CLUHP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.34688387
2response to interleukin-15 (GO:0070672)5.26830659
3positive regulation of gamma-delta T cell activation (GO:0046645)5.21620709
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.11088267
5negative T cell selection (GO:0043383)5.05110863
6negative regulation of cell killing (GO:0031342)5.04529825
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04529825
8negative thymic T cell selection (GO:0045060)5.03476842
9antigen processing and presentation of endogenous antigen (GO:0019883)4.84173170
10cellular response to interleukin-15 (GO:0071350)4.77426699
11regulation of gamma-delta T cell differentiation (GO:0045586)4.77299432
12regulation of gamma-delta T cell activation (GO:0046643)4.65986367
13positive T cell selection (GO:0043368)4.38275499
14thymic T cell selection (GO:0045061)4.31132045
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.27091873
16tolerance induction (GO:0002507)4.24546624
17histone H3-K36 demethylation (GO:0070544)4.20528181
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19325817
19T cell selection (GO:0045058)4.15598167
20regulation of B cell receptor signaling pathway (GO:0050855)4.09436978
21positive thymic T cell selection (GO:0045059)4.02014841
22positive regulation of granulocyte differentiation (GO:0030854)3.89001493
23B cell receptor signaling pathway (GO:0050853)3.75851934
24histone H3-K4 trimethylation (GO:0080182)3.64594650
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.60559960
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.58875011
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.57823495
28activated T cell proliferation (GO:0050798)3.52808401
29CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.51793297
30T cell migration (GO:0072678)3.51571183
31interferon-gamma production (GO:0032609)3.47155952
32negative regulation of T cell mediated immunity (GO:0002710)3.40573540
33positive regulation of CREB transcription factor activity (GO:0032793)3.24081450
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22557211
35regulation of histone H3-K27 methylation (GO:0061085)3.18316504
36positive regulation of B cell differentiation (GO:0045579)3.16247960
37regulation of alpha-beta T cell proliferation (GO:0046640)3.08448072
38mannose metabolic process (GO:0006013)3.07774846
39regulation of B cell differentiation (GO:0045577)3.06270650
40antigen receptor-mediated signaling pathway (GO:0050851)3.02146570
41diacylglycerol metabolic process (GO:0046339)2.98922244
42negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.98219847
43response to type I interferon (GO:0034340)2.97484129
44B cell homeostasis (GO:0001782)2.95283514
45plasma lipoprotein particle assembly (GO:0034377)2.94105771
46negative regulation of B cell mediated immunity (GO:0002713)2.89396158
47negative regulation of immunoglobulin mediated immune response (GO:0002890)2.89396158
48regulation of regulatory T cell differentiation (GO:0045589)2.89285371
49regulation of interleukin-2 biosynthetic process (GO:0045076)2.88592612
50type I interferon signaling pathway (GO:0060337)2.87773062
51cellular response to type I interferon (GO:0071357)2.87773062
52negative regulation of leukocyte mediated immunity (GO:0002704)2.86136618
53interferon-gamma secretion (GO:0072643)2.85855646
54T cell receptor signaling pathway (GO:0050852)2.84904869
55leukocyte aggregation (GO:0070486)2.81954502
56phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.81893102
57histone H3-K4 methylation (GO:0051568)2.80475800
58regulation of T cell tolerance induction (GO:0002664)2.79664284
59negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.78510658
60negative regulation of fibrinolysis (GO:0051918)2.77638952
61positive regulation of humoral immune response (GO:0002922)2.77075669
62regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.76787608
63regulation of natural killer cell mediated immunity (GO:0002715)2.76787608
64regulation of isotype switching to IgG isotypes (GO:0048302)2.72804189
65regulation of T cell mediated cytotoxicity (GO:0001914)2.72240217
66regulation of granulocyte differentiation (GO:0030852)2.71290806
