CLSTN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.63020772
2synaptic vesicle maturation (GO:0016188)6.62440911
3locomotory exploration behavior (GO:0035641)6.31087026
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.83981364
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.81930318
6vocalization behavior (GO:0071625)5.80452453
7synaptic vesicle exocytosis (GO:0016079)5.55974790
8glutamate secretion (GO:0014047)5.49418760
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43452606
10regulation of synaptic vesicle exocytosis (GO:2000300)5.41101692
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.31366876
12regulation of glutamate receptor signaling pathway (GO:1900449)5.08911117
13neurotransmitter secretion (GO:0007269)5.06676969
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.86969972
15gamma-aminobutyric acid transport (GO:0015812)4.86224835
16regulation of synaptic vesicle transport (GO:1902803)4.78972337
17neuronal action potential propagation (GO:0019227)4.75053179
18exploration behavior (GO:0035640)4.74255143
19protein localization to synapse (GO:0035418)4.66938273
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55712043
21neuron cell-cell adhesion (GO:0007158)4.53079349
22regulation of neuronal synaptic plasticity (GO:0048168)4.49156417
23layer formation in cerebral cortex (GO:0021819)4.44561924
24neurotransmitter-gated ion channel clustering (GO:0072578)4.43303659
25synaptic transmission, glutamatergic (GO:0035249)4.40158135
26cellular potassium ion homeostasis (GO:0030007)4.37705865
27regulation of synapse structural plasticity (GO:0051823)4.34392685
28proline transport (GO:0015824)4.34335524
29glutamate receptor signaling pathway (GO:0007215)4.30161961
30sodium ion export (GO:0071436)4.24127391
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.20568753
32neuron-neuron synaptic transmission (GO:0007270)4.16005486
33L-amino acid import (GO:0043092)4.09751104
34long-term memory (GO:0007616)4.09181298
35neurotransmitter transport (GO:0006836)4.06319449
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.06097404
37dendritic spine morphogenesis (GO:0060997)3.94704634
38activation of protein kinase A activity (GO:0034199)3.92449332
39cerebellar Purkinje cell differentiation (GO:0021702)3.92373177
40positive regulation of membrane potential (GO:0045838)3.92253863
41positive regulation of synapse maturation (GO:0090129)3.92014158
42neuromuscular process controlling posture (GO:0050884)3.89855304
43glycine transport (GO:0015816)3.88134181
44amino acid import (GO:0043090)3.84891250
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79797013
46regulation of neurotransmitter levels (GO:0001505)3.78862353
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.78212404
48neuromuscular process controlling balance (GO:0050885)3.72859257
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.69466143
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.68153305
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.62132541
52regulation of postsynaptic membrane potential (GO:0060078)3.61201103
53synaptic vesicle endocytosis (GO:0048488)3.58641323
54cellular sodium ion homeostasis (GO:0006883)3.58032956
55positive regulation of dendritic spine development (GO:0060999)3.57552639
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57197026
57regulation of neurotransmitter secretion (GO:0046928)3.56838558
58auditory behavior (GO:0031223)3.55228699
59regulation of synaptic plasticity (GO:0048167)3.54052807
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53886205
61potassium ion homeostasis (GO:0055075)3.53253612
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52104090
63transmission of nerve impulse (GO:0019226)3.48945022
64cerebellar granule cell differentiation (GO:0021707)3.48142687
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47801039
66cell communication by electrical coupling (GO:0010644)3.45312795
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44109279
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.43978639
69postsynaptic membrane organization (GO:0001941)3.43602118
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.43483258
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42559439
72negative regulation of dendrite morphogenesis (GO:0050774)3.42429404
73prepulse inhibition (GO:0060134)3.39930820
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38826837
75response to auditory stimulus (GO:0010996)3.37512140
76long-term synaptic potentiation (GO:0060291)3.37230916
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34720668
78response to pheromone (GO:0019236)3.34585193
