CMBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.32798658
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.32798658
3L-phenylalanine metabolic process (GO:0006558)7.05407827
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.05407827
5aromatic amino acid family catabolic process (GO:0009074)6.50611773
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.86651080
7NADH metabolic process (GO:0006734)5.80463702
8indole-containing compound catabolic process (GO:0042436)5.75392929
9indolalkylamine catabolic process (GO:0046218)5.75392929
10tryptophan catabolic process (GO:0006569)5.75392929
11glyoxylate metabolic process (GO:0046487)5.70343422
12kynurenine metabolic process (GO:0070189)5.59699826
13bile acid biosynthetic process (GO:0006699)5.54997897
14tryptophan metabolic process (GO:0006568)5.46930095
15cysteine metabolic process (GO:0006534)5.43961148
16alpha-linolenic acid metabolic process (GO:0036109)5.41377333
17sulfur amino acid catabolic process (GO:0000098)5.33449686
18urea cycle (GO:0000050)5.21623771
19urea metabolic process (GO:0019627)5.21623771
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04980386
21high-density lipoprotein particle remodeling (GO:0034375)5.00607898
22lysine catabolic process (GO:0006554)4.98991088
23lysine metabolic process (GO:0006553)4.98991088
24serine family amino acid catabolic process (GO:0009071)4.98473881
25fructose metabolic process (GO:0006000)4.83518080
26homocysteine metabolic process (GO:0050667)4.82897348
27nitrogen cycle metabolic process (GO:0071941)4.82497720
28negative regulation of fibrinolysis (GO:0051918)4.82039863
29aromatic amino acid family metabolic process (GO:0009072)4.80628346
30amino-acid betaine metabolic process (GO:0006577)4.79187044
31bile acid metabolic process (GO:0008206)4.76233972
32complement activation, alternative pathway (GO:0006957)4.75619340
33peptidyl-glutamic acid carboxylation (GO:0017187)4.74890374
34protein carboxylation (GO:0018214)4.74890374
35tyrosine metabolic process (GO:0006570)4.70460773
36cellular ketone body metabolic process (GO:0046950)4.66788286
37regulation of triglyceride catabolic process (GO:0010896)4.66338282
38regulation of fibrinolysis (GO:0051917)4.61615641
39regulation of protein activation cascade (GO:2000257)4.59846015
40alpha-amino acid catabolic process (GO:1901606)4.55393030
41omega-hydroxylase P450 pathway (GO:0097267)4.53783372
42regulation of cholesterol esterification (GO:0010872)4.45413321
43reverse cholesterol transport (GO:0043691)4.38935958
44triglyceride homeostasis (GO:0070328)4.38900707
45acylglycerol homeostasis (GO:0055090)4.38900707
46phenylpropanoid metabolic process (GO:0009698)4.35883885
47protein-lipid complex remodeling (GO:0034368)4.35160855
48macromolecular complex remodeling (GO:0034367)4.35160855
49plasma lipoprotein particle remodeling (GO:0034369)4.35160855
50regulation of complement activation (GO:0030449)4.31332067
51oxaloacetate metabolic process (GO:0006107)4.29417801
52cellular amino acid catabolic process (GO:0009063)4.26843831
53coenzyme catabolic process (GO:0009109)4.23901247
54drug catabolic process (GO:0042737)4.21604742
55negative regulation of sterol transport (GO:0032372)4.20972466
56negative regulation of cholesterol transport (GO:0032375)4.20972466
57indolalkylamine metabolic process (GO:0006586)4.15245431
58phospholipid efflux (GO:0033700)4.14157637
59cellular glucuronidation (GO:0052695)4.13516221
60short-chain fatty acid metabolic process (GO:0046459)4.13038869
61creatine metabolic process (GO:0006600)4.11889848
62bile acid and bile salt transport (GO:0015721)4.09898259
63oxidative demethylation (GO:0070989)4.09490942
64plasma lipoprotein particle clearance (GO:0034381)4.08944576
65glutamate metabolic process (GO:0006536)4.07767937
66ethanol metabolic process (GO:0006067)4.07007534
67ketone body metabolic process (GO:1902224)4.04406468
68cellular modified amino acid catabolic process (GO:0042219)4.04078894
69serine family amino acid metabolic process (GO:0009069)4.04059255
70ethanol oxidation (GO:0006069)4.02672467
71benzene-containing compound metabolic process (GO:0042537)4.00233098
72glycine metabolic process (GO:0006544)4.00092859
73cellular biogenic amine catabolic process (GO:0042402)3.98871375
74amine catabolic process (GO:0009310)3.98871375
75acetyl-CoA metabolic process (GO:0006084)3.93126377
76fatty acid beta-oxidation (GO:0006635)3.90562001
77aldehyde catabolic process (GO:0046185)3.88864344
78carboxylic acid catabolic process (GO:0046395)3.87392149
79organic acid catabolic process (GO:0016054)3.87392149
80drug transmembrane transport (GO:0006855)3.86730876
81fatty acid oxidation (GO:0019395)3.83600596
82dicarboxylic acid biosynthetic process (GO:0043650)3.78524287
83imidazole-containing compound metabolic process (GO:0052803)3.78055955
84lipid oxidation (GO:0034440)3.77633319
85cholesterol efflux (GO:0033344)3.76874502
