CLYBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.99347140
2lysine metabolic process (GO:0006553)6.00709596
3lysine catabolic process (GO:0006554)6.00709596
4oxidative demethylation (GO:0070989)5.96261087
5protein prenylation (GO:0018342)5.84765841
6prenylation (GO:0097354)5.84765841
7negative regulation of Ras GTPase activity (GO:0034261)5.70558422
8tricarboxylic acid cycle (GO:0006099)5.55470465
9exogenous drug catabolic process (GO:0042738)5.02396423
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.97093024
11L-phenylalanine metabolic process (GO:0006558)4.97093024
12fatty acid beta-oxidation (GO:0006635)4.95150265
13valine metabolic process (GO:0006573)4.90323451
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.88515323
15L-phenylalanine catabolic process (GO:0006559)4.88515323
16branched-chain amino acid catabolic process (GO:0009083)4.86095659
17NADH metabolic process (GO:0006734)4.80819544
18positive regulation of mitotic sister chromatid separation (GO:1901970)4.78477521
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.78477521
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.78477521
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75084598
222-oxoglutarate metabolic process (GO:0006103)4.74012597
23cysteine metabolic process (GO:0006534)4.69988673
24aspartate family amino acid catabolic process (GO:0009068)4.64223972
25amino-acid betaine metabolic process (GO:0006577)4.63306887
26glyoxylate metabolic process (GO:0046487)4.56204046
27branched-chain amino acid metabolic process (GO:0009081)4.55548200
28epoxygenase P450 pathway (GO:0019373)4.54750797
29imidazole-containing compound metabolic process (GO:0052803)4.52165994
30negative regulation of T cell receptor signaling pathway (GO:0050860)4.48737855
31carnitine metabolic process (GO:0009437)4.48566923
32fatty acid oxidation (GO:0019395)4.47157631
33aromatic amino acid family catabolic process (GO:0009074)4.44011651
34lipid oxidation (GO:0034440)4.43735775
35succinate metabolic process (GO:0006105)4.43112403
36cellular ketone body metabolic process (GO:0046950)4.42666531
37oxaloacetate metabolic process (GO:0006107)4.42283314
38short-chain fatty acid metabolic process (GO:0046459)4.37763789
39fatty acid catabolic process (GO:0009062)4.36574273
40serine family amino acid catabolic process (GO:0009071)4.32785118
41oxidative phosphorylation (GO:0006119)4.30568512
42eosinophil chemotaxis (GO:0048245)4.30179322
43biotin metabolic process (GO:0006768)4.29470596
44regulation of mononuclear cell migration (GO:0071675)4.26764223
45acetyl-CoA metabolic process (GO:0006084)4.17870012
46kynurenine metabolic process (GO:0070189)4.15136086
47alpha-linolenic acid metabolic process (GO:0036109)4.15025797
48tryptophan catabolic process (GO:0006569)4.14809810
49indole-containing compound catabolic process (GO:0042436)4.14809810
50indolalkylamine catabolic process (GO:0046218)4.14809810
51fatty acid transmembrane transport (GO:1902001)4.09559603
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08424288
53carnitine shuttle (GO:0006853)4.06002396
54tricarboxylic acid metabolic process (GO:0072350)4.05039449
55regulation of sister chromatid cohesion (GO:0007063)4.01961994
56monocarboxylic acid catabolic process (GO:0072329)4.01291022
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.01184493
58sulfur amino acid catabolic process (GO:0000098)3.98470795
59autophagic vacuole fusion (GO:0000046)3.94190998
60coenzyme A biosynthetic process (GO:0015937)3.93957777
61alpha-amino acid catabolic process (GO:1901606)3.93817925
62regulation of sequestering of triglyceride (GO:0010889)3.91211497
63regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.90181361
64respiratory electron transport chain (GO:0022904)3.89460524
65tryptophan metabolic process (GO:0006568)3.89025204
66peptidyl-glutamic acid carboxylation (GO:0017187)3.88567643
67protein carboxylation (GO:0018214)3.88567643
68bile acid biosynthetic process (GO:0006699)3.86744243
69eosinophil migration (GO:0072677)3.85027894
70homocysteine metabolic process (GO:0050667)3.84187938
71ketone body metabolic process (GO:1902224)3.79999933
72regulation of triglyceride catabolic process (GO:0010896)3.79941490
73electron transport chain (GO:0022900)3.79375981
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78374383
75cellular amino acid catabolic process (GO:0009063)3.77048950
76regulation of protein activation cascade (GO:2000257)3.74122097
77carboxylic acid catabolic process (GO:0046395)3.74003808
78organic acid catabolic process (GO:0016054)3.74003808
79negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.72993044
80serine family amino acid metabolic process (GO:0009069)3.71299334
81fucose catabolic process (GO:0019317)3.71046566
82L-fucose metabolic process (GO:0042354)3.71046566
83L-fucose catabolic process (GO:0042355)3.71046566
84peptidyl-lysine dimethylation (GO:0018027)3.68921741
85glycine metabolic process (GO:0006544)3.64562597
86energy coupled proton transport, down electrochemical gradient (GO:0015985)3.62842219
87ATP synthesis coupled proton transport (GO:0015986)3.62842219
88S-adenosylmethionine metabolic process (GO:0046500)3.60662088
89branch elongation of an epithelium (GO:0060602)3.58050537
90carnitine transport (GO:0015879)3.55773499
91amino-acid betaine transport (GO:0015838)3.55773499
92NAD metabolic process (GO:0019674)3.55176168
93ethanol oxidation (GO:0006069)3.53462815