79dendritic spine organization (GO:0097061)3.34040375
80regulation of dendritic spine morphogenesis (GO:0061001)3.32824158
81neuron recognition (GO:0008038)3.32811703
82regulation of neurotransmitter transport (GO:0051588)3.32687251
83axon ensheathment in central nervous system (GO:0032291)3.26536294
84central nervous system myelination (GO:0022010)3.26536294
85membrane depolarization during action potential (GO:0086010)3.24361880
86regulation of vesicle fusion (GO:0031338)3.23333990
87dendrite morphogenesis (GO:0048813)3.22550603
88regulation of voltage-gated calcium channel activity (GO:1901385)3.20053050
89membrane hyperpolarization (GO:0060081)3.20009581
90membrane depolarization (GO:0051899)3.17682936
91positive regulation of neurotransmitter transport (GO:0051590)3.17297026
92neuromuscular process (GO:0050905)3.14202414
93cell migration in hindbrain (GO:0021535)3.13946793
94cerebellar Purkinje cell layer development (GO:0021680)3.13071132
95positive regulation of neurotransmitter secretion (GO:0001956)3.11603016
96vesicle transport along microtubule (GO:0047496)3.11356306
97potassium ion import (GO:0010107)3.08492194
98intraspecies interaction between organisms (GO:0051703)3.07865374
99social behavior (GO:0035176)3.07865374
100regulation of ARF protein signal transduction (GO:0032012)3.07163616
101neuronal ion channel clustering (GO:0045161)3.07087973
102synapse assembly (GO:0007416)3.06747872
103regulation of synaptic transmission (GO:0050804)3.06301142
104learning (GO:0007612)3.06235128
105synaptic transmission (GO:0007268)3.06226115
106axonal fasciculation (GO:0007413)3.05817449
107positive regulation of synaptic transmission (GO:0050806)3.05763121
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05281014
109negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02089138
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02070193
111adult walking behavior (GO:0007628)3.01757312
112cell differentiation in hindbrain (GO:0021533)3.00962459
113mating behavior (GO:0007617)3.00155644
114response to histamine (GO:0034776)2.98589362
115regulation of synapse maturation (GO:0090128)2.98419312
116regulation of synaptic transmission, GABAergic (GO:0032228)2.97621221
117cell communication involved in cardiac conduction (GO:0086065)2.88117467
118establishment of mitochondrion localization (GO:0051654)2.86540609
119positive regulation of dendrite development (GO:1900006)2.85963595
120regulation of dendritic spine development (GO:0060998)2.81102542
121regulation of dendrite morphogenesis (GO:0048814)2.77246592
122dicarboxylic acid transport (GO:0006835)2.73024438
123regulation of exocytosis (GO:0017157)2.72664496
124chemosensory behavior (GO:0007635)2.72570264
125acidic amino acid transport (GO:0015800)2.71243672
126establishment of synaptic vesicle localization (GO:0097480)2.69550098
127synaptic vesicle transport (GO:0048489)2.69550098
128positive regulation of exocytosis (GO:0045921)2.68359058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98353681
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.53644161
3GBX2_23144817_ChIP-Seq_PC3_Human3.29025199
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13897687
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13853381
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02320225
7REST_21632747_ChIP-Seq_MESCs_Mouse3.00301082
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.84237330
9DROSHA_22980978_ChIP-Seq_HELA_Human2.80843454
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76386604
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76386604
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65102761
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60173019
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58439740
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.54316497
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53335692
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49638866
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45525973
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41606224
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39665089
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.38753131
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33021306
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.31797874
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30875029
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29869193
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29717799
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.18036339
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.17724994