86monocarboxylic acid catabolic process (GO:0072329)3.76584334
87glucuronate metabolic process (GO:0019585)3.76109447
88uronic acid metabolic process (GO:0006063)3.76109447
89arginine metabolic process (GO:0006525)3.75358521
90aspartate family amino acid catabolic process (GO:0009068)3.73257192
91serine family amino acid biosynthetic process (GO:0009070)3.72821029
92fat-soluble vitamin biosynthetic process (GO:0042362)3.72350928
93fatty acid catabolic process (GO:0009062)3.72089672
942-oxoglutarate metabolic process (GO:0006103)3.71885668
95exogenous drug catabolic process (GO:0042738)3.71567584
96daunorubicin metabolic process (GO:0044597)3.71126705
97polyketide metabolic process (GO:0030638)3.71126705
98doxorubicin metabolic process (GO:0044598)3.71126705
99carnitine metabolic process (GO:0009437)3.70521209
100urate metabolic process (GO:0046415)3.69913077
101hormone catabolic process (GO:0042447)3.66469266
102positive regulation of lipid catabolic process (GO:0050996)3.65275325
103regulation of bile acid biosynthetic process (GO:0070857)3.64597199
104low-density lipoprotein particle remodeling (GO:0034374)3.61114325
105flavonoid metabolic process (GO:0009812)3.60608410
106intestinal absorption (GO:0050892)3.60091979
107plasma lipoprotein particle assembly (GO:0034377)3.58165304
108drug metabolic process (GO:0017144)3.58144876
109phospholipid homeostasis (GO:0055091)3.57425142
110epoxygenase P450 pathway (GO:0019373)3.56960524
111cholesterol homeostasis (GO:0042632)3.54493514
112regulation of cholesterol homeostasis (GO:2000188)3.53259945
113cofactor catabolic process (GO:0051187)3.53212217
114proline metabolic process (GO:0006560)3.52092518
115positive regulation of triglyceride lipase activity (GO:0061365)3.51672097
116positive regulation of lipoprotein lipase activity (GO:0051006)3.51672097
117S-adenosylmethionine metabolic process (GO:0046500)3.48455890
118quinone biosynthetic process (GO:1901663)3.44130814
119angiotensin maturation (GO:0002003)3.43835152
120aminoglycoside antibiotic metabolic process (GO:0030647)3.43693818
121alkaloid metabolic process (GO:0009820)3.41796124
122glutamine family amino acid biosynthetic process (GO:0009084)3.40450734
123tricarboxylic acid cycle (GO:0006099)3.39747486
124heme transport (GO:0015886)3.37728762
125gluconeogenesis (GO:0006094)3.29126541
126quinone metabolic process (GO:1901661)3.22893741
127arginine catabolic process (GO:0006527)3.22644648
128very-low-density lipoprotein particle assembly (GO:0034379)3.18540839
129xenobiotic catabolic process (GO:0042178)3.14235403
130primary alcohol catabolic process (GO:0034310)3.13110983
131vitamin biosynthetic process (GO:0009110)3.08875507
132blood coagulation, intrinsic pathway (GO:0007597)3.08538826
133hexose biosynthetic process (GO:0019319)3.06824143
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.06121516
135muscle filament sliding (GO:0030049)3.02538952
136actin-myosin filament sliding (GO:0033275)3.02538952
137L-methionine salvage (GO:0071267)3.01053487
138L-methionine biosynthetic process (GO:0071265)3.01053487
139amino acid salvage (GO:0043102)3.01053487
140succinate metabolic process (GO:0006105)2.99284588
141proline biosynthetic process (GO:0006561)2.97902284
142xenobiotic metabolic process (GO:0006805)2.97437182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.99485405
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.85822555
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.31713555
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.21815404
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.84226524
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.01133006
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66852047
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.84287486
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59263273
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57420457
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11673791
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2109315
13* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98415212
14CLOCK_20551151_ChIP-Seq_293T_Human1.87670920
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.57028595
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54531075
17GATA1_22025678_ChIP-Seq_K562_Human1.49080891
18SRF_21415370_ChIP-Seq_HL-1_Mouse1.48544374
19HTT_18923047_ChIP-ChIP_STHdh_Human1.43379786
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.40596751
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35978624
22BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29639587
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28490126
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27232846
25AR_21909140_ChIP-Seq_LNCAP_Human1.26822087
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25206656
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22258580
