

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | intestinal absorption (GO:0050892) | 8.86800441 |
| 2 | angiotensin maturation (GO:0002003) | 7.44609491 |
| 3 | epoxygenase P450 pathway (GO:0019373) | 7.16940863 |
| 4 | intestinal cholesterol absorption (GO:0030299) | 7.12319468 |
| 5 | regulation of guanylate cyclase activity (GO:0031282) | 6.79529177 |
| 6 | drug transmembrane transport (GO:0006855) | 6.46401368 |
| 7 | drug catabolic process (GO:0042737) | 6.18180292 |
| 8 | fat-soluble vitamin biosynthetic process (GO:0042362) | 6.12347188 |
| 9 | drug transport (GO:0015893) | 6.01199935 |
| 10 | cellular glucuronidation (GO:0052695) | 5.90494392 |
| 11 | uronic acid metabolic process (GO:0006063) | 5.75857873 |
| 12 | glucuronate metabolic process (GO:0019585) | 5.75857873 |
| 13 | actin filament depolymerization (GO:0030042) | 5.64833395 |
| 14 | modified amino acid transport (GO:0072337) | 5.59119514 |
| 15 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 5.18849655 |
| 16 | flavonoid metabolic process (GO:0009812) | 5.18259488 |
| 17 | urate metabolic process (GO:0046415) | 5.15445440 |
| 18 | positive regulation of guanylate cyclase activity (GO:0031284) | 5.13956248 |
| 19 | lysine metabolic process (GO:0006553) | 5.11250477 |
| 20 | lysine catabolic process (GO:0006554) | 5.11250477 |
| 21 | urea metabolic process (GO:0019627) | 5.06518950 |
| 22 | urea cycle (GO:0000050) | 5.04548209 |
| 23 | vitamin A metabolic process (GO:0006776) | 4.95919525 |
| 24 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 4.91977160 |
| 25 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 4.91977160 |
| 26 | endocrine process (GO:0050886) | 4.91977160 |
| 27 | adhesion of symbiont to host cell (GO:0044650) | 4.81515820 |
| 28 | virion attachment to host cell (GO:0019062) | 4.81515820 |
| 29 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 4.73784878 |
| 30 | phosphate ion transport (GO:0006817) | 4.67638424 |
| 31 | nitrogen cycle metabolic process (GO:0071941) | 4.64931834 |
| 32 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 4.64154191 |
| 33 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 4.64154191 |
| 34 | sulfate transmembrane transport (GO:1902358) | 4.57126159 |
| 35 | renal absorption (GO:0070293) | 4.56102296 |
| 36 | sulfur compound transport (GO:0072348) | 4.52508544 |
| 37 | renal system process involved in regulation of blood volume (GO:0001977) | 4.49860181 |
| 38 | regulation of cellular extravasation (GO:0002691) | 4.45901329 |
| 39 | very-low-density lipoprotein particle assembly (GO:0034379) | 4.40627243 |
| 40 | regulation of systemic arterial blood pressure (GO:0003073) | 4.37790652 |
| 41 | exogenous drug catabolic process (GO:0042738) | 4.36507720 |
| 42 | phosphate ion transmembrane transport (GO:0035435) | 4.35791640 |
| 43 | organic cation transport (GO:0015695) | 4.32673567 |
| 44 | cysteine metabolic process (GO:0006534) | 4.24259262 |
| 45 | peptide catabolic process (GO:0043171) | 4.23675676 |
| 46 | homocysteine metabolic process (GO:0050667) | 4.21483477 |
| 47 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 4.16916009 |
| 48 | ethanol oxidation (GO:0006069) | 4.14329839 |
| 49 | nonribosomal peptide biosynthetic process (GO:0019184) | 4.13747053 |
| 50 | digestive system process (GO:0022600) | 4.13534827 |
| 51 | regulation of cGMP biosynthetic process (GO:0030826) | 4.13344841 |
| 52 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.13263034 |
| 53 | excretion (GO:0007588) | 4.11613031 |
| 54 | regulation of bile acid biosynthetic process (GO:0070857) | 4.11238417 |
| 55 | transepithelial transport (GO:0070633) | 4.03748283 |
| 56 | glutathione biosynthetic process (GO:0006750) | 4.03529197 |
| 57 | alkaloid metabolic process (GO:0009820) | 3.95607787 |
| 58 | antibacterial humoral response (GO:0019731) | 3.93885025 |
| 59 | NADH metabolic process (GO:0006734) | 3.92176692 |
| 60 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.91683207 |
| 61 | polyol transport (GO:0015791) | 3.89927243 |
| 62 | bile acid metabolic process (GO:0008206) | 3.88964084 |
| 63 | oligosaccharide catabolic process (GO:0009313) | 3.83027904 |
| 64 | regulation of vitamin metabolic process (GO:0030656) | 3.82986252 |
| 65 | adhesion of symbiont to host (GO:0044406) | 3.81857411 |
| 66 | antimicrobial humoral response (GO:0019730) | 3.81570519 |
| 67 | positive regulation of pseudopodium assembly (GO:0031274) | 3.80967948 |
| 68 | bicarbonate transport (GO:0015701) | 3.79163388 |
| 69 | response to phenylpropanoid (GO:0080184) | 3.77734959 |
| 70 | arginine metabolic process (GO:0006525) | 3.77621369 |
| 71 | fructose metabolic process (GO:0006000) | 3.75701846 |
| 72 | sulfate transport (GO:0008272) | 3.72827238 |
| 73 | regulation of cholesterol homeostasis (GO:2000188) | 3.68836504 |
| 74 | glycosphingolipid catabolic process (GO:0046479) | 3.68331051 |
| 75 | positive regulation of respiratory burst (GO:0060267) | 3.67246340 |
| 76 | glycolipid catabolic process (GO:0019377) | 3.64788696 |
| 77 | peptide hormone processing (GO:0016486) | 3.60838463 |
| 78 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.60816843 |
| 79 | glucose 6-phosphate metabolic process (GO:0051156) | 3.57906250 |
| 80 | quaternary ammonium group transport (GO:0015697) | 3.51975548 |
| 81 | cellular response to hepatocyte growth factor stimulus (GO:0035729) | 3.51149279 |
| 82 | response to hepatocyte growth factor (GO:0035728) | 3.51149279 |
| 83 | negative regulation of sterol transport (GO:0032372) | 3.50875153 |
| 84 | negative regulation of cholesterol transport (GO:0032375) | 3.50875153 |
| 85 | hormone catabolic process (GO:0042447) | 3.50717369 |
| 86 | renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) | 3.42123219 |
| 87 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.42047271 |
| 88 | omega-hydroxylase P450 pathway (GO:0097267) | 3.41063335 |