29LXR_22292898_ChIP-Seq_THP-1_Human2.10207572
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06613292
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05287722
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04997814
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.83060800
34AR_21572438_ChIP-Seq_LNCaP_Human1.74803282
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61465620
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58695846
37KDM2B_26808549_Chip-Seq_DND41_Human1.57628045
38SMAD4_21799915_ChIP-Seq_A2780_Human1.53853711
39* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51346240
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50725277
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50711503
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.50060721
43* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45107173
44TAF15_26573619_Chip-Seq_HEK293_Human1.43701751
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41059848
46ZNF274_21170338_ChIP-Seq_K562_Hela1.37974814
47SMC4_20622854_ChIP-Seq_HELA_Human1.37851745
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35631777
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.33106113
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33004158
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.32663976
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30513622
53TCF7_22412390_ChIP-Seq_EML_Mouse1.29205492
54AR_19668381_ChIP-Seq_PC3_Human1.28131044
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27960466
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27669949
57KDM2B_26808549_Chip-Seq_K562_Human1.25936233
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.24050687
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23803425
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23252835
61CREB1_26743006_Chip-Seq_LNCaP_Human1.23159507
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22483612
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19830508
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19469082
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18136155
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17025845
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16923813
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16062440
69P68_20966046_ChIP-Seq_HELA_Human1.15994995
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15690795
71STAT3_23295773_ChIP-Seq_U87_Human1.15089760
72AR_25329375_ChIP-Seq_VCAP_Human1.14883530
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.14649604
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13752801
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13646911
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12108947
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11099971
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11020132
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10646371
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.09161940
81P300_19829295_ChIP-Seq_ESCs_Human1.07482856
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.06783411
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06588382
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05998378
85OCT4_19829295_ChIP-Seq_ESCs_Human1.05897771
86RACK7_27058665_Chip-Seq_MCF-7_Human1.05789148
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05230924
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02874544
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02859633
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01879062
91TCF4_23295773_ChIP-Seq_U87_Human1.01565553
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01101207
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97837728
94SA1_27219007_Chip-Seq_ERYTHROID_Human0.97451049
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.97076637
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96729500
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.95569342
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.95560550
99* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95297022
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94882502
101TET1_21490601_ChIP-Seq_MESCs_Mouse0.94473825
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94292980
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94100990
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94045182
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93814661
106* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93434782
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93406765
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93294362