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22091389
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18051661
30CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17610501
31PHF8_20622853_ChIP-Seq_HELA_Human1.15443124
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14730824
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14444447
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13717190
35HNFA_21074721_ChIP-Seq_CACO-2_Human1.08667974
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08504469
37RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06915556
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05674053
39GATA6_21074721_ChIP-Seq_CACO-2_Human1.04184767
40ZNF263_19887448_ChIP-Seq_K562_Human1.02539901
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01689462
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01238266
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98634800
44CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94498595
45GATA4_25053715_ChIP-Seq_YYC3_Human0.93332351
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93159458
47SA1_27219007_Chip-Seq_Bcells_Human0.91445091
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89872685
49ESR2_21235772_ChIP-Seq_MCF-7_Human0.89173793
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88535763
51TET1_21451524_ChIP-Seq_MESCs_Mouse0.87367906
52CTCF_27219007_Chip-Seq_Bcells_Human0.86176690
53E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85214223
54HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85105676
55SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84231712
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83956961
57RBPJ_21746931_ChIP-Seq_IB4_Human0.83831815
58AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83289467
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82843401
60MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82205541
61MYC_18555785_ChIP-Seq_MESCs_Mouse0.81680679
62ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80259847
63ERG_20517297_ChIP-Seq_VCAP_Human0.79454393
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78616498
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78511704
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78187758
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77973308
68VDR_22108803_ChIP-Seq_LS180_Human0.77892986
69NANOG_20526341_ChIP-Seq_ESCs_Human0.77185340
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76580197
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76580197
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75881308
73* RACK7_27058665_Chip-Seq_MCF-7_Human0.75409277
74NCOR_22424771_ChIP-Seq_293T_Human0.74551426
75NFYB_21822215_ChIP-Seq_K562_Human0.74040768
76NFYA_21822215_ChIP-Seq_K562_Human0.73881163
77RAC3_21632823_ChIP-Seq_H3396_Human0.72863373
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72814669
79SOX2_21211035_ChIP-Seq_LN229_Human0.72621160
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.71686439
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.71554776
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71464579
83* E2F1_20622854_ChIP-Seq_HELA_Human0.71405209
84KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70706166
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69666116
86CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69562594
87PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69342564
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69039174
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69018849
90* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68987502
91RARA_24833708_ChIP-Seq_LIVER_Mouse0.68262572
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66907674
93CDX2_20551321_ChIP-Seq_CACO-2_Human0.65476722
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64903805
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63220076
96* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62047128
97CEBPB_22108803_ChIP-Seq_LS180_Human0.60357430
98BCAT_22108803_ChIP-Seq_LS180_Human0.60268956
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59615361
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59002698
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58429432
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58373173
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57181311
104PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57076324
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56416479
106* AR_20517297_ChIP-Seq_VCAP_Human0.56116214
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.55699731
108MYC_19915707_ChIP-ChIP_AK7_Human0.55112898
109RARB_24833708_ChIP-Seq_LIVER_Mouse0.54726714
110CBP_21632823_ChIP-Seq_H3396_Human0.54656253
111* LXR_22292898_ChIP-Seq_THP-1_Human0.54424879
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.54255952
113EGR1_19032775_ChIP-ChIP_M12_Human0.54000285
