CMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.12391928
2ribosomal small subunit biogenesis (GO:0042274)5.85020533
3viral transcription (GO:0019083)5.83486504
4translational termination (GO:0006415)5.65585365
5DNA deamination (GO:0045006)5.43610262
6maturation of SSU-rRNA (GO:0030490)4.85763053
7translational elongation (GO:0006414)4.84050234
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.83513433
9cotranslational protein targeting to membrane (GO:0006613)4.76180339
10behavioral response to nicotine (GO:0035095)4.72489663
11ribosomal large subunit biogenesis (GO:0042273)4.72202984
12protein targeting to ER (GO:0045047)4.71833533
13proteasome assembly (GO:0043248)4.69060892
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.66288300
15cellular protein complex disassembly (GO:0043624)4.62930655
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62920482
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.49761637
18protein localization to endoplasmic reticulum (GO:0070972)4.47560320
19DNA replication checkpoint (GO:0000076)4.43315912
20viral life cycle (GO:0019058)4.39379927
21ATP synthesis coupled proton transport (GO:0015986)4.36149278
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.36149278
23translational initiation (GO:0006413)4.33573121
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28614753
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.27773252
26CENP-A containing nucleosome assembly (GO:0034080)4.17866081
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.14740386
28NADH dehydrogenase complex assembly (GO:0010257)4.14740386
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14740386
30telomere maintenance via semi-conservative replication (GO:0032201)4.11271834
31chromatin remodeling at centromere (GO:0031055)4.06242554
32kinetochore assembly (GO:0051382)4.02607188
33translation (GO:0006412)4.01256902
34kinetochore organization (GO:0051383)3.97481592
35protein complex disassembly (GO:0043241)3.94058715
36respiratory electron transport chain (GO:0022904)3.88978851
37protein neddylation (GO:0045116)3.85281953
38protein complex biogenesis (GO:0070271)3.84415521
39ribonucleoprotein complex biogenesis (GO:0022613)3.82704217
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.78791421
41DNA strand elongation involved in DNA replication (GO:0006271)3.78502239
42electron transport chain (GO:0022900)3.78306569
43macromolecular complex disassembly (GO:0032984)3.76079326
44protoporphyrinogen IX biosynthetic process (GO:0006782)3.73701767
45telomere maintenance via recombination (GO:0000722)3.70894732
46termination of RNA polymerase III transcription (GO:0006386)3.67675770
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.67675770
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66452349
49regulation of mitochondrial translation (GO:0070129)3.64090604
50mitotic metaphase plate congression (GO:0007080)3.63555535
51DNA strand elongation (GO:0022616)3.59463617
52mitochondrial respiratory chain complex assembly (GO:0033108)3.58119648
53rRNA modification (GO:0000154)3.56188623
54cellular component biogenesis (GO:0044085)3.53032398
55response to pheromone (GO:0019236)3.52134673
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48555318
57rRNA processing (GO:0006364)3.47398330
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43677027
59protoporphyrinogen IX metabolic process (GO:0046501)3.43544013
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41058871
61spliceosomal snRNP assembly (GO:0000387)3.37807707
62mitotic recombination (GO:0006312)3.37695371
63heme biosynthetic process (GO:0006783)3.34836383
64DNA replication initiation (GO:0006270)3.33856888
65rRNA metabolic process (GO:0016072)3.33161390
66oxidative phosphorylation (GO:0006119)3.32877490
67platelet dense granule organization (GO:0060155)3.31192051
68chaperone-mediated protein transport (GO:0072321)3.31021314
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29339054
70negative regulation of ligase activity (GO:0051352)3.29339054
71spliceosomal complex assembly (GO:0000245)3.28122195
72metallo-sulfur cluster assembly (GO:0031163)3.27544907
73iron-sulfur cluster assembly (GO:0016226)3.27544907
74DNA replication-independent nucleosome organization (GO:0034724)3.24945502
75DNA replication-independent nucleosome assembly (GO:0006336)3.24945502
76nuclear-transcribed mRNA catabolic process (GO:0000956)3.22597994
77cytochrome complex assembly (GO:0017004)3.22293354
78deoxyribonucleotide biosynthetic process (GO:0009263)3.20156133
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19558034
80telomere maintenance via telomere lengthening (GO:0010833)3.18978591
81transcription-coupled nucleotide-excision repair (GO:0006283)3.17744881
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16186114
83regulation of cellular amino acid metabolic process (GO:0006521)3.15882884
84meiotic chromosome segregation (GO:0045132)3.14018005
85DNA ligation (GO:0006266)3.10924181
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10709426
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.10257892
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09423513
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09423513
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09254371
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09254371
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09254371
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09043137
94respiratory chain complex IV assembly (GO:0008535)3.08306549
95GTP biosynthetic process (GO:0006183)3.08286850
96protein-cofactor linkage (GO:0018065)3.08221493
97histone exchange (GO:0043486)3.08125765
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07921615
99metaphase plate congression (GO:0051310)3.07504896
