CLUH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)5.75851247
2lysine metabolic process (GO:0006553)5.75851247
3L-phenylalanine catabolic process (GO:0006559)5.61956911
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.61956911
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56915717
6L-phenylalanine metabolic process (GO:0006558)5.56915717
7alpha-linolenic acid metabolic process (GO:0036109)5.30548494
8glyoxylate metabolic process (GO:0046487)5.08081036
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.00396519
102-oxoglutarate metabolic process (GO:0006103)4.95587680
11aromatic amino acid family catabolic process (GO:0009074)4.94472428
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94139643
13kynurenine metabolic process (GO:0070189)4.90163020
14fatty acid transmembrane transport (GO:1902001)4.80757201
15carnitine shuttle (GO:0006853)4.74837700
16proline biosynthetic process (GO:0006561)4.72705333
17cysteine metabolic process (GO:0006534)4.69011144
18amino-acid betaine metabolic process (GO:0006577)4.64390066
19fatty acid beta-oxidation (GO:0006635)4.64004349
20sulfur amino acid catabolic process (GO:0000098)4.62337758
21valine metabolic process (GO:0006573)4.56829401
22urea metabolic process (GO:0019627)4.56590973
23urea cycle (GO:0000050)4.56590973
24acetyl-CoA metabolic process (GO:0006084)4.54795061
25regulation of triglyceride catabolic process (GO:0010896)4.48750893
26serine family amino acid catabolic process (GO:0009071)4.45012280
27aspartate family amino acid catabolic process (GO:0009068)4.42799924
28tryptophan catabolic process (GO:0006569)4.41636160
29indole-containing compound catabolic process (GO:0042436)4.41636160
30indolalkylamine catabolic process (GO:0046218)4.41636160
31bile acid biosynthetic process (GO:0006699)4.39699222
32positive regulation of fatty acid beta-oxidation (GO:0032000)4.39185937
33homocysteine metabolic process (GO:0050667)4.32752351
34Golgi transport vesicle coating (GO:0048200)4.29688797
35COPI coating of Golgi vesicle (GO:0048205)4.29688797
36fatty acid oxidation (GO:0019395)4.28538198
37complement activation, alternative pathway (GO:0006957)4.24278778
38lipid oxidation (GO:0034440)4.19245422
39nitrogen cycle metabolic process (GO:0071941)4.16931996
40tryptophan metabolic process (GO:0006568)4.14842795
41fatty acid catabolic process (GO:0009062)4.13398030
42dicarboxylic acid biosynthetic process (GO:0043650)4.12626262
43negative regulation of fibrinolysis (GO:0051918)4.11539003
44desmosome organization (GO:0002934)4.10440513
45carnitine metabolic process (GO:0009437)4.06290836
46regulation of sequestering of triglyceride (GO:0010889)4.05631008
47cellular ketone body metabolic process (GO:0046950)4.05111618
48regulation of fatty acid beta-oxidation (GO:0031998)4.04469228
49alpha-amino acid catabolic process (GO:1901606)4.04454630
50short-chain fatty acid metabolic process (GO:0046459)4.02602704
51regulation of protein activation cascade (GO:2000257)4.01991551
52tricarboxylic acid metabolic process (GO:0072350)4.01913288
53triglyceride homeostasis (GO:0070328)4.01063561
54acylglycerol homeostasis (GO:0055090)4.01063561
55tricarboxylic acid cycle (GO:0006099)4.00024552
56protein carboxylation (GO:0018214)3.99494241
57peptidyl-glutamic acid carboxylation (GO:0017187)3.99494241
58glycine metabolic process (GO:0006544)3.98323183
59cell-substrate adherens junction assembly (GO:0007045)3.95459846
60focal adhesion assembly (GO:0048041)3.95459846
61positive regulation of fatty acid oxidation (GO:0046321)3.93774117
62plasma lipoprotein particle clearance (GO:0034381)3.93110676
63biotin metabolic process (GO:0006768)3.92946743
64regulation of fatty acid oxidation (GO:0046320)3.92053409
65oxaloacetate metabolic process (GO:0006107)3.90931962
66monocarboxylic acid catabolic process (GO:0072329)3.90601554
67high-density lipoprotein particle remodeling (GO:0034375)3.88065469
68adherens junction assembly (GO:0034333)3.86845926
69phospholipid homeostasis (GO:0055091)3.85809721
70negative regulation of cell size (GO:0045792)3.84726641
71ethanol oxidation (GO:0006069)3.84056986
72regulation of translational fidelity (GO:0006450)3.83546468
73regulation of cholesterol homeostasis (GO:2000188)3.82539562
74cellular amino acid catabolic process (GO:0009063)3.82404936
75apoptotic process involved in morphogenesis (GO:0060561)3.79924692
76carnitine transmembrane transport (GO:1902603)3.79498414
77regulation of complement activation (GO:0030449)3.78145038
78bile acid metabolic process (GO:0008206)3.77477612
79positive regulation of lipid catabolic process (GO:0050996)3.77218603
80carnitine transport (GO:0015879)3.76298354
81amino-acid betaine transport (GO:0015838)3.76298354
82regulation of fibrinolysis (GO:0051917)3.75282461
83proline metabolic process (GO:0006560)3.74573216
84glutamate metabolic process (GO:0006536)3.73792962
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.71720440
86cellular modified amino acid catabolic process (GO:0042219)3.71577114
87serine family amino acid metabolic process (GO:0009069)3.71535626
88branched-chain amino acid catabolic process (GO:0009083)3.69935348
89branched-chain amino acid metabolic process (GO:0009081)3.66456028
90activation of Rac GTPase activity (GO:0032863)3.63195557
91organic acid catabolic process (GO:0016054)3.62476629
92carboxylic acid catabolic process (GO:0046395)3.62476629
93low-density lipoprotein particle clearance (GO:0034383)3.60584471
94negative regulation of sterol transport (GO:0032372)3.60080861
95negative regulation of cholesterol transport (GO:0032375)3.60080861
96regulation of glucose import in response to insulin stimulus (GO:2001273)3.57574825
97mitotic chromosome condensation (GO:0007076)3.56611751
98aromatic amino acid family metabolic process (GO:0009072)3.56565418
99fatty acid homeostasis (GO:0055089)3.54431002
100protein-lipid complex remodeling (GO:0034368)3.54061302
101macromolecular complex remodeling (GO:0034367)3.54061302
