CMSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.37407129
2ribosomal small subunit assembly (GO:0000028)5.10610415
3DNA strand elongation involved in DNA replication (GO:0006271)4.89469328
4telomere maintenance via semi-conservative replication (GO:0032201)4.70912484
5DNA replication initiation (GO:0006270)4.69471431
6DNA strand elongation (GO:0022616)4.67823990
7purine nucleobase biosynthetic process (GO:0009113)4.63032473
8nucleobase biosynthetic process (GO:0046112)4.58891713
9maturation of SSU-rRNA (GO:0030490)4.50357189
10formation of translation preinitiation complex (GO:0001731)4.34690918
11proteasome assembly (GO:0043248)4.15755903
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15679336
13telomere maintenance via recombination (GO:0000722)4.14791406
14CENP-A containing nucleosome assembly (GO:0034080)4.14248047
15ribosome biogenesis (GO:0042254)4.09405782
16viral transcription (GO:0019083)4.04221363
17DNA unwinding involved in DNA replication (GO:0006268)4.03462689
18ribosomal small subunit biogenesis (GO:0042274)4.01123331
19ribonucleoprotein complex biogenesis (GO:0022613)3.99830775
20translational termination (GO:0006415)3.99543151
21chromatin remodeling at centromere (GO:0031055)3.99332741
22DNA replication checkpoint (GO:0000076)3.95638513
23ribosomal large subunit biogenesis (GO:0042273)3.95294902
24IMP biosynthetic process (GO:0006188)3.93030793
25mitotic metaphase plate congression (GO:0007080)3.92631893
26mitotic recombination (GO:0006312)3.86332615
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.82792765
28telomere maintenance via telomere lengthening (GO:0010833)3.82600757
29translational elongation (GO:0006414)3.81407483
30chaperone-mediated protein transport (GO:0072321)3.79634028
31pseudouridine synthesis (GO:0001522)3.76238467
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.75465349
33termination of RNA polymerase III transcription (GO:0006386)3.75465349
34protein complex biogenesis (GO:0070271)3.71799072
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.71739281
36spliceosomal snRNP assembly (GO:0000387)3.71687187
37rRNA processing (GO:0006364)3.71518942
38mitochondrial respiratory chain complex assembly (GO:0033108)3.70177621
39translational initiation (GO:0006413)3.69264302
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67698680
41DNA replication-independent nucleosome assembly (GO:0006336)3.64064441
42DNA replication-independent nucleosome organization (GO:0034724)3.64064441
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63222186
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.63222186
45NADH dehydrogenase complex assembly (GO:0010257)3.63222186
46protein localization to kinetochore (GO:0034501)3.60841154
47rRNA metabolic process (GO:0016072)3.60773104
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59230836
49ribosome assembly (GO:0042255)3.57955043
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57483845
51rRNA modification (GO:0000154)3.56329127
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.54256766
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53756598
54ATP synthesis coupled proton transport (GO:0015986)3.53756598
55IMP metabolic process (GO:0046040)3.52381292
56transcription-coupled nucleotide-excision repair (GO:0006283)3.49836501
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49571188
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47774616
59metaphase plate congression (GO:0051310)3.45544850
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45103046
61kinetochore organization (GO:0051383)3.44130322
62histone exchange (GO:0043486)3.40357145
63cotranslational protein targeting to membrane (GO:0006613)3.39520037
64protein targeting to ER (GO:0045047)3.35838810
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34451836
66cellular component biogenesis (GO:0044085)3.34293843
67negative regulation of ligase activity (GO:0051352)3.33280179
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33280179
69translation (GO:0006412)3.33260990
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31699943
71kinetochore assembly (GO:0051382)3.29855027
72DNA replication-dependent nucleosome assembly (GO:0006335)3.27880801
73DNA replication-dependent nucleosome organization (GO:0034723)3.27880801
74establishment of integrated proviral latency (GO:0075713)3.27773313
75spliceosomal complex assembly (GO:0000245)3.27279099
767-methylguanosine mRNA capping (GO:0006370)3.27053513
77mitotic nuclear envelope disassembly (GO:0007077)3.25766866
78respiratory chain complex IV assembly (GO:0008535)3.23495774
79replication fork processing (GO:0031297)3.22740698
80recombinational repair (GO:0000725)3.21337508
81G1/S transition of mitotic cell cycle (GO:0000082)3.21018463
82cell cycle G1/S phase transition (GO:0044843)3.21018463
83transcription elongation from RNA polymerase I promoter (GO:0006362)3.20684727
84RNA capping (GO:0036260)3.20568518
857-methylguanosine RNA capping (GO:0009452)3.20568518
86protein localization to chromosome, centromeric region (GO:0071459)3.20519627
87double-strand break repair via homologous recombination (GO:0000724)3.20225939
88cellular protein complex disassembly (GO:0043624)3.19190876
89regulation of mitochondrial translation (GO:0070129)3.19186510
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19151531
91protein localization to endoplasmic reticulum (GO:0070972)3.17971310