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53629488
115ESET_19884257_ChIP-Seq_ESCs_Mouse0.52526184
116* FOXA1_25552417_ChIP-Seq_VCAP_Human0.52132960
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50412763
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49912891
119SOX2_20726797_ChIP-Seq_SW620_Human0.49908168
120IRF8_22096565_ChIP-ChIP_GC-B_Human0.49669938
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49002801
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47710356
123GATA6_25053715_ChIP-Seq_YYC3_Human0.47596198
124STAT1_17558387_ChIP-Seq_HELA_Human0.47326209
125TAF2_19829295_ChIP-Seq_ESCs_Human0.47118714
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.47061206
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.46174675
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46057026
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45539680
130* P53_21459846_ChIP-Seq_SAOS-2_Human0.44503538
131* GATA2_19941826_ChIP-Seq_K562_Human0.43875370
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.43673028
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.42802715
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.42802715
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42494433
136CDX2_22108803_ChIP-Seq_LS180_Human0.42237090
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41211651
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.40855510
139TAF15_26573619_Chip-Seq_HEK293_Human0.40835036
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.40587204
141FOXH1_21741376_ChIP-Seq_EPCs_Human0.40207447
142* GATA1_19941826_ChIP-Seq_K562_Human0.40119370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.08488539
2MP0005360_urolithiasis7.47117619
3MP0005085_abnormal_gallbladder_physiolo6.10459902
4MP0005365_abnormal_bile_salt5.89429564
5MP0008875_abnormal_xenobiotic_pharmacok4.99669525
6MP0003806_abnormal_nucleotide_metabolis4.05370228
7MP0003252_abnormal_bile_duct3.73464754
8MP0010329_abnormal_lipoprotein_level3.51054475
9MP0004147_increased_porphyrin_level3.33615945
10MP0005332_abnormal_amino_acid3.07235454
11MP0004145_abnormal_muscle_electrophysio3.06681795
12MP0009840_abnormal_foam_cell3.06619273
13MP0003195_calcinosis2.98122669
14MP0005083_abnormal_biliary_tract2.75646616
15MP0001666_abnormal_nutrient_absorption2.55771508
16MP0003646_muscle_fatigue2.52768680
17MP0004019_abnormal_vitamin_homeostasis2.31873573
18MP0003191_abnormal_cellular_cholesterol2.20315735
19MP0002118_abnormal_lipid_homeostasis2.17312379
20MP0000609_abnormal_liver_physiology2.07233808
21MP0002138_abnormal_hepatobiliary_system2.00622270
22MP0000749_muscle_degeneration1.95795357
23MP0005319_abnormal_enzyme/_coenzyme1.86585667
24MP0000751_myopathy1.77989699
25MP0003868_abnormal_feces_composition1.74314569
26MP0001764_abnormal_homeostasis1.71032381
27MP0005584_abnormal_enzyme/coenzyme_acti1.64335844
28MP0009643_abnormal_urine_homeostasis1.58530316
29MP0003186_abnormal_redox_activity1.46683309
30MP0005670_abnormal_white_adipose1.45418705
31MP0005451_abnormal_body_composition1.44369859
32MP0009697_abnormal_copulation1.37688194
33MP0003879_abnormal_hair_cell1.32235225
34MP0000747_muscle_weakness1.31361307
35MP0004036_abnormal_muscle_relaxation1.30419561
36MP0004130_abnormal_muscle_cell1.21568542
37MP0006036_abnormal_mitochondrial_physio1.16139308
38MP0005636_abnormal_mineral_homeostasis1.15552731
39MP0003656_abnormal_erythrocyte_physiolo1.14890832
40MP0003011_delayed_dark_adaptation1.14555941
41MP0002876_abnormal_thyroid_physiology1.13427539
42MP0002837_dystrophic_cardiac_calcinosis1.12094003
43MP0002106_abnormal_muscle_physiology1.08872968
44MP0000598_abnormal_liver_morphology1.07409536
45MP0003705_abnormal_hypodermis_morpholog1.07212245
46MP0004233_abnormal_muscle_weight1.04487020
47MP0004087_abnormal_muscle_fiber1.03585136
48MP0009379_abnormal_foot_pigmentation1.03296020
49MP0005647_abnormal_sex_gland0.98462433
50MP0002822_catalepsy0.98087075
51MP0001756_abnormal_urination0.96536068
52MP0000759_abnormal_skeletal_muscle0.95564572
53MP0009764_decreased_sensitivity_to0.95154774
54MP0010234_abnormal_vibrissa_follicle0.94702170
55MP0000604_amyloidosis0.94621259
56MP0005535_abnormal_body_temperature0.94501021
57MP0002078_abnormal_glucose_homeostasis0.94471278
58MP0009780_abnormal_chondrocyte_physiolo0.93604172
59MP0002971_abnormal_brown_adipose0.92803286
60MP0005369_muscle_phenotype0.90897091
61MP0005187_abnormal_penis_morphology0.90383517
62MP0008775_abnormal_heart_ventricle0.90123173
63MP0009642_abnormal_blood_homeostasis0.89319449
64MP0005620_abnormal_muscle_contractility0.88275883
65MP0005666_abnormal_adipose_tissue0.87401469
66MP0000013_abnormal_adipose_tissue0.86991332
67MP0004043_abnormal_pH_regulation0.86089935
68MP0009763_increased_sensitivity_to0.85967682
69MP0001664_abnormal_digestion0.85480801
70MP0000678_abnormal_parathyroid_gland0.84078960
71MP0001661_extended_life_span0.82432188
