CLTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.69584811
2desmosome organization (GO:0002934)6.48458673
3synaptic vesicle maturation (GO:0016188)5.07337592
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79945332
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74808488
6regulation of water loss via skin (GO:0033561)4.69850986
7protein localization to endosome (GO:0036010)4.65825001
8establishment of skin barrier (GO:0061436)4.60523872
9synaptic vesicle exocytosis (GO:0016079)4.53110592
10glutamate secretion (GO:0014047)4.26789088
11regulation of synaptic vesicle exocytosis (GO:2000300)4.23455726
12cell-substrate junction assembly (GO:0007044)4.22305352
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.03221714
14keratinization (GO:0031424)3.98225385
15locomotory exploration behavior (GO:0035641)3.94347665
16barbed-end actin filament capping (GO:0051016)3.84545858
17vocalization behavior (GO:0071625)3.83122879
18regulation of synaptic vesicle transport (GO:1902803)3.76230508
19cellular potassium ion homeostasis (GO:0030007)3.67814201
20NADH metabolic process (GO:0006734)3.66150736
21neurotransmitter secretion (GO:0007269)3.65010596
22neuronal action potential propagation (GO:0019227)3.64036424
23skin morphogenesis (GO:0043589)3.60668320
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51227828
25Golgi transport vesicle coating (GO:0048200)3.48160497
26COPI coating of Golgi vesicle (GO:0048205)3.48160497
27sodium ion export (GO:0071436)3.45227014
28protein localization to synapse (GO:0035418)3.44896624
29activation of protein kinase A activity (GO:0034199)3.41904544
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41293489
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.39410344
32multicellular organismal water homeostasis (GO:0050891)3.37720704
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36563262
34regulation of early endosome to late endosome transport (GO:2000641)3.35691950
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34384334
36cell-substrate adherens junction assembly (GO:0007045)3.31306546
37focal adhesion assembly (GO:0048041)3.31306546
38layer formation in cerebral cortex (GO:0021819)3.31220535
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28758771
40regulation of synapse structural plasticity (GO:0051823)3.26293421
41neuromuscular process controlling posture (GO:0050884)3.25917233
42protein retention in ER lumen (GO:0006621)3.24284447
43adherens junction assembly (GO:0034333)3.19896574
44keratinocyte proliferation (GO:0043616)3.17743977
45epithelial cell-cell adhesion (GO:0090136)3.13253122
46regulation of neuronal synaptic plasticity (GO:0048168)3.10457750
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08968831
48positive regulation of Cdc42 GTPase activity (GO:0043089)3.08006146
49proline transport (GO:0015824)3.07721089
50cell communication by electrical coupling (GO:0010644)3.07111587
51regulation of vesicle fusion (GO:0031338)3.06642373
52exploration behavior (GO:0035640)3.06393111
53regulation of glutamate receptor signaling pathway (GO:1900449)3.05492898
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01811113
55cell communication involved in cardiac conduction (GO:0086065)2.99963074
56neurotransmitter transport (GO:0006836)2.99156837
57regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93462532
58neuron cell-cell adhesion (GO:0007158)2.90482656
59gamma-aminobutyric acid transport (GO:0015812)2.89859839
60positive regulation of potassium ion transmembrane transport (GO:1901381)2.87590581
61glycine transport (GO:0015816)2.87033246
62adhesion of symbiont to host cell (GO:0044650)2.86924687
63virion attachment to host cell (GO:0019062)2.86924687
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84179802
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83723336
66response to pheromone (GO:0019236)2.80462549
67positive regulation of vesicle fusion (GO:0031340)2.78712043
68endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.78677865
69potassium ion homeostasis (GO:0055075)2.76497993
70GDP-mannose metabolic process (GO:0019673)2.76111312
71stress fiber assembly (GO:0043149)2.74778542
72positive regulation of synapse maturation (GO:0090129)2.73465347
73regulation of neurotransmitter levels (GO:0001505)2.73407016
74positive regulation of pseudopodium assembly (GO:0031274)2.72560406
75axon cargo transport (GO:0008088)2.72030908
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71698849
77regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70409312
78synaptic vesicle endocytosis (GO:0048488)2.69866002
79adhesion of symbiont to host (GO:0044406)2.69600936
80hypotonic response (GO:0006971)2.68313211
81membrane depolarization during action potential (GO:0086010)2.67977054
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.67713257
83negative regulation of microtubule polymerization (GO:0031115)2.67457716
84regulation of pseudopodium assembly (GO:0031272)2.67221800
85neuromuscular process controlling balance (GO:0050885)2.67190312
86negative regulation of cell size (GO:0045792)2.66487905
87positive regulation of potassium ion transport (GO:0043268)2.65903326
88cerebellar Purkinje cell layer development (GO:0021680)2.65644940
89neurotransmitter-gated ion channel clustering (GO:0072578)2.65136602
90cerebellar Purkinje cell differentiation (GO:0021702)2.64666789
91actin filament depolymerization (GO:0030042)2.64534998
92vesicle transport along microtubule (GO:0047496)2.64365716
93synaptic transmission, glutamatergic (GO:0035249)2.64078897
94water homeostasis (GO:0030104)2.63613629
95cell migration in hindbrain (GO:0021535)2.63088957
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63034495
97regulation of neurotransmitter secretion (GO:0046928)2.62858928
98activation of MAPKKK activity (GO:0000185)2.61843673
99positive regulation of epidermis development (GO:0045684)2.60553593
100neuron-neuron synaptic transmission (GO:0007270)2.60241677
101organelle transport along microtubule (GO:0072384)2.60197591
102regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60028765
103potassium ion import (GO:0010107)2.59796706
104membrane repolarization (GO:0086009)2.58143483
105regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57637036
106mating behavior (GO:0007617)2.57398780
107activation of Rac GTPase activity (GO:0032863)2.57055287
108vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55637986
109innervation (GO:0060384)2.53805728
110detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.53789065
111detection of temperature stimulus involved in sensory perception (GO:0050961)2.53789065
112glutamate receptor signaling pathway (GO:0007215)2.53738930
113chemosensory behavior (GO:0007635)2.53000620
114regulation of necrotic cell death (GO:0010939)2.52586597
115intermediate filament organization (GO:0045109)2.52268182
116regulation of voltage-gated calcium channel activity (GO:1901385)2.51423409
117protein maturation by protein folding (GO:0022417)2.51323111
118dendrite morphogenesis (GO:0048813)2.51249338
119endothelial cell chemotaxis (GO:0035767)2.50831860
120apoptotic process involved in morphogenesis (GO:0060561)2.50731885
121cellular sodium ion homeostasis (GO:0006883)2.50306586
122positive regulation of membrane potential (GO:0045838)2.50196564
123positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.50146145
124nucleoside diphosphate biosynthetic process (GO:0009133)2.49407500
125surfactant homeostasis (GO:0043129)2.49120674
126protein targeting to plasma membrane (GO:0072661)2.48030121
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47510620
128cellular copper ion homeostasis (GO:0006878)2.46910657
129dendritic spine morphogenesis (GO:0060997)2.46616604
130regulation of synaptic plasticity (GO:0048167)2.46385038
131plasma membrane repair (GO:0001778)2.46093210
132positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45416778
133long-term memory (GO:0007616)2.45402438
134regulation of neurotransmitter transport (GO:0051588)2.45344122
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45296743
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.44983196
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.43845498
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.43845387
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42914047
140actin filament bundle organization (GO:0061572)2.42850723
141actin filament bundle assembly (GO:0051017)2.42850723
142detection of calcium ion (GO:0005513)2.42493666
143positive regulation of keratinocyte differentiation (GO:0045618)2.41665097
144negative regulation of dendrite morphogenesis (GO:0050774)2.41411928
145endocytic recycling (GO:0032456)2.41355388
146membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.40804334
147pinocytosis (GO:0006907)2.40735697
148regulation of calcium ion transmembrane transporter activity (GO:1901019)2.40473499
149regulation of calcium ion transmembrane transport (GO:1903169)2.40473499
150membrane tubulation (GO:0097320)2.40018426
151positive regulation of receptor recycling (GO:0001921)2.39356544
152positive regulation of epidermal cell differentiation (GO:0045606)2.39031084
153neuron recognition (GO:0008038)2.38806672
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38801833
155calcium-mediated signaling using intracellular calcium source (GO:0035584)2.38291147
156regulation of glucocorticoid metabolic process (GO:0031943)2.38066231
157positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.37754757
158regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.37609680
159atrioventricular valve morphogenesis (GO:0003181)2.37200493
160regulation of calcium ion-dependent exocytosis (GO:0017158)2.36432613
161regulation of postsynaptic membrane potential (GO:0060078)2.36331151
162negative regulation of erythrocyte differentiation (GO:0045647)2.34510643
163detection of temperature stimulus (GO:0016048)2.33983435
164gamma-aminobutyric acid signaling pathway (GO:0007214)2.33897956
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.33060464
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.32891545
167cellular response to glucagon stimulus (GO:0071377)2.32600283
168cell adhesion mediated by integrin (GO:0033627)2.32164078
169keratinocyte differentiation (GO:0030216)2.32111823
170prostaglandin biosynthetic process (GO:0001516)2.28779009
171prostanoid biosynthetic process (GO:0046457)2.28779009
172establishment of protein localization to plasma membrane (GO:0090002)2.26816699
173peptide cross-linking (GO:0018149)2.26587335
174semaphorin-plexin signaling pathway (GO:0071526)2.24994499
175positive regulation of protein dephosphorylation (GO:0035307)2.23453513
176regulation of cholesterol homeostasis (GO:2000188)2.21944494
177gap junction assembly (GO:0016264)2.20394098
178peptidyl-proline hydroxylation (GO:0019511)2.20354127
179negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.19858589
180actin-myosin filament sliding (GO:0033275)2.18159797
181muscle filament sliding (GO:0030049)2.18159797
182regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.18047055
183regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.17714957
184regulation of apoptotic process involved in morphogenesis (GO:1902337)2.15329230
185cardiac muscle contraction (GO:0060048)2.14810158
186mitotic nuclear envelope reassembly (GO:0007084)2.13509517
187nuclear envelope reassembly (GO:0031468)2.13509517
188negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.13312210
189negative regulation of fatty acid transport (GO:2000192)2.13196845
190cell-cell junction maintenance (GO:0045217)2.12098243
191positive regulation of blood vessel endothelial cell migration (GO:0043536)2.11406129
192positive regulation of protein export from nucleus (GO:0046827)2.10701326
193planar cell polarity pathway involved in neural tube closure (GO:0090179)2.10322188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.82503615
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12972298
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68468669
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65326487
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53386306
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.50339691
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45211115
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43019703
9RACK7_27058665_Chip-Seq_MCF-7_Human2.39444235
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38742552
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38338771
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35781921
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35781921