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17920342
93termination of RNA polymerase I transcription (GO:0006363)3.17541872
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17210629
95attachment of spindle microtubules to kinetochore (GO:0008608)3.16741036
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13879453
97viral life cycle (GO:0019058)3.12413993
98maturation of 5.8S rRNA (GO:0000460)3.11890840
99respiratory electron transport chain (GO:0022904)3.11681780
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10939477
101transcription from RNA polymerase I promoter (GO:0006360)3.10475619
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09556664
103DNA double-strand break processing (GO:0000729)3.09468056
104signal peptide processing (GO:0006465)3.08815723
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06532263
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06532263
107electron transport chain (GO:0022900)3.06503280
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05311771
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05311771
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05311771
111viral mRNA export from host cell nucleus (GO:0046784)3.05008818
112establishment of chromosome localization (GO:0051303)3.04401190
113regulation of cellular amino acid metabolic process (GO:0006521)3.03410799
114protein K6-linked ubiquitination (GO:0085020)3.02893348
115cytochrome complex assembly (GO:0017004)3.02568337
116mitochondrial RNA metabolic process (GO:0000959)3.01592634
117cullin deneddylation (GO:0010388)3.01077339
118meiotic chromosome segregation (GO:0045132)3.00642434
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.00479954
120signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00479954
121positive regulation of ligase activity (GO:0051351)2.99337075
122telomere organization (GO:0032200)2.97612594
123telomere maintenance (GO:0000723)2.97061029
124signal transduction involved in cell cycle checkpoint (GO:0072395)2.96890256
125protein deneddylation (GO:0000338)2.95794642
126peptidyl-histidine modification (GO:0018202)2.94271090
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87709320
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87709320
129tRNA processing (GO:0008033)2.86932282
130regulation of mitotic spindle checkpoint (GO:1903504)2.86680585
131regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86680585
132rRNA methylation (GO:0031167)2.81319340
133regulation of centriole replication (GO:0046599)2.80972489
134mitotic sister chromatid segregation (GO:0000070)2.78658018
135transcription from mitochondrial promoter (GO:0006390)2.78553260
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.78292679
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74729992
138somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74639873
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.74639873
140kynurenine metabolic process (GO:0070189)2.71881644
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70457369
142reciprocal DNA recombination (GO:0035825)2.69130681
143reciprocal meiotic recombination (GO:0007131)2.69130681
144regulation of DNA endoreduplication (GO:0032875)2.69012404
145DNA catabolic process, exonucleolytic (GO:0000738)2.68635303
146regulation of centrosome cycle (GO:0046605)2.68540855
147ncRNA processing (GO:0034470)2.68202382
148protein targeting to mitochondrion (GO:0006626)2.67891880
149regulation of gene silencing by RNA (GO:0060966)2.67467409
150regulation of posttranscriptional gene silencing (GO:0060147)2.67467409
151regulation of gene silencing by miRNA (GO:0060964)2.67467409
152postreplication repair (GO:0006301)2.66162192
153resolution of meiotic recombination intermediates (GO:0000712)2.64298239
154behavioral response to nicotine (GO:0035095)2.62890638
155ncRNA metabolic process (GO:0034660)2.60394465
156translesion synthesis (GO:0019985)2.59686934
157DNA damage response, detection of DNA damage (GO:0042769)2.59391698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.32982037
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.55462975
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04778933
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97164602
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.54456573
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49036321
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.41826898
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40467908
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.32176552
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.19164179
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13312841
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02827015
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01684273
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00531156
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95794059
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93235921
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91654594
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53950491
19VDR_23849224_ChIP-Seq_CD4+_Human2.53170977
20XRN2_22483619_ChIP-Seq_HELA_Human2.45299165
21VDR_22108803_ChIP-Seq_LS180_Human2.40565127
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40350178
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38115116
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34350739