67response to muramyl dipeptide (GO:0032495)2.68101831
68detection of bacterium (GO:0016045)2.66799572
69NIK/NF-kappaB signaling (GO:0038061)2.65921734
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65808471
71mucosal-associated lymphoid tissue development (GO:0048537)2.65555881
72Peyers patch development (GO:0048541)2.65555881
73negative regulation of protein oligomerization (GO:0032460)2.65430385
74intestinal cholesterol absorption (GO:0030299)2.64903413
75regulation of fibrinolysis (GO:0051917)2.64531352
76negative regulation of innate immune response (GO:0045824)2.64494773
77high-density lipoprotein particle remodeling (GO:0034375)2.63096177
78negative regulation of adaptive immune response (GO:0002820)2.62908312
79histone H4-K16 acetylation (GO:0043984)2.62864206
80T cell homeostasis (GO:0043029)2.60335581
81lymphocyte homeostasis (GO:0002260)2.59113646
82antigen processing and presentation via MHC class Ib (GO:0002475)2.58934442
83positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58925238
84positive regulation by host of viral transcription (GO:0043923)2.57807938
85protein-lipid complex assembly (GO:0065005)2.56137522
86cellular response to ethanol (GO:0071361)2.55917584
87alpha-beta T cell differentiation (GO:0046632)2.55860210
88T cell lineage commitment (GO:0002360)2.53769467
89negative regulation of calcium ion transport into cytosol (GO:0010523)2.50681168
90negative regulation of cAMP-mediated signaling (GO:0043951)2.50054802
91zinc ion homeostasis (GO:0055069)2.48481839
92positive regulation of tolerance induction (GO:0002645)2.46859629
93positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.44484462
94positive regulation of interleukin-2 production (GO:0032743)2.44014809
95regulation of leukocyte mediated cytotoxicity (GO:0001910)2.43704141
96negative regulation of bone resorption (GO:0045779)2.43244807
97negative regulation of T-helper cell differentiation (GO:0045623)2.42869680
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.42869680
99histone lysine demethylation (GO:0070076)2.41312441
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40781729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.45264217
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.96128000
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.82464198
4MYC_22102868_ChIP-Seq_BL_Human3.51843256
5RUNX_20019798_ChIP-Seq_JUKART_Human3.14025135
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90143199
7E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.81602806
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.73264850
9MYB_26560356_Chip-Seq_TH2_Human2.68019381
10MAF_26560356_Chip-Seq_TH1_Human2.62376032
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.50366801
12MYB_26560356_Chip-Seq_TH1_Human2.47905077
13CIITA_25753668_ChIP-Seq_RAJI_Human2.47608722
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47060448
15UTX_26944678_Chip-Seq_JUKART_Human2.30410503
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29536281
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.28612483
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27216796
19VDR_21846776_ChIP-Seq_THP-1_Human2.26144294
20MAF_26560356_Chip-Seq_TH2_Human2.23848785
21TCF7_22412390_ChIP-Seq_EML_Mouse2.15624123
22GATA3_27048872_Chip-Seq_THYMUS_Human2.00311146
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99742999
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95859852
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93122118
26KDM2B_26808549_Chip-Seq_DND41_Human1.79645171
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78778378
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76092292
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66097083
30SCL_19346495_ChIP-Seq_HPC-7_Human1.65083751
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.63115118
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62807173
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61459995
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57657688
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56567244
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.55461347
