CMPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact7.12340644
2modulation by symbiont of host immune response (GO:0052553)7.12340644
3positive regulation by symbiont of host defense response (GO:0052509)7.12340644
4modulation by symbiont of host defense response (GO:0052031)7.12340644
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.12340644
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.12340644
7positive regulation of interferon-alpha production (GO:0032727)6.55391222
8cellular response to interferon-alpha (GO:0035457)6.39732309
9type I interferon signaling pathway (GO:0060337)6.33164621
10cellular response to type I interferon (GO:0071357)6.33164621
11response to type I interferon (GO:0034340)6.25417442
12regulation of interferon-alpha production (GO:0032647)6.20598435
13response to interferon-alpha (GO:0035455)5.99679436
14response to peptidoglycan (GO:0032494)5.60704786
15negative regulation of viral genome replication (GO:0045071)5.40126103
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.26719971
17response to host immune response (GO:0052572)5.26719971
18cellular response to exogenous dsRNA (GO:0071360)5.03499103
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02608801
20macrophage activation involved in immune response (GO:0002281)4.81705286
21positive regulation of type 2 immune response (GO:0002830)4.79066665
22positive regulation of gamma-delta T cell activation (GO:0046645)4.71482763
23negative regulation of interleukin-12 production (GO:0032695)4.67398533
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66513508
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66513508
26response to host (GO:0075136)4.66433913
27response to host defenses (GO:0052200)4.66433913
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.66433913
29positive regulation of interferon-beta production (GO:0032728)4.65931841
30positive regulation of toll-like receptor signaling pathway (GO:0034123)4.63401370
31neutrophil activation involved in immune response (GO:0002283)4.61058575
32lipopolysaccharide-mediated signaling pathway (GO:0031663)4.51750379
33regulation of interferon-beta biosynthetic process (GO:0045357)4.49834262
34immunoglobulin mediated immune response (GO:0016064)4.49463871
35cellular response to interferon-beta (GO:0035458)4.47851025
36cellular response to virus (GO:0098586)4.46353567
37regulation of T-helper 1 cell differentiation (GO:0045625)4.41521453
38positive regulation of T cell cytokine production (GO:0002726)4.40470414
39microglial cell activation (GO:0001774)4.27326553
40antigen processing and presentation of endogenous antigen (GO:0019883)4.27212361
41positive regulation of chemokine biosynthetic process (GO:0045080)4.23188034
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.21799110
43positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.21650730
44T cell migration (GO:0072678)4.17047991
45interferon-gamma-mediated signaling pathway (GO:0060333)4.16968699
46positive regulation of cAMP-mediated signaling (GO:0043950)4.16643598
47lymphocyte chemotaxis (GO:0048247)4.15766605
48negative regulation of cell killing (GO:0031342)4.14025892
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14025892
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03065687
51response to interferon-beta (GO:0035456)4.01296940
52positive regulation of natural killer cell differentiation (GO:0032825)4.01224091
53natural killer cell mediated cytotoxicity (GO:0042267)3.91997617
54natural killer cell mediated immunity (GO:0002228)3.91997617
55regulation of RIG-I signaling pathway (GO:0039535)3.89460025
56hydrogen peroxide biosynthetic process (GO:0050665)3.79447926
57respiratory burst (GO:0045730)3.78182716
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.71052536
59regulation of vitamin D biosynthetic process (GO:0060556)3.69969412
60defense response to virus (GO:0051607)3.68919822
61regulation of chemokine biosynthetic process (GO:0045073)3.66484201
62granulocyte activation (GO:0036230)3.64434684
63regulation of chronic inflammatory response (GO:0002676)3.61577923
64regulation of interferon-gamma biosynthetic process (GO:0045072)3.59687026
65regulation of type I interferon-mediated signaling pathway (GO:0060338)3.51778677
66cellular response to interferon-gamma (GO:0071346)3.51772394
67negative regulation of cytokine production involved in immune response (GO:0002719)3.51500264
68detection of other organism (GO:0098543)3.50731493
69negative regulation of T cell mediated immunity (GO:0002710)3.48721552
