CLSPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.53682218
2DNA unwinding involved in DNA replication (GO:0006268)5.52237789
3mitotic chromosome condensation (GO:0007076)5.08694797
4DNA strand elongation involved in DNA replication (GO:0006271)4.97726780
5kinetochore organization (GO:0051383)4.96405513
6protein localization to chromosome, centromeric region (GO:0071459)4.90772531
7DNA replication initiation (GO:0006270)4.79888938
8mitotic sister chromatid segregation (GO:0000070)4.77309620
9nuclear pore complex assembly (GO:0051292)4.74879706
10DNA strand elongation (GO:0022616)4.73719014
11nuclear pore organization (GO:0006999)4.72637113
12sister chromatid segregation (GO:0000819)4.70008863
13mitotic metaphase plate congression (GO:0007080)4.68815890
14telomere maintenance via semi-conservative replication (GO:0032201)4.63914421
15DNA replication-dependent nucleosome assembly (GO:0006335)4.45985579
16DNA replication-dependent nucleosome organization (GO:0034723)4.45985579
17mitotic recombination (GO:0006312)4.42035307
18mitotic sister chromatid cohesion (GO:0007064)4.37939949
19telomere maintenance via recombination (GO:0000722)4.35958800
20chromatin remodeling at centromere (GO:0031055)4.31725542
21CENP-A containing nucleosome assembly (GO:0034080)4.31174494
22metaphase plate congression (GO:0051310)4.27540136
23attachment of spindle microtubules to kinetochore (GO:0008608)4.25040470
24mitotic nuclear envelope disassembly (GO:0007077)4.24057140
25kinetochore assembly (GO:0051382)4.19873198
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.18410914
27DNA replication-independent nucleosome assembly (GO:0006336)4.13109323
28DNA replication-independent nucleosome organization (GO:0034724)4.13109323
29* DNA replication checkpoint (GO:0000076)4.09840358
30meiotic chromosome segregation (GO:0045132)4.09717095
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03933874
32establishment of chromosome localization (GO:0051303)3.94110264
33membrane disassembly (GO:0030397)3.93568168
34nuclear envelope disassembly (GO:0051081)3.93568168
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.92976898
36establishment of integrated proviral latency (GO:0075713)3.92022348
37maturation of SSU-rRNA (GO:0030490)3.89527343
38positive regulation of chromosome segregation (GO:0051984)3.86228347
39replication fork processing (GO:0031297)3.85572895
40chromatin assembly or disassembly (GO:0006333)3.82330978
41regulation of spindle organization (GO:0090224)3.80648258
42DNA duplex unwinding (GO:0032508)3.78266923
43DNA geometric change (GO:0032392)3.77974680
44telomere maintenance via telomere lengthening (GO:0010833)3.74971476
45histone exchange (GO:0043486)3.71462167
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.71434040
47pore complex assembly (GO:0046931)3.68825219
48protein localization to chromosome (GO:0034502)3.65196070
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.63624689
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.63624689
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.63624689
52regulation of sister chromatid cohesion (GO:0007063)3.57618559
53ribosomal small subunit biogenesis (GO:0042274)3.56645622
54folic acid-containing compound biosynthetic process (GO:0009396)3.55637896
55chromosome segregation (GO:0007059)3.54928218
56regulation of DNA endoreduplication (GO:0032875)3.51089654
57DNA ligation (GO:0006266)3.50706632
58DNA topological change (GO:0006265)3.49726223
59regulation of histone H3-K9 methylation (GO:0051570)3.49470583
60regulation of chromosome segregation (GO:0051983)3.49096384
61chromosome condensation (GO:0030261)3.45060894
62translesion synthesis (GO:0019985)3.44355693
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41980560
64regulation of centrosome cycle (GO:0046605)3.41955501
65regulation of centriole replication (GO:0046599)3.41505127
66ATP-dependent chromatin remodeling (GO:0043044)3.40446686
67spindle checkpoint (GO:0031577)3.39820515
68DNA double-strand break processing (GO:0000729)3.39450254
69DNA conformation change (GO:0071103)3.39118561
70regulation of mitotic spindle organization (GO:0060236)3.37805000
71IMP biosynthetic process (GO:0006188)3.37480504
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35312204
73chromatin assembly (GO:0031497)3.32674813
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30074307
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28302647
76protein K6-linked ubiquitination (GO:0085020)3.27676079
77purine nucleobase biosynthetic process (GO:0009113)3.26232166
78negative regulation of chromosome segregation (GO:0051985)3.24610367
79spindle assembly checkpoint (GO:0071173)3.24605471
80ribosomal small subunit assembly (GO:0000028)3.21718332
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21706113
82heterochromatin organization (GO:0070828)3.20988481
83resolution of meiotic recombination intermediates (GO:0000712)3.20291154
