CMAHP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.91550266
2cilium or flagellum-dependent cell motility (GO:0001539)5.78732269
3positive regulation of gamma-delta T cell activation (GO:0046645)5.24464214
4positive regulation of B cell differentiation (GO:0045579)4.49870849
5neutrophil activation involved in immune response (GO:0002283)4.30728995
6regulation of gamma-delta T cell differentiation (GO:0045586)4.25166711
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12184629
8regulation of gamma-delta T cell activation (GO:0046643)4.03978607
9cilium movement (GO:0003341)4.01846733
10positive regulation of granulocyte differentiation (GO:0030854)4.01811690
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98512389
12positive thymic T cell selection (GO:0045059)3.97873186
13positive regulation of tolerance induction (GO:0002645)3.90677012
14negative T cell selection (GO:0043383)3.89906465
15regulation of B cell receptor signaling pathway (GO:0050855)3.86697201
16tolerance induction (GO:0002507)3.86252194
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85568812
18negative thymic T cell selection (GO:0045060)3.76147871
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68627396
20positive T cell selection (GO:0043368)3.68546675
21antigen processing and presentation of endogenous antigen (GO:0019883)3.68073463
22regulation of B cell differentiation (GO:0045577)3.67985186
23regulation of regulatory T cell differentiation (GO:0045589)3.64465999
24regulation of tolerance induction (GO:0002643)3.63543415
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62568466
26negative regulation of T cell apoptotic process (GO:0070233)3.60561244
27motile cilium assembly (GO:0044458)3.55982125
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53754141
29immunoglobulin mediated immune response (GO:0016064)3.53352897
30regulation of germinal center formation (GO:0002634)3.45028346
31negative regulation of thymocyte apoptotic process (GO:0070244)3.43976359
32neutrophil activation (GO:0042119)3.33675462
33B cell receptor signaling pathway (GO:0050853)3.32702246
34granulocyte activation (GO:0036230)3.29482675
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28009786
36negative regulation of cell killing (GO:0031342)3.27866443
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27866443
38T cell selection (GO:0045058)3.27262102
39epithelial cilium movement (GO:0003351)3.24957576
40T cell migration (GO:0072678)3.21961396
41thymic T cell selection (GO:0045061)3.20175703
42hepatocyte apoptotic process (GO:0097284)3.16437209
43regulation of alpha-beta T cell proliferation (GO:0046640)3.16143459
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10029743
45response to interleukin-15 (GO:0070672)3.09303470
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08866898
47cellular response to interleukin-15 (GO:0071350)3.06273756
48B cell mediated immunity (GO:0019724)3.05905084
49positive regulation of macrophage differentiation (GO:0045651)3.04041915
50negative regulation of adaptive immune response (GO:0002820)3.03114903
51regulation of interleukin-2 biosynthetic process (GO:0045076)2.99607535
52negative regulation of erythrocyte differentiation (GO:0045647)2.92899246
53positive regulation of chemokine secretion (GO:0090197)2.90369508
54megakaryocyte development (GO:0035855)2.88548238
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87878186
56interferon-gamma-mediated signaling pathway (GO:0060333)2.86291819
57purine nucleotide salvage (GO:0032261)2.85378298
58regulation of vitamin D biosynthetic process (GO:0060556)2.84644558
59negative regulation of T-helper cell differentiation (GO:0045623)2.83158511
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83158511
61T cell costimulation (GO:0031295)2.82013173
62regulation of T-helper 1 cell differentiation (GO:0045625)2.80764487
63thrombin receptor signaling pathway (GO:0070493)2.79462208
64activated T cell proliferation (GO:0050798)2.79409341
65lymphocyte costimulation (GO:0031294)2.77808710
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.76246210
67regulation of interleukin-4 production (GO:0032673)2.75153337