100mRNA catabolic process (GO:0006402)3.07164761
1017-methylguanosine mRNA capping (GO:0006370)3.05318829
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04120118
103hydrogen ion transmembrane transport (GO:1902600)3.03412623
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02472009
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.02472009
106protein K6-linked ubiquitination (GO:0085020)3.01587232
107protein targeting to mitochondrion (GO:0006626)3.01493170
108centriole replication (GO:0007099)3.00956141
109signal transduction involved in cell cycle checkpoint (GO:0072395)3.00709184
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00419453
111RNA capping (GO:0036260)2.99977180
1127-methylguanosine RNA capping (GO:0009452)2.99977180
113cellular ketone body metabolic process (GO:0046950)2.99049537
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97569549
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97569549
116replication fork processing (GO:0031297)2.95106843
117kynurenine metabolic process (GO:0070189)2.94589297
118intracellular protein transmembrane import (GO:0044743)2.94431966
119pseudouridine synthesis (GO:0001522)2.92445968
120proton transport (GO:0015992)2.85219080
121indolalkylamine metabolic process (GO:0006586)2.85186165
122tryptophan catabolic process (GO:0006569)2.83187672
123indole-containing compound catabolic process (GO:0042436)2.83187672
124indolalkylamine catabolic process (GO:0046218)2.83187672
125recombinational repair (GO:0000725)2.83001788
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79514601
127double-strand break repair via homologous recombination (GO:0000724)2.79325455
128ATP biosynthetic process (GO:0006754)2.79030014
129hydrogen transport (GO:0006818)2.78269857
130signal peptide processing (GO:0006465)2.77196830
131water-soluble vitamin biosynthetic process (GO:0042364)2.76916601
132ketone body metabolic process (GO:1902224)2.76111068
133DNA double-strand break processing (GO:0000729)2.73071543
134piRNA metabolic process (GO:0034587)2.73064748
135male meiosis I (GO:0007141)2.71539937
136synapsis (GO:0007129)2.71115691
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.67848796
138reciprocal DNA recombination (GO:0035825)2.61990089
139reciprocal meiotic recombination (GO:0007131)2.61990089
140resolution of meiotic recombination intermediates (GO:0000712)2.60776069
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59489497
142regulation of mitotic spindle checkpoint (GO:1903504)2.59489497
143purine nucleoside triphosphate biosynthetic process (GO:0009145)2.59000533
144purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.57140255
145dopamine transport (GO:0015872)2.55950164
146organelle disassembly (GO:1903008)2.54480276
147nonmotile primary cilium assembly (GO:0035058)2.53235863
148regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53005256
149fucose catabolic process (GO:0019317)2.52824195
150L-fucose metabolic process (GO:0042354)2.52824195
151L-fucose catabolic process (GO:0042355)2.52824195
152ubiquinone biosynthetic process (GO:0006744)2.51634482
153indole-containing compound metabolic process (GO:0042430)2.49985684
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49964400
155serotonin metabolic process (GO:0042428)2.49055338
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.48672285
157microtubule depolymerization (GO:0007019)2.47776506
158cullin deneddylation (GO:0010388)2.47268283
159tryptophan metabolic process (GO:0006568)2.47119401
160mannosylation (GO:0097502)2.46155339
161epithelial cilium movement (GO:0003351)2.46108128
162meiosis I (GO:0007127)2.45894007
163inner mitochondrial membrane organization (GO:0007007)2.44809781
164rRNA methylation (GO:0031167)2.44279741
165preassembly of GPI anchor in ER membrane (GO:0016254)2.43750549
166peptidyl-histidine modification (GO:0018202)2.41311138
167tRNA processing (GO:0008033)2.40722732
168neuronal action potential (GO:0019228)2.40625743
169primary amino compound metabolic process (GO:1901160)2.38723692
170maturation of 5.8S rRNA (GO:0000460)2.37858839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.54264567
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63863058
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.19089396
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83159475
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.76646283
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.71794033
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58426437
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57866083
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.49697195
10ZNF274_21170338_ChIP-Seq_K562_Hela3.46525777
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.39181902
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36966010
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34167134
14* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31667679
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29211427
16VDR_22108803_ChIP-Seq_LS180_Human3.29120728
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97987161
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95662821
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81653408
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74559644
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73073944
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72911355
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68825763
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66189146
25EZH2_22144423_ChIP-Seq_EOC_Human2.63329269
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56894005
27VDR_23849224_ChIP-Seq_CD4+_Human2.52258201
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50725255
