CLSTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.46134875
2synaptic vesicle maturation (GO:0016188)6.43655652
3locomotory exploration behavior (GO:0035641)5.94795240
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.66990771
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60391435
6glutamate secretion (GO:0014047)5.47675320
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.45132914
8synaptic vesicle exocytosis (GO:0016079)5.33215744
9vocalization behavior (GO:0071625)5.31668107
10regulation of synaptic vesicle exocytosis (GO:2000300)5.14344113
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04016418
12cytoskeletal anchoring at plasma membrane (GO:0007016)4.76434775
13layer formation in cerebral cortex (GO:0021819)4.73096374
14regulation of glutamate receptor signaling pathway (GO:1900449)4.71302407
15cerebellar granule cell differentiation (GO:0021707)4.69090027
16protein localization to synapse (GO:0035418)4.60323732
17regulation of synaptic vesicle transport (GO:1902803)4.53034536
18exploration behavior (GO:0035640)4.46688524
19neurotransmitter secretion (GO:0007269)4.44762610
20regulation of neuronal synaptic plasticity (GO:0048168)4.40913443
21amino acid import (GO:0043090)4.39234618
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37223002
23neuronal action potential propagation (GO:0019227)4.31690878
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.22732224
25cellular potassium ion homeostasis (GO:0030007)4.21471398
26dendritic spine morphogenesis (GO:0060997)4.13725371
27sodium ion export (GO:0071436)4.13058765
28regulation of synapse structural plasticity (GO:0051823)4.09588700
29neuron cell-cell adhesion (GO:0007158)4.09177997
30proline transport (GO:0015824)3.99635027
31synaptic transmission, glutamatergic (GO:0035249)3.90032136
32neurotransmitter-gated ion channel clustering (GO:0072578)3.81866872
33gamma-aminobutyric acid transport (GO:0015812)3.79872753
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76413963
35glutamate receptor signaling pathway (GO:0007215)3.73665743
36activation of protein kinase A activity (GO:0034199)3.73589260
37long-term memory (GO:0007616)3.69325446
38positive regulation of membrane potential (GO:0045838)3.68724372
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64057158
40neuron-neuron synaptic transmission (GO:0007270)3.63934334
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60690784
42adenine nucleotide transport (GO:0051503)3.57323953
43neuromuscular process controlling balance (GO:0050885)3.56681760
44neurotransmitter transport (GO:0006836)3.56131786
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53771064
46hemidesmosome assembly (GO:0031581)3.52554480
47positive regulation of synapse maturation (GO:0090129)3.51397384
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.51066456
49regulation of synaptic plasticity (GO:0048167)3.48015739
50regulation of postsynaptic membrane potential (GO:0060078)3.46427377
51regulation of neurotransmitter secretion (GO:0046928)3.45244413
52regulation of dendritic spine morphogenesis (GO:0061001)3.44834936
53synaptic vesicle endocytosis (GO:0048488)3.39649220
54cerebellar Purkinje cell differentiation (GO:0021702)3.38870164
55neuron recognition (GO:0008038)3.36357527
56cell communication by electrical coupling (GO:0010644)3.36017300
57glycine transport (GO:0015816)3.30702249
58regulation of synapse maturation (GO:0090128)3.30075548
59dendrite morphogenesis (GO:0048813)3.26741075
60long-term synaptic potentiation (GO:0060291)3.24418637
61regulation of neurotransmitter levels (GO:0001505)3.23990800
62positive regulation of neurotransmitter secretion (GO:0001956)3.23922856
63auditory behavior (GO:0031223)3.23540659
64positive regulation of neurotransmitter transport (GO:0051590)3.22513314
65axonal fasciculation (GO:0007413)3.21808103
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20181076
67negative regulation of dendrite morphogenesis (GO:0050774)3.20054565
68surfactant homeostasis (GO:0043129)3.19301849
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.18338880
70transmission of nerve impulse (GO:0019226)3.16692831
71regulation of neurotransmitter transport (GO:0051588)3.15402626
72establishment of nucleus localization (GO:0040023)3.11606741
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11312125
74apical protein localization (GO:0045176)3.10845920
75response to auditory stimulus (GO:0010996)3.10676419
76membrane hyperpolarization (GO:0060081)3.09955834
77innervation (GO:0060384)3.09275553
78regulation of vesicle fusion (GO:0031338)3.09054392
79postsynaptic membrane organization (GO:0001941)3.08890304
80regulation of ARF protein signal transduction (GO:0032012)3.08838779
