CLSTN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89862909
2locomotory exploration behavior (GO:0035641)5.66192781
3glutamate secretion (GO:0014047)5.56849928
4synaptic vesicle maturation (GO:0016188)5.53906196
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35042378
6synaptic vesicle exocytosis (GO:0016079)5.28005926
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27792618
8vocalization behavior (GO:0071625)5.27465171
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23667520
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.12260710
11neuron cell-cell adhesion (GO:0007158)4.99241868
12regulation of glutamate receptor signaling pathway (GO:1900449)4.94879350
13regulation of synaptic vesicle exocytosis (GO:2000300)4.89001537
14protein localization to synapse (GO:0035418)4.66328897
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.59070571
16exploration behavior (GO:0035640)4.57892770
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47180078
18regulation of synaptic vesicle transport (GO:1902803)4.42092586
19regulation of neuronal synaptic plasticity (GO:0048168)4.28752208
20sensory perception of smell (GO:0007608)4.26358130
21neurotransmitter secretion (GO:0007269)4.25217843
22synaptic transmission, glutamatergic (GO:0035249)4.20600812
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17131976
24glutamate receptor signaling pathway (GO:0007215)4.14416942
25neuronal action potential propagation (GO:0019227)4.06658763
26gamma-aminobutyric acid transport (GO:0015812)4.05167894
27regulation of synapse structural plasticity (GO:0051823)4.02365718
28neurotransmitter-gated ion channel clustering (GO:0072578)4.01685148
29layer formation in cerebral cortex (GO:0021819)3.99143818
30neuron-neuron synaptic transmission (GO:0007270)3.89050620
31neuron recognition (GO:0008038)3.84570700
32axonal fasciculation (GO:0007413)3.83880454
33proline transport (GO:0015824)3.81906898
34positive regulation of synapse maturation (GO:0090129)3.81497605
35cellular potassium ion homeostasis (GO:0030007)3.80524136
36long-term memory (GO:0007616)3.79890289
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79676733
38neuronal ion channel clustering (GO:0045161)3.77120823
39activation of protein kinase A activity (GO:0034199)3.76497979
40dendritic spine morphogenesis (GO:0060997)3.75259011
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66929484
42regulation of synaptic plasticity (GO:0048167)3.56550070
43positive regulation of membrane potential (GO:0045838)3.54935923
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.54026726
45postsynaptic membrane organization (GO:0001941)3.51086727
46regulation of postsynaptic membrane potential (GO:0060078)3.49861522
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48367160
48cerebellar Purkinje cell differentiation (GO:0021702)3.47277103
49synaptic vesicle endocytosis (GO:0048488)3.44886429
50neurotransmitter transport (GO:0006836)3.44413030
51dendrite morphogenesis (GO:0048813)3.43405898
52regulation of neurotransmitter secretion (GO:0046928)3.42612824
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39322273
54sodium ion export (GO:0071436)3.36518564
55long-term synaptic potentiation (GO:0060291)3.33609548
56innervation (GO:0060384)3.30214688
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30123101
58cell communication by electrical coupling (GO:0010644)3.30030962
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27604119
60regulation of dendritic spine morphogenesis (GO:0061001)3.25259571
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.24716725
62membrane depolarization during action potential (GO:0086010)3.23388074
63neuromuscular synaptic transmission (GO:0007274)3.22722326
64transmission of nerve impulse (GO:0019226)3.22352906
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.19613800
66regulation of neurotransmitter levels (GO:0001505)3.17783582
67presynaptic membrane assembly (GO:0097105)3.16858684
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16555101
69central nervous system projection neuron axonogenesis (GO:0021952)3.15223035
70pyrimidine nucleobase catabolic process (GO:0006208)3.13222963
71regulation of neurotransmitter transport (GO:0051588)3.11848812
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11184551
73neuromuscular process controlling balance (GO:0050885)3.10021691
74membrane depolarization (GO:0051899)3.09533563
75regulation of synapse maturation (GO:0090128)3.09452962
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09110542
77vesicle transport along microtubule (GO:0047496)3.08662601
