CMTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.97003417
2epithelial cilium movement (GO:0003351)9.84721362
3spermatid development (GO:0007286)9.60405794
4reproduction (GO:0000003)9.37285913
5piRNA metabolic process (GO:0034587)8.89604386
6regulation of cilium movement (GO:0003352)8.59081902
7cilium movement (GO:0003341)8.18299476
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.93013115
9male meiosis (GO:0007140)7.74907640
10single fertilization (GO:0007338)7.51252141
11synaptonemal complex organization (GO:0070193)7.47725577
12synaptonemal complex assembly (GO:0007130)7.18410084
13sperm capacitation (GO:0048240)6.80568606
14negative regulation of inclusion body assembly (GO:0090084)6.75380843
15spermatogenesis (GO:0007283)6.54035415
16male gamete generation (GO:0048232)6.51453412
17microtubule depolymerization (GO:0007019)6.43675361
18fertilization (GO:0009566)6.42702886
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.23451373
20negative regulation of cell killing (GO:0031342)6.23451373
21organic cation transport (GO:0015695)6.05141469
22gamete generation (GO:0007276)5.99367630
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68943227
24DNA methylation involved in gamete generation (GO:0043046)5.49633280
25regulation of inclusion body assembly (GO:0090083)5.48693619
26germ cell development (GO:0007281)5.44111940
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.39677027
28male meiosis I (GO:0007141)5.36163971
29calcium ion-dependent exocytosis (GO:0017156)5.28575417
30ventricular system development (GO:0021591)5.26909044
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.26479773
32regulation of B cell receptor signaling pathway (GO:0050855)5.14871674
33cellular response to interleukin-15 (GO:0071350)5.08962638
34chromosome organization involved in meiosis (GO:0070192)5.03210430
35dendritic cell chemotaxis (GO:0002407)5.00327820
36neutrophil activation involved in immune response (GO:0002283)4.99828862
37response to interleukin-15 (GO:0070672)4.98385766
38cell recognition (GO:0008037)4.97699757
39regulation of microtubule-based movement (GO:0060632)4.96447215
40neutrophil activation (GO:0042119)4.95556403
41positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.91499046
42positive regulation of gamma-delta T cell activation (GO:0046645)4.84462807
43tolerance induction (GO:0002507)4.80742079
44seminiferous tubule development (GO:0072520)4.80460544
45multicellular organismal reproductive process (GO:0048609)4.70484332
46spermatid nucleus differentiation (GO:0007289)4.65398590
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60919738
48microtubule severing (GO:0051013)4.60109597
49meiotic nuclear division (GO:0007126)4.58743497
50left/right pattern formation (GO:0060972)4.58215278
51granulocyte activation (GO:0036230)4.41721200
52dendritic cell migration (GO:0036336)4.40126642
53antigen processing and presentation of endogenous antigen (GO:0019883)4.34230529
54glycerol ether metabolic process (GO:0006662)4.30422190
55chromosome condensation (GO:0030261)4.30416243
56meiosis I (GO:0007127)4.21852978
57DNA packaging (GO:0006323)4.21354081
58meiotic cell cycle (GO:0051321)4.17336019
59negative regulation of type 2 immune response (GO:0002829)4.16128364
60positive regulation by symbiont of host defense response (GO:0052509)4.14965884
61modulation by symbiont of host defense response (GO:0052031)4.14965884
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14965884
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14965884
64positive regulation by organism of defense response of other organism involved in symbiotic interact4.14965884
65modulation by symbiont of host immune response (GO:0052553)4.14965884
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04347620
67T cell migration (GO:0072678)4.03491766
68negative regulation of leukocyte mediated immunity (GO:0002704)3.98106672
69detection of molecule of bacterial origin (GO:0032490)3.96395873
70ether metabolic process (GO:0018904)3.96211906
71negative thymic T cell selection (GO:0045060)3.86124486
72multicellular organismal development (GO:0007275)3.86029954
73negative T cell selection (GO:0043383)3.85380478
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.82409626
75chaperone-mediated protein complex assembly (GO:0051131)3.79984495
76leukocyte degranulation (GO:0043299)3.78880576
77cellular extravasation (GO:0045123)3.73714768
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72596804
79regulation of myeloid leukocyte mediated immunity (GO:0002886)3.72552765
80germinal center formation (GO:0002467)3.72023804
81genitalia morphogenesis (GO:0035112)3.69484283
82mast cell activation (GO:0045576)3.63617454
83thrombin receptor signaling pathway (GO:0070493)3.62418243
84regulation of alpha-beta T cell proliferation (GO:0046640)3.59507017
85positive regulation of alpha-beta T cell proliferation (GO:0046641)3.57183104
86cyclooxygenase pathway (GO:0019371)3.56274956
87leukocyte migration involved in inflammatory response (GO:0002523)3.54739577
88regulation of leukocyte degranulation (GO:0043300)3.54248921
89myeloid cell activation involved in immune response (GO:0002275)3.53085527
90response to peptidoglycan (GO:0032494)3.52011311
91regulation of gamma-delta T cell activation (GO:0046643)3.50923313
92protein localization to cilium (GO:0061512)3.48893767
93lipoxygenase pathway (GO:0019372)3.48383702
94regulation of gamma-delta T cell differentiation (GO:0045586)3.47773722
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.47417925
96lymphocyte chemotaxis (GO:0048247)3.46693554
97regulation of mast cell degranulation (GO:0043304)3.46671352
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.44849429
99detection of other organism (GO:0098543)3.44473845
100G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.43051780
101neutrophil mediated immunity (GO:0002446)3.42343686
102positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42237868
103regulation of T cell mediated cytotoxicity (GO:0001914)3.40850548
104detection of external biotic stimulus (GO:0098581)3.40438585
105negative regulation of T cell mediated immunity (GO:0002710)3.39432241
106sequestering of actin monomers (GO:0042989)3.37077416
107protein polyglutamylation (GO:0018095)3.36461679
108positive regulation of macrophage differentiation (GO:0045651)3.34680395
109macrophage activation involved in immune response (GO:0002281)3.34273767
110negative regulation of T-helper cell differentiation (GO:0045623)3.33973514
111negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.33973514
112leukocyte aggregation (GO:0070486)3.31547594
113B cell receptor signaling pathway (GO:0050853)3.30728787
114negative regulation of interleukin-12 production (GO:0032695)3.29908205
115single strand break repair (GO:0000012)3.27839291