81central nervous system myelination (GO:0022010)3.08126860
82axon ensheathment in central nervous system (GO:0032291)3.08126860
83vesicle transport along microtubule (GO:0047496)3.08071380
84neuromuscular process controlling posture (GO:0050884)3.07895569
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07888740
86positive regulation of dendritic spine development (GO:0060999)3.07572732
87regulation of voltage-gated calcium channel activity (GO:1901385)3.06561412
88dendritic spine organization (GO:0097061)3.05241983
89neuron remodeling (GO:0016322)3.04014875
90regulation of synaptic transmission, glutamatergic (GO:0051966)3.03404082
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03162935
92regulation of clathrin-mediated endocytosis (GO:2000369)3.02180636
93cell communication involved in cardiac conduction (GO:0086065)3.01052109
94neuronal ion channel clustering (GO:0045161)2.99797034
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.99410320
96potassium ion import (GO:0010107)2.98748855
97prepulse inhibition (GO:0060134)2.98480351
98membrane depolarization during action potential (GO:0086010)2.96659626
99membrane depolarization (GO:0051899)2.96208440
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94458288
101peptidyl-tyrosine autophosphorylation (GO:0038083)2.92958609
102cell migration in hindbrain (GO:0021535)2.92380313
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.91811820
104mating behavior (GO:0007617)2.90644137
105potassium ion homeostasis (GO:0055075)2.90542673
106neuromuscular process (GO:0050905)2.90420840
107purine nucleotide transport (GO:0015865)2.89400218
108positive regulation of synaptic transmission (GO:0050806)2.89012381
109L-amino acid import (GO:0043092)2.88967650
110cellular sodium ion homeostasis (GO:0006883)2.88162628
111regulation of dendritic spine development (GO:0060998)2.88037145
112chemosensory behavior (GO:0007635)2.87961422
113regulation of synaptic transmission (GO:0050804)2.85916727
114synapse assembly (GO:0007416)2.85272435
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85109033
116cerebellar Purkinje cell layer development (GO:0021680)2.84378550
117social behavior (GO:0035176)2.84244750
118intraspecies interaction between organisms (GO:0051703)2.84244750
119dicarboxylic acid transport (GO:0006835)2.82401462
120acidic amino acid transport (GO:0015800)2.80946726
121dopamine receptor signaling pathway (GO:0007212)2.76802558
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76005368
123chemical homeostasis within a tissue (GO:0048875)2.56474210
124positive regulation of dendrite development (GO:1900006)2.55168400
125negative regulation of type 2 immune response (GO:0002829)2.54877029
126L-glutamate transport (GO:0015813)2.54844815
127cell differentiation in hindbrain (GO:0021533)2.53520503
128adherens junction assembly (GO:0034333)2.52155525
129semaphorin-plexin signaling pathway (GO:0071526)2.50967776
130visual learning (GO:0008542)2.48944851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.53033807
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.60860183
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03284185
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01012063
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96668860
6GBX2_23144817_ChIP-Seq_PC3_Human2.81325293
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78710721
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78710721
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.71647308
10DROSHA_22980978_ChIP-Seq_HELA_Human2.70978777
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66621992
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.60701511
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54389656
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53678534
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50401562
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43217199
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42798292
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41490126
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.40614718
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30053801
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29016573
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.28864332
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.25522461
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.19151342
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15281708
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.14231289
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13754129
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.09794423
29* LXR_22292898_ChIP-Seq_THP-1_Human2.04985180