78synapse assembly (GO:0007416)3.07122955
79response to auditory stimulus (GO:0010996)3.06921405
80cell migration in hindbrain (GO:0021535)3.05945113
81regulation of vesicle fusion (GO:0031338)3.03951108
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03039530
83auditory behavior (GO:0031223)3.02625731
84positive regulation of neurotransmitter secretion (GO:0001956)3.00780837
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00578346
86regulation of synaptic transmission (GO:0050804)2.99038642
87synaptic transmission (GO:0007268)2.98937320
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96969311
89presynaptic membrane organization (GO:0097090)2.95891103
90learning (GO:0007612)2.93980867
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92173520
92positive regulation of neurotransmitter transport (GO:0051590)2.91643930
93membrane hyperpolarization (GO:0060081)2.91616166
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.90733273
95behavioral defense response (GO:0002209)2.90304205
96behavioral fear response (GO:0001662)2.90304205
97response to histamine (GO:0034776)2.88794929
98detection of calcium ion (GO:0005513)2.86828145
99neuromuscular process controlling posture (GO:0050884)2.85518132
100dendritic spine organization (GO:0097061)2.85311884
101intraspecies interaction between organisms (GO:0051703)2.85037567
102social behavior (GO:0035176)2.85037567
103urinary tract smooth muscle contraction (GO:0014848)2.84784119
104positive regulation of synaptic transmission (GO:0050806)2.84502456
105cerebellar granule cell differentiation (GO:0021707)2.84258120
106cell communication involved in cardiac conduction (GO:0086065)2.83322828
107positive regulation of dendritic spine development (GO:0060999)2.82683093
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80965278
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78103243
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.77633801
111axon extension involved in axon guidance (GO:0048846)2.77633801
112negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.73118855
113central nervous system myelination (GO:0022010)2.72627171
114axon ensheathment in central nervous system (GO:0032291)2.72627171
115axon extension (GO:0048675)2.70182085
116myelination in peripheral nervous system (GO:0022011)2.69234026
117peripheral nervous system axon ensheathment (GO:0032292)2.69234026
118regulation of phospholipase A2 activity (GO:0032429)2.67754318
119positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65429191
120regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60021238
121regulation of voltage-gated calcium channel activity (GO:1901385)2.58713412
122cellular sodium ion homeostasis (GO:0006883)2.54999105
123potassium ion homeostasis (GO:0055075)2.52608475
124potassium ion import (GO:0010107)2.51649900
125nucleobase catabolic process (GO:0046113)2.51211371
126startle response (GO:0001964)2.50674748
127cellular response to catecholamine stimulus (GO:0071870)2.49323921
128cellular response to monoamine stimulus (GO:0071868)2.49323921
129establishment of nucleus localization (GO:0040023)2.44138673
130relaxation of smooth muscle (GO:0044557)2.43399972
131positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.41499561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.49092631
2* GBX2_23144817_ChIP-Seq_PC3_Human3.58005900
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01828638
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99322920
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93189560
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68413697
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68413697
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.59997680
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59350182
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58468768
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57961031
12DROSHA_22980978_ChIP-Seq_HELA_Human2.57245580
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52993046
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44066965
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41904654
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.41052088
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.35944034
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35682842
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.25481055
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.19104082
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18631141
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.16653062