29XRN2_22483619_ChIP-Seq_HELA_Human2.43144119
30DCP1A_22483619_ChIP-Seq_HELA_Human2.38599243
31EWS_26573619_Chip-Seq_HEK293_Human2.36066463
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.31789104
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27766484
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27082639
35FUS_26573619_Chip-Seq_HEK293_Human2.21530300
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19341382
37GBX2_23144817_ChIP-Seq_PC3_Human2.18997371
38THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18819859
39POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16706027
40ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16221974
41FOXP3_21729870_ChIP-Seq_TREG_Human2.13225478
42TTF2_22483619_ChIP-Seq_HELA_Human2.06173279
43ELK1_19687146_ChIP-ChIP_HELA_Human1.98462359
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.98443812
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97825578
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97171186
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96500173
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95254240
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.93260477
50TAF15_26573619_Chip-Seq_HEK293_Human1.92183711
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86803796
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82776539
53IGF1R_20145208_ChIP-Seq_DFB_Human1.82628453
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80262047
55P300_19829295_ChIP-Seq_ESCs_Human1.79873257
56GABP_19822575_ChIP-Seq_HepG2_Human1.79337842
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79184194
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77053324
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76960756
60ER_23166858_ChIP-Seq_MCF-7_Human1.69634401
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66235153
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65672646
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64653966
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64063481
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63837991
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.59471935
67TP53_22573176_ChIP-Seq_HFKS_Human1.58724368
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57286438
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54968414
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54507523
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.48417444
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46863797
73MYC_18940864_ChIP-ChIP_HL60_Human1.43914536
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43760289
75AR_21909140_ChIP-Seq_LNCAP_Human1.43026120
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42407352
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42079212
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38398083
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36361215
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.35395006
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31810314
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31653237
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.31350869
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29093390
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.29091690
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28932421
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28447001
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.25818597
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25818597
90SOX2_19829295_ChIP-Seq_ESCs_Human1.24564629
91NANOG_19829295_ChIP-Seq_ESCs_Human1.24564629
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24033046
93BCAT_22108803_ChIP-Seq_LS180_Human1.23510590
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22559075
95AR_25329375_ChIP-Seq_VCAP_Human1.20628498
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20052548
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19075597
98RNF2_27304074_Chip-Seq_NSC_Mouse1.17786771
99CBP_20019798_ChIP-Seq_JUKART_Human1.16938564
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16938564
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16905149
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.16445155
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15265379
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14203541
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13543243
106HTT_18923047_ChIP-ChIP_STHdh_Human1.12624483
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12153124
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11629588
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08714702
110AR_20517297_ChIP-Seq_VCAP_Human1.08298602
111SMAD4_21799915_ChIP-Seq_A2780_Human1.08149963
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08045785
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07865730
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07771141
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07686092
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.07643058
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07184615
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.06349161
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05864007
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05864007
121CIITA_25753668_ChIP-Seq_RAJI_Human1.04455832
122STAT3_23295773_ChIP-Seq_U87_Human1.04371186
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.04339284
124TCF4_22108803_ChIP-Seq_LS180_Human1.03190254
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03049379
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.02820932
127NCOR_22424771_ChIP-Seq_293T_Human1.02126690
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01252006