25EWS_26573619_Chip-Seq_HEK293_Human2.22964987
26FOXP3_21729870_ChIP-Seq_TREG_Human2.22727495
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21909386
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21107835
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20618887
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19494855
31DCP1A_22483619_ChIP-Seq_HELA_Human2.17077471
32ZNF274_21170338_ChIP-Seq_K562_Hela2.14674413
33AR_21909140_ChIP-Seq_LNCAP_Human2.09926387
34FUS_26573619_Chip-Seq_HEK293_Human2.06377454
35GABP_19822575_ChIP-Seq_HepG2_Human2.04755824
36IGF1R_20145208_ChIP-Seq_DFB_Human2.01319967
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01264566
38SRF_21415370_ChIP-Seq_HL-1_Mouse2.00166947
39TTF2_22483619_ChIP-Seq_HELA_Human1.93705785
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88609892
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88566526
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86555912
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84070654
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83603409
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82444990
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.77088761
47ELK1_19687146_ChIP-ChIP_HELA_Human1.75906733
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.75693339
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73117668
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71745360
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.70723721
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69232904
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65609151
54CIITA_25753668_ChIP-Seq_RAJI_Human1.63202686
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62668871
56GBX2_23144817_ChIP-Seq_PC3_Human1.62444399
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62169348
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61363057
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60548021
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60517971
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55490238
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.54149446
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53560315
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52823050
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47897511
66KDM5A_27292631_Chip-Seq_BREAST_Human1.40775150
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40376892
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38852105
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37417986
70TAF15_26573619_Chip-Seq_HEK293_Human1.37231390
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37156707
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36905734
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35669770
74P300_19829295_ChIP-Seq_ESCs_Human1.33917437
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30807960
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30485093
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29422601
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28566873
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26377552
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25133820
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.22055471
82TP53_22573176_ChIP-Seq_HFKS_Human1.19214191
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15530266
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15163997
85ER_23166858_ChIP-Seq_MCF-7_Human1.14761959
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13813099
87IRF1_19129219_ChIP-ChIP_H3396_Human1.10725765
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09366402
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08567235
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07713792
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07023352
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06799740
93MYC_18940864_ChIP-ChIP_HL60_Human1.03076477
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02859536
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02774029
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02611592
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02288200
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.02092960
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02044197
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01741431
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01685642
102CBP_20019798_ChIP-Seq_JUKART_Human1.01189922
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01189922
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00007238
105MYC_22102868_ChIP-Seq_BL_Human0.99468744
106TFEB_21752829_ChIP-Seq_HELA_Human0.98558587
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98527137
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98382247
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97838934
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96950891
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95126923
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93814451
113STAT3_23295773_ChIP-Seq_U87_Human0.93740800
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90731724
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90211843
116NANOG_19829295_ChIP-Seq_ESCs_Human0.88656170
117SOX2_19829295_ChIP-Seq_ESCs_Human0.88656170
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88208909