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14353192
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05487953
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.03390566
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95999514
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84688134
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80253441
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.70300284
30AR_21572438_ChIP-Seq_LNCaP_Human1.70106471
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.68919683
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67834900
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64922074
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62693910
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62166450
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61122797
37TAF15_26573619_Chip-Seq_HEK293_Human1.59534248
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53848738
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53737667
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50065506
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43523985
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43052803
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.40692514
44* P300_19829295_ChIP-Seq_ESCs_Human1.39975606
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.39475097
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39250370
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.39138606
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36521417
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.34116718
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.31569291
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30735579
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30055736
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29661154
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.29534187
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.28477134
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28154616
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26636496
58STAT3_23295773_ChIP-Seq_U87_Human1.24633707
59ZNF274_21170338_ChIP-Seq_K562_Hela1.24518846
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23571931
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22526519
62AR_19668381_ChIP-Seq_PC3_Human1.22427347
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22111637
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.21798017
65AR_25329375_ChIP-Seq_VCAP_Human1.21357247
66IGF1R_20145208_ChIP-Seq_DFB_Human1.20389856
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18967625
68AHR_22903824_ChIP-Seq_MCF-7_Human1.17657398
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.17171806
70RNF2_27304074_Chip-Seq_NSC_Mouse1.16980165
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15495719
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15402569
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13780324
74* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12668816
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12362733
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.12303837
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11257095
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08513158
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08125795
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.08018599
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07627186
82* TCF4_23295773_ChIP-Seq_U87_Human1.06468674
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05059207
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04324489
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03580436
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03105161
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02590212
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01974274
89KDM2B_26808549_Chip-Seq_K562_Human1.01332333
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01250322
91* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01044990
92* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01044990
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98738219
94* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98410952
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.97748679
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96979206
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96943651
98* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96693462