72MP0005334_abnormal_fat_pad0.81563211
73MP0005408_hypopigmentation0.81200000
74MP0005376_homeostasis/metabolism_phenot0.81018210
75MP0005084_abnormal_gallbladder_morpholo0.78861346
76MP0008469_abnormal_protein_level0.78599799
77MP0002254_reproductive_system_inflammat0.78315868
78MP0002332_abnormal_exercise_endurance0.78042460
79MP0005266_abnormal_metabolism0.74317076
80MP0003690_abnormal_glial_cell0.74024447
81MP0003183_abnormal_peptide_metabolism0.73415026
82MP0004215_abnormal_myocardial_fiber0.72613386
83MP0006035_abnormal_mitochondrial_morpho0.72544129
84MP0000750_abnormal_muscle_regeneration0.67946081
85MP0010368_abnormal_lymphatic_system0.67151706
86MP0003329_amyloid_beta_deposits0.65734834
87MP0009765_abnormal_xenobiotic_induced0.65335932
88MP0002136_abnormal_kidney_physiology0.65094911
89MP0000003_abnormal_adipose_tissue0.63024138
90MP0005220_abnormal_exocrine_pancreas0.62802187
91MP0005448_abnormal_energy_balance0.62205227
92MP0002249_abnormal_larynx_morphology0.61359935
93MP0002972_abnormal_cardiac_muscle0.59886569
94MP0000462_abnormal_digestive_system0.57628464
95MP0000230_abnormal_systemic_arterial0.57054390
96MP0005385_cardiovascular_system_phenoty0.56406038
97MP0001544_abnormal_cardiovascular_syste0.56406038
98MP0003953_abnormal_hormone_level0.54880773
99MP0004084_abnormal_cardiac_muscle0.54111566
100MP0006138_congestive_heart_failure0.52850080
101MP0001765_abnormal_ion_homeostasis0.52444800
102MP0000639_abnormal_adrenal_gland0.51059130
103MP0003638_abnormal_response/metabolism_0.50829009
104MP0004484_altered_response_of0.48867783
105MP0005058_abnormal_lysosome_morphology0.48701182
106MP0009115_abnormal_fat_cell0.47719059
107MP0008872_abnormal_physiological_respon0.47595015
108MP0005395_other_phenotype0.45071304
109MP0008874_decreased_physiological_sensi0.44670171
110MP0000538_abnormal_urinary_bladder0.43549675
111MP0002928_abnormal_bile_duct0.42068351
112MP0009053_abnormal_anal_canal0.42056710
113MP0004185_abnormal_adipocyte_glucose0.41024756
114MP0002796_impaired_skin_barrier0.40866048
115MP0005375_adipose_tissue_phenotype0.40046320
116MP0002970_abnormal_white_adipose0.39709170
117MP0004782_abnormal_surfactant_physiolog0.38993582
118MP0002269_muscular_atrophy0.38970345
119MP0002168_other_aberrant_phenotype0.38870141
120MP0008873_increased_physiological_sensi0.38079865
121MP0003724_increased_susceptibility_to0.36619564
122MP0009672_abnormal_birth_weight0.33445482
123MP0003959_abnormal_lean_body0.33299933
124MP0004264_abnormal_extraembryonic_tissu0.32257349
125MP0003075_altered_response_to0.32215562
126MP0000249_abnormal_blood_vessel0.31826454
127MP0005330_cardiomyopathy0.31474962
128MP0003718_maternal_effect0.31082165
129MP0001881_abnormal_mammary_gland0.30437080
130MP0005166_decreased_susceptibility_to0.30309810
131MP0009384_cardiac_valve_regurgitation0.29995395
132MP0005464_abnormal_platelet_physiology0.29734366
133MP0005167_abnormal_blood-brain_barrier0.29351883
134MP0005595_abnormal_vascular_smooth0.25983476
135MP0005248_abnormal_Harderian_gland0.25838039

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.04538266
2Intrahepatic cholestasis (HP:0001406)6.60993915
3Deep venous thrombosis (HP:0002625)6.38533923
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.07692192
5Xanthomatosis (HP:0000991)5.94841285
6Hypobetalipoproteinemia (HP:0003563)5.65373468
7Prolonged partial thromboplastin time (HP:0003645)5.52201796
8Hyperlipoproteinemia (HP:0010980)5.19917122
9Muscle fiber inclusion bodies (HP:0100299)5.10991450
10Nemaline bodies (HP:0003798)5.00047004
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.78196219
12Hyperammonemia (HP:0001987)4.74080330
13Hyperglycinuria (HP:0003108)4.66393392
14Complement deficiency (HP:0004431)4.60170310
15Hyperglycinemia (HP:0002154)4.57176585
16Ketosis (HP:0001946)4.55204735
17Exercise-induced myalgia (HP:0003738)4.49471641
18Hypolipoproteinemia (HP:0010981)4.43282088
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.43250056
20Abnormality of serine family amino acid metabolism (HP:0010894)4.40405330
21Abnormality of glycine metabolism (HP:0010895)4.40405330
22Hypoglycemic coma (HP:0001325)4.22352934
23Epidermoid cyst (HP:0200040)4.15577024
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12909439
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.07600859
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.05309540
27Hypoalphalipoproteinemia (HP:0003233)4.03657824
28Joint hemorrhage (HP:0005261)4.02472012
29Exercise-induced muscle cramps (HP:0003710)3.97609871
30Rhabdomyolysis (HP:0003201)3.96288799
31Abnormality of methionine metabolism (HP:0010901)3.88779666
32Abnormality of fatty-acid metabolism (HP:0004359)3.83805832
33Abnormality of the common coagulation pathway (HP:0010990)3.78849090
34Fat malabsorption (HP:0002630)3.72867541
35Myopathic facies (HP:0002058)3.62726207
36Ketoacidosis (HP:0001993)3.62106968