70positive regulation of heat generation (GO:0031652)3.48151330
71myeloid cell activation involved in immune response (GO:0002275)3.45567534
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42028454
73defense response to protozoan (GO:0042832)3.41764035
74reactive oxygen species biosynthetic process (GO:1903409)3.35798885
75regulation of T cell cytokine production (GO:0002724)3.35455426
76regulation of fever generation (GO:0031620)3.35416213
77response to protozoan (GO:0001562)3.34302532
78regulation of interferon-beta production (GO:0032648)3.34045807
79response to muramyl dipeptide (GO:0032495)3.33649735
80germinal center formation (GO:0002467)3.33377606
81T-helper 1 type immune response (GO:0042088)3.33205686
82positive regulation of interleukin-12 production (GO:0032735)3.32572038
83B cell mediated immunity (GO:0019724)3.30927969
84regulation of mononuclear cell migration (GO:0071675)3.30319672
85regulation of gamma-delta T cell activation (GO:0046643)3.30061239
86macrophage activation (GO:0042116)3.29943799
87positive regulation of interleukin-17 production (GO:0032740)3.29681835
88detection of bacterium (GO:0016045)3.29349164
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28227897
90regulation of T cell tolerance induction (GO:0002664)3.28017332
91eosinophil chemotaxis (GO:0048245)3.25449179
92neutrophil activation (GO:0042119)3.24272992
93regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.24158252
94negative regulation of myeloid cell apoptotic process (GO:0033033)3.23819463
95regulation of interleukin-17 production (GO:0032660)3.21332503
96negative regulation of viral process (GO:0048525)3.20500522
97regulation of viral genome replication (GO:0045069)3.17355955
98response to interferon-gamma (GO:0034341)3.17183010
99I-kappaB phosphorylation (GO:0007252)3.16150746
100positive regulation of antigen processing and presentation (GO:0002579)3.15393343
101negative regulation of interleukin-17 production (GO:0032700)3.13877280
102positive regulation of lymphocyte migration (GO:2000403)3.13574694
103JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.12880147
104regulation of interleukin-12 production (GO:0032655)3.11682651
105NIK/NF-kappaB signaling (GO:0038061)3.10860677
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10265872
107superoxide anion generation (GO:0042554)3.08849349
108myeloid dendritic cell differentiation (GO:0043011)3.08383749
109monocyte chemotaxis (GO:0002548)3.07667000
110negative regulation of type 2 immune response (GO:0002829)3.06494911
111detection of molecule of bacterial origin (GO:0032490)3.05717202
112regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05376695
113positive regulation of defense response to virus by host (GO:0002230)3.04898532
114regulation of MHC class I biosynthetic process (GO:0045343)3.02946527
115detection of external biotic stimulus (GO:0098581)3.02804886
116positive regulation of cellular amide metabolic process (GO:0034250)3.02804281
117regulation of antigen processing and presentation (GO:0002577)3.02697192
118regulation of cytokine secretion involved in immune response (GO:0002739)2.99305134
119regulation of tolerance induction (GO:0002643)2.98893164
120response to exogenous dsRNA (GO:0043330)2.98730009
121regulation of vitamin metabolic process (GO:0030656)2.96586414
122negative regulation of type I interferon production (GO:0032480)2.96143288
123regulation of toll-like receptor signaling pathway (GO:0034121)2.94289641
124regulation of defense response to virus by host (GO:0050691)2.93623927
125natural killer cell activation involved in immune response (GO:0002323)2.92906551
126positive regulation of chemokine production (GO:0032722)2.90461654
127regulation of T-helper 2 cell differentiation (GO:0045628)2.89878972
128negative regulation of innate immune response (GO:0045824)2.88395227
129interferon-gamma secretion (GO:0072643)2.88378191
130leukocyte mediated cytotoxicity (GO:0001909)2.87510937
131regulation of T-helper cell differentiation (GO:0045622)2.86585059
132regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.86167269
133eosinophil migration (GO:0072677)2.85883043
134production of molecular mediator involved in inflammatory response (GO:0002532)2.85271932
135regulation of type 2 immune response (GO:0002828)2.83913896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.38857032
2IRF8_21731497_ChIP-ChIP_J774_Mouse8.08053429
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.66595798
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.69623264
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.72197260