102plasma lipoprotein particle remodeling (GO:0034369)3.54061302
103DNA unwinding involved in DNA replication (GO:0006268)3.53416784
104NADH metabolic process (GO:0006734)3.51915385
105reverse cholesterol transport (GO:0043691)3.49826540
106cell-substrate junction assembly (GO:0007044)3.48751390
107ketone body metabolic process (GO:1902224)3.48122665
108serine family amino acid biosynthetic process (GO:0009070)3.44165629
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.44007586
110coenzyme catabolic process (GO:0009109)3.43640163
111regulation of mammary gland epithelial cell proliferation (GO:0033599)3.42026356
112tyrosine metabolic process (GO:0006570)3.40046362
113positive regulation of triglyceride metabolic process (GO:0090208)3.35908035
114regulation of cholesterol biosynthetic process (GO:0045540)3.32896137
115succinate metabolic process (GO:0006105)3.28179272
116protein localization to endosome (GO:0036010)3.27121977
117cytoskeletal anchoring at plasma membrane (GO:0007016)3.27105385
118regulation of cholesterol metabolic process (GO:0090181)3.26462896
119spliceosomal tri-snRNP complex assembly (GO:0000244)3.25714050
120regulation of cholesterol esterification (GO:0010872)3.25444837
121negative regulation of fatty acid metabolic process (GO:0045922)3.24328505
122quaternary ammonium group transport (GO:0015697)3.23879923
123epithelial cell-cell adhesion (GO:0090136)3.20870099
124maternal placenta development (GO:0001893)3.17305695
125hemidesmosome assembly (GO:0031581)3.17054414
126regulation of early endosome to late endosome transport (GO:2000641)3.13177910
127regulation of NFAT protein import into nucleus (GO:0051532)3.12206996
128pentose-phosphate shunt (GO:0006098)3.04341606
129nuclear pore complex assembly (GO:0051292)3.00965080
130regulation of translational termination (GO:0006449)3.00049071
131glucose 6-phosphate metabolic process (GO:0051156)2.99006821
132basement membrane organization (GO:0071711)2.97671987
133gluconeogenesis (GO:0006094)2.96764436
134glucose catabolic process (GO:0006007)2.93216943
135monosaccharide biosynthetic process (GO:0046364)2.89691404
136cellular protein complex localization (GO:0034629)2.86580592
137creatine metabolic process (GO:0006600)2.86557898
138negative regulation of fatty acid transport (GO:2000192)2.85524696
139hexose biosynthetic process (GO:0019319)2.84073676
140negative regulation of erythrocyte differentiation (GO:0045647)2.83831649
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79358374
142protein retention in ER lumen (GO:0006621)2.77701822
143maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77214692
144glutamine family amino acid biosynthetic process (GO:0009084)2.75771584
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75217466
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71843609
147peptidyl-arginine omega-N-methylation (GO:0035247)2.69960359
148protein complex localization (GO:0031503)2.68974814
149positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63886333
150folic acid metabolic process (GO:0046655)2.63698281
151NADPH regeneration (GO:0006740)2.59080286
152regulation of RNA export from nucleus (GO:0046831)2.58497270
153mRNA stabilization (GO:0048255)2.57540733
154RNA stabilization (GO:0043489)2.57540733
155regulation of nucleobase-containing compound transport (GO:0032239)2.55593382
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53637181
157intracellular estrogen receptor signaling pathway (GO:0030520)2.53060961
1583-UTR-mediated mRNA stabilization (GO:0070935)2.53057821
159semaphorin-plexin signaling pathway (GO:0071526)2.52783999
160protein localization to microtubule (GO:0035372)2.51591535
161negative regulation of viral release from host cell (GO:1902187)2.51547449
162mannose metabolic process (GO:0006013)2.51177422
163atrioventricular valve morphogenesis (GO:0003181)2.50723551
164embryonic process involved in female pregnancy (GO:0060136)2.48312411
165positive regulation of nuclease activity (GO:0032075)2.47181922
166cellular response to epidermal growth factor stimulus (GO:0071364)2.46762813
167branching involved in mammary gland duct morphogenesis (GO:0060444)2.46582873
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46019741
169mitochondrial fusion (GO:0008053)2.44847809
170glycolytic process (GO:0006096)2.43822271
171bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43636169
172activation of MAPKKK activity (GO:0000185)2.42399111
173regulation of water loss via skin (GO:0033561)2.41414136
174pinocytosis (GO:0006907)2.40854471
175positive regulation of Cdc42 GTPase activity (GO:0043089)2.40599169
1764-hydroxyproline metabolic process (GO:0019471)2.39403374
177negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.38173347
178mitotic G1 DNA damage checkpoint (GO:0031571)2.37409408
179positive regulation of keratinocyte differentiation (GO:0045618)2.33120316
180nuclear pore organization (GO:0006999)2.32331338
181peptidyl-lysine dimethylation (GO:0018027)2.31495391
182snRNA metabolic process (GO:0016073)2.31378423
183regulation of histone H3-K27 methylation (GO:0061085)2.30638642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.42920004
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.53678944
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.59281539
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.00442447
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.22026471
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.07686632
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01572680
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.73289403
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.69080233
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.30695264
11E2F7_22180533_ChIP-Seq_HELA_Human3.12082850
12CLOCK_20551151_ChIP-Seq_293T_Human2.62506458
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42690274