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02892381
31TRIM28_21343339_ChIP-Seq_HEK293_Human2.02753372
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87382950
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87354409
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.86654742
35AR_21572438_ChIP-Seq_LNCaP_Human1.70416219
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67319468
37ZNF263_19887448_ChIP-Seq_K562_Human1.67307961
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54311749
39* KDM2B_26808549_Chip-Seq_K562_Human1.48980881
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.43557909
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41423306
42* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41351630
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40997113
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40992015
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40867788
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39323427
47SMAD4_21799915_ChIP-Seq_A2780_Human1.39130390
48* KDM2B_26808549_Chip-Seq_DND41_Human1.38145058
49* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37052099
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36766795
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36693909
52SMC4_20622854_ChIP-Seq_HELA_Human1.34133007
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32844361
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32230040
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.31932599
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31197291
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29957036
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29214094
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25411604
60* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24938604
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.24322666
62AR_19668381_ChIP-Seq_PC3_Human1.24304537
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22686359
64* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22070392
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.21930214
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20100501
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19657649
68* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18850796
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18363303
70* CREB1_26743006_Chip-Seq_LNCaP_Human1.18107485
71ZNF274_21170338_ChIP-Seq_K562_Hela1.17440648
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17250115
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16053476
74TCF7_22412390_ChIP-Seq_EML_Mouse1.15605450
75* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14102927
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12469334
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.11472111
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10796958
79AHR_22903824_ChIP-Seq_MCF-7_Human1.09628996
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09562958
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.09153392
82* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08675746
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08136322
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07951079
85* TP53_23651856_ChIP-Seq_MEFs_Mouse1.07924073
86P68_20966046_ChIP-Seq_HELA_Human1.06775913
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.05832934
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05471122
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03934514
90* STAT3_23295773_ChIP-Seq_U87_Human1.03106407
91AR_25329375_ChIP-Seq_VCAP_Human1.02501202
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02156461
93TAF15_26573619_Chip-Seq_HEK293_Human1.01724918
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00872524
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99773806
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.98974426
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.98481797
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98146070
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.97841281
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97433471
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97400344
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.96859346
103CLOCK_20551151_ChIP-Seq_293T_Human0.96837752
104* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96230914
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.95999775
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95964254
107* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95121592
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94895117
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94860022
110* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94449283
111* CTCF_27219007_Chip-Seq_Bcells_Human0.94395639
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94282631
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93381447
114EGR1_19032775_ChIP-ChIP_M12_Human0.93235705
115P300_19829295_ChIP-Seq_ESCs_Human0.92968609
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.91342287
117* TP63_22573176_ChIP-Seq_HFKS_Human0.90439197
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.90358762
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90162570
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89969011
121* TCF4_23295773_ChIP-Seq_U87_Human0.89766379
122TP53_16413492_ChIP-PET_HCT116_Human0.88174481
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.88040175
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.87855176
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87119629
126* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87108440
127KLF4_19829295_ChIP-Seq_ESCs_Human0.86588195
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85508087
129* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84475509
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83031685
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82691443
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82496806
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82145982
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.82013827
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81760158
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79696675
137RNF2_27304074_Chip-Seq_NSC_Mouse0.79576089
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78814872
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78488289
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78353286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.84436403
2MP0003880_abnormal_central_pattern4.35233614
3MP0003635_abnormal_synaptic_transmissio4.18005694
4MP0004270_analgesia3.84476164
5MP0002063_abnormal_learning/memory/cond3.27774247
6MP0009745_abnormal_behavioral_response3.27644021
7MP0002064_seizures3.07848322
8MP0009046_muscle_twitch2.98982011
9MP0005423_abnormal_somatic_nervous2.95696070
10MP0001968_abnormal_touch/_nociception2.74853191
11MP0000579_abnormal_nail_morphology2.73815195
12MP0002734_abnormal_mechanical_nocicepti2.66088071
13MP0002572_abnormal_emotion/affect_behav2.62314485
14MP0002822_catalepsy2.55786483
15MP0001486_abnormal_startle_reflex2.53613648
16MP0002272_abnormal_nervous_system2.51488605
17MP0009780_abnormal_chondrocyte_physiolo2.42343706
18MP0000566_synostosis2.41176941
19MP0003705_abnormal_hypodermis_morpholog2.17083862
20MP0004858_abnormal_nervous_system2.16505577
21MP0001501_abnormal_sleep_pattern2.10121435
22MP0008569_lethality_at_weaning2.02367613
23MP0003329_amyloid_beta_deposits1.95958212
24MP0002736_abnormal_nociception_after1.95315826
25MP0001440_abnormal_grooming_behavior1.92084637
26MP0005409_darkened_coat_color1.92039511
27MP0002733_abnormal_thermal_nociception1.89821421
28MP0001970_abnormal_pain_threshold1.85349054
29MP0004811_abnormal_neuron_physiology1.84969658
30MP0002067_abnormal_sensory_capabilities1.82277195
31MP0002909_abnormal_adrenal_gland1.81925670
32MP0002735_abnormal_chemical_nociception1.80729097
33MP0000778_abnormal_nervous_system1.78945724
34MP0004885_abnormal_endolymph1.78713046
35MP0002184_abnormal_innervation1.78174612
36MP0003879_abnormal_hair_cell1.77836446
37MP0001984_abnormal_olfaction1.71040652
38MP0002557_abnormal_social/conspecific_i1.68618604
39MP0005386_behavior/neurological_phenoty1.59774754
40MP0004924_abnormal_behavior1.59774754
41MP0000955_abnormal_spinal_cord1.59593203
42MP0004782_abnormal_surfactant_physiolog1.53087185
43MP0002882_abnormal_neuron_morphology1.52541886
44MP0003123_paternal_imprinting1.45695499
45MP0001348_abnormal_lacrimal_gland1.44421948
46MP0005551_abnormal_eye_electrophysiolog1.42062523
47MP0003633_abnormal_nervous_system1.38434521
48MP0002066_abnormal_motor_capabilities/c1.38333224
49MP0000537_abnormal_urethra_morphology1.37497007
50MP0001849_ear_inflammation1.36408342
51MP0005646_abnormal_pituitary_gland1.33835236
52MP0003283_abnormal_digestive_organ1.33007955
53MP0002089_abnormal_postnatal_growth/wei1.25717887
54MP0002249_abnormal_larynx_morphology1.24714161
55MP0001502_abnormal_circadian_rhythm1.22663127
56MP0003566_abnormal_cell_adhesion1.22647422
57MP0003787_abnormal_imprinting1.21033734
58MP0010234_abnormal_vibrissa_follicle1.18497922
59MP0001346_abnormal_lacrimal_gland1.15458617
60MP0003631_nervous_system_phenotype1.15392403
61MP0002152_abnormal_brain_morphology1.14244113
62MP0000751_myopathy1.13127402
63MP0002229_neurodegeneration1.10511024
64MP0005394_taste/olfaction_phenotype1.10219579