68myeloid cell activation involved in immune response (GO:0002275)2.75069251
69regulation of antigen processing and presentation (GO:0002577)2.74071463
70regulation of platelet aggregation (GO:0090330)2.73210582
71detection of bacterium (GO:0016045)2.72745918
72regulation of T cell tolerance induction (GO:0002664)2.71703555
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71576483
74antigen receptor-mediated signaling pathway (GO:0050851)2.70066783
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67518802
76detection of other organism (GO:0098543)2.67355094
77mature B cell differentiation involved in immune response (GO:0002313)2.67168003
78germinal center formation (GO:0002467)2.67150874
79cellular extravasation (GO:0045123)2.66849522
80Peyers patch development (GO:0048541)2.65150110
81mucosal-associated lymphoid tissue development (GO:0048537)2.65150110
82leukocyte degranulation (GO:0043299)2.64517084
83regulation of granulocyte differentiation (GO:0030852)2.63861634
84negative regulation of interleukin-12 production (GO:0032695)2.62947167
85negative regulation of B cell mediated immunity (GO:0002713)2.61992074
86negative regulation of immunoglobulin mediated immune response (GO:0002890)2.61992074
87axoneme assembly (GO:0035082)2.60559469
88negative regulation of lymphocyte apoptotic process (GO:0070229)2.60421947
89response to type I interferon (GO:0034340)2.59180902
90positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.59040257
91cytidine metabolic process (GO:0046087)2.58394244
92cytidine catabolic process (GO:0006216)2.58394244
93cytidine deamination (GO:0009972)2.58394244
94cellular response to type I interferon (GO:0071357)2.58260211
95type I interferon signaling pathway (GO:0060337)2.58260211
96regulation of chronic inflammatory response (GO:0002676)2.57244468
97regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57147499
98regulation of interleukin-5 production (GO:0032674)2.56475789
99regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.53710978
100positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52035487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.82057422
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.46740735
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.13932856
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.76724381
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.96932608
6RUNX_20019798_ChIP-Seq_JUKART_Human3.11081794
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.09342869
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96897814
9SCL_19346495_ChIP-Seq_HPC-7_Human2.93485070
10MYB_26560356_Chip-Seq_TH2_Human2.81517434
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77483178
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75110119
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.52375513
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44874690
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26654368
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21430317
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19985357
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18972740
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16241142
20MYB_26560356_Chip-Seq_TH1_Human2.15166499
21GATA3_27048872_Chip-Seq_THYMUS_Human2.07818840
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06778195
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.04915751
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98496811
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95527178
26* SPI1_23547873_ChIP-Seq_NB4_Human1.93138396
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90753836
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.88462465
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.87300192
30SPI1_23127762_ChIP-Seq_K562_Human1.83631147
31MAF_26560356_Chip-Seq_TH1_Human1.78348035
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76938656
33VDR_24763502_ChIP-Seq_THP-1_Human1.76035429
34UTX_26944678_Chip-Seq_JUKART_Human1.75728051
35GATA1_19941826_ChIP-Seq_K562_Human1.73671959
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.70394354