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27065453
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26585192
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.16710431
17REST_21632747_ChIP-Seq_MESCs_Mouse2.14983091
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14179769
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11010252
20DROSHA_22980978_ChIP-Seq_HELA_Human2.10507465
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09773865
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.07672571
23GBX2_23144817_ChIP-Seq_PC3_Human2.04579352
24* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02141288
25VDR_21846776_ChIP-Seq_THP-1_Human2.01607780
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.98843120
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95885638
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.92185726
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.85721259
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.83019052
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.81995628
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80922824
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.78346266
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78249901
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73087160
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71692883
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70908082
38* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.69603504
39CLOCK_20551151_ChIP-Seq_293T_Human1.66710421
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65349448
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63379985
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61855888
43KDM2B_26808549_Chip-Seq_DND41_Human1.60223106
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60212019
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60123063
46* TET1_21451524_ChIP-Seq_MESCs_Mouse1.58740433
47AR_21572438_ChIP-Seq_LNCaP_Human1.57178874
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57076324
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55520582
50ATF3_27146783_Chip-Seq_COLON_Human1.52277473
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51335782
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49195159
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48344044
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.47440154
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.46685695
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46476634
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46252298
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45759104
59P68_20966046_ChIP-Seq_HELA_Human1.42253693
60TCF7_22412390_ChIP-Seq_EML_Mouse1.41964056
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41880032
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.41775693
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41674354
64KDM2B_26808549_Chip-Seq_K562_Human1.40442246
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.40046701
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39837010
67ZNF263_19887448_ChIP-Seq_K562_Human1.36701878
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35511962
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35241518
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34649774
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33150539
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.32281787
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29930718
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29930718
75CTCF_27219007_Chip-Seq_Bcells_Human1.26267536
76* TP63_22573176_ChIP-Seq_HFKS_Human1.24811152
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22182724
78ZNF274_21170338_ChIP-Seq_K562_Hela1.20678786
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20216317
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19781447
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.19664611
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18766655
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18492692
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.18323695
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18266608
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17885933
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17832153
88* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17790394
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14299571
90BCOR_27268052_Chip-Seq_Bcells_Human1.14269359
91MYC_22102868_ChIP-Seq_BL_Human1.14226217
92TP53_22127205_ChIP-Seq_IMR90_Human1.13536682
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13505014
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13422568
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13224918
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12933921
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.10709595
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.10709595
99SMAD4_21799915_ChIP-Seq_A2780_Human1.10526574
100VDR_24763502_ChIP-Seq_THP-1_Human1.10263323
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09326882
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.08694332
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.08392744
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07963009
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07710419
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.07415766
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.06645043
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04541555
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04138649
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03739007
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03699578
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.03512004
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02506524
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02081458
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01663667
116LXR_22292898_ChIP-Seq_THP-1_Human1.01538591
117BCL6_27268052_Chip-Seq_Bcells_Human0.99811905
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.99781374
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99724333
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98893906