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00509127
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00323728
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99854864
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99055594
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97542746
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97422061
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97191914
136REST_21632747_ChIP-Seq_MESCs_Mouse0.96145532
137TCF4_23295773_ChIP-Seq_U87_Human0.95696365
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.95529672
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95412123
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95112286
141HOXB7_26014856_ChIP-Seq_BT474_Human0.94220173
142IRF1_19129219_ChIP-ChIP_H3396_Human0.93255269
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93131040
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.92595537
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92435784
146RUNX2_22187159_ChIP-Seq_PCA_Human0.91758117
147KDM5A_27292631_Chip-Seq_BREAST_Human0.91585261
148TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88982445
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88413466
150* SPI1_23547873_ChIP-Seq_NB4_Human0.88009037
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87960709
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87945570
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82893358
154STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82885569
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82669221
156EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80445359
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80429550
158SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79707675
159GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76178191
160STAT1_20625510_ChIP-Seq_HELA_Human0.75763317
161KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74293899
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74277294
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74030012
164SOX17_20123909_ChIP-Seq_XEN_Mouse0.73304125
165KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72459593
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71508585
167FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70370592
168SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68823032
169KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68765008
170IRF8_22096565_ChIP-ChIP_GC-B_Human0.68219619
171DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67850718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.87507029
2MP0009379_abnormal_foot_pigmentation4.85259897
3MP0008057_abnormal_DNA_replication3.55413473
4MP0003111_abnormal_nucleus_morphology3.50350210
5MP0010094_abnormal_chromosome_stability3.49545011
6MP0004957_abnormal_blastocyst_morpholog3.21903994
7MP0003077_abnormal_cell_cycle2.95303215
8MP0008058_abnormal_DNA_repair2.70680280
9MP0008932_abnormal_embryonic_tissue2.65156385
10MP0000566_synostosis2.58382347
11MP0002163_abnormal_gland_morphology2.35333385
12MP0002837_dystrophic_cardiac_calcinosis2.28254807
13MP0003718_maternal_effect2.23927503
14MP0002736_abnormal_nociception_after2.12963285
15MP0001968_abnormal_touch/_nociception2.11272573
16MP0000569_abnormal_digit_pigmentation2.03656634
17MP0006036_abnormal_mitochondrial_physio2.03593722
18MP0003646_muscle_fatigue2.03388974
19MP0003195_calcinosis2.02054119
20MP0005551_abnormal_eye_electrophysiolog2.01070832
21MP0009046_muscle_twitch2.00072118
22MP0001986_abnormal_taste_sensitivity1.97430040
23MP0006292_abnormal_olfactory_placode1.94753997
24MP0003941_abnormal_skin_development1.90960710
25MP0006072_abnormal_retinal_apoptosis1.89491063
26MP0003186_abnormal_redox_activity1.89448756
27MP0008007_abnormal_cellular_replicative1.88290173
28MP0003880_abnormal_central_pattern1.86442264
29MP0009745_abnormal_behavioral_response1.85632231
30MP0003786_premature_aging1.77050744
31MP0000490_abnormal_crypts_of1.76075141
32MP0002102_abnormal_ear_morphology1.73832325
33MP0001485_abnormal_pinna_reflex1.67936925
34MP0002638_abnormal_pupillary_reflex1.66636703
35MP0009697_abnormal_copulation1.66480232
36MP0008872_abnormal_physiological_respon1.63782437
37MP0003136_yellow_coat_color1.61840936
38MP0005253_abnormal_eye_physiology1.57810221
39MP0002396_abnormal_hematopoietic_system1.56781978
40MP0002272_abnormal_nervous_system1.53572397
41MP0009333_abnormal_splenocyte_physiolog1.50067076
42MP0003011_delayed_dark_adaptation1.48923437
43MP0005646_abnormal_pituitary_gland1.47277879
44MP0001188_hyperpigmentation1.47276667
45MP0000631_abnormal_neuroendocrine_gland1.47166103
46MP0008875_abnormal_xenobiotic_pharmacok1.46876205
47MP0002653_abnormal_ependyma_morphology1.45473790
48MP0002234_abnormal_pharynx_morphology1.43961174
49MP0001835_abnormal_antigen_presentation1.40426302
50MP0002132_abnormal_respiratory_system1.39336879
51MP0002277_abnormal_respiratory_mucosa1.37519592
52MP0002148_abnormal_hypersensitivity_rea1.36059826
53MP0002160_abnormal_reproductive_system1.35545396
54MP0006276_abnormal_autonomic_nervous1.34635560
55MP0002735_abnormal_chemical_nociception1.33650891
56MP0004133_heterotaxia1.31421962
57MP0005645_abnormal_hypothalamus_physiol1.30700152
58MP0008877_abnormal_DNA_methylation1.30643670
59MP0000427_abnormal_hair_cycle1.28480349
60MP0004885_abnormal_endolymph1.28156122
61MP0002064_seizures1.27469741
62MP0001486_abnormal_startle_reflex1.27334879
63MP0010030_abnormal_orbit_morphology1.25971755
64MP0001984_abnormal_olfaction1.24484204
65MP0001905_abnormal_dopamine_level1.24091724
66MP0005379_endocrine/exocrine_gland_phen1.22615347
67MP0003763_abnormal_thymus_physiology1.20698480
68MP0005389_reproductive_system_phenotype1.19191636