| 89 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 3.40915581 |
| 90 | positive regulation of lipid catabolic process (GO:0050996) | 3.40912156 |
| 91 | digestion (GO:0007586) | 3.40423940 |
| 92 | regulation of pseudopodium assembly (GO:0031272) | 3.40288042 |
| 93 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.40185371 |
| 94 | regulation of cGMP metabolic process (GO:0030823) | 3.39954191 |
| 95 | O-glycan processing (GO:0016266) | 3.39737363 |
| 96 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.34507673 |
| 97 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.34507673 |
| 98 | hydrogen peroxide catabolic process (GO:0042744) | 3.33971557 |
| 99 | lipoprotein metabolic process (GO:0042157) | 3.31990143 |
| 100 | regulation of triglyceride catabolic process (GO:0010896) | 3.31712845 |
| 101 | bile acid and bile salt transport (GO:0015721) | 3.31553064 |
| 102 | nucleoside diphosphate biosynthetic process (GO:0009133) | 3.30743153 |
| 103 | vitamin transmembrane transport (GO:0035461) | 3.30156966 |
| 104 | peptide biosynthetic process (GO:0043043) | 3.28574742 |
| 105 | diacylglycerol metabolic process (GO:0046339) | 3.27057216 |
| 106 | glutathione derivative biosynthetic process (GO:1901687) | 3.26482555 |
| 107 | glutathione derivative metabolic process (GO:1901685) | 3.26482555 |
| 108 | short-chain fatty acid metabolic process (GO:0046459) | 3.25648236 |
| 109 | drug metabolic process (GO:0017144) | 3.24896807 |
| 110 | positive regulation of glycoprotein biosynthetic process (GO:0010560) | 3.24374768 |
| 111 | ethanol metabolic process (GO:0006067) | 3.23178099 |
| 112 | vitamin transport (GO:0051180) | 3.22124889 |
| 113 | phenylpropanoid metabolic process (GO:0009698) | 3.18737310 |
| 114 | fat-soluble vitamin metabolic process (GO:0006775) | 3.18149082 |
| 115 | midgut development (GO:0007494) | 3.17675571 |
| 116 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.16180276 |
| 117 | vitamin biosynthetic process (GO:0009110) | 3.15912416 |
| 118 | phosphate ion homeostasis (GO:0055062) | 3.15210279 |
| 119 | trivalent inorganic anion homeostasis (GO:0072506) | 3.15210279 |
| 120 | sulfation (GO:0051923) | 3.11939886 |
| 121 | transcytosis (GO:0045056) | 3.11738112 |
| 122 | cellular carbohydrate catabolic process (GO:0044275) | 3.11383234 |
| 123 | carnitine transport (GO:0015879) | 3.10744230 |
| 124 | amino-acid betaine transport (GO:0015838) | 3.10744230 |
| 125 | plasma lipoprotein particle assembly (GO:0034377) | 3.09505754 |
| 126 | phospholipid efflux (GO:0033700) | 3.09213292 |
| 127 | aspartate family amino acid catabolic process (GO:0009068) | 3.08609707 |
| 128 | vitamin D metabolic process (GO:0042359) | 3.06968482 |
| 129 | sterol homeostasis (GO:0055092) | 3.06295360 |
| 130 | glycosylceramide metabolic process (GO:0006677) | 3.06027950 |
| 131 | cGMP-mediated signaling (GO:0019934) | 3.03357636 |
| 132 | complement activation, classical pathway (GO:0006958) | 3.03309495 |
| 133 | protein-lipid complex assembly (GO:0065005) | 3.03030788 |
| 134 | positive regulation of T cell differentiation in thymus (GO:0033089) | 3.02469916 |
| 135 | glomerular filtration (GO:0003094) | 3.02370675 |
| 136 | glycerol metabolic process (GO:0006071) | 3.01667902 |
| 137 | intestinal epithelial cell development (GO:0060576) | 3.01531640 |
| 138 | glutathione metabolic process (GO:0006749) | 3.01346710 |
| 139 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 2.99667990 |
| 140 | membrane repolarization during action potential (GO:0086011) | 2.99558207 |
| 141 | cholesterol homeostasis (GO:0042632) | 2.98796313 |
| 142 | fatty acid beta-oxidation (GO:0006635) | 2.98123818 |
| 143 | positive regulation of glycoprotein metabolic process (GO:1903020) | 2.97842494 |
| 144 | positive regulation of cGMP biosynthetic process (GO:0030828) | 2.97373366 |
| 145 | epithelial structure maintenance (GO:0010669) | 2.96596667 |
| 146 | protein-lipid complex remodeling (GO:0034368) | 2.95676254 |
| 147 | macromolecular complex remodeling (GO:0034367) | 2.95676254 |
| 148 | plasma lipoprotein particle remodeling (GO:0034369) | 2.95676254 |
| 149 | sulfur amino acid catabolic process (GO:0000098) | 2.95481994 |
| 150 | cellular ketone body metabolic process (GO:0046950) | 2.95066517 |
| 151 | alditol metabolic process (GO:0019400) | 2.94083521 |
| 152 | ceramide catabolic process (GO:0046514) | 2.93734626 |
| 153 | regulation of cholesterol esterification (GO:0010872) | 2.93534231 |
| 154 | drinking behavior (GO:0042756) | 2.92735966 |
| 155 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.92494249 |
| 156 | lipoprotein transport (GO:0042953) | 2.92272994 |
| 157 | response to hydroperoxide (GO:0033194) | 2.91248285 |
| 158 | response to mercury ion (GO:0046689) | 2.91167505 |
| 159 | high-density lipoprotein particle remodeling (GO:0034375) | 2.91089341 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 7.71018185 |
| 2 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 5.19934786 |
| 3 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.83558069 |
| 4 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 3.63277280 |
| 5 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 3.49569912 |
| 6 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 3.27746478 |
| 7 | GATA4_25053715_ChIP-Seq_YYC3_Human | 3.15433911 |
| 8 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 3.14987975 |
| 9 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.95473973 |
| 10 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.89283168 |
| 11 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 2.81414844 |
| 12 | GATA6_25053715_ChIP-Seq_YYC3_Human | 2.74095290 |
| 13 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 2.58545608 |
| 14 | SOX2_20726797_ChIP-Seq_SW620_Human | 2.57738068 |
| 15 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.51898342 |