84nucleobase biosynthetic process (GO:0046112)3.19709758
85DNA packaging (GO:0006323)3.19338587
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.18759198
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18759198
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18759198
89negative regulation of sister chromatid segregation (GO:0033046)3.18759198
90DNA strand renaturation (GO:0000733)3.17553807
91telomere maintenance (GO:0000723)3.17244634
92centriole replication (GO:0007099)3.17177466
93double-strand break repair via nonhomologous end joining (GO:0006303)3.16475626
94non-recombinational repair (GO:0000726)3.16475626
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16098511
96regulation of mitotic spindle checkpoint (GO:1903504)3.16098511
97telomere organization (GO:0032200)3.15119705
98regulation of mitotic sister chromatid separation (GO:0010965)3.14755232
99regulation of mitotic sister chromatid segregation (GO:0033047)3.14755232
100regulation of sister chromatid segregation (GO:0033045)3.14755232
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14021521
102establishment of protein localization to mitochondrial membrane (GO:0090151)3.13498850
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12467596
104mitotic spindle assembly checkpoint (GO:0007094)3.12173696
105formation of translation preinitiation complex (GO:0001731)3.11186936
106negative regulation of histone methylation (GO:0031061)3.10580409
107transcription-coupled nucleotide-excision repair (GO:0006283)3.09911455
108postreplication repair (GO:0006301)3.09132440
109recombinational repair (GO:0000725)3.08918059
110regulation of RNA export from nucleus (GO:0046831)3.08704992
111DNA catabolic process, exonucleolytic (GO:0000738)3.08411560
112nuclear envelope organization (GO:0006998)3.08256640
113double-strand break repair via homologous recombination (GO:0000724)3.08210516
114mitotic spindle checkpoint (GO:0071174)3.07563874
115dosage compensation (GO:0007549)3.07457866
116regulation of double-strand break repair via homologous recombination (GO:0010569)3.04502747
117DNA synthesis involved in DNA repair (GO:0000731)3.04321986
118proteasome assembly (GO:0043248)3.03207384
119mismatch repair (GO:0006298)3.03131023
120ribosomal large subunit biogenesis (GO:0042273)3.02407286
121* DNA replication (GO:0006260)3.02105164
122spliceosomal snRNP assembly (GO:0000387)3.00899189
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.99875680
124microtubule depolymerization (GO:0007019)2.99847292
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.98528644
126mitotic cell cycle (GO:0000278)2.98418469
127translational termination (GO:0006415)2.98019380
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97451866
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.95957380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.31807316
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.75516527
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.96911824
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.49227737
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07180494
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.77090856
7AR_21909140_ChIP-Seq_LNCAP_Human2.66903262
8* E2F1_21310950_ChIP-Seq_MCF-7_Human2.56895361
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50593778
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38659113
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27237448
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24088426
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11841256
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11551310
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.10761897
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10197187
17MYC_22102868_ChIP-Seq_BL_Human2.07261294
18E2F7_22180533_ChIP-Seq_HELA_Human11.9050496
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97888386
20* XRN2_22483619_ChIP-Seq_HELA_Human1.95654785
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95442005
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.83209175
23VDR_23849224_ChIP-Seq_CD4+_Human1.75301378
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74085043
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73395547
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71781178
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67739540
28FOXP3_21729870_ChIP-Seq_TREG_Human1.66992252
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.66837416
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.65479285
31CIITA_25753668_ChIP-Seq_RAJI_Human1.62878197
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55609904
33TTF2_22483619_ChIP-Seq_HELA_Human1.54289512
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53865955
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53391064
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52892569