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.51212155
7GATA1_22025678_ChIP-Seq_K562_Human3.93419412
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65259349
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58885354
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56587888
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17259609
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00769724
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86588875
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72274692
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60942800
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46284875
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39335803
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21514416
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21358412
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.01753892
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68804257
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68269817
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67537035
24SPI1_23547873_ChIP-Seq_NB4_Human1.55613864
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54118229
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49670911
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47492648
28CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44024442
29* PU_27001747_Chip-Seq_BMDM_Mouse1.42490373
30MYB_26560356_Chip-Seq_TH2_Human1.37184316
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.36144589
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34881842
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34269063
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32094747
35TCF7_22412390_ChIP-Seq_EML_Mouse1.27929826
36VDR_24787735_ChIP-Seq_THP-1_Human1.26317934
37MYC_22102868_ChIP-Seq_BL_Human1.25358803
38CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21953681
39KDM2B_26808549_Chip-Seq_DND41_Human1.20448520
40EGR1_19032775_ChIP-ChIP_M12_Human1.17291886
41SPI1_23127762_ChIP-Seq_K562_Human1.17279811
42* GATA3_26560356_Chip-Seq_TH2_Human1.15296018
43MAF_26560356_Chip-Seq_TH1_Human1.13631090
44VDR_24763502_ChIP-Seq_THP-1_Human1.13147688
45PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12974257
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.12872139
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12843138
48CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11900768
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11205345
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.09981820
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09321972
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07930277
53MYB_26560356_Chip-Seq_TH1_Human1.05387628
54RUNX_20019798_ChIP-Seq_JUKART_Human1.04791300
55SOX2_20726797_ChIP-Seq_SW620_Human1.04015765
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01594985
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01567314
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01003876
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00775951
60SCL_19346495_ChIP-Seq_HPC-7_Human0.98380547
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97476270
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97078654
63GATA3_27048872_Chip-Seq_THYMUS_Human0.96868769
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96737884
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94279599
66EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93190542
67* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92198474
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91024789
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90381335
70IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85919859
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84568315
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84302173
73NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84302173
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83296436
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82585691
76* GATA2_21666600_ChIP-Seq_HMVEC_Human0.80838442
77LXR_22292898_ChIP-Seq_THP-1_Human0.79765416
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78988629
79STAT1_20625510_ChIP-Seq_HELA_Human0.75297930
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74917667
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74865640
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.73665659
83NCOR1_26117541_ChIP-Seq_K562_Human0.72761134
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.72486344