| 16 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.46235978 |
| 17 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.33159675 |
| 18 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.26773541 |
| 19 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 2.13818057 |
| 20 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.08729694 |
| 21 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.95775916 |
| 22 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.93797743 |
| 23 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.91312041 |
| 24 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.78856849 |
| 25 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.75771833 |
| 26 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.74837847 |
| 27 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.62624082 |
| 28 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.59211756 |
| 29 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.59180909 |
| 30 | VDR_22108803_ChIP-Seq_LS180_Human | 1.58191624 |
| 31 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.56918467 |
| 32 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.56642716 |
| 33 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.56205162 |
| 34 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.55591282 |
| 35 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.53467181 |
| 36 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.52135682 |
| 37 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.49624236 |
| 38 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.49204692 |
| 39 | GATA1_22025678_ChIP-Seq_K562_Human | 1.49192283 |
| 40 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.47330535 |
| 41 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.45111197 |
| 42 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.44029734 |
| 43 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.43610099 |
| 44 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.40106322 |
| 45 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.36461757 |
| 46 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.35981670 |
| 47 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.35190754 |
| 48 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.32164618 |
| 49 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.29267825 |
| 50 | ATF3_27146783_Chip-Seq_COLON_Human | 1.28408494 |
| 51 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.28302185 |
| 52 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.25651981 |
| 53 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.22086317 |
| 54 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.21927663 |
| 55 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.21012962 |
| 56 | GATA2_19941826_ChIP-Seq_K562_Human | 1.20779539 |
| 57 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.20632167 |
| 58 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.19995249 |
| 59 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.18073187 |
| 60 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.16221631 |
| 61 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.16013032 |
| 62 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.12817859 |
| 63 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.11741186 |
| 64 | SA1_27219007_Chip-Seq_Bcells_Human | 1.07352056 |
| 65 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.06993886 |
| 66 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.06488534 |
| 67 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.05701703 |
| 68 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.05312727 |
| 69 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.03494421 |
| 70 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.02714107 |
| 71 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.02509090 |
| 72 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.00959556 |
| 73 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.00560330 |
| 74 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.99204839 |
| 75 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.99031410 |
| 76 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.98900522 |
| 77 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.98523958 |
| 78 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.98211705 |
| 79 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.97540388 |
| 80 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.95455642 |
| 81 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.94502582 |
| 82 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.94335227 |
| 83 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.93753294 |
| 84 | GATA1_19941826_ChIP-Seq_K562_Human | 0.93478395 |
| 85 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.93331478 |
| 86 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.92079503 |
| 87 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.91531044 |
| 88 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.90596140 |
| 89 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90587353 |
| 90 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.90465853 |
| 91 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.89377201 |
| 92 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.88827323 |
| 93 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.88588743 |
| 94 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.88574569 |
| 95 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.87511319 |
| 96 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.87345421 |
| 97 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.86410494 |
| 98 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.84707057 |
| 99 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.84246302 |
| 100 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.83544552 |
| 101 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.83309981 |