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92231422
110RNF2_27304074_Chip-Seq_NSC_Mouse0.91373349
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.91365619
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91311954
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.91255383
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91209744
115AHR_22903824_ChIP-Seq_MCF-7_Human0.91082441
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.90643921
117IGF1R_20145208_ChIP-Seq_DFB_Human0.90093994
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89740813
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.89737922
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89234644
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89166828
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.88542011
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88443446
124DPY_21335234_ChIP-Seq_ESCs_Mouse0.88331570
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86395113
126CTCF_27219007_Chip-Seq_Bcells_Human0.85961825
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.85952413
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85906837
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.85835489
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85702313
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85296544
132RXR_22108803_ChIP-Seq_LS180_Human0.84829763
133RUNX2_22187159_ChIP-Seq_PCA_Human0.84539819
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84328494
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.83852881
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83002065
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.82243712
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82035599
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81588794
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81489963
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80791378
142KLF4_19829295_ChIP-Seq_ESCs_Human0.80464829
143MYC_19915707_ChIP-ChIP_AK7_Human0.79916263
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79535276
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79281753
146TP53_16413492_ChIP-PET_HCT116_Human0.78737554
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.78149423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.70302018
2MP0003880_abnormal_central_pattern4.53777413
3MP0003635_abnormal_synaptic_transmissio4.32572538
4MP0009046_muscle_twitch3.65572271
5MP0004270_analgesia3.56894194
6MP0009745_abnormal_behavioral_response3.55655047
7MP0002064_seizures3.35692084
8MP0002063_abnormal_learning/memory/cond3.35685528
9MP0005423_abnormal_somatic_nervous3.14709371
10MP0001968_abnormal_touch/_nociception2.92282663
11MP0002822_catalepsy2.88138594
12MP0002572_abnormal_emotion/affect_behav2.82026581
13MP0002272_abnormal_nervous_system2.72568308
14MP0002734_abnormal_mechanical_nocicepti2.71451513
15MP0001486_abnormal_startle_reflex2.60099403
16MP0001501_abnormal_sleep_pattern2.38398954
17MP0008569_lethality_at_weaning2.21677353
18MP0002736_abnormal_nociception_after2.18835987
19MP0009780_abnormal_chondrocyte_physiolo2.11915579
20MP0001440_abnormal_grooming_behavior2.11293996
21MP0002735_abnormal_chemical_nociception2.05560904
22MP0002733_abnormal_thermal_nociception2.05214183
23MP0002067_abnormal_sensory_capabilities2.03871266
24MP0001970_abnormal_pain_threshold1.98058903
25MP0003329_amyloid_beta_deposits1.93626410
26MP0002909_abnormal_adrenal_gland1.88226676
27MP0004811_abnormal_neuron_physiology1.83980737
28MP0002184_abnormal_innervation1.82944490
29MP0005386_behavior/neurological_phenoty1.78983426
30MP0004924_abnormal_behavior1.78983426
31MP0002557_abnormal_social/conspecific_i1.78007056
32MP0004858_abnormal_nervous_system1.75971233
33MP0005646_abnormal_pituitary_gland1.69083014
34MP0001348_abnormal_lacrimal_gland1.66648947
35MP0003879_abnormal_hair_cell1.63666104
36MP0004885_abnormal_endolymph1.63633342
37MP0003787_abnormal_imprinting1.63398848
38MP0000955_abnormal_spinal_cord1.60612017
39MP0000778_abnormal_nervous_system1.58484568
40MP0002066_abnormal_motor_capabilities/c1.49377240
41MP0005409_darkened_coat_color1.46614965
42MP0004142_abnormal_muscle_tone1.46235718
43MP0003633_abnormal_nervous_system1.43716040
44MP0001984_abnormal_olfaction1.40705312
45MP0002882_abnormal_neuron_morphology1.40139481
46MP0005645_abnormal_hypothalamus_physiol1.38389100
47MP0006276_abnormal_autonomic_nervous1.37167854
48MP0003122_maternal_imprinting1.35641433
49MP0001502_abnormal_circadian_rhythm1.24453395
50MP0003631_nervous_system_phenotype1.23122683
51MP0000566_synostosis1.17913999