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87519343
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.86295189
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85769204
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85352921
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83718675
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.83718675
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82974743
126TCF4_23295773_ChIP-Seq_U87_Human0.82929883
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82089348
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.81952628
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81703065
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81171856
131SMAD4_21799915_ChIP-Seq_A2780_Human0.80788183
132SPI1_23547873_ChIP-Seq_NB4_Human0.79838992
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79808534
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76672251
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75699275
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.75473056
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75162930
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75113613
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73354769
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73106339
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70452460
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.69429529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.68469559
2MP0010094_abnormal_chromosome_stability4.74803077
3MP0004957_abnormal_blastocyst_morpholog4.56915295
4MP0003111_abnormal_nucleus_morphology4.34669249
5MP0008057_abnormal_DNA_replication4.02831534
6MP0003077_abnormal_cell_cycle3.98836311
7MP0008058_abnormal_DNA_repair3.85959207
8MP0008007_abnormal_cellular_replicative2.96789316
9MP0002396_abnormal_hematopoietic_system2.86583913
10MP0008932_abnormal_embryonic_tissue2.74032256
11MP0003786_premature_aging2.43402806
12MP0003123_paternal_imprinting2.30820226
13MP0001730_embryonic_growth_arrest2.20656848
14MP0006036_abnormal_mitochondrial_physio1.98234946
15MP0008877_abnormal_DNA_methylation1.95551895
16MP0003718_maternal_effect1.91533337
17MP0000350_abnormal_cell_proliferation1.90652761
18MP0002736_abnormal_nociception_after1.85711060
19MP0000372_irregular_coat_pigmentation1.80045618
20MP0003806_abnormal_nucleotide_metabolis1.75341029
21MP0003186_abnormal_redox_activity1.72278476
22MP0003646_muscle_fatigue1.72092121
23MP0009046_muscle_twitch1.69842706
24MP0004084_abnormal_cardiac_muscle1.69442913
25MP0006072_abnormal_retinal_apoptosis1.68957417
26MP0000569_abnormal_digit_pigmentation1.68221006
27MP0004147_increased_porphyrin_level1.67357708
28MP0002102_abnormal_ear_morphology1.58697335
29MP0001485_abnormal_pinna_reflex1.57474963
30MP0003136_yellow_coat_color1.53430117
31MP0001697_abnormal_embryo_size1.52885141
32MP0000490_abnormal_crypts_of1.50000651
33MP0005551_abnormal_eye_electrophysiolog1.48714098
34MP0000750_abnormal_muscle_regeneration1.47912460
35MP0001968_abnormal_touch/_nociception1.47785880
36MP0006035_abnormal_mitochondrial_morpho1.47626357
37MP0002080_prenatal_lethality1.46883547
38MP0000313_abnormal_cell_death1.46477495
39MP0005380_embryogenesis_phenotype1.44892419
40MP0001672_abnormal_embryogenesis/_devel1.44892419
41MP0003195_calcinosis1.42641848
42MP0004215_abnormal_myocardial_fiber1.42236689
43MP0006292_abnormal_olfactory_placode1.40994660
44MP0000749_muscle_degeneration1.40558830
45MP0005397_hematopoietic_system_phenotyp1.39892151
46MP0001545_abnormal_hematopoietic_system1.39892151
47MP0004808_abnormal_hematopoietic_stem1.38889332
48MP0003937_abnormal_limbs/digits/tail_de1.37832155
49MP0009379_abnormal_foot_pigmentation1.35100065
50MP0002019_abnormal_tumor_incidence1.34362719
51MP0003984_embryonic_growth_retardation1.33855871
52MP0008995_early_reproductive_senescence1.33430450
53MP0005253_abnormal_eye_physiology1.33305340
54MP0000631_abnormal_neuroendocrine_gland1.32543657
55MP0003890_abnormal_embryonic-extraembry1.32022559
56MP0003567_abnormal_fetal_cardiomyocyte1.31159327
57MP0002234_abnormal_pharynx_morphology1.28568001
58MP0002088_abnormal_embryonic_growth/wei1.28268395
59MP0004145_abnormal_muscle_electrophysio1.27946095
60MP0002132_abnormal_respiratory_system1.26430268
61MP0003221_abnormal_cardiomyocyte_apopto1.21869265
62MP0010307_abnormal_tumor_latency1.21146855
63MP0000358_abnormal_cell_content/1.20801380
64MP0004142_abnormal_muscle_tone1.20490706
65MP0002210_abnormal_sex_determination1.20136803
66MP0002160_abnormal_reproductive_system1.19982168
67MP0005646_abnormal_pituitary_gland1.17763577
68MP0005075_abnormal_melanosome_morpholog1.17074185
69MP0006276_abnormal_autonomic_nervous1.15322468
70MP0005330_cardiomyopathy1.13612386
71MP0002085_abnormal_embryonic_tissue1.13429835
72MP0003950_abnormal_plasma_membrane1.12350794
73MP0003656_abnormal_erythrocyte_physiolo1.08635473
74MP0009745_abnormal_behavioral_response1.08399102
75MP0009333_abnormal_splenocyte_physiolog1.07940588
76MP0005266_abnormal_metabolism1.06597094
77MP0001145_abnormal_male_reproductive1.06507083
78MP0003698_abnormal_male_reproductive1.05653917
79MP0002269_muscular_atrophy1.04590731
80MP0008872_abnormal_physiological_respon1.04225176
81MP0003315_abnormal_perineum_morphology1.03398274
82MP0001929_abnormal_gametogenesis1.02569616
83MP0010352_gastrointestinal_tract_polyps1.02024741