116regulation of memory T cell differentiation (GO:0043380)3.27194829
117mast cell activation involved in immune response (GO:0002279)3.26637224
118mast cell degranulation (GO:0043303)3.26637224
119positive regulation of granulocyte differentiation (GO:0030854)3.19733038
120regulation of mast cell activation involved in immune response (GO:0033006)3.19696694
121regulation of spindle checkpoint (GO:0090231)3.19317299
122immunoglobulin mediated immune response (GO:0016064)3.17582946
123gene silencing by RNA (GO:0031047)3.17222998
124microtubule polymerization or depolymerization (GO:0031109)3.16432828
125protein K11-linked deubiquitination (GO:0035871)3.16429147
126respiratory burst (GO:0045730)3.16252611
127polyol catabolic process (GO:0046174)3.15562180
128positive regulation of monocyte chemotaxis (GO:0090026)3.13378141
129synapsis (GO:0007129)3.11207946
130regulation of mast cell activation (GO:0033003)3.10512422
131detection of bacterium (GO:0016045)3.10167734
132sexual reproduction (GO:0019953)3.09835749
133production of molecular mediator involved in inflammatory response (GO:0002532)3.08836592
134amino-acid betaine transport (GO:0015838)3.08522397
135carnitine transport (GO:0015879)3.08522397
136monoubiquitinated protein deubiquitination (GO:0035520)3.06571009
137purinergic nucleotide receptor signaling pathway (GO:0035590)3.05416997
138response to host immune response (GO:0052572)3.05372858
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05372858
140regulation of T cell chemotaxis (GO:0010819)3.05034670
141positive regulation of T cell chemotaxis (GO:0010820)3.05034670
142positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.04106245
143alditol metabolic process (GO:0019400)3.03719736
144meiotic cell cycle process (GO:1903046)3.03078096
145mitotic sister chromatid cohesion (GO:0007064)3.02757671
146regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.02052722
147regulation of natural killer cell mediated immunity (GO:0002715)3.02052722
148interferon-gamma secretion (GO:0072643)3.01355128
149response to muramyl dipeptide (GO:0032495)3.01273112
150cilium organization (GO:0044782)3.01095551
151regulation of regulated secretory pathway (GO:1903305)2.98878109
152positive regulation of tumor necrosis factor production (GO:0032760)2.98541799
153carnitine transmembrane transport (GO:1902603)2.98079390
154protein refolding (GO:0042026)2.97923320
155negative regulation of T cell apoptotic process (GO:0070233)2.97922018
156negative regulation of organelle assembly (GO:1902116)2.96816474
157detection of biotic stimulus (GO:0009595)2.96178102
158negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95979475
159regulation of leukocyte mediated cytotoxicity (GO:0001910)2.93818119
160regulation of T-helper 1 type immune response (GO:0002825)2.92613093
161regulation of platelet aggregation (GO:0090330)2.91556719
162nucleus organization (GO:0006997)2.91326249
163regulation of B cell differentiation (GO:0045577)2.89860650
164cilium assembly (GO:0042384)2.88626450
165intraciliary transport (GO:0042073)2.88362621
166regulation of type 2 immune response (GO:0002828)2.86175004
167regulation of cell killing (GO:0031341)2.85461495
168Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85063365
169nucleoside diphosphate phosphorylation (GO:0006165)2.84655615
170microtubule-based movement (GO:0007018)2.84476358
171regulation of necroptotic process (GO:0060544)2.84370846
172glycolytic process (GO:0006096)2.84218976
173positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84025708
174RNA destabilization (GO:0050779)2.83950970
175axoneme assembly (GO:0035082)2.82794272
176regulation of meiosis I (GO:0060631)2.81990986
177cellular component assembly involved in morphogenesis (GO:0010927)2.78238677
178cilium morphogenesis (GO:0060271)2.72629960
179regulation of cilium assembly (GO:1902017)2.61847661
180negative regulation of skeletal muscle tissue development (GO:0048642)2.61501874
181lactate metabolic process (GO:0006089)2.60812875
182peptidyl-glutamic acid modification (GO:0018200)2.60132446
183glycerol metabolic process (GO:0006071)2.58638198
184GTP biosynthetic process (GO:0006183)2.55586082
185gene silencing (GO:0016458)2.54321127
186centriole assembly (GO:0098534)2.53972696
187RNA localization (GO:0006403)2.52634725
188fusion of sperm to egg plasma membrane (GO:0007342)13.4633062
189sperm motility (GO:0030317)13.4109829
190acrosome reaction (GO:0007340)12.0285557
191cell wall macromolecule catabolic process (GO:0016998)11.8186093
192cell wall macromolecule metabolic process (GO:0044036)11.8186093
193sperm-egg recognition (GO:0035036)11.5497894
194cilium or flagellum-dependent cell motility (GO:0001539)11.4793245
195acrosome assembly (GO:0001675)11.3519450
196multicellular organism reproduction (GO:0032504)11.1655738
197binding of sperm to zona pellucida (GO:0007339)10.5493851
198axonemal dynein complex assembly (GO:0070286)10.3708975
199cell-cell recognition (GO:0009988)10.3134376
200plasma membrane fusion (GO:0045026)10.2160826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.71592610
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.39553489
3EZH2_22144423_ChIP-Seq_EOC_Human4.39340562
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.29953628
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.28986120
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.99592085
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.89634513
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.88828851
9SCL_19346495_ChIP-Seq_HPC-7_Human3.19031181
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.14209961
11RUNX_20019798_ChIP-Seq_JUKART_Human3.13858406
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.05934640
13VDR_22108803_ChIP-Seq_LS180_Human2.91968290
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88376366
15* MYB_26560356_Chip-Seq_TH2_Human2.79580144
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73436184
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69761538
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67685777
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.67137865
20SPI1_23547873_ChIP-Seq_NB4_Human2.66161870
21* UTX_26944678_Chip-Seq_JUKART_Human2.60502398
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.60323795
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60103314
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59104337
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51621596
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.46148892
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45609403
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.43741815
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.39921936
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38918123
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38253134