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51548327
38Type 1 muscle fiber predominance (HP:0003803)3.48053849
39Conjugated hyperbilirubinemia (HP:0002908)3.37754345
40Abnormality of pyrimidine metabolism (HP:0004353)3.35659399
41Abnormality of the intrinsic pathway (HP:0010989)3.27465938
42Abnormality of complement system (HP:0005339)3.26237742
43Hypercholesterolemia (HP:0003124)3.25853564
44Muscle hypertrophy of the lower extremities (HP:0008968)3.20565311
45Abnormality of nucleobase metabolism (HP:0010932)3.20133816
46Gout (HP:0001997)3.17885862
47Abnormality of serum amino acid levels (HP:0003112)3.15236484
48Abnormality of purine metabolism (HP:0004352)3.12371025
49Delayed CNS myelination (HP:0002188)3.12060074
50Hyperbilirubinemia (HP:0002904)3.11674446
51Dicarboxylic aciduria (HP:0003215)3.09729247
52Abnormality of dicarboxylic acid metabolism (HP:0010995)3.09729247
53Metabolic acidosis (HP:0001942)3.05495424
54Increased serum pyruvate (HP:0003542)3.00759470
55Abnormality of glycolysis (HP:0004366)2.98033643
56Lethargy (HP:0001254)2.91978394
57Distal arthrogryposis (HP:0005684)2.83904823
58Generalized aminoaciduria (HP:0002909)2.80729616
59Calf muscle hypertrophy (HP:0008981)2.77276712
60Cerebral edema (HP:0002181)2.77238634
61Hepatocellular carcinoma (HP:0001402)2.74719647
62Steatorrhea (HP:0002570)2.74478681
63Skin nodule (HP:0200036)2.71118741
64Acute encephalopathy (HP:0006846)2.67220521
65Myocardial infarction (HP:0001658)2.59826982
66Ileus (HP:0002595)2.58582960
67Hypoglycemic seizures (HP:0002173)2.57673417
68Vascular calcification (HP:0004934)2.54050555
69Proximal tubulopathy (HP:0000114)2.47111806
70Neonatal onset (HP:0003623)2.46427519
71Irritability (HP:0000737)2.44571773
72Hyperphosphaturia (HP:0003109)2.42865783
73Muscle stiffness (HP:0003552)2.41044488
74Vomiting (HP:0002013)2.40650759
75Malnutrition (HP:0004395)2.37687299
76Spontaneous abortion (HP:0005268)2.36012463
77Abnormal gallbladder morphology (HP:0012437)2.35660469
78Systemic lupus erythematosus (HP:0002725)2.34105219
79Cerebral palsy (HP:0100021)2.33842686
80Sensorimotor neuropathy (HP:0007141)2.33708988
81Hyperuricemia (HP:0002149)2.31736452
82Increased purine levels (HP:0004368)2.31736452
83Round ear (HP:0100830)2.31051457
84Alkalosis (HP:0001948)2.29574480
85Hepatic necrosis (HP:0002605)2.29030693
86EMG: myopathic abnormalities (HP:0003458)2.29001027
87Hydroxyprolinuria (HP:0003080)2.28503165
88Abnormality of proline metabolism (HP:0010907)2.28503165
89Cholelithiasis (HP:0001081)2.28125604
90Late onset (HP:0003584)2.27997239
91Reduced antithrombin III activity (HP:0001976)2.26525618
92Cardiovascular calcification (HP:0011915)2.25003231
93Hypochromic microcytic anemia (HP:0004840)2.24850119
94Spastic diplegia (HP:0001264)2.24114546
95Confusion (HP:0001289)2.23104409
96Pancreatitis (HP:0001733)2.23090286
97Glycosuria (HP:0003076)2.22490774
98Abnormality of urine glucose concentration (HP:0011016)2.22490774
99Ulnar deviation of the wrist (HP:0003049)2.21788856
100Enlarged kidneys (HP:0000105)2.19490190
101Abnormality of the vitamin B12 metabolism (HP:0004341)2.18989078
102Abnormality of vitamin B metabolism (HP:0004340)2.18742369
103Hyperinsulinemic hypoglycemia (HP:0000825)2.18531218
104Absent phalangeal crease (HP:0006109)2.16562211
105Cholecystitis (HP:0001082)2.16346184
106Abnormal gallbladder physiology (HP:0012438)2.16346184
107Brushfield spots (HP:0001088)2.15061784
108Abnormal urine phosphate concentration (HP:0012599)2.14480173
109Reticulocytosis (HP:0001923)2.14139004
110Abnormal mitochondria in muscle tissue (HP:0008316)2.13480142
111Calcaneovalgus deformity (HP:0001848)2.10662784
112Abnormality of alanine metabolism (HP:0010916)2.09016734
113Hyperalaninemia (HP:0003348)2.09016734
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09016734
115Acanthocytosis (HP:0001927)2.08762368
116Increased muscle lipid content (HP:0009058)2.08311307
117Poikilocytosis (HP:0004447)2.06287911
118Mitral stenosis (HP:0001718)2.05622266
119Hyperactive renin-angiotensin system (HP:0000841)2.05392947
120Rickets (HP:0002748)2.05161820
121Rimmed vacuoles (HP:0003805)2.04744790
122Myoglobinuria (HP:0002913)2.00794835
123Glomerulonephritis (HP:0000099)2.00670895
124Deformed tarsal bones (HP:0008119)2.00327369
125Acute necrotizing encephalopathy (HP:0006965)1.99669350
126Abnormality of the calf musculature (HP:0001430)1.98388466
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.97941838
128Abnormal cartilage morphology (HP:0002763)1.96561107
129Nausea (HP:0002018)1.95431881
130Renal cortical cysts (HP:0000803)1.95391803
131Amyloidosis (HP:0011034)1.93420049
132Esophageal varix (HP:0002040)1.92596783
133Abnormality of the gallbladder (HP:0005264)1.91070582
134Opisthotonus (HP:0002179)1.90011900
135Hyperglycemia (HP:0003074)1.87752041
136Abnormal enzyme/coenzyme activity (HP:0012379)1.83514667
137Symptomatic seizures (HP:0011145)1.83173897