69MP0004742_abnormal_vestibular_system1.19135189
70MP0003890_abnormal_embryonic-extraembry1.18680606
71MP0002876_abnormal_thyroid_physiology1.17074285
72MP0002095_abnormal_skin_pigmentation1.16246168
73MP0003123_paternal_imprinting1.15683368
74MP0004145_abnormal_muscle_electrophysio1.12344201
75MP0002572_abnormal_emotion/affect_behav1.12269301
76MP0004043_abnormal_pH_regulation1.12113983
77MP0009785_altered_susceptibility_to1.11866263
78MP0002067_abnormal_sensory_capabilities1.11292334
79MP0003787_abnormal_imprinting1.11065623
80MP0005451_abnormal_body_composition1.10801620
81MP0000313_abnormal_cell_death1.09988012
82MP0001970_abnormal_pain_threshold1.09041776
83MP0005410_abnormal_fertilization1.08939597
84MP0002733_abnormal_thermal_nociception1.08857256
85MP0003315_abnormal_perineum_morphology1.08007778
86MP0008995_early_reproductive_senescence1.07758656
87MP0006035_abnormal_mitochondrial_morpho1.06996000
88MP0001919_abnormal_reproductive_system1.06791834
89MP0000350_abnormal_cell_proliferation1.06695121
90MP0002928_abnormal_bile_duct1.06160882
91MP0001346_abnormal_lacrimal_gland1.05716146
92MP0000015_abnormal_ear_pigmentation1.05037468
93MP0001293_anophthalmia1.04235383
94MP0001501_abnormal_sleep_pattern1.04094184
95MP0003806_abnormal_nucleotide_metabolis1.03460994
96MP0002557_abnormal_social/conspecific_i1.03062348
97MP0004381_abnormal_hair_follicle1.02598536
98MP0002019_abnormal_tumor_incidence1.02175778
99MP0001529_abnormal_vocalization1.01685545
100MP0004147_increased_porphyrin_level1.00654516
101MP0000372_irregular_coat_pigmentation0.98907072
102MP0002210_abnormal_sex_determination0.97405139
103MP0003698_abnormal_male_reproductive0.96755208
104MP0002138_abnormal_hepatobiliary_system0.96724776
105MP0004215_abnormal_myocardial_fiber0.96688019
106MP0000749_muscle_degeneration0.95536160
107MP0005330_cardiomyopathy0.95226237
108MP0005075_abnormal_melanosome_morpholog0.94829365
109MP0005195_abnormal_posterior_eye0.94797738
110MP0000685_abnormal_immune_system0.93491403
111MP0005174_abnormal_tail_pigmentation0.92430996
112MP0003828_pulmonary_edema0.92107701
113MP0005671_abnormal_response_to0.91679098
114MP0000778_abnormal_nervous_system0.91365540
115MP0000026_abnormal_inner_ear0.90985200
116MP0002398_abnormal_bone_marrow0.90293519
117MP0002722_abnormal_immune_system0.90121580
118MP0000858_altered_metastatic_potential0.89260697
119MP0005423_abnormal_somatic_nervous0.88839594
120MP0008789_abnormal_olfactory_epithelium0.88588937
121MP0010386_abnormal_urinary_bladder0.88313791
122MP0003656_abnormal_erythrocyte_physiolo0.88160698
123MP0005386_behavior/neurological_phenoty0.86862011
124MP0004924_abnormal_behavior0.86862011
125MP0003567_abnormal_fetal_cardiomyocyte0.86825881
126MP0002734_abnormal_mechanical_nocicepti0.86193578
127MP0000689_abnormal_spleen_morphology0.86177933
128MP0002751_abnormal_autonomic_nervous0.85897108
129MP0002009_preneoplasia0.84311762
130MP0001119_abnormal_female_reproductive0.84018010
131MP0002752_abnormal_somatic_nervous0.83122245
132MP0004084_abnormal_cardiac_muscle0.82989018
133MP0002429_abnormal_blood_cell0.82538964
134MP0000647_abnormal_sebaceous_gland0.82481682
135MP0000703_abnormal_thymus_morphology0.81854011
136MP0003724_increased_susceptibility_to0.81801491
137MP0000716_abnormal_immune_system0.80482590
138MP0000049_abnormal_middle_ear0.80226064
139MP0002249_abnormal_larynx_morphology0.77801522
140MP0001800_abnormal_humoral_immune0.75358209
141MP0005084_abnormal_gallbladder_morpholo0.74993978
142MP0001145_abnormal_male_reproductive0.74860184
143MP0004142_abnormal_muscle_tone0.74328619
144MP0003137_abnormal_impulse_conducting0.74186824
145MP0001764_abnormal_homeostasis0.73703040
146MP0001819_abnormal_immune_cell0.73645980
147MP0005025_abnormal_response_to0.73619167
148MP0001853_heart_inflammation0.72475126
149MP0002127_abnormal_cardiovascular_syste0.72289340
150MP0002420_abnormal_adaptive_immunity0.71861502
151MP0001730_embryonic_growth_arrest0.71480992
152MP0005171_absent_coat_pigmentation0.70952655
153MP0001790_abnormal_immune_system0.70753741
154MP0005387_immune_system_phenotype0.70753741
155MP0008775_abnormal_heart_ventricle0.70536655
156MP0000613_abnormal_salivary_gland0.70116603
157MP0002452_abnormal_antigen_presenting0.69339834
158MP0001929_abnormal_gametogenesis0.69067334
159MP0002723_abnormal_immune_serum0.68262607
160MP0000653_abnormal_sex_gland0.67896131
161MP0005266_abnormal_metabolism0.67160707
162MP0002938_white_spotting0.67123510
163MP0005397_hematopoietic_system_phenotyp0.66330105

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.36788528
2Mitochondrial inheritance (HP:0001427)5.14120782
3Reticulocytopenia (HP:0001896)5.09317076
4Hepatocellular necrosis (HP:0001404)4.94541303
5Abnormal mitochondria in muscle tissue (HP:0008316)4.88625171
6Hepatic necrosis (HP:0002605)4.56963529
7Increased CSF lactate (HP:0002490)4.46056896
8Progressive macrocephaly (HP:0004481)4.43038913
9Acute encephalopathy (HP:0006846)4.41720090
10Abnormality of cells of the erythroid lineage (HP:0012130)4.41359675
11Abnormal number of erythroid precursors (HP:0012131)4.36658744
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.07261255
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.07261255
14Increased hepatocellular lipid droplets (HP:0006565)3.93010094
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.76101836
16Molar tooth sign on MRI (HP:0002419)3.71250381
17Abnormality of midbrain morphology (HP:0002418)3.71250381
18Exertional dyspnea (HP:0002875)3.68597995
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.63452133
20Lipid accumulation in hepatocytes (HP:0006561)3.57920447
21Pancreatic fibrosis (HP:0100732)3.51925090
223-Methylglutaconic aciduria (HP:0003535)3.49412486
23Increased serum lactate (HP:0002151)3.44929432