65MP0005499_abnormal_olfactory_system1.10219579
66MP0005623_abnormal_meninges_morphology1.08435446
67MP0000569_abnormal_digit_pigmentation1.07495822
68MP0006276_abnormal_autonomic_nervous1.07460623
69MP0008961_abnormal_basal_metabolism1.07353966
70MP0000462_abnormal_digestive_system1.07148816
71MP0005645_abnormal_hypothalamus_physiol1.06372495
72MP0003183_abnormal_peptide_metabolism1.04999340
73MP0001177_atelectasis1.02715574
74MP0003075_altered_response_to0.99605922
75MP0004145_abnormal_muscle_electrophysio0.97609413
76MP0008438_abnormal_cutaneous_collagen0.97306144
77MP0000762_abnormal_tongue_morphology0.96227670
78MP0001958_emphysema0.95343105
79MP0000013_abnormal_adipose_tissue0.94929707
80MP0002133_abnormal_respiratory_system0.94655151
81MP0005388_respiratory_system_phenotype0.94655151
82MP0003634_abnormal_glial_cell0.94045989
83MP0008872_abnormal_physiological_respon0.93598667
84MP0004142_abnormal_muscle_tone0.93285858
85MP0002090_abnormal_vision0.93159436
86MP0002877_abnormal_melanocyte_morpholog0.90589122
87MP0002069_abnormal_eating/drinking_beha0.89764974
88MP0005257_abnormal_intraocular_pressure0.88527943
89MP0003690_abnormal_glial_cell0.86341862
90MP0003632_abnormal_nervous_system0.85935624
91MP0001905_abnormal_dopamine_level0.85542964
92MP0003122_maternal_imprinting0.85522221
93MP0005167_abnormal_blood-brain_barrier0.85258916
94MP0002752_abnormal_somatic_nervous0.85169976
95MP0010030_abnormal_orbit_morphology0.84616053
96MP0006072_abnormal_retinal_apoptosis0.82629045
97MP0001963_abnormal_hearing_physiology0.82184747
98MP0008874_decreased_physiological_sensi0.81634941
99MP0004233_abnormal_muscle_weight0.81539969
100MP0004085_abnormal_heartbeat0.80187478
101MP0004742_abnormal_vestibular_system0.78892314
102MP0002295_abnormal_pulmonary_circulatio0.78537261
103MP0001485_abnormal_pinna_reflex0.78535367
104MP0000604_amyloidosis0.78125432
105MP0002653_abnormal_ependyma_morphology0.77070375
106MP0004272_abnormal_basement_membrane0.76453685
107MP0000920_abnormal_myelination0.75585053
108MP0005076_abnormal_cell_differentiation0.74306233
109MP0000631_abnormal_neuroendocrine_gland0.72415815
110MP0005253_abnormal_eye_physiology0.72152696
111MP0003453_abnormal_keratinocyte_physiol0.72039367
112MP0001299_abnormal_eye_distance/0.71794802
113MP0010386_abnormal_urinary_bladder0.71728166
114MP0000678_abnormal_parathyroid_gland0.71378496
115MP0005187_abnormal_penis_morphology0.70009402
116MP0005275_abnormal_skin_tensile0.68927595
117MP0005535_abnormal_body_temperature0.66411944
118MP0004215_abnormal_myocardial_fiber0.64281250
119MP0001529_abnormal_vocalization0.63609669
120MP0003861_abnormal_nervous_system0.63147201
121MP0003137_abnormal_impulse_conducting0.62496492
122MP0003091_abnormal_cell_migration0.62191917
123MP0004043_abnormal_pH_regulation0.61308425
124MP0002234_abnormal_pharynx_morphology0.61283265
125MP0004484_altered_response_of0.61122510
126MP0000467_abnormal_esophagus_morphology0.59407340
127MP0001943_abnormal_respiration0.58289574
128MP0001664_abnormal_digestion0.57801790
129MP0001851_eye_inflammation0.57470794
130MP0000534_abnormal_ureter_morphology0.55236581
131MP0010769_abnormal_survival0.54355258
132MP0002638_abnormal_pupillary_reflex0.53452360

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.62701122
2Focal motor seizures (HP:0011153)6.49796314
3Focal seizures (HP:0007359)5.29156570
4Visual hallucinations (HP:0002367)5.21583036
5Epileptic encephalopathy (HP:0200134)4.31046394
6Action tremor (HP:0002345)4.21836446
7Atonic seizures (HP:0010819)4.07649893
8Progressive cerebellar ataxia (HP:0002073)3.93312618
9Febrile seizures (HP:0002373)3.82047827
10Supranuclear gaze palsy (HP:0000605)3.68302590
11Ankle clonus (HP:0011448)3.66861725
12Absence seizures (HP:0002121)3.62585488
13Generalized tonic-clonic seizures (HP:0002069)3.46947325
14Depression (HP:0000716)3.29245013
15Dialeptic seizures (HP:0011146)3.23087490
16Poor eye contact (HP:0000817)3.18567699
17Broad-based gait (HP:0002136)3.15788357
18Impaired vibration sensation in the lower limbs (HP:0002166)3.12150964
19Dysdiadochokinesis (HP:0002075)3.12148238
20Hyperacusis (HP:0010780)3.09525341
21Urinary bladder sphincter dysfunction (HP:0002839)3.08156927
22Abnormality of the lower motor neuron (HP:0002366)3.06697038
23Mutism (HP:0002300)3.05509336
24Gaze-evoked nystagmus (HP:0000640)3.04402278
25Cerebral aneurysm (HP:0004944)3.01571281
26Postural instability (HP:0002172)3.01196410
27Atrophic scars (HP:0001075)2.97677997
28Papilledema (HP:0001085)2.95689210
29Abnormal social behavior (HP:0012433)2.93308792
30Impaired social interactions (HP:0000735)2.93308792
31Bronchomalacia (HP:0002780)2.90687465
32Genetic anticipation (HP:0003743)2.84961808