94regulation of complement activation (GO:0030449)3.53369464
95regulation of acyl-CoA biosynthetic process (GO:0050812)3.52029441
96uronic acid metabolic process (GO:0006063)3.48364153
97glucuronate metabolic process (GO:0019585)3.48364153
98regulation of fatty acid oxidation (GO:0046320)3.48043623
99coenzyme catabolic process (GO:0009109)3.47972239
100fibrinolysis (GO:0042730)3.47266836
101DNA integration (GO:0015074)3.45774404
102urea metabolic process (GO:0019627)3.45482122
103urea cycle (GO:0000050)3.45482122
104urate metabolic process (GO:0046415)3.43119125
105carnitine transmembrane transport (GO:1902603)3.42517229
106blood coagulation, intrinsic pathway (GO:0007597)3.40139156
107omega-hydroxylase P450 pathway (GO:0097267)3.40023417
108drug metabolic process (GO:0017144)3.38898292
109regulation of fibrinolysis (GO:0051917)3.38101554
110aromatic amino acid family metabolic process (GO:0009072)3.35571331
111positive regulation of fatty acid oxidation (GO:0046321)3.35227947
112serine family amino acid biosynthetic process (GO:0009070)3.33671426
113cellular glucuronidation (GO:0052695)3.32595000
114negative regulation of fatty acid biosynthetic process (GO:0045717)3.31868527
115fat-soluble vitamin biosynthetic process (GO:0042362)3.31785331
116drug transmembrane transport (GO:0006855)3.31079668
117negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.29972570
118protein complex biogenesis (GO:0070271)3.28862764
119nitrogen cycle metabolic process (GO:0071941)3.27858981
120dicarboxylic acid metabolic process (GO:0043648)3.26826597
121regulation of cofactor metabolic process (GO:0051193)3.26816720
122regulation of coenzyme metabolic process (GO:0051196)3.26816720
123quaternary ammonium group transport (GO:0015697)3.26486500
124methionine metabolic process (GO:0006555)3.25782345
125cellular modified amino acid catabolic process (GO:0042219)3.24419115
126phenylpropanoid metabolic process (GO:0009698)3.23189110
127vitamin biosynthetic process (GO:0009110)3.22970433
128methionine biosynthetic process (GO:0009086)3.18394280
129positive regulation of fatty acid beta-oxidation (GO:0032000)3.17793392
130quinone biosynthetic process (GO:1901663)3.17014046
131ubiquinone biosynthetic process (GO:0006744)3.17014046
132bile acid metabolic process (GO:0008206)3.15709795
133thioester metabolic process (GO:0035383)3.15335588
134acyl-CoA metabolic process (GO:0006637)3.15335588
135small molecule catabolic process (GO:0044282)3.15319200
136mitochondrial respiratory chain complex assembly (GO:0033108)3.15264810
137water-soluble vitamin biosynthetic process (GO:0042364)3.14155536
138glutamate metabolic process (GO:0006536)3.12761383
139protein import into peroxisome matrix (GO:0016558)3.10890803
140acylglycerol homeostasis (GO:0055090)3.10136901
141triglyceride homeostasis (GO:0070328)3.10136901
142high-density lipoprotein particle remodeling (GO:0034375)3.09601205
143disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.09372916
144killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.09372916
145fatty acid homeostasis (GO:0055089)3.08160353
146negative regulation of fibrinolysis (GO:0051918)3.07264778
147fructose metabolic process (GO:0006000)3.05575669
148sodium-independent organic anion transport (GO:0043252)3.05494893
149organelle membrane fusion (GO:0090174)3.03707772
150regulation of lipoprotein particle clearance (GO:0010984)3.01212592
151positive regulation of chromosome segregation (GO:0051984)2.99439154
152aldehyde catabolic process (GO:0046185)2.98902937
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98868508
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.98868508
155NADH dehydrogenase complex assembly (GO:0010257)2.98868508
156complement activation, alternative pathway (GO:0006957)2.95329257
157cofactor catabolic process (GO:0051187)2.95010707
158tetrahydrofolate metabolic process (GO:0046653)2.93946602
159drug catabolic process (GO:0042737)2.93743199
160double-strand break repair via nonhomologous end joining (GO:0006303)2.91733217
161non-recombinational repair (GO:0000726)2.91733217
162chaperone-mediated protein transport (GO:0072321)2.90860658
163negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.90482944
164pantothenate metabolic process (GO:0015939)2.89984642
165organ growth (GO:0035265)2.89087749
166regulation of mitochondrial translation (GO:0070129)2.84131417
167vesicle fusion (GO:0006906)2.83243209
168ethanol metabolic process (GO:0006067)2.81368284
169pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78337835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.99786886
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.63520151
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.33903282
4EZH2_22144423_ChIP-Seq_EOC_Human4.93317887
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.86252984
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.03841586
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.96409626
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.85374872
9VDR_22108803_ChIP-Seq_LS180_Human3.83239604
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.78736728
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.17152946
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.08073872
13* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.03677994
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98500120
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90603390