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68698868
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68593378
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68087900
40GATA3_26560356_Chip-Seq_TH2_Human1.67380974
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65225182
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.62896773
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58398601
44VDR_24787735_ChIP-Seq_THP-1_Human1.54246099
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53491308
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.50110367
47GATA2_19941826_ChIP-Seq_K562_Human1.48364152
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37139188
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35844273
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33784257
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32429906
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26115099
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25478390
54MAF_26560356_Chip-Seq_TH2_Human1.24541364
55STAT1_20625510_ChIP-Seq_HELA_Human1.22701150
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17758003
57VDR_21846776_ChIP-Seq_THP-1_Human1.15380490
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12957569
59SMRT_27268052_Chip-Seq_Bcells_Human1.09641206
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08867889
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08822563
62MYC_22102868_ChIP-Seq_BL_Human1.08703360
63GATA1_22025678_ChIP-Seq_K562_Human1.02428502
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00495914
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97384182
66PU_27001747_Chip-Seq_BMDM_Mouse0.96212438
67TCF7_22412390_ChIP-Seq_EML_Mouse0.95392072
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95282068
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.93517300
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92754181
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92384141
72VDR_22108803_ChIP-Seq_LS180_Human0.92119834
73EGR1_19374776_ChIP-ChIP_THP-1_Human0.92043237
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91067796
75GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90252046
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.88313436
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86660015
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85972425
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84197310
80CEBPB_22108803_ChIP-Seq_LS180_Human0.83465398
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82776807
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82186462
83GATA3_26560356_Chip-Seq_TH1_Human0.80040074
84P300_27268052_Chip-Seq_Bcells_Human0.78235795
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78182132
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77917781
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77646245
88DROSHA_22980978_ChIP-Seq_HELA_Human0.76468801
89TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75743104
90NCOR1_26117541_ChIP-Seq_K562_Human0.72779778
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70874715
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69567613
93SOX2_20726797_ChIP-Seq_SW620_Human0.68833504
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68685405
95SPI1_20517297_ChIP-Seq_HL60_Human0.68633655
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68214924
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67546324
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.66440050
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66180975
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65613534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.00443584
2MP0001835_abnormal_antigen_presentation3.84998992
3MP0005464_abnormal_platelet_physiology3.54291943
4MP0005671_abnormal_response_to3.49122243
5MP0003436_decreased_susceptibility_to2.97088698
6MP0003763_abnormal_thymus_physiology2.84971472
7MP0001800_abnormal_humoral_immune2.81866886
8MP0005000_abnormal_immune_tolerance2.78661724
9MP0003303_peritoneal_inflammation2.67908968
10MP0002148_abnormal_hypersensitivity_rea2.65526984