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71500099
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69520881
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69199739
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69043782
89BCL6_27268052_Chip-Seq_Bcells_Human0.68421652
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67424390
91RXR_22158963_ChIP-Seq_LIVER_Mouse0.66211917
92TFEB_21752829_ChIP-Seq_HELA_Human0.65773246
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.65281071
94GATA1_19941827_ChIP-Seq_MEL86_Mouse0.65002652
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64419253
96BCOR_27268052_Chip-Seq_Bcells_Human0.64412562
97SMRT_27268052_Chip-Seq_Bcells_Human0.64290615
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64246992
99UTX_26944678_Chip-Seq_JUKART_Human0.63864494
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63794063
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.62807166
102* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62540305
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.59799497
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.58906236
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.57615341
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55386476
107MAF_26560356_Chip-Seq_TH2_Human0.54751841
108CJUN_26792858_Chip-Seq_BT549_Human0.52756944
109* GATA2_19941826_ChIP-Seq_K562_Human0.52625860
110* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.52495980
111VDR_21846776_ChIP-Seq_THP-1_Human0.50437202
112* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50017470
113* GATA1_19941826_ChIP-Seq_K562_Human0.49760067
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.49065929
115* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.48648509
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.46835297
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.46403764
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.44701401
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.44247550
120CTCF_26484167_Chip-Seq_Bcells_Mouse0.43674662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.58376264
2MP0001835_abnormal_antigen_presentation4.33530658
3MP0006082_CNS_inflammation4.02830838
4MP0003724_increased_susceptibility_to4.00004333
5MP0003303_peritoneal_inflammation3.80028408
6MP0002148_abnormal_hypersensitivity_rea3.70511390
7MP0003436_decreased_susceptibility_to3.65597895
8MP0004510_myositis3.29193854
9MP0005000_abnormal_immune_tolerance3.27348864
10MP0005025_abnormal_response_to3.22690696
11MP0001790_abnormal_immune_system3.12395489
12MP0005387_immune_system_phenotype3.12395489
13MP0002419_abnormal_innate_immunity2.98840075
14MP0000685_abnormal_immune_system2.84049290
15MP0005671_abnormal_response_to2.54039489
16MP0002723_abnormal_immune_serum2.53132096
17MP0002452_abnormal_antigen_presenting2.52374849
18MP0001800_abnormal_humoral_immune2.51232119
19MP0004858_abnormal_nervous_system2.42635862
20MP0005058_abnormal_lysosome_morphology2.40313307
21MP0001533_abnormal_skeleton_physiology2.37198275
22MP0009764_decreased_sensitivity_to2.23443175
23MP0004947_skin_inflammation2.21882531
24MP0001819_abnormal_immune_cell2.09588174
25MP0003075_altered_response_to2.03082615
26MP0000604_amyloidosis2.02704778
27MP0002420_abnormal_adaptive_immunity2.00934779
28MP0005451_abnormal_body_composition2.00526684
29MP0008469_abnormal_protein_level1.94714986
30MP0003172_abnormal_lysosome_physiology1.87785668
31MP0005464_abnormal_platelet_physiology1.85615135
32MP0001845_abnormal_inflammatory_respons1.84725585
33MP0001853_heart_inflammation1.82553428
34MP0003448_altered_tumor_morphology1.82347656
35MP0009278_abnormal_bone_marrow1.75247465
36MP0000343_altered_response_to1.74806146
37MP0010155_abnormal_intestine_physiology1.63855882
38MP0005167_abnormal_blood-brain_barrier1.61139852
39MP0002006_tumorigenesis1.60186406
40MP0009840_abnormal_foam_cell1.51628935
41MP0008004_abnormal_stomach_pH1.49547192
42MP0000716_abnormal_immune_system1.45011395
43MP0005164_abnormal_response_to1.44571838
44MP0002405_respiratory_system_inflammati1.42134806
45MP0005397_hematopoietic_system_phenotyp1.40336695
46MP0001545_abnormal_hematopoietic_system1.40336695
47MP0004782_abnormal_surfactant_physiolog1.40069361
48MP0005310_abnormal_salivary_gland1.37493541
49MP0002998_abnormal_bone_remodeling1.37181717
50MP0005166_decreased_susceptibility_to1.34656048
51MP0003191_abnormal_cellular_cholesterol1.34620209
52MP0002398_abnormal_bone_marrow1.33475520
53MP0010307_abnormal_tumor_latency1.28415409