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42808825
25Macrocytic anemia (HP:0001972)3.40336851
26True hermaphroditism (HP:0010459)3.36285878
27Exercise intolerance (HP:0003546)3.32716003
28Chromsome breakage (HP:0040012)3.32102084
29Respiratory failure (HP:0002878)3.25461234
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.23126753
31Abnormality of alanine metabolism (HP:0010916)3.23126753
32Hyperalaninemia (HP:0003348)3.23126753
33Increased intramyocellular lipid droplets (HP:0012240)3.20806627
34Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20442636
35Pallor (HP:0000980)3.19822405
36Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17253844
37Cerebral edema (HP:0002181)3.16778843
38Congenital stationary night blindness (HP:0007642)3.15104355
39Lactic acidosis (HP:0003128)3.14755895
40Birth length less than 3rd percentile (HP:0003561)3.10022042
41Renal Fanconi syndrome (HP:0001994)3.09006852
42Nephronophthisis (HP:0000090)3.08463783
43Increased muscle lipid content (HP:0009058)2.79386948
44Breast hypoplasia (HP:0003187)2.78244580
45Microvesicular hepatic steatosis (HP:0001414)2.73763678
46Meckel diverticulum (HP:0002245)2.65475406
47Abnormality of the renal medulla (HP:0100957)2.63412088
48Cerebral palsy (HP:0100021)2.61335015
49Abnormality of the renal cortex (HP:0011035)2.60205060
50Secondary amenorrhea (HP:0000869)2.57236582
51Medial flaring of the eyebrow (HP:0010747)2.56764545
52Abnormality of glycolysis (HP:0004366)2.56612979
53Increased serum pyruvate (HP:0003542)2.56612979
54Optic disc pallor (HP:0000543)2.55115482
55Abnormality of the ileum (HP:0001549)2.54718149
56Abnormality of the preputium (HP:0100587)2.53100385
57Respiratory difficulties (HP:0002880)2.44147080
58Leukodystrophy (HP:0002415)2.40942806
59Patellar aplasia (HP:0006443)2.36860613
60Sclerocornea (HP:0000647)2.35828747
61Paralysis (HP:0003470)2.29391672
62Oral leukoplakia (HP:0002745)2.28650139
63Abnormal hemoglobin (HP:0011902)2.27994889
64Aplasia/Hypoplasia of the patella (HP:0006498)2.27541556
65Triphalangeal thumb (HP:0001199)2.25970694
66Attenuation of retinal blood vessels (HP:0007843)2.25750997
67Large for gestational age (HP:0001520)2.21543562
68Absent thumb (HP:0009777)2.19185183
69Type II lissencephaly (HP:0007260)2.17262603
70Chronic hepatic failure (HP:0100626)2.14154226
71Cleft eyelid (HP:0000625)2.13658795
72CNS demyelination (HP:0007305)2.13043561
73Cystic liver disease (HP:0006706)2.11946798
74Abnormal drinking behavior (HP:0030082)2.10979982
75Polydipsia (HP:0001959)2.10979982
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.10306031
77Furrowed tongue (HP:0000221)2.08554002
78Hypothermia (HP:0002045)2.06113650
79Male pseudohermaphroditism (HP:0000037)2.04813969
80Pendular nystagmus (HP:0012043)2.04706454
81Type I transferrin isoform profile (HP:0003642)2.03825792
82Abnormality of chromosome stability (HP:0003220)2.03482789
83Oligodactyly (hands) (HP:0001180)2.01687030
84Duplicated collecting system (HP:0000081)2.01612860
85Tubular atrophy (HP:0000092)2.01440727
86Abnormality of the labia minora (HP:0012880)2.01338068
87Cerebral hypomyelination (HP:0006808)1.98413515
88Methylmalonic acidemia (HP:0002912)1.97337017
89Pancytopenia (HP:0001876)1.96661558
90Rough bone trabeculation (HP:0100670)1.95549986
91Nausea (HP:0002018)1.95089806
92Increased IgM level (HP:0003496)1.94634116
93Gait imbalance (HP:0002141)1.94367918
94Inability to walk (HP:0002540)1.93662844
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.92905075
96Amniotic constriction ring (HP:0009775)1.92662411
97Abnormality of placental membranes (HP:0011409)1.92662411
98Abnormality of the pons (HP:0007361)1.92330192
99Aplastic anemia (HP:0001915)1.92330050
100Renal cortical cysts (HP:0000803)1.92094935
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.90888065
102Emotional lability (HP:0000712)1.89389291
103Congenital primary aphakia (HP:0007707)1.89077737
104Horseshoe kidney (HP:0000085)1.88042528
105Gaze-evoked nystagmus (HP:0000640)1.87486774
106Congenital, generalized hypertrichosis (HP:0004540)1.87115581
107Hyperventilation (HP:0002883)1.87076045
108Abnormality of the renal collecting system (HP:0004742)1.87043533
109Anencephaly (HP:0002323)1.86400629
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85073157
111Optic nerve hypoplasia (HP:0000609)1.84601496
112Methylmalonic aciduria (HP:0012120)1.82797903
113Abnormality of renal resorption (HP:0011038)1.82553943
114Concave nail (HP:0001598)1.81529683
115Thrombocytosis (HP:0001894)1.81371201
116Carpal bone hypoplasia (HP:0001498)1.81069519
117Pulmonary fibrosis (HP:0002206)1.79847612
118Absent radius (HP:0003974)1.78922856
119Lethargy (HP:0001254)1.78866537
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78813877
121Abnormality of reticulocytes (HP:0004312)1.78458955
12211 pairs of ribs (HP:0000878)1.78394677
123Dynein arm defect of respiratory motile cilia (HP:0012255)1.78309182
124Absent/shortened dynein arms (HP:0200106)1.78309182
125Hypoplasia of the pons (HP:0012110)1.78287264
126Gliosis (HP:0002171)1.78248805
127Septo-optic dysplasia (HP:0100842)1.78074816
128Abnormality of urine glucose concentration (HP:0011016)1.76283085
129Glycosuria (HP:0003076)1.76283085
130Premature graying of hair (HP:0002216)1.75715085
131Hypopigmented skin patches (HP:0001053)1.75325181
132Progressive external ophthalmoplegia (HP:0000590)1.75180545
133Duodenal stenosis (HP:0100867)1.74692800
134Small intestinal stenosis (HP:0012848)1.74692800
135Abolished electroretinogram (ERG) (HP:0000550)1.74592515
136Generalized aminoaciduria (HP:0002909)1.73241800
137Nephrogenic diabetes insipidus (HP:0009806)1.72508825
138Bone marrow hypocellularity (HP:0005528)1.72449177
139Decreased central vision (HP:0007663)1.71208489
140Polyuria (HP:0000103)1.70963308