37KDM5A_27292631_Chip-Seq_BREAST_Human1.47821437
38DCP1A_22483619_ChIP-Seq_HELA_Human1.47078579
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46177973
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44782839
41ELK1_19687146_ChIP-ChIP_HELA_Human1.43503384
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43011910
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41945333
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41288101
45GABP_19822575_ChIP-Seq_HepG2_Human1.39481045
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35026446
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.34609227
48VDR_21846776_ChIP-Seq_THP-1_Human1.33710024
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33678840
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30126343
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28962056
52EWS_26573619_Chip-Seq_HEK293_Human1.28632993
53* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25949089
54* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25734060
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24786440
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22394099
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20832755
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20477290
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17646664
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.17027234
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16624243
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13863353
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.12686784
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11723453
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.11049586
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10492764
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09908789
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09654676
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08305365
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06691008
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05831849
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04691468
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04525469
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02461935
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02081764
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01880510
77TFEB_21752829_ChIP-Seq_HELA_Human1.01677268
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.00658430
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99733187
80* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99080958
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97174286
82IRF1_19129219_ChIP-ChIP_H3396_Human0.97060916
83* FUS_26573619_Chip-Seq_HEK293_Human0.94199118
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92902617
85RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92312332
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91934163
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90072469
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.89844110
89MYC_18940864_ChIP-ChIP_HL60_Human0.89422132
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87479567
91SPI1_23547873_ChIP-Seq_NB4_Human0.87447557
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.86410172
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86371221
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86273468
95UTX_26944678_Chip-Seq_JUKART_Human0.86238264
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85558752
97ZNF274_21170338_ChIP-Seq_K562_Hela0.83767255
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83306785
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82873373
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82562421
101MYB_26560356_Chip-Seq_TH1_Human0.80625717
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79606504
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77701036
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.77130517
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77052908
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76833133
107MYB_26560356_Chip-Seq_TH2_Human0.76056441
108* MAF_26560356_Chip-Seq_TH1_Human0.75595305
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75163824
110TCF7_22412390_ChIP-Seq_EML_Mouse0.74340289
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72487022
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72133202
113* CHD1_26751641_Chip-Seq_LNCaP_Human0.71206157
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70344858
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.64315126
116VDR_22108803_ChIP-Seq_LS180_Human0.62704612
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.62629000
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.58233179
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.56995172