84MP0003763_abnormal_thymus_physiology1.01854489
85MP0005670_abnormal_white_adipose1.01739214
86MP0002086_abnormal_extraembryonic_tissu0.98131676
87MP0000427_abnormal_hair_cycle0.98052223
88MP0001293_anophthalmia0.97897716
89MP0001501_abnormal_sleep_pattern0.95828298
90MP0002084_abnormal_developmental_patter0.95492824
91MP0005395_other_phenotype0.95443154
92MP0002095_abnormal_skin_pigmentation0.94115232
93MP0000703_abnormal_thymus_morphology0.93148828
94MP0000653_abnormal_sex_gland0.92392434
95MP0004197_abnormal_fetal_growth/weight/0.92178855
96MP0004043_abnormal_pH_regulation0.90566347
97MP0002722_abnormal_immune_system0.90253354
98MP0003880_abnormal_central_pattern0.90239203
99MP0001853_heart_inflammation0.89602928
100MP0005174_abnormal_tail_pigmentation0.87221552
101MP0005389_reproductive_system_phenotype0.86754368
102MP0003878_abnormal_ear_physiology0.86440309
103MP0005377_hearing/vestibular/ear_phenot0.86440309
104MP0002398_abnormal_bone_marrow0.86260570
105MP0000689_abnormal_spleen_morphology0.85938178
106MP0002638_abnormal_pupillary_reflex0.85654827
107MP0004036_abnormal_muscle_relaxation0.85413812
108MP0008789_abnormal_olfactory_epithelium0.85336627
109MP0002127_abnormal_cardiovascular_syste0.83174611
110MP0002272_abnormal_nervous_system0.83146487
111MP0005645_abnormal_hypothalamus_physiol0.83048849
112MP0002837_dystrophic_cardiac_calcinosis0.82765076
113MP0001486_abnormal_startle_reflex0.82076866
114MP0001984_abnormal_olfaction0.80439434
115MP0001529_abnormal_vocalization0.80386704
116MP0001119_abnormal_female_reproductive0.79354338
117MP0003121_genomic_imprinting0.79068988
118MP0005391_vision/eye_phenotype0.77186703
119MP0009697_abnormal_copulation0.77068693
120MP0001764_abnormal_homeostasis0.75895001
121MP0003119_abnormal_digestive_system0.73032503
122MP0002938_white_spotting0.71899466
123MP0002429_abnormal_blood_cell0.71647178
124MP0005195_abnormal_posterior_eye0.71031810
125MP0010386_abnormal_urinary_bladder0.69488664
126MP0000751_myopathy0.69465782
127MP0000049_abnormal_middle_ear0.68596592
128MP0003137_abnormal_impulse_conducting0.67712039
129MP0002752_abnormal_somatic_nervous0.67477472
130MP0000383_abnormal_hair_follicle0.67473747
131MP0002067_abnormal_sensory_capabilities0.67087027
132MP0005410_abnormal_fertilization0.67042229
133MP0000647_abnormal_sebaceous_gland0.66390956
134MP0009250_abnormal_appendicular_skeleto0.66105004
135MP0005384_cellular_phenotype0.65550811
136MP0001727_abnormal_embryo_implantation0.65199601
137MP0002106_abnormal_muscle_physiology0.64441703
138MP0000015_abnormal_ear_pigmentation0.60165481
139MP0004133_heterotaxia0.59014542
140MP0001544_abnormal_cardiovascular_syste0.57699615
141MP0005385_cardiovascular_system_phenoty0.57699615
142MP0010630_abnormal_cardiac_muscle0.56450649
143MP0001919_abnormal_reproductive_system0.53964950
144MP0004233_abnormal_muscle_weight0.53054459
145MP0003828_pulmonary_edema0.52977568
146MP0002332_abnormal_exercise_endurance0.52797787
147MP0003943_abnormal_hepatobiliary_system0.52729555
148MP0000716_abnormal_immune_system0.50242151
149MP0003941_abnormal_skin_development0.49902637
150MP0008775_abnormal_heart_ventricle0.49481155
151MP0000858_altered_metastatic_potential0.49441148

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.86096384
2Abnormality of cells of the erythroid lineage (HP:0012130)4.68470661
3Abnormal number of erythroid precursors (HP:0012131)4.56960522
4Reticulocytopenia (HP:0001896)4.30066930
5Oral leukoplakia (HP:0002745)4.11261013
6Breast hypoplasia (HP:0003187)3.52506459
7Aplastic anemia (HP:0001915)3.50591909
8Cerebral hypomyelination (HP:0006808)3.49601077
9Pancreatic cysts (HP:0001737)3.23273056
10Chromsome breakage (HP:0040012)3.20953339
11Hepatocellular necrosis (HP:0001404)3.20457015
12Increased CSF lactate (HP:0002490)3.19992623
13Rough bone trabeculation (HP:0100670)3.17047897
14Colon cancer (HP:0003003)3.17046815
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16589824
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16589824
17Increased serum lactate (HP:0002151)3.14055601
18Acute necrotizing encephalopathy (HP:0006965)3.12534571
19Degeneration of anterior horn cells (HP:0002398)3.11290007
20Abnormality of the anterior horn cell (HP:0006802)3.11290007
21Carpal bone hypoplasia (HP:0001498)3.10762643
22Hepatic necrosis (HP:0002605)3.09809664
23Mitochondrial inheritance (HP:0001427)3.08344707
24Macrocytic anemia (HP:0001972)3.05659882
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99500570
26Pancreatic fibrosis (HP:0100732)2.98060570
27Abnormal mitochondria in muscle tissue (HP:0008316)2.95071920
28Increased hepatocellular lipid droplets (HP:0006565)2.89223146
29Pallor (HP:0000980)2.83384284
30Abnormality of midbrain morphology (HP:0002418)2.81873543
31Molar tooth sign on MRI (HP:0002419)2.81873543
32Abnormality of the preputium (HP:0100587)2.77279460
33Increased serum pyruvate (HP:0003542)2.76264786
34Abnormality of glycolysis (HP:0004366)2.76264786
35Patellar aplasia (HP:0006443)2.75289953
36Abnormality of alanine metabolism (HP:0010916)2.74731362
37Hyperalaninemia (HP:0003348)2.74731362
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74731362
39True hermaphroditism (HP:0010459)2.73421673
40Microretrognathia (HP:0000308)2.65719172
41Selective tooth agenesis (HP:0001592)2.65713671
42Hypoplasia of the pons (HP:0012110)2.63904226
43Meckel diverticulum (HP:0002245)2.62975283