54MP0002139_abnormal_hepatobiliary_system1.27554396
55MP0001501_abnormal_sleep_pattern1.26493107
56MP0009333_abnormal_splenocyte_physiolog1.26207588
57MP0002277_abnormal_respiratory_mucosa1.25822778
58MP0003690_abnormal_glial_cell1.22992318
59MP0006054_spinal_hemorrhage1.14372981
60MP0003186_abnormal_redox_activity1.12488716
61MP0002429_abnormal_blood_cell1.11769710
62MP0002166_altered_tumor_susceptibility1.10787670
63MP0000858_altered_metastatic_potential1.09874990
64MP0000465_gastrointestinal_hemorrhage1.09066782
65MP0009763_increased_sensitivity_to1.08153952
66MP0003300_gastrointestinal_ulcer1.07291248
67MP0003329_amyloid_beta_deposits1.02889406
68MP0005390_skeleton_phenotype1.00900572
69MP0003195_calcinosis1.00003395
70MP0003806_abnormal_nucleotide_metabolis0.99809455
71MP0000689_abnormal_spleen_morphology0.98296818
72MP0003183_abnormal_peptide_metabolism0.96662809
73MP0002332_abnormal_exercise_endurance0.92398289
74MP0002138_abnormal_hepatobiliary_system0.89329809
75MP0002722_abnormal_immune_system0.87596636
76MP0003866_abnormal_defecation0.85452105
77MP0001542_abnormal_bone_strength0.81348666
78MP0000703_abnormal_thymus_morphology0.81112599
79MP0003091_abnormal_cell_migration0.77203433
80MP0005083_abnormal_biliary_tract0.76565092
81MP0003656_abnormal_erythrocyte_physiolo0.75974656
82MP0008260_abnormal_autophagy0.75285495
83MP0001663_abnormal_digestive_system0.75069709
84MP0003646_muscle_fatigue0.73436127
85MP0001851_eye_inflammation0.72354960
86MP0008874_decreased_physiological_sensi0.72017245
87MP0002132_abnormal_respiratory_system0.71506581
88MP0003221_abnormal_cardiomyocyte_apopto0.67613265
89MP0003045_fibrosis0.67269908
90MP0001873_stomach_inflammation0.65597033
91MP0000249_abnormal_blood_vessel0.65078629
92MP0010386_abnormal_urinary_bladder0.64487448
93MP0001881_abnormal_mammary_gland0.62557216
94MP0002693_abnormal_pancreas_physiology0.62300640
95MP0005165_increased_susceptibility_to0.60400896
96MP0002933_joint_inflammation0.60384010
97MP0003453_abnormal_keratinocyte_physiol0.58975463
98MP0005319_abnormal_enzyme/_coenzyme0.58891044
99MP0003763_abnormal_thymus_physiology0.57606441
100MP0005535_abnormal_body_temperature0.57318688
101MP0002136_abnormal_kidney_physiology0.56137249
102MP0008775_abnormal_heart_ventricle0.56057416
103MP0002254_reproductive_system_inflammat0.56050376
104MP0000609_abnormal_liver_physiology0.54974674
105MP0005584_abnormal_enzyme/coenzyme_acti0.51812305
106MP0000569_abnormal_digit_pigmentation0.51434467
107MP0002090_abnormal_vision0.49781993
108MP0004808_abnormal_hematopoietic_stem0.49588366
109MP0003795_abnormal_bone_structure0.49081721
110MP0005076_abnormal_cell_differentiation0.48873255
111MP0009765_abnormal_xenobiotic_induced0.48535756
112MP0004883_abnormal_blood_vessel0.46788206
113MP0001958_emphysema0.46273094
114MP0000920_abnormal_myelination0.45797018
115MP0005023_abnormal_wound_healing0.45485075
116MP0003828_pulmonary_edema0.45245701
117MP0010352_gastrointestinal_tract_polyps0.44368598

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.68315791
2Eczematoid dermatitis (HP:0000976)6.53892367
3Recurrent bacterial skin infections (HP:0005406)6.41478478
4Autoimmune thrombocytopenia (HP:0001973)6.07421293
5Recurrent gram-negative bacterial infections (HP:0005420)5.60127955
6Increased IgM level (HP:0003496)5.35174023
7Elevated erythrocyte sedimentation rate (HP:0003565)5.17940345
8Abnormality of macrophages (HP:0004311)5.09151641
9Mediastinal lymphadenopathy (HP:0100721)5.05098313
10Basal ganglia calcification (HP:0002135)4.46143172
11Chronic otitis media (HP:0000389)4.39780747
12Stomatitis (HP:0010280)4.21486098
13Systemic lupus erythematosus (HP:0002725)4.18059386
14Vasculitis (HP:0002633)4.05113855
15Recurrent skin infections (HP:0001581)3.95813466
16Orchitis (HP:0100796)3.90219248
17Keratoconjunctivitis (HP:0001096)3.89700450
18Tetraparesis (HP:0002273)3.87658469
19Myositis (HP:0100614)3.79563777
20Gingivitis (HP:0000230)3.78574012
21Increased cerebral lipofuscin (HP:0011813)3.75589161
22Hypergammaglobulinemia (HP:0010702)3.72521947
23Recurrent viral infections (HP:0004429)3.68061190
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.61540437
25Vacuolated lymphocytes (HP:0001922)3.60915641
26Optic neuritis (HP:0100653)3.57804415
27Retrobulbar optic neuritis (HP:0100654)3.57804415
28Recurrent fungal infections (HP:0002841)3.52186579
29Prostate neoplasm (HP:0100787)3.51842523
30Porencephaly (HP:0002132)3.48302615
31Interstitial pulmonary disease (HP:0006530)3.37682583
32Encephalitis (HP:0002383)3.21536896