99RXR_22108803_ChIP-Seq_LS180_Human0.96265710
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95671262
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.95122967
102* RUNX2_22187159_ChIP-Seq_PCA_Human0.94970739
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93530095
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93260485
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92249131
106TP53_16413492_ChIP-PET_HCT116_Human0.91774990
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91525529
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91124779
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90766434
110TP53_18474530_ChIP-ChIP_U2OS_Human0.90492481
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90442758
112JUN_21703547_ChIP-Seq_K562_Human0.89612798
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89172013
114FUS_26573619_Chip-Seq_HEK293_Human0.88054882
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87835491
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.87773001
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87749323
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87745492
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87527949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.67858047
2MP0003880_abnormal_central_pattern4.61183825
3MP0003635_abnormal_synaptic_transmissio4.14360481
4MP0001984_abnormal_olfaction3.78251387
5MP0004270_analgesia3.57573454
6MP0002063_abnormal_learning/memory/cond3.29394240
7MP0009745_abnormal_behavioral_response3.27694582
8MP0002064_seizures3.07965231
9MP0009046_muscle_twitch3.00132937
10MP0005423_abnormal_somatic_nervous2.95105787
11MP0001968_abnormal_touch/_nociception2.77679205
12MP0002572_abnormal_emotion/affect_behav2.74729434
13MP0002734_abnormal_mechanical_nocicepti2.72689929
14MP0001486_abnormal_startle_reflex2.57805673
15MP0002272_abnormal_nervous_system2.54684100
16MP0002735_abnormal_chemical_nociception2.52944142
17MP0002822_catalepsy2.26648364
18MP0002184_abnormal_innervation2.22363050
19MP0002736_abnormal_nociception_after2.14819703
20MP0001501_abnormal_sleep_pattern2.13033608
21MP0000778_abnormal_nervous_system2.04555045
22MP0001440_abnormal_grooming_behavior1.99326576
23MP0009780_abnormal_chondrocyte_physiolo1.96346028
24MP0004858_abnormal_nervous_system1.93993700
25MP0002067_abnormal_sensory_capabilities1.93883477
26MP0002733_abnormal_thermal_nociception1.93697932
27MP0001970_abnormal_pain_threshold1.90261059
28MP0004811_abnormal_neuron_physiology1.86845062
29MP0002557_abnormal_social/conspecific_i1.83376156
30MP0005645_abnormal_hypothalamus_physiol1.78079336
31MP0005646_abnormal_pituitary_gland1.76193463
32MP0008569_lethality_at_weaning1.76095559
33MP0003787_abnormal_imprinting1.72201510
34MP0006276_abnormal_autonomic_nervous1.68816126
35MP0005386_behavior/neurological_phenoty1.63638730
36MP0004924_abnormal_behavior1.63638730
37MP0002909_abnormal_adrenal_gland1.63428911
38MP0003879_abnormal_hair_cell1.59096230
39MP0000955_abnormal_spinal_cord1.58712011
40MP0002882_abnormal_neuron_morphology1.55251027
41MP0004084_abnormal_cardiac_muscle1.51739860
42MP0003329_amyloid_beta_deposits1.50940194
43MP0002066_abnormal_motor_capabilities/c1.37451868
44MP0005394_taste/olfaction_phenotype1.36914251
45MP0005499_abnormal_olfactory_system1.36914251
46MP0004272_abnormal_basement_membrane1.33917572
47MP0004885_abnormal_endolymph1.33508598
48MP0005248_abnormal_Harderian_gland1.27611975
49MP0003633_abnormal_nervous_system1.26354522
50MP0003122_maternal_imprinting1.24277063
51MP0002152_abnormal_brain_morphology1.19333291
52MP0002102_abnormal_ear_morphology1.18799545
53MP0001905_abnormal_dopamine_level1.16104403
54MP0001188_hyperpigmentation1.15571818
55MP0000569_abnormal_digit_pigmentation1.13778810
56MP0000534_abnormal_ureter_morphology1.13222503
57MP0001502_abnormal_circadian_rhythm1.11488359
58MP0004036_abnormal_muscle_relaxation1.10408495
59MP0004142_abnormal_muscle_tone1.09429254
60MP0003631_nervous_system_phenotype1.09248017
61MP0005503_abnormal_tendon_morphology1.05274618
62MP0004130_abnormal_muscle_cell1.03867896
63MP0001348_abnormal_lacrimal_gland1.03312552
64MP0003385_abnormal_body_wall1.01794417
65MP0005409_darkened_coat_color1.01629016
66MP0010368_abnormal_lymphatic_system0.99796297
67MP0008438_abnormal_cutaneous_collagen0.99316607
68MP0005670_abnormal_white_adipose0.98604327
69MP0002229_neurodegeneration0.94447000
70MP0001177_atelectasis0.94399255
71MP0002752_abnormal_somatic_nervous0.94373576
72MP0001529_abnormal_vocalization0.93219296
73MP0002108_abnormal_muscle_morphology0.92330600