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.57815915
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49735385
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31440304
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29322207
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27448056
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26894599
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25906040
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.23519116
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.19887929
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13324249
26IGF1R_20145208_ChIP-Seq_DFB_Human1.88623001
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85173864
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.83286661
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.80806851
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.74706594
31* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74450803
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70553912
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67247757
34IRF1_19129219_ChIP-ChIP_H3396_Human1.65800947
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64978673
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.63502067
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.60552360
38ZNF263_19887448_ChIP-Seq_K562_Human1.59511473
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59450355
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54620098
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51776189
42CLOCK_20551151_ChIP-Seq_293T_Human1.48930380
43GATA1_22025678_ChIP-Seq_K562_Human1.44403237
44AR_21909140_ChIP-Seq_LNCAP_Human1.43475796
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37480118
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37071783
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35213648
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34896379
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34699824
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34699824
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34699824
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34331803
53DCP1A_22483619_ChIP-Seq_HELA_Human1.31645407
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30851708
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30723065
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26420660
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22703483
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22118822
59AR_21572438_ChIP-Seq_LNCaP_Human1.21171979
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.20502270
61FUS_26573619_Chip-Seq_HEK293_Human1.20127662
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19047691
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18162040
64* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16091741
65* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15268989
66TP53_22573176_ChIP-Seq_HFKS_Human1.15251327
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13253516
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13253516
69ZNF274_21170338_ChIP-Seq_K562_Hela1.12591915
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09482615
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09111112
72BCAT_22108803_ChIP-Seq_LS180_Human1.08068322
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08018091
74FOXP3_21729870_ChIP-Seq_TREG_Human1.07762584
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07513290
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06619971
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06083403
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05232596
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04404621
80RXR_22108803_ChIP-Seq_LS180_Human1.04305251
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02603682
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01408377
83GABP_19822575_ChIP-Seq_HepG2_Human1.00937042
84VDR_23849224_ChIP-Seq_CD4+_Human1.00740082
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99535783
86GATA3_26560356_Chip-Seq_TH1_Human0.99392064
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99295027
88GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98801880
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97503980
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97065564
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96637383
92BP1_19119308_ChIP-ChIP_Hs578T_Human0.94807338
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94413065
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93840688
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92274838
96XRN2_22483619_ChIP-Seq_HELA_Human0.90208534
97* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89979694
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88948504
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88863794
100E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88860358
101ELK1_19687146_ChIP-ChIP_HELA_Human0.87138552
102RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86656184
103OCT4_20526341_ChIP-Seq_ESCs_Human0.86570659
104TTF2_22483619_ChIP-Seq_HELA_Human0.85124773
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84633780
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84467018
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.84195775
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84048795
