CLVS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is thought to function in the endosomal pathway between early endosomes and mature lysosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72551589
2vocalization behavior (GO:0071625)5.67510763
3synaptic vesicle exocytosis (GO:0016079)5.46908436
4neuron cell-cell adhesion (GO:0007158)5.34411146
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28575923
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28539069
7cellular potassium ion homeostasis (GO:0030007)5.21787741
8sodium ion export (GO:0071436)5.11494101
9glutamate secretion (GO:0014047)5.11148199
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.02538830
11neurotransmitter-gated ion channel clustering (GO:0072578)4.95199426
12regulation of glutamate receptor signaling pathway (GO:1900449)4.93927899
13protein localization to synapse (GO:0035418)4.87413212
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.85242582
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80934310
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.75773277
17regulation of synaptic vesicle exocytosis (GO:2000300)4.73977098
18glutamate receptor signaling pathway (GO:0007215)4.54538161
19neuron-neuron synaptic transmission (GO:0007270)4.45759320
20presynaptic membrane assembly (GO:0097105)4.43120364
21neuronal action potential propagation (GO:0019227)4.42452741
22synaptic transmission, glutamatergic (GO:0035249)4.40697688
23regulation of synaptic vesicle transport (GO:1902803)4.40456043
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.39980294
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.23438169
26locomotory exploration behavior (GO:0035641)4.20053514
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.18184706
28postsynaptic membrane organization (GO:0001941)4.11926645
29neurotransmitter secretion (GO:0007269)4.10659348
30synaptic vesicle maturation (GO:0016188)4.08012165
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.07557685
32presynaptic membrane organization (GO:0097090)4.06297775
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.98485340
34regulation of neuronal synaptic plasticity (GO:0048168)3.97734847
35auditory behavior (GO:0031223)3.96787626
36long-term synaptic potentiation (GO:0060291)3.93489725
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91899842
38exploration behavior (GO:0035640)3.83305478
39behavioral fear response (GO:0001662)3.82344801
40behavioral defense response (GO:0002209)3.82344801
41neuron recognition (GO:0008038)3.81658920
42neuronal ion channel clustering (GO:0045161)3.78950987
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77548337
44regulation of postsynaptic membrane potential (GO:0060078)3.76209218
45synaptic vesicle endocytosis (GO:0048488)3.76014072
46positive regulation of synapse maturation (GO:0090129)3.74861926
47response to histamine (GO:0034776)3.70379249
48central nervous system myelination (GO:0022010)3.69295876
49axon ensheathment in central nervous system (GO:0032291)3.69295876
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.66403208
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65608574
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.65181931
53L-amino acid import (GO:0043092)3.62819730
54fear response (GO:0042596)3.62428483
55cellular sodium ion homeostasis (GO:0006883)3.62326283
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.61472740
57regulation of synaptic plasticity (GO:0048167)3.61275442
58cell communication by electrical coupling (GO:0010644)3.61249567
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.60479316
60pyrimidine nucleobase catabolic process (GO:0006208)3.60040473
61potassium ion import (GO:0010107)3.58029242
62cell migration in hindbrain (GO:0021535)3.57318918
63positive regulation of membrane potential (GO:0045838)3.56940161
64central nervous system projection neuron axonogenesis (GO:0021952)3.56437954
65potassium ion homeostasis (GO:0055075)3.53027968
66startle response (GO:0001964)3.52479826
67neuromuscular synaptic transmission (GO:0007274)3.49732870
68righting reflex (GO:0060013)3.45320110
69establishment of mitochondrion localization (GO:0051654)3.45066750
70response to auditory stimulus (GO:0010996)3.44545611
71long-term memory (GO:0007616)3.44076539
72neurotransmitter transport (GO:0006836)3.41087828
73transmission of nerve impulse (GO:0019226)3.37930059
74positive regulation of dendritic spine development (GO:0060999)3.37209297