141Progressive inability to walk (HP:0002505)1.70932074
142Clubbing of toes (HP:0100760)1.66113096
143Pancreatic cysts (HP:0001737)1.65110225
144Muscle fiber atrophy (HP:0100295)1.63937563
145Microretrognathia (HP:0000308)1.63415582
146Hypoplasia of the radius (HP:0002984)1.62815068
147Absent forearm bone (HP:0003953)1.62457335
148Aplasia involving forearm bones (HP:0009822)1.62457335
149Sparse eyelashes (HP:0000653)1.62198137
150Cutaneous photosensitivity (HP:0000992)1.61879183
151Myelodysplasia (HP:0002863)1.61284065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.86525638
2STK164.20581130
3TLK14.18279959
4FRK3.86490930
5NME23.84229653
6EIF2AK13.36635439
7SRPK13.27503914
8WEE13.08407449
9VRK12.60324127
10PNCK2.54462619
11INSRR2.41104184
12PBK2.38178532
13WNK32.05497868
14WNK42.04710596
15PLK41.99656730
16ZAK1.97395529
17PIM21.92750756
18VRK21.85638272
19PLK11.76652556
20TESK21.74399626
21GRK11.74353660
22CDC71.73562913
23TTK1.68297453
24MAP4K21.65456323
25NEK21.60994556
26MAPK131.55294217
27BRSK21.49874511
28STK391.48592111
29EIF2AK31.47677452
30AURKB1.46928473
31EIF2AK21.44939476
32TNIK1.41687489
33TAOK31.39875086
34OXSR11.37876702
35NME11.37838246
36ACVR1B1.34206023
37AURKA1.33008395
38MKNK21.32039035
39BCKDK1.30060234
40CDK81.24957648
41IRAK31.24499006
42STK41.22458159
43MAP3K121.20445492
44TGFBR11.17321876
45STK38L1.15680706
46MST41.15647088
47CHEK21.15098686
48PLK31.10820192
49MKNK11.04802216
50PIM11.04727744
51DYRK31.00122298
52ADRBK10.99821252
53STK240.96948021
54MYLK0.96379281
55TRIM280.96354011
56MAP3K110.95366782
57IRAK40.95248148
58MAPK150.94161227
59CDK70.93812315
60BMPR1B0.93391409
61BRSK10.93068635
62PRKCG0.91685209
63CAMKK20.91501841
64NEK10.90476243
65IKBKB0.88702504
66TSSK60.88623618
67PLK20.88027850
68ABL20.87623355
69MAP3K40.87518805
70ATR0.87173375
71KDR0.83819572
72NEK90.83577289
73MAP3K140.82120040
74NUAK10.80675430
75OBSCN0.78518757
76ILK0.77731993
77CCNB10.77240556
78CSNK2A10.76963703
79PAK30.75955601
80PDK20.74656000
81DAPK20.74431083
82RPS6KA40.74028338
83MARK10.70362399
84CASK0.68509496
85RPS6KA50.68100885
86TEC0.67808492
87TXK0.67802637
88TESK10.67483206
89TAF10.67426294
90LIMK10.67371594
91CLK10.67261823
92BRAF0.64213101
93YES10.63481647
94CDK40.61775914
95PRKCE0.61514077
96MUSK0.60286820
97TYK20.59487823
98PHKG20.58113017
99PHKG10.58113017
100MAPKAPK50.57939433
101STK30.56688844
102ADRBK20.56524846
103CSNK2A20.55933875
104CAMK2A0.55846942
105DAPK30.53174534
106PIK3CA0.52769875
107BCR0.51388522
108NTRK30.51114990
109PKN10.50240131
110CSNK1G20.48897325
111CSNK1G10.46816619
112RPS6KB20.46626707
113PAK10.45206333
114PASK0.44724229
115CSNK1G30.43187239
116PRKCQ0.43134886
117CHEK10.42682189
118PRKACA0.40854123
119ERBB30.40805617
120MAPKAPK30.40466683
121ATM0.39754898
122BMPR20.38319707
123DYRK20.38083448
124JAK30.37877920
125MAP3K80.37695433
126MAP4K10.37592294
127MINK10.37432250
128KIT0.36321939
129PTK2B0.36303192
130CDK190.35920987
131MAP2K60.35899317
132EPHA40.35889802
133PRKCI0.33645259
134LYN0.33195615
135TAOK20.32999753
136CDK30.31017871
137TBK10.30262436
138PINK10.30252470
139ARAF0.28687333
140FLT30.27365789
141PRKCD0.27345365
142IKBKE0.27054253
143BLK0.26291719
144MAP2K70.26159293
145CDK20.26128246
146CHUK0.25002464
147PRKD20.24173661
148LRRK20.23843638

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.37679266
2Proteasome_Homo sapiens_hsa030504.01214267
3DNA replication_Homo sapiens_hsa030303.75250566
4Oxidative phosphorylation_Homo sapiens_hsa001903.56097451
5RNA polymerase_Homo sapiens_hsa030203.37578899
6Parkinsons disease_Homo sapiens_hsa050123.29956204
7Mismatch repair_Homo sapiens_hsa034303.26762909
8Homologous recombination_Homo sapiens_hsa034403.04299500
9Huntingtons disease_Homo sapiens_hsa050162.57803731
10Pyrimidine metabolism_Homo sapiens_hsa002402.48485605
11Spliceosome_Homo sapiens_hsa030402.47451078
12Base excision repair_Homo sapiens_hsa034102.34277421
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28146921
14Nucleotide excision repair_Homo sapiens_hsa034202.27833928
15Fanconi anemia pathway_Homo sapiens_hsa034602.16031328
16Alzheimers disease_Homo sapiens_hsa050102.14709122
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04700447
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85589913
19One carbon pool by folate_Homo sapiens_hsa006701.83782237
20Butanoate metabolism_Homo sapiens_hsa006501.79239978
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78791636
22Phototransduction_Homo sapiens_hsa047441.77808021
23Cell cycle_Homo sapiens_hsa041101.74893552
24RNA transport_Homo sapiens_hsa030131.73966156
25Nitrogen metabolism_Homo sapiens_hsa009101.73628341
26Protein export_Homo sapiens_hsa030601.67190550
27Basal transcription factors_Homo sapiens_hsa030221.62922134
28Nicotine addiction_Homo sapiens_hsa050331.59416145
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.47933105
30Selenocompound metabolism_Homo sapiens_hsa004501.45532888
31RNA degradation_Homo sapiens_hsa030181.45371557
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40132031
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39942925
34Non-homologous end-joining_Homo sapiens_hsa034501.37854455
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37841343
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37463023
37Purine metabolism_Homo sapiens_hsa002301.37087383
38Cardiac muscle contraction_Homo sapiens_hsa042601.35112402
39Tryptophan metabolism_Homo sapiens_hsa003801.31503336
40Folate biosynthesis_Homo sapiens_hsa007901.15173522
41Allograft rejection_Homo sapiens_hsa053301.07786910
42p53 signaling pathway_Homo sapiens_hsa041151.06390805
43Sulfur relay system_Homo sapiens_hsa041221.05000513
44Systemic lupus erythematosus_Homo sapiens_hsa053221.04795321
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03003895