33Dysmetria (HP:0001310)2.84647519
34Shallow orbits (HP:0000586)2.83562789
35Truncal ataxia (HP:0002078)2.79656155
36Ventricular fibrillation (HP:0001663)2.75164160
37Anxiety (HP:0000739)2.74670173
38Amblyopia (HP:0000646)2.74266889
39Urinary urgency (HP:0000012)2.70528434
40Megalencephaly (HP:0001355)2.64040990
41Impaired smooth pursuit (HP:0007772)2.63407496
42Torticollis (HP:0000473)2.62894904
43Hemiplegia (HP:0002301)2.62549318
44Intention tremor (HP:0002080)2.61671970
45Abnormal eating behavior (HP:0100738)2.58761224
46Turricephaly (HP:0000262)2.54915377
47Insomnia (HP:0100785)2.52637344
48Cerebral inclusion bodies (HP:0100314)2.52459715
49Ulnar bowing (HP:0003031)2.50725988
50Hemiparesis (HP:0001269)2.46352754
51Neurofibrillary tangles (HP:0002185)2.46147231
52Spastic gait (HP:0002064)2.46136516
53Termporal pattern (HP:0011008)2.45744614
54Insidious onset (HP:0003587)2.45744614
55Dysmetric saccades (HP:0000641)2.45267811
56Annular pancreas (HP:0001734)2.41167524
57Bradykinesia (HP:0002067)2.39142185
58Focal dystonia (HP:0004373)2.38034841
59Overriding aorta (HP:0002623)2.36026760
60Scanning speech (HP:0002168)2.32543967
61Protrusio acetabuli (HP:0003179)2.31668651
62Drooling (HP:0002307)2.31642631
63Excessive salivation (HP:0003781)2.31642631
64Abnormality of binocular vision (HP:0011514)2.30930907
65Diplopia (HP:0000651)2.30930907
66Abnormality of ocular smooth pursuit (HP:0000617)2.30857506
67Stereotypic behavior (HP:0000733)2.30504471
68Hyperventilation (HP:0002883)2.29959607
69Distal upper limb amyotrophy (HP:0007149)2.29135509
70Upper limb amyotrophy (HP:0009129)2.29135509
71Milia (HP:0001056)2.28295457
72Pointed chin (HP:0000307)2.27365879
73Tetraplegia (HP:0002445)2.24576473
74Akinesia (HP:0002304)2.22790390
75Abnormality of the corticospinal tract (HP:0002492)2.20480280
76Lower limb muscle weakness (HP:0007340)2.19924726
77Arterial tortuosity (HP:0005116)2.16827875
78Central scotoma (HP:0000603)2.16491501
79Bundle branch block (HP:0011710)2.15995170
80Craniofacial dystonia (HP:0012179)2.13576179
81Sleep apnea (HP:0010535)2.13550935
82Progressive inability to walk (HP:0002505)2.12558093
83Epileptiform EEG discharges (HP:0011182)2.10304035
84Obstructive sleep apnea (HP:0002870)2.08204116
85Impaired vibratory sensation (HP:0002495)2.07498429
86EEG with generalized epileptiform discharges (HP:0011198)2.06447621
87Hand muscle atrophy (HP:0009130)2.05682175
88Bladder diverticulum (HP:0000015)2.05122563
89Vascular tortuosity (HP:0004948)2.04151459
90Fetal akinesia sequence (HP:0001989)2.03340974
91Status epilepticus (HP:0002133)2.01289423
92Elfin facies (HP:0004428)2.00382214
93Fragile skin (HP:0001030)2.00191763
94Hypsarrhythmia (HP:0002521)1.99183127
95Diminished motivation (HP:0000745)1.93050698
96Pheochromocytoma (HP:0002666)1.92451062
97Agitation (HP:0000713)1.92376771
98Athetosis (HP:0002305)1.91723289
99Rapidly progressive (HP:0003678)1.91400116
100Hypoplasia of dental enamel (HP:0006297)1.91213657
101Fragile nails (HP:0001808)1.89786509
102Clonus (HP:0002169)1.89763476
103Abnormality of nail color (HP:0100643)1.89713488
104Aplasia involving bones of the upper limbs (HP:0009823)1.89491621
105Aplasia of the phalanges of the hand (HP:0009802)1.89491621
106Aplasia involving bones of the extremities (HP:0009825)1.89491621
107Lower limb amyotrophy (HP:0007210)1.87567293
108Absent speech (HP:0001344)1.87177324
109Resting tremor (HP:0002322)1.86770191
110Ankyloglossia (HP:0010296)1.86282786
111Split foot (HP:0001839)1.85604420
112Broad face (HP:0000283)1.85475837
113Premature rupture of membranes (HP:0001788)1.85351993
114Amyotrophic lateral sclerosis (HP:0007354)1.84693621
115Lower limb asymmetry (HP:0100559)1.84272568
116Limb dystonia (HP:0002451)1.84131842
117Neuronal loss in central nervous system (HP:0002529)1.82867595
118Hypoventilation (HP:0002791)1.81622030
119Apathy (HP:0000741)1.81545577
120Broad metatarsal (HP:0001783)1.80383124
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80216868
122Gait ataxia (HP:0002066)1.79853008
123Renal duplication (HP:0000075)1.79271205
124Incomplete penetrance (HP:0003829)1.79165243
125Abnormal EKG (HP:0003115)1.78928201
126Abnormality of macular pigmentation (HP:0008002)1.78682244
127Generalized myoclonic seizures (HP:0002123)1.76467692
128Peripheral hypomyelination (HP:0007182)1.73893298
129Rigidity (HP:0002063)1.73074185
130Arnold-Chiari malformation (HP:0002308)1.71210944
131Neonatal short-limb short stature (HP:0008921)1.70433833
132Intellectual disability, profound (HP:0002187)1.70271572
133Inappropriate behavior (HP:0000719)1.68684685
134Bowel diverticulosis (HP:0005222)1.68388802
135Spastic tetraparesis (HP:0001285)1.68069201
136Hammertoe (HP:0001765)1.67420625
137Abnormality of saccadic eye movements (HP:0000570)1.67138231