14ZNF263_19887448_ChIP-Seq_K562_Human2.35617019
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.02751692
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91951827
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89126678
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87101708
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86934567
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84995087
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.80430194
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78096124
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75436513
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75428925
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72297213
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.65579381
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.58644518
28GATA1_22025678_ChIP-Seq_K562_Human1.57625347
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56923658
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48838551
31CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46592445
32KDM2B_26808549_Chip-Seq_K562_Human1.45523039
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.45186854
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44877858
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44379955
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.43099251
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.43099251
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42351325
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40759014
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40121536
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39787125
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38294802
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38092158
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36567364
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.36246551
46CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36035535
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35641536
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34797851
49SMC4_20622854_ChIP-Seq_HELA_Human1.34668677
50LXR_22292898_ChIP-Seq_THP-1_Human1.33844294
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33575364
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33471299
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32680321
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.32380636
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30178391
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27822832
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.27090635
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24099799
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.23292662
60XRN2_22483619_ChIP-Seq_HELA_Human1.23259146
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22993659
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21455249
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18242149
64RACK7_27058665_Chip-Seq_MCF-7_Human1.14405026
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13136712
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11955541
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10173027
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.09999820
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09799904
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.09025158
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08881643
72ATF3_27146783_Chip-Seq_COLON_Human1.07791256
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07349576
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06488253
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06439919
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.06121416
77VDR_24763502_ChIP-Seq_THP-1_Human1.06065262
78MAF_26560356_Chip-Seq_TH1_Human1.05472035
79TP53_22127205_ChIP-Seq_IMR90_Human1.05191600
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.03954414
81MYC_22102868_ChIP-Seq_BL_Human1.03939177
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02403063
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01446509
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01077312
85NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98136469
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97780411
87MAF_26560356_Chip-Seq_TH2_Human0.97153119
88DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95671012
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95446730
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94593156
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.94089534
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91126470
93RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90989746
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90385356
95GATA6_25053715_ChIP-Seq_YYC3_Human0.87883663
96P68_20966046_ChIP-Seq_HELA_Human0.87609399
97KDM2B_26808549_Chip-Seq_DND41_Human0.86566901
98GATA1_19941826_ChIP-Seq_K562_Human0.86559782
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86256047
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85946360
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84785864
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83330716
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.82645485
104CREB1_26743006_Chip-Seq_LNCaP_Human0.81693412
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81651473
106TCF7_22412390_ChIP-Seq_EML_Mouse0.80922323
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.79398921
108HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79290743
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78991903
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78642767
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78116244
112GATA4_25053715_ChIP-Seq_YYC3_Human0.77546876
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77300044