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82733093
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82509136
111FOXH1_21741376_ChIP-Seq_EPCs_Human0.82149772
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81846558
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.81209021
114KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80929718
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80825384
116P300_19829295_ChIP-Seq_ESCs_Human0.80193259
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80060375
118SOX2_19829295_ChIP-Seq_ESCs_Human0.80042982
119NANOG_19829295_ChIP-Seq_ESCs_Human0.80042982
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79704881
121* NANOG_20526341_ChIP-Seq_ESCs_Human0.79658479
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79009195
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78183495
124EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77213762
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77037705
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76945886
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76939106
128WDR5_24793694_ChIP-Seq_LNCAP_Human0.76504518
129* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76378315
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.76117769
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76117769
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76021012
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73267170
134FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.73259267
135AR_20517297_ChIP-Seq_VCAP_Human0.73136276
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72038330
137ERG_20517297_ChIP-Seq_VCAP_Human0.68604354
138HTT_18923047_ChIP-ChIP_STHdh_Human0.68229499
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.67975943
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.67818926
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67417871
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.65926052
143CTCF_18555785_ChIP-Seq_MESCs_Mouse0.64979579
144CEBPB_22108803_ChIP-Seq_LS180_Human0.64155416
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63934939
146SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.63684336
147* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.63225325
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.63073223
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.63073223
150TAF2_19829295_ChIP-Seq_ESCs_Human0.62409602
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61910930
152* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.60573578
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59792401
154GATA4_25053715_ChIP-Seq_YYC3_Human0.58990145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.18849844
2MP0005360_urolithiasis5.78386157
3MP0002139_abnormal_hepatobiliary_system5.68901032
4MP0003806_abnormal_nucleotide_metabolis4.61825652
5MP0005085_abnormal_gallbladder_physiolo4.40166133
6MP0005365_abnormal_bile_salt4.31185567
7MP0003646_muscle_fatigue3.72452275
8MP0003303_peritoneal_inflammation3.72298924
9MP0002837_dystrophic_cardiac_calcinosis3.42431777
10MP0008875_abnormal_xenobiotic_pharmacok3.26951442
11MP0005332_abnormal_amino_acid3.13999213
12MP0006036_abnormal_mitochondrial_physio2.96814143
13MP0005670_abnormal_white_adipose2.94480275
14MP0004145_abnormal_muscle_electrophysio2.71063005
15MP0010329_abnormal_lipoprotein_level2.63413328
16MP0003186_abnormal_redox_activity2.46509085
17MP0003195_calcinosis2.45696900
18MP0002822_catalepsy2.42051949
19MP0004215_abnormal_myocardial_fiber2.23079746
20MP0009840_abnormal_foam_cell2.19828797
21MP0004130_abnormal_muscle_cell2.18365895
22MP0004084_abnormal_cardiac_muscle2.18341192
23MP0003252_abnormal_bile_duct2.06671336
24MP0001764_abnormal_homeostasis2.01102395
25MP0005319_abnormal_enzyme/_coenzyme1.95894781
26MP0006082_CNS_inflammation1.92163716
27MP0005330_cardiomyopathy1.85949745
28MP0000749_muscle_degeneration1.85362980
29MP0003191_abnormal_cellular_cholesterol1.82929095
30MP0004036_abnormal_muscle_relaxation1.82064549
31MP0008789_abnormal_olfactory_epithelium1.79823704
32MP0004019_abnormal_vitamin_homeostasis1.79646549
33MP0002118_abnormal_lipid_homeostasis1.77332248
34MP0001293_anophthalmia1.76439897
35MP0006292_abnormal_olfactory_placode1.76092794
36MP0009697_abnormal_copulation1.73535852
37MP0000751_myopathy1.73425878
38MP0005666_abnormal_adipose_tissue1.69494417
39MP0005083_abnormal_biliary_tract1.69440131
40MP0003656_abnormal_erythrocyte_physiolo1.68017796
41MP0001666_abnormal_nutrient_absorption1.66946309
42MP0009643_abnormal_urine_homeostasis1.66570057
43MP0005584_abnormal_enzyme/coenzyme_acti1.65613550
44MP0000609_abnormal_liver_physiology1.64387538
45MP0004147_increased_porphyrin_level1.64007958
46MP0006035_abnormal_mitochondrial_morpho1.61692157
47MP0008775_abnormal_heart_ventricle1.49905638
48MP0002876_abnormal_thyroid_physiology1.48269414
49MP0005645_abnormal_hypothalamus_physiol1.41058556
50MP0001919_abnormal_reproductive_system1.40784435
51MP0005266_abnormal_metabolism1.40316994
52MP0002269_muscular_atrophy1.38698692
53MP0001663_abnormal_digestive_system1.38492972
54MP0003879_abnormal_hair_cell1.32991774
55MP0002972_abnormal_cardiac_muscle1.31407476
56MP0005385_cardiovascular_system_phenoty1.31202908
57MP0001544_abnormal_cardiovascular_syste1.31202908
58MP0010030_abnormal_orbit_morphology1.29558006
59MP0005636_abnormal_mineral_homeostasis1.28155569