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98039584
122* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97962718
123AHR_22903824_ChIP-Seq_MCF-7_Human0.97233879
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97227522
125SA1_27219007_Chip-Seq_Bcells_Human0.96880044
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.96473388
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96471446
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96374734
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95426851
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95218988
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94395589
132JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93861134
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.93858125
134RING1B_27294783_Chip-Seq_NPCs_Mouse0.93803386
135* AR_19668381_ChIP-Seq_PC3_Human0.93651528
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.92637190
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92456022
138SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92227666
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91689926
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91447698
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91351253
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.91067899
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90775824
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.90284739
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90141836
146* AR_25329375_ChIP-Seq_VCAP_Human0.90006088
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89557310
148CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89324102
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88882388
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88716087
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87600988
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86994255
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.86928353
154TAF15_26573619_Chip-Seq_HEK293_Human0.84778077
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83892992
156KLF4_19829295_ChIP-Seq_ESCs_Human0.82881993
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.82473073
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82135716
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82132462
160STAT3_23295773_ChIP-Seq_U87_Human0.81880851
161SMC4_20622854_ChIP-Seq_HELA_Human0.81823304
162BCAT_22108803_ChIP-Seq_LS180_Human0.81752734
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80853080
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.79868691
165KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79498745
166CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79410427
167RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78065865
168TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77901496
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77723814
170SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76763878
171CREB1_26743006_Chip-Seq_LNCaP_Human0.76710821
172RXR_22108803_ChIP-Seq_LS180_Human0.76380538
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76312086
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76027905
175SMAD3_21741376_ChIP-Seq_EPCs_Human0.75051418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.72197292
2MP0003705_abnormal_hypodermis_morpholog4.50668341
3MP0004270_analgesia3.57063357
4MP0003635_abnormal_synaptic_transmissio3.16174425
5MP0003880_abnormal_central_pattern3.10299422
6MP0005451_abnormal_body_composition2.88634547
7MP0001968_abnormal_touch/_nociception2.87327977
8MP0005501_abnormal_skin_physiology2.69852076
9MP0003453_abnormal_keratinocyte_physiol2.68266084
10MP0003566_abnormal_cell_adhesion2.63411103
11MP0002909_abnormal_adrenal_gland2.54493699
12MP0002734_abnormal_mechanical_nocicepti2.53918432
13MP0002735_abnormal_chemical_nociception2.47150902
14MP0009745_abnormal_behavioral_response2.46254626
15MP0003191_abnormal_cellular_cholesterol2.44909840
16MP0002063_abnormal_learning/memory/cond2.41598783
17MP0009046_muscle_twitch2.39447652
18MP0009840_abnormal_foam_cell2.39218412
19MP0004510_myositis2.38138706
20MP0002064_seizures2.37664140
21MP0004858_abnormal_nervous_system2.35748733
22MP0002733_abnormal_thermal_nociception2.30551889
23MP0003329_amyloid_beta_deposits2.28449466
24MP0002736_abnormal_nociception_after2.25469465
25MP0005409_darkened_coat_color2.15153533
26MP0008260_abnormal_autophagy2.13846126
27MP0002272_abnormal_nervous_system2.11998694
28MP0002060_abnormal_skin_morphology2.10475425
29MP0005058_abnormal_lysosome_morphology2.09379391
30MP0008438_abnormal_cutaneous_collagen2.06332842
31MP0009780_abnormal_chondrocyte_physiolo2.04322763
32MP0001970_abnormal_pain_threshold2.00324795
33MP0000751_myopathy1.99913096
34MP0005423_abnormal_somatic_nervous1.99697776
35MP0002572_abnormal_emotion/affect_behav1.99104003
36MP0002837_dystrophic_cardiac_calcinosis1.97702059
37MP0002822_catalepsy1.91160855
38MP0000013_abnormal_adipose_tissue1.90114489
39MP0001216_abnormal_epidermal_layer1.90035458
40MP0002877_abnormal_melanocyte_morpholog1.89824440
41MP0006276_abnormal_autonomic_nervous1.88178849
42MP0000467_abnormal_esophagus_morphology1.79916894
43MP0001849_ear_inflammation1.78152171
44MP0004947_skin_inflammation1.75090877
45MP0001440_abnormal_grooming_behavior1.74883187
46MP0001486_abnormal_startle_reflex1.68865549
47MP0002067_abnormal_sensory_capabilities1.66375493
48MP0000762_abnormal_tongue_morphology1.65044834
49MP0003941_abnormal_skin_development1.64802621
50MP0005023_abnormal_wound_healing1.63218506
51MP0009379_abnormal_foot_pigmentation1.62756652
52MP0002184_abnormal_innervation1.61688570
53MP0004272_abnormal_basement_membrane1.61387936
54MP0001501_abnormal_sleep_pattern1.60812935
55MP0010234_abnormal_vibrissa_follicle1.56734469
56MP0000678_abnormal_parathyroid_gland1.56223460
57MP0002098_abnormal_vibrissa_morphology1.55503880
58MP0008569_lethality_at_weaning1.54560781
59MP0004145_abnormal_muscle_electrophysio1.53057090
60MP0001958_emphysema1.51750717
61MP0010771_integument_phenotype1.50352014
62MP0000750_abnormal_muscle_regeneration1.43620364
63MP0004811_abnormal_neuron_physiology1.43302565
64MP0000955_abnormal_spinal_cord1.42494560
65MP0004185_abnormal_adipocyte_glucose1.39914738
66MP0005257_abnormal_intraocular_pressure1.39877427