11MP0001790_abnormal_immune_system2.61233227
12MP0005387_immune_system_phenotype2.61233227
13MP0009785_altered_susceptibility_to2.53287489
14MP0002723_abnormal_immune_serum2.39607696
15MP0002132_abnormal_respiratory_system2.37355421
16MP0005025_abnormal_response_to2.36928162
17MP0010155_abnormal_intestine_physiology2.31839298
18MP0002452_abnormal_antigen_presenting2.29017325
19MP0002166_altered_tumor_susceptibility2.23656140
20MP0002420_abnormal_adaptive_immunity2.23648395
21MP0001819_abnormal_immune_cell2.20013647
22MP0002396_abnormal_hematopoietic_system2.19499654
23MP0002419_abnormal_innate_immunity2.18156374
24MP0000685_abnormal_immune_system2.10894962
25MP0002398_abnormal_bone_marrow2.07347798
26MP0002405_respiratory_system_inflammati1.98846669
27MP0009333_abnormal_splenocyte_physiolog1.95768019
28MP0004947_skin_inflammation1.94672112
29MP0000716_abnormal_immune_system1.83284035
30MP0000465_gastrointestinal_hemorrhage1.74845247
31MP0003300_gastrointestinal_ulcer1.74742813
32MP0006082_CNS_inflammation1.74346637
33MP0001845_abnormal_inflammatory_respons1.73003515
34MP0003866_abnormal_defecation1.71727181
35MP0002006_tumorigenesis1.69922924
36MP0001533_abnormal_skeleton_physiology1.69762380
37MP0002722_abnormal_immune_system1.63147316
38MP0000689_abnormal_spleen_morphology1.61549719
39MP0008004_abnormal_stomach_pH1.60312570
40MP0000703_abnormal_thymus_morphology1.57709378
41MP0005397_hematopoietic_system_phenotyp1.55206672
42MP0001545_abnormal_hematopoietic_system1.55206672
43MP0002429_abnormal_blood_cell1.55131512
44MP0009764_decreased_sensitivity_to1.43565554
45MP0003045_fibrosis1.42335990
46MP0001853_heart_inflammation1.41490390
47MP0001851_eye_inflammation1.40736322
48MP0003183_abnormal_peptide_metabolism1.37378970
49MP0002009_preneoplasia1.34737447
50MP0009763_increased_sensitivity_to1.23766326
51MP0008469_abnormal_protein_level1.21273333
52MP0003828_pulmonary_edema1.20624326
53MP0000858_altered_metastatic_potential1.18152975
54MP0005310_abnormal_salivary_gland1.16816747
55MP0000249_abnormal_blood_vessel1.15646011
56MP0008875_abnormal_xenobiotic_pharmacok1.14757328
57MP0003656_abnormal_erythrocyte_physiolo1.14146774
58MP0009278_abnormal_bone_marrow1.12569575
59MP0005164_abnormal_response_to1.12127977
60MP0005670_abnormal_white_adipose1.11092872
61MP0009765_abnormal_xenobiotic_induced1.11069964
62MP0004808_abnormal_hematopoietic_stem1.10278507
63MP0002933_joint_inflammation1.09910304
64MP0002138_abnormal_hepatobiliary_system1.08465351
65MP0002998_abnormal_bone_remodeling1.06412617
66MP0003075_altered_response_to1.04900814
67MP0003448_altered_tumor_morphology1.03971697
68MP0005165_increased_susceptibility_to0.96433908
69MP0001873_stomach_inflammation0.90236905
70MP0001663_abnormal_digestive_system0.89661423
71MP0003172_abnormal_lysosome_physiology0.89373564
72MP0005166_decreased_susceptibility_to0.88677858
73MP0004883_abnormal_blood_vessel0.87807080
74MP0005646_abnormal_pituitary_gland0.86349228
75MP0000343_altered_response_to0.82827080
76MP0002876_abnormal_thyroid_physiology0.82481585
77MP0005083_abnormal_biliary_tract0.82265843
78MP0004130_abnormal_muscle_cell0.82058359
79MP0008995_early_reproductive_senescence0.79417137
80MP0004185_abnormal_adipocyte_glucose0.77808374
81MP0003252_abnormal_bile_duct0.76657519
82MP0001765_abnormal_ion_homeostasis0.76084835
83MP0005666_abnormal_adipose_tissue0.74556120
84MP0005390_skeleton_phenotype0.74494435
85MP0004043_abnormal_pH_regulation0.73994596
86MP0002277_abnormal_respiratory_mucosa0.73892406
87MP0002019_abnormal_tumor_incidence0.73152249
88MP0002136_abnormal_kidney_physiology0.72088171
89MP0003806_abnormal_nucleotide_metabolis0.71823395
90MP0004381_abnormal_hair_follicle0.69750179
91MP0009643_abnormal_urine_homeostasis0.69289134
92MP0001661_extended_life_span0.67242996
93MP0005075_abnormal_melanosome_morpholog0.64744771
94MP0000230_abnormal_systemic_arterial0.64684649
95MP0002877_abnormal_melanocyte_morpholog0.63841375
96MP0008873_increased_physiological_sensi0.61370995
97MP0002168_other_aberrant_phenotype0.59910440
98MP0003795_abnormal_bone_structure0.58975126
99MP0004084_abnormal_cardiac_muscle0.58893788