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76867881
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76218560
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75855435
117BCOR_27268052_Chip-Seq_Bcells_Human0.75755858
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.75698253
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74337954
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.74035373
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.73910290
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72886146
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72306207
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71288377
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70985556
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.69244180
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.68901504
128AR_21909140_ChIP-Seq_LNCAP_Human0.68370198
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67301593
130GATA2_19941826_ChIP-Seq_K562_Human0.65706003
131CTCF_21964334_Chip-Seq_Bcells_Human0.65532108
132GATA4_21415370_ChIP-Seq_HL-1_Mouse0.65489039
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.64224151
134NCOR1_26117541_ChIP-Seq_K562_Human0.64138017
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63593974
136PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63249778
137BCL6_27268052_Chip-Seq_Bcells_Human0.63144310
138VDR_21846776_ChIP-Seq_THP-1_Human0.62726420
139TP63_22573176_ChIP-Seq_HFKS_Human0.62244499
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.62171643
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.62119743
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.61208735
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.61135028
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61041398
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.60764731
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60752720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.09409140
2MP0005360_urolithiasis5.89882244
3MP0005365_abnormal_bile_salt4.82310605
4MP0005085_abnormal_gallbladder_physiolo4.78488374
5MP0010234_abnormal_vibrissa_follicle3.83599379
6MP0003806_abnormal_nucleotide_metabolis3.49432115
7MP0008875_abnormal_xenobiotic_pharmacok3.45979358
8MP0002837_dystrophic_cardiac_calcinosis3.35425772
9MP0003252_abnormal_bile_duct3.19395452
10MP0010329_abnormal_lipoprotein_level3.15868527
11MP0005670_abnormal_white_adipose2.75684998
12MP0005076_abnormal_cell_differentiation2.72826843
13MP0009840_abnormal_foam_cell2.64597731
14MP0005332_abnormal_amino_acid2.49949509
15MP0003705_abnormal_hypodermis_morpholog2.49587054
16MP0004130_abnormal_muscle_cell2.49293370
17MP0002877_abnormal_melanocyte_morpholog2.42162609
18MP0003646_muscle_fatigue2.31729523
19MP0005083_abnormal_biliary_tract2.30554590
20MP0005666_abnormal_adipose_tissue2.15942450
21MP0003191_abnormal_cellular_cholesterol2.14699167
22MP0002118_abnormal_lipid_homeostasis2.05033438
23MP0004084_abnormal_cardiac_muscle2.03467453
24MP0003195_calcinosis2.03340405
25MP0000609_abnormal_liver_physiology2.03126343
26MP0004858_abnormal_nervous_system2.02751633
27MP0001849_ear_inflammation2.00450745
28MP0003453_abnormal_keratinocyte_physiol1.96526076
29MP0005058_abnormal_lysosome_morphology1.95770005
30MP0001666_abnormal_nutrient_absorption1.94050017
31MP0005330_cardiomyopathy1.85036806
32MP0005319_abnormal_enzyme/_coenzyme1.84797703
33MP0000751_myopathy1.80430940
34MP0005409_darkened_coat_color1.77853388
35MP0005501_abnormal_skin_physiology1.75637592
36MP0000678_abnormal_parathyroid_gland1.70010179
37MP0004185_abnormal_adipocyte_glucose1.63406983
38MP0006036_abnormal_mitochondrial_physio1.57396063
39MP0010352_gastrointestinal_tract_polyps1.57135617
40MP0004215_abnormal_myocardial_fiber1.56054994
41MP0001730_embryonic_growth_arrest1.55771366
42MP0000537_abnormal_urethra_morphology1.55009089
43MP0000733_abnormal_muscle_development1.51766000
44MP0004036_abnormal_muscle_relaxation1.51373540
45MP0004019_abnormal_vitamin_homeostasis1.48544603
46MP0005584_abnormal_enzyme/coenzyme_acti1.48081337
47MP0008260_abnormal_autophagy1.47853090
48MP0004087_abnormal_muscle_fiber1.46937937
49MP0003111_abnormal_nucleus_morphology1.46791039
50MP0002971_abnormal_brown_adipose1.46549668
51MP0002269_muscular_atrophy1.43582603
52MP0001348_abnormal_lacrimal_gland1.43480813
53MP0005375_adipose_tissue_phenotype1.40110825
54MP0000579_abnormal_nail_morphology1.35745764
55MP0004510_myositis1.34989865
56MP0009643_abnormal_urine_homeostasis1.33855296
57MP0002249_abnormal_larynx_morphology1.30281426
58MP0000749_muscle_degeneration1.28348516
59MP0010630_abnormal_cardiac_muscle1.28145236
60MP0004264_abnormal_extraembryonic_tissu1.28020940
61MP0008775_abnormal_heart_ventricle1.27287774
62MP0002089_abnormal_postnatal_growth/wei1.26612901
63MP0003693_abnormal_embryo_hatching1.25908872
64MP0002060_abnormal_skin_morphology1.24849186
65MP0000566_synostosis1.24716649
66MP0002138_abnormal_hepatobiliary_system1.24605980
67MP0003091_abnormal_cell_migration1.21355281
68MP0001544_abnormal_cardiovascular_syste1.20145193
69MP0005385_cardiovascular_system_phenoty1.20145193
70MP0000467_abnormal_esophagus_morphology1.18849243
71MP0006138_congestive_heart_failure1.14992578
72MP0005451_abnormal_body_composition1.13665415
73MP0001216_abnormal_epidermal_layer1.11997820
74MP0003221_abnormal_cardiomyocyte_apopto1.11901101
75MP0001764_abnormal_homeostasis1.10595209
76MP0000598_abnormal_liver_morphology1.10541438
77MP0005623_abnormal_meninges_morphology1.09492167
78MP0002972_abnormal_cardiac_muscle1.08609822
79MP0004947_skin_inflammation1.07142906
80MP0002078_abnormal_glucose_homeostasis1.06460309
81MP0005334_abnormal_fat_pad1.06025940
82MP0001873_stomach_inflammation1.05639936
83MP0004957_abnormal_blastocyst_morpholog1.04122721
84MP0000750_abnormal_muscle_regeneration1.01717109
85MP0000858_altered_metastatic_potential1.01367202
86MP0000747_muscle_weakness1.00939080