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.55532404
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.52021128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02064599
2MP0010094_abnormal_chromosome_stability5.00377223
3MP0003111_abnormal_nucleus_morphology4.63134825
4MP0008057_abnormal_DNA_replication4.13185267
5MP0003077_abnormal_cell_cycle4.03328540
6MP0004957_abnormal_blastocyst_morpholog3.90435982
7MP0008058_abnormal_DNA_repair2.88033337
8MP0002396_abnormal_hematopoietic_system2.66126897
9MP0008007_abnormal_cellular_replicative2.64787722
10MP0008877_abnormal_DNA_methylation2.62315052
11MP0003123_paternal_imprinting2.51925243
12MP0009697_abnormal_copulation2.48864195
13MP0010307_abnormal_tumor_latency2.45768891
14MP0008932_abnormal_embryonic_tissue2.44377089
15MP0001730_embryonic_growth_arrest2.38455851
16MP0009379_abnormal_foot_pigmentation2.37843123
17MP0000350_abnormal_cell_proliferation2.36295563
18MP0010352_gastrointestinal_tract_polyps2.25397513
19MP0005076_abnormal_cell_differentiation1.97137360
20MP0003121_genomic_imprinting1.96571686
21MP0004808_abnormal_hematopoietic_stem1.86952365
22MP0001672_abnormal_embryogenesis/_devel1.84498871
23MP0005380_embryogenesis_phenotype1.84498871
24MP0001697_abnormal_embryo_size1.75926317
25MP0000490_abnormal_crypts_of1.74288440
26MP0002938_white_spotting1.68682967
27MP0003984_embryonic_growth_retardation1.67469382
28MP0002088_abnormal_embryonic_growth/wei1.63730275
29MP0003786_premature_aging1.61387228
30MP0002085_abnormal_embryonic_tissue1.59794177
31MP0004197_abnormal_fetal_growth/weight/1.57180668
32MP0002080_prenatal_lethality1.54239123
33MP0002084_abnormal_developmental_patter1.53661931
34MP0002086_abnormal_extraembryonic_tissu1.52514487
35MP0002019_abnormal_tumor_incidence1.46950074
36MP0000313_abnormal_cell_death1.45902497
37MP0003941_abnormal_skin_development1.40607567
38MP0003567_abnormal_fetal_cardiomyocyte1.35722855
39MP0000703_abnormal_thymus_morphology1.32841706
40MP0008789_abnormal_olfactory_epithelium1.32684497
41MP0003705_abnormal_hypodermis_morpholog1.32126251
42MP0002160_abnormal_reproductive_system1.29834565
43MP0006072_abnormal_retinal_apoptosis1.23985735
44MP0005397_hematopoietic_system_phenotyp1.22721298
45MP0001545_abnormal_hematopoietic_system1.22721298
46MP0002398_abnormal_bone_marrow1.21591590
47MP0003890_abnormal_embryonic-extraembry1.21204354
48MP0000569_abnormal_digit_pigmentation1.20970347
49MP0003787_abnormal_imprinting1.18987884
50MP0000049_abnormal_middle_ear1.18065660
51MP0003763_abnormal_thymus_physiology1.16762055
52MP0009278_abnormal_bone_marrow1.16222876
53MP0002210_abnormal_sex_determination1.15327353
54MP0006035_abnormal_mitochondrial_morpho1.13083913
55MP0003136_yellow_coat_color1.11526202
56MP0002234_abnormal_pharynx_morphology1.10149659
57MP0010030_abnormal_orbit_morphology1.09586864
58MP0002722_abnormal_immune_system1.07630622
59MP0002102_abnormal_ear_morphology1.06454977
60MP0001293_anophthalmia1.01475836
61MP0001529_abnormal_vocalization1.01141436
62MP0009333_abnormal_splenocyte_physiolog1.01046923
63MP0009672_abnormal_birth_weight1.00137533
64MP0000689_abnormal_spleen_morphology0.99966517
65MP0002233_abnormal_nose_morphology0.99030208
66MP0005499_abnormal_olfactory_system0.98860910
67MP0005394_taste/olfaction_phenotype0.98860910
68MP0003315_abnormal_perineum_morphology0.98098737
69MP0000537_abnormal_urethra_morphology0.97994782
70MP0003806_abnormal_nucleotide_metabolis0.97856412
71MP0001145_abnormal_male_reproductive0.97192651
72MP0000631_abnormal_neuroendocrine_gland0.95423508
73MP0003937_abnormal_limbs/digits/tail_de0.94212580
74MP0006054_spinal_hemorrhage0.92409141
75MP0009053_abnormal_anal_canal0.91834101
76MP0009703_decreased_birth_body0.91662729
77MP0003718_maternal_effect0.91318592
78MP0001915_intracranial_hemorrhage0.90499306
79MP0001929_abnormal_gametogenesis0.89905314
80MP0003861_abnormal_nervous_system0.87681752
81MP0003566_abnormal_cell_adhesion0.86633199
82MP0000358_abnormal_cell_content/0.86361659
83MP0002429_abnormal_blood_cell0.86062816
84MP0003755_abnormal_palate_morphology0.85375841
85MP0000653_abnormal_sex_gland0.85159028
86MP0006036_abnormal_mitochondrial_physio0.84066551
87MP0001188_hyperpigmentation0.83016251
88MP0001485_abnormal_pinna_reflex0.82372878
89MP0005023_abnormal_wound_healing0.81827466
90MP0005389_reproductive_system_phenotype0.81444779
91MP0005621_abnormal_cell_physiology0.81349176
92MP0001119_abnormal_female_reproductive0.80929455
93MP0003698_abnormal_male_reproductive0.80889127
94MP0004147_increased_porphyrin_level0.79865928
95MP0005384_cellular_phenotype0.79293337
96MP0003938_abnormal_ear_development0.78258979
97MP0005391_vision/eye_phenotype0.77983053
98MP0003186_abnormal_redox_activity0.77922305
99MP0000428_abnormal_craniofacial_morphol0.77651991
100MP0008995_early_reproductive_senescence0.76117969
101MP0000733_abnormal_muscle_development0.76069620
102MP0000716_abnormal_immune_system0.74326506