| 102 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.82141892 |
| 103 | RXR_22108803_ChIP-Seq_LS180_Human | 0.81352818 |
| 104 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.81297345 |
| 105 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.80941192 |
| 106 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.79951328 |
| 107 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.79491012 |
| 108 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.79001938 |
| 109 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.78974906 |
| 110 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.78790332 |
| 111 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.78358901 |
| 112 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.78358901 |
| 113 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.77355191 |
| 114 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.77018352 |
| 115 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.76798561 |
| 116 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.76622567 |
| 117 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.76528979 |
| 118 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.76376588 |
| 119 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.75751091 |
| 120 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.75744676 |
| 121 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.75523449 |
| 122 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.75388938 |
| 123 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.74453367 |
| 124 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.73810130 |
| 125 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.72907215 |
| 126 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.70974551 |
| 127 | * TP63_23658742_ChIP-Seq_EP156T_Human | 0.70026029 |
| 128 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.69978598 |
| 129 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.69045195 |
| 130 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.68674706 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005360_urolithiasis | 9.30011084 |
| 2 | MP0001666_abnormal_nutrient_absorption | 4.47717965 |
| 3 | MP0004043_abnormal_pH_regulation | 4.00991498 |
| 4 | MP0002139_abnormal_hepatobiliary_system | 3.80855622 |
| 5 | MP0010234_abnormal_vibrissa_follicle | 3.57699613 |
| 6 | MP0004019_abnormal_vitamin_homeostasis | 3.38227267 |
| 7 | MP0005377_hearing/vestibular/ear_phenot | 3.28083791 |
| 8 | MP0003878_abnormal_ear_physiology | 3.28083791 |
| 9 | MP0008875_abnormal_xenobiotic_pharmacok | 3.17923652 |
| 10 | MP0004264_abnormal_extraembryonic_tissu | 3.17905555 |
| 11 | MP0005085_abnormal_gallbladder_physiolo | 3.02869069 |
| 12 | MP0003252_abnormal_bile_duct | 3.02786128 |
| 13 | MP0005332_abnormal_amino_acid | 2.69315283 |
| 14 | MP0000462_abnormal_digestive_system | 2.63206014 |
| 15 | MP0002822_catalepsy | 2.54215245 |
| 16 | MP0009643_abnormal_urine_homeostasis | 2.51496370 |
| 17 | MP0003866_abnormal_defecation | 2.45219199 |
| 18 | MP0001765_abnormal_ion_homeostasis | 2.37270083 |
| 19 | MP0003283_abnormal_digestive_organ | 2.32653929 |
| 20 | MP0005365_abnormal_bile_salt | 2.25574302 |
| 21 | MP0003183_abnormal_peptide_metabolism | 2.13844640 |
| 22 | MP0000538_abnormal_urinary_bladder | 2.12859267 |
| 23 | MP0009840_abnormal_foam_cell | 2.11478083 |
| 24 | MP0005636_abnormal_mineral_homeostasis | 1.93615451 |
| 25 | MP0003300_gastrointestinal_ulcer | 1.84178801 |
| 26 | MP0010329_abnormal_lipoprotein_level | 1.81550320 |
| 27 | MP0001663_abnormal_digestive_system | 1.80397684 |
| 28 | MP0004147_increased_porphyrin_level | 1.79222251 |
| 29 | MP0005409_darkened_coat_color | 1.78836330 |
| 30 | MP0005381_digestive/alimentary_phenotyp | 1.75803015 |
| 31 | MP0002136_abnormal_kidney_physiology | 1.73848133 |
| 32 | MP0001756_abnormal_urination | 1.70868540 |
| 33 | MP0005084_abnormal_gallbladder_morpholo | 1.67330029 |
| 34 | MP0002138_abnormal_hepatobiliary_system | 1.67149632 |
| 35 | MP0000537_abnormal_urethra_morphology | 1.63552204 |
| 36 | MP0010155_abnormal_intestine_physiology | 1.62484741 |
| 37 | MP0002876_abnormal_thyroid_physiology | 1.56874801 |
| 38 | MP0001664_abnormal_digestion | 1.49754048 |
| 39 | MP0005167_abnormal_blood-brain_barrier | 1.48825904 |
| 40 | MP0001873_stomach_inflammation | 1.46944416 |
| 41 | MP0005670_abnormal_white_adipose | 1.39002021 |
| 42 | MP0003191_abnormal_cellular_cholesterol | 1.38290430 |
| 43 | MP0000477_abnormal_intestine_morphology | 1.37293611 |
| 44 | MP0000490_abnormal_crypts_of | 1.36072323 |
| 45 | MP0003195_calcinosis | 1.26815407 |
| 46 | MP0002796_impaired_skin_barrier | 1.26128462 |
| 47 | MP0004782_abnormal_surfactant_physiolog | 1.18821425 |
| 48 | MP0006054_spinal_hemorrhage | 1.14461161 |
| 49 | MP0005451_abnormal_body_composition | 1.13938144 |
| 50 | MP0003806_abnormal_nucleotide_metabolis | 1.07976885 |
| 51 | MP0010352_gastrointestinal_tract_polyps | 1.07945724 |
| 52 | MP0004858_abnormal_nervous_system | 1.06435291 |
| 53 | MP0002089_abnormal_postnatal_growth/wei | 1.05205734 |
| 54 | MP0003705_abnormal_hypodermis_morpholog | 1.04075393 |
| 55 | MP0005319_abnormal_enzyme/_coenzyme | 0.95183143 |
| 56 | MP0001188_hyperpigmentation | 0.94184072 |
| 57 | MP0002118_abnormal_lipid_homeostasis | 0.93201669 |
| 58 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.90853629 |
| 59 | MP0009379_abnormal_foot_pigmentation | 0.88649822 |
| 60 | MP0002971_abnormal_brown_adipose | 0.88593311 |
| 61 | MP0001501_abnormal_sleep_pattern | 0.86702915 |
| 62 | MP0009785_altered_susceptibility_to | 0.85868595 |
| 63 | MP0000609_abnormal_liver_physiology | 0.84878779 |
| 64 | MP0005501_abnormal_skin_physiology | 0.83817964 |
| 65 | MP0000465_gastrointestinal_hemorrhage | 0.81774853 |
| 66 | MP0005535_abnormal_body_temperature | 0.81266023 |