32SPI1_23127762_ChIP-Seq_K562_Human2.33483662
33MAF_26560356_Chip-Seq_TH1_Human2.27700124
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.27014438
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.26967077
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23761925
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22579743
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.20600648
39GATA1_26923725_Chip-Seq_HPCs_Mouse2.16410210
40MYB_26560356_Chip-Seq_TH1_Human2.14236009
41VDR_24763502_ChIP-Seq_THP-1_Human2.12444842
42CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07160641
43ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06746297
44VDR_21846776_ChIP-Seq_THP-1_Human2.05062476
45ZNF274_21170338_ChIP-Seq_K562_Hela2.03382157
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02224039
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1173428
48GATA1_22025678_ChIP-Seq_K562_Human1.98241667
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97950325
50GATA3_27048872_Chip-Seq_THYMUS_Human1.96853861
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95997657
52MYC_22102868_ChIP-Seq_BL_Human1.89424987
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88160609
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.86434031
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.82952459
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82184721
57* MAF_26560356_Chip-Seq_TH2_Human1.78082950
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.77239643
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76823985
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75455441
61STAT1_17558387_ChIP-Seq_HELA_Human1.73312005
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.73257392
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.71359113
64* GATA3_26560356_Chip-Seq_TH2_Human1.70016629
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69929681
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.68606815
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68245676
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.67693658
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67073423
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.63770494
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.63120284
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60777179
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59954479
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55947602
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54769643
76FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54517580
77TCF7_22412390_ChIP-Seq_EML_Mouse1.52357048
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.52295957
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50658711
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49822527
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.48252810
82GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44763585
83SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43924049
84KDM2B_26808549_Chip-Seq_REH_Human1.43326647
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.42329125
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42328191
87VDR_24787735_ChIP-Seq_THP-1_Human1.42304960
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.42216508
89GATA1_19941826_ChIP-Seq_K562_Human1.41546220
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41381810
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40025934
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37242420
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35209537
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.35136858
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34898790
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31432565
97CBP_20019798_ChIP-Seq_JUKART_Human1.31432565
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29588534
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28035645
100FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27910587
101GATA3_21867929_ChIP-Seq_TH1_Mouse1.27442616
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26891508
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26889571
104LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26846895
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26695503
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26296476
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25807024
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25187374
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23928944
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22847882
111REST_21632747_ChIP-Seq_MESCs_Mouse1.21664656
112GF1_26923725_Chip-Seq_HPCs_Mouse1.21008437
113P53_21459846_ChIP-Seq_SAOS-2_Human1.20703742
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.18347107
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18220639
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.17900982
117RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17760523
118PU_27001747_Chip-Seq_BMDM_Mouse1.15943172
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.14577216
120SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14187247
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14060927
122BCL6_27268052_Chip-Seq_Bcells_Human1.12215463
123CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11967831
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11643701
125KDM2B_26808549_Chip-Seq_DND41_Human1.10838197
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10699298
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10699298
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10417520
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10294276
130GATA2_19941826_ChIP-Seq_K562_Human1.10058301
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.08021011
132RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07613868
133BCOR_27268052_Chip-Seq_Bcells_Human1.07595343
134EZH2_27294783_Chip-Seq_NPCs_Mouse1.07137903
135RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06941040
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.06746284
137SPI1_20517297_ChIP-Seq_HL60_Human1.06238442
138SPI1_26923725_Chip-Seq_HPCs_Mouse1.06164705
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05499489
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05428433
141* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05139536
142CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05041281
143CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04654660
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03687705
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03272553
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02853132
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02420494