100MP0000681_abnormal_thyroid_gland0.57256309

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)6.10341657
2Abnormal respiratory epithelium morphology (HP:0012253)6.10341657
3Absent/shortened dynein arms (HP:0200106)5.87791014
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.87791014
5Abnormal ciliary motility (HP:0012262)5.53256059
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.49848404
7Abnormal respiratory motile cilium physiology (HP:0012261)5.29686314
8Rhinitis (HP:0012384)4.76209398
9Nasal polyposis (HP:0100582)4.32816706
10Elevated erythrocyte sedimentation rate (HP:0003565)4.26464133
11Bronchiectasis (HP:0002110)4.25983074
12Prolonged bleeding time (HP:0003010)4.24403278
13Chronic sinusitis (HP:0011109)4.19119616
14Spontaneous hematomas (HP:0007420)4.13513067
15T lymphocytopenia (HP:0005403)3.95889291
16Autoimmune hemolytic anemia (HP:0001890)3.85887995
17Abnormality of T cell number (HP:0011839)3.85659982
18Chronic otitis media (HP:0000389)3.85449419
19Epistaxis (HP:0000421)3.75533562
20Abnormality of the nasal mucosa (HP:0000433)3.68740530
21Recurrent sinusitis (HP:0011108)3.67547704
22Chronic bronchitis (HP:0004469)3.48125105
23Bronchitis (HP:0012387)3.46369389
24Recurrent bronchitis (HP:0002837)3.45162335
25Purpura (HP:0000979)3.36227306
26Myositis (HP:0100614)3.33627052
27Granulocytopenia (HP:0001913)3.32130505
28Petechiae (HP:0000967)3.31536013
29Panhypogammaglobulinemia (HP:0003139)3.28248393
30Gingival bleeding (HP:0000225)3.24368854
31Abnormality of B cell number (HP:0010975)3.20341223
32Recurrent viral infections (HP:0004429)3.12641844
33Recurrent abscess formation (HP:0002722)3.07460333
34B lymphocytopenia (HP:0010976)2.94138683
35Abnormality of T cells (HP:0002843)2.92044666
36Recurrent fungal infections (HP:0002841)2.91572080
37Eosinophilia (HP:0001880)2.88379367
38Recurrent bacterial skin infections (HP:0005406)2.86719641
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.81750152
40Menorrhagia (HP:0000132)2.81252243
41Meningitis (HP:0001287)2.80435807
42Pulmonary embolism (HP:0002204)2.79002234
43Chronic diarrhea (HP:0002028)2.69871474
44Autoimmune thrombocytopenia (HP:0001973)2.67812341
45Arterial thrombosis (HP:0004420)2.65393209
46Vasculitis (HP:0002633)2.65282923
47Stomatitis (HP:0010280)2.64688709
48Abnormality of eosinophils (HP:0001879)2.64417827
49Severe combined immunodeficiency (HP:0004430)2.63838451
50Eczematoid dermatitis (HP:0000976)2.59725758
51Hypergammaglobulinemia (HP:0010702)2.57059641
52Recurrent otitis media (HP:0000403)2.55755223
53Agammaglobulinemia (HP:0004432)2.48352459
54Conjunctival telangiectasia (HP:0000524)2.46994769
55Increased IgM level (HP:0003496)2.46228503
56Leukocytosis (HP:0001974)2.46000990
57Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39612960
58Recurrent gram-negative bacterial infections (HP:0005420)2.39265633
59Hemoptysis (HP:0002105)2.37671226
60Abnormal platelet volume (HP:0011876)2.36542583
61Abnormality of the prostate (HP:0008775)2.34348881
62Constricted visual fields (HP:0001133)2.30047078
63Encephalitis (HP:0002383)2.28911002
64Abnormality of macrophages (HP:0004311)2.28083773
65Thyroiditis (HP:0100646)2.26444285
66Retrobulbar optic neuritis (HP:0100654)2.26052674
67Optic neuritis (HP:0100653)2.26052674
68Gastrointestinal infarctions (HP:0005244)2.24512304
69Increased mean platelet volume (HP:0011877)2.24504755
70Thrombophlebitis (HP:0004418)2.24072800
71Anorexia (HP:0002039)2.24056182
72Chest pain (HP:0100749)2.23272276
73Obstructive lung disease (HP:0006536)2.22767149
74Chronic obstructive pulmonary disease (HP:0006510)2.22767149
75Pulmonary infiltrates (HP:0002113)2.22098931
76Hypoproteinemia (HP:0003075)2.20222176
77Infertility (HP:0000789)2.18667110
78Pustule (HP:0200039)2.18647729
79IgG deficiency (HP:0004315)2.17461107
80Joint swelling (HP:0001386)2.16342199
81Orchitis (HP:0100796)2.15650082
82Hypoplasia of the thymus (HP:0000778)2.14791155
83Gangrene (HP:0100758)2.11257174
84IgM deficiency (HP:0002850)2.10670225
85Increased IgE level (HP:0003212)2.08750900
86Recurrent skin infections (HP:0001581)2.06688232
87Abnormality of T cell physiology (HP:0011840)2.04722325