87MP0003186_abnormal_redox_activity0.99352287
88MP0005620_abnormal_muscle_contractility0.98756569
89MP0005257_abnormal_intraocular_pressure0.98332677
90MP0000350_abnormal_cell_proliferation0.96833762
91MP0003868_abnormal_feces_composition0.96735375
92MP0002098_abnormal_vibrissa_morphology0.96690073
93MP0005266_abnormal_metabolism0.96281976
94MP0008961_abnormal_basal_metabolism0.95746119
95MP0006035_abnormal_mitochondrial_morpho0.94705365
96MP0004782_abnormal_surfactant_physiolog0.94376402
97MP0003984_embryonic_growth_retardation0.94274917
98MP0004272_abnormal_basement_membrane0.93847212
99MP0002080_prenatal_lethality0.93736670
100MP0009115_abnormal_fat_cell0.93152715
101MP0010368_abnormal_lymphatic_system0.93045363
102MP0009333_abnormal_splenocyte_physiolog0.92447146
103MP0002970_abnormal_white_adipose0.91552541
104MP0005535_abnormal_body_temperature0.91246843
105MP0005023_abnormal_wound_healing0.90134725
106MP0003656_abnormal_erythrocyte_physiolo0.90007157
107MP0001672_abnormal_embryogenesis/_devel0.89529091
108MP0005380_embryogenesis_phenotype0.89529091
109MP0003077_abnormal_cell_cycle0.88415225
110MP0010094_abnormal_chromosome_stability0.88403990
111MP0002396_abnormal_hematopoietic_system0.88170641
112MP0002088_abnormal_embryonic_growth/wei0.86578215
113MP0009931_abnormal_skin_appearance0.85530305
114MP0002086_abnormal_extraembryonic_tissu0.84972879
115MP0003137_abnormal_impulse_conducting0.84337696
116MP0005621_abnormal_cell_physiology0.83581491
117MP0000762_abnormal_tongue_morphology0.82809256
118MP0009278_abnormal_bone_marrow0.82444743
119MP0003329_amyloid_beta_deposits0.80111914
120MP0001756_abnormal_urination0.79377008
121MP0000003_abnormal_adipose_tissue0.79153355
122MP0002106_abnormal_muscle_physiology0.78952516
123MP0009763_increased_sensitivity_to0.78272563
124MP0005448_abnormal_energy_balance0.77741397
125MP0000604_amyloidosis0.76050937
126MP0001661_extended_life_span0.75885552
127MP0000759_abnormal_skeletal_muscle0.75864624
128MP0003566_abnormal_cell_adhesion0.75639838
129MP0003300_gastrointestinal_ulcer0.75113816
130MP0004233_abnormal_muscle_weight0.74853670
131MP0002166_altered_tumor_susceptibility0.74554410
132MP0000377_abnormal_hair_follicle0.73665582
133MP0001915_intracranial_hemorrhage0.73520719
134MP0009642_abnormal_blood_homeostasis0.73280473
135MP0005647_abnormal_sex_gland0.73142409
136MP0010030_abnormal_orbit_morphology0.72725350
137MP0004808_abnormal_hematopoietic_stem0.71462491
138MP0004381_abnormal_hair_follicle0.70781835
139MP0001346_abnormal_lacrimal_gland0.70309108
140MP0005636_abnormal_mineral_homeostasis0.69811352
141MP0000490_abnormal_crypts_of0.69400618
142MP0004043_abnormal_pH_regulation0.68093952
143MP0005376_homeostasis/metabolism_phenot0.68024157
144MP0009672_abnormal_birth_weight0.66543970
145MP0008438_abnormal_cutaneous_collagen0.65437406
146MP0002254_reproductive_system_inflammat0.64467867
147MP0002332_abnormal_exercise_endurance0.61589881
148MP0004085_abnormal_heartbeat0.60363575
149MP0005369_muscle_phenotype0.59742002
150MP0000230_abnormal_systemic_arterial0.54366222
151MP0000266_abnormal_heart_morphology0.53368314
152MP0008469_abnormal_protein_level0.53347099
153MP0003828_pulmonary_edema0.53281344
154MP0002136_abnormal_kidney_physiology0.51410443
155MP0003953_abnormal_hormone_level0.49150655
156MP0002128_abnormal_blood_circulation0.49075655
157MP0000013_abnormal_adipose_tissue0.48594608
158MP0002127_abnormal_cardiovascular_syste0.47928983
159MP0003567_abnormal_fetal_cardiomyocyte0.47912998
160MP0004484_altered_response_of0.47736494
161MP0005452_abnormal_adipose_tissue0.47489265
162MP0002796_impaired_skin_barrier0.46406444

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.13514559
2Intrahepatic cholestasis (HP:0001406)4.97795085
3Xanthomatosis (HP:0000991)4.87275082
4Hypoglycemic coma (HP:0001325)4.69036041
5Hyperglycinuria (HP:0003108)4.63164135
6Hyperammonemia (HP:0001987)4.62778325
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.60223019
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.47749966
9Ketosis (HP:0001946)4.47163034
10Abnormality of glycine metabolism (HP:0010895)4.24744333
11Abnormality of serine family amino acid metabolism (HP:0010894)4.24744333
12Hypobetalipoproteinemia (HP:0003563)4.17113851
13Abnormality of fatty-acid metabolism (HP:0004359)4.02913278
14Ketoacidosis (HP:0001993)4.01315853
15Hyperlipoproteinemia (HP:0010980)3.95449437
16Hyperglycinemia (HP:0002154)3.91899843
17Myoglobinuria (HP:0002913)3.84719515
18Complement deficiency (HP:0004431)3.83117451
19Hypoalphalipoproteinemia (HP:0003233)3.82099309
20Hypolipoproteinemia (HP:0010981)3.77295389
21Prolonged partial thromboplastin time (HP:0003645)3.61750676
22Epidermoid cyst (HP:0200040)3.55482209
23Distal lower limb amyotrophy (HP:0008944)3.54480317
24Hyperacusis (HP:0010780)3.51489533
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.47504115
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.47231154
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39462532
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.36266638
29Dicarboxylic aciduria (HP:0003215)3.36266638
30Distal lower limb muscle weakness (HP:0009053)3.34966777
31Sudden death (HP:0001699)3.25886365
32Centrally nucleated skeletal muscle fibers (HP:0003687)3.25487280
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.19766617
34Rhabdomyolysis (HP:0003201)3.10383963
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.05636431
36Achilles tendon contracture (HP:0001771)3.00900166
37Myopathic facies (HP:0002058)3.00578941
38Abnormality of the common coagulation pathway (HP:0010990)2.94072723
39Skin nodule (HP:0200036)2.91967176
40Right ventricular cardiomyopathy (HP:0011663)2.90226456
41Ulnar bowing (HP:0003031)2.84624671
42Hypercholesterolemia (HP:0003124)2.80002477
43Abnormality of complement system (HP:0005339)2.79046573
44Exercise-induced myalgia (HP:0003738)2.78152908
45Gout (HP:0001997)2.74375928