138Renovascular hypertension (HP:0100817)1.67108879
139Cerebral hypomyelination (HP:0006808)1.64629500
140Spinal cord compression (HP:0002176)1.63706942
141Precocious puberty (HP:0000826)1.63575640
142Onycholysis (HP:0001806)1.62760028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.10160852
2EPHA44.02666731
3NTRK33.92325090
4MARK13.06700386
5DAPK23.01247126
6MAP3K42.86749920
7MINK12.61525932
8PAK62.55050303
9PRKD32.53363505
10KSR22.27349808
11CAMKK12.11740300
12NTRK12.11666485
13MAP2K72.09697006
14NTRK22.05344514
15MAP2K41.71663806
16CDK51.58226186
17STK381.55263120
18DAPK11.53863239
19TYRO31.52660289
20KSR11.51994610
21RIPK41.45168994
22SIK11.43320343
23MAP3K21.41605754
24SIK21.37985314
25EEF2K1.34145404
26GRK51.33959822
27PLK21.32703328
28MAP3K121.30140629
29EPHA21.26410835
30CDK191.23911016
31TAOK11.23624828
32LATS21.22389717
33PHKG11.18156311
34PHKG21.18156311
35RIPK11.15508420
36UHMK11.13509120
37SMG11.13007187
38PRPF4B1.12975006
39PNCK1.11829605
40PRKCG1.09686248
41MAPK131.05490954
42ARAF1.05452566
43LMTK21.04949170
44RET1.03360931
45PTK21.03219536
46STK111.03217922
47PRKCH1.02924068
48ALK1.02242319
49CAMKK21.01709337
50CDK121.01303698
51CASK0.98913596
52CAMK10.93002980
53CDK150.90992517
54PAK30.90938842
55CDK180.90080608
56SGK2230.89996207
57SGK4940.89996207
58TNIK0.87324269
59MST1R0.86546866
60PINK10.86452365
61CDK140.85904623
62DDR20.84515953
63MET0.84240770
64MAP3K130.84178182
65FES0.83052146
66PRKD20.80984962
67CAMK2A0.80342157
68CDK11A0.78884917
69EPHB20.77766031
70PTK2B0.74694269
71CAMK1D0.74222591
72TESK10.74079834
73SGK30.72238491
74MARK20.70423428
75SCYL20.69974618
76NEK10.69246683
77BRAF0.68432812
78CAMK1G0.68271799
79OXSR10.66198650
80RAF10.65902615
81ERN10.64884224
82SGK20.64472586
83SGK10.63716261
84PDK10.63634996
85DYRK1A0.63156548
86CSNK1G20.63034539
87CDC42BPA0.61921806
88PDPK10.61824270
89WNK10.61698977
90CAMK2B0.60021749
91MTOR0.59298951
92MAP3K10.58340454
93FER0.57713436
94MAPK120.56490429
95FGFR40.55552415
96TRIB30.54447114
97MAP3K70.53899259
98TNK20.52616157
99PRKCZ0.52470264
100MOS0.51688413
101RPS6KA30.50981391
102PAK20.50300562
103CAMK40.50091568
104DAPK30.50018370
105PDGFRA0.47868594
106FGFR20.46068152
107TTN0.45928797
108FYN0.45520823
109ICK0.45344770
110MAPK100.45309290
111MAP2K10.43915419
112DMPK0.43742574
113BMX0.42436139
114BRSK10.41898049
115ERBB20.41732642
116RPS6KA20.41621353
117NEK60.41273347
118PDGFRB0.41188516
119PRKG20.39937122
120ROCK10.38856202
121CAMK2D0.38170815
122LIMK10.37895022
123CAMK2G0.37379403
124PRKCE0.37068651
125ROCK20.36989890
126BMPR20.35850326

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.24040775
2Nicotine addiction_Homo sapiens_hsa050333.09514414
3Olfactory transduction_Homo sapiens_hsa047402.87965398
4Circadian entrainment_Homo sapiens_hsa047132.53526281
5GABAergic synapse_Homo sapiens_hsa047272.49192594
6Long-term potentiation_Homo sapiens_hsa047202.46495511
7Glutamatergic synapse_Homo sapiens_hsa047242.39237727
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37572797
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35311417
10Morphine addiction_Homo sapiens_hsa050322.24639345
11Amphetamine addiction_Homo sapiens_hsa050312.21446359
12Salivary secretion_Homo sapiens_hsa049702.13881898
13Dopaminergic synapse_Homo sapiens_hsa047282.03281754
14Insulin secretion_Homo sapiens_hsa049111.99937982
15Gastric acid secretion_Homo sapiens_hsa049711.99018316
16Cholinergic synapse_Homo sapiens_hsa047251.87354653
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82853173
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72669641
19Phototransduction_Homo sapiens_hsa047441.65110721
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61644138
21Oxytocin signaling pathway_Homo sapiens_hsa049211.61202735
22Renin secretion_Homo sapiens_hsa049241.55989764
23Taste transduction_Homo sapiens_hsa047421.54533559
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51680720
25Long-term depression_Homo sapiens_hsa047301.51208247
26Cocaine addiction_Homo sapiens_hsa050301.47286697
27GnRH signaling pathway_Homo sapiens_hsa049121.47013293
28Calcium signaling pathway_Homo sapiens_hsa040201.42285639
29Serotonergic synapse_Homo sapiens_hsa047261.37177512
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34815184
31Gap junction_Homo sapiens_hsa045401.34034665
32Nitrogen metabolism_Homo sapiens_hsa009101.29514381
33Type II diabetes mellitus_Homo sapiens_hsa049301.28013689
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26356768
35Estrogen signaling pathway_Homo sapiens_hsa049151.25719286
36cAMP signaling pathway_Homo sapiens_hsa040241.25325920
37Glioma_Homo sapiens_hsa052141.25035864
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17673133