52MP0008872_abnormal_physiological_respon1.14759058
53MP0002152_abnormal_brain_morphology1.11681042
54MP0001529_abnormal_vocalization1.11452772
55MP0000013_abnormal_adipose_tissue1.10631308
56MP0001905_abnormal_dopamine_level1.06435157
57MP0003283_abnormal_digestive_organ1.06284909
58MP0004145_abnormal_muscle_electrophysio1.05725386
59MP0003690_abnormal_glial_cell1.02547279
60MP0002229_neurodegeneration1.02458308
61MP0008961_abnormal_basal_metabolism1.00305136
62MP0000569_abnormal_digit_pigmentation0.99812430
63MP0002069_abnormal_eating/drinking_beha0.97916961
64MP0003632_abnormal_nervous_system0.97645641
65MP0000751_myopathy0.96981678
66MP0002089_abnormal_postnatal_growth/wei0.94332515
67MP0008874_decreased_physiological_sensi0.92804229
68MP0001177_atelectasis0.91472210
69MP0002249_abnormal_larynx_morphology0.91017772
70MP0005535_abnormal_body_temperature0.89390648
71MP0000604_amyloidosis0.86383284
72MP0005551_abnormal_eye_electrophysiolog0.86003448
73MP0001188_hyperpigmentation0.84988227
74MP0003121_genomic_imprinting0.84903888
75MP0003634_abnormal_glial_cell0.84833297
76MP0003075_altered_response_to0.84609184
77MP0004233_abnormal_muscle_weight0.81361231
78MP0004742_abnormal_vestibular_system0.80522245
79MP0000920_abnormal_myelination0.80427835
80MP0001346_abnormal_lacrimal_gland0.79950293
81MP0005394_taste/olfaction_phenotype0.79922417
82MP0005499_abnormal_olfactory_system0.79922417
83MP0004085_abnormal_heartbeat0.79242936
84MP0003183_abnormal_peptide_metabolism0.77570298
85MP0001963_abnormal_hearing_physiology0.74112730
86MP0008260_abnormal_autophagy0.73004183
87MP0005167_abnormal_blood-brain_barrier0.70959622
88MP0004043_abnormal_pH_regulation0.70820960
89MP0002090_abnormal_vision0.70257870
90MP0003705_abnormal_hypodermis_morpholog0.69262774
91MP0003172_abnormal_lysosome_physiology0.68945314
92MP0004215_abnormal_myocardial_fiber0.68613678
93MP0000579_abnormal_nail_morphology0.68323555
94MP0002752_abnormal_somatic_nervous0.67717905
95MP0003137_abnormal_impulse_conducting0.67350673
96MP0010386_abnormal_urinary_bladder0.67245544
97MP0000631_abnormal_neuroendocrine_gland0.66910889
98MP0005623_abnormal_meninges_morphology0.64595871
99MP0001849_ear_inflammation0.59713448
100MP0002837_dystrophic_cardiac_calcinosis0.57923676
101MP0010769_abnormal_survival0.57647887
102MP0003861_abnormal_nervous_system0.57446757
103MP0004484_altered_response_of0.56574220
104MP0001664_abnormal_digestion0.56546393
105MP0001299_abnormal_eye_distance/0.56496866
106MP0003123_paternal_imprinting0.55296647
107MP0010770_preweaning_lethality0.55157903
108MP0002082_postnatal_lethality0.55157903
109MP0001943_abnormal_respiration0.54327307
110MP0002638_abnormal_pupillary_reflex0.54309007
111MP0010768_mortality/aging0.54078330
112MP0004130_abnormal_muscle_cell0.53918922
113MP0001485_abnormal_pinna_reflex0.53647475
114MP0003045_fibrosis0.53112192
115MP0000639_abnormal_adrenal_gland0.51174380
116MP0003956_abnormal_body_size0.48753757
117MP0001986_abnormal_taste_sensitivity0.48538127
118MP0000681_abnormal_thyroid_gland0.46101392
119MP0010329_abnormal_lipoprotein_level0.46057095
120MP0001731_abnormal_postnatal_growth0.45643871
121MP0003938_abnormal_ear_development0.45264201
122MP0002873_normal_phenotype0.44886572
123MP0004510_myositis0.44064144
124MP0002169_no_abnormal_phenotype0.43658199

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.35277798
2Myokymia (HP:0002411)6.93087308
3Focal seizures (HP:0007359)5.70442363
4Visual hallucinations (HP:0002367)5.68353164
5Progressive cerebellar ataxia (HP:0002073)4.76897745
6Atonic seizures (HP:0010819)4.71731197
7Epileptic encephalopathy (HP:0200134)4.71422358
8Action tremor (HP:0002345)4.51723395
9Febrile seizures (HP:0002373)4.47326190
10Absence seizures (HP:0002121)4.21929948
11Generalized tonic-clonic seizures (HP:0002069)3.93244805
12Dialeptic seizures (HP:0011146)3.77820094
13Supranuclear gaze palsy (HP:0000605)3.74635202
14Ankle clonus (HP:0011448)3.71609759
15Gaze-evoked nystagmus (HP:0000640)3.70412343
16Broad-based gait (HP:0002136)3.59567561
17Dysdiadochokinesis (HP:0002075)3.59204223
18Poor eye contact (HP:0000817)3.54246627
19Mutism (HP:0002300)3.51990697
20Depression (HP:0000716)3.51110905
21Abnormality of the lower motor neuron (HP:0002366)3.42019655
22Impaired vibration sensation in the lower limbs (HP:0002166)3.35754447
23Postural instability (HP:0002172)3.30107829
24Abnormal social behavior (HP:0012433)3.29227107
25Impaired social interactions (HP:0000735)3.29227107
26Abnormal eating behavior (HP:0100738)3.27121346
27Truncal ataxia (HP:0002078)3.21146551
28Dysmetria (HP:0001310)3.20539538
29Urinary bladder sphincter dysfunction (HP:0002839)3.17553436