| 67 | MP0003724_increased_susceptibility_to | 0.80470903 |
| 68 | MP0008961_abnormal_basal_metabolism | 0.80331723 |
| 69 | MP0001849_ear_inflammation | 0.78957910 |
| 70 | MP0000230_abnormal_systemic_arterial | 0.78957666 |
| 71 | MP0002254_reproductive_system_inflammat | 0.78363265 |
| 72 | MP0003315_abnormal_perineum_morphology | 0.76405313 |
| 73 | MP0002098_abnormal_vibrissa_morphology | 0.75832321 |
| 74 | MP0009384_cardiac_valve_regurgitation | 0.74465697 |
| 75 | MP0008872_abnormal_physiological_respon | 0.71972967 |
| 76 | MP0002166_altered_tumor_susceptibility | 0.70997359 |
| 77 | MP0004270_analgesia | 0.69312188 |
| 78 | MP0005448_abnormal_energy_balance | 0.69275495 |
| 79 | MP0005166_decreased_susceptibility_to | 0.68999491 |
| 80 | MP0001764_abnormal_homeostasis | 0.67835774 |
| 81 | MP0009115_abnormal_fat_cell | 0.67751346 |
| 82 | MP0000467_abnormal_esophagus_morphology | 0.67205745 |
| 83 | MP0005058_abnormal_lysosome_morphology | 0.66994073 |
| 84 | MP0010678_abnormal_skin_adnexa | 0.66825274 |
| 85 | MP0003303_peritoneal_inflammation | 0.65730730 |
| 86 | MP0005025_abnormal_response_to | 0.63424329 |
| 87 | MP0006082_CNS_inflammation | 0.62892223 |
| 88 | MP0009642_abnormal_blood_homeostasis | 0.61914760 |
| 89 | MP0003879_abnormal_hair_cell | 0.61666113 |
| 90 | MP0000604_amyloidosis | 0.61517797 |
| 91 | MP0003638_abnormal_response/metabolism_ | 0.61104740 |
| 92 | MP0000249_abnormal_blood_vessel | 0.59236399 |
| 93 | MP0000678_abnormal_parathyroid_gland | 0.58715246 |
| 94 | MP0002896_abnormal_bone_mineralization | 0.57241055 |
| 95 | MP0003329_amyloid_beta_deposits | 0.56419294 |
| 96 | MP0003436_decreased_susceptibility_to | 0.56376935 |
| 97 | MP0005310_abnormal_salivary_gland | 0.56355334 |
| 98 | MP0004885_abnormal_endolymph | 0.54639268 |
| 99 | MP0004947_skin_inflammation | 0.54063634 |
| 100 | MP0000566_synostosis | 0.53746642 |
| 101 | MP0003868_abnormal_feces_composition | 0.52845247 |
| 102 | MP0001958_emphysema | 0.50994136 |
| 103 | MP0005165_increased_susceptibility_to | 0.50870975 |
| 104 | MP0003453_abnormal_keratinocyte_physiol | 0.50238866 |
| 105 | MP0002078_abnormal_glucose_homeostasis | 0.49869968 |
| 106 | MP0005387_immune_system_phenotype | 0.49801347 |
| 107 | MP0001790_abnormal_immune_system | 0.49801347 |
| 108 | MP0002135_abnormal_kidney_morphology | 0.49680249 |
| 109 | MP0003953_abnormal_hormone_level | 0.48979484 |
| 110 | MP0001216_abnormal_epidermal_layer | 0.48796741 |
| 111 | MP0001485_abnormal_pinna_reflex | 0.48596252 |
| 112 | MP0004484_altered_response_of | 0.48505091 |
| 113 | MP0009333_abnormal_splenocyte_physiolog | 0.48215635 |
| 114 | MP0001881_abnormal_mammary_gland | 0.47845455 |
| 115 | MP0002006_tumorigenesis | 0.46576346 |
| 116 | MP0005334_abnormal_fat_pad | 0.45864661 |
| 117 | MP0009780_abnormal_chondrocyte_physiolo | 0.45351052 |
| 118 | MP0001835_abnormal_antigen_presentation | 0.45010933 |
| 119 | MP0009764_decreased_sensitivity_to | 0.42924522 |
| 120 | MP0006036_abnormal_mitochondrial_physio | 0.42878801 |
| 121 | MP0003941_abnormal_skin_development | 0.42351641 |
| 122 | MP0005266_abnormal_metabolism | 0.40909868 |
| 123 | MP0001845_abnormal_inflammatory_respons | 0.40789956 |
| 124 | MP0003718_maternal_effect | 0.40606541 |
| 125 | MP0009697_abnormal_copulation | 0.39710820 |
| 126 | MP0001191_abnormal_skin_condition | 0.39614422 |
| 127 | MP0008004_abnormal_stomach_pH | 0.37947123 |
| 128 | MP0005666_abnormal_adipose_tissue | 0.37623924 |
| 129 | MP0008469_abnormal_protein_level | 0.37275112 |
| 130 | MP0009053_abnormal_anal_canal | 0.37174712 |
| 131 | MP0000470_abnormal_stomach_morphology | 0.36356122 |
| 132 | MP0000516_abnormal_urinary_system | 0.35530111 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 6.62034886 |
| 2 | Hyperactive renin-angiotensin system (HP:0000841) | 6.58511285 |
| 3 | Metabolic alkalosis (HP:0200114) | 6.44868510 |
| 4 | Ileus (HP:0002595) | 5.81666592 |
| 5 | Abnormality of chloride homeostasis (HP:0011422) | 5.77349185 |
| 6 | Increased circulating renin level (HP:0000848) | 5.08278046 |
| 7 | Hypomagnesemia (HP:0002917) | 4.65870901 |
| 8 | Hyperglycinuria (HP:0003108) | 4.64329145 |
| 9 | Hypokalemic alkalosis (HP:0001949) | 4.57914071 |
| 10 | Abnormality of proline metabolism (HP:0010907) | 4.57760361 |
| 11 | Hydroxyprolinuria (HP:0003080) | 4.57760361 |
| 12 | Abnormality of magnesium homeostasis (HP:0004921) | 4.53316856 |
| 13 | Systemic lupus erythematosus (HP:0002725) | 4.52319092 |
| 14 | Malnutrition (HP:0004395) | 4.40082706 |
| 15 | Abnormal urine output (HP:0012590) | 4.26437896 |
| 16 | Gout (HP:0001997) | 4.26183140 |
| 17 | Abnormality of renin-angiotensin system (HP:0000847) | 4.12112473 |
| 18 | Abnormality of renal excretion (HP:0011036) | 4.04641912 |
| 19 | Proximal tubulopathy (HP:0000114) | 3.99277492 |
| 20 | Hyperaldosteronism (HP:0000859) | 3.94542861 |
| 21 | Polyuria (HP:0000103) | 3.91533690 |
| 22 | Abnormality of purine metabolism (HP:0004352) | 3.90791997 |
| 23 | Alkalosis (HP:0001948) | 3.79550297 |
| 24 | Hyperuricemia (HP:0002149) | 3.78213399 |
| 25 | Increased purine levels (HP:0004368) | 3.78213399 |
| 26 | Abnormality of urine glucose concentration (HP:0011016) | 3.74902957 |
| 27 | Glycosuria (HP:0003076) | 3.74902957 |
| 28 | Tetany (HP:0001281) | 3.56339930 |
| 29 | Right ventricular cardiomyopathy (HP:0011663) | 3.54237429 |
| 30 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.52207837 |
| 31 | Abnormality of glycine metabolism (HP:0010895) | 3.52207837 |
| 32 | Autoimmune thrombocytopenia (HP:0001973) | 3.48692264 |
| 33 | Dehydration (HP:0001944) | 3.41944409 |
| 34 | Widely patent fontanelles and sutures (HP:0004492) | 3.18292981 |
| 35 | Complement deficiency (HP:0004431) | 3.17409048 |
| 36 | Conjugated hyperbilirubinemia (HP:0002908) | 3.09956845 |
| 37 | Hypercalciuria (HP:0002150) | 3.08859234 |
| 38 | Hyperphosphaturia (HP:0003109) | 3.05985232 |