67MP0003879_abnormal_hair_cell1.39353999
68MP0010386_abnormal_urinary_bladder1.38957311
69MP0002796_impaired_skin_barrier1.34324909
70MP0005330_cardiomyopathy1.32587217
71MP0001502_abnormal_circadian_rhythm1.31999910
72MP0004885_abnormal_endolymph1.31931891
73MP0004043_abnormal_pH_regulation1.30440802
74MP0002557_abnormal_social/conspecific_i1.28739179
75MP0004924_abnormal_behavior1.26304779
76MP0005386_behavior/neurological_phenoty1.26304779
77MP0000858_altered_metastatic_potential1.25192931
78MP0005165_increased_susceptibility_to1.23871989
79MP0003633_abnormal_nervous_system1.23208840
80MP0003091_abnormal_cell_migration1.22648209
81MP0004087_abnormal_muscle_fiber1.21592233
82MP0005375_adipose_tissue_phenotype1.20541514
83MP0000747_muscle_weakness1.19523490
84MP0004142_abnormal_muscle_tone1.18265252
85MP0002882_abnormal_neuron_morphology1.17628124
86MP0002066_abnormal_motor_capabilities/c1.16651823
87MP0008961_abnormal_basal_metabolism1.16531860
88MP0005166_decreased_susceptibility_to1.16389402
89MP0005666_abnormal_adipose_tissue1.15070363
90MP0000377_abnormal_hair_follicle1.13829926
91MP0000778_abnormal_nervous_system1.13006662
92MP0001984_abnormal_olfaction1.12166772
93MP0009931_abnormal_skin_appearance1.11607478
94MP0003283_abnormal_digestive_organ1.11046280
95MP0000749_muscle_degeneration1.08634559
96MP0003279_aneurysm1.07418150
97MP0002229_neurodegeneration1.06242815
98MP0005551_abnormal_eye_electrophysiolog1.06129765
99MP0002234_abnormal_pharynx_morphology1.05646009
100MP0000733_abnormal_muscle_development1.05293162
101MP0004036_abnormal_muscle_relaxation1.03908567
102MP0004264_abnormal_extraembryonic_tissu1.03761306
103MP0005646_abnormal_pituitary_gland1.02417670
104MP0010352_gastrointestinal_tract_polyps1.01950045
105MP0004381_abnormal_hair_follicle1.01620956
106MP0000604_amyloidosis1.00717315
107MP0006138_congestive_heart_failure0.97527590
108MP0002090_abnormal_vision0.97356112
109MP0003631_nervous_system_phenotype0.97355027
110MP0002332_abnormal_exercise_endurance0.94519149
111MP0003300_gastrointestinal_ulcer0.94036649
112MP0005076_abnormal_cell_differentiation0.94029774
113MP0002896_abnormal_bone_mineralization0.93878046
114MP0004085_abnormal_heartbeat0.93394338
115MP0005535_abnormal_body_temperature0.93354198
116MP0000579_abnormal_nail_morphology0.93246204
117MP0004130_abnormal_muscle_cell0.90616081
118MP0003828_pulmonary_edema0.90553135
119MP0001243_abnormal_dermal_layer0.90323684
120MP0003634_abnormal_glial_cell0.89793494
121MP0001299_abnormal_eye_distance/0.89230496
122MP0002069_abnormal_eating/drinking_beha0.88146737
123MP0010678_abnormal_skin_adnexa0.87507211
124MP0005360_urolithiasis0.87176368
125MP0006072_abnormal_retinal_apoptosis0.86887865
126MP0000566_synostosis0.86236397
127MP0004215_abnormal_myocardial_fiber0.85918765
128MP0000003_abnormal_adipose_tissue0.85279590
129MP0005645_abnormal_hypothalamus_physiol0.84845991
130MP0009053_abnormal_anal_canal0.83749036
131MP0001905_abnormal_dopamine_level0.83643639
132MP0000343_altered_response_to0.83261523
133MP0003646_muscle_fatigue0.82862761
134MP0004233_abnormal_muscle_weight0.82860475
135MP0003436_decreased_susceptibility_to0.82750679
136MP0005275_abnormal_skin_tensile0.82631417
137MP0004782_abnormal_surfactant_physiolog0.81738146
138MP0008874_decreased_physiological_sensi0.78241983
139MP0002972_abnormal_cardiac_muscle0.78176155
140MP0000462_abnormal_digestive_system0.78050864
141MP0003303_peritoneal_inflammation0.77964046
142MP0000537_abnormal_urethra_morphology0.77847245
143MP0001765_abnormal_ion_homeostasis0.77106060
144MP0001986_abnormal_taste_sensitivity0.76821752
145MP0005620_abnormal_muscle_contractility0.76463954
146MP0002089_abnormal_postnatal_growth/wei0.75463889
147MP0010368_abnormal_lymphatic_system0.75462572
148MP0000920_abnormal_myelination0.74630282
149MP0003195_calcinosis0.74445257
150MP0005623_abnormal_meninges_morphology0.74223522
151MP0001664_abnormal_digestion0.74090117
152MP0002269_muscular_atrophy0.72903042
153MP0003137_abnormal_impulse_conducting0.72536219
154MP0005083_abnormal_biliary_tract0.71152021
155MP0004484_altered_response_of0.71055690
156MP0008872_abnormal_physiological_respon0.70927742
157MP0010630_abnormal_cardiac_muscle0.69501949
158MP0005187_abnormal_penis_morphology0.68429544
159MP0003632_abnormal_nervous_system0.66803169
160MP0002078_abnormal_glucose_homeostasis0.66569763
161MP0003806_abnormal_nucleotide_metabolis0.66281609
162MP0002998_abnormal_bone_remodeling0.65522505
163MP0001542_abnormal_bone_strength0.65451605
164MP0005167_abnormal_blood-brain_barrier0.64763422
165MP0003075_altered_response_to0.64066576
166MP0000230_abnormal_systemic_arterial0.64006211
167MP0004084_abnormal_cardiac_muscle0.64004836
168MP0000759_abnormal_skeletal_muscle0.63767180
169MP0001533_abnormal_skeleton_physiology0.63670735
170MP0002152_abnormal_brain_morphology0.63645417
171MP0003448_altered_tumor_morphology0.63365767
172MP0001851_eye_inflammation0.62999816
173MP0000367_abnormal_coat/_hair0.61930960
174MP0003950_abnormal_plasma_membrane0.60509801

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.27421865
2Visual hallucinations (HP:0002367)4.20264271
3Focal motor seizures (HP:0011153)4.18051809
4Distal lower limb muscle weakness (HP:0009053)4.00273788
5Abnormality of nail color (HP:0100643)3.90762287
6Atrophic scars (HP:0001075)3.73430700
7Focal seizures (HP:0007359)3.64968950
8Action tremor (HP:0002345)3.58781876
9Onycholysis (HP:0001806)3.48649679
10Atonic seizures (HP:0010819)3.42461687
11Supranuclear gaze palsy (HP:0000605)3.38106850
12Plantar hyperkeratosis (HP:0007556)3.34232707
13Distal lower limb amyotrophy (HP:0008944)3.31836037
14Fragile nails (HP:0001808)3.30068904
15Milia (HP:0001056)3.25340621
16Ankle clonus (HP:0011448)3.15734708
17Ventricular fibrillation (HP:0001663)3.14083428
18Progressive cerebellar ataxia (HP:0002073)3.12464592
19Pheochromocytoma (HP:0002666)3.07178531
20Increased connective tissue (HP:0009025)3.02724622
21Absence seizures (HP:0002121)3.02282562
22Alopecia of scalp (HP:0002293)3.01687337
23Epileptic encephalopathy (HP:0200134)3.01579593
24Thick nail (HP:0001805)2.99757617
25Nail dystrophy (HP:0008404)2.92536938
26Fragile skin (HP:0001030)2.92098967
27Palmoplantar hyperkeratosis (HP:0000972)2.86338601
28Axonal loss (HP:0003447)2.85972537
29Generalized tonic-clonic seizures (HP:0002069)2.82758797