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52838425
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47942677
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.47054099
40GATA3_26560356_Chip-Seq_TH2_Human1.46854814
41VDR_24763502_ChIP-Seq_THP-1_Human1.46671697
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46552850
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46408791
44SPI1_23127762_ChIP-Seq_K562_Human1.46085432
45BCOR_27268052_Chip-Seq_Bcells_Human1.42067867
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39434075
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36695155
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.34963368
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.33894178
50BCL6_27268052_Chip-Seq_Bcells_Human1.33733398
51P68_20966046_ChIP-Seq_HELA_Human1.31226151
52SPI1_23547873_ChIP-Seq_NB4_Human1.30981604
53SMC4_20622854_ChIP-Seq_HELA_Human1.30418063
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27573269
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27361113
56LXR_22292898_ChIP-Seq_THP-1_Human1.26518488
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.24871186
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24050714
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.23937394
60DROSHA_22980978_ChIP-Seq_HELA_Human1.22568904
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.20915116
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20289066
63KDM5A_27292631_Chip-Seq_BREAST_Human1.20265404
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.18243564
65RARB_24833708_ChIP-Seq_LIVER_Mouse1.18016615
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15657322
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14445393
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12787764
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12587182
70PHF8_20622854_ChIP-Seq_HELA_Human1.12342855
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.11639523
72P300_27268052_Chip-Seq_Bcells_Human1.11265767
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10919724
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.10609228
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10505156
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09882227
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07187667
78E2F1_20622854_ChIP-Seq_HELA_Human1.07091298
79CREB1_26743006_Chip-Seq_LNCaP_Human1.05777862
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05126228
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04625950
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04620405
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04530343
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03469496
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02365301
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02068516
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00513998
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98512595
89GATA1_22025678_ChIP-Seq_K562_Human0.98137292
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96149155
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95863550
92RAC3_21632823_ChIP-Seq_H3396_Human0.95172373
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94770690
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94672587
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94606364
96ERA_21632823_ChIP-Seq_H3396_Human0.93889321
97OCT4_19829295_ChIP-Seq_ESCs_Human0.93264748
98GATA1_19941826_ChIP-Seq_K562_Human0.92187777
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90882155
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89996785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.32331808
2MP0005671_abnormal_response_to3.03730623
3MP0000685_abnormal_immune_system2.99415768
4MP0001800_abnormal_humoral_immune2.90718000
5MP0003436_decreased_susceptibility_to2.69791750
6MP0002138_abnormal_hepatobiliary_system2.56765147
7MP0001873_stomach_inflammation2.52889243
8MP0004381_abnormal_hair_follicle2.48923176
9MP0001835_abnormal_antigen_presentation2.45074723
10MP0001790_abnormal_immune_system2.44033521
11MP0005387_immune_system_phenotype2.44033521