148P53_22387025_ChIP-Seq_ESCs_Mouse1.02353064
149SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02229474
150KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01044495
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00964105
152SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00514446
153ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00449824
154STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99688621
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99653408
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.98592006
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98495949
158RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97063965
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97047135
160KLF4_18555785_Chip-Seq_ESCs_Mouse0.96985497
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95387359
162CMYC_18555785_Chip-Seq_ESCs_Mouse0.95285333
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94543948
164MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94160091
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.94003184
166RNF2_27304074_Chip-Seq_NSC_Mouse0.93585465
167P300_18555785_Chip-Seq_ESCs_Mouse0.93458471
168PU1_27457419_Chip-Seq_LIVER_Mouse0.93396510
169ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92822937
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92788867
171FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92590618
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.92569909
173TAF15_26573619_Chip-Seq_HEK293_Human0.92258460
174SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92089556
175PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91969225
176RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90954533
177NFYB_21822215_ChIP-Seq_K562_Human0.90872985
178ERG_20517297_ChIP-Seq_VCAP_Human0.90430297
179EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90297417
180ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89729456
181CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89636671
182NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89324973
183NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88296607
184CTCF_20526341_ChIP-Seq_ESCs_Human0.87904219
185LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87635935
186NCOR1_26117541_ChIP-Seq_K562_Human0.87255886
187KDM2B_26808549_Chip-Seq_JURKAT_Human0.87213195
188ELF1_20517297_ChIP-Seq_JURKAT_Human0.87017535
189SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86646373
190GF1B_26923725_Chip-Seq_HPCs_Mouse0.86533526
191RARA_24833708_ChIP-Seq_LIVER_Mouse0.86428613
192TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85828237
193GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85370842
194GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85013441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.00454245
2MP0001929_abnormal_gametogenesis5.53154978
3MP0003724_increased_susceptibility_to5.28514096
4MP0003436_decreased_susceptibility_to4.58434372
5MP0008877_abnormal_DNA_methylation4.38057353
6MP0002210_abnormal_sex_determination3.55399721
7MP0005464_abnormal_platelet_physiology3.51367300
8MP0005671_abnormal_response_to3.37859017
9MP0002161_abnormal_fertility/fecundity3.30193146
10MP0005000_abnormal_immune_tolerance2.97911228
11MP0001145_abnormal_male_reproductive2.96780874
12MP0000465_gastrointestinal_hemorrhage2.96774133
13MP0003763_abnormal_thymus_physiology2.90605673
14MP0009785_altered_susceptibility_to2.89204920
15MP0001800_abnormal_humoral_immune2.75966964
16MP0003303_peritoneal_inflammation2.67420285
17MP0002653_abnormal_ependyma_morphology2.67118952
18MP0005025_abnormal_response_to2.62917557
19MP0001533_abnormal_skeleton_physiology2.59208353
20MP0002148_abnormal_hypersensitivity_rea2.59094814
21MP0000653_abnormal_sex_gland2.56897297
22MP0002420_abnormal_adaptive_immunity2.45809986
23MP0001819_abnormal_immune_cell2.45382526
24MP0002452_abnormal_antigen_presenting2.41948721
25MP0000685_abnormal_immune_system2.38773487
26MP0003866_abnormal_defecation2.35744655
27MP0005670_abnormal_white_adipose2.26587295
28MP0005387_immune_system_phenotype2.23424426
29MP0001790_abnormal_immune_system2.23424426
30MP0002398_abnormal_bone_marrow2.14563260
31MP0005410_abnormal_fertilization16.2045746
32MP0010155_abnormal_intestine_physiology1.97489465
33MP0000716_abnormal_immune_system1.89844861
34MP0002722_abnormal_immune_system1.88551928
35MP0009333_abnormal_splenocyte_physiolog1.79334641
36MP0001845_abnormal_inflammatory_respons1.76912122
37MP0000689_abnormal_spleen_morphology1.76793579
38MP0009764_decreased_sensitivity_to1.76781443
39MP0003191_abnormal_cellular_cholesterol1.73348304
40MP0003300_gastrointestinal_ulcer1.69454292
41MP0003828_pulmonary_edema1.65075281
42MP0000858_altered_metastatic_potential1.64832475
43MP0004947_skin_inflammation1.61157325
44MP0005623_abnormal_meninges_morphology1.60094644
45MP0004883_abnormal_blood_vessel1.59002911
46MP0002429_abnormal_blood_cell1.58110113
47MP0000703_abnormal_thymus_morphology1.54733029
48MP0008260_abnormal_autophagy1.53513108
49MP0006082_CNS_inflammation1.52132968
50MP0003646_muscle_fatigue1.50810228
51MP0002160_abnormal_reproductive_system1.49908329
52MP0000343_altered_response_to1.44995996
53MP0002282_abnormal_trachea_morphology1.44777103
54MP0008057_abnormal_DNA_replication1.44403284
55MP0005164_abnormal_response_to1.37951179
56MP0008469_abnormal_protein_level1.27593239
57MP0002396_abnormal_hematopoietic_system1.26666631
58MP0002998_abnormal_bone_remodeling1.24524408
59MP0002132_abnormal_respiratory_system1.23831250
60MP0003075_altered_response_to1.19597735
61MP0005390_skeleton_phenotype1.15086756
62MP0008004_abnormal_stomach_pH1.09321936
63MP0003656_abnormal_erythrocyte_physiolo1.09312515
64MP0002166_altered_tumor_susceptibility1.09019821
65MP0003011_delayed_dark_adaptation1.08292444
66MP0004381_abnormal_hair_follicle1.04686719
67MP0005166_decreased_susceptibility_to1.00721624
68MP0001765_abnormal_ion_homeostasis0.99938599
69MP0001542_abnormal_bone_strength0.97919179
70MP0008058_abnormal_DNA_repair0.97915778
71MP0004233_abnormal_muscle_weight0.97240216
72MP0009763_increased_sensitivity_to0.96198120
73MP0000249_abnormal_blood_vessel0.95465764
74MP0006054_spinal_hemorrhage0.94875584
75MP0002234_abnormal_pharynx_morphology0.94850460
76MP0000604_amyloidosis0.90800735
77MP0000015_abnormal_ear_pigmentation0.89812197
78MP0005174_abnormal_tail_pigmentation0.89781011
79MP0003172_abnormal_lysosome_physiology0.88629252
80MP0003183_abnormal_peptide_metabolism0.88574336
81MP0001984_abnormal_olfaction0.88490512
82MP0005647_abnormal_sex_gland0.84778150
83MP0003045_fibrosis0.83911581
84MP0005310_abnormal_salivary_gland0.83245838
85MP0003115_abnormal_respiratory_system0.83019352
86MP0004130_abnormal_muscle_cell0.81264741
87MP0009046_muscle_twitch0.80521023