30Type 1 muscle fiber predominance (HP:0003803)2.82619119
31Premature rupture of membranes (HP:0001788)2.81501788
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.80184519
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.76920859
34Mildly elevated creatine phosphokinase (HP:0008180)2.74345723
35Febrile seizures (HP:0002373)2.73856288
36Depression (HP:0000716)2.71021673
37Hypercortisolism (HP:0001578)2.69541710
38Ventricular tachycardia (HP:0004756)2.65437979
39Dialeptic seizures (HP:0011146)2.63934257
40Protrusio acetabuli (HP:0003179)2.63711841
41Anxiety (HP:0000739)2.61054471
42Neuroendocrine neoplasm (HP:0100634)2.59341767
43Myotonia (HP:0002486)2.56140233
44Vertebral compression fractures (HP:0002953)2.55620274
45Neurofibrillary tangles (HP:0002185)2.54889694
46Palmar hyperkeratosis (HP:0010765)2.54479341
47Lower limb amyotrophy (HP:0007210)2.50359937
48Ulnar claw (HP:0001178)2.49574275
49Exercise-induced myalgia (HP:0003738)2.47972444
50Pili torti (HP:0003777)2.47305902
51Cerebral inclusion bodies (HP:0100314)2.45929877
52Hyporeflexia of lower limbs (HP:0002600)2.45784281
53Abnormal blistering of the skin (HP:0008066)2.44336596
54Dysdiadochokinesis (HP:0002075)2.39375211
55Myopathic facies (HP:0002058)2.37190874
56Ridged nail (HP:0001807)2.36027138
57Termporal pattern (HP:0011008)2.35827888
58Insidious onset (HP:0003587)2.35827888
59Sudden death (HP:0001699)2.35536242
60Hypotrichosis (HP:0001006)2.35292579
61Increased IgE level (HP:0003212)2.34860660
62Agitation (HP:0000713)2.33656815
63Abnormality of skeletal muscle fiber size (HP:0012084)2.33249638
64Torticollis (HP:0000473)2.32229188
65Abnormal eating behavior (HP:0100738)2.30862512
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29680236
67Limb dystonia (HP:0002451)2.28496563
68Abnormality of the lower motor neuron (HP:0002366)2.28179049
69Dysmetria (HP:0001310)2.27817149
70Muscle fiber inclusion bodies (HP:0100299)2.26844462
71Amblyopia (HP:0000646)2.25449205
72Rapidly progressive (HP:0003678)2.24870541
73Bundle branch block (HP:0011710)2.24389832
74Erythema (HP:0010783)2.24118307
75Nemaline bodies (HP:0003798)2.23196524
76Spinal rigidity (HP:0003306)2.20826661
77Mutism (HP:0002300)2.19524060
78Intention tremor (HP:0002080)2.17185862
79Cerebral aneurysm (HP:0004944)2.13336500
80Truncal ataxia (HP:0002078)2.11440888
81Achilles tendon contracture (HP:0001771)2.11305476
82Congenital ichthyosiform erythroderma (HP:0007431)2.11039424
83Acanthosis nigricans (HP:0000956)2.10770602
84Natal tooth (HP:0000695)2.10667870
85Postural instability (HP:0002172)2.10579746
86Hyperacusis (HP:0010780)2.08392134
87Asymmetric septal hypertrophy (HP:0001670)2.08203459
88Abnormal hair laboratory examination (HP:0003328)2.07736092
89Focal dystonia (HP:0004373)2.07712469
90Abnormal social behavior (HP:0012433)2.07334158
91Impaired social interactions (HP:0000735)2.07334158
92Malnutrition (HP:0004395)2.06928601
93Poor eye contact (HP:0000817)2.06098250
94Central scotoma (HP:0000603)2.03940289
95Prolonged QT interval (HP:0001657)2.03856798
96Hypoventilation (HP:0002791)2.03474724
97Scanning speech (HP:0002168)2.02875454
98Abnormality of the Achilles tendon (HP:0005109)2.01611963
99Postural tremor (HP:0002174)2.01608968
100Abnormality of glycolipid metabolism (HP:0010969)2.01281297
101Abnormality of liposaccharide metabolism (HP:0010968)2.01281297
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.01281297
103Craniofacial dystonia (HP:0012179)2.01253559
104Bulbar palsy (HP:0001283)2.00807489
105Syncope (HP:0001279)2.00497984
106Round ear (HP:0100830)1.99911844
107Thin bony cortex (HP:0002753)1.97970383
108Muscle fiber splitting (HP:0003555)1.97624166
109EMG: myopathic abnormalities (HP:0003458)1.96792613
110Impaired vibration sensation in the lower limbs (HP:0002166)1.94882580
111EEG with generalized epileptiform discharges (HP:0011198)1.93737015
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.93194130
113Epileptiform EEG discharges (HP:0011182)1.93108270
114Urinary urgency (HP:0000012)1.89467995
115Distal upper limb amyotrophy (HP:0007149)1.89066972
116Upper limb amyotrophy (HP:0009129)1.89066972
117Hammertoe (HP:0001765)1.88601453
118Megalencephaly (HP:0001355)1.88372960
119Broad face (HP:0000283)1.87883906
120Abnormal EKG (HP:0003115)1.87422898
121Neoplasm of the peripheral nervous system (HP:0100007)1.87048113
122Increased variability in muscle fiber diameter (HP:0003557)1.86417298
123Adrenal overactivity (HP:0002717)1.85677407
124Short nail (HP:0001799)1.85632391
125Neck muscle weakness (HP:0000467)1.85153101
126Rigidity (HP:0002063)1.84761390
127Failure to thrive in infancy (HP:0001531)1.84165597
128Spastic gait (HP:0002064)1.84051280
129Foot dorsiflexor weakness (HP:0009027)1.84033568
130Ketoacidosis (HP:0001993)1.83912676
131Advanced eruption of teeth (HP:0006288)1.83682404
132Right ventricular cardiomyopathy (HP:0011663)1.83150083
133Trismus (HP:0000211)1.83102072
134Palmoplantar keratoderma (HP:0000982)1.82819701
135Osteolytic defects of the hand bones (HP:0009699)1.82467413
136Osteolytic defects of the phalanges of the hand (HP:0009771)1.82467413
137Bradycardia (HP:0001662)1.81905322
138Hypsarrhythmia (HP:0002521)1.81802839
139Bradykinesia (HP:0002067)1.81793558
140Ragged-red muscle fibers (HP:0003200)1.81725661
141Urinary bladder sphincter dysfunction (HP:0002839)1.81305205
142Genetic anticipation (HP:0003743)1.80701820
143Gout (HP:0001997)1.79545745
144Delusions (HP:0000746)1.79510188
145Elbow flexion contracture (HP:0002987)1.79314001
146Generalized amyotrophy (HP:0003700)1.78975413
147Reduced subcutaneous adipose tissue (HP:0003758)1.78042629
148Abnormal atrioventricular conduction (HP:0005150)1.77871394
149Hyperparathyroidism (HP:0000843)1.77823342
150Status epilepticus (HP:0002133)1.77804224
151Cholecystitis (HP:0001082)1.77771231
152Abnormal gallbladder physiology (HP:0012438)1.77771231
153Muscle stiffness (HP:0003552)1.77318380
154Increased circulating renin level (HP:0000848)1.77201946
155Clonus (HP:0002169)1.76976287
156Abnormality of the foot musculature (HP:0001436)1.74833134
157Papilledema (HP:0001085)1.74371770
158Lower limb muscle weakness (HP:0007340)1.74223743
159Difficulty running (HP:0009046)1.73901834
160Difficulty climbing stairs (HP:0003551)1.72914392
161Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72096349