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59479961
45Abnormality of chromosome stability (HP:0003220)2.57969366
46Aplasia/Hypoplasia of the patella (HP:0006498)2.57086214
47Lipid accumulation in hepatocytes (HP:0006561)2.56484732
48Lactic acidosis (HP:0003128)2.55663187
49Acute encephalopathy (HP:0006846)2.50545620
50Abnormality of the ileum (HP:0001549)2.48957141
51Abnormality of the pons (HP:0007361)2.47127014
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46334091
53Abnormal protein N-linked glycosylation (HP:0012347)2.46334091
54Abnormal protein glycosylation (HP:0012346)2.46334091
55Abnormal glycosylation (HP:0012345)2.46334091
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.44309357
57Absent thumb (HP:0009777)2.43046590
58Exercise intolerance (HP:0003546)2.42493885
59Bone marrow hypocellularity (HP:0005528)2.42310092
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40138506
61Premature graying of hair (HP:0002216)2.39076540
62Medulloblastoma (HP:0002885)2.38241416
63Respiratory difficulties (HP:0002880)2.32450168
6411 pairs of ribs (HP:0000878)2.31717836
65Type I transferrin isoform profile (HP:0003642)2.31326495
66Type 2 muscle fiber atrophy (HP:0003554)2.30722759
67Pancytopenia (HP:0001876)2.30328771
68Progressive macrocephaly (HP:0004481)2.30002170
69Supernumerary spleens (HP:0009799)2.29986162
70Nephronophthisis (HP:0000090)2.28876942
71Gaze-evoked nystagmus (HP:0000640)2.28508932
72Myelodysplasia (HP:0002863)2.27076947
73Ependymoma (HP:0002888)2.26591795
74Sclerocornea (HP:0000647)2.24827770
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.23301978
76Increased intramyocellular lipid droplets (HP:0012240)2.22442073
77Muscle fiber atrophy (HP:0100295)2.22396441
78Irregular epiphyses (HP:0010582)2.22167594
79Small intestinal stenosis (HP:0012848)2.21688074
80Duodenal stenosis (HP:0100867)2.21688074
81Central scotoma (HP:0000603)2.21301777
82Multiple enchondromatosis (HP:0005701)2.18927447
83Medial flaring of the eyebrow (HP:0010747)2.18876931
84Abnormality of the labia minora (HP:0012880)2.17896472
853-Methylglutaconic aciduria (HP:0003535)2.17615948
86Progressive muscle weakness (HP:0003323)2.17118771
87Abnormal trabecular bone morphology (HP:0100671)2.15907705
88Neoplasm of the pancreas (HP:0002894)2.15009800
89Microvesicular hepatic steatosis (HP:0001414)2.14857942
90Genetic anticipation (HP:0003743)2.14710902
91Congenital, generalized hypertrichosis (HP:0004540)2.12802526
92Abnormality of the renal cortex (HP:0011035)2.12733150
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11363106
94Thrombocytosis (HP:0001894)2.10828601
95Sloping forehead (HP:0000340)2.09068539
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.08709038
97Secondary amenorrhea (HP:0000869)2.07166245
98Clubbing of toes (HP:0100760)2.06248869
99Abnormal lung lobation (HP:0002101)2.04484802
100Ectopic kidney (HP:0000086)2.04125044
101CNS demyelination (HP:0007305)2.03301982
102Chronic hepatic failure (HP:0100626)2.03213760
103Type II lissencephaly (HP:0007260)2.03104079
104Exertional dyspnea (HP:0002875)2.02651440
105Horseshoe kidney (HP:0000085)2.02437706
106Triphalangeal thumb (HP:0001199)2.02433339
107Agnosia (HP:0010524)2.01835599
108Premature ovarian failure (HP:0008209)2.01641309
109Unsteady gait (HP:0002317)1.99334735
110Absent forearm bone (HP:0003953)1.98399556
111Aplasia involving forearm bones (HP:0009822)1.98399556
112CNS hypomyelination (HP:0003429)1.98273056
113Abnormality of the renal medulla (HP:0100957)1.97123106
114Sparse eyelashes (HP:0000653)1.96991798
115Respiratory failure (HP:0002878)1.96509834
116Cellular immunodeficiency (HP:0005374)1.96393024
117Volvulus (HP:0002580)1.95684776
118Renal Fanconi syndrome (HP:0001994)1.95178433
119Rhabdomyolysis (HP:0003201)1.94976010
120Reduced antithrombin III activity (HP:0001976)1.94648186
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94235710
122Emotional lability (HP:0000712)1.91119195
123Renal cortical cysts (HP:0000803)1.90383378
124Abnormal number of incisors (HP:0011064)1.90223026
125Megaloblastic anemia (HP:0001889)1.90144466
126Increased muscle lipid content (HP:0009058)1.89740775
127Trismus (HP:0000211)1.88444615
128Attenuation of retinal blood vessels (HP:0007843)1.88163976
129Pendular nystagmus (HP:0012043)1.88042883
130Congenital stationary night blindness (HP:0007642)1.87260622
131Methylmalonic aciduria (HP:0012120)1.85914220
132Leukodystrophy (HP:0002415)1.85722072
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.85207606
134Abnormality of the renal collecting system (HP:0004742)1.84631364
135Impulsivity (HP:0100710)1.84082247
136Cystic liver disease (HP:0006706)1.83237819
137Cerebellar dysplasia (HP:0007033)1.82785665
138Small hand (HP:0200055)1.82516441
139Methylmalonic acidemia (HP:0002912)1.82074723
140Hyperglycinemia (HP:0002154)1.81939369
141Petechiae (HP:0000967)1.81424409
142Optic disc pallor (HP:0000543)1.81146153
143Abnormality of serum amino acid levels (HP:0003112)1.81005209
144Areflexia of lower limbs (HP:0002522)1.80659187
145Absent radius (HP:0003974)1.80326511
146Cerebral edema (HP:0002181)1.79989166
147Abnormality of the duodenum (HP:0002246)1.79502157
148Congenital primary aphakia (HP:0007707)1.79358432
149Abnormality of the carotid arteries (HP:0005344)1.76597536
150Duplicated collecting system (HP:0000081)1.75671397
151Scotoma (HP:0000575)1.75317639
152Anencephaly (HP:0002323)1.71860993
