid metabolism_Homo sapiens_hsa005901.52997615
31One carbon pool by folate_Homo sapiens_hsa006701.50844756
32Regulation of autophagy_Homo sapiens_hsa041401.50250727
33Linoleic acid metabolism_Homo sapiens_hsa005911.41373170
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39332662
35Fatty acid degradation_Homo sapiens_hsa000711.37553593
36GABAergic synapse_Homo sapiens_hsa047271.34239887
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32444799
38Calcium signaling pathway_Homo sapiens_hsa040201.31129066
39Peroxisome_Homo sapiens_hsa041461.30289552
40beta-Alanine metabolism_Homo sapiens_hsa004101.30274541
41Oxidative phosphorylation_Homo sapiens_hsa001901.29458486
42Selenocompound metabolism_Homo sapiens_hsa004501.29373684
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28662422
44Rheumatoid arthritis_Homo sapiens_hsa053231.28340821
45Circadian entrainment_Homo sapiens_hsa047131.24746342
46Salivary secretion_Homo sapiens_hsa049701.18209584
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16442613
48Chemical carcinogenesis_Homo sapiens_hsa052041.15075298
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10126449
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09608911
51Histidine metabolism_Homo sapiens_hsa003401.09276706
52Long-term depression_Homo sapiens_hsa047301.04712631
53Olfactory transduction_Homo sapiens_hsa047401.04044747
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03473527
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02600209
56Fatty acid metabolism_Homo sapiens_hsa012121.02449327
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00608930
58Autoimmune thyroid disease_Homo sapiens_hsa053200.99394216
59African trypanosomiasis_Homo sapiens_hsa051430.98842904
60Vitamin digestion and absorption_Homo sapiens_hsa049770.94290728
61RNA degradation_Homo sapiens_hsa030180.92564263
62Vitamin B6 metabolism_Homo sapiens_hsa007500.91847244
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.91033295
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87815421
65Alzheimers disease_Homo sapiens_hsa050100.86673394
66Lysine degradation_Homo sapiens_hsa003100.85976500
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85433578
68Glycerolipid metabolism_Homo sapiens_hsa005610.84388402
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83407689
70Cholinergic synapse_Homo sapiens_hsa047250.80336615
71Ovarian steroidogenesis_Homo sapiens_hsa049130.80131366
72Malaria_Homo sapiens_hsa051440.80028213
73Hematopoietic cell lineage_Homo sapiens_hsa046400.78796890
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78288175
75Dorso-ventral axis formation_Homo sapiens_hsa043200.75845343
76Collecting duct acid secretion_Homo sapiens_hsa049660.75260995
77ABC transporters_Homo sapiens_hsa020100.75260695
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75162590
79Ras signaling pathway_Homo sapiens_hsa040140.75093432
80Retinol metabolism_Homo sapiens_hsa008300.74824817
81Circadian rhythm_Homo sapiens_hsa047100.73540584
82RNA polymerase_Homo sapiens_hsa030200.73471990
83Renin secretion_Homo sapiens_hsa049240.73194985
84Gastric acid secretion_Homo sapiens_hsa049710.72821521
85B cell receptor signaling pathway_Homo sapiens_hsa046620.71157914
86Insulin secretion_Homo sapiens_hsa049110.71148582
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.70890819
88cAMP signaling pathway_Homo sapiens_hsa040240.70452182
89Other glycan degradation_Homo sapiens_hsa005110.68984002
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.67307406
91Phagosome_Homo sapiens_hsa041450.66691429
92Cocaine addiction_Homo sapiens_hsa050300.66396652
93Sulfur metabolism_Homo sapiens_hsa009200.65835911
94MAPK signaling pathway_Homo sapiens_hsa040100.63824249
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63619366
96Graft-versus-host disease_Homo sapiens_hsa053320.63379607
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.63265478
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.62916480
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.62528334
100Arginine and proline metabolism_Homo sapiens_hsa003300.61094678
101Cardiac muscle contraction_Homo sapiens_hsa042600.60783128
102Chemokine signaling pathway_Homo sapiens_hsa040620.60608187
103Glutathione metabolism_Homo sapiens_hsa004800.59945386
104Amphetamine addiction_Homo sapiens_hsa050310.59718474
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59213240
106Metabolic pathways_Homo sapiens_hsa011000.59104722
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57786857
108Pancreatic secretion_Homo sapiens_hsa049720.57660762
109Homologous recombination_Homo sapiens_hsa034400.57255708
110Mineral absorption_Homo sapiens_hsa049780.55238784
111Non-homologous end-joining_Homo sapiens_hsa034500.55047953
112Oxytocin signaling pathway_Homo sapiens_hsa049210.54911581
113Primary immunodeficiency_Homo sapiens_hsa053400.54073507
114ErbB signaling pathway_Homo sapiens_hsa040120.53930157
115Purine metabolism_Homo sapiens_hsa002300.53816658
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53236777
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52720416
118Choline metabolism in cancer_Homo sapiens_hsa052310.52029393
119Protein export_Homo sapiens_hsa030600.51378027
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51118599
121Dopaminergic synapse_Homo sapiens_hsa047280.50833392
122Parkinsons disease_Homo sapiens_hsa050120.50288409
123PPAR signaling pathway_Homo sapiens_hsa033200.49537645
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49495640
125Fat digestion and absorption_Homo sapiens_hsa049750.49436543
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49055992
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.49016567
128Wnt signaling pathway_Homo sapiens_hsa043100.47087135
129Fanconi anemia pathway_Homo sapiens_hsa034600.46666910
130Asthma_Homo sapiens_hsa053100.45947824
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45912922
132Fatty acid biosynthesis_Homo sapiens_hsa000610.44164653
133Staphylococcus aureus infection_Homo sapiens_hsa051500.43889600
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42516656
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42268341
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41780688
137Allograft rejection_Homo sapiens_hsa053300.40944153
138Inositol phosphate metabolism_Homo sapiens_hsa005620.39244329
139Type I diabetes mellitus_Homo sapiens_hsa049400.38717103
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38130572
141Proteasome_Homo sapiens_hsa030500.35859997
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.35207986
143N-Glycan biosynthesis_Homo sapiens_hsa005100.34418137

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