75mechanosensory behavior (GO:0007638)3.35784794
76regulation of glutamate secretion (GO:0014048)3.35128660
77gamma-aminobutyric acid transport (GO:0015812)3.31575947
78axonal fasciculation (GO:0007413)3.31560491
79adult walking behavior (GO:0007628)3.31463054
80proline transport (GO:0015824)3.30785467
81regulation of vesicle fusion (GO:0031338)3.30480934
82regulation of synapse structural plasticity (GO:0051823)3.29922636
83amino acid import (GO:0043090)3.28584748
84cell differentiation in hindbrain (GO:0021533)3.24551977
85dendrite morphogenesis (GO:0048813)3.24207029
86positive regulation of neurotransmitter secretion (GO:0001956)3.23626502
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23376457
88cerebellar Purkinje cell differentiation (GO:0021702)3.22211791
89regulation of neurotransmitter secretion (GO:0046928)3.22040170
90regulation of voltage-gated calcium channel activity (GO:1901385)3.21813273
91striatum development (GO:0021756)3.21708700
92regulation of neurotransmitter levels (GO:0001505)3.18785499
93female mating behavior (GO:0060180)3.18356859
94positive regulation of potassium ion transmembrane transport (GO:1901381)3.18004996
95membrane depolarization (GO:0051899)3.17281771
96positive regulation of neurotransmitter transport (GO:0051590)3.16874922
97behavioral response to cocaine (GO:0048148)3.16648288
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16583239
99regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.16364246
100regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.16364246
101regulation of female receptivity (GO:0045924)3.15743124
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14590711
103negative regulation of dendrite morphogenesis (GO:0050774)3.14314029
104negative regulation of dendrite development (GO:2000171)3.13727102
105cerebellar granule cell differentiation (GO:0021707)3.13445718
106neuromuscular process controlling balance (GO:0050885)3.12683047
107positive regulation of synapse assembly (GO:0051965)3.12043005
108regulation of dendritic spine morphogenesis (GO:0061001)3.11750728
109learning (GO:0007612)3.10426859
110positive regulation of synaptic transmission (GO:0050806)3.10197035
111synaptic transmission (GO:0007268)3.10159362
112long term synaptic depression (GO:0060292)3.09922248
113regulation of synapse maturation (GO:0090128)3.09763552
114cell communication involved in cardiac conduction (GO:0086065)3.06978567
115nucleobase catabolic process (GO:0046113)3.06650528
116regulation of synaptic transmission (GO:0050804)3.06600693
117regulation of neurotransmitter transport (GO:0051588)3.05483732
118transferrin transport (GO:0033572)3.05205373
119dendritic spine morphogenesis (GO:0060997)3.04103116
120serotonin receptor signaling pathway (GO:0007210)3.04086670
121social behavior (GO:0035176)3.03794814
122intraspecies interaction between organisms (GO:0051703)3.03794814
123energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.03399780
124ATP hydrolysis coupled proton transport (GO:0015991)3.03399780
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00634495
126innervation (GO:0060384)3.00050946
127neurotransmitter uptake (GO:0001504)2.99987610
128detection of calcium ion (GO:0005513)2.99962325
129regulation of synaptic transmission, GABAergic (GO:0032228)2.98730353
130layer formation in cerebral cortex (GO:0021819)2.98089050
131synaptic vesicle transport (GO:0048489)2.97882244
132establishment of synaptic vesicle localization (GO:0097480)2.97882244
133dendrite development (GO:0016358)2.93431715
134membrane depolarization during action potential (GO:0086010)2.93141054
135synapse assembly (GO:0007416)2.91439063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.35419518
2GBX2_23144817_ChIP-Seq_PC3_Human4.49110698
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86492802
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83304510
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70867455
6TAF15_26573619_Chip-Seq_HEK293_Human2.60631623
7REST_21632747_ChIP-Seq_MESCs_Mouse2.55969370
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44028176
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36493229
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36493229
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.32896487
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30493724
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26901432