46Metabolic acidosis (HP:0001942)2.73970456
47Ventricular tachycardia (HP:0004756)2.73559995
48Abnormality of methionine metabolism (HP:0010901)2.73459087
49Broad face (HP:0000283)2.72550375
50Abnormality of serum amino acid levels (HP:0003112)2.71954612
51Exercise-induced muscle cramps (HP:0003710)2.71301858
52Progressive muscle weakness (HP:0003323)2.69697597
53Joint hemorrhage (HP:0005261)2.69001998
54Dysmetric saccades (HP:0000641)2.67576639
55Increased connective tissue (HP:0009025)2.66902204
56Myocardial infarction (HP:0001658)2.65071992
57Abnormality of the intrinsic pathway (HP:0010989)2.61414153
58Abnormality of purine metabolism (HP:0004352)2.57590022
59Hyporeflexia of lower limbs (HP:0002600)2.52778727
60Abnormality of nucleobase metabolism (HP:0010932)2.52161300
61Generalized aminoaciduria (HP:0002909)2.52082643
62Fat malabsorption (HP:0002630)2.50304624
63Hyperinsulinemic hypoglycemia (HP:0000825)2.50301773
64Flat acetabular roof (HP:0003180)2.48520087
65Muscle fiber inclusion bodies (HP:0100299)2.45966613
66Cholelithiasis (HP:0001081)2.44925034
67Lethargy (HP:0001254)2.44312283
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43860138
69Hyperbilirubinemia (HP:0002904)2.42835555
70Mildly elevated creatine phosphokinase (HP:0008180)2.42198480
71Lower limb amyotrophy (HP:0007210)2.41964631
72Abnormality of pyrimidine metabolism (HP:0004353)2.41303855
73Hemorrhage of the eye (HP:0011885)2.40880429
74Type 1 muscle fiber predominance (HP:0003803)2.38756299
75Cerebral edema (HP:0002181)2.36136111
76Difficulty climbing stairs (HP:0003551)2.36070431
77Late onset (HP:0003584)2.35801591
78Atrioventricular block (HP:0001678)2.34810755
79Palpitations (HP:0001962)2.33907023
80Hypoglycemic seizures (HP:0002173)2.33666060
81Delayed CNS myelination (HP:0002188)2.31748044
82Trismus (HP:0000211)2.31650113
83Abnormal gallbladder morphology (HP:0012437)2.30956785
84Hepatocellular carcinoma (HP:0001402)2.30765809
85Abnormality of skeletal muscle fiber size (HP:0012084)2.29220064
86Muscle fiber splitting (HP:0003555)2.28695868
87Lipoatrophy (HP:0100578)2.28668701
88Nemaline bodies (HP:0003798)2.27530461
89Round ear (HP:0100830)2.27211123
90Nausea (HP:0002018)2.27130572
91Proximal tubulopathy (HP:0000114)2.25537541
92Cerebral aneurysm (HP:0004944)2.24202834
93Increased variability in muscle fiber diameter (HP:0003557)2.24066537
94Upper limb amyotrophy (HP:0009129)2.21929804
95Distal upper limb amyotrophy (HP:0007149)2.21929804
96Hyperglycemia (HP:0003074)2.21212153
97Neonatal onset (HP:0003623)2.20007314
98Asymmetric septal hypertrophy (HP:0001670)2.19586840
99Abnormal cartilage morphology (HP:0002763)2.18909125
100Ragged-red muscle fibers (HP:0003200)2.18413252
101Advanced eruption of teeth (HP:0006288)2.17086728
102Spastic diplegia (HP:0001264)2.16676726
103Vertebral compression fractures (HP:0002953)2.13983897
104Back pain (HP:0003418)2.13467339
105Increased purine levels (HP:0004368)2.11005275
106Hyperuricemia (HP:0002149)2.11005275
107Vomiting (HP:0002013)2.09730586
108Stridor (HP:0010307)2.09729005
109Lymphangioma (HP:0100764)2.09552971
110Protrusio acetabuli (HP:0003179)2.06141761
111Abnormality of proline metabolism (HP:0010907)2.04340566
112Hydroxyprolinuria (HP:0003080)2.04340566
113Hypertriglyceridemia (HP:0002155)2.04132545
114Thin bony cortex (HP:0002753)2.04095159
115Reticulocytosis (HP:0001923)2.04008632
116Asymmetry of the thorax (HP:0001555)2.03469474
117Difficulty running (HP:0009046)2.01667699
118Abnormality of the salivary glands (HP:0010286)2.01081844
119Obstructive sleep apnea (HP:0002870)2.00764144
120Dilated cardiomyopathy (HP:0001644)1.99968488
121Increased muscle lipid content (HP:0009058)1.99927046
122Spinal rigidity (HP:0003306)1.98257591
123Premature rupture of membranes (HP:0001788)1.97477227
124Insomnia (HP:0100785)1.96944897
125EMG: myopathic abnormalities (HP:0003458)1.96198809
126Bulbar palsy (HP:0001283)1.95296799
127Esophageal varix (HP:0002040)1.95289751
128Conjunctival hamartoma (HP:0100780)1.92789961
129Abnormality of the Achilles tendon (HP:0005109)1.92350333
130Heart block (HP:0012722)1.91670965
131Calf muscle hypertrophy (HP:0008981)1.90360873
132Bundle branch block (HP:0011710)1.89755398
133Progressive external ophthalmoplegia (HP:0000590)1.89295639
134Ventricular arrhythmia (HP:0004308)1.88312946
135Disproportionate tall stature (HP:0001519)1.88095119
136Conjugated hyperbilirubinemia (HP:0002908)1.87506333
137Sensorimotor neuropathy (HP:0007141)1.84701179
138Atrial fibrillation (HP:0005110)1.84686745
139Abnormal gallbladder physiology (HP:0012438)1.84208083
140Cholecystitis (HP:0001082)1.84208083
141Generalized amyotrophy (HP:0003700)1.84147173
142Abnormality of the distal phalanges of the toes (HP:0010182)1.84044802
143Long palpebral fissure (HP:0000637)1.83951853
144Fragile skin (HP:0001030)1.83790764
145Abnormality of the thoracic spine (HP:0100711)1.83551819
146Pancreatitis (HP:0001733)1.82640579
147Multiple enchondromatosis (HP:0005701)1.82523852
148Hepatic necrosis (HP:0002605)1.81701075
149Ankyloglossia (HP:0010296)1.76863838
150Foot dorsiflexor weakness (HP:0009027)1.74287730
151Deviation of the thumb (HP:0009603)1.72968654
152Short nail (HP:0001799)1.71854706
153Selective tooth agenesis (HP:0001592)1.71459521
154Sparse lateral eyebrow (HP:0005338)1.70550415
155Neck muscle weakness (HP:0000467)1.70095041
156Acanthosis nigricans (HP:0000956)1.69463515
157Elbow flexion contracture (HP:0002987)1.66945223
158Muscle stiffness (HP:0003552)1.64405487
159Septate vagina (HP:0001153)1.63698378
160Easy fatigability (HP:0003388)1.63522632
161Abnormality of glycolysis (HP:0004366)1.63195381
162Abnormality of the calcaneus (HP:0008364)1.62901433
163Shallow orbits (HP:0000586)1.61803979
164Ridged nail (HP:0001807)1.60593440
165Natal tooth (HP:0000695)1.60272105
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.59726814
167Cerebral inclusion bodies (HP:0100314)1.58086572
168Neonatal death (HP:0003811)1.58028595