138Hemorrhage of the eye (HP:0011885)1.83002539
139Abnormality of vitamin metabolism (HP:0100508)1.82184444
140Hypophosphatemic rickets (HP:0004912)1.81105565
141Hypertriglyceridemia (HP:0002155)1.77459602
142Elevated hepatic transaminases (HP:0002910)1.76657076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.41332309
2SIK14.00736760
3FGFR43.79178787
4ERN13.42345797
5INSRR3.32788232
6ACVR1B2.58229973
7EPHA22.44548968
8MST1R2.44486609
9TRIB32.35517293
10TAOK32.33206667
11MAPKAPK32.16834762
12MAP2K42.11953043
13ERBB42.11541844
14PKN21.97578982
15EIF2AK11.91534668
16NME11.90344471
17STK391.85555817
18FRK1.74777806
19FLT31.73529225
20PIK3CG1.71667036
21MAPK111.60831633
22EEF2K1.60522363
23PINK11.57070487
24PDK31.51268480
25PDK41.51268480
26WNK41.49144282
27PRKAA21.41394299
28ABL21.36064186
29LATS11.35093570
30NEK91.34435577
31STK38L1.33978381
32MAP4K21.28627842
33PRKG21.26152368
34PBK1.26055289
35PTK61.25512024
36BRSK21.24343826
37MAP3K71.23478669
38PIM21.22338880
39MST41.20278650
40DAPK21.20111982
41MUSK1.15865057
42CAMK1D1.14986608
43TYK21.13306238
44TNIK1.10273880
45MET1.09957613
46TIE11.07209262
47VRK21.07119732
48MAP2K31.04140439
49STK161.00722321
50JAK21.00148932
51FGFR20.98784028
52OBSCN0.96633512
53SCYL20.94942689
54GRK60.94931856
55KDR0.94055877
56MAPK120.93877531
57IRAK30.92654717
58WNK30.92556622
59EPHB20.92549153
60NME20.92435866
61PRKAA10.91465586
62TRPM70.91268225
63TTK0.89402649
64FER0.89164324
65MAP3K30.88328424
66MAP3K120.88310796
67CAMK1G0.87923242
68PDK20.87607005
69MAPK40.84479941
70CAMK2G0.84353906
71RPS6KB20.83550881
72ERBB30.82785952
73PRKACG0.82616367
74PRKCZ0.79719433
75CAMK2D0.77903516
76MAPK150.77832648
77AKT20.76761746
78MAP2K10.76690103
79ERBB20.76137002
80JAK10.75907757
81SGK30.74267968
82LIMK10.73736903
83GSK3A0.73047790
84NTRK10.72508094
85PDPK10.71235998
86SGK4940.71076903
87SGK2230.71076903
88CCNB10.70392541
89TBK10.68989500
90MAP2K60.68498165
91OXSR10.68065815
92EPHB10.68007576
93MAP3K110.67486364
94MYLK0.66078596
95PRKCI0.65846372
96MAPKAPK50.64095972
97TESK10.63205888
98SGK20.62810291
99PTK20.62326174
100RIPK10.62284322
101PIK3CA0.61420179
102MAP3K20.58865129
103EPHA30.57488960
104NEK10.55794270
105PAK30.52497478
106MAP2K20.50675623
107CDK60.48689228
108ICK0.48271413
109WEE10.48225317
110MAPK70.47314206
111PHKG10.47223925
112PHKG20.47223925
113FGFR30.47130482
114TGFBR20.46257640
115RET0.45774382
116IGF1R0.45118356
117BMX0.44487994
118DYRK1B0.43961075
119CSNK1G10.42742263
120LMTK20.41051327
121PDK10.40591214
122PRKCQ0.39946047
123PRKCG0.37838138
124PRKG10.37297790
125CSNK2A20.37004890
126CAMK2B0.36632622
127NUAK10.36425326
128MAP3K140.36381531
129IRAK10.35493502
130GRK10.35048812
131CSNK1E0.34796853
132CSNK1A10.34578975
133CSK0.34471316
134MAP3K10.33974363
135TTN0.33779914
136IRAK20.33124697
137ARAF0.32660377
138PRKCA0.30782492
139EIF2AK30.30486975
140PRKACA0.29983274
141MAP3K50.29091697
142MAP3K100.28896647
143KSR20.28296859
144AKT30.28242992
145CSNK2A10.27640406
146STK30.26695133
147PRKACB0.26249353
148RPS6KB10.25873556
149CAMK2A0.25430864
150RAF10.24465776
151DYRK30.23897860
152ILK0.22087122

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.05970233
2Nitrogen metabolism_Homo sapiens_hsa009103.35156328
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24884401
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15490330
5Arginine biosynthesis_Homo sapiens_hsa002202.85291589
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72750088
7Tryptophan metabolism_Homo sapiens_hsa003802.71872376
8Fatty acid degradation_Homo sapiens_hsa000712.68435401
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67666412
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57638210
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43119050
12Butanoate metabolism_Homo sapiens_hsa006502.36706608
13Propanoate metabolism_Homo sapiens_hsa006402.32175542
14Complement and coagulation cascades_Homo sapiens_hsa046102.28950255
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26830787
16Peroxisome_Homo sapiens_hsa041462.15987256
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09715367
18PPAR signaling pathway_Homo sapiens_hsa033201.99768466
19Fatty acid metabolism_Homo sapiens_hsa012121.99558310
20Histidine metabolism_Homo sapiens_hsa003401.88261798
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86234424
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83639837
23Chemical carcinogenesis_Homo sapiens_hsa052041.83315632
24beta-Alanine metabolism_Homo sapiens_hsa004101.79591349
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79213657
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.78240593
27Phenylalanine metabolism_Homo sapiens_hsa003601.66521974
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62869825
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61353669
30Caffeine metabolism_Homo sapiens_hsa002321.60954277