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26386924
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25319714
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25269294
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25204142
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14625774
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11996355
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11363888
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.09291506
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.08067001
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06892493
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05145688
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.04251310
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98837728
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98633314
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97965168
29SMAD4_21799915_ChIP-Seq_A2780_Human1.93341244
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.92603544
31IGF1R_20145208_ChIP-Seq_DFB_Human1.89784506
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86289292
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85796477
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84209609
35P300_19829295_ChIP-Seq_ESCs_Human1.83696304
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.83493864
37FUS_26573619_Chip-Seq_HEK293_Human1.79141194
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78438584
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75599039
40AR_21572438_ChIP-Seq_LNCaP_Human1.75294222
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.73870708
42DROSHA_22980978_ChIP-Seq_HELA_Human1.67518527
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65084817
44RNF2_27304074_Chip-Seq_NSC_Mouse1.64372828
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63118740
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.57418891
47AR_25329375_ChIP-Seq_VCAP_Human1.50707831
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47926143
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.47007105
50VDR_22108803_ChIP-Seq_LS180_Human1.46900502
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.44453580
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44427396
53STAT3_23295773_ChIP-Seq_U87_Human1.40717043
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39578081
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36358772
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.35995694
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33342079
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32079138
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28513453
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26844260
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26821636
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26769540
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25767654
64TCF4_23295773_ChIP-Seq_U87_Human1.25716354
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.25486450
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24234950
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23249679
68JUN_21703547_ChIP-Seq_K562_Human1.21950436
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21277672
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20728150
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20481689
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.18178358
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.16282447
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16128463
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16128463
76SOX9_26525672_Chip-Seq_HEART_Mouse1.15969141
77ZNF274_21170338_ChIP-Seq_K562_Hela1.15220818
78RUNX2_22187159_ChIP-Seq_PCA_Human1.14825610
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14720519
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.12723074
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12540893
82ER_23166858_ChIP-Seq_MCF-7_Human1.12278108
83* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09098507
84AR_19668381_ChIP-Seq_PC3_Human1.08533341
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08077965
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07549705
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07375061
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06903850
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06822861