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16758197
40Collecting duct acid secretion_Homo sapiens_hsa049661.12523259
41Axon guidance_Homo sapiens_hsa043601.11393609
42Melanogenesis_Homo sapiens_hsa049161.10953572
43ECM-receptor interaction_Homo sapiens_hsa045121.09038123
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08210135
45ErbB signaling pathway_Homo sapiens_hsa040121.05146839
46Pancreatic secretion_Homo sapiens_hsa049720.93746758
47Dorso-ventral axis formation_Homo sapiens_hsa043200.93446555
48Vitamin B6 metabolism_Homo sapiens_hsa007500.92082048
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90316038
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.89107347
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.88907383
52Thyroid hormone synthesis_Homo sapiens_hsa049180.87002227
53Oocyte meiosis_Homo sapiens_hsa041140.86781006
54Focal adhesion_Homo sapiens_hsa045100.86201876
55Dilated cardiomyopathy_Homo sapiens_hsa054140.84357068
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84162509
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82512697
58Cardiac muscle contraction_Homo sapiens_hsa042600.81849601
59Vibrio cholerae infection_Homo sapiens_hsa051100.81251023
60Notch signaling pathway_Homo sapiens_hsa043300.79453567
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74921769
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.74809762
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74409073
64Amoebiasis_Homo sapiens_hsa051460.74344029
65VEGF signaling pathway_Homo sapiens_hsa043700.71638508
66Choline metabolism in cancer_Homo sapiens_hsa052310.71143725
67mTOR signaling pathway_Homo sapiens_hsa041500.70920983
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70888571
69MAPK signaling pathway_Homo sapiens_hsa040100.69528912
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68273361
71AMPK signaling pathway_Homo sapiens_hsa041520.65957840
72Adherens junction_Homo sapiens_hsa045200.64091351
73Endometrial cancer_Homo sapiens_hsa052130.64049256
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61977346
75Proteoglycans in cancer_Homo sapiens_hsa052050.61648403
76Rap1 signaling pathway_Homo sapiens_hsa040150.61342051
77Bile secretion_Homo sapiens_hsa049760.60446040
78Chronic myeloid leukemia_Homo sapiens_hsa052200.60019045
79Endocytosis_Homo sapiens_hsa041440.59783749
80Glucagon signaling pathway_Homo sapiens_hsa049220.59396050
81Protein digestion and absorption_Homo sapiens_hsa049740.59301731
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58132918
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57383739
84Ras signaling pathway_Homo sapiens_hsa040140.57129375
85Inositol phosphate metabolism_Homo sapiens_hsa005620.55623881
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.54392565
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54297381
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53860368
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52911936
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52705951
91Non-small cell lung cancer_Homo sapiens_hsa052230.52451389
92Renal cell carcinoma_Homo sapiens_hsa052110.51670363
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51001253
94Insulin signaling pathway_Homo sapiens_hsa049100.50716654
95Wnt signaling pathway_Homo sapiens_hsa043100.49295588
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47319495
97HIF-1 signaling pathway_Homo sapiens_hsa040660.47251587
98Alcoholism_Homo sapiens_hsa050340.47172388
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45161288
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44476590
101Circadian rhythm_Homo sapiens_hsa047100.43407555
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43058317
103Prion diseases_Homo sapiens_hsa050200.42013955
104Tight junction_Homo sapiens_hsa045300.41323686
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39193712
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.38924681
107Mineral absorption_Homo sapiens_hsa049780.38369397
108Folate biosynthesis_Homo sapiens_hsa007900.38106732
109Colorectal cancer_Homo sapiens_hsa052100.36746604
110Ovarian steroidogenesis_Homo sapiens_hsa049130.36570486
111Chemokine signaling pathway_Homo sapiens_hsa040620.35047152
112Type I diabetes mellitus_Homo sapiens_hsa049400.34338268
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32732010
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31789049
115Hippo signaling pathway_Homo sapiens_hsa043900.31597146
116Prolactin signaling pathway_Homo sapiens_hsa049170.30698303
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30538546
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28736843

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