88MP0009765_abnormal_xenobiotic_induced0.80332462
89MP0005389_reproductive_system_phenotype0.79496401
90MP0003690_abnormal_glial_cell0.78415206
91MP0008995_early_reproductive_senescence0.75921021
92MP0004147_increased_porphyrin_level0.75355354
93MP0003283_abnormal_digestive_organ0.75130404
94MP0002102_abnormal_ear_morphology0.73408770
95MP0003795_abnormal_bone_structure0.73016662
96MP0002006_tumorigenesis0.72490703
97MP0002877_abnormal_melanocyte_morpholog0.72039448
98MP0002019_abnormal_tumor_incidence0.71754275
99MP0001501_abnormal_sleep_pattern0.70375309
100MP0002928_abnormal_bile_duct0.70280449
101MP0005167_abnormal_blood-brain_barrier0.69595442
102MP0005075_abnormal_melanosome_morpholog0.68065315
103MP0001243_abnormal_dermal_layer0.67872786
104MP0010094_abnormal_chromosome_stability0.67205028
105MP0008874_decreased_physiological_sensi0.67193131
106MP0003566_abnormal_cell_adhesion0.65272447
107MP0004808_abnormal_hematopoietic_stem0.62594208
108MP0005084_abnormal_gallbladder_morpholo0.61951074
109MP0002277_abnormal_respiratory_mucosa0.61391962
110MP0009278_abnormal_bone_marrow0.60206458
111MP0005058_abnormal_lysosome_morphology0.59708984
112MP0001663_abnormal_digestive_system0.59047892
113MP0001958_emphysema0.58437962
114MP0008873_increased_physiological_sensi0.56462492
115MP0001293_anophthalmia0.56230613
116MP0004885_abnormal_endolymph0.54781138
117MP0005397_hematopoietic_system_phenotyp0.54110559
118MP0001545_abnormal_hematopoietic_system0.54110559
119MP0001324_abnormal_eye_pigmentation0.52931870
120MP0000490_abnormal_crypts_of0.51670936
121MP0004019_abnormal_vitamin_homeostasis0.51306492
122MP0000358_abnormal_cell_content/0.51280337
123MP0005451_abnormal_body_composition0.50987576
124MP0001119_abnormal_female_reproductive0.46553918
125MP0005253_abnormal_eye_physiology0.46081319
126MP0003786_premature_aging0.45341541
127MP0003950_abnormal_plasma_membrane0.41920847
128MP0005391_vision/eye_phenotype0.41682175
129MP0005636_abnormal_mineral_homeostasis0.41496907
130MP0008007_abnormal_cellular_replicative0.40309491
131MP0003699_abnormal_female_reproductive0.40231521
132MP0003315_abnormal_perineum_morphology0.38737824
133MP0003111_abnormal_nucleus_morphology0.36796037
134MP0000427_abnormal_hair_cycle0.35117329
135MP0005377_hearing/vestibular/ear_phenot0.31495381
136MP0003878_abnormal_ear_physiology0.31495381
137MP0002405_respiratory_system_inflammati0.31456740
138MP0005551_abnormal_eye_electrophysiolog0.31415253
139MP0000569_abnormal_digit_pigmentation0.30792952
140MP0005666_abnormal_adipose_tissue0.30260044
141MP0002092_abnormal_eye_morphology0.29728694
142MP0003959_abnormal_lean_body0.26542923
143MP0002736_abnormal_nociception_after0.26243850
144MP0000313_abnormal_cell_death0.25885948
145MP0005187_abnormal_penis_morphology0.23703040
146MP0010307_abnormal_tumor_latency0.23055810
147MP0003633_abnormal_nervous_system0.22600181
148MP0003861_abnormal_nervous_system0.22252621
149MP0002796_impaired_skin_barrier0.21760575
150MP0003448_altered_tumor_morphology0.21562137
151MP0000537_abnormal_urethra_morphology0.21475194
152MP0005646_abnormal_pituitary_gland0.21034656
153MP0003868_abnormal_feces_composition0.20995216
154MP0003279_aneurysm0.20684093
155MP0005503_abnormal_tendon_morphology0.20549120
156MP0002295_abnormal_pulmonary_circulatio0.20431232
157MP0001835_abnormal_antigen_presentation0.19967565
158MP0000534_abnormal_ureter_morphology0.19943658
159MP0001851_eye_inflammation0.19444898
160MP0002693_abnormal_pancreas_physiology0.19308609
161MP0001986_abnormal_taste_sensitivity0.19125642
162MP0009115_abnormal_fat_cell0.19026022
163MP0004811_abnormal_neuron_physiology0.19025511
164MP0002269_muscular_atrophy0.18914806
165MP0003329_amyloid_beta_deposits0.18693754
166MP0009672_abnormal_birth_weight0.18434197
167MP0003942_abnormal_urinary_system0.18188651
168MP0002169_no_abnormal_phenotype0.17751304
169MP0001730_embryonic_growth_arrest0.17656199
170MP0001849_ear_inflammation0.17561241
171MP0002873_normal_phenotype0.17534896
172MP0005423_abnormal_somatic_nervous0.17507947
173MP0009697_abnormal_copulation0.16396443
174MP0002723_abnormal_immune_serum0.15726179
175MP0002152_abnormal_brain_morphology0.15484013
176MP0004197_abnormal_fetal_growth/weight/0.15321303
177MP0001764_abnormal_homeostasis0.15038180
178MP0004036_abnormal_muscle_relaxation0.14923427
179MP0003077_abnormal_cell_cycle0.14784771
180MP0001727_abnormal_embryo_implantation0.14777855
181MP0002419_abnormal_innate_immunity0.14625434
182MP0002971_abnormal_brown_adipose0.13985116
183MP0003948_abnormal_gas_homeostasis0.13125769

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.19935396
2Abnormal respiratory motile cilium morphology (HP:0005938)9.19935396
3Abnormal respiratory motile cilium physiology (HP:0012261)9.19249544
4Rhinitis (HP:0012384)7.58380896
5Abnormal ciliary motility (HP:0012262)7.23749404
6Chronic bronchitis (HP:0004469)7.16235449
7Infertility (HP:0000789)6.73510325
8Nasal polyposis (HP:0100582)6.42448638
9Eczematoid dermatitis (HP:0000976)6.30617396
10Orchitis (HP:0100796)5.62060545
11Myositis (HP:0100614)5.57629305
12Optic neuritis (HP:0100653)5.37217616
13Retrobulbar optic neuritis (HP:0100654)5.37217616
14Abnormality of the nasal mucosa (HP:0000433)5.25123703
15Bronchitis (HP:0012387)4.60553155
16Bronchiectasis (HP:0002110)4.46312922
17Prolonged bleeding time (HP:0003010)4.39799834
18Stomatitis (HP:0010280)4.39330466
19Elevated erythrocyte sedimentation rate (HP:0003565)4.36801560
20Nephronophthisis (HP:0000090)4.32062780
21Recurrent fungal infections (HP:0002841)4.16299477
22Male infertility (HP:0003251)4.10843595
23Recurrent abscess formation (HP:0002722)4.07812915
24T lymphocytopenia (HP:0005403)4.00907769
25Recurrent bacterial skin infections (HP:0005406)4.00217762
26Abnormality of T cell number (HP:0011839)3.89835334
27Abnormality of macrophages (HP:0004311)3.88971836
28IgG deficiency (HP:0004315)3.87004130
29Keratoconjunctivitis sicca (HP:0001097)3.79670475
30Gastrointestinal infarctions (HP:0005244)3.78343198
31Recurrent cutaneous fungal infections (HP:0011370)3.65217725
32Chronic mucocutaneous candidiasis (HP:0002728)3.65217725
33Epistaxis (HP:0000421)3.63322751
34Chronic obstructive pulmonary disease (HP:0006510)3.62729933
35Obstructive lung disease (HP:0006536)3.62729933
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.60324669
37Keratoconjunctivitis (HP:0001096)3.60229159
38Meningitis (HP:0001287)3.60014441
39Abnormality of T cells (HP:0002843)3.59171578
40Vasculitis (HP:0002633)3.55436172
41Encephalitis (HP:0002383)3.47702190
42Recurrent otitis media (HP:0000403)3.43538696
43Recurrent sinusitis (HP:0011108)3.41709718
44Gingival bleeding (HP:0000225)3.41111205
45Arterial thrombosis (HP:0004420)3.34675976
46Petechiae (HP:0000967)3.32234145
47Abnormal spermatogenesis (HP:0008669)3.30384185
48Abnormality of the renal medulla (HP:0100957)3.27694314