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.06797275
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05818768
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04819910
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02694678
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02530721
95EWS_26573619_Chip-Seq_HEK293_Human1.02315787
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02303581
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.02255139
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.02254628
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02030091
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01622280
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01481205
102* KDM2B_26808549_Chip-Seq_REH_Human1.01219906
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00331790
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99760323
105P53_22387025_ChIP-Seq_ESCs_Mouse0.98693126
106RING1B_27294783_Chip-Seq_ESCs_Mouse0.98239344
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97763795
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96989075
109BCAT_22108803_ChIP-Seq_LS180_Human0.96563621
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96560482
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96407939
112* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95409956
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94788269
114* FLI1_21867929_ChIP-Seq_TH2_Mouse0.94161153
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.92293767
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.90754096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.83264659
2MP0003880_abnormal_central_pattern5.72785660
3MP0003635_abnormal_synaptic_transmissio3.96214449
4MP0004270_analgesia3.43756265
5MP0009745_abnormal_behavioral_response3.42153672
6MP0002063_abnormal_learning/memory/cond3.29885788
7MP0001968_abnormal_touch/_nociception3.17427823
8MP0002064_seizures3.02050160
9MP0009046_muscle_twitch2.99977079
10MP0002572_abnormal_emotion/affect_behav2.90740835
11MP0002736_abnormal_nociception_after2.85441212
12MP0003787_abnormal_imprinting2.58081565
13MP0002734_abnormal_mechanical_nocicepti2.55136951
14MP0002822_catalepsy2.54874279
15MP0002735_abnormal_chemical_nociception2.52680762
16MP0001501_abnormal_sleep_pattern2.50073796
17MP0002272_abnormal_nervous_system2.48501664
18MP0001486_abnormal_startle_reflex2.39519073
19MP0001440_abnormal_grooming_behavior2.34626895
20MP0006276_abnormal_autonomic_nervous2.27080149
21MP0001529_abnormal_vocalization2.20667930
22MP0005646_abnormal_pituitary_gland2.15129656
23MP0005423_abnormal_somatic_nervous2.10175882
24MP0002067_abnormal_sensory_capabilities2.03986262
25MP0001905_abnormal_dopamine_level1.94248069
26MP0002733_abnormal_thermal_nociception1.86583698
27MP0001970_abnormal_pain_threshold1.85659274
28MP0004924_abnormal_behavior1.82504755
29MP0005386_behavior/neurological_phenoty1.82504755
30MP0003879_abnormal_hair_cell1.81288245
31MP0002184_abnormal_innervation1.77986465
32MP0000778_abnormal_nervous_system1.71979248
33MP0002557_abnormal_social/conspecific_i1.70066877
34MP0001188_hyperpigmentation1.69872401
35MP0001984_abnormal_olfaction1.60114300
36MP0008877_abnormal_DNA_methylation1.54373297
37MP0009780_abnormal_chondrocyte_physiolo1.47878921
38MP0004811_abnormal_neuron_physiology1.44520632
39MP0003122_maternal_imprinting1.44100145
40MP0002837_dystrophic_cardiac_calcinosis1.42931704
41MP0003329_amyloid_beta_deposits1.39689959
42MP0008569_lethality_at_weaning1.38054748
43MP0002066_abnormal_motor_capabilities/c1.34867974
44MP0001502_abnormal_circadian_rhythm1.34797008
45MP0003646_muscle_fatigue1.34549736
46MP0002102_abnormal_ear_morphology1.32974944
47MP0000955_abnormal_spinal_cord1.31293968
48MP0004142_abnormal_muscle_tone1.29974816
49MP0002882_abnormal_neuron_morphology1.29546502
50MP0004147_increased_porphyrin_level1.28076969
51MP0010386_abnormal_urinary_bladder1.25306493
52MP0002909_abnormal_adrenal_gland1.21969768
53MP0005187_abnormal_penis_morphology1.16222586
54MP0005645_abnormal_hypothalamus_physiol1.14765745
55MP0002653_abnormal_ependyma_morphology1.14565997
56MP0002876_abnormal_thyroid_physiology1.12707377
57MP0003123_paternal_imprinting1.11157174
58MP0003690_abnormal_glial_cell1.10812978
59MP0000920_abnormal_myelination1.06034214
60MP0002152_abnormal_brain_morphology1.02626402
61MP0001963_abnormal_hearing_physiology1.02200910