30Hemiplegia (HP:0002301)3.14627278
31Anxiety (HP:0000739)3.11698527
32Impaired smooth pursuit (HP:0007772)3.08402228
33Dysmetric saccades (HP:0000641)3.05065734
34Papilledema (HP:0001085)2.99841655
35Genetic anticipation (HP:0003743)2.99439429
36Intention tremor (HP:0002080)2.99349210
37Scanning speech (HP:0002168)2.91964431
38Abnormality of binocular vision (HP:0011514)2.89449767
39Diplopia (HP:0000651)2.89449767
40Torticollis (HP:0000473)2.81697086
41Hemiparesis (HP:0001269)2.81603793
42Abnormality of ocular smooth pursuit (HP:0000617)2.81063894
43Hyperventilation (HP:0002883)2.79715769
44Progressive inability to walk (HP:0002505)2.77673556
45Deep venous thrombosis (HP:0002625)2.77028565
46Akinesia (HP:0002304)2.71917077
47Ventricular fibrillation (HP:0001663)2.70073969
48Bradykinesia (HP:0002067)2.69795989
49Spastic gait (HP:0002064)2.69662333
50Urinary urgency (HP:0000012)2.67510024
51Focal dystonia (HP:0004373)2.62129163
52Bronchomalacia (HP:0002780)2.60777325
53Status epilepticus (HP:0002133)2.60686795
54Pheochromocytoma (HP:0002666)2.55864076
55Drooling (HP:0002307)2.52427983
56Excessive salivation (HP:0003781)2.52427983
57Sleep apnea (HP:0010535)2.51047549
58Annular pancreas (HP:0001734)2.46231048
59Limb dystonia (HP:0002451)2.44431837
60Amblyopia (HP:0000646)2.44148644
61Upper limb amyotrophy (HP:0009129)2.40010938
62Distal upper limb amyotrophy (HP:0007149)2.40010938
63Peripheral hypomyelination (HP:0007182)2.38246390
64Apathy (HP:0000741)2.34618177
65Craniofacial dystonia (HP:0012179)2.34435802
66Abnormality of the corticospinal tract (HP:0002492)2.34152594
67Epileptiform EEG discharges (HP:0011182)2.33422265
68Stereotypic behavior (HP:0000733)2.32812574
69Neurofibrillary tangles (HP:0002185)2.30991497
70Impaired vibratory sensation (HP:0002495)2.30840739
71Hand muscle atrophy (HP:0009130)2.30786403
72Amyotrophic lateral sclerosis (HP:0007354)2.29538810
73Polyphagia (HP:0002591)2.28531849
74EEG with generalized epileptiform discharges (HP:0011198)2.28422570
75Fetal akinesia sequence (HP:0001989)2.28317179
76Spinal canal stenosis (HP:0003416)2.27940731
77Cerebral inclusion bodies (HP:0100314)2.25241060
78Tetraplegia (HP:0002445)2.25139689
79Agitation (HP:0000713)2.22762158
80Cerebral hypomyelination (HP:0006808)2.20902518
81Hypsarrhythmia (HP:0002521)2.20634887
82Abnormality of saccadic eye movements (HP:0000570)2.20604171
83Insomnia (HP:0100785)2.20236779
84Lower limb muscle weakness (HP:0007340)2.19870206
85Cerebral aneurysm (HP:0004944)2.19152042
86Neuroendocrine neoplasm (HP:0100634)2.17834998
87Megalencephaly (HP:0001355)2.16253833
88Pointed chin (HP:0000307)2.16119347
89Neuronal loss in central nervous system (HP:0002529)2.15243253
90Clonus (HP:0002169)2.14822405
91Lower limb asymmetry (HP:0100559)2.11383389
92Resting tremor (HP:0002322)2.10953162
93Gait ataxia (HP:0002066)2.10224825
94Lower limb amyotrophy (HP:0007210)2.10085981
95Turricephaly (HP:0000262)2.08020474
96Diminished motivation (HP:0000745)2.07535273
97Generalized myoclonic seizures (HP:0002123)2.06905743
98Termporal pattern (HP:0011008)2.05987569
99Insidious onset (HP:0003587)2.05987569
100Rapidly progressive (HP:0003678)2.04587020
101Hyperacusis (HP:0010780)2.02077805
102Absent speech (HP:0001344)2.01977640
103Bundle branch block (HP:0011710)2.00351149
104Inability to walk (HP:0002540)1.99180393
105Rigidity (HP:0002063)1.97873352
106Postural tremor (HP:0002174)1.96189118
107Incomplete penetrance (HP:0003829)1.95226360
108Aplasia involving bones of the upper limbs (HP:0009823)1.93942837
109Aplasia of the phalanges of the hand (HP:0009802)1.93942837
110Aplasia involving bones of the extremities (HP:0009825)1.93942837
111Neoplasm of the peripheral nervous system (HP:0100007)1.91458257
112Failure to thrive in infancy (HP:0001531)1.91235096
113Psychosis (HP:0000709)1.89732974
114Hammertoe (HP:0001765)1.89536009
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83431120
116Growth hormone excess (HP:0000845)1.81880656
117Blue irides (HP:0000635)1.81854065
118Shallow orbits (HP:0000586)1.79903602
119Limb ataxia (HP:0002070)1.79547433
120Abnormal EKG (HP:0003115)1.78591929
121Obstructive sleep apnea (HP:0002870)1.77457303
122Morphological abnormality of the pyramidal tract (HP:0002062)1.76717994
123Horizontal nystagmus (HP:0000666)1.74886368
124Delusions (HP:0000746)1.73610750
125Distal sensory impairment (HP:0002936)1.65087756
126Spastic tetraparesis (HP:0001285)1.63334989
127Slow saccadic eye movements (HP:0000514)1.63069858
128Onion bulb formation (HP:0003383)1.60890204
129Slow progression (HP:0003677)1.60650431
130Alacrima (HP:0000522)1.58606227
131Hypercortisolism (HP:0001578)1.56839336