49Leukocytosis (HP:0001974)3.26668118
50Abnormality of T cell physiology (HP:0011840)3.24148405
51Granulocytopenia (HP:0001913)3.19933660
52Abnormality of eosinophils (HP:0001879)3.14175284
53Recurrent skin infections (HP:0001581)3.10492296
54Mediastinal lymphadenopathy (HP:0100721)3.09157006
55Severe combined immunodeficiency (HP:0004430)3.07601242
56Chest pain (HP:0100749)3.06487567
57Spontaneous hematomas (HP:0007420)3.04080680
58Abnormal platelet volume (HP:0011876)3.03697441
59Joint swelling (HP:0001386)3.02783222
60Menorrhagia (HP:0000132)2.97501670
61Cellulitis (HP:0100658)2.94936649
62Anorexia (HP:0002039)2.91420569
63Recurrent bronchitis (HP:0002837)2.90098293
64Gonadotropin excess (HP:0000837)2.89123580
65Peritonitis (HP:0002586)2.86987924
66Agammaglobulinemia (HP:0004432)2.85560454
67Hemoptysis (HP:0002105)2.85511073
68Increased IgM level (HP:0003496)2.82999818
69Eosinophilia (HP:0001880)2.82183058
70Hepatosplenomegaly (HP:0001433)2.79152546
71Impulsivity (HP:0100710)2.77783173
72Episodic fever (HP:0001954)2.76317084
73Recurrent gram-negative bacterial infections (HP:0005420)2.73444456
74Growth hormone excess (HP:0000845)2.71008278
75Abnormality of B cell number (HP:0010975)2.70619372
76Medial flaring of the eyebrow (HP:0010747)2.70146063
77Molar tooth sign on MRI (HP:0002419)2.70083756
78Abnormality of midbrain morphology (HP:0002418)2.70083756
79Panhypogammaglobulinemia (HP:0003139)2.68237981
80B lymphocytopenia (HP:0010976)2.66220650
81Pulmonary infiltrates (HP:0002113)2.64667863
82Urticaria (HP:0001025)2.64004348
83Glomerulopathy (HP:0100820)2.61226464
84Papilledema (HP:0001085)2.57413751
85Increased mean platelet volume (HP:0011877)2.54093130
86Osteomyelitis (HP:0002754)2.51239276
87Pulmonary embolism (HP:0002204)2.48756539
88Tubulointerstitial nephritis (HP:0001970)2.47627557
89Purpura (HP:0000979)2.47580935
90Gangrene (HP:0100758)2.46105455
91Pustule (HP:0200039)2.44120722
92IgM deficiency (HP:0002850)2.40320625
93Increased IgE level (HP:0003212)2.40221576
94Combined immunodeficiency (HP:0005387)2.38740047
95Tubular atrophy (HP:0000092)2.38386598
96Stomach cancer (HP:0012126)2.38252829
97Abnormality of the pleura (HP:0002103)2.34629206
98Verrucae (HP:0200043)2.32776925
99Papilloma (HP:0012740)2.32776925
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31089015
101Recurrent viral infections (HP:0004429)2.30170196
102Sepsis (HP:0100806)2.28230033
103Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21706872
104Tubulointerstitial abnormality (HP:0001969)2.20360330
105Vertigo (HP:0002321)2.20137608
106Abnormal platelet function (HP:0011869)2.19154055
107Impaired platelet aggregation (HP:0003540)2.19154055
108Gingivitis (HP:0000230)2.17507416
109Keratitis (HP:0000491)2.16584383
110Abnormality of the peritoneum (HP:0002585)2.15841124
111Lymphopenia (HP:0001888)2.15088178
112Inflammation of the large intestine (HP:0002037)2.11323067
113Abnormality of cells of the lymphoid lineage (HP:0012140)2.11020009
114Abnormality of the endocardium (HP:0004306)2.10946883
115Hypochromic anemia (HP:0001931)2.10862804
116Gastrointestinal inflammation (HP:0004386)2.08983736
117Azoospermia (HP:0000027)2.08567567
118Acute hepatic failure (HP:0006554)2.08447545
119Hypochromic microcytic anemia (HP:0004840)2.06971247
120Skin rash (HP:0000988)2.06322066
121Gastrointestinal stroma tumor (HP:0100723)2.06120923
122Amyloidosis (HP:0011034)2.06012768
123Chronic diarrhea (HP:0002028)2.05586649
124Abnormality of the prostate (HP:0008775)2.04323846
125Abnormality of the heme biosynthetic pathway (HP:0010472)2.02236987
126Acne (HP:0001061)2.01589035
127Arthralgia (HP:0002829)2.00645177
128Abnormal gallbladder physiology (HP:0012438)2.00289427
129Cholecystitis (HP:0001082)2.00289427
130Absent/shortened dynein arms (HP:0200106)13.2775606
131Dynein arm defect of respiratory motile cilia (HP:0012255)13.2775606
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1287879
133Spastic tetraparesis (HP:0001285)1.99480791
134Postaxial foot polydactyly (HP:0001830)1.96618259
135Congenital hepatic fibrosis (HP:0002612)1.89679502
136Dyschromatopsia (HP:0007641)1.87844054
137Heterotopia (HP:0002282)1.87376932
138Deformed sella turcica (HP:0002681)1.85886778
139Fibular hypoplasia (HP:0003038)1.83832939
140Tubulointerstitial fibrosis (HP:0005576)1.83348426
141Oculomotor apraxia (HP:0000657)1.74011639
142Stage 5 chronic kidney disease (HP:0003774)1.72814561
143Absent epiphyses (HP:0010577)1.72787469
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72787469
145Decreased central vision (HP:0007663)1.70179766
146Abnormality of the lower motor neuron (HP:0002366)1.67764521
147Short ribs (HP:0000773)1.66977249
148Amyotrophic lateral sclerosis (HP:0007354)1.66610759
149Absent frontal sinuses (HP:0002688)1.65998783
150Gait imbalance (HP:0002141)1.64822405
151Aplasia/Hypoplasia of the lens (HP:0008063)1.64815797
152Bile duct proliferation (HP:0001408)1.63790686
153Abnormal biliary tract physiology (HP:0012439)1.63790686
154Congenital primary aphakia (HP:0007707)1.63772791
155Abnormality of the renal cortex (HP:0011035)1.57632926
156Postaxial hand polydactyly (HP:0001162)1.57448109
157Abnormality of renal excretion (HP:0011036)1.56059642
158Polydipsia (HP:0001959)1.55839369
159Abnormal drinking behavior (HP:0030082)1.55839369
160J-shaped sella turcica (HP:0002680)1.54485931
161Impaired proprioception (HP:0010831)1.54078459
162Renal dysplasia (HP:0000110)1.53228597
163Bell-shaped thorax (HP:0001591)1.51845687
164Choroideremia (HP:0001139)1.47497731
165Chronic sinusitis (HP:0011109)1.46826660
166Nephropathy (HP:0000112)1.45473926
167Taurodontia (HP:0000679)1.43349561
168Abnormality of permanent molar morphology (HP:0011071)1.43349561
169Abnormality of the dental root (HP:0006486)1.43349561
170Facial cleft (HP:0002006)1.42764409
171Nephrogenic diabetes insipidus (HP:0009806)1.37661938
172Chronic hepatic failure (HP:0100626)1.37163719
173Abnormality of molar morphology (HP:0011070)1.35461484
174Abnormality of molar (HP:0011077)1.35461484
175Abnormality of dentin (HP:0010299)1.34438910
176Abnormality of the sella turcica (HP:0002679)1.32585641
177Hemorrhage of the eye (HP:0011885)1.32467328
178Abnormality of the anterior horn cell (HP:0006802)1.30486365
179Degeneration of anterior horn cells (HP:0002398)1.30486365
180Abnormality of the dental pulp (HP:0006479)1.29973218
181Loss of speech (HP:0002371)1.27635260
182Abnormal urine output (HP:0012590)1.27243856
183Retinal dysplasia (HP:0007973)1.27169444
184Vaginal atresia (HP:0000148)1.26972787
185Hemiparesis (HP:0001269)1.26211231
186Short thorax (HP:0010306)1.22485992
187Genital tract atresia (HP:0001827)1.21886735
188Easy fatigability (HP:0003388)1.20563014
189Pachygyria (HP:0001302)1.20193405
190Bundle branch block (HP:0011710)1.19969537
191Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19911676
192Cystic liver disease (HP:0006706)1.19848812
193Abnormality of ocular smooth pursuit (HP:0000617)1.19064846
194Poor coordination (HP:0002370)1.18854446
195Glucose intolerance (HP:0000833)1.18335161
196Decreased electroretinogram (ERG) amplitude (HP:0000654)1.17821807
197Breast carcinoma (HP:0003002)1.16685293
198Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.16428764
199Microglossia (HP:0000171)1.14923977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.12861451
2PDK38.12861451
3TESK15.80532511
4PDK25.50969215
5PRKD35.28789077
6ICK4.06244464
7GRK63.66935765
8FES3.33445610
9TAOK33.27295783
10ERN12.79154262
11BLK2.42893887
12PTK2B2.35240405
13BMPR22.19333578
14IRAK42.18323426
15RIPK42.14822265
16TXK2.13227055
17MAP2K31.97610891
18PNCK1.95346883
19WNK41.93963105
20BTK1.87180961
21STK391.79316509
22SYK1.77306355
23TYK21.70903498
24NEK21.65482440
25HCK1.65137334
26KIT1.64562599
27STK381.59268571
28JAK11.55752565
29MAP3K131.53114423
30JAK31.52419134
31TNK21.49737459
32SIK31.38328915
33DYRK1B1.30961175
34JAK21.29012130
35MAP3K111.25049366
36LYN1.24726398
37CSF1R1.22438669
38EPHA31.21927293
39IRAK31.15422489
40ITK1.14338550
41LCK1.13609721
42PDK11.12429218
43PRPF4B1.03214217
44PIK3CA0.98960073
45MAPK70.94983884
46BCKDK0.94951444
47MAP3K70.94934651
48ARAF0.94308185
49TEC0.91928080
50IKBKB0.88729671
51KDR0.88542706
52IKBKE0.87881898
53TBK10.87248986
54KSR20.87117439
55MAP3K60.86885465
56NTRK20.86658309
57PASK0.85310955
58TYRO30.84820415
59WNK10.81722515
60STK30.81155540
61DYRK30.78566650
62FGR0.76169036
63MAPK150.73605666
64MAP3K10.73313108
65RET0.70037458
66TESK20.68286401
67RAF10.67887750
68MAP2K60.67249032
69CAMK1G0.66136764
70PDPK10.65736827
71LRRK20.64137001
72FYN0.63241171
73IRAK10.62965403
74TLK10.61446024
75CCNB10.60048055
76MAP3K140.56971102
77NUAK10.56511096
78BMX0.54841368
79YES10.54557965
80TTK0.54250266
81MAP3K30.53833577
82GRK70.53414323
83MAPK120.52362202
84RPS6KA40.51737144
85RPS6KC10.51270033
86RPS6KL10.51270033
87EEF2K0.51150842
88MAPKAPK20.50940899
89STK110.48433886
90TRIB30.48373586
91MAP2K40.47860666
92DAPK20.46625578
93CHEK20.44768909
94RPS6KA60.44469759
95PRKD20.44062812
96PKN20.43388670
97RPS6KA20.42688872
98SIK20.42607467
99PINK10.41965701
100CHEK10.40577348
101FGFR40.39885550
102BCR0.38764866
103CDK120.38394119
104CDC70.36550966
105FGFR30.36352197
106STK100.35393651
107PAK40.33032554
108IRAK20.32513195
109STK38L0.31954896
110ATM0.31497553
111BMPR1B0.30864698
112TAOK20.30642091
113PTK60.30185957
114ADRBK20.29618790
115WEE10.29499916
116PRKD10.27752643
117ATR0.26737522
118PAK10.25635195
119MAPKAPK50.24975735
120MUSK0.24640477
121LMTK20.22093979
122PLK40.20242211
123PAK20.19877705
124NLK0.19168300
125CAMKK10.19106161
126PRKCG0.18289449
127MARK20.18265731
128RPS6KB10.17906020
129MTOR0.17511714
130NEK60.16682386
131MAP3K100.15416861
132RIPK10.15253623
133PLK10.14394298
134PRKCZ0.13562750
135RPS6KA10.12982278
136PDGFRB0.12874898
137PRKAA10.12350563
138CDC42BPA0.10454970
139CSK0.09357799
140CLK10.09234477
141ZAP700.08733470
142EGFR0.08482513
143PRKG20.07664872
144BRSK20.07638236
145TAOK10.07611653
146MATK0.06503831
147PRKCD0.06498797
148PRKCQ0.05944699
149CDK40.05357324
150PRKACG0.04422126
151PRKG10.04125122
152EPHB10.03853499
153MAP4K10.03741769
154GSK3B0.03243673
155MAP2K20.02776826
156MARK10.02662601
157MAP3K50.02532672
158MARK30.01965705
159DAPK10.01886648
160MAPK80.01170659
161CDK150.00948895
162CDK10.00917458
163CSNK2A10.00714287
164PIM10.00671865
165PRKDC0.00595549
166PKN10.00468102
167CDK20.00366436
168PRKCB0.00357280
169LATS10.00166199
170PIK3CG-0.0039158

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.42117547
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34634547
3Vitamin B6 metabolism_Homo sapiens_hsa007503.82190760
4Pyruvate metabolism_Homo sapiens_hsa006203.50065764
5Primary immunodeficiency_Homo sapiens_hsa053403.15760453
6Linoleic acid metabolism_Homo sapiens_hsa005912.97581837
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.97228179
8Leishmaniasis_Homo sapiens_hsa051402.72680205
9Dorso-ventral axis formation_Homo sapiens_hsa043202.68817466
10Glucagon signaling pathway_Homo sapiens_hsa049222.68306245
11Propanoate metabolism_Homo sapiens_hsa006402.39691254
12Basal transcription factors_Homo sapiens_hsa030222.38610609
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.27625324
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.23064604
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08169987
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02651622
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98286624
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93215971
19Glycerolipid metabolism_Homo sapiens_hsa005611.88298523
20Hematopoietic cell lineage_Homo sapiens_hsa046401.88041045
21Selenocompound metabolism_Homo sapiens_hsa004501.87460526
22Chemokine signaling pathway_Homo sapiens_hsa040621.84884322
23Acute myeloid leukemia_Homo sapiens_hsa052211.80767685
24Malaria_Homo sapiens_hsa051441.79527887
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76646100
26Pentose phosphate pathway_Homo sapiens_hsa000301.76346762
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76187462
28Oocyte meiosis_Homo sapiens_hsa041141.71499898
29Tuberculosis_Homo sapiens_hsa051521.70859706
30Fanconi anemia pathway_Homo sapiens_hsa034601.69553821
31Staphylococcus aureus infection_Homo sapiens_hsa051501.68217058
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67570200
33PPAR signaling pathway_Homo sapiens_hsa033201.66784595
34Collecting duct acid secretion_Homo sapiens_hsa049661.63952127
35Platelet activation_Homo sapiens_hsa046111.63182623
36Allograft rejection_Homo sapiens_hsa053301.59590424
37TNF signaling pathway_Homo sapiens_hsa046681.57859716
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.56497214
39Ether lipid metabolism_Homo sapiens_hsa005651.56165475
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54186132
41Legionellosis_Homo sapiens_hsa051341.50596886
42Amphetamine addiction_Homo sapiens_hsa050311.48947137
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.48215800
44Non-small cell lung cancer_Homo sapiens_hsa052231.46808348
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46488811
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45049286
47Shigellosis_Homo sapiens_hsa051311.43633809
48Autoimmune thyroid disease_Homo sapiens_hsa053201.43005366
49African trypanosomiasis_Homo sapiens_hsa051431.40788751
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.40162012
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.39386361
52Fructose and mannose metabolism_Homo sapiens_hsa000511.38413099
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.37054800
54Mineral absorption_Homo sapiens_hsa049781.34120864
55Antigen processing and presentation_Homo sapiens_hsa046121.33751562