12MP0005000_abnormal_immune_tolerance2.17196707
13MP0002166_altered_tumor_susceptibility2.15630930
14MP0002723_abnormal_immune_serum2.11632546
15MP0003866_abnormal_defecation2.06427593
16MP0009333_abnormal_splenocyte_physiolog2.01876373
17MP0002139_abnormal_hepatobiliary_system2.00933707
18MP0002420_abnormal_adaptive_immunity2.00752224
19MP0002398_abnormal_bone_marrow2.00676384
20MP0001819_abnormal_immune_cell1.98161104
21MP0000703_abnormal_thymus_morphology1.94470434
22MP0008057_abnormal_DNA_replication1.89847837
23MP0005360_urolithiasis1.89685248
24MP0003172_abnormal_lysosome_physiology1.89608197
25MP0002452_abnormal_antigen_presenting1.84931047
26MP0002405_respiratory_system_inflammati1.84788856
27MP0000716_abnormal_immune_system1.84630905
28MP0005025_abnormal_response_to1.83156533
29MP0001986_abnormal_taste_sensitivity1.82399073
30MP0005075_abnormal_melanosome_morpholog1.81520241
31MP0003195_calcinosis1.78746121
32MP0010329_abnormal_lipoprotein_level1.76145832
33MP0000689_abnormal_spleen_morphology1.75268391
34MP0002396_abnormal_hematopoietic_system1.72358116
35MP0005310_abnormal_salivary_gland1.71849859
36MP0005365_abnormal_bile_salt1.62745794
37MP0010155_abnormal_intestine_physiology1.61539414
38MP0002722_abnormal_immune_system1.60911571
39MP0004264_abnormal_extraembryonic_tissu1.52756592
40MP0002254_reproductive_system_inflammat1.51166710
41MP0002429_abnormal_blood_cell1.45916171
42MP0002009_preneoplasia1.43122575
43MP0003122_maternal_imprinting1.42097346
44MP0005451_abnormal_body_composition1.38034237
45MP0002006_tumorigenesis1.37259319
46MP0003724_increased_susceptibility_to1.36858889
47MP0004947_skin_inflammation1.36670964
48MP0001348_abnormal_lacrimal_gland1.32444973
49MP0002132_abnormal_respiratory_system1.30834418
50MP0009785_altered_susceptibility_to1.30680665
51MP0008961_abnormal_basal_metabolism1.28667404
52MP0001666_abnormal_nutrient_absorption1.27684774
53MP0002419_abnormal_innate_immunity1.26811754
54MP0001845_abnormal_inflammatory_respons1.23798100
55MP0003252_abnormal_bile_duct1.21686786
56MP0002693_abnormal_pancreas_physiology1.21109297
57MP0000609_abnormal_liver_physiology1.18223824
58MP0004043_abnormal_pH_regulation1.16533689
59MP0003303_peritoneal_inflammation1.11769818
60MP0005645_abnormal_hypothalamus_physiol1.08187530
61MP0003787_abnormal_imprinting1.07468753
62MP0003868_abnormal_feces_composition1.03610787
63MP0009840_abnormal_foam_cell1.03078609
64MP0003045_fibrosis1.01594008
65MP0003300_gastrointestinal_ulcer0.99421552
66MP0005085_abnormal_gallbladder_physiolo0.98783297
67MP0008875_abnormal_xenobiotic_pharmacok0.97648709
68MP0003183_abnormal_peptide_metabolism0.94957010
69MP0002928_abnormal_bile_duct0.94908399
70MP0008469_abnormal_protein_level0.94777376
71MP0005220_abnormal_exocrine_pancreas0.93332670
72MP0008260_abnormal_autophagy0.93070657
73MP0003656_abnormal_erythrocyte_physiolo0.92192679
74MP0000015_abnormal_ear_pigmentation0.91538648
75MP0002933_joint_inflammation0.90779614
76MP0001270_distended_abdomen0.88732069
77MP0002118_abnormal_lipid_homeostasis0.87453568
78MP0005448_abnormal_energy_balance0.85423953
79MP0008872_abnormal_physiological_respon0.84373833
80MP0001944_abnormal_pancreas_morphology0.82988153
81MP0002163_abnormal_gland_morphology0.80342961
82MP0005464_abnormal_platelet_physiology0.80044258
83MP0002822_catalepsy0.79559187
84MP0005076_abnormal_cell_differentiation0.79471953
85MP0003943_abnormal_hepatobiliary_system0.79380933
86MP0008995_early_reproductive_senescence0.78959692
87MP0002078_abnormal_glucose_homeostasis0.78435951
88MP0009115_abnormal_fat_cell0.75510498
89MP0005379_endocrine/exocrine_gland_phen0.75132231
90MP0008877_abnormal_DNA_methylation0.74913021
91MP0005083_abnormal_biliary_tract0.73375357
92MP0001765_abnormal_ion_homeostasis0.72630065
93MP0009642_abnormal_blood_homeostasis0.71619190
94MP0005423_abnormal_somatic_nervous0.71045811
95MP0004742_abnormal_vestibular_system0.70640093
96MP0001764_abnormal_homeostasis0.70628286
97MP0009643_abnormal_urine_homeostasis0.69673325
98MP0005174_abnormal_tail_pigmentation0.68179832
99MP0002019_abnormal_tumor_incidence0.67934535
100MP0002970_abnormal_white_adipose0.66464575