103MP0001849_ear_inflammation0.74163677
104MP0002092_abnormal_eye_morphology0.73363027
105MP0000858_altered_metastatic_potential0.73064007
106MP0002111_abnormal_tail_morphology0.72546291
107MP0002877_abnormal_melanocyte_morpholog0.71133372
108MP0001346_abnormal_lacrimal_gland0.70243315
109MP0000432_abnormal_head_morphology0.68571035
110MP0002161_abnormal_fertility/fecundity0.68385046
111MP0000372_irregular_coat_pigmentation0.66967999
112MP0004264_abnormal_extraembryonic_tissu0.66951262
113MP0005174_abnormal_tail_pigmentation0.66723975
114MP0002751_abnormal_autonomic_nervous0.66649482
115MP0002095_abnormal_skin_pigmentation0.65095251
116MP0002925_abnormal_cardiovascular_devel0.64885382
117MP0001800_abnormal_humoral_immune0.64579844
118MP0002006_tumorigenesis0.64313046
119MP0003448_altered_tumor_morphology0.63918331
120MP0002697_abnormal_eye_size0.63364665
121MP0000647_abnormal_sebaceous_gland0.63100075
122MP0003936_abnormal_reproductive_system0.63075504
123MP0005408_hypopigmentation0.62542519
124MP0001286_abnormal_eye_development0.62398679
125MP0003935_abnormal_craniofacial_develop0.62248392
126MP0000477_abnormal_intestine_morphology0.61582976
127MP0001919_abnormal_reproductive_system0.61544723
128MP0004133_heterotaxia0.60061969
129MP0003115_abnormal_respiratory_system0.59474365
130MP0003119_abnormal_digestive_system0.59383254
131MP0002075_abnormal_coat/hair_pigmentati0.58697351
132MP0002166_altered_tumor_susceptibility0.57817853
133MP0003385_abnormal_body_wall0.57259451
134MP0003300_gastrointestinal_ulcer0.57227918
135MP0002420_abnormal_adaptive_immunity0.56680508
136MP0008770_decreased_survivor_rate0.56515842
137MP0006292_abnormal_olfactory_placode0.55332209
138MP0001819_abnormal_immune_cell0.55259330
139MP0002452_abnormal_antigen_presenting0.54396197
140MP0003699_abnormal_female_reproductive0.52835340
141MP0003221_abnormal_cardiomyocyte_apopto0.52609103

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.01159494
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.67269461
3Birth length less than 3rd percentile (HP:0003561)4.15448097
4Abnormality of chromosome stability (HP:0003220)3.80786088
5Volvulus (HP:0002580)3.55328377
6Reticulocytopenia (HP:0001896)3.41159907
7Meckel diverticulum (HP:0002245)3.31678353
8Ectopic kidney (HP:0000086)3.18766498
9Patellar aplasia (HP:0006443)3.17719425
10Abnormality of the ileum (HP:0001549)3.16270461
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.14416658
12Abnormality of the preputium (HP:0100587)3.13421530
13Medulloblastoma (HP:0002885)3.05725208
14Increased nuchal translucency (HP:0010880)3.02294876
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01379709
16Acute necrotizing encephalopathy (HP:0006965)3.01094910
17Selective tooth agenesis (HP:0001592)2.97675760
18Breast hypoplasia (HP:0003187)2.95014840
19Impulsivity (HP:0100710)2.94618755
20Aplasia/Hypoplasia of the patella (HP:0006498)2.94584521
21Ependymoma (HP:0002888)2.86290317
22Myelodysplasia (HP:0002863)2.77961997
23Abnormality of the fingertips (HP:0001211)2.77025095
24Short 4th metacarpal (HP:0010044)2.75865810
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75865810
26Small intestinal stenosis (HP:0012848)2.75515415
27Duodenal stenosis (HP:0100867)2.75515415
28Abnormal mitochondria in muscle tissue (HP:0008316)2.71455434
29Acute encephalopathy (HP:0006846)2.69857999
30Proximal placement of thumb (HP:0009623)2.68588255
31Deviation of the thumb (HP:0009603)2.64722185
32Colon cancer (HP:0003003)2.63892506
33Rhabdomyosarcoma (HP:0002859)2.63205031
34Macrocytic anemia (HP:0001972)2.61842349
35High pitched voice (HP:0001620)2.53395330
36Abnormality of the carotid arteries (HP:0005344)2.51837221
37Prominent nose (HP:0000448)2.49737160
38Facial hemangioma (HP:0000329)2.41095631
39Absent radius (HP:0003974)2.36155639
40Cafe-au-lait spot (HP:0000957)2.36088762
41Absent thumb (HP:0009777)2.34791949
42Abnormal number of incisors (HP:0011064)2.34556228
43Abnormality of cochlea (HP:0000375)2.33635790
44Progressive macrocephaly (HP:0004481)2.33602600
45Abnormality of the labia minora (HP:0012880)2.32734577
46Agnosia (HP:0010524)2.29918984
47Duplicated collecting system (HP:0000081)2.29901849
48Sloping forehead (HP:0000340)2.29237033
49Long eyelashes (HP:0000527)2.28705059
50Abnormality of the anterior horn cell (HP:0006802)2.27429157
51Degeneration of anterior horn cells (HP:0002398)2.27429157
52Basal cell carcinoma (HP:0002671)2.25020319
53Atresia of the external auditory canal (HP:0000413)2.24089099
54Abnormality of the duodenum (HP:0002246)2.23965898
55Increased hepatocellular lipid droplets (HP:0006565)2.22824296
56Mitochondrial inheritance (HP:0001427)2.21404311
57Oral leukoplakia (HP:0002745)2.18681801
58Bone marrow hypocellularity (HP:0005528)2.18458755
59Increased CSF lactate (HP:0002490)2.17860858
60Aplasia involving forearm bones (HP:0009822)2.17458537
61Absent forearm bone (HP:0003953)2.17458537