| 39 | Nephrolithiasis (HP:0000787) | 3.02363492 |
| 40 | Hypolipoproteinemia (HP:0010981) | 3.02092584 |
| 41 | Cupped ribs (HP:0000887) | 3.01505146 |
| 42 | Renal salt wasting (HP:0000127) | 3.00177220 |
| 43 | Abnormality of complement system (HP:0005339) | 2.99724371 |
| 44 | Steatorrhea (HP:0002570) | 2.99707919 |
| 45 | Abdominal distention (HP:0003270) | 2.97614414 |
| 46 | Abnormal drinking behavior (HP:0030082) | 2.97007411 |
| 47 | Polydipsia (HP:0001959) | 2.97007411 |
| 48 | Acanthocytosis (HP:0001927) | 2.96809567 |
| 49 | Hypokalemia (HP:0002900) | 2.95498397 |
| 50 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.93883300 |
| 51 | Hemorrhage of the eye (HP:0011885) | 2.92574176 |
| 52 | Ketoacidosis (HP:0001993) | 2.89023273 |
| 53 | Chronic diarrhea (HP:0002028) | 2.88486137 |
| 54 | Abnormality of nucleobase metabolism (HP:0010932) | 2.83553698 |
| 55 | Hypobetalipoproteinemia (HP:0003563) | 2.77166927 |
| 56 | Abnormal urine phosphate concentration (HP:0012599) | 2.75346164 |
| 57 | Flat acetabular roof (HP:0003180) | 2.68384017 |
| 58 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.66322242 |
| 59 | Glomerulonephritis (HP:0000099) | 2.62185218 |
| 60 | Metabolic acidosis (HP:0001942) | 2.61028786 |
| 61 | Potter facies (HP:0002009) | 2.58757926 |
| 62 | Facial shape deformation (HP:0011334) | 2.58757926 |
| 63 | Abnormal tarsal ossification (HP:0008369) | 2.55607639 |
| 64 | Villous atrophy (HP:0011473) | 2.55288280 |
| 65 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.55288280 |
| 66 | Fat malabsorption (HP:0002630) | 2.54779077 |
| 67 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.45962445 |
| 68 | Eczematoid dermatitis (HP:0000976) | 2.45925814 |
| 69 | Abnormality of vitamin B metabolism (HP:0004340) | 2.45873568 |
| 70 | Megaloblastic anemia (HP:0001889) | 2.45744107 |
| 71 | Abnormality of potassium homeostasis (HP:0011042) | 2.44927888 |
| 72 | Abnormality of carpal bone ossification (HP:0006257) | 2.43963639 |
| 73 | Generalized aminoaciduria (HP:0002909) | 2.43072877 |
| 74 | Renal tubular acidosis (HP:0001947) | 2.41556649 |
| 75 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.41398833 |
| 76 | Hyperammonemia (HP:0001987) | 2.41279879 |
| 77 | Focal segmental glomerulosclerosis (HP:0000097) | 2.40380871 |
| 78 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.38438788 |
| 79 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.36265812 |
| 80 | Hyperparathyroidism (HP:0000843) | 2.34855061 |
| 81 | Delayed epiphyseal ossification (HP:0002663) | 2.34261944 |
| 82 | Hypophosphatemia (HP:0002148) | 2.31465501 |
| 83 | Congenital sensorineural hearing impairment (HP:0008527) | 2.28980037 |
| 84 | Nephritis (HP:0000123) | 2.28463508 |
| 85 | Confusion (HP:0001289) | 2.28218546 |
| 86 | Abnormality of the 1st metacarpal (HP:0010009) | 2.24011098 |
| 87 | Enlarged epiphyses (HP:0010580) | 2.23877547 |
| 88 | Thin bony cortex (HP:0002753) | 2.21853595 |
| 89 | Posterior subcapsular cataract (HP:0007787) | 2.20253227 |
| 90 | Autoimmune hemolytic anemia (HP:0001890) | 2.20182078 |
| 91 | Cerebral palsy (HP:0100021) | 2.19944174 |
| 92 | Epidermoid cyst (HP:0200040) | 2.18250664 |
| 93 | Ketosis (HP:0001946) | 2.12554865 |
| 94 | Protuberant abdomen (HP:0001538) | 2.09755195 |
| 95 | Vascular calcification (HP:0004934) | 2.09159783 |
| 96 | Adrenal overactivity (HP:0002717) | 2.08263712 |
| 97 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.04697201 |
| 98 | Dicarboxylic aciduria (HP:0003215) | 2.04697201 |
| 99 | Pancreatitis (HP:0001733) | 2.04006904 |
| 100 | Hyponatremia (HP:0002902) | 2.03232419 |
| 101 | Abnormality of sodium homeostasis (HP:0010931) | 1.99352198 |
| 102 | Decreased circulating renin level (HP:0003351) | 1.96312893 |
| 103 | Abnormality of the costochondral junction (HP:0000919) | 1.95702229 |
| 104 | Abnormality of vitamin metabolism (HP:0100508) | 1.95568470 |
| 105 | Vomiting (HP:0002013) | 1.95191688 |
| 106 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.95132016 |
| 107 | Vacuolated lymphocytes (HP:0001922) | 1.93836763 |
| 108 | Irritability (HP:0000737) | 1.92507677 |
| 109 | Gastrointestinal dysmotility (HP:0002579) | 1.92437594 |
| 110 | Nausea (HP:0002018) | 1.90886059 |
| 111 | Intrahepatic cholestasis (HP:0001406) | 1.89605746 |
| 112 | Wide cranial sutures (HP:0010537) | 1.88732195 |
| 113 | Glomerulosclerosis (HP:0000096) | 1.88132858 |
| 114 | Rickets (HP:0002748) | 1.87859180 |
| 115 | Poikilocytosis (HP:0004447) | 1.87273888 |
| 116 | Pigmentary retinal degeneration (HP:0001146) | 1.86315946 |
| 117 | Xanthomatosis (HP:0000991) | 1.85523875 |
| 118 | Abnormal hand bone ossification (HP:0010660) | 1.84843333 |
| 119 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.84104156 |
| 120 | Cardiovascular calcification (HP:0011915) | 1.82915657 |
| 121 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.82775813 |
| 122 | Pili torti (HP:0003777) | 1.82105136 |
| 123 | Late onset (HP:0003584) | 1.82077542 |
| 124 | Abnormal ossification of hand bones (HP:0005921) | 1.81639426 |
| 125 | Goiter (HP:0000853) | 1.79878073 |
| 126 | Hyperphosphatemia (HP:0002905) | 1.79497298 |
| 127 | Growth hormone excess (HP:0000845) | 1.78835150 |
| 128 | Abnormal biliary tract morphology (HP:0012440) | 1.78753666 |
| 129 | Hypotension (HP:0002615) | 1.78685434 |
| 130 | Renal tubular dysfunction (HP:0000124) | 1.77807324 |
| 131 | Palpitations (HP:0001962) | 1.77155104 |
| 132 | Subcapsular cataract (HP:0000523) | 1.77115205 |
| 133 | Gingivitis (HP:0000230) | 1.76653939 |
| 134 | Lethargy (HP:0001254) | 1.75634452 |
| 135 | Abnormal foot bone ossification (HP:0010675) | 1.72093150 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ACVR1B | 7.48966345 |
| 2 | MST1R | 5.54988442 |
| 3 | FRK | 5.06055641 |
| 4 | WNK4 | 4.73375998 |
| 5 | MST4 | 4.65869465 |
| 6 | WNK3 | 4.47340506 |
| 7 | OXSR1 | 4.23688238 |