60MP0002971_abnormal_brown_adipose1.25417283
61MP0004043_abnormal_pH_regulation1.23791775
62MP0006072_abnormal_retinal_apoptosis1.22748270
63MP0003221_abnormal_cardiomyocyte_apopto1.22356734
64MP0005394_taste/olfaction_phenotype1.22057822
65MP0005499_abnormal_olfactory_system1.22057822
66MP0003122_maternal_imprinting1.20880158
67MP0006138_congestive_heart_failure1.20287542
68MP0005389_reproductive_system_phenotype1.19218040
69MP0004087_abnormal_muscle_fiber1.18742802
70MP0008058_abnormal_DNA_repair1.18622274
71MP0000750_abnormal_muscle_regeneration1.18026010
72MP0005620_abnormal_muscle_contractility1.17880614
73MP0002332_abnormal_exercise_endurance1.15346140
74MP0005535_abnormal_body_temperature1.13967640
75MP0005451_abnormal_body_composition1.11493416
76MP0001485_abnormal_pinna_reflex1.09566975
77MP0000383_abnormal_hair_follicle1.09112485
78MP0005646_abnormal_pituitary_gland1.06339451
79MP0005376_homeostasis/metabolism_phenot1.03554525
80MP0003137_abnormal_impulse_conducting1.02414876
81MP0001756_abnormal_urination1.01134953
82MP0002751_abnormal_autonomic_nervous1.00168816
83MP0002138_abnormal_hepatobiliary_system0.98988611
84MP0002132_abnormal_respiratory_system0.98506406
85MP0003718_maternal_effect0.98175239
86MP0002078_abnormal_glucose_homeostasis0.97404125
87MP0001853_heart_inflammation0.96699348
88MP0001664_abnormal_digestion0.94966933
89MP0002938_white_spotting0.94681271
90MP0005551_abnormal_eye_electrophysiolog0.94207711
91MP0000026_abnormal_inner_ear0.92310670
92MP0010630_abnormal_cardiac_muscle0.91982858
93MP0001984_abnormal_olfaction0.91811758
94MP0000598_abnormal_liver_morphology0.90991840
95MP0001963_abnormal_hearing_physiology0.90108442
96MP0005334_abnormal_fat_pad0.89683033
97MP0005647_abnormal_sex_gland0.89323366
98MP0000747_muscle_weakness0.87417722
99MP0000230_abnormal_systemic_arterial0.87404164
100MP0005381_digestive/alimentary_phenotyp0.86662160
101MP0003937_abnormal_limbs/digits/tail_de0.86484403
102MP0002106_abnormal_muscle_physiology0.84620986
103MP0003011_delayed_dark_adaptation0.81007617
104MP0005375_adipose_tissue_phenotype0.79331586
105MP0001529_abnormal_vocalization0.79270261
106MP0000467_abnormal_esophagus_morphology0.76506612
107MP0005166_decreased_susceptibility_to0.76443707
108MP0009642_abnormal_blood_homeostasis0.75962136
109MP0009115_abnormal_fat_cell0.74219158
110MP0002653_abnormal_ependyma_morphology0.72647859
111MP0004484_altered_response_of0.72591355
112MP0003705_abnormal_hypodermis_morpholog0.72330640
113MP0006276_abnormal_autonomic_nervous0.72268252
114MP0009764_decreased_sensitivity_to0.71525632
115MP0009763_increased_sensitivity_to0.70852247
116MP0001286_abnormal_eye_development0.70691078
117MP0002970_abnormal_white_adipose0.70460955
118MP0003868_abnormal_feces_composition0.69510537
119MP0003315_abnormal_perineum_morphology0.69145813
120MP0000343_altered_response_to0.69143945
121MP0002136_abnormal_kidney_physiology0.68670477
122MP0005165_increased_susceptibility_to0.68609440
123MP0002127_abnormal_cardiovascular_syste0.68378461
124MP0002249_abnormal_larynx_morphology0.67462870
125MP0008469_abnormal_protein_level0.67071706
126MP0008872_abnormal_physiological_respon0.66732233
127MP0002638_abnormal_pupillary_reflex0.65867827
128MP0005369_muscle_phenotype0.64660851
129MP0004142_abnormal_muscle_tone0.64201453
130MP0002163_abnormal_gland_morphology0.63645600
131MP0002210_abnormal_sex_determination0.61966264
132MP0000759_abnormal_skeletal_muscle0.61386621
133MP0005253_abnormal_eye_physiology0.61132687
134MP0001346_abnormal_lacrimal_gland0.60858760
135MP0002697_abnormal_eye_size0.60349612
136MP0002752_abnormal_somatic_nervous0.60137076
137MP0000049_abnormal_middle_ear0.59638579
138MP0004185_abnormal_adipocyte_glucose0.59462714
139MP0005397_hematopoietic_system_phenotyp0.59000812
140MP0001545_abnormal_hematopoietic_system0.59000812
141MP0004085_abnormal_heartbeat0.58358703
142MP0000631_abnormal_neuroendocrine_gland0.57222973
143MP0005195_abnormal_posterior_eye0.57112156
144MP0003121_genomic_imprinting0.56754683
145MP0005408_hypopigmentation0.55174582
146MP0005448_abnormal_energy_balance0.54967844
147MP0009379_abnormal_foot_pigmentation0.54735099
148MP0001661_extended_life_span0.54494006
149MP0003953_abnormal_hormone_level0.53780369
150MP0005084_abnormal_gallbladder_morpholo0.52740000
151MP0005395_other_phenotype0.52489287
152MP0005377_hearing/vestibular/ear_phenot0.49257626
153MP0003878_abnormal_ear_physiology0.49257626
154MP0002254_reproductive_system_inflammat0.48252277
155MP0001765_abnormal_ion_homeostasis0.46669676
156MP0005452_abnormal_adipose_tissue0.46073341

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.30330751
2Abnormality of glycine metabolism (HP:0010895)4.58145229
3Abnormality of serine family amino acid metabolism (HP:0010894)4.58145229
4Abnormality of fatty-acid metabolism (HP:0004359)4.56440923
5Hepatic necrosis (HP:0002605)4.50974892
6Hyperammonemia (HP:0001987)4.50098881
7Hyperglycinemia (HP:0002154)4.40232563
8Hypoglycemic coma (HP:0001325)4.35364428
9Dicarboxylic aciduria (HP:0003215)4.31092019
10Abnormality of dicarboxylic acid metabolism (HP:0010995)4.31092019
11Ketosis (HP:0001946)4.15541362
12Cerebral edema (HP:0002181)4.11889085
13Acute encephalopathy (HP:0006846)4.07039204
14Abnormality of aromatic amino acid family metabolism (HP:0004338)4.00810366
15Ketoacidosis (HP:0001993)3.94774809
16Hepatocellular necrosis (HP:0001404)3.86114396