74MP0005551_abnormal_eye_electrophysiolog0.91830264
75MP0004742_abnormal_vestibular_system0.91067627
76MP0002295_abnormal_pulmonary_circulatio0.89597726
77MP0000751_myopathy0.89200675
78MP0000462_abnormal_digestive_system0.88919498
79MP0001485_abnormal_pinna_reflex0.88414232
80MP0010386_abnormal_urinary_bladder0.88044436
81MP0009250_abnormal_appendicular_skeleto0.87947113
82MP0002069_abnormal_eating/drinking_beha0.87652298
83MP0001963_abnormal_hearing_physiology0.86874609
84MP0003868_abnormal_feces_composition0.86308847
85MP0000749_muscle_degeneration0.84182507
86MP0003634_abnormal_glial_cell0.83452119
87MP0002249_abnormal_larynx_morphology0.82972214
88MP0008872_abnormal_physiological_respon0.82688454
89MP0004145_abnormal_muscle_electrophysio0.82193738
90MP0000631_abnormal_neuroendocrine_gland0.81962237
91MP0005620_abnormal_muscle_contractility0.81047129
92MP0003632_abnormal_nervous_system0.78482121
93MP0008775_abnormal_heart_ventricle0.78481133
94MP0008789_abnormal_olfactory_epithelium0.78282909
95MP0005275_abnormal_skin_tensile0.77418777
96MP0008874_decreased_physiological_sensi0.77342350
97MP0006138_congestive_heart_failure0.77188613
98MP0004085_abnormal_heartbeat0.75989087
99MP0003942_abnormal_urinary_system0.75936841
100MP0003075_altered_response_to0.75470789
101MP0002876_abnormal_thyroid_physiology0.71645549
102MP0001299_abnormal_eye_distance/0.71392205
103MP0004215_abnormal_myocardial_fiber0.69422122
104MP0003283_abnormal_digestive_organ0.68896634
105MP0005535_abnormal_body_temperature0.67973160
106MP0004484_altered_response_of0.67906013
107MP0003861_abnormal_nervous_system0.66785788
108MP0005187_abnormal_penis_morphology0.64839056
109MP0001664_abnormal_digestion0.62850215
110MP0003690_abnormal_glial_cell0.62407300
111MP0003137_abnormal_impulse_conducting0.61692817
112MP0010769_abnormal_survival0.56441926
113MP0002082_postnatal_lethality0.56061526
114MP0010770_preweaning_lethality0.56061526
115MP0000026_abnormal_inner_ear0.55547701
116MP0005623_abnormal_meninges_morphology0.54658911
117MP0000604_amyloidosis0.54025407
118MP0004510_myositis0.53630739
119MP0000013_abnormal_adipose_tissue0.52891814
120MP0010768_mortality/aging0.52693204
121MP0000920_abnormal_myelination0.52295585
122MP0001943_abnormal_respiration0.51828429
123MP0002751_abnormal_autonomic_nervous0.51199476
124MP0002638_abnormal_pupillary_reflex0.51014803
125MP0003183_abnormal_peptide_metabolism0.50128924
126MP0002090_abnormal_vision0.49402766

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.52855395
2Myokymia (HP:0002411)6.75463143
3Focal seizures (HP:0007359)5.71800524
4Febrile seizures (HP:0002373)5.03593771
5Atonic seizures (HP:0010819)4.99284446
6Visual hallucinations (HP:0002367)4.84863161
7Epileptic encephalopathy (HP:0200134)4.81013705
8Progressive cerebellar ataxia (HP:0002073)4.34762767
9Absence seizures (HP:0002121)4.24507225
10Generalized tonic-clonic seizures (HP:0002069)3.89559940
11Dialeptic seizures (HP:0011146)3.85837535
12Action tremor (HP:0002345)3.78941914
13Broad-based gait (HP:0002136)3.48589871
14Hyperventilation (HP:0002883)3.38504790
15Supranuclear gaze palsy (HP:0000605)3.34333960
16Limb dystonia (HP:0002451)3.29586732
17Ankle clonus (HP:0011448)3.18153221
18Gaze-evoked nystagmus (HP:0000640)3.13978290
19Depression (HP:0000716)3.07754361
20Impaired vibration sensation in the lower limbs (HP:0002166)2.99681555
21Amblyopia (HP:0000646)2.99050071
22Mutism (HP:0002300)2.99034410
23Poor eye contact (HP:0000817)2.98214265
24Truncal ataxia (HP:0002078)2.87046019
25Genetic anticipation (HP:0003743)2.86120599
26Dysdiadochokinesis (HP:0002075)2.84354077
27Drooling (HP:0002307)2.82848620
28Excessive salivation (HP:0003781)2.82848620
29Abnormal eating behavior (HP:0100738)2.81492780
30Dysmetria (HP:0001310)2.80438372
31Vitreoretinal degeneration (HP:0000655)2.77003589
32Aortic aneurysm (HP:0004942)2.75678600
33Postural instability (HP:0002172)2.75513330
34Torticollis (HP:0000473)2.73344963
35Impaired social interactions (HP:0000735)2.69017252
36Abnormal social behavior (HP:0012433)2.69017252
37Anxiety (HP:0000739)2.68771516
38Urinary bladder sphincter dysfunction (HP:0002839)2.64638964
39Abnormality of the lower motor neuron (HP:0002366)2.58982337
40Focal dystonia (HP:0004373)2.53578458
41Aplasia involving bones of the extremities (HP:0009825)2.48876276
42Aplasia involving bones of the upper limbs (HP:0009823)2.48876276
43Aplasia of the phalanges of the hand (HP:0009802)2.48876276
44Epileptiform EEG discharges (HP:0011182)2.48428375
45Progressive inability to walk (HP:0002505)2.46738680
46Papilledema (HP:0001085)2.44466027