56Hepatitis B_Homo sapiens_hsa051611.29223460
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27861195
58Herpes simplex infection_Homo sapiens_hsa051681.27715897
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26939585
60Apoptosis_Homo sapiens_hsa042101.26791107
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25099976
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.22675809
63Cardiac muscle contraction_Homo sapiens_hsa042601.16241332
64Huntingtons disease_Homo sapiens_hsa050161.12346466
65Type I diabetes mellitus_Homo sapiens_hsa049401.08664660
66SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06803019
67Fat digestion and absorption_Homo sapiens_hsa049751.04430521
68Viral myocarditis_Homo sapiens_hsa054161.04125750
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03169593
70mRNA surveillance pathway_Homo sapiens_hsa030151.00764261
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99350720
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99149063
73Hedgehog signaling pathway_Homo sapiens_hsa043400.98802358
74Carbon metabolism_Homo sapiens_hsa012000.98002815
75Pancreatic cancer_Homo sapiens_hsa052120.97094614
76Fatty acid metabolism_Homo sapiens_hsa012120.95165064
77RNA transport_Homo sapiens_hsa030130.94367250
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92469606
79Renin secretion_Homo sapiens_hsa049240.87307573
80Purine metabolism_Homo sapiens_hsa002300.85382832
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.84321316
82Pertussis_Homo sapiens_hsa051330.82890509
83Chronic myeloid leukemia_Homo sapiens_hsa052200.82091213
84Fatty acid degradation_Homo sapiens_hsa000710.81903272
85Prolactin signaling pathway_Homo sapiens_hsa049170.81857254
86Hepatitis C_Homo sapiens_hsa051600.81160336
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.79936319
88Arachidonic acid metabolism_Homo sapiens_hsa005900.79219947
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.77695903
90ABC transporters_Homo sapiens_hsa020100.76710244
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76626477
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73929271
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71897642
94Long-term potentiation_Homo sapiens_hsa047200.68441373
95Colorectal cancer_Homo sapiens_hsa052100.68169880
96VEGF signaling pathway_Homo sapiens_hsa043700.66561824
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.65488600
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.65073634
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64628555
100Glutathione metabolism_Homo sapiens_hsa004800.64453518
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63958143
102Rap1 signaling pathway_Homo sapiens_hsa040150.60412645
103Notch signaling pathway_Homo sapiens_hsa043300.60188067
104Choline metabolism in cancer_Homo sapiens_hsa052310.59645194
105Estrogen signaling pathway_Homo sapiens_hsa049150.59463676
106B cell receptor signaling pathway_Homo sapiens_hsa046620.58419995
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56839620
108Lysosome_Homo sapiens_hsa041420.56571086
109Endometrial cancer_Homo sapiens_hsa052130.56147907
110Renin-angiotensin system_Homo sapiens_hsa046140.55171148
111Systemic lupus erythematosus_Homo sapiens_hsa053220.55003120
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.54558237
113Osteoclast differentiation_Homo sapiens_hsa043800.53650921
114Synaptic vesicle cycle_Homo sapiens_hsa047210.53478123
115Amoebiasis_Homo sapiens_hsa051460.52751459
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52384592
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51325941
118Salmonella infection_Homo sapiens_hsa051320.49644170
119Calcium signaling pathway_Homo sapiens_hsa040200.48448646
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48374154
121Chemical carcinogenesis_Homo sapiens_hsa052040.47361513
122Insulin secretion_Homo sapiens_hsa049110.46936997
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46481201
124HTLV-I infection_Homo sapiens_hsa051660.46108257
125Endocytosis_Homo sapiens_hsa041440.45949590
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45853057
127Measles_Homo sapiens_hsa051620.45460106
128Mismatch repair_Homo sapiens_hsa034300.44793309
129Toxoplasmosis_Homo sapiens_hsa051450.44545979
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43825652
131Renal cell carcinoma_Homo sapiens_hsa052110.43308716
132Rheumatoid arthritis_Homo sapiens_hsa053230.41722150
133Epstein-Barr virus infection_Homo sapiens_hsa051690.41166425
134mTOR signaling pathway_Homo sapiens_hsa041500.39928782
135Inositol phosphate metabolism_Homo sapiens_hsa005620.39792451
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39700888
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39343422
138Biosynthesis of amino acids_Homo sapiens_hsa012300.39012630
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38690878
140MAPK signaling pathway_Homo sapiens_hsa040100.38102547
141FoxO signaling pathway_Homo sapiens_hsa040680.37676817
142Glioma_Homo sapiens_hsa052140.37455831
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35815368
144Phagosome_Homo sapiens_hsa041450.35493954
145Asthma_Homo sapiens_hsa053100.35031085
146Insulin resistance_Homo sapiens_hsa049310.34848409
147Thyroid hormone synthesis_Homo sapiens_hsa049180.34529224
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.33946206
149Influenza A_Homo sapiens_hsa051640.33123434
150Basal cell carcinoma_Homo sapiens_hsa052170.33093523
151HIF-1 signaling pathway_Homo sapiens_hsa040660.31536815
152Cholinergic synapse_Homo sapiens_hsa047250.31251409
153Pancreatic secretion_Homo sapiens_hsa049720.29537422
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27560021
155Bile secretion_Homo sapiens_hsa049760.26951223
156ErbB signaling pathway_Homo sapiens_hsa040120.26577621
157Viral carcinogenesis_Homo sapiens_hsa052030.26381566
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26155556
159Ras signaling pathway_Homo sapiens_hsa040140.26129724
160Protein digestion and absorption_Homo sapiens_hsa049740.25919878
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25816458
162T cell receptor signaling pathway_Homo sapiens_hsa046600.23815391
163NF-kappa B signaling pathway_Homo sapiens_hsa040640.23400738
164Metabolic pathways_Homo sapiens_hsa011000.23018170
165AMPK signaling pathway_Homo sapiens_hsa041520.21175100
166Wnt signaling pathway_Homo sapiens_hsa043100.21105234
167Alcoholism_Homo sapiens_hsa050340.21100687
168Sphingolipid metabolism_Homo sapiens_hsa006000.20782302
169Graft-versus-host disease_Homo sapiens_hsa053320.18821780
170cAMP signaling pathway_Homo sapiens_hsa040240.18739738
171Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18530773
172Salivary secretion_Homo sapiens_hsa049700.17827357

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