62MP0008872_abnormal_physiological_respon1.01478335
63MP0003121_genomic_imprinting1.00187307
64MP0000751_myopathy0.96628643
65MP0003634_abnormal_glial_cell0.94545643
66MP0004742_abnormal_vestibular_system0.93092275
67MP0000631_abnormal_neuroendocrine_gland0.90672612
68MP0002069_abnormal_eating/drinking_beha0.88429957
69MP0004885_abnormal_endolymph0.87723732
70MP0003633_abnormal_nervous_system0.86034175
71MP0002229_neurodegeneration0.85137068
72MP0003631_nervous_system_phenotype0.84899962
73MP0006292_abnormal_olfactory_placode0.84532423
74MP0002638_abnormal_pupillary_reflex0.83846970
75MP0005394_taste/olfaction_phenotype0.82584614
76MP0005499_abnormal_olfactory_system0.82584614
77MP0001299_abnormal_eye_distance/0.81684322
78MP0004858_abnormal_nervous_system0.81180231
79MP0002752_abnormal_somatic_nervous0.79379360
80MP0004484_altered_response_of0.79358363
81MP0005551_abnormal_eye_electrophysiolog0.79191418
82MP0004085_abnormal_heartbeat0.79049541
83MP0008874_decreased_physiological_sensi0.75216995
84MP0001664_abnormal_digestion0.75196439
85MP0002751_abnormal_autonomic_nervous0.74912466
86MP0004145_abnormal_muscle_electrophysio0.73911933
87MP0001986_abnormal_taste_sensitivity0.72654818
88MP0004215_abnormal_myocardial_fiber0.72399600
89MP0000026_abnormal_inner_ear0.71560369
90MP0001485_abnormal_pinna_reflex0.70979581
91MP0003890_abnormal_embryonic-extraembry0.70598005
92MP0005253_abnormal_eye_physiology0.70556545
93MP0010768_mortality/aging0.68241959
94MP0005535_abnormal_body_temperature0.64952259
95MP0002234_abnormal_pharynx_morphology0.64659821
96MP0003137_abnormal_impulse_conducting0.64306813
97MP0005171_absent_coat_pigmentation0.63511691
98MP0003183_abnormal_peptide_metabolism0.63110496
99MP0000569_abnormal_digit_pigmentation0.62138002
100MP0003632_abnormal_nervous_system0.61311844
101MP0001348_abnormal_lacrimal_gland0.59641791
102MP0002081_perinatal_lethality0.57445342
103MP0004233_abnormal_muscle_weight0.57008190
104MP0003861_abnormal_nervous_system0.55492929
105MP0003283_abnormal_digestive_organ0.55093689
106MP0000566_synostosis0.54178340
107MP0001177_atelectasis0.52926437
108MP0000013_abnormal_adipose_tissue0.51882848
109MP0003956_abnormal_body_size0.51612957
110MP0006072_abnormal_retinal_apoptosis0.51073130
111MP0003119_abnormal_digestive_system0.50814647
112MP0010770_preweaning_lethality0.48391991
113MP0002082_postnatal_lethality0.48391991
114MP0001943_abnormal_respiration0.47168822
115MP0010769_abnormal_survival0.46073140
116MP0000604_amyloidosis0.45715726
117MP0008260_abnormal_autophagy0.45571031
118MP0001765_abnormal_ion_homeostasis0.44845365

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.76005326
2Atonic seizures (HP:0010819)5.87749091
3Myokymia (HP:0002411)5.72009980
4Focal seizures (HP:0007359)5.62333054
5Epileptic encephalopathy (HP:0200134)5.56781913
6Febrile seizures (HP:0002373)5.46657708
7Absence seizures (HP:0002121)4.39398154
8Visual hallucinations (HP:0002367)4.27907147
9Hyperventilation (HP:0002883)4.18291240
10Dialeptic seizures (HP:0011146)4.10144868
11Generalized tonic-clonic seizures (HP:0002069)3.94261229
12Progressive cerebellar ataxia (HP:0002073)3.75839655
13Broad-based gait (HP:0002136)3.73082576
14Amblyopia (HP:0000646)3.34218415
15Gaze-evoked nystagmus (HP:0000640)3.14159016
16Abnormal eating behavior (HP:0100738)3.04507238
17Progressive inability to walk (HP:0002505)2.99230122
18Abnormal hair whorl (HP:0010721)2.93702898
19Excessive salivation (HP:0003781)2.90834171
20Drooling (HP:0002307)2.90834171
21Impaired vibration sensation in the lower limbs (HP:0002166)2.89754003
22Abnormality of the labia minora (HP:0012880)2.88000290
23Fetal akinesia sequence (HP:0001989)2.87993874
24Gait imbalance (HP:0002141)2.83219836
25Polyphagia (HP:0002591)2.83216822
26Papilledema (HP:0001085)2.76767464
27Epileptiform EEG discharges (HP:0011182)2.75709761
28Inability to walk (HP:0002540)2.70226842
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.67120257
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.67120257
31Hemiplegia (HP:0002301)2.65021044
32Dysdiadochokinesis (HP:0002075)2.64876170
33Poor eye contact (HP:0000817)2.60931806
34Dysmetria (HP:0001310)2.59590317
35Neurofibrillary tangles (HP:0002185)2.57428365
36Limb dystonia (HP:0002451)2.53900056
37Congenital primary aphakia (HP:0007707)2.51291764
38EEG with generalized epileptiform discharges (HP:0011198)2.45819886
39Medial flaring of the eyebrow (HP:0010747)2.45245346