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.16606343
34Chronic obstructive pulmonary disease (HP:0006510)3.16057766
35Obstructive lung disease (HP:0006536)3.16057766
36Nasal polyposis (HP:0100582)3.13634148
37Abnormality of T cell number (HP:0011839)3.04283662
38T lymphocytopenia (HP:0005403)3.02744594
39Thick nail (HP:0001805)3.02204555
40Autoimmune hemolytic anemia (HP:0001890)2.98598570
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.95918332
42Periodontitis (HP:0000704)2.94136209
43Pulmonary infiltrates (HP:0002113)2.88565521
44Abnormality of the nasal mucosa (HP:0000433)2.87674477
45Gangrene (HP:0100758)2.84804365
46Axonal loss (HP:0003447)2.84299455
47Abnormality of liposaccharide metabolism (HP:0010968)2.82325480
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.82325480
49Abnormality of glycolipid metabolism (HP:0010969)2.82325480
50Pustule (HP:0200039)2.81049353
51Chronic mucocutaneous candidiasis (HP:0002728)2.76305888
52Recurrent cutaneous fungal infections (HP:0011370)2.76305888
53Poor head control (HP:0002421)2.70783981
54Urticaria (HP:0001025)2.69453809
55Premature loss of primary teeth (HP:0006323)2.67160270
56Increased IgE level (HP:0003212)2.66658247
57Chronic sinusitis (HP:0011109)2.65605511
58Recurrent bronchitis (HP:0002837)2.62460027
59Disinhibition (HP:0000734)2.61666889
60Esophageal neoplasm (HP:0100751)2.60343499
61Neoplasm of head and neck (HP:0012288)2.60343499
62Cellulitis (HP:0100658)2.58016726
63Peritonitis (HP:0002586)2.57917075
64Cleft eyelid (HP:0000625)2.56517137
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53281894
66Recurrent pneumonia (HP:0006532)2.45347929
67Pulmonary embolism (HP:0002204)2.43255497
68Lower limb hyperreflexia (HP:0002395)2.41088437
69Dysostosis multiplex (HP:0000943)2.38577310
70Hematochezia (HP:0002573)2.38442876
71Recurrent lower respiratory tract infections (HP:0002783)2.38280350
72Petechiae (HP:0000967)2.36731546
73Purpura (HP:0000979)2.35686458
74Gingival bleeding (HP:0000225)2.34520014
75Hepatosplenomegaly (HP:0001433)2.33934303
76Episodic fever (HP:0001954)2.32913807
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32480318
78Joint swelling (HP:0001386)2.31785006
79Loss of speech (HP:0002371)2.30997983
80Chest pain (HP:0100749)2.29409872
81Abnormality of the endocardium (HP:0004306)2.29100551
82Leukocytosis (HP:0001974)2.28661517
83Glomerulonephritis (HP:0000099)2.27725641
84Polyneuropathy (HP:0001271)2.27707583
85Amyloidosis (HP:0011034)2.27366997
86Vertigo (HP:0002321)2.25985847
87Spontaneous hematomas (HP:0007420)2.25639747
88Colitis (HP:0002583)2.23192066
89Osteomyelitis (HP:0002754)2.22626498
90Vertebral compression fractures (HP:0002953)2.22019209
91Bone pain (HP:0002653)2.21344069
92Abnormality of the pericardium (HP:0001697)2.21066837
93Gastrointestinal infarctions (HP:0005244)2.20675691
94Abnormality of B cell number (HP:0010975)2.19976027
95Abnormality of T cells (HP:0002843)2.19558886
96Nephritis (HP:0000123)2.19490840
97Pathologic fracture (HP:0002756)2.16781411
98Spastic tetraparesis (HP:0001285)2.15954055
99Urinary glycosaminoglycan excretion (HP:0003541)2.15822632
100Mucopolysacchariduria (HP:0008155)2.15822632
101Prolonged bleeding time (HP:0003010)2.15370848
102Meningitis (HP:0001287)2.15108477
103Plagiocephaly (HP:0001357)2.14755239
104Granulocytopenia (HP:0001913)2.14666243
105Hemoptysis (HP:0002105)2.14596424
106Acne (HP:0001061)2.13185815
107Abnormality of iron homeostasis (HP:0011031)2.12984484
108Arterial thrombosis (HP:0004420)2.12692140
109Inflammation of the large intestine (HP:0002037)2.10840610
110Progressive neurologic deterioration (HP:0002344)2.09990684
111Osteolytic defects of the phalanges of the hand (HP:0009771)2.09813572
112Osteolytic defects of the hand bones (HP:0009699)2.09813572
113Keratitis (HP:0000491)2.08922677
114Increased serum ferritin (HP:0003281)2.08869349
115Myocardial infarction (HP:0001658)2.08731967
116Glomerulopathy (HP:0100820)2.08246230
117Progressive visual loss (HP:0000529)2.05881426
118Epistaxis (HP:0000421)2.05698050
119Abnormality of the basal ganglia (HP:0002134)2.03816770
120Gastrointestinal inflammation (HP:0004386)2.03399797
121Hypertensive crisis (HP:0100735)2.02813340
122Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00820932
123Abnormality of polysaccharide metabolism (HP:0011012)2.00820932
124Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00820932
125Abnormality of the peritoneum (HP:0002585)2.00377823
126Abnormality of the pleura (HP:0002103)1.96921708
127Anorexia (HP:0002039)1.94532409
128Hemorrhage of the eye (HP:0011885)1.94374179