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.17526033
2Panhypogammaglobulinemia (HP:0003139)4.02152315
3Abnormal delayed hypersensitivity skin test (HP:0002963)3.88323108
4Abnormality of the fingertips (HP:0001211)3.61751704
5Colitis (HP:0002583)3.56978420
6Recurrent fungal infections (HP:0002841)3.54168225
7Prolonged partial thromboplastin time (HP:0003645)3.52659356
8Agammaglobulinemia (HP:0004432)3.38590073
9Chronic mucocutaneous candidiasis (HP:0002728)3.34444415
10Recurrent cutaneous fungal infections (HP:0011370)3.34444415
11Eczematoid dermatitis (HP:0000976)3.26644329
12Pustule (HP:0200039)3.25768371
13Myositis (HP:0100614)3.18484630
14Retrobulbar optic neuritis (HP:0100654)3.12400854
15Optic neuritis (HP:0100653)3.12400854
16Inflammation of the large intestine (HP:0002037)3.10558149
17Elevated erythrocyte sedimentation rate (HP:0003565)3.05239587
18Severe combined immunodeficiency (HP:0004430)3.02361137
19Meningitis (HP:0001287)3.02348492
20Gastrointestinal inflammation (HP:0004386)3.00835793
21Hypochromic anemia (HP:0001931)2.98486004
22Joint hemorrhage (HP:0005261)2.95549023
23T lymphocytopenia (HP:0005403)2.93963840
24Vasculitis (HP:0002633)2.91902783
25Abnormality of T cells (HP:0002843)2.88466417
26Abnormality of T cell number (HP:0011839)2.87517627
27Hypobetalipoproteinemia (HP:0003563)2.86392260
28Gastrointestinal infarctions (HP:0005244)2.86345820
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79551622
30Orchitis (HP:0100796)2.78172189
31Increased IgE level (HP:0003212)2.72913643
32Recurrent viral infections (HP:0004429)2.70259814
33Stomatitis (HP:0010280)2.69777909
34Chronic diarrhea (HP:0002028)2.69512265
35Recurrent bronchitis (HP:0002837)2.65645663
36Seborrheic dermatitis (HP:0001051)2.64667726
37Joint swelling (HP:0001386)2.62280869
38Recurrent skin infections (HP:0001581)2.59822731
39Recurrent sinusitis (HP:0011108)2.58059822
40Abnormality of T cell physiology (HP:0011840)2.55202643
41Encephalitis (HP:0002383)2.54446626
42Pigmentary retinal degeneration (HP:0001146)2.51021833
43Abnormality of eosinophils (HP:0001879)2.47546263
44Lymphopenia (HP:0001888)2.45452983
45Basal cell carcinoma (HP:0002671)2.44485131
46Mediastinal lymphadenopathy (HP:0100721)2.40132769
47Acute hepatic failure (HP:0006554)2.39857810
48Hemorrhage of the eye (HP:0011885)2.38635385
49Prolonged bleeding time (HP:0003010)2.35488851
50IgG deficiency (HP:0004315)2.34796489
51Granulocytopenia (HP:0001913)2.30986995
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.27888552
53Verrucae (HP:0200043)2.27225268
54Papilloma (HP:0012740)2.27225268
55Autoimmune hemolytic anemia (HP:0001890)2.24191009
56Clumsiness (HP:0002312)2.22448300
57Gingival bleeding (HP:0000225)2.21982786
58Recurrent bacterial skin infections (HP:0005406)2.21263378
59Hyperventilation (HP:0002883)2.18133206
60Keratoconjunctivitis (HP:0001096)2.17146876
61Abnormality of small intestinal villus morphology (HP:0011472)2.15343635
62Villous atrophy (HP:0011473)2.15343635
63Hepatitis (HP:0012115)2.15197844
64Gastrointestinal stroma tumor (HP:0100723)2.11908311
65Recurrent abscess formation (HP:0002722)2.08321990
66Pulmonary infiltrates (HP:0002113)2.07432327
67Keratoconjunctivitis sicca (HP:0001097)2.01539465
68Stomach cancer (HP:0012126)2.00146087
69Xanthomatosis (HP:0000991)1.99488212
70Abnormality of the nasal septum (HP:0000419)1.99311957
71Neoplasm of the tracheobronchial system (HP:0100552)1.98579246
72Eosinophilia (HP:0001880)1.98421829
73Abnormality of the common coagulation pathway (HP:0010990)1.97968685
74Pulmonary embolism (HP:0002204)1.97230780
75Viral hepatitis (HP:0006562)1.93934767
76Thyroiditis (HP:0100646)1.92137240
77Broad alveolar ridges (HP:0000187)1.91662575
78Alveolar cell carcinoma (HP:0006519)1.91549074
79Combined immunodeficiency (HP:0005387)1.89730225
80Abnormality of the pleura (HP:0002103)1.89711216
81Recurrent gram-negative bacterial infections (HP:0005420)1.87286348
82Menstrual irregularities (HP:0000858)1.86547779
83Leukocytosis (HP:0001974)1.86008643
84Hypoplasia of the thymus (HP:0000778)1.84617238
85Keratitis (HP:0000491)1.81743652
86Fair hair (HP:0002286)1.81161280