162Hand muscle atrophy (HP:0009130)1.72050793
163Eczematoid dermatitis (HP:0000976)1.71605614
164Obstructive sleep apnea (HP:0002870)1.71381621
165Neuronal loss in central nervous system (HP:0002529)1.71018082
166Abnormality of pain sensation (HP:0010832)1.70338206
167Impaired pain sensation (HP:0007328)1.70338206
168Rhabdomyolysis (HP:0003201)1.69979482
169Onion bulb formation (HP:0003383)1.68060641
170Neonatal death (HP:0003811)1.67873977
171Vascular tortuosity (HP:0004948)1.66999811
172Abnormality of the distal phalanges of the toes (HP:0010182)1.66056808
173Growth hormone excess (HP:0000845)1.66030441
174Abnormality of the salivary glands (HP:0010286)1.65307703
175Back pain (HP:0003418)1.65182410
176Stridor (HP:0010307)1.65083482
177Wormian bones (HP:0002645)1.63900258
178Scapular winging (HP:0003691)1.61871677
179Spinal cord compression (HP:0002176)1.61546198
180Amyloidosis (HP:0011034)1.61268398
181Ulnar bowing (HP:0003031)1.60528051
182Polygenic inheritance (HP:0010982)1.60442362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.54057538
2EPHA23.40316270
3NTRK33.13788730
4TESK12.81334988
5NME22.65640132
6TTN2.60010531
7MINK12.55520555
8IRAK32.54062911
9KSR22.50655622
10PRPF4B2.49753406
11MAP3K42.39955448
12MARK12.33212801
13NTRK12.30720724
14EPHA42.29861291
15PAK62.26748497
16MAP3K22.05307956
17MAP2K42.02026822
18PRKD32.00210622
19SMG11.99495192
20SIK11.91888609
21DAPK21.91001425
22PHKG11.87572120
23PHKG21.87572120
24GRK51.84837428
25ARAF1.70888046
26MAP2K71.69374229
27EPHB21.69238184
28MAP3K121.66366347
29FER1.62879337
30LMTK21.60686574
31MAP3K31.59756783
32PIM21.56374063
33LATS21.54201970
34TESK21.53601764
35PINK11.51480857
36CAMKK11.50740955
37TAOK21.44270611
38ICK1.40781781
39PAK41.38004198
40CAMKK21.34887437
41MAPKAPK31.32334764
42NTRK21.31747457
43RET1.30730385
44MYLK1.30067182
45ABL21.28079820
46CDK51.26266666
47STK381.25490915
48PAK31.24549793
49PDGFRA1.24192398
50PKN21.23586041
51MET1.20794340
52UHMK11.20532854
53LIMK11.19502303
54MOS1.17915959
55MAP3K11.17872677
56WNK41.17171808
57TRIB31.16290167
58RIPK11.16119079
59MAP2K31.15529657
60TAOK11.14711324
61EPHB11.14006631
62ILK1.03849491
63TBK11.03579217
64TGFBR21.00668124
65EEF2K0.98638550
66KSR10.98554925
67NME10.96076728
68PTK60.91359980
69MAP2K10.91163361
70SGK2230.90735538
71SGK4940.90735538
72CAMK2A0.90117585
73PRKCH0.87214051
74PRKD20.86674687
75RPS6KA20.85462182
76WNK10.84334337
77PRKCG0.80237883
78CAMK2D0.79986952
79CAMK2G0.79662366
80CDK140.79465875
81CDK190.79062427
82TYRO30.78384393
83NEK10.76799327
84OXSR10.76430550
85MAPK120.74988360
86MARK20.73965634
87CAMK2B0.73787899
88PLK20.73639350
89SCYL20.73232762
90PTK20.72390869
91MST1R0.72249224
92INSRR0.71012111
93MUSK0.70837500
94MAPK130.70460255
95DAPK10.68585933
96WNK30.67749198
97STK110.66776406
98PDPK10.66012020
99CDK150.65558172
100CDK180.64697417
101STK390.62698774
102IRAK20.61913364
103CSNK1G20.61362471
104PRKCE0.60496229
105CASK0.59598625
106CAMK10.59517069
107PTK2B0.58429838
108RIPK40.58249695
109MAP2K20.57820386
110CDC42BPA0.57312442
111DMPK0.56004974
112CDK11A0.55272507
113LRRK20.55073350
114DAPK30.54649535
115KDR0.53738732
116MTOR0.53643532
117MAP3K60.53583186
118PRKD10.52503101
119MAP3K110.51874631
120BRAF0.51691613
121MAPKAPK50.51123083
122BMX0.50293346
123HIPK20.49579557
124ALK0.48814265
125RPS6KL10.48571316
126RPS6KC10.48571316
127FES0.48251721
128PRKCZ0.47063233
129PDK10.46936390
130OBSCN0.46914549
131MAP3K130.46803524
132RAF10.46290260
133MAP3K70.45769635
134PAK20.45714979
135ROCK20.45316536
136ERN10.44990841
137SIK20.44848281
138MAP2K60.44473875
139ROCK10.44037559
140DDR20.43968956
141PRKG20.43715039
142MAP3K80.43101391
143MAPK150.42933712
144EPHA30.42551853
145RPS6KB20.42306015
146MAPK40.40142303
147MAPK110.38304095
148PRKCI0.37214547
149AKT20.37040407
150ZAP700.37030535
151PAK10.35120195
152MAPKAPK20.31929219

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047213.00166284
2* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.34010191
3Nicotine addiction_Homo sapiens_hsa050332.28184519
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24259190
5GABAergic synapse_Homo sapiens_hsa047272.23211331
6Circadian entrainment_Homo sapiens_hsa047132.08902197
7Insulin secretion_Homo sapiens_hsa049112.05687210
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99356396
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97661011
10Olfactory transduction_Homo sapiens_hsa047401.88097653
11Long-term potentiation_Homo sapiens_hsa047201.86131179
12Other glycan degradation_Homo sapiens_hsa005111.82151884
13Fructose and mannose metabolism_Homo sapiens_hsa000511.81516770
14Glutamatergic synapse_Homo sapiens_hsa047241.81179813
15Dopaminergic synapse_Homo sapiens_hsa047281.75848895
16Morphine addiction_Homo sapiens_hsa050321.75147539
17Amphetamine addiction_Homo sapiens_hsa050311.72145383
18Salivary secretion_Homo sapiens_hsa049701.70946107
19Gastric acid secretion_Homo sapiens_hsa049711.62900265
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61921888
21Galactose metabolism_Homo sapiens_hsa000521.60588179
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57412225
23Cholinergic synapse_Homo sapiens_hsa047251.57203113
24* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55782530
25Taste transduction_Homo sapiens_hsa047421.54655974
26Pentose phosphate pathway_Homo sapiens_hsa000301.51067930
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49792342
28Collecting duct acid secretion_Homo sapiens_hsa049661.48570920
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47917268
30Amoebiasis_Homo sapiens_hsa051461.43306444
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41797811
32Focal adhesion_Homo sapiens_hsa045101.41715453
33Sulfur relay system_Homo sapiens_hsa041221.40931271
34Serotonergic synapse_Homo sapiens_hsa047261.39823694
35Cocaine addiction_Homo sapiens_hsa050301.39617907
36Renin secretion_Homo sapiens_hsa049241.38815414
37Long-term depression_Homo sapiens_hsa047301.35539585
38GnRH signaling pathway_Homo sapiens_hsa049121.34732250
39Cardiac muscle contraction_Homo sapiens_hsa042601.34598380
40Nitrogen metabolism_Homo sapiens_hsa009101.31351193
41Oxytocin signaling pathway_Homo sapiens_hsa049211.31002353
42Salmonella infection_Homo sapiens_hsa051321.26667005
43Vibrio cholerae infection_Homo sapiens_hsa051101.26593254
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.26466710