| 8 | LMTK2 | 4.09008294 |
| 9 | NME1 | 2.70748501 |
| 10 | PRKG2 | 2.51436121 |
| 11 | GRK6 | 2.39701523 |
| 12 | STK39 | 2.35970371 |
| 13 | MAP2K2 | 2.20869152 |
| 14 | RIPK1 | 2.01921258 |
| 15 | MET | 1.93705171 |
| 16 | PTK6 | 1.71147505 |
| 17 | EPHB2 | 1.63167074 |
| 18 | MAP3K2 | 1.58877036 |
| 19 | EPHA2 | 1.55672219 |
| 20 | PIK3CA | 1.49121149 |
| 21 | TYK2 | 1.48750014 |
| 22 | TESK1 | 1.47257216 |
| 23 | STK24 | 1.40401660 |
| 24 | EPHA3 | 1.40122972 |
| 25 | MYLK | 1.35796035 |
| 26 | MAP3K10 | 1.24192656 |
| 27 | NUAK1 | 1.21780696 |
| 28 | PRPF4B | 1.15222862 |
| 29 | ERN1 | 1.10225544 |
| 30 | NEK1 | 1.07015364 |
| 31 | MAP3K11 | 1.06391506 |
| 32 | PDK3 | 1.05323674 |
| 33 | PDK4 | 1.05323674 |
| 34 | TNIK | 1.03172350 |
| 35 | STK38L | 1.02746921 |
| 36 | PTK2 | 1.00292025 |
| 37 | PDK2 | 0.98679926 |
| 38 | FGFR3 | 0.95515377 |
| 39 | PAK4 | 0.95291320 |
| 40 | MAP3K12 | 0.94389471 |
| 41 | PRKCI | 0.94333171 |
| 42 | EPHB1 | 0.90317307 |
| 43 | STK10 | 0.89243979 |
| 44 | MAP2K6 | 0.86144200 |
| 45 | EPHA4 | 0.86067046 |
| 46 | TTK | 0.84545531 |
| 47 | FER | 0.84392629 |
| 48 | MAP3K7 | 0.82576876 |
| 49 | MATK | 0.80380263 |
| 50 | AKT3 | 0.78674175 |
| 51 | WNK1 | 0.78171777 |
| 52 | PRKAA2 | 0.77974066 |
| 53 | LRRK2 | 0.77624769 |
| 54 | NLK | 0.72816440 |
| 55 | MAP2K1 | 0.72021066 |
| 56 | DDR2 | 0.71822089 |
| 57 | MAP3K3 | 0.70403501 |
| 58 | CDC42BPA | 0.70035201 |
| 59 | TAOK1 | 0.69089802 |
| 60 | LATS1 | 0.68884516 |
| 61 | ABL2 | 0.66259310 |
| 62 | MAPK11 | 0.66183533 |
| 63 | ERBB2 | 0.63713209 |
| 64 | KSR2 | 0.63355647 |
| 65 | MAP3K8 | 0.61562887 |
| 66 | BCKDK | 0.60379308 |
| 67 | PRKAA1 | 0.59233722 |
| 68 | TESK2 | 0.59187970 |
| 69 | MAP3K1 | 0.58523052 |
| 70 | BMX | 0.58330349 |
| 71 | CASK | 0.51640325 |
| 72 | PDPK1 | 0.51467720 |
| 73 | BMPR2 | 0.49134765 |
| 74 | RIPK4 | 0.48102039 |
| 75 | PBK | 0.47166064 |
| 76 | IRAK1 | 0.46821132 |
| 77 | TRIB3 | 0.46052982 |
| 78 | RET | 0.45456636 |
| 79 | PAK3 | 0.45035509 |
| 80 | PIM1 | 0.44348416 |
| 81 | SGK223 | 0.43541346 |
| 82 | SGK494 | 0.43541346 |
| 83 | LIMK1 | 0.43467346 |
| 84 | JAK1 | 0.42046335 |
| 85 | DYRK1B | 0.41726521 |
| 86 | FGFR4 | 0.41537308 |
| 87 | JAK2 | 0.41509045 |
| 88 | GSK3A | 0.41081932 |
| 89 | PDGFRA | 0.38904799 |
| 90 | ZAP70 | 0.37166681 |
| 91 | TBK1 | 0.37006577 |
| 92 | CDK6 | 0.35424656 |
| 93 | YES1 | 0.35079688 |
| 94 | FYN | 0.34978388 |
| 95 | SGK3 | 0.34801901 |
| 96 | IRAK3 | 0.31986247 |
| 97 | PRKCA | 0.31859391 |
| 98 | IKBKE | 0.31592222 |
| 99 | CAMK2D | 0.30811206 |
| 100 | PDK1 | 0.29854078 |
| 101 | SMG1 | 0.29634708 |
| 102 | CDK19 | 0.28739730 |
| 103 | GRK1 | 0.28150100 |
| 104 | CSK | 0.28028680 |
| 105 | CSF1R | 0.27608530 |
| 106 | PRKCD | 0.26641616 |
| 107 | CAMK2G | 0.25972263 |
| 108 | MAPKAPK2 | 0.25243932 |
| 109 | PRKACG | 0.24171199 |
| 110 | IGF1R | 0.23904903 |
| 111 | SRC | 0.23612089 |
| 112 | ROCK1 | 0.23304045 |
| 113 | TAOK3 | 0.22947314 |
| 114 | ERBB4 | 0.22529390 |
| 115 | PIM2 | 0.22193136 |
| 116 | CSNK1A1 | 0.22131728 |
| 117 | SCYL2 | 0.21507163 |
| 118 | AKT2 | 0.20822230 |
| 119 | AURKB | 0.20091316 |
| 120 | LYN | 0.19903337 |
| 121 | CAMK2B | 0.18177151 |
| 122 | ICK | 0.17320393 |
| 123 | SIK1 | 0.16950124 |
| 124 | PRKCQ | 0.16238305 |
| 125 | SGK1 | 0.15570832 |
| 126 | DMPK | 0.15500344 |
| 127 | MAPKAPK3 | 0.15448610 |
| 128 | RPS6KA2 | 0.14720128 |
| 129 | NEK6 | 0.14506592 |
| 130 | ITK | 0.14221466 |
| 131 | STK38 | 0.14070720 |
| 132 | STK11 | 0.13429768 |
| 133 | PAK1 | 0.12752205 |
| 134 | PRKCZ | 0.11784434 |
| 135 | MAP4K1 | 0.10885133 |
| 136 | STK3 | 0.10456038 |
| 137 | MAP3K14 | 0.10047997 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mineral absorption_Homo sapiens_hsa04978 | 3.80210342 |
| 2 | Fat digestion and absorption_Homo sapiens_hsa04975 | 3.75953309 |
| 3 | Sulfur metabolism_Homo sapiens_hsa00920 | 3.62244413 |
| 4 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 3.50848133 |
| 5 | Renin-angiotensin system_Homo sapiens_hsa04614 | 3.19627990 |
| 6 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.92804404 |
| 7 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.76289631 |
| 8 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.53030706 |
| 9 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 2.50927820 |
| 10 | Bile secretion_Homo sapiens_hsa04976 | 2.38813182 |
| 11 | Protein digestion and absorption_Homo sapiens_hsa04974 | 2.22503779 |
| 12 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.08197757 |
| 13 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.96935182 |
| 14 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.95422410 |
| 15 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.93767996 |
| 16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.93420499 |
| 17 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.93039393 |
| 18 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.89976453 |
| 19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.89134597 |
| 20 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.86138874 |
| 21 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.82005490 |
| 22 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.80896311 |
| 23 | Galactose metabolism_Homo sapiens_hsa00052 | 1.79323430 |
| 24 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.77932089 |
| 25 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.75551391 |
| 26 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.73384203 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.71061153 |
| 28 | Histidine metabolism_Homo sapiens_hsa00340 | 1.68968240 |
| 29 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.60443801 |
| 30 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.49021200 |
| 31 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.47109393 |
| 32 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.46151820 |