88Interstitial pulmonary disease (HP:0006530)2.01018759
89Chronic mucocutaneous candidiasis (HP:0002728)2.00904160
90Recurrent cutaneous fungal infections (HP:0011370)2.00904160
91Combined immunodeficiency (HP:0005387)1.98822719
92Alveolar cell carcinoma (HP:0006519)1.97922995
93Inflammation of the large intestine (HP:0002037)1.93366940
94Neoplasm of the tracheobronchial system (HP:0100552)1.92583741
95Impaired platelet aggregation (HP:0003540)1.91552562
96Abnormal platelet function (HP:0011869)1.91552562
97Mediastinal lymphadenopathy (HP:0100721)1.88385934
98Esophageal varix (HP:0002040)1.88327606
99Abnormality of the fingertips (HP:0001211)1.87893391
100Colitis (HP:0002583)1.87186215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.95907413
2TXK3.86569939
3MAP4K13.36846664
4MST42.90288882
5TAOK32.59755322
6MAP2K32.53625780
7TEC2.49070663
8BTK2.47817812
9MAPK152.45103431
10BMPR22.35291822
11FES2.33882836
12ZAP702.31498578
13JAK32.29344016
14MAP3K32.26349971
15SYK2.18478346
16ITK2.14663669
17MAP3K142.03548292
18TBK11.93545250
19BLK1.89077083
20CSK1.82836731
21IKBKB1.82169563
22KIT1.79984919
23IKBKE1.72901522
24PIK3CG1.60794985
25TYK21.59442950
26CSF1R1.45207458
27JAK11.45175829
28GRK61.45035513
29LCK1.40648297
30HCK1.39481768
31LYN1.33979072
32MAPKAPK31.33142278
33PRKCQ1.27113252
34MYLK1.21657776
35MATK1.19402285
36KDR1.18148127
37FGR1.17262977
38TRPM71.17043563
39JAK21.10789575
40PRPF4B1.09457226
41TNK21.09257109
42CDK91.08377526
43MAP3K131.01769018
44NLK0.97476475
45IRAK10.94716734
46HIPK20.89924713
47IRAK40.87578362
48CDK60.86887923
49EPHA30.79685172
50STK100.79679165
51FGFR30.78676342
52RPS6KB20.75876052
53ACVR1B0.72520377
54PTK2B0.71256770
55PIK3CA0.67948920
56MAPK110.65975324
57MAP3K70.64862356
58GRK50.62083308
59STK240.59594852
60GRK70.59534376
61CAMKK20.58780694
62FYN0.56518732
63ERN10.56400362
64SGK20.56159429
65MAPK120.54566222
66CLK10.54286827
67TGFBR20.53320389
68TLK10.52429671
69PIM10.50899543
70CDK120.50445867
71ABL10.50147031
72PDK10.48801636
73EIF2AK30.48578400
74MAP3K110.44710455
75CHUK0.44453883
76MAP3K60.43893982
77RET0.42167984
78MARK30.41801566
79FRK0.39780846
80SCYL20.39691187
81MAP3K50.39314296
82MAP3K20.39026806
83SGK30.39016542
84SMG10.38987600
85IGF1R0.38939117
86MAP2K60.37234609
87MAP3K10.37169403
88EGFR0.36611597
89PRKCD0.36490794
90MAPKAPK20.35943926
91ADRBK10.35847836
92MAPK30.35256872
93PDGFRB0.35021058
94ILK0.34026155
95RPS6KA50.33771765
96NEK60.33386330
97MAPK70.32062522
98EPHB10.31223601
99RIPK10.30934843
100PRKD10.30899000

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.54820979
2Graft-versus-host disease_Homo sapiens_hsa053323.46897112
3Autoimmune thyroid disease_Homo sapiens_hsa053203.41011602
4Primary immunodeficiency_Homo sapiens_hsa053403.29505717
5Asthma_Homo sapiens_hsa053102.99943953
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.73571251
7Hematopoietic cell lineage_Homo sapiens_hsa046402.66531659
8Type I diabetes mellitus_Homo sapiens_hsa049402.55745229
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51176810
10Staphylococcus aureus infection_Homo sapiens_hsa051502.25028671
11Leishmaniasis_Homo sapiens_hsa051402.14722390
12Antigen processing and presentation_Homo sapiens_hsa046122.06733062
13Rheumatoid arthritis_Homo sapiens_hsa053231.92481453
14T cell receptor signaling pathway_Homo sapiens_hsa046601.91686257
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.82557459
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78534243
17Platelet activation_Homo sapiens_hsa046111.77215063
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72723510
19B cell receptor signaling pathway_Homo sapiens_hsa046621.71741696
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70187911
21Osteoclast differentiation_Homo sapiens_hsa043801.66300138
22Measles_Homo sapiens_hsa051621.62722042
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62352854
24Viral myocarditis_Homo sapiens_hsa054161.58024945
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.43657007
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40236500
27Chemokine signaling pathway_Homo sapiens_hsa040621.38249267
28Systemic lupus erythematosus_Homo sapiens_hsa053221.36365210