17Myoglobinuria (HP:0002913)3.85019972
18Abnormal mitochondria in muscle tissue (HP:0008316)3.78270862
19Acute necrotizing encephalopathy (HP:0006965)3.72324282
20Lethargy (HP:0001254)3.67080610
21Intrahepatic cholestasis (HP:0001406)3.63294509
22Generalized aminoaciduria (HP:0002909)3.61327618
23Increased muscle lipid content (HP:0009058)3.47853973
24Rhabdomyolysis (HP:0003201)3.47527955
25Increased CSF lactate (HP:0002490)3.46796933
26Mitochondrial inheritance (HP:0001427)3.41768376
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40881617
28Nausea (HP:0002018)3.38943842
29Xanthomatosis (HP:0000991)3.37903157
30Abnormality of serum amino acid levels (HP:0003112)3.37791248
31Lactic acidosis (HP:0003128)3.35378256
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29875647
33Muscle fiber inclusion bodies (HP:0100299)3.29092635
34Progressive muscle weakness (HP:0003323)3.27302723
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.26719712
36Duplicated collecting system (HP:0000081)3.26022875
37Metabolic acidosis (HP:0001942)3.18886932
38Proximal tubulopathy (HP:0000114)3.18233207
39Nemaline bodies (HP:0003798)3.13896766
40Abnormality of the renal collecting system (HP:0004742)3.13755509
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13095473
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.13049465
43Abnormality of glycolysis (HP:0004366)3.09300291
44Increased serum pyruvate (HP:0003542)3.09300291
45Progressive macrocephaly (HP:0004481)3.04758875
46Hypobetalipoproteinemia (HP:0003563)3.02894210
47Gout (HP:0001997)3.00286018
48Steatorrhea (HP:0002570)3.00178142
49Hyperlipoproteinemia (HP:0010980)2.99656025
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99125866
51Renal Fanconi syndrome (HP:0001994)2.95836220
52Deep venous thrombosis (HP:0002625)2.95711404
53Hypoalphalipoproteinemia (HP:0003233)2.91527210
54Increased intramyocellular lipid droplets (HP:0012240)2.91171083
55Vomiting (HP:0002013)2.86239131
56Palpitations (HP:0001962)2.84696882
57Hypolipoproteinemia (HP:0010981)2.84223231
58Increased serum lactate (HP:0002151)2.81640330
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78177345
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78177345
61Abnormality of alanine metabolism (HP:0010916)2.75378676
62Hyperalaninemia (HP:0003348)2.75378676
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75378676
64Brushfield spots (HP:0001088)2.74038421
65Abnormality of urine glucose concentration (HP:0011016)2.72966870
66Glycosuria (HP:0003076)2.72966870
67Long foot (HP:0001833)2.71545545
68Methylmalonic aciduria (HP:0012120)2.71137925
69Abnormality of methionine metabolism (HP:0010901)2.70739602
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.70135356
71Prolonged partial thromboplastin time (HP:0003645)2.65781566
72Exercise-induced muscle cramps (HP:0003710)2.63204555
73Abnormality of purine metabolism (HP:0004352)2.59945739
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.59713091
75Hyperphosphaturia (HP:0003109)2.59360953
76Lipid accumulation in hepatocytes (HP:0006561)2.58457682
77Respiratory failure (HP:0002878)2.57950152
78Ragged-red muscle fibers (HP:0003200)2.57457562
79Delayed CNS myelination (HP:0002188)2.55851768
80Exercise intolerance (HP:0003546)2.54058377
81Increased purine levels (HP:0004368)2.53412445
82Hyperuricemia (HP:0002149)2.53412445
83Hypoplastic pelvis (HP:0008839)2.48819245
84Abnormality of nucleobase metabolism (HP:0010932)2.46128202
85Sudden death (HP:0001699)2.45216276
86Exercise-induced myalgia (HP:0003738)2.45181098
87Abnormality of renal resorption (HP:0011038)2.44495406
88CNS demyelination (HP:0007305)2.43738541
89Hyperbilirubinemia (HP:0002904)2.42208441
90Renal cortical cysts (HP:0000803)2.36193675
91Abnormal urine phosphate concentration (HP:0012599)2.35076157
92Neoplasm of head and neck (HP:0012288)2.34242443
93Esophageal neoplasm (HP:0100751)2.34242443
94Complement deficiency (HP:0004431)2.31934790
95Ventricular tachycardia (HP:0004756)2.31563063
96Large for gestational age (HP:0001520)2.31339296
97Conjunctival hamartoma (HP:0100780)2.27751482
98Joint hemorrhage (HP:0005261)2.26420707
99Abnormal respiratory motile cilium physiology (HP:0012261)2.24453071
100Sensorimotor neuropathy (HP:0007141)2.21531142
101True hermaphroditism (HP:0010459)2.19047543
102Abnormality of pyrimidine metabolism (HP:0004353)2.18493127
103Dry hair (HP:0011359)2.16677711
104Fat malabsorption (HP:0002630)2.15942443
105Lipoatrophy (HP:0100578)2.14269362
106Systemic lupus erythematosus (HP:0002725)2.13247507
107Acute lymphatic leukemia (HP:0006721)2.12021223
108Cholelithiasis (HP:0001081)2.11778373
109Epidermoid cyst (HP:0200040)2.09305446
110Severe muscular hypotonia (HP:0006829)2.09074035
111Pancreatic fibrosis (HP:0100732)2.05668259
112Abnormality of proline metabolism (HP:0010907)2.05214501
113Hydroxyprolinuria (HP:0003080)2.05214501
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03839805
115Muscle hypertrophy of the lower extremities (HP:0008968)2.03489853
116Dilated cardiomyopathy (HP:0001644)2.02940645
117Abnormality of complement system (HP:0005339)2.01193450
118Osteomalacia (HP:0002749)2.00792045
119Abnormality of cells of the erythroid lineage (HP:0012130)1.99042280
120Increased hepatocellular lipid droplets (HP:0006565)1.97259873
121Abnormal gallbladder morphology (HP:0012437)1.96918796
122Calf muscle hypertrophy (HP:0008981)1.96697611
123Methylmalonic acidemia (HP:0002912)1.95149088