47Termporal pattern (HP:0011008)2.41762415
48Insidious onset (HP:0003587)2.41762415
49Pheochromocytoma (HP:0002666)2.41611113
50Retinal dysplasia (HP:0007973)2.41154739
51Absent speech (HP:0001344)2.36928310
52Fetal akinesia sequence (HP:0001989)2.36868044
53Hemiplegia (HP:0002301)2.36857033
54Megalencephaly (HP:0001355)2.36562054
55Agitation (HP:0000713)2.34996194
56Urinary urgency (HP:0000012)2.34813581
57Ventricular fibrillation (HP:0001663)2.32301926
58Prolonged QT interval (HP:0001657)2.31954119
59EEG with generalized epileptiform discharges (HP:0011198)2.31835234
60Stereotypic behavior (HP:0000733)2.29984792
61Impaired smooth pursuit (HP:0007772)2.29529243
62Hemiparesis (HP:0001269)2.28128555
63Bradykinesia (HP:0002067)2.27864682
64Spastic gait (HP:0002064)2.26047818
65Scanning speech (HP:0002168)2.25266260
66Diplopia (HP:0000651)2.24604371
67Abnormality of binocular vision (HP:0011514)2.24604371
68Craniofacial dystonia (HP:0012179)2.24069356
69Hyporeflexia of lower limbs (HP:0002600)2.22222145
70Intention tremor (HP:0002080)2.22136092
71Hypsarrhythmia (HP:0002521)2.17156055
72Gait imbalance (HP:0002141)2.16687618
73Abnormality of the corticospinal tract (HP:0002492)2.15301373
74Inability to walk (HP:0002540)2.13403365
75Neuroendocrine neoplasm (HP:0100634)2.13323884
76Cerebral inclusion bodies (HP:0100314)2.11707053
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.11323994
78Sudden death (HP:0001699)2.09260379
79Hypoplasia of the iris (HP:0007676)2.06731506
80Aortic dissection (HP:0002647)2.04948737
81Polyphagia (HP:0002591)2.04434995
82Abnormality of ocular smooth pursuit (HP:0000617)2.03825121
83Inappropriate behavior (HP:0000719)2.03552101
84Abnormality of salivation (HP:0100755)2.03019820
85Neurofibrillary tangles (HP:0002185)2.02852860
86Lower limb muscle weakness (HP:0007340)2.00809190
87Incomplete penetrance (HP:0003829)1.98471079
88Protrusio acetabuli (HP:0003179)1.98103389
89Impaired vibratory sensation (HP:0002495)1.97915030
90Anosmia (HP:0000458)1.97325206
91Blue irides (HP:0000635)1.95182339
92Status epilepticus (HP:0002133)1.92752461
93Specific learning disability (HP:0001328)1.88878374
94Lower limb asymmetry (HP:0100559)1.87571879
95Bowel diverticulosis (HP:0005222)1.86446935
96Abnormal EKG (HP:0003115)1.84741216
97Obstructive sleep apnea (HP:0002870)1.84731117
98Amyotrophic lateral sclerosis (HP:0007354)1.83974728
99Abnormality of the columella (HP:0009929)1.83918958
100Abnormality of the ischium (HP:0003174)1.83915849
101Protruding tongue (HP:0010808)1.83724806
102Buphthalmos (HP:0000557)1.82852957
103Gait ataxia (HP:0002066)1.82830847
104Overgrowth (HP:0001548)1.82242935
105Atrial fibrillation (HP:0005110)1.82193210
106Anterior segment dysgenesis (HP:0007700)1.80916332
107Annular pancreas (HP:0001734)1.80140049
108Generalized myoclonic seizures (HP:0002123)1.79753863
109Dysmetric saccades (HP:0000641)1.79673767
110Aqueductal stenosis (HP:0002410)1.78234362
111Failure to thrive in infancy (HP:0001531)1.78148040
112Shallow orbits (HP:0000586)1.77897043
113Broad metatarsal (HP:0001783)1.77212154
114Primary atrial arrhythmia (HP:0001692)1.75078593
115Syncope (HP:0001279)1.74202387
116Akinesia (HP:0002304)1.73901580
117Morphological abnormality of the pyramidal tract (HP:0002062)1.72098239
118Hypoventilation (HP:0002791)1.71711911
119Hypercortisolism (HP:0001578)1.71057834
120Abnormality of macular pigmentation (HP:0008002)1.70942350
121Pointed chin (HP:0000307)1.70846099
122Nonprogressive disorder (HP:0003680)1.70696602
123Bundle branch block (HP:0011710)1.70090757
124Increased variability in muscle fiber diameter (HP:0003557)1.70050664
125Congenital primary aphakia (HP:0007707)1.69773673
126Arterial tortuosity (HP:0005116)1.68558335
127Pulmonic stenosis (HP:0001642)1.68123750
128Myotonia (HP:0002486)1.66321893
129Insomnia (HP:0100785)1.66128023
130Bradycardia (HP:0001662)1.65875623
131Cutaneous finger syndactyly (HP:0010554)1.65855942
132Steppage gait (HP:0003376)1.63730137
133Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63141172
134Vascular tortuosity (HP:0004948)1.62648608
135Mild short stature (HP:0003502)1.61579915
136Premature rupture of membranes (HP:0001788)1.61155957
137Hepatoblastoma (HP:0002884)1.61152144
138Sleep apnea (HP:0010535)1.61122514
139Supraventricular tachycardia (HP:0004755)1.61038332
140Supraventricular arrhythmia (HP:0005115)1.60978621
141Turricephaly (HP:0000262)1.60655978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.85702636
2EPHA43.78697255
3MARK13.59784608
4MAP3K93.41373332
5MAP3K43.04897579
6MAP2K72.72701064