40Lower limb muscle weakness (HP:0007340)2.44497819
41Truncal ataxia (HP:0002078)2.41282597
42Urinary bladder sphincter dysfunction (HP:0002839)2.41235795
43Anxiety (HP:0000739)2.40962353
44Absent speech (HP:0001344)2.40770803
45Action tremor (HP:0002345)2.39776759
46Morphological abnormality of the pyramidal tract (HP:0002062)2.38681173
47Abnormal social behavior (HP:0012433)2.38230621
48Impaired social interactions (HP:0000735)2.38230621
49Nephrogenic diabetes insipidus (HP:0009806)2.38135097
50Amyotrophic lateral sclerosis (HP:0007354)2.35452397
51Annular pancreas (HP:0001734)2.34155795
52Cerebral hypomyelination (HP:0006808)2.28839641
53Hypsarrhythmia (HP:0002521)2.27570423
54Protruding tongue (HP:0010808)2.26668733
55Mutism (HP:0002300)2.26173809
56Termporal pattern (HP:0011008)2.25778564
57Insidious onset (HP:0003587)2.25778564
58Obstructive sleep apnea (HP:0002870)2.24626781
59Acute necrotizing encephalopathy (HP:0006965)2.23338696
60Depression (HP:0000716)2.22591065
61Pheochromocytoma (HP:0002666)2.20986241
62Megalencephaly (HP:0001355)2.20490297
63Intention tremor (HP:0002080)2.20214834
64Delusions (HP:0000746)2.19967864
65Akinesia (HP:0002304)2.17281634
66Abnormality of the lower motor neuron (HP:0002366)2.16742568
67Failure to thrive in infancy (HP:0001531)2.15912626
68Poor suck (HP:0002033)2.12749093
69Abnormal mitochondria in muscle tissue (HP:0008316)2.12299841
70Specific learning disability (HP:0001328)2.11691175
71Ankle clonus (HP:0011448)2.09462797
72Progressive macrocephaly (HP:0004481)2.09420675
73Bradykinesia (HP:0002067)2.09099118
74Spastic tetraplegia (HP:0002510)2.08298992
75Torticollis (HP:0000473)2.08205445
76Supranuclear gaze palsy (HP:0000605)2.07612510
77Esotropia (HP:0000565)2.07460897
78Generalized myoclonic seizures (HP:0002123)2.06443373
79Diplopia (HP:0000651)2.05767797
80Abnormality of binocular vision (HP:0011514)2.05767797
81Poor coordination (HP:0002370)2.03464601
82Hemiparesis (HP:0001269)2.02857611
83Blue irides (HP:0000635)2.02734439
84Impaired smooth pursuit (HP:0007772)2.02603040
85Postural instability (HP:0002172)2.02049759
86Genital tract atresia (HP:0001827)2.01923219
87Impaired vibratory sensation (HP:0002495)2.00596545
88Incomplete penetrance (HP:0003829)1.99328404
89Status epilepticus (HP:0002133)1.98585290
90Neuroendocrine neoplasm (HP:0100634)1.98226396
91Focal dystonia (HP:0004373)1.97792864
92Abnormality of salivation (HP:0100755)1.97535771
93Genetic anticipation (HP:0003743)1.96204134
94Narrow nasal bridge (HP:0000446)1.95803975
95Urinary urgency (HP:0000012)1.94970851
96Abnormality of the corticospinal tract (HP:0002492)1.94894819
97Dysmetric saccades (HP:0000641)1.94726863
98Hyperthyroidism (HP:0000836)1.94120408
99Spastic gait (HP:0002064)1.93615428
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92265315
101Clonus (HP:0002169)1.92226740
102Vaginal atresia (HP:0000148)1.92118721
103Spastic tetraparesis (HP:0001285)1.90465758
104Thickened helices (HP:0000391)1.86345791
105Scanning speech (HP:0002168)1.85946855
106Hypothermia (HP:0002045)1.85678175
107Inappropriate behavior (HP:0000719)1.84310317
108Fair hair (HP:0002286)1.81435150
109Peripheral hypomyelination (HP:0007182)1.80220294
110Sleep apnea (HP:0010535)1.79794451
111Tetraplegia (HP:0002445)1.78212524
112Craniofacial dystonia (HP:0012179)1.77998164
113Prolonged QT interval (HP:0001657)1.77976543
114Oligomenorrhea (HP:0000876)1.77511910
115Abnormality of ocular smooth pursuit (HP:0000617)1.76889120
116Cerebral inclusion bodies (HP:0100314)1.76834565
117Hypoplasia of the corpus callosum (HP:0002079)1.75571073
118Exotropia (HP:0000577)1.74789342
119Agitation (HP:0000713)1.74768833
120Stereotypic behavior (HP:0000733)1.74725434
121Hepatoblastoma (HP:0002884)1.73901217
122Generalized hypopigmentation of hair (HP:0011358)1.73886958
123Lissencephaly (HP:0001339)1.73528198
124Apathy (HP:0000741)1.69808381
125Hypoventilation (HP:0002791)1.69208055
126Gait ataxia (HP:0002066)1.68999357
127Acute encephalopathy (HP:0006846)1.64410770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.18895291
2CASK4.04443685
3EPHA43.89695828
4MAP3K93.43678546
5MAP3K43.38100083
6MAP2K73.24006882
7MAP3K123.04636556
8MINK12.25762242
9MARK12.17181155
10KSR22.14566581
11MAP2K42.07242341
12KSR12.06421422
13PLK22.02704868
14CDK191.99673304
15ARAF1.98020672
16DAPK21.91080492
17PRPF4B1.80239149
18NTRK21.76277155
19PAK61.74511622
20DAPK11.70965008