62Duplication of thumb phalanx (HP:0009942)2.17071155
63Short thumb (HP:0009778)2.14790414
64Carpal bone hypoplasia (HP:0001498)2.14742007
65Abnormality of cells of the erythroid lineage (HP:0012130)2.14490348
66Clubbing of toes (HP:0100760)2.10355965
67Abnormal lung lobation (HP:0002101)2.09585876
68Nephroblastoma (Wilms tumor) (HP:0002667)2.09420325
69Tracheoesophageal fistula (HP:0002575)2.08740612
70Astrocytoma (HP:0009592)2.07925080
71Abnormality of the astrocytes (HP:0100707)2.07925080
72Squamous cell carcinoma (HP:0002860)2.07288776
73Abnormal number of erythroid precursors (HP:0012131)2.07205564
74Septo-optic dysplasia (HP:0100842)2.06758452
75Neoplasm of striated muscle (HP:0009728)2.04448542
7611 pairs of ribs (HP:0000878)2.03758813
77Deep philtrum (HP:0002002)2.02075062
78Cerebral edema (HP:0002181)2.00185859
79Abnormality of the renal collecting system (HP:0004742)1.99267426
80Lipid accumulation in hepatocytes (HP:0006561)1.98922761
81Neoplasm of the pancreas (HP:0002894)1.98448579
82Cortical dysplasia (HP:0002539)1.98020340
83Hypoplasia of the pons (HP:0012110)1.96739034
84Pendular nystagmus (HP:0012043)1.95801971
85Acute myeloid leukemia (HP:0004808)1.95703502
86Pancytopenia (HP:0001876)1.94219246
87Premature graying of hair (HP:0002216)1.92858081
88Embryonal renal neoplasm (HP:0011794)1.92688799
89Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92558334
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.92309339
91Glioma (HP:0009733)1.91494117
92Abnormality of the pons (HP:0007361)1.86226911
93Overlapping toe (HP:0001845)1.86119947
94Sandal gap (HP:0001852)1.86047554
95Abnormality of chromosome segregation (HP:0002916)1.85942948
96Aplastic anemia (HP:0001915)1.85609176
97Acute lymphatic leukemia (HP:0006721)1.84862738
98Microtia (HP:0008551)1.84740017
99Neoplasm of the oral cavity (HP:0100649)1.84600722
100Abnormality of DNA repair (HP:0003254)1.83822697
101Abnormality of the 4th metacarpal (HP:0010012)1.83491647
102Triphalangeal thumb (HP:0001199)1.82319852
103Facial cleft (HP:0002006)1.81702250
104Lymphoma (HP:0002665)1.81277034
105Horseshoe kidney (HP:0000085)1.81199360
106Slender long bone (HP:0003100)1.80574941
107Morphological abnormality of the inner ear (HP:0011390)1.78974474
108Multiple enchondromatosis (HP:0005701)1.77813822
109Hypoplastic pelvis (HP:0008839)1.77561128
110Supernumerary spleens (HP:0009799)1.77403522
111Hyperacusis (HP:0010780)1.76084287
112Pallor (HP:0000980)1.75822446
113Megaloblastic anemia (HP:0001889)1.75749238
114Cleft eyelid (HP:0000625)1.74293273
115Abnormality of the septum pellucidum (HP:0007375)1.73602276
116Absent septum pellucidum (HP:0001331)1.72373704
117IgM deficiency (HP:0002850)1.72344353
118Arteriovenous malformation (HP:0100026)1.72017334
119Broad palm (HP:0001169)1.70033509
120Stenosis of the external auditory canal (HP:0000402)1.69964933
121Renal duplication (HP:0000075)1.69753971
122Choanal atresia (HP:0000453)1.69161890
123Missing ribs (HP:0000921)1.69120033
124Small hand (HP:0200055)1.69017887
125Abnormality of reticulocytes (HP:0004312)1.68720990
126Abnormality of the calcaneus (HP:0008364)1.68466228
127Cutis marmorata (HP:0000965)1.68295662
128Cellular immunodeficiency (HP:0005374)1.66986952
129Neoplasm of the colon (HP:0100273)1.66462790
130Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65811477
131Blepharitis (HP:0000498)1.65698506
132Hepatocellular necrosis (HP:0001404)1.65421541
133Bilateral microphthalmos (HP:0007633)1.65257490
134Leukodystrophy (HP:0002415)1.62967774
135Esophageal atresia (HP:0002032)1.62529376
136Preaxial hand polydactyly (HP:0001177)1.61697014
137Rectal fistula (HP:0100590)1.59370369
138Rectovaginal fistula (HP:0000143)1.59370369
139Increased serum lactate (HP:0002151)1.58655531
140Microvesicular hepatic steatosis (HP:0001414)1.58548239
141Sclerocornea (HP:0000647)1.58487931
142Short middle phalanx of the 5th finger (HP:0004220)1.58252870
143Oligodactyly (hands) (HP:0001180)1.57201908
144Hypoplasia of the radius (HP:0002984)1.56152571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* CDC74.63859999
2NEK23.64433786
3WEE13.60250599
4CDK123.35131040
5VRK23.26656951
6BUB13.24405499
7TTK2.66411556
8SRPK12.51094338
9PLK42.28683919
10TAF12.28652008
11EIF2AK12.26261689
12EEF2K2.22190704
13BRSK22.13542381
14NEK12.03349876
15NUAK12.03270587
16* PLK12.03193588
17ATR2.00723657
18AURKB1.99788551
19STK101.89503419
20MAP3K101.88456358
21MKNK11.88427325
22CDK41.87395397
23ACVR1B1.84087928
24CHEK21.81833812
25STK41.73042981
26CDK71.72229545
27TLK11.70444948
28PLK31.62685693
29STK161.56879615
30RPS6KB21.54699540
31BRSK11.51463472
32MAP3K81.51155370
33* CHEK11.49526080
34PASK1.49052612
35TSSK61.45817770
36STK31.44912511
37MKNK21.43212564
38BRD41.43211025
39RPS6KA41.41406834
40VRK11.38269347
41CDK61.33231774
42BMPR1B1.33224568
43MST41.28247642
44NME11.23934593
45SCYL21.23670808
46ATM1.22102933
47TNIK1.19780140
48TESK21.13227516