45ECM-receptor interaction_Homo sapiens_hsa045121.23730053
46Gap junction_Homo sapiens_hsa045401.21669741
47Shigellosis_Homo sapiens_hsa051311.13577613
48Chronic myeloid leukemia_Homo sapiens_hsa052201.11742857
49Acute myeloid leukemia_Homo sapiens_hsa052211.11555230
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09391340
51Calcium signaling pathway_Homo sapiens_hsa040201.07880806
52Type II diabetes mellitus_Homo sapiens_hsa049301.07780877
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05686212
54Phenylalanine metabolism_Homo sapiens_hsa003601.02953437
55Pancreatic secretion_Homo sapiens_hsa049721.01860388
56* Lysosome_Homo sapiens_hsa041421.01382078
57Estrogen signaling pathway_Homo sapiens_hsa049151.01285851
58Bile secretion_Homo sapiens_hsa049761.00102305
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99618248
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99518627
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.98957301
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.98907807
63Proteoglycans in cancer_Homo sapiens_hsa052050.95827098
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.95594886
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95573323
66Dilated cardiomyopathy_Homo sapiens_hsa054140.94078235
67cAMP signaling pathway_Homo sapiens_hsa040240.92574213
68Pancreatic cancer_Homo sapiens_hsa052120.89628358
69Glioma_Homo sapiens_hsa052140.88221994
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85184094
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84852968
72Biosynthesis of amino acids_Homo sapiens_hsa012300.84166811
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82872486
74ErbB signaling pathway_Homo sapiens_hsa040120.82731673
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82707986
76Dorso-ventral axis formation_Homo sapiens_hsa043200.81712042
77Arginine and proline metabolism_Homo sapiens_hsa003300.80262373
78Thyroid hormone synthesis_Homo sapiens_hsa049180.80227533
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79811662
80Melanogenesis_Homo sapiens_hsa049160.79366611
81Axon guidance_Homo sapiens_hsa043600.79013225
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78794225
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.77977222
84Butanoate metabolism_Homo sapiens_hsa006500.77949922
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77766435
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77128333
87Small cell lung cancer_Homo sapiens_hsa052220.76984324
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76738837
89Oxidative phosphorylation_Homo sapiens_hsa001900.76705927
90Toxoplasmosis_Homo sapiens_hsa051450.76541947
91Alzheimers disease_Homo sapiens_hsa050100.76020524
92Hepatitis C_Homo sapiens_hsa051600.75442098
93Carbon metabolism_Homo sapiens_hsa012000.75040625
94Notch signaling pathway_Homo sapiens_hsa043300.74623308
95Non-small cell lung cancer_Homo sapiens_hsa052230.74066266
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.72765123
97AMPK signaling pathway_Homo sapiens_hsa041520.72100080
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70575932
99Sphingolipid metabolism_Homo sapiens_hsa006000.70323914
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69236078
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68974577
102Pertussis_Homo sapiens_hsa051330.68663829
103Thyroid cancer_Homo sapiens_hsa052160.67537809
104Glucagon signaling pathway_Homo sapiens_hsa049220.66993643
105Parkinsons disease_Homo sapiens_hsa050120.66911432
106VEGF signaling pathway_Homo sapiens_hsa043700.66611813
107Protein digestion and absorption_Homo sapiens_hsa049740.66468018
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65754095
109PPAR signaling pathway_Homo sapiens_hsa033200.64997308
110Circadian rhythm_Homo sapiens_hsa047100.64222702
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.64030700
112Apoptosis_Homo sapiens_hsa042100.63030784
113Arginine biosynthesis_Homo sapiens_hsa002200.62754128
114Insulin signaling pathway_Homo sapiens_hsa049100.62534667
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62136303
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61543004
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61509097
118Osteoclast differentiation_Homo sapiens_hsa043800.58843571
119Vitamin B6 metabolism_Homo sapiens_hsa007500.58694253
120Prion diseases_Homo sapiens_hsa050200.57618180
121Adherens junction_Homo sapiens_hsa045200.57488725
122Insulin resistance_Homo sapiens_hsa049310.56817009
123TNF signaling pathway_Homo sapiens_hsa046680.56736609
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55557932
125Choline metabolism in cancer_Homo sapiens_hsa052310.53231770
126Tuberculosis_Homo sapiens_hsa051520.53042602
127Phototransduction_Homo sapiens_hsa047440.52576703
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51712585
129Renal cell carcinoma_Homo sapiens_hsa052110.50904228
130* Endocytosis_Homo sapiens_hsa041440.49370387
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49363918
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48124878
133Ras signaling pathway_Homo sapiens_hsa040140.48087962
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.47799284
135mTOR signaling pathway_Homo sapiens_hsa041500.45578405
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.45446409
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45365270
138MAPK signaling pathway_Homo sapiens_hsa040100.44809080
139Ovarian steroidogenesis_Homo sapiens_hsa049130.42978732
140Inositol phosphate metabolism_Homo sapiens_hsa005620.41005674
141Mineral absorption_Homo sapiens_hsa049780.40836462
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.39409932
143Endometrial cancer_Homo sapiens_hsa052130.39307793
144Rap1 signaling pathway_Homo sapiens_hsa040150.37920245
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.37363909
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36557410
147Sulfur metabolism_Homo sapiens_hsa009200.36333347
148Bladder cancer_Homo sapiens_hsa052190.36144153
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35776068
150Tight junction_Homo sapiens_hsa045300.35551869
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35298253
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34750444

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