169Hyperparathyroidism (HP:0000843)1.56671632
170Metaphyseal cupping (HP:0003021)1.56487613
171Proximal placement of thumb (HP:0009623)1.56450720
172Termporal pattern (HP:0011008)1.55510865
173Insidious onset (HP:0003587)1.55510865
174Abnormality of the foot musculature (HP:0001436)1.55432916
175Abnormality of carpal bone ossification (HP:0006257)1.54035405
176Osteolytic defects of the phalanges of the hand (HP:0009771)1.53734325
177Osteolytic defects of the hand bones (HP:0009699)1.53734325
178Abnormality of the fingertips (HP:0001211)1.53573148
179Abnormality of the tricuspid valve (HP:0001702)1.53272411
180Diaphragmatic weakness (HP:0009113)1.52180882
181Ulnar deviation of the wrist (HP:0003049)1.51521734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.95765418
2BCKDK4.90111934
3PKN24.24178659
4SMG14.16043602
5SIK13.33734350
6TTN3.01303138
7IRAK32.98589291
8ERN12.87255550
9PRPF4B2.77611590
10PDK42.73929950
11PDK32.73929950
12EPHA22.47130365
13FGFR42.41076091
14NME22.19581988
15LMTK22.17865885
16NEK12.06648292
17CAMK1D1.91474939
18RIPK11.79159498
19INSRR1.62655396
20OBSCN1.60355649
21MAP3K101.60115428
22EEF2K1.58492728
23PTK61.51301614
24FLT31.49034234
25MAP3K71.46754236
26PHKG21.43131685
27PHKG11.43131685
28MAP2K31.41981968
29PDK21.37141755
30LATS11.34100807
31RPS6KB21.28185854
32CAMK1G1.28151380
33MAPK111.24786292
34PRKAA21.19907852
35ICK1.19847200
36MTOR1.09485031
37CDK121.09055002
38MYLK1.06132810
39PDGFRA1.05981123
40PAK41.05771577
41PRKAA11.03369725
42MAP3K31.01717684
43ARAF1.00984347
44MST1R0.99516740
45PINK10.98886009
46MAP3K130.95105874
47CDK40.90025290
48CDK70.89199998
49MAP2K40.88003286
50DMPK0.87283332
51ERBB40.84097246
52TESK10.83903306
53PIM20.82597758
54MAP3K110.80387478
55JAK20.79459077
56TAOK10.75606433
57CDK60.73325101
58NEK90.72671159
59TIE10.72189932
60EPHB10.71554914
61PIK3CA0.70551888
62IRAK20.68687899
63RET0.67610429
64PRKD10.66256567
65TAOK30.65997113
66MAP3K50.65977841
67WNK40.65550382
68BMX0.65503524
69PDPK10.65412210
70BRAF0.64728232
71PRKD20.64212673
72STK38L0.63606540
73MAP3K90.63400634
74MARK20.63216399
75MAPKAPK30.62866073
76RPS6KA20.61876040
77KDR0.61384586
78JAK10.60920322
79MAPK120.60538063
80PRKACG0.60314439
81SGK30.59821006
82MAP2K20.59000594
83LRRK20.58629447
84PAK30.57167152
85PRKD30.57158213
86TESK20.56810275
87PDK10.56755176
88TYK20.56674405
89LATS20.55704875
90FGFR30.55547667
91STK380.53778281
92ALK0.50389307
93TGFBR20.50322314
94PAK20.49230084
95PIK3CG0.46967464
96CDK90.46876776
97MAP3K60.46833284
98PRKCH0.46828172
99MAP4K10.46026128
100AKT20.45554639
101CAMK40.45068490
102FGFR10.44950947
103GSK3A0.44480683
104AURKA0.43787697
105MAP3K140.43114376
106PRKG20.41581261
107MAP2K10.41220970
108ILK0.40948530
109CHEK10.40827608
110TBK10.39988085
111TRPM70.39725674
112NTRK10.39622851
113PRKCI0.39465795
114CDK80.39208847
115MET0.38897229
116CDC42BPA0.38590898
117PTK20.38081903
118ABL20.37276462
119KSR20.37161947
120TTK0.35203388
121SCYL20.35102737
122BUB10.35032741
123DDR20.34778902
124FGFR20.33527203
125DAPK20.33273383
126RPS6KA10.33083309
127BRD40.32888397
128GRK60.32789827
129TAOK20.32651328
130SIK20.32583249
131ERBB20.32344646
132HIPK20.31815255
133MAP3K10.31117673
134RPS6KA60.30905118
135MAP3K80.30805050
136TSSK60.30207895
137FRK0.29984103
138RPS6KL10.29534034
139RPS6KC10.29534034
140CDK20.29254747
141TYRO30.28918060
142MAPK100.28866561

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.62431932
2Nitrogen metabolism_Homo sapiens_hsa009103.39845292
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.28508180
4Fatty acid degradation_Homo sapiens_hsa000713.21502313
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.17789810
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.97962722
7Propanoate metabolism_Homo sapiens_hsa006402.97548592
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.96563895
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.88627589
10Arginine biosynthesis_Homo sapiens_hsa002202.79579961
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68186634
12Fatty acid metabolism_Homo sapiens_hsa012122.53649477
13Tryptophan metabolism_Homo sapiens_hsa003802.45511070
14PPAR signaling pathway_Homo sapiens_hsa033202.31827229
15Butanoate metabolism_Homo sapiens_hsa006502.25273261
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15623828
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10269546
18Carbon metabolism_Homo sapiens_hsa012002.06597499
19Pyruvate metabolism_Homo sapiens_hsa006201.96886297
20Complement and coagulation cascades_Homo sapiens_hsa046101.84851549
21Peroxisome_Homo sapiens_hsa041461.83162751
22beta-Alanine metabolism_Homo sapiens_hsa004101.79561945
23Other glycan degradation_Homo sapiens_hsa005111.72845147
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71373757
25Biosynthesis of amino acids_Homo sapiens_hsa012301.68077330
26Chronic myeloid leukemia_Homo sapiens_hsa052201.66258086
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65270222
28Selenocompound metabolism_Homo sapiens_hsa004501.44583663
29Phenylalanine metabolism_Homo sapiens_hsa003601.39028326
30Starch and sucrose metabolism_Homo sapiens_hsa005001.38758408
31Bile secretion_Homo sapiens_hsa049761.37283958
32Non-small cell lung cancer_Homo sapiens_hsa052231.35921084
33Fatty acid biosynthesis_Homo sapiens_hsa000611.32542117
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30753667
35Lysine degradation_Homo sapiens_hsa003101.30496649
36Caffeine metabolism_Homo sapiens_hsa002321.29958313
37Thyroid cancer_Homo sapiens_hsa052161.29595690
38Notch signaling pathway_Homo sapiens_hsa043301.27986292
39Fat digestion and absorption_Homo sapiens_hsa049751.26980305
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26851904
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.26582797
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24784907
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.24424232
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24392302