46Olfactory transduction_Homo sapiens_hsa047401.02077237
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01832633
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.01110476
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00210917
50Taste transduction_Homo sapiens_hsa047420.97394389
51Epstein-Barr virus infection_Homo sapiens_hsa051690.94873813
52Chemical carcinogenesis_Homo sapiens_hsa052040.90144982
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90057953
54Morphine addiction_Homo sapiens_hsa050320.89820043
55Collecting duct acid secretion_Homo sapiens_hsa049660.86638857
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83458395
57Caffeine metabolism_Homo sapiens_hsa002320.83442760
58Sulfur metabolism_Homo sapiens_hsa009200.81764080
59Ether lipid metabolism_Homo sapiens_hsa005650.79663637
60Vitamin B6 metabolism_Homo sapiens_hsa007500.79437381
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78731965
62Graft-versus-host disease_Homo sapiens_hsa053320.78045179
63Pentose phosphate pathway_Homo sapiens_hsa000300.77932153
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77506185
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76965393
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.76770778
67Autoimmune thyroid disease_Homo sapiens_hsa053200.76331966
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76284136
69Glutathione metabolism_Homo sapiens_hsa004800.75603122
70Herpes simplex infection_Homo sapiens_hsa051680.74416433
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.73497526
72Serotonergic synapse_Homo sapiens_hsa047260.70835387
73Arachidonic acid metabolism_Homo sapiens_hsa005900.69101825
74GABAergic synapse_Homo sapiens_hsa047270.68132989
75Regulation of autophagy_Homo sapiens_hsa041400.68065954
76Metabolic pathways_Homo sapiens_hsa011000.67944294
77Steroid biosynthesis_Homo sapiens_hsa001000.66959370
78mRNA surveillance pathway_Homo sapiens_hsa030150.66556161
79Primary immunodeficiency_Homo sapiens_hsa053400.65419109
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63356269
81Carbon metabolism_Homo sapiens_hsa012000.63270441
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58898472
83Circadian entrainment_Homo sapiens_hsa047130.56530016
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.55265848
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.52851444
86Fatty acid elongation_Homo sapiens_hsa000620.50790685
87Glutamatergic synapse_Homo sapiens_hsa047240.48780043
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48504379
89Propanoate metabolism_Homo sapiens_hsa006400.47097865
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45994068
91Measles_Homo sapiens_hsa051620.45522357
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43944228
93Ovarian steroidogenesis_Homo sapiens_hsa049130.41580422
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41399365
95Insulin secretion_Homo sapiens_hsa049110.41379578
96ABC transporters_Homo sapiens_hsa020100.40389445
97Pyruvate metabolism_Homo sapiens_hsa006200.39436358
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38914802
99Biosynthesis of amino acids_Homo sapiens_hsa012300.38142319
100Asthma_Homo sapiens_hsa053100.37949423
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37290159
102Calcium signaling pathway_Homo sapiens_hsa040200.37263481
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36622312
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.36524709
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36228248
106Antigen processing and presentation_Homo sapiens_hsa046120.35581711
107Mineral absorption_Homo sapiens_hsa049780.35256514
108Oocyte meiosis_Homo sapiens_hsa041140.33327505
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33111487
110Fatty acid degradation_Homo sapiens_hsa000710.31678977
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.31416927
112Viral carcinogenesis_Homo sapiens_hsa052030.31220037
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30980464
114Fat digestion and absorption_Homo sapiens_hsa049750.30097725
115Arginine and proline metabolism_Homo sapiens_hsa003300.28917472
116Linoleic acid metabolism_Homo sapiens_hsa005910.27298855
117Hematopoietic cell lineage_Homo sapiens_hsa046400.27272990
118Cocaine addiction_Homo sapiens_hsa050300.26895042
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26501442
120Peroxisome_Homo sapiens_hsa041460.25705253
121Apoptosis_Homo sapiens_hsa042100.24133903
122HTLV-I infection_Homo sapiens_hsa051660.22518131
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22194135
124Legionellosis_Homo sapiens_hsa051340.21712514
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20930739
126Type I diabetes mellitus_Homo sapiens_hsa049400.20538527
127Viral myocarditis_Homo sapiens_hsa054160.17485214
128Tyrosine metabolism_Homo sapiens_hsa003500.17351554
129Fructose and mannose metabolism_Homo sapiens_hsa000510.15663208
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15225109
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15149455
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15059215
133Alcoholism_Homo sapiens_hsa050340.14695372
134Galactose metabolism_Homo sapiens_hsa000520.13332741
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12653304
136Malaria_Homo sapiens_hsa051440.11841387
137Influenza A_Homo sapiens_hsa051640.11609768
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11336493
139Retinol metabolism_Homo sapiens_hsa008300.09633565
140Rheumatoid arthritis_Homo sapiens_hsa053230.07639550
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06563577
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.06283756
143beta-Alanine metabolism_Homo sapiens_hsa004100.05526206

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