49AURKA1.09144582
50CDK21.09045543
51PKN21.07034257
52MELK1.06988490
53DYRK31.06143050
54TRIM281.04541719
55EIF2AK31.04242752
56ZAK1.03917420
57LATS11.01617655
58MAP4K11.01413065
59PIM11.00330047
60CCNB10.95816863
61ALK0.95295634
62PLK20.94101166
63CLK10.93434015
64NME20.92054699
65CDK10.87345111
66LRRK20.82262504
67WNK30.81161146
68CDK80.80859500
69TGFBR10.79747177
70PAK40.77535206
71DYRK20.77219106
72CDK90.74862688
73BRAF0.72153128
74MTOR0.70859602
75SMG10.70418861
76CDK30.68300888
77CAMK1G0.60288080
78CSNK1G10.55770584
79CSNK2A20.55088637
80RPS6KA50.53065640
81TRIB30.53011435
82PRKDC0.52344463
83CSNK2A10.50308914
84EIF2AK20.49773156
85GRK60.49202559
86TTN0.49129072
87MAPK140.46920904
88MAPKAPK50.46716691
89CSNK1G30.44583452
90PAK10.44455246
91CSF1R0.43744288
92CSNK1D0.42477978
93STK38L0.41809366
94MAP2K30.40748059
95AKT20.39595189
96ERBB40.38370607
97TRPM70.36871580
98CSNK1E0.36867942
99PAK20.36669343
100AKT10.35674059
101LATS20.35641205
102BTK0.35530485
103MARK30.35528083
104CAMK1D0.35148919
105STK240.35125236
106GRK10.33949466
107MAP3K40.33928162
108FLT30.33834030
109WNK40.33581406
110PDK20.31903571
111CSNK1A1L0.30989042
112CSNK1G20.30523515
113GSK3B0.29755048
114JAK30.28805402
115MAP4K20.28024508
116INSRR0.27854506
117MAPK10.27102857
118CDK150.26062491
119MAPK110.26003647
120CDK180.25167525
121EPHA20.22611588
122FGFR10.22295247
123CHUK0.20962929
124PBK0.20808742
125TEC0.19953530
126PRKCI0.19564602
127MAPKAPK20.19523257
128PNCK0.19134128
129NEK90.18616719
130CDK11A0.17944666
131PTK60.17638447

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.32213247
2Mismatch repair_Homo sapiens_hsa034304.38825121
3Cell cycle_Homo sapiens_hsa041103.40021300
4Homologous recombination_Homo sapiens_hsa034403.29425670
5Spliceosome_Homo sapiens_hsa030403.09716781
6Base excision repair_Homo sapiens_hsa034103.09150387
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04236069
8RNA transport_Homo sapiens_hsa030132.99271921
9Nucleotide excision repair_Homo sapiens_hsa034202.73910316
10Fanconi anemia pathway_Homo sapiens_hsa034602.72462507
11One carbon pool by folate_Homo sapiens_hsa006702.69037776
12Non-homologous end-joining_Homo sapiens_hsa034502.48275681
13RNA polymerase_Homo sapiens_hsa030202.10311334
14mRNA surveillance pathway_Homo sapiens_hsa030152.03902437
15Ribosome_Homo sapiens_hsa030102.02184928
16Oxidative phosphorylation_Homo sapiens_hsa001901.96684667
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94187167
18Systemic lupus erythematosus_Homo sapiens_hsa053221.92866710
19Pyrimidine metabolism_Homo sapiens_hsa002401.91270011
20RNA degradation_Homo sapiens_hsa030181.87754830
21Parkinsons disease_Homo sapiens_hsa050121.82267307
22Protein export_Homo sapiens_hsa030601.82064062
23p53 signaling pathway_Homo sapiens_hsa041151.80050867
24Basal transcription factors_Homo sapiens_hsa030221.73026023
25Huntingtons disease_Homo sapiens_hsa050161.59918609
26Proteasome_Homo sapiens_hsa030501.52876303
27Viral carcinogenesis_Homo sapiens_hsa052031.38200015
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23530427
29Oocyte meiosis_Homo sapiens_hsa041141.21449407
30MicroRNAs in cancer_Homo sapiens_hsa052061.18745087
31Epstein-Barr virus infection_Homo sapiens_hsa051691.17056737
32Herpes simplex infection_Homo sapiens_hsa051681.16979427
33Folate biosynthesis_Homo sapiens_hsa007901.15120259
34Antigen processing and presentation_Homo sapiens_hsa046121.10267080
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09305412
36Alzheimers disease_Homo sapiens_hsa050101.09264764
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08814169
38HTLV-I infection_Homo sapiens_hsa051661.06661923
39Pyruvate metabolism_Homo sapiens_hsa006201.05739352
40Small cell lung cancer_Homo sapiens_hsa052221.03979464
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03037884
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94158979
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93113806
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91416561
45Purine metabolism_Homo sapiens_hsa002300.90493147
46Chronic myeloid leukemia_Homo sapiens_hsa052200.89144748
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88359720
48Primary immunodeficiency_Homo sapiens_hsa053400.88261316
49Alcoholism_Homo sapiens_hsa050340.86036470
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83948181
51Colorectal cancer_Homo sapiens_hsa052100.74946096
52Thyroid cancer_Homo sapiens_hsa052160.74734114
53Lysine degradation_Homo sapiens_hsa003100.72951249
54Hepatitis B_Homo sapiens_hsa051610.72464665
55Steroid biosynthesis_Homo sapiens_hsa001000.71315712
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68671840
57Cardiac muscle contraction_Homo sapiens_hsa042600.68202181
58Apoptosis_Homo sapiens_hsa042100.66975330
59Pancreatic cancer_Homo sapiens_hsa052120.66704599
60Propanoate metabolism_Homo sapiens_hsa006400.66417754
61Non-small cell lung cancer_Homo sapiens_hsa052230.64335862