21MAPK131.66416609
22SIK31.65182349
23RIPK41.63587100
24LATS21.60882891
25MAP3K131.57350542
26MUSK1.54938208
27TNIK1.38012640
28GRK51.37049630
29BRAF1.36961458
30BMPR21.34647393
31MAP3K61.31010334
32NME11.23514080
33AKT31.20979857
34RAF11.18394364
35CDK51.18188028
36OXSR11.16291920
37CAMK2A1.15679333
38PRKCG1.11893717
39ERBB41.07332426
40CCNB11.01149089
41PNCK1.00243367
42SGK20.99360088
43PTK2B0.97567352
44SGK2230.96539085
45SGK4940.96539085
46SIK20.93443404
47STK380.93101585
48PRKD30.92939611
49FES0.91374186
50BCR0.91347720
51CAMK40.90403368
52CAMK2B0.89165783
53CDK180.87200272
54PRKCH0.83114203
55FGR0.82053032
56NTRK10.80174120
57PKN10.78403171
58CDK150.76680696
59TAOK10.75906548
60CAMKK10.75052945
61CDK140.71263442
62MOS0.68830177
63STK38L0.67831368
64PDK40.67633951
65PDK30.67633951
66RIPK10.66851912
67DYRK1A0.65714353
68CDK11A0.63880277
69WNK10.62562455
70CAMK1G0.61306929
71PINK10.60004157
72TSSK60.59885556
73CSNK1G20.58573607
74SGK30.57743653
75TYRO30.57101566
76CSNK1A1L0.56216507
77SGK10.55275075
78CDK30.54693848
79MAPK100.54629796
80PRKCZ0.54276577
81PRKCE0.53502135
82CDK80.51677910
83GRK70.51628189
84WNK30.51461714
85DYRK1B0.51373597
86FGFR20.50271192
87CSNK1G30.50087497
88STK110.49024108
89MAP2K10.46252657
90PAK30.46185279
91CSNK1G10.45656185
92RET0.43938998
93MAP3K10.43898293
94FER0.43753813
95CAMK10.43444076
96INSRR0.43218883
97MARK20.43066879
98CAMKK20.41889054
99MAPK120.41639808
100UHMK10.41085238
101CSNK1D0.40636741
102CAMK2D0.39961285
103ERBB30.39936681
104PHKG20.39392540
105PHKG10.39392540
106CAMK2G0.38673802
107ERBB20.38664991
108PRKG10.38395779
109CSNK1E0.38373330
110ROCK20.37618689
111MAP3K20.37551323
112ADRBK10.37455327
113PDK10.36981460
114TRIM280.36271549
115DYRK20.35914519
116FYN0.35162892
117PRKCB0.34480349
118PDPK10.34374872
119FRK0.34120829
120ALK0.34088234
121MAPKAPK50.32153417
122RPS6KA30.30859234
123PLK30.30719942
124PRKACB0.29950287
125ADRBK20.29630238
126LIMK10.28995290
127PRKACA0.28726650
128CSNK1A10.28073624
129MAPK80.27665031
130BMPR1B0.27436271
131GSK3B0.26620142

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.59410632
2Synaptic vesicle cycle_Homo sapiens_hsa047213.78908923
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95986198
4Long-term potentiation_Homo sapiens_hsa047202.78049729
5Olfactory transduction_Homo sapiens_hsa047402.74318544
6Collecting duct acid secretion_Homo sapiens_hsa049662.67258044
7Amphetamine addiction_Homo sapiens_hsa050312.66703454
8Circadian entrainment_Homo sapiens_hsa047132.61653699
9GABAergic synapse_Homo sapiens_hsa047272.60588719
10Glutamatergic synapse_Homo sapiens_hsa047242.55269238
11Morphine addiction_Homo sapiens_hsa050322.53680815
12Dopaminergic synapse_Homo sapiens_hsa047282.28316982
13Salivary secretion_Homo sapiens_hsa049702.01561830
14Taste transduction_Homo sapiens_hsa047421.99566848
15Serotonergic synapse_Homo sapiens_hsa047261.93545335
16Long-term depression_Homo sapiens_hsa047301.90297825
17Insulin secretion_Homo sapiens_hsa049111.85093273
18Cholinergic synapse_Homo sapiens_hsa047251.75554756
19Cocaine addiction_Homo sapiens_hsa050301.66924810
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66190146
21Renin secretion_Homo sapiens_hsa049241.63182545
22Calcium signaling pathway_Homo sapiens_hsa040201.61662561
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60742892
24Gastric acid secretion_Homo sapiens_hsa049711.58865585
25Vibrio cholerae infection_Homo sapiens_hsa051101.55772475
26Oxytocin signaling pathway_Homo sapiens_hsa049211.55393623
27GnRH signaling pathway_Homo sapiens_hsa049121.54023535
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48704161
29Oxidative phosphorylation_Homo sapiens_hsa001901.45015063
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34428692
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28386066
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26248614
33Gap junction_Homo sapiens_hsa045401.25040871
34cAMP signaling pathway_Homo sapiens_hsa040241.22413901
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15770251
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11878844
37Oocyte meiosis_Homo sapiens_hsa041141.10515854
38Alzheimers disease_Homo sapiens_hsa050101.04335556
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03854196
40ErbB signaling pathway_Homo sapiens_hsa040121.02738992
41Estrogen signaling pathway_Homo sapiens_hsa049151.02072880
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01744311