7MINK12.71321506
8DAPK22.53080237
9LATS12.40715213
10CASK2.26063897
11MYLK2.16804200
12PAK62.09223587
13NTRK22.07880037
14MAP3K121.93662056
15MAP2K41.86793442
16PRPF4B1.85356978
17PHKG21.76785869
18PHKG11.76785869
19PRKD31.74820726
20CAMKK11.69872412
21KSR21.68645677
22DAPK11.66801008
23KSR11.65034502
24MAPK131.60805728
25PLK21.57555679
26STK38L1.54981154
27CDK51.49770764
28NTRK11.44181554
29PRKCG1.41878040
30OBSCN1.38811374
31STK381.36820118
32TNIK1.36098298
33GRK51.30341984
34CDK191.27809379
35ARAF1.21668212
36MAP3K21.21459258
37PAK31.19459284
38SIK21.16465937
39RIPK41.15143872
40CAMK2B1.11633020
41CAMK2A1.09733924
42ERBB31.08062186
43CAMKK21.04914894
44SGK2231.04047520
45SGK4941.04047520
46FRK1.02262799
47SGK21.01412281
48LATS21.00218103
49PDGFRA0.97799798
50PIK3CA0.96367126
51PKN20.96237864
52CAMK10.94567294
53TRIB30.94288792
54CSNK1G20.93596308
55DYRK20.90618357
56PNCK0.89386481
57NEK20.88947993
58FGFR20.88100209
59FES0.88082777
60STK110.86128774
61CDK180.84731878
62MOS0.84363620
63DYRK1A0.82731081
64UHMK10.82677607
65TYRO30.82664071
66SGK30.82383342
67CSNK1A1L0.82306268
68CDK150.81777949
69RET0.80796294
70LMTK20.80556449
71CDK140.79574730
72MUSK0.76507772
73PTK2B0.75473106
74DAPK30.74353123
75PRKCH0.74044998
76CAMK2D0.72895423
77PAK20.71562968
78AKT30.70885877
79CDK11A0.69882580
80CDK30.68628528
81CAMK2G0.68137573
82MAP3K130.67479262
83SGK10.67420104
84TAOK10.67386672
85BMPR20.67085846
86OXSR10.65594941
87MARK20.64870908
88RAF10.63683456
89ROCK10.61481171
90PDK10.58872907
91EEF2K0.57954607
92PRKCZ0.57927386
93PINK10.57666466
94PDGFRB0.56588254
95PRKCE0.55869633
96MAPK150.55831026
97RPS6KA20.55272339
98DDR20.55034213
99ALK0.53868688
100CAMK1G0.53621345
101TIE10.52234530
102BMPR1B0.52207804
103PDPK10.51870612
104MAP3K60.50770065
105PRKAA10.50444298
106FER0.49549708
107MAP3K70.49441557
108CAMK40.47637912
109INSRR0.45816761
110EPHB20.45465249
111RPS6KB10.45444258
112NME10.45384373
113CCNB10.45351535
114PRKG10.45069126
115ROCK20.44503031
116RPS6KA30.44266500
117CSNK1D0.44014667
118CDC42BPA0.43748505
119CAMK1D0.43650578
120TNK20.43556445
121FYN0.43386358
122CSNK1G10.42986558
123SIK30.40823007
124CSNK1G30.40729670
125ICK0.40397684
126WNK30.37229226
127MAPK100.35835718
128RIPK10.33697809
129MAPK120.33540847
130NEK60.32934248
131WNK10.32484647
132PKN10.31882331
133BRAF0.31455732
134MAP3K10.30573336
135MAP2K10.29866008

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.05598237
2Nicotine addiction_Homo sapiens_hsa050333.58806717
3Synaptic vesicle cycle_Homo sapiens_hsa047213.23467217
4Circadian entrainment_Homo sapiens_hsa047132.74736937
5GABAergic synapse_Homo sapiens_hsa047272.63422331
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62781809
7Glutamatergic synapse_Homo sapiens_hsa047242.56643294
8Long-term potentiation_Homo sapiens_hsa047202.55021526
9Morphine addiction_Homo sapiens_hsa050322.48860927
10Amphetamine addiction_Homo sapiens_hsa050312.35075389
11Salivary secretion_Homo sapiens_hsa049702.14892433
12Dopaminergic synapse_Homo sapiens_hsa047282.14160410
13Insulin secretion_Homo sapiens_hsa049112.05843481
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03326819
15Cholinergic synapse_Homo sapiens_hsa047251.95562249
16Gastric acid secretion_Homo sapiens_hsa049711.89584593
17Taste transduction_Homo sapiens_hsa047421.88497208
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87199830
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74958918
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61103538
21Calcium signaling pathway_Homo sapiens_hsa040201.57908495
22Serotonergic synapse_Homo sapiens_hsa047261.56966344
23Oxytocin signaling pathway_Homo sapiens_hsa049211.54201271
24Renin secretion_Homo sapiens_hsa049241.50565091
25Cocaine addiction_Homo sapiens_hsa050301.49812054
26Long-term depression_Homo sapiens_hsa047301.49489599
27GnRH signaling pathway_Homo sapiens_hsa049121.42329528
28Collecting duct acid secretion_Homo sapiens_hsa049661.39955999
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39701354
30cAMP signaling pathway_Homo sapiens_hsa040241.36301579
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29411865
32Gap junction_Homo sapiens_hsa045401.27286276
33Axon guidance_Homo sapiens_hsa043601.23601157
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20154117
35Type II diabetes mellitus_Homo sapiens_hsa049301.17888023
36Estrogen signaling pathway_Homo sapiens_hsa049151.14477530
37ECM-receptor interaction_Homo sapiens_hsa045121.14310682
38Glioma_Homo sapiens_hsa052141.14247399
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13884734