62Glutathione metabolism_Homo sapiens_hsa004800.62866042
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61845863
64Measles_Homo sapiens_hsa051620.60190733
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.59876215
66Viral myocarditis_Homo sapiens_hsa054160.59718694
67TGF-beta signaling pathway_Homo sapiens_hsa043500.58283098
68Selenocompound metabolism_Homo sapiens_hsa004500.57693104
69Sulfur relay system_Homo sapiens_hsa041220.57655528
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57368258
71Prostate cancer_Homo sapiens_hsa052150.57077015
72Adherens junction_Homo sapiens_hsa045200.55078828
73Notch signaling pathway_Homo sapiens_hsa043300.54515954
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54142019
75Hippo signaling pathway_Homo sapiens_hsa043900.52903847
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52699790
77Bladder cancer_Homo sapiens_hsa052190.51760639
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51216570
79Basal cell carcinoma_Homo sapiens_hsa052170.49345487
80Fatty acid elongation_Homo sapiens_hsa000620.48192686
81Metabolic pathways_Homo sapiens_hsa011000.46857832
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46191602
83mTOR signaling pathway_Homo sapiens_hsa041500.45955174
84Legionellosis_Homo sapiens_hsa051340.45847524
85B cell receptor signaling pathway_Homo sapiens_hsa046620.45694449
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45584490
87Pentose phosphate pathway_Homo sapiens_hsa000300.45043662
88Hematopoietic cell lineage_Homo sapiens_hsa046400.44952450
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44892022
90Influenza A_Homo sapiens_hsa051640.44885382
91Pathways in cancer_Homo sapiens_hsa052000.44770388
92Shigellosis_Homo sapiens_hsa051310.44626472
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43364939
94Carbon metabolism_Homo sapiens_hsa012000.43327222
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39301838
96Acute myeloid leukemia_Homo sapiens_hsa052210.39219231
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37664840
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36502996
99FoxO signaling pathway_Homo sapiens_hsa040680.35338344
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.34959086
101Proteoglycans in cancer_Homo sapiens_hsa052050.34915605
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33677888
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.33583500
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32977423
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31880917
106Endometrial cancer_Homo sapiens_hsa052130.31871335
107HIF-1 signaling pathway_Homo sapiens_hsa040660.31654307
108T cell receptor signaling pathway_Homo sapiens_hsa046600.31002723
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.30941086
110Phototransduction_Homo sapiens_hsa047440.30859376
111Biosynthesis of amino acids_Homo sapiens_hsa012300.30550694
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.30023750
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.29468312
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.29072908
115Leishmaniasis_Homo sapiens_hsa051400.28006678
116N-Glycan biosynthesis_Homo sapiens_hsa005100.27202469
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26828722
118Melanoma_Homo sapiens_hsa052180.26231005
119Vitamin B6 metabolism_Homo sapiens_hsa007500.25686436
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24810733
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24319511
122Wnt signaling pathway_Homo sapiens_hsa043100.22345847
123Toxoplasmosis_Homo sapiens_hsa051450.22132884
124Olfactory transduction_Homo sapiens_hsa047400.21538767
125Platelet activation_Homo sapiens_hsa046110.21457957
126Glioma_Homo sapiens_hsa052140.21399489
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.21043657
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20889337
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20446758
130Hedgehog signaling pathway_Homo sapiens_hsa043400.19553743
131Butanoate metabolism_Homo sapiens_hsa006500.19195552
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19167258
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17308508
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15461246
135Nitrogen metabolism_Homo sapiens_hsa009100.14789729
136Vitamin digestion and absorption_Homo sapiens_hsa049770.14435832
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10463141
138Arginine and proline metabolism_Homo sapiens_hsa003300.07416685
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05460820
140Peroxisome_Homo sapiens_hsa041460.04848671
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.04703305
142Caffeine metabolism_Homo sapiens_hsa002320.04602555
143Tryptophan metabolism_Homo sapiens_hsa003800.03910951
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.03134057

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