132Memory impairment (HP:0002354)1.55977467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.28997831
2MAP3K94.01064757
3EPHA43.61350144
4MARK13.35079484
5MAP3K43.10570673
6MINK12.78627275
7DAPK22.66503168
8MAP2K72.53003875
9NTRK22.46014427
10PAK62.41319689
11CAMKK12.12581557
12PRKD32.07041746
13MAP2K42.03477854
14MAP3K121.91261167
15KSR21.88653962
16NTRK11.88472253
17TRIB31.68202839
18CDK191.67050392
19STK381.65648006
20DAPK11.57614159
21CDK51.57287662
22CASK1.55641155
23GRK51.49092541
24FGFR41.44033908
25PLK21.41019577
26CAMKK21.40716269
27PRPF4B1.39187086
28RIPK41.35023307
29KSR11.34334490
30PRKCG1.30050308
31TYRO31.27960487
32MAPK131.22544244
33SIK21.21043024
34UHMK11.20726323
35TNIK1.17696056
36PHKG11.16222560
37PHKG21.16222560
38TAOK11.10911812
39ALK1.10801412
40FES1.08364094
41LATS21.07906245
42PRKCH1.04819275
43ARAF1.03388868
44STK111.00971611
45CDK151.00044005
46SGK2230.99747674
47SGK4940.99747674
48CAMK10.99600246
49CDK180.99558839
50RIPK10.98650386
51PNCK0.98273766
52PINK10.95944294
53SIK10.95269336
54MAP3K20.94965736
55NEK10.91961459
56CDK140.91908514
57CDK120.89230955
58CDK11A0.87393315
59CAMK2A0.86147926
60MAPK120.85823204
61EEF2K0.85102505
62SGK30.84451334
63SGK20.84151172
64LMTK20.83840919
65RET0.83741321
66ERN10.81010044
67MAP3K130.80736727
68FGFR20.79388915
69FGFR30.77609472
70OXSR10.74515132
71MAP3K110.74406709
72TNK20.73341544
73SCYL20.72529187
74WNK10.69844352
75CAMK2B0.69830086
76PDGFRA0.69747546
77PDK10.68906072
78DYRK1A0.68709333
79MARK20.68460281
80PAK30.65570424
81CSNK1G20.65523098
82SGK10.65286330
83PDPK10.60796009
84BRSK10.59014060
85RAF10.58144114
86CDC42BPA0.58124705
87RPS6KA30.55945054
88ERBB20.54136555
89JAK10.53322675
90TESK10.52531920
91CAMK40.52499733
92CAMK1G0.51446719
93CAMK2G0.50804864
94MAP3K10.50752171
95NEK60.50426202
96PRKCZ0.48269497
97CCNB10.47331975
98MAPK100.47233456
99FYN0.46848267
100DYRK1B0.44280129
101DAPK30.42115519
102PTK2B0.41787387
103MAP3K60.41455234
104CAMK2D0.41450804
105AKT30.41390143
106ROCK20.40259562
107PRKCE0.40002927
108SRC0.39673554
109BRAF0.39639760
110SMG10.38950382
111PDK30.38433789
112PDK40.38433789
113MAP3K70.38354206
114MAPK80.37369820
115WNK30.37161211
116PKN10.37074045
117PRKD20.36602980
118PKN20.33367403
119JAK20.33346162
120RPS6KA20.32867419
121PRKCB0.32840712
122BMPR20.31761073
123FER0.30265627
124ICK0.29745759
125MAP2K60.28955391

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.89181140
2Synaptic vesicle cycle_Homo sapiens_hsa047213.61774538
3GABAergic synapse_Homo sapiens_hsa047272.92205777
4Olfactory transduction_Homo sapiens_hsa047402.73115871
5Circadian entrainment_Homo sapiens_hsa047132.68957833
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67493224
7Glutamatergic synapse_Homo sapiens_hsa047242.60580776
8Long-term potentiation_Homo sapiens_hsa047202.58008512
9Morphine addiction_Homo sapiens_hsa050322.54713565
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38166358
11Amphetamine addiction_Homo sapiens_hsa050312.32693714
12Salivary secretion_Homo sapiens_hsa049702.18829133
13Dopaminergic synapse_Homo sapiens_hsa047282.09161745
14Insulin secretion_Homo sapiens_hsa049112.00216849
15Gastric acid secretion_Homo sapiens_hsa049711.92423906
16Cholinergic synapse_Homo sapiens_hsa047251.83991306
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83411217
18Taste transduction_Homo sapiens_hsa047421.78034585
19Long-term depression_Homo sapiens_hsa047301.75287917
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67399086
21Cocaine addiction_Homo sapiens_hsa050301.59304654
22Oxytocin signaling pathway_Homo sapiens_hsa049211.55099850
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55084154
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54367811
25Renin secretion_Homo sapiens_hsa049241.53595447
26Calcium signaling pathway_Homo sapiens_hsa040201.51600780
27Serotonergic synapse_Homo sapiens_hsa047261.48422090
28Collecting duct acid secretion_Homo sapiens_hsa049661.44890728
29Nitrogen metabolism_Homo sapiens_hsa009101.44713522
30GnRH signaling pathway_Homo sapiens_hsa049121.36263858
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35861188
32Gap junction_Homo sapiens_hsa045401.32771520
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28390779
34Type II diabetes mellitus_Homo sapiens_hsa049301.27568750
35cAMP signaling pathway_Homo sapiens_hsa040241.23903870
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16933013
37Estrogen signaling pathway_Homo sapiens_hsa049151.15637720
38Vitamin B6 metabolism_Homo sapiens_hsa007501.07334833
39Glioma_Homo sapiens_hsa052141.03584960
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01474348