| 33 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.45857109 |
| 34 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.43003554 |
| 35 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.33542699 |
| 36 | Carbon metabolism_Homo sapiens_hsa01200 | 1.25674112 |
| 37 | Peroxisome_Homo sapiens_hsa04146 | 1.23742835 |
| 38 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.22046483 |
| 39 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.21742112 |
| 40 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.17072455 |
| 41 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.10641916 |
| 42 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.06780290 |
| 43 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.03022653 |
| 44 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.01891668 |
| 45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.01485690 |
| 46 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.99206382 |
| 47 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.97686704 |
| 48 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.94061065 |
| 49 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.91562507 |
| 50 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.86086280 |
| 51 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.85682329 |
| 52 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.81960002 |
| 53 | Asthma_Homo sapiens_hsa05310 | 0.80093150 |
| 54 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.75324971 |
| 55 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.75221788 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.74451321 |
| 57 | Sulfur relay system_Homo sapiens_hsa04122 | 0.73790566 |
| 58 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.67130706 |
| 59 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64548817 |
| 60 | Lysine degradation_Homo sapiens_hsa00310 | 0.63372707 |
| 61 | Other glycan degradation_Homo sapiens_hsa00511 | 0.62852933 |
| 62 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.62502837 |
| 63 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.62276973 |
| 64 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.62188666 |
| 65 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.61954846 |
| 66 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.60171322 |
| 67 | ABC transporters_Homo sapiens_hsa02010 | 0.59874735 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.56801134 |
| 69 | Tight junction_Homo sapiens_hsa04530 | 0.56142807 |
| 70 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.53440934 |
| 71 | Allograft rejection_Homo sapiens_hsa05330 | 0.50717537 |
| 72 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.49589470 |
| 73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48043786 |
| 74 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.47970544 |
| 75 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.46223458 |
| 76 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.45572134 |
| 77 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.42941153 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41605700 |
| 79 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.41207763 |
| 80 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40615691 |
| 81 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.38699070 |
| 82 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.37951208 |
| 83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.34702180 |
| 84 | Parkinsons disease_Homo sapiens_hsa05012 | 0.33083217 |
| 85 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.32263942 |
| 86 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.30937615 |
| 87 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.30061369 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | 0.29119496 |
| 89 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.29010182 |
| 90 | Alzheimers disease_Homo sapiens_hsa05010 | 0.27968497 |
| 91 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.27874099 |
| 92 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27462439 |
| 93 | Hepatitis C_Homo sapiens_hsa05160 | 0.27170481 |
| 94 | Insulin resistance_Homo sapiens_hsa04931 | 0.26374134 |
| 95 | Renin secretion_Homo sapiens_hsa04924 | 0.23467408 |
| 96 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.23342961 |
| 97 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.21254603 |
| 98 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.20574050 |
| 99 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.19715639 |
| 100 | Pertussis_Homo sapiens_hsa05133 | 0.18377473 |
| 101 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.18036328 |
| 102 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.17591182 |
| 103 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.14482358 |
| 104 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.14384333 |
| 105 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.13810002 |
| 106 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.12984896 |
| 107 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.12731997 |
| 108 | Leishmaniasis_Homo sapiens_hsa05140 | 0.11141547 |
| 109 | Salmonella infection_Homo sapiens_hsa05132 | 0.10522459 |
| 110 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.09780788 |
| 111 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.09047128 |
| 112 | Salivary secretion_Homo sapiens_hsa04970 | 0.08923928 |
| 113 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.08126541 |
| 114 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.07621529 |
| 115 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.06194885 |
| 116 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.05420470 |
| 117 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.05389023 |
| 118 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.02026740 |
| 119 | Cocaine addiction_Homo sapiens_hsa05030 | 0.01990154 |