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.60707286
32Pyruvate metabolism_Homo sapiens_hsa006201.59805457
33Sulfur metabolism_Homo sapiens_hsa009201.56421441
34Retinol metabolism_Homo sapiens_hsa008301.55350505
35Tyrosine metabolism_Homo sapiens_hsa003501.51636541
36Bile secretion_Homo sapiens_hsa049761.50816795
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45730501
38Selenocompound metabolism_Homo sapiens_hsa004501.44171314
39Fatty acid elongation_Homo sapiens_hsa000621.39722377
40Staphylococcus aureus infection_Homo sapiens_hsa051501.37537151
41Starch and sucrose metabolism_Homo sapiens_hsa005001.35179393
42Carbon metabolism_Homo sapiens_hsa012001.31723555
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.21873579
44Folate biosynthesis_Homo sapiens_hsa007901.20684920
45Fat digestion and absorption_Homo sapiens_hsa049751.19171102
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18957469
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11788676
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07442941
49ABC transporters_Homo sapiens_hsa020101.07432731
50Steroid biosynthesis_Homo sapiens_hsa001001.06041973
51Arginine and proline metabolism_Homo sapiens_hsa003301.05441665
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04363399
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.03001745
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.02881246
55Vitamin digestion and absorption_Homo sapiens_hsa049770.91025140
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86648287
57Sulfur relay system_Homo sapiens_hsa041220.86295149
58Glycerolipid metabolism_Homo sapiens_hsa005610.85328754
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82267121
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81550496
61Vitamin B6 metabolism_Homo sapiens_hsa007500.79548878
62Lysine degradation_Homo sapiens_hsa003100.79488229
63Glutathione metabolism_Homo sapiens_hsa004800.73700183
64Pentose phosphate pathway_Homo sapiens_hsa000300.64526343
65Fatty acid biosynthesis_Homo sapiens_hsa000610.62153931
66Cardiac muscle contraction_Homo sapiens_hsa042600.55294557
67* Metabolic pathways_Homo sapiens_hsa011000.51265631
68Fructose and mannose metabolism_Homo sapiens_hsa000510.45085394
69One carbon pool by folate_Homo sapiens_hsa006700.44899377
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36639184
71Galactose metabolism_Homo sapiens_hsa000520.35380326
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34619905
73Huntingtons disease_Homo sapiens_hsa050160.33376532
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.30793734
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29486478
76Insulin resistance_Homo sapiens_hsa049310.28503416
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24175146
78Linoleic acid metabolism_Homo sapiens_hsa005910.23300217
79Prion diseases_Homo sapiens_hsa050200.22239013
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.21723094
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21168420
82Glucagon signaling pathway_Homo sapiens_hsa049220.17645156
83Circadian rhythm_Homo sapiens_hsa047100.17014119
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16092105
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14655800
86AMPK signaling pathway_Homo sapiens_hsa041520.13150610
87Ether lipid metabolism_Homo sapiens_hsa005650.12911454
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12638956
89Purine metabolism_Homo sapiens_hsa002300.10960314
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10477470
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09632610
92Sphingolipid metabolism_Homo sapiens_hsa006000.04882574
93Oxidative phosphorylation_Homo sapiens_hsa001900.00399553
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2072838
95Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2044280
96African trypanosomiasis_Homo sapiens_hsa05143-0.2029391
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1983039
98Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1884337
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1487809
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1423082
101Protein digestion and absorption_Homo sapiens_hsa04974-0.1351399
102Alzheimers disease_Homo sapiens_hsa05010-0.1146494
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0969722
104Renin-angiotensin system_Homo sapiens_hsa04614-0.0839714
105Mineral absorption_Homo sapiens_hsa04978-0.0829295
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0742987
107Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0691195
108Parkinsons disease_Homo sapiens_hsa05012-0.0630361
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0616812
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0294794
111Regulation of autophagy_Homo sapiens_hsa04140-0.0280571
112Insulin signaling pathway_Homo sapiens_hsa04910-0.0132102

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