43Phototransduction_Homo sapiens_hsa047441.01493395
44Axon guidance_Homo sapiens_hsa043601.00199465
45Cardiac muscle contraction_Homo sapiens_hsa042601.00129055
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99023024
47Glioma_Homo sapiens_hsa052140.94533068
48Parkinsons disease_Homo sapiens_hsa050120.92212115
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90940658
50Melanogenesis_Homo sapiens_hsa049160.89921641
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.86076902
52Circadian rhythm_Homo sapiens_hsa047100.85668997
53Type II diabetes mellitus_Homo sapiens_hsa049300.81216894
54Huntingtons disease_Homo sapiens_hsa050160.80901362
55Bile secretion_Homo sapiens_hsa049760.79711422
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76639162
57Ovarian steroidogenesis_Homo sapiens_hsa049130.75407171
58Choline metabolism in cancer_Homo sapiens_hsa052310.74590530
59Rheumatoid arthritis_Homo sapiens_hsa053230.69020206
60MAPK signaling pathway_Homo sapiens_hsa040100.68953247
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68515036
62Ras signaling pathway_Homo sapiens_hsa040140.62995811
63Dorso-ventral axis formation_Homo sapiens_hsa043200.62323800
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.60924670
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58192492
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57092542
67Glucagon signaling pathway_Homo sapiens_hsa049220.56663990
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56550040
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55210334
70Pancreatic secretion_Homo sapiens_hsa049720.54988377
71Inositol phosphate metabolism_Homo sapiens_hsa005620.52680065
72Fatty acid biosynthesis_Homo sapiens_hsa000610.50090991
73Thyroid hormone synthesis_Homo sapiens_hsa049180.48264698
74Dilated cardiomyopathy_Homo sapiens_hsa054140.47689554
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46812849
76VEGF signaling pathway_Homo sapiens_hsa043700.46467244
77Type I diabetes mellitus_Homo sapiens_hsa049400.45114339
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44161739
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41761603
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40728487
81Butanoate metabolism_Homo sapiens_hsa006500.40655183
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40407211
83Rap1 signaling pathway_Homo sapiens_hsa040150.39207371
84Prion diseases_Homo sapiens_hsa050200.39196221
85Alcoholism_Homo sapiens_hsa050340.38987264
86Hippo signaling pathway_Homo sapiens_hsa043900.38562728
87Phagosome_Homo sapiens_hsa041450.37817904
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36924541
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35911874
90Wnt signaling pathway_Homo sapiens_hsa043100.35794952
91Colorectal cancer_Homo sapiens_hsa052100.34544018
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.33172179
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.33064516
94Renal cell carcinoma_Homo sapiens_hsa052110.32403124
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32095767
96African trypanosomiasis_Homo sapiens_hsa051430.30260311
97Mineral absorption_Homo sapiens_hsa049780.29386937
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29338215
99Melanoma_Homo sapiens_hsa052180.28672287
100Vitamin B6 metabolism_Homo sapiens_hsa007500.26919105
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26752029
102Ether lipid metabolism_Homo sapiens_hsa005650.26441595
103mTOR signaling pathway_Homo sapiens_hsa041500.26262882
104Endometrial cancer_Homo sapiens_hsa052130.26041489
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25946377
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.24056168
107Hedgehog signaling pathway_Homo sapiens_hsa043400.23796144
108Insulin signaling pathway_Homo sapiens_hsa049100.23732008
109AMPK signaling pathway_Homo sapiens_hsa041520.23375050
110Regulation of autophagy_Homo sapiens_hsa041400.23045758
111Pyruvate metabolism_Homo sapiens_hsa006200.21989779
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21131774
113Tight junction_Homo sapiens_hsa045300.20490183
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20173081
115Endocytosis_Homo sapiens_hsa041440.19908438
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19841606
117Nitrogen metabolism_Homo sapiens_hsa009100.18506477

Most similar genes based on co-expression Upload to Enrichr

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