124Reticulocytopenia (HP:0001896)1.94100233
125Abnormal number of erythroid precursors (HP:0012131)1.93482461
126Macrocytic anemia (HP:0001972)1.89462078
127Exertional dyspnea (HP:0002875)1.87555311
128Atrioventricular block (HP:0001678)1.86417704
129Limb hypertonia (HP:0002509)1.86389204
130Adactyly (HP:0009776)1.85076879
131Late onset (HP:0003584)1.84237933
132Hypertriglyceridemia (HP:0002155)1.84228762
133Multiple enchondromatosis (HP:0005701)1.84051120
134Right ventricular cardiomyopathy (HP:0011663)1.83931863
135Oligomenorrhea (HP:0000876)1.83752114
136Decreased muscle mass (HP:0003199)1.81011536
137Abnormal ciliary motility (HP:0012262)1.80379918
138Generalized muscle weakness (HP:0003324)1.77316306
139Autoamputation (HP:0001218)1.75515851
140Bile duct proliferation (HP:0001408)1.73828264
141Abnormal biliary tract physiology (HP:0012439)1.73828264
142Conjugated hyperbilirubinemia (HP:0002908)1.72419841
143Chronic bronchitis (HP:0004469)1.71273497
144Congenital stationary night blindness (HP:0007642)1.68933821
145Cerebral palsy (HP:0100021)1.67935680
146Nephronophthisis (HP:0000090)1.66254283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK29.70495509
2BCKDK6.93625618
3MKNK16.12008357
4PDK34.04766950
5PDK44.04766950
6TAOK13.67959671
7NEK13.24393536
8MUSK3.14566107
9STK38L2.73621827
10NME22.65473058
11OBSCN2.65016167
12PINK12.43408627
13PDK22.41369412
14EIF2AK12.36952647
15MYLK2.31399863
16LMTK22.23415533
17PKN21.85537115
18JAK31.81133656
19NME11.75268100
20TTN1.70627988
21STK241.70031015
22FLT31.69340758
23PHKG21.60443819
24PHKG11.60443819
25NEK91.57132762
26MAPKAPK31.47830782
27TRIB31.47757785
28STK161.34966694
29DYRK1A1.32866950
30SIK11.28919523
31CDK191.27084874
32VRK21.24063955
33PIK3CA1.22788234
34PASK1.20156897
35MAP2K31.20139744
36WNK41.19526118
37TIE11.17881590
38CDC71.08946145
39MAP4K21.06466656
40MAP2K41.05863758
41ERBB41.05023052
42PRKAA21.03445079
43FGFR41.03195639
44WEE11.02021945
45IRAK31.00546012
46ABL20.98802589
47BRSK20.97897674
48MAP3K30.96305009
49PIM20.94599789
50MAPK120.91821464
51MAPK110.91302744
52ERN10.89429386
53INSRR0.88695615
54EPHA40.88193419
55NUAK10.88178547
56MST1R0.86146067
57EIF2AK30.85865693
58CASK0.84786944
59WNK30.83791937
60TTK0.83338186
61MAP3K110.81632352
62ZAK0.80406840
63GRK70.80232428
64KDR0.80099369
65ARAF0.79912324
66TNIK0.79427402
67GRK10.79224075
68TLK10.78521116
69TAOK20.77185042
70MAP2K60.76917029
71PRKAA10.73792702
72TYK20.73697503
73BRAF0.73321175
74PIK3CG0.69502209
75CDK40.59561588
76CAMKK10.56382342
77MAP3K50.55876866
78CHEK20.55599691
79LATS10.54368921
80PRKACG0.54023619
81RIPK10.53686628
82TGFBR20.52888510
83STK390.49702997
84PRKCQ0.48471767
85PRKG20.48314188
86CSNK1A10.46343729
87MAP3K40.46170393
88SGK20.44731580
89KIT0.44160384
90TRPM70.43907469
91LATS20.43222645
92JAK20.42261780
93BUB10.40251430
94CAMK2G0.39618574
95CAMKK20.38632973
96LRRK20.38049073
97PLK40.37935744
98PRKACA0.37674332
99EPHB20.37660033
100TESK20.36716175
101CSNK1G30.34937776
102AURKA0.34872071
103MAPK40.34506390
104PLK10.33566467
105MAP3K60.33540802
106CSNK2A10.33443671
107VRK10.33276125
108SGK30.33121741
109DYRK1B0.31999839
110ILK0.31728210
111MAP3K80.31709007
112DYRK30.31623971
113MAP2K10.30972153
114EIF2AK20.30374950
115AURKB0.29624619
116TNK20.29205552
117MAP3K10.29111687
118MAP3K70.28438989
119SRPK10.28353419
120CSNK1G10.28229982
121AKT20.27996747
122OXSR10.27936616
123ADRBK20.27365963
124AKT30.27197882
125ATR0.26945270
126CCNB10.26449927
127CSNK1E0.26311221
128GRK50.25462131
129PLK30.25371334
130BRSK10.25295427
131PRKACB0.25097697
132TSSK60.24135133
133CDK80.23928840
134CSNK2A20.23173004
135CAMK1D0.21292694
136PRKCG0.21120521
137TAOK30.20975584
138MAPK150.20384777
139MAP2K70.20025157
140CSNK1G20.19982091
141STK40.19508980
142CAMK40.19393792
143RPS6KA50.19060317
144FGFR20.18336944
145PRKCA0.17254658
146MST40.17164729
147CSNK1A1L0.16412915
148ACVR1B0.15542830
149PRKG10.15509023
150NEK20.15159961
151DYRK20.14621118
152TEC0.13634125
153STK110.13027606
154ERBB30.12641575
155RPS6KA60.12047719

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.73441748
2Propanoate metabolism_Homo sapiens_hsa006403.40313939
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.32606601
4Fatty acid degradation_Homo sapiens_hsa000713.09110172
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08677125
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.06473733
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73906438
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.71873316
9Fatty acid metabolism_Homo sapiens_hsa012122.40747886
10Carbon metabolism_Homo sapiens_hsa012002.33092779
11Pyruvate metabolism_Homo sapiens_hsa006202.28707973
12Butanoate metabolism_Homo sapiens_hsa006502.23212372
13Peroxisome_Homo sapiens_hsa041462.11879175
14Tryptophan metabolism_Homo sapiens_hsa003802.09695123
15Arginine biosynthesis_Homo sapiens_hsa002202.09296945
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06664834
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00551101
18Oxidative phosphorylation_Homo sapiens_hsa001901.99328145
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97869133
20PPAR signaling pathway_Homo sapiens_hsa033201.89622855
21Parkinsons disease_Homo sapiens_hsa050121.86170608
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82466801
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82410524
24beta-Alanine metabolism_Homo sapiens_hsa004101.81192901
25Biosynthesis of amino acids_Homo sapiens_hsa012301.75792902