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94468751
42ErbB signaling pathway_Homo sapiens_hsa040120.94403936
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92577505
44Melanogenesis_Homo sapiens_hsa049160.92076187
45Vibrio cholerae infection_Homo sapiens_hsa051100.91666609
46Axon guidance_Homo sapiens_hsa043600.90620618
47Cardiac muscle contraction_Homo sapiens_hsa042600.89262169
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88569020
49Oocyte meiosis_Homo sapiens_hsa041140.87065820
50Pancreatic secretion_Homo sapiens_hsa049720.84317696
51Thyroid hormone synthesis_Homo sapiens_hsa049180.82498290
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.82404274
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.81340579
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81101089
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77059445
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73987068
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72239473
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71170114
59Dorso-ventral axis formation_Homo sapiens_hsa043200.71106806
60Dilated cardiomyopathy_Homo sapiens_hsa054140.69970654
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69156670
62Bile secretion_Homo sapiens_hsa049760.68100848
63MAPK signaling pathway_Homo sapiens_hsa040100.66133655
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65085714
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64818575
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62788015
67Type I diabetes mellitus_Homo sapiens_hsa049400.62638854
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62280973
69Choline metabolism in cancer_Homo sapiens_hsa052310.61642379
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.59901866
71Phototransduction_Homo sapiens_hsa047440.58359141
72Glucagon signaling pathway_Homo sapiens_hsa049220.57961062
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.56252389
74mTOR signaling pathway_Homo sapiens_hsa041500.55843765
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54178602
76Inositol phosphate metabolism_Homo sapiens_hsa005620.52721110
77Endocytosis_Homo sapiens_hsa041440.50468741
78Alcoholism_Homo sapiens_hsa050340.49415478
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49195187
80Notch signaling pathway_Homo sapiens_hsa043300.48914904
81AMPK signaling pathway_Homo sapiens_hsa041520.48554545
82Rap1 signaling pathway_Homo sapiens_hsa040150.47075365
83Ras signaling pathway_Homo sapiens_hsa040140.46468978
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45938321
85VEGF signaling pathway_Homo sapiens_hsa043700.45206438
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44980613
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44229881
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43537417
89Insulin signaling pathway_Homo sapiens_hsa049100.43075862
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42198156
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.41874888
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41463601
93Endometrial cancer_Homo sapiens_hsa052130.41435375
94Circadian rhythm_Homo sapiens_hsa047100.41018147
95Histidine metabolism_Homo sapiens_hsa003400.40807533
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40274307
97Complement and coagulation cascades_Homo sapiens_hsa046100.40064685
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39581552
99HIF-1 signaling pathway_Homo sapiens_hsa040660.39005041
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.38787726
101Prion diseases_Homo sapiens_hsa050200.38121084
102Prolactin signaling pathway_Homo sapiens_hsa049170.37633155
103Non-small cell lung cancer_Homo sapiens_hsa052230.37363715
104Ovarian steroidogenesis_Homo sapiens_hsa049130.36545420
105Arginine biosynthesis_Homo sapiens_hsa002200.36143076
106Wnt signaling pathway_Homo sapiens_hsa043100.36035799
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35549176
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35117915
109Butanoate metabolism_Homo sapiens_hsa006500.34179967
110Arginine and proline metabolism_Homo sapiens_hsa003300.34080871
111Fatty acid biosynthesis_Homo sapiens_hsa000610.33585314
112Renal cell carcinoma_Homo sapiens_hsa052110.32253984
113Chronic myeloid leukemia_Homo sapiens_hsa052200.32036680
114ABC transporters_Homo sapiens_hsa020100.31822419
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30275870
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.30093286
117Chemokine signaling pathway_Homo sapiens_hsa040620.28218178
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28058369

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