153Progressive cerebellar ataxia (HP:0002073)1.71387603
154Gait imbalance (HP:0002141)1.70737881
155Preaxial hand polydactyly (HP:0001177)1.69765539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.43555175
2FRK5.33925660
3WEE14.11482496
4EIF2AK13.98371430
5STK163.26526792
6CDC73.22277018
7NEK12.81141412
8VRK22.80981389
9SRPK12.77055739
10BMPR1B2.66207605
11PLK42.62431754
12TSSK62.55649463
13PBK2.50061514
14NME22.33500301
15VRK12.28648822
16EIF2AK32.27249339
17CCNB12.19429825
18BRSK22.19124838
19NEK22.04489030
20NUAK12.03356065
21ACVR1B1.95381936
22INSRR1.88585926
23TTK1.80148679
24PLK11.79353448
25PASK1.67525975
26MKNK11.65059226
27AURKB1.58405080
28RPS6KB21.51775031
29BRSK11.47580434
30PLK31.46260800
31TLK11.46159390
32NME11.43310397
33ATR1.39372683
34ZAK1.37645091
35BCKDK1.36893858
36DYRK31.36752152
37CDK71.33233961
38TGFBR11.33051571
39WNK31.32164200
40MAP4K21.31354068
41TESK21.30765474
42AURKA1.27036514
43ADRBK21.25861973
44TAF11.23001734
45TNIK1.18094715
46PNCK1.17081846
47OXSR11.16076048
48PDK31.15206914
49PDK41.15206914
50PIM21.14215265
51CHEK21.14207073
52MKNK21.13104781
53RPS6KA40.98252631
54SCYL20.98084977
55GRK10.97445536
56MAP2K30.97041616
57CDK80.96576915
58MAP3K110.96322788
59KDR0.94460020
60STK390.94095973
61MAP3K80.87879504
62CHEK10.87731806
63MAP3K40.85919634
64EIF2AK20.85286525
65EPHA40.83677048
66MAPKAPK30.83125815
67CASK0.81929124
68STK40.79975882
69STK100.79722490
70CDK40.77501239
71PLK20.75861741
72BRAF0.75525341
73EEF2K0.73088646
74CSNK2A10.71768949
75TRIM280.71404691
76CSNK2A20.70878892
77FLT30.70234354
78STK30.66851243
79PAK40.66851060
80MAPK130.64872355
81ADRBK10.64573782
82LMTK20.63189209
83ATM0.63185342
84WNK40.60861455
85CDK190.59730449
86PRKCG0.57996577
87TESK10.57632647
88MAP2K70.56770516
89CDK20.54719093
90OBSCN0.54619708
91MAP3K120.53948976
92CDK30.53045890
93TAOK20.51511784
94CSNK1E0.51300033
95PIK3CG0.51241268
96LRRK20.50950477
97MYLK0.50476516
98CSNK1G10.50075209
99PAK10.49752480
100MELK0.48960247
101MAPKAPK50.48642840
102AKT30.48640861
103MAP3K30.47821128
104STK240.46841117
105LATS10.45624909
106PDK20.44582739
107PIM10.44206052
108CDK10.42145306
109MAP3K50.41727472
110TEC0.41186255
111RPS6KA50.40267592
112CSNK1A1L0.39764320
113PRKCE0.39102475
114PRKACB0.38309101
115MST40.37881196
116CSNK1G30.37483566
117CLK10.36355476
118LIMK10.36328808
119PINK10.36063464
120CSNK1G20.34755314
121PRKDC0.34723917
122PHKG20.34107779
123PHKG10.34107779
124AKT20.33128244
125ILK0.32699392
126CAMK2A0.32427686
127MAP4K10.32370537
128DAPK10.31642947
129TAOK30.31463458
130NTRK30.30004387
131DYRK20.29728134
132PKN10.29711365
133MAP2K60.29646643
134CSNK1A10.29104924
135ZAP700.29037399
136TTN0.29001551
137BTK0.28126222
138TIE10.27315444
139PRKCI0.27275286
140KIT0.25180639
141RPS6KC10.25044723
142RPS6KL10.25044723
143MUSK0.23714328
144STK38L0.23587118
145EPHA20.22382478
146RPS6KA60.20643910

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82796402
2Mismatch repair_Homo sapiens_hsa034304.06100545
3Ribosome_Homo sapiens_hsa030104.00726154
4Proteasome_Homo sapiens_hsa030503.89332901
5RNA polymerase_Homo sapiens_hsa030203.73023346
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44500904
7Spliceosome_Homo sapiens_hsa030403.15516878
8Homologous recombination_Homo sapiens_hsa034403.09304831
9Base excision repair_Homo sapiens_hsa034102.99796249
10Nucleotide excision repair_Homo sapiens_hsa034202.94393972
11Pyrimidine metabolism_Homo sapiens_hsa002402.80388419
12RNA transport_Homo sapiens_hsa030132.78278120
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46739410
14Cell cycle_Homo sapiens_hsa041102.28224301
15One carbon pool by folate_Homo sapiens_hsa006702.13228060
16Fanconi anemia pathway_Homo sapiens_hsa034602.07646428
17Non-homologous end-joining_Homo sapiens_hsa034502.03484146
18RNA degradation_Homo sapiens_hsa030181.87714146
19Basal transcription factors_Homo sapiens_hsa030221.86010545
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73177615
21Parkinsons disease_Homo sapiens_hsa050121.68549495
22Purine metabolism_Homo sapiens_hsa002301.65044551
23Oxidative phosphorylation_Homo sapiens_hsa001901.56381838
24Huntingtons disease_Homo sapiens_hsa050161.43059970
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33336380
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30581275
27Butanoate metabolism_Homo sapiens_hsa006501.29694372
28mRNA surveillance pathway_Homo sapiens_hsa030151.19933312
29Protein export_Homo sapiens_hsa030601.15138180
30p53 signaling pathway_Homo sapiens_hsa041151.15076099
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.13634955
32Phototransduction_Homo sapiens_hsa047441.13410718
33Biosynthesis of amino acids_Homo sapiens_hsa012301.12611941
34Vitamin B6 metabolism_Homo sapiens_hsa007501.11248240
35Tryptophan metabolism_Homo sapiens_hsa003801.09822996
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08025039
37Carbon metabolism_Homo sapiens_hsa012001.06654682
38Epstein-Barr virus infection_Homo sapiens_hsa051691.04040734
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.03193815
40Folate biosynthesis_Homo sapiens_hsa007901.03100035
41Pentose phosphate pathway_Homo sapiens_hsa000300.98907001
42Nicotine addiction_Homo sapiens_hsa050330.98848838
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94014773
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91699301
45Systemic lupus erythematosus_Homo sapiens_hsa053220.84580884
46Alzheimers disease_Homo sapiens_hsa050100.82946021