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32475182
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30744822
31Influenza A_Homo sapiens_hsa051641.28370763
32Herpes simplex infection_Homo sapiens_hsa051681.26030099
33Malaria_Homo sapiens_hsa051441.23474702
34Toxoplasmosis_Homo sapiens_hsa051451.20966130
35TNF signaling pathway_Homo sapiens_hsa046681.20863377
36Tuberculosis_Homo sapiens_hsa051521.12516425
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04442424
38Pertussis_Homo sapiens_hsa051330.98834975
39Legionellosis_Homo sapiens_hsa051340.98821156
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97211389
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97047387
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94919573
43Acute myeloid leukemia_Homo sapiens_hsa052210.94522217
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93594954
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91366332
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85667099
47African trypanosomiasis_Homo sapiens_hsa051430.84626399
48Arachidonic acid metabolism_Homo sapiens_hsa005900.84464178
49Chemical carcinogenesis_Homo sapiens_hsa052040.80284001
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79963533
51Salmonella infection_Homo sapiens_hsa051320.77347016
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75235155
53Phagosome_Homo sapiens_hsa041450.73083551
54Pancreatic cancer_Homo sapiens_hsa052120.72736733
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.72425299
56Non-small cell lung cancer_Homo sapiens_hsa052230.71665735
57Shigellosis_Homo sapiens_hsa051310.70513668
58Linoleic acid metabolism_Homo sapiens_hsa005910.70035722
59Apoptosis_Homo sapiens_hsa042100.69594624
60Collecting duct acid secretion_Homo sapiens_hsa049660.68589959
61Other glycan degradation_Homo sapiens_hsa005110.68373514
62Sulfur metabolism_Homo sapiens_hsa009200.66578823
63Hepatitis B_Homo sapiens_hsa051610.65265105
64Hepatitis C_Homo sapiens_hsa051600.58460805
65Viral carcinogenesis_Homo sapiens_hsa052030.57663087
66ABC transporters_Homo sapiens_hsa020100.56970552
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52942896
68Caffeine metabolism_Homo sapiens_hsa002320.52314927
69Chronic myeloid leukemia_Homo sapiens_hsa052200.51419598
70Regulation of autophagy_Homo sapiens_hsa041400.48842513
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48475307
72Lysosome_Homo sapiens_hsa041420.47841972
73HTLV-I infection_Homo sapiens_hsa051660.47840063
74Complement and coagulation cascades_Homo sapiens_hsa046100.45412316
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42489322
76Amoebiasis_Homo sapiens_hsa051460.41830035
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41379094
78Dorso-ventral axis formation_Homo sapiens_hsa043200.40936924
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.39370340
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.38696286
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38380260
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.37618314
83Serotonergic synapse_Homo sapiens_hsa047260.37061124
84Retinol metabolism_Homo sapiens_hsa008300.36994466
85Endocytosis_Homo sapiens_hsa041440.36991605
86Epstein-Barr virus infection_Homo sapiens_hsa051690.35416293
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34900427
88Prolactin signaling pathway_Homo sapiens_hsa049170.33276431
89Alcoholism_Homo sapiens_hsa050340.33147767
90Choline metabolism in cancer_Homo sapiens_hsa052310.33126354
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31979136
92Renin secretion_Homo sapiens_hsa049240.31440374
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30727806
94Tyrosine metabolism_Homo sapiens_hsa003500.30607332
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.29198816
96Sphingolipid metabolism_Homo sapiens_hsa006000.28347490
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27703325
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27622157
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.27001070
100Phenylalanine metabolism_Homo sapiens_hsa003600.25512201

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