26Nitrogen metabolism_Homo sapiens_hsa009101.71543098
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68754295
28Fatty acid elongation_Homo sapiens_hsa000621.57299728
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48127699
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.47823925
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46661391
32Phenylalanine metabolism_Homo sapiens_hsa003601.35243509
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34302897
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33063290
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32432773
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31549074
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31359455
38Folate biosynthesis_Homo sapiens_hsa007901.29358942
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.26898132
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.23779409
41Complement and coagulation cascades_Homo sapiens_hsa046101.22223202
42Huntingtons disease_Homo sapiens_hsa050161.20006914
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19411072
44Chemical carcinogenesis_Homo sapiens_hsa052041.16725166
45Starch and sucrose metabolism_Homo sapiens_hsa005001.15818992
46Alzheimers disease_Homo sapiens_hsa050101.14807976
47Tyrosine metabolism_Homo sapiens_hsa003501.12615844
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09925980
49Pentose phosphate pathway_Homo sapiens_hsa000301.04417468
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02857554
51Arginine and proline metabolism_Homo sapiens_hsa003301.02797753
52Selenocompound metabolism_Homo sapiens_hsa004500.99688711
53Sulfur metabolism_Homo sapiens_hsa009200.98253491
54Cardiac muscle contraction_Homo sapiens_hsa042600.97435074
55Glutathione metabolism_Homo sapiens_hsa004800.97415168
56Histidine metabolism_Homo sapiens_hsa003400.97361195
57Retinol metabolism_Homo sapiens_hsa008300.97146574
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96638542
59Caffeine metabolism_Homo sapiens_hsa002320.96417787
60Vitamin B6 metabolism_Homo sapiens_hsa007500.94379445
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91963915
62Fructose and mannose metabolism_Homo sapiens_hsa000510.88036931
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.87947391
64Fat digestion and absorption_Homo sapiens_hsa049750.86861770
65Sulfur relay system_Homo sapiens_hsa041220.85791758
66Glycerolipid metabolism_Homo sapiens_hsa005610.85032018
67Proteasome_Homo sapiens_hsa030500.83726368
68Fatty acid biosynthesis_Homo sapiens_hsa000610.83552261
69Metabolic pathways_Homo sapiens_hsa011000.81305816
70Bile secretion_Homo sapiens_hsa049760.79873125
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79281749
72One carbon pool by folate_Homo sapiens_hsa006700.76828928
73Vitamin digestion and absorption_Homo sapiens_hsa049770.68194063
74Galactose metabolism_Homo sapiens_hsa000520.67817362
75Ribosome_Homo sapiens_hsa030100.60507328
76Phototransduction_Homo sapiens_hsa047440.55910689
77Lysine degradation_Homo sapiens_hsa003100.55902075
78Pyrimidine metabolism_Homo sapiens_hsa002400.53930127
79ABC transporters_Homo sapiens_hsa020100.52338486
80Staphylococcus aureus infection_Homo sapiens_hsa051500.50347572
81Base excision repair_Homo sapiens_hsa034100.49489692
82Homologous recombination_Homo sapiens_hsa034400.45349082
83RNA degradation_Homo sapiens_hsa030180.39863506
84RNA polymerase_Homo sapiens_hsa030200.36878747
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36528930
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33873731
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.33836853
88Protein export_Homo sapiens_hsa030600.33600712
89Systemic lupus erythematosus_Homo sapiens_hsa053220.33053583
90Taste transduction_Homo sapiens_hsa047420.31639213
91Glucagon signaling pathway_Homo sapiens_hsa049220.30495624
92Spliceosome_Homo sapiens_hsa030400.28489572
93RNA transport_Homo sapiens_hsa030130.27977798
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26584568
95Fanconi anemia pathway_Homo sapiens_hsa034600.24389865
96Insulin resistance_Homo sapiens_hsa049310.22182233
97Purine metabolism_Homo sapiens_hsa002300.21523370
98DNA replication_Homo sapiens_hsa030300.19518223
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18766777
100Arachidonic acid metabolism_Homo sapiens_hsa005900.18105808
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.16229898
102Basal cell carcinoma_Homo sapiens_hsa052170.15868699
103AMPK signaling pathway_Homo sapiens_hsa041520.15470894
104Renin-angiotensin system_Homo sapiens_hsa046140.14331735
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.11849276
106Collecting duct acid secretion_Homo sapiens_hsa049660.11588975
107Ether lipid metabolism_Homo sapiens_hsa005650.11332331
108Linoleic acid metabolism_Homo sapiens_hsa005910.11148100
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.11019244
110Regulation of autophagy_Homo sapiens_hsa041400.08854281
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08435894
112Steroid biosynthesis_Homo sapiens_hsa001000.07117756
113Insulin signaling pathway_Homo sapiens_hsa049100.06926068
114Mismatch repair_Homo sapiens_hsa034300.06120536
115Nucleotide excision repair_Homo sapiens_hsa034200.00892241
116Circadian rhythm_Homo sapiens_hsa04710-0.0381837
117Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0031556

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