45DNA replication_Homo sapiens_hsa030301.23091038
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20745764
47VEGF signaling pathway_Homo sapiens_hsa043701.20257201
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19810273
49Chemical carcinogenesis_Homo sapiens_hsa052041.17522605
50Fatty acid elongation_Homo sapiens_hsa000621.16961884
51Histidine metabolism_Homo sapiens_hsa003401.15230853
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15190442
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.11801832
54Tyrosine metabolism_Homo sapiens_hsa003501.10539273
55Endometrial cancer_Homo sapiens_hsa052131.09106995
56Pancreatic cancer_Homo sapiens_hsa052121.07839784
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.04669425
58Staphylococcus aureus infection_Homo sapiens_hsa051501.02961536
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01194376
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98393803
61ABC transporters_Homo sapiens_hsa020100.97342274
62Retinol metabolism_Homo sapiens_hsa008300.96983800
63Glycerolipid metabolism_Homo sapiens_hsa005610.96530326
64Small cell lung cancer_Homo sapiens_hsa052220.96393414
65Glioma_Homo sapiens_hsa052140.92827748
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89556967
67Arginine and proline metabolism_Homo sapiens_hsa003300.89343623
68One carbon pool by folate_Homo sapiens_hsa006700.83812188
69Sulfur metabolism_Homo sapiens_hsa009200.80870204
70ErbB signaling pathway_Homo sapiens_hsa040120.79252093
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.79036034
72Pentose phosphate pathway_Homo sapiens_hsa000300.78246196
73Focal adhesion_Homo sapiens_hsa045100.77913803
74Insulin resistance_Homo sapiens_hsa049310.77549601
75Sulfur relay system_Homo sapiens_hsa041220.75007985
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74527602
77Folate biosynthesis_Homo sapiens_hsa007900.73971561
78Renal cell carcinoma_Homo sapiens_hsa052110.73850451
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.70676009
80Prostate cancer_Homo sapiens_hsa052150.69694108
81Proteoglycans in cancer_Homo sapiens_hsa052050.69274540
82Adherens junction_Homo sapiens_hsa045200.67917083
83Vitamin B6 metabolism_Homo sapiens_hsa007500.66854000
84MicroRNAs in cancer_Homo sapiens_hsa052060.66795461
85GnRH signaling pathway_Homo sapiens_hsa049120.66238668
86Vitamin digestion and absorption_Homo sapiens_hsa049770.63104714
87Glucagon signaling pathway_Homo sapiens_hsa049220.59993924
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59545081
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58710406
90Fructose and mannose metabolism_Homo sapiens_hsa000510.58388876
91mRNA surveillance pathway_Homo sapiens_hsa030150.58372806
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58185908
93AMPK signaling pathway_Homo sapiens_hsa041520.57972331
94B cell receptor signaling pathway_Homo sapiens_hsa046620.57933927
95Hepatitis C_Homo sapiens_hsa051600.57677111
96Galactose metabolism_Homo sapiens_hsa000520.52714480
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52535417
98Apoptosis_Homo sapiens_hsa042100.52427912
99Viral carcinogenesis_Homo sapiens_hsa052030.52156006
100Cell cycle_Homo sapiens_hsa041100.51755081
101Estrogen signaling pathway_Homo sapiens_hsa049150.49836047
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.49746821
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48548453
104Glutathione metabolism_Homo sapiens_hsa004800.48237028
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.47235526
106Base excision repair_Homo sapiens_hsa034100.46500242
107Insulin signaling pathway_Homo sapiens_hsa049100.44914156
108Inositol phosphate metabolism_Homo sapiens_hsa005620.44484461
109HTLV-I infection_Homo sapiens_hsa051660.44085320
110N-Glycan biosynthesis_Homo sapiens_hsa005100.41884465
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41631952
112Choline metabolism in cancer_Homo sapiens_hsa052310.40497509
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40085718
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39961476
115ECM-receptor interaction_Homo sapiens_hsa045120.38871731
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38257636
117Metabolic pathways_Homo sapiens_hsa011000.37463146
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36639566
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.34918850
120Dilated cardiomyopathy_Homo sapiens_hsa054140.32982767
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30424747
122Cardiac muscle contraction_Homo sapiens_hsa042600.26295276
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24488519
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18131792
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17374078
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17264962
127Steroid biosynthesis_Homo sapiens_hsa001000.16054721
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.13395765
129Prion diseases_Homo sapiens_hsa050200.11765418
130Type II diabetes mellitus_Homo sapiens_hsa049300.08874521
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.08150124
132mTOR signaling pathway_Homo sapiens_hsa041500.04331840
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01334269
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00897075
135Acute myeloid leukemia_Homo sapiens_hsa05221-0.0995001
136Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0895413
137Bladder cancer_Homo sapiens_hsa05219-0.0882181
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0832032
139Renin-angiotensin system_Homo sapiens_hsa04614-0.0707699
140Amoebiasis_Homo sapiens_hsa05146-0.0681108
141Protein digestion and absorption_Homo sapiens_hsa04974-0.0394275
142HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0377516
143Viral myocarditis_Homo sapiens_hsa05416-0.0178943
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0061154

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