87IgM deficiency (HP:0002850)1.80539127
88Epistaxis (HP:0000421)1.77712608
89Menorrhagia (HP:0000132)1.73185585
90Anal stenosis (HP:0002025)1.73179735
91Squamous cell carcinoma (HP:0002860)1.72797503
92Hypochromic microcytic anemia (HP:0004840)1.71735529
93Gingivitis (HP:0000230)1.71654927
94Tapered finger (HP:0001182)1.71177556
95Abnormality of the columella (HP:0009929)1.68619131
96Hemoptysis (HP:0002105)1.68556474
97IgA deficiency (HP:0002720)1.68264624
98Ureteral stenosis (HP:0000071)1.68170459
99Chronic otitis media (HP:0000389)1.67578483
100Hyperlipoproteinemia (HP:0010980)1.67495584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.18310231
2FGFR43.62880597
3CDK122.84250630
4SIK22.80783568
5TXK2.51407130
6FGFR32.47228403
7TRIB32.17003072
8ITK1.98014200
9GRK61.88127243
10TYK21.86308432
11IKBKE1.80797039
12RIPK41.71699892
13BTK1.64419369
14TNK21.63368399
15PKN21.60205827
16ICK1.58767364
17MAP2K31.57165330
18PRPF4B1.56751023
19TAOK31.54593216
20JAK11.53560975
21JAK31.50554313
22MAP3K101.49776342
23MAPK111.48708189
24FGFR21.42650702
25ZAP701.40809399
26FRK1.40535601
27EPHA31.40417012
28HIPK21.39839170
29NLK1.36921955
30MAP3K141.34924702
31SYK1.33778268
32SIK11.28981775
33EEF2K1.27549273
34IRAK41.25378745
35PASK1.21954751
36BLK1.18546597
37CAMKK11.18511438
38ERN11.18045976
39MAP3K71.16267901
40IKBKB1.12294667
41BRD41.10532403
42LCK1.10290533
43HCK1.10218276
44SGK21.08955334
45CHUK1.07527882
46MAP2K61.05729697
47TYRO31.01430151
48MAP3K130.98076167
49AKT30.97752358
50PDK10.97091181
51CAMKK20.97072738
52SGK30.94826508
53WNK40.92057064
54WNK10.91911489
55CDC42BPA0.89882819
56PRKCQ0.89606150
57SMG10.89365716
58CDK40.87584371
59IRAK10.84099522
60MARK20.83667432
61RET0.82263302
62FES0.81709382
63TEC0.81674015
64SGK4940.80563455
65SGK2230.80563455
66LYN0.79453569
67MAPK120.77752303
68EPHB10.76953998
69TBK10.71678879
70NEK60.71046848
71CSK0.70197328
72MARK30.69519074
73PRKD20.68638359
74CAMK1D0.67200908
75CSF1R0.65034276
76STK380.64154024
77PDPK10.63881530
78PRKD30.63747546
79MAP3K30.63088969
80SIK30.60943845
81CAMK40.60285896
82KIT0.59498792
83PRKAA20.59338342
84MAPKAPK30.59233934
85MAP3K110.56326719
86JAK20.54815068
87FGR0.54500517
88NME10.54496950
89PIK3CA0.52013415
90PRKCH0.51233180
91DAPK20.49451645
92PRKAA10.46913521
93MAPK70.46612678
94RPS6KB10.45859381
95RPS6KA60.45571124
96MELK0.45415662
97MAP4K20.43361242
98MAP2K20.42984799
99MATK0.41735084
100RPS6KC10.41113655

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.11116877
2T cell receptor signaling pathway_Homo sapiens_hsa046602.53157730
3B cell receptor signaling pathway_Homo sapiens_hsa046622.28911794
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.10644338
5Graft-versus-host disease_Homo sapiens_hsa053322.02278462
6Allograft rejection_Homo sapiens_hsa053301.97527456
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.96987825
8Autoimmune thyroid disease_Homo sapiens_hsa053201.96266281
9Type I diabetes mellitus_Homo sapiens_hsa049401.86696536
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.84465283
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77567740
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.76914126
13Acute myeloid leukemia_Homo sapiens_hsa052211.76458831
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76056503
15Complement and coagulation cascades_Homo sapiens_hsa046101.75533367
16ABC transporters_Homo sapiens_hsa020101.73673260
17Measles_Homo sapiens_hsa051621.73350365
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69481531
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.66958940
20Staphylococcus aureus infection_Homo sapiens_hsa051501.65941701
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62940963
22Non-small cell lung cancer_Homo sapiens_hsa052231.61980440
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.57314152
24Herpes simplex infection_Homo sapiens_hsa051681.37865870
25Inositol phosphate metabolism_Homo sapiens_hsa005621.34235698
26Insulin resistance_Homo sapiens_hsa049311.33890288
27Other glycan degradation_Homo sapiens_hsa005111.32919163
28Vitamin digestion and absorption_Homo sapiens_hsa049771.28716592
29Hepatitis C_Homo sapiens_hsa051601.28616518