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07826945
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07073590
42Melanogenesis_Homo sapiens_hsa049161.07051875
43Vibrio cholerae infection_Homo sapiens_hsa051101.05377971
44Phototransduction_Homo sapiens_hsa047441.03987147
45ErbB signaling pathway_Homo sapiens_hsa040121.02893560
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94267032
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.87554580
48Focal adhesion_Homo sapiens_hsa045100.87355156
49Thyroid hormone synthesis_Homo sapiens_hsa049180.85778740
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80848768
51Oocyte meiosis_Homo sapiens_hsa041140.80788848
52Cardiac muscle contraction_Homo sapiens_hsa042600.80529570
53Hippo signaling pathway_Homo sapiens_hsa043900.79416936
54Pancreatic secretion_Homo sapiens_hsa049720.79400279
55Hedgehog signaling pathway_Homo sapiens_hsa043400.79082957
56Dorso-ventral axis formation_Homo sapiens_hsa043200.77324847
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75605287
58Dilated cardiomyopathy_Homo sapiens_hsa054140.74916560
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.74402522
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73022739
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69369598
62Tight junction_Homo sapiens_hsa045300.69196581
63AMPK signaling pathway_Homo sapiens_hsa041520.68218522
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67804460
65beta-Alanine metabolism_Homo sapiens_hsa004100.67319651
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.66035852
67MAPK signaling pathway_Homo sapiens_hsa040100.65669687
68Ras signaling pathway_Homo sapiens_hsa040140.63087862
69Histidine metabolism_Homo sapiens_hsa003400.63018437
70Choline metabolism in cancer_Homo sapiens_hsa052310.62895960
71Nitrogen metabolism_Homo sapiens_hsa009100.61757472
72Protein digestion and absorption_Homo sapiens_hsa049740.61018226
73Glucagon signaling pathway_Homo sapiens_hsa049220.58410878
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58334537
75Rap1 signaling pathway_Homo sapiens_hsa040150.57761661
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56151343
77Alcoholism_Homo sapiens_hsa050340.55969721
78Butanoate metabolism_Homo sapiens_hsa006500.55141037
79Bile secretion_Homo sapiens_hsa049760.54738907
80Ovarian steroidogenesis_Homo sapiens_hsa049130.54372644
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53147318
82Endometrial cancer_Homo sapiens_hsa052130.52619266
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51583108
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51540163
85VEGF signaling pathway_Homo sapiens_hsa043700.50951488
86mTOR signaling pathway_Homo sapiens_hsa041500.49635944
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48783929
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.46916958
89Phenylalanine metabolism_Homo sapiens_hsa003600.45477522
90Type I diabetes mellitus_Homo sapiens_hsa049400.45212054
91Insulin signaling pathway_Homo sapiens_hsa049100.44365219
92Wnt signaling pathway_Homo sapiens_hsa043100.43164365
93Endocytosis_Homo sapiens_hsa041440.42207180
94PPAR signaling pathway_Homo sapiens_hsa033200.41563304
95Inositol phosphate metabolism_Homo sapiens_hsa005620.40765425
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40750540
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40084176
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39312673
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36358006
100Non-small cell lung cancer_Homo sapiens_hsa052230.36180419
101TGF-beta signaling pathway_Homo sapiens_hsa043500.35228034
102Proteoglycans in cancer_Homo sapiens_hsa052050.34836569
103Circadian rhythm_Homo sapiens_hsa047100.34576907
104ABC transporters_Homo sapiens_hsa020100.34077943
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33597435
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32539965
107Colorectal cancer_Homo sapiens_hsa052100.32338641
108Prion diseases_Homo sapiens_hsa050200.32173786
109Chemokine signaling pathway_Homo sapiens_hsa040620.31631228
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29380353
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27002978
112Renal cell carcinoma_Homo sapiens_hsa052110.26938175
113African trypanosomiasis_Homo sapiens_hsa051430.26007357
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25550724
115Alzheimers disease_Homo sapiens_hsa050100.23757023
116Melanoma_Homo sapiens_hsa052180.22929038

Most similar genes based on co-expression Upload to Enrichr

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