129Arthralgia (HP:0002829)1.94082265
130Keratoconjunctivitis sicca (HP:0001097)1.93518630
131Eosinophilia (HP:0001880)1.91534684
132Skin ulcer (HP:0200042)1.90861376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.05169816
2TYK24.30930397
3TBK14.22451301
4MAP3K144.19919805
5RIPK43.89876720
6IKBKE3.86321156
7IRAK43.22253876
8BLK2.82405150
9JAK32.75283208
10JAK12.68375869
11MAP3K132.66437169
12IRAK32.59522480
13PRPF4B2.58447505
14KIT2.40081620
15PIM22.29419659
16ERN12.24413424
17IKBKB2.16236023
18ARAF2.09425045
19TAOK21.89656896
20MAP2K31.80006828
21FGFR41.63900075
22TXK1.60733483
23CSK1.59201292
24MAP4K11.52729516
25BMPR21.51877007
26MATK1.48052989
27MAP3K31.44862191
28TAOK11.41687636
29MAP3K51.36244923
30FGR1.32300329
31SYK1.31382752
32IRAK11.26872137
33DDR21.21466482
34ZAP701.19489932
35CHUK1.16428678
36BMX1.16031314
37MAP3K91.14552667
38HCK1.14006883
39NME21.11042063
40MST41.09819527
41TNK21.09511468
42IRAK21.09067957
43ABL21.08396479
44FGFR31.07134805
45CDC42BPA1.06228076
46EPHB11.05087785
47MARK31.04269080
48RPS6KA41.03205033
49JAK21.01586181
50EIF2AK20.99639978
51LYN0.94834784
52EPHA30.93206981
53LCK0.88846108
54KSR20.87543715
55TAOK30.86719817
56FES0.86468216
57MST1R0.82330125
58NEK90.77808425
59SIK30.77423490
60PIM10.72922389
61ITK0.72759155
62GRK60.71429447
63CLK10.71393455
64PLK20.69115672
65STK40.65432020
66MOS0.63752675
67DAPK20.63617285
68PRKCD0.61522182
69MAP3K10.59652118
70EGFR0.58979269
71CSF1R0.56317436
72MAP3K120.53504755
73ABL10.52403047
74PRKCQ0.50462720
75TRIB30.48603323
76DAPK30.47990610
77MAPK70.47475926
78GRK70.46814593
79BTK0.45036521
80DYRK30.44276857
81SIK20.42576050
82CDK60.40428768
83ERBB30.39329744
84RIPK10.36760314
85MAP2K60.36723203
86MAP3K110.35679710
87TESK20.35194202
88RAF10.34537572
89BRAF0.34291242
90MAP3K60.33811362
91TYRO30.32066493
92PDPK10.31628464
93CDK40.31554249
94YES10.31134828
95TEC0.30982168
96NLK0.30307907
97PRKD20.30155358
98FYN0.29666330
99STK30.29596594
100STK100.29528296
101RPS6KL10.27961443
102RPS6KC10.27961443
103MARK20.27773484
104ERBB40.25878694
105ADRBK20.25435878
106STK240.24796366
107PIK3CG0.24557392
108MAP3K100.24099094
109RPS6KA50.23246857
110PRKG20.22602759
111PDK10.22387326
112TRPM70.20544692
113MAPK40.20369373
114MAPK110.20366018
115RPS6KA60.20336991
116MAPK30.19286524
117PRKCE0.18893150
118SGK10.16964769
119TGFBR20.16814426
120IGF1R0.15859048
121MAPKAPK20.15747386
122SRC0.15576425
123BMPR1B0.14797630
124TESK10.14179502
125INSR0.13632532
126NTRK10.11043103
127GRK50.09923126
128ALK0.08577591
129HIPK20.08491322

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046203.50633068
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.49869551
3Leishmaniasis_Homo sapiens_hsa051403.29643408
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.24287306
5Graft-versus-host disease_Homo sapiens_hsa053323.02156494
6Staphylococcus aureus infection_Homo sapiens_hsa051502.86396253
7Allograft rejection_Homo sapiens_hsa053302.68548334
8Influenza A_Homo sapiens_hsa051642.63025924
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.52924337
10Measles_Homo sapiens_hsa051622.50761704
11Malaria_Homo sapiens_hsa051442.38088987
12Pertussis_Homo sapiens_hsa051332.35810612
13Legionellosis_Homo sapiens_hsa051342.31705721
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.30419764
15Rheumatoid arthritis_Homo sapiens_hsa053232.24356734
16Asthma_Homo sapiens_hsa053102.19131816
17TNF signaling pathway_Homo sapiens_hsa046682.18602863
18Tuberculosis_Homo sapiens_hsa051522.12559286
19Osteoclast differentiation_Homo sapiens_hsa043802.08626639
20Intestinal immune network for IgA production_Homo sapiens_hsa046722.05715186
21African trypanosomiasis_Homo sapiens_hsa051432.01773281
22Herpes simplex infection_Homo sapiens_hsa051682.01285121
23Type I diabetes mellitus_Homo sapiens_hsa049401.99905087
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78885493
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64808807
26Toxoplasmosis_Homo sapiens_hsa051451.63063670
27Salmonella infection_Homo sapiens_hsa051321.62359708
28Hepatitis C_Homo sapiens_hsa051601.51929992
29Phagosome_Homo sapiens_hsa041451.45014218
30Lysosome_Homo sapiens_hsa041421.39823870
31Chemokine signaling pathway_Homo sapiens_hsa040621.36576103
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31199605
33Antigen processing and presentation_Homo sapiens_hsa046121.27128862
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26894477
35Hepatitis B_Homo sapiens_hsa051611.21973897
36Autoimmune thyroid disease_Homo sapiens_hsa053201.21212469