30Osteoclast differentiation_Homo sapiens_hsa043801.27561173
31Lysine degradation_Homo sapiens_hsa003101.23722354
32mTOR signaling pathway_Homo sapiens_hsa041501.23424501
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23418413
34Prolactin signaling pathway_Homo sapiens_hsa049171.20165244
35Arginine biosynthesis_Homo sapiens_hsa002201.17013302
36Leishmaniasis_Homo sapiens_hsa051401.13168292
37Antigen processing and presentation_Homo sapiens_hsa046121.12637453
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.10138705
39FoxO signaling pathway_Homo sapiens_hsa040681.09690361
40Influenza A_Homo sapiens_hsa051641.09167271
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.06643853
42TNF signaling pathway_Homo sapiens_hsa046681.03459054
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01164983
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00711882
45Glycerolipid metabolism_Homo sapiens_hsa005610.99176849
46Hematopoietic cell lineage_Homo sapiens_hsa046400.98685947
47Choline metabolism in cancer_Homo sapiens_hsa052310.97948755
48Hepatitis B_Homo sapiens_hsa051610.94328494
49VEGF signaling pathway_Homo sapiens_hsa043700.93296968
50Chemokine signaling pathway_Homo sapiens_hsa040620.91967684
51Toxoplasmosis_Homo sapiens_hsa051450.91549196
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91401278
53Endometrial cancer_Homo sapiens_hsa052130.86392143
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84112701
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82060253
56Type II diabetes mellitus_Homo sapiens_hsa049300.80162886
57Butanoate metabolism_Homo sapiens_hsa006500.79912511
58Selenocompound metabolism_Homo sapiens_hsa004500.78996711
59Tuberculosis_Homo sapiens_hsa051520.77168190
60Circadian rhythm_Homo sapiens_hsa047100.74691289
61Viral carcinogenesis_Homo sapiens_hsa052030.73174098
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73134027
63Fat digestion and absorption_Homo sapiens_hsa049750.71956869
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.70813356
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69201303
66Histidine metabolism_Homo sapiens_hsa003400.67337909
67Chronic myeloid leukemia_Homo sapiens_hsa052200.64688457
68Asthma_Homo sapiens_hsa053100.64483276
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63348344
70Pancreatic cancer_Homo sapiens_hsa052120.62502070
71Regulation of autophagy_Homo sapiens_hsa041400.62069372
72Linoleic acid metabolism_Homo sapiens_hsa005910.60251568
73Epstein-Barr virus infection_Homo sapiens_hsa051690.60002352
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58406772
75Insulin signaling pathway_Homo sapiens_hsa049100.57725280
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56262284
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55847920
78Apoptosis_Homo sapiens_hsa042100.55618761
79Prostate cancer_Homo sapiens_hsa052150.54588366
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52916736
81Platelet activation_Homo sapiens_hsa046110.51637641
82Dorso-ventral axis formation_Homo sapiens_hsa043200.51365373
83ErbB signaling pathway_Homo sapiens_hsa040120.50661656
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50244255
85Glucagon signaling pathway_Homo sapiens_hsa049220.50064619
86AMPK signaling pathway_Homo sapiens_hsa041520.49896414
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47062073
88MAPK signaling pathway_Homo sapiens_hsa040100.46882335
89Notch signaling pathway_Homo sapiens_hsa043300.46693059
90Fatty acid biosynthesis_Homo sapiens_hsa000610.44916660
91Viral myocarditis_Homo sapiens_hsa054160.44169723
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44148534
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.42489315
94Retinol metabolism_Homo sapiens_hsa008300.42187893
95Nitrogen metabolism_Homo sapiens_hsa009100.42141214
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.40926247
97Colorectal cancer_Homo sapiens_hsa052100.39733493
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.38796760
99African trypanosomiasis_Homo sapiens_hsa051430.37660199
100mRNA surveillance pathway_Homo sapiens_hsa030150.36343379

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