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80582349
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75504721
49Nitrogen metabolism_Homo sapiens_hsa009100.74420629
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73710333
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.73703914
52Selenocompound metabolism_Homo sapiens_hsa004500.73547689
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.71056271
54Oocyte meiosis_Homo sapiens_hsa041140.70781579
55Glutathione metabolism_Homo sapiens_hsa004800.70693348
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70432042
57Sulfur relay system_Homo sapiens_hsa041220.69945863
58Taste transduction_Homo sapiens_hsa047420.69043285
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68396043
60Fructose and mannose metabolism_Homo sapiens_hsa000510.68308209
61beta-Alanine metabolism_Homo sapiens_hsa004100.63953775
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63837987
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63718603
64Olfactory transduction_Homo sapiens_hsa047400.62810265
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59551139
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.58176123
67Cardiac muscle contraction_Homo sapiens_hsa042600.57629252
68Herpes simplex infection_Homo sapiens_hsa051680.56952807
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56576521
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55892112
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54771390
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54724621
73Galactose metabolism_Homo sapiens_hsa000520.54103582
74Peroxisome_Homo sapiens_hsa041460.53251269
75Lysine degradation_Homo sapiens_hsa003100.53054227
76Retinol metabolism_Homo sapiens_hsa008300.51794419
77Viral carcinogenesis_Homo sapiens_hsa052030.51401051
78Metabolic pathways_Homo sapiens_hsa011000.51289617
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51136391
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50737281
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50094087
82Antigen processing and presentation_Homo sapiens_hsa046120.49167382
83Propanoate metabolism_Homo sapiens_hsa006400.49072611
84Chemical carcinogenesis_Homo sapiens_hsa052040.49048533
85Pyruvate metabolism_Homo sapiens_hsa006200.48536413
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48342496
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45889110
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45611560
89Ether lipid metabolism_Homo sapiens_hsa005650.42641864
90HTLV-I infection_Homo sapiens_hsa051660.41246135
91ABC transporters_Homo sapiens_hsa020100.40744810
92N-Glycan biosynthesis_Homo sapiens_hsa005100.40589351
93Thyroid cancer_Homo sapiens_hsa052160.39276699
94Morphine addiction_Homo sapiens_hsa050320.37584853
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33374470
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.32938877
97Legionellosis_Homo sapiens_hsa051340.32884793
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31713416
99Arachidonic acid metabolism_Homo sapiens_hsa005900.30351836
100Fatty acid metabolism_Homo sapiens_hsa012120.27990670
101Primary immunodeficiency_Homo sapiens_hsa053400.27966845
102Regulation of autophagy_Homo sapiens_hsa041400.27770932
103Arginine and proline metabolism_Homo sapiens_hsa003300.26208198
104Glycerolipid metabolism_Homo sapiens_hsa005610.26082178
105TGF-beta signaling pathway_Homo sapiens_hsa043500.25533381
106Serotonergic synapse_Homo sapiens_hsa047260.21429642
107Steroid biosynthesis_Homo sapiens_hsa001000.20154687
108Sulfur metabolism_Homo sapiens_hsa009200.19964354
109Alcoholism_Homo sapiens_hsa050340.19595607
110Calcium signaling pathway_Homo sapiens_hsa040200.19575173
111GABAergic synapse_Homo sapiens_hsa047270.18812732
112Vitamin digestion and absorption_Homo sapiens_hsa049770.18295153
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18006670
114Glutamatergic synapse_Homo sapiens_hsa047240.17494514
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17239560
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17164119
117HIF-1 signaling pathway_Homo sapiens_hsa040660.14659344
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12416886
119Apoptosis_Homo sapiens_hsa042100.11192236
120Renin-angiotensin system_Homo sapiens_hsa046140.10704221
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07497192
122Linoleic acid metabolism_Homo sapiens_hsa005910.06624104
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06516476
124Hematopoietic cell lineage_Homo sapiens_hsa046400.06185220
125Small cell lung cancer_Homo sapiens_hsa052220.05980851
126Measles_Homo sapiens_hsa051620.03389485
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02708004
128Shigellosis_Homo sapiens_hsa051310.01490192
129Fatty acid elongation_Homo sapiens_hsa000620.01236510
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0725286
131alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0723802
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0700503
133Influenza A_Homo sapiens_hsa05164-0.0664564
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0570363
135Fatty acid degradation_Homo sapiens_hsa00071-0.0448843
136MicroRNAs in cancer_Homo sapiens_hsa05206-0.0422223
137Hepatitis B_Homo sapiens_hsa05161-0.0409058
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0282839

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