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.19980026
38Apoptosis_Homo sapiens_hsa042101.18710621
39B cell receptor signaling pathway_Homo sapiens_hsa046621.18653837
40Shigellosis_Homo sapiens_hsa051311.12218303
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11482787
42Hematopoietic cell lineage_Homo sapiens_hsa046401.09409893
43Viral myocarditis_Homo sapiens_hsa054161.04442438
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04121028
45Prion diseases_Homo sapiens_hsa050200.97814335
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94813036
47Primary immunodeficiency_Homo sapiens_hsa053400.92132721
48Amoebiasis_Homo sapiens_hsa051460.86623419
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84534709
50Collecting duct acid secretion_Homo sapiens_hsa049660.77656653
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77420887
52Prolactin signaling pathway_Homo sapiens_hsa049170.76380149
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74795920
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.72783388
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.71900742
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70482788
57Type II diabetes mellitus_Homo sapiens_hsa049300.64905134
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62818059
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58241647
60Other glycan degradation_Homo sapiens_hsa005110.53303552
61Bladder cancer_Homo sapiens_hsa052190.51630691
62Acute myeloid leukemia_Homo sapiens_hsa052210.51587483
63Mineral absorption_Homo sapiens_hsa049780.50302871
64T cell receptor signaling pathway_Homo sapiens_hsa046600.49826539
65Caffeine metabolism_Homo sapiens_hsa002320.49537432
66HIF-1 signaling pathway_Homo sapiens_hsa040660.47761093
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.46689578
68Dorso-ventral axis formation_Homo sapiens_hsa043200.44638199
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.43808695
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.43168517
71Epstein-Barr virus infection_Homo sapiens_hsa051690.42250072
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40597875
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40397605
74Non-small cell lung cancer_Homo sapiens_hsa052230.37802223
75Pancreatic cancer_Homo sapiens_hsa052120.35095218
76FoxO signaling pathway_Homo sapiens_hsa040680.34740795
77Chronic myeloid leukemia_Homo sapiens_hsa052200.34489794
78Complement and coagulation cascades_Homo sapiens_hsa046100.34156754
79Platelet activation_Homo sapiens_hsa046110.33893684
80Arginine biosynthesis_Homo sapiens_hsa002200.33371439
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32888150
82Small cell lung cancer_Homo sapiens_hsa052220.31512742
83Proteasome_Homo sapiens_hsa030500.29477296
84VEGF signaling pathway_Homo sapiens_hsa043700.28593524
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28541225
86Viral carcinogenesis_Homo sapiens_hsa052030.28294692
87Renal cell carcinoma_Homo sapiens_hsa052110.24485123
88Synaptic vesicle cycle_Homo sapiens_hsa047210.24266094
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23783392
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23572224
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20185155
92mTOR signaling pathway_Homo sapiens_hsa041500.19505716
93Notch signaling pathway_Homo sapiens_hsa043300.19332677
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.18604060
95Vibrio cholerae infection_Homo sapiens_hsa051100.17455564
96Insulin resistance_Homo sapiens_hsa049310.15662156
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14222127
98Prostate cancer_Homo sapiens_hsa052150.11456764
99GnRH signaling pathway_Homo sapiens_hsa049120.10652688
100Fatty acid biosynthesis_Homo sapiens_hsa000610.10066335
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09897250
102Sphingolipid metabolism_Homo sapiens_hsa006000.08230230
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07227541
104HTLV-I infection_Homo sapiens_hsa051660.07183360
105Proteoglycans in cancer_Homo sapiens_hsa052050.06691077
106MAPK signaling pathway_Homo sapiens_hsa040100.06005455
107Systemic lupus erythematosus_Homo sapiens_hsa053220.05913837
108Endocytosis_Homo sapiens_hsa041440.05235976
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05072113
110ErbB signaling pathway_Homo sapiens_hsa040120.04772778
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04510791
112Insulin signaling pathway_Homo sapiens_hsa049100.03281416
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.02897954

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