CMTM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.97317039
2negative regulation of cell killing (GO:0031342)6.40555281
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.40555281
4positive regulation by symbiont of host defense response (GO:0052509)5.92782546
5modulation by symbiont of host defense response (GO:0052031)5.92782546
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.92782546
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.92782546
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.92782546
9modulation by symbiont of host immune response (GO:0052553)5.92782546
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.72873171
11neutrophil activation involved in immune response (GO:0002283)5.66936062
12antigen processing and presentation of endogenous antigen (GO:0019883)5.51777564
13leukocyte migration involved in inflammatory response (GO:0002523)5.35172531
14detection of other organism (GO:0098543)5.25590188
15positive regulation of gamma-delta T cell activation (GO:0046645)5.18643015
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04424071
17detection of bacterium (GO:0016045)4.96410602
18macrophage activation involved in immune response (GO:0002281)4.83600424
19detection of molecule of bacterial origin (GO:0032490)4.81991188
20regulation of B cell receptor signaling pathway (GO:0050855)4.79674626
21detection of external biotic stimulus (GO:0098581)4.69773506
22neutrophil activation (GO:0042119)4.64488796
23leukocyte aggregation (GO:0070486)4.64353395
24response to peptidoglycan (GO:0032494)4.62100054
25cellular extravasation (GO:0045123)4.52004669
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.49565337
27response to interleukin-15 (GO:0070672)4.31888225
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.26842489
29respiratory burst (GO:0045730)4.24719774
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.18997228
31microglial cell activation (GO:0001774)4.12799800
32detection of biotic stimulus (GO:0009595)4.11177592
33granulocyte activation (GO:0036230)4.10285953
34negative regulation of interleukin-12 production (GO:0032695)4.08165756
35regulation of interferon-beta biosynthetic process (GO:0045357)4.06575159
36response to host immune response (GO:0052572)4.02481827
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.02481827
38cellular response to interleukin-15 (GO:0071350)4.01589744
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.99747244
40regulation of mast cell degranulation (GO:0043304)3.98979035
41neutrophil mediated immunity (GO:0002446)3.91126673
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.84319583
43negative regulation of leukocyte mediated immunity (GO:0002704)3.75859310
44regulation of myeloid leukocyte mediated immunity (GO:0002886)3.74436092
45myeloid cell activation involved in immune response (GO:0002275)3.74240492
46regulation of gamma-delta T cell activation (GO:0046643)3.73384365
47macrophage activation (GO:0042116)3.69259433
48regulation of mast cell activation involved in immune response (GO:0033006)3.69149935
49immunoglobulin mediated immune response (GO:0016064)3.66818211
50response to host defenses (GO:0052200)3.64948587
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.64948587
52response to host (GO:0075136)3.64948587
53production of molecular mediator involved in inflammatory response (GO:0002532)3.63847523
54negative regulation of phagocytosis (GO:0050765)3.55932586
55antigen processing and presentation via MHC class Ib (GO:0002475)3.49435344
56regulation of leukocyte degranulation (GO:0043300)3.48315309
57leukocyte degranulation (GO:0043299)3.45885041
58positive regulation of mast cell activation (GO:0033005)3.45685695
59regulation of mast cell activation (GO:0033003)3.42720902
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.36590986
61positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34491681
62myeloid leukocyte mediated immunity (GO:0002444)3.33308000
63negative regulation of T cell mediated immunity (GO:0002710)3.29304811
64regulation of gamma-delta T cell differentiation (GO:0045586)3.29256575
65B cell receptor signaling pathway (GO:0050853)3.25756810
66regulation of T-helper 2 cell differentiation (GO:0045628)3.24813522
67regulation of T cell mediated cytotoxicity (GO:0001914)3.20764078
68type I interferon signaling pathway (GO:0060337)3.19410068
69cellular response to type I interferon (GO:0071357)3.19410068
70response to type I interferon (GO:0034340)3.18710631
71dendritic cell chemotaxis (GO:0002407)3.10403613
72dendritic cell migration (GO:0036336)3.09225762
73regulation of regulated secretory pathway (GO:1903305)3.08942097
74negative regulation of T-helper cell differentiation (GO:0045623)3.08866789
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08866789
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07504951
77regulation of tolerance induction (GO:0002643)3.06453276
78regulation of B cell differentiation (GO:0045577)3.04601510
79germinal center formation (GO:0002467)3.02721005
80B cell mediated immunity (GO:0019724)2.98605034
81neutrophil chemotaxis (GO:0030593)2.98454904
82regulation of T cell tolerance induction (GO:0002664)2.98090504
83regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97120626
84neutrophil migration (GO:1990266)2.90757116
85defense response to protozoan (GO:0042832)2.89179051
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88115583
87regulation of natural killer cell mediated immunity (GO:0002715)2.88115583
88negative regulation of interleukin-6 production (GO:0032715)2.87958666
89relaxation of smooth muscle (GO:0044557)2.84524763
90positive regulation of mast cell degranulation (GO:0043306)2.83918647
91positive regulation of mast cell activation involved in immune response (GO:0033008)2.83918647
92regulation of phosphoprotein phosphatase activity (GO:0043666)2.83503997
93myeloid leukocyte activation (GO:0002274)2.80963875
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77997023
95regulation of platelet aggregation (GO:0090330)2.77952161
96positive regulation of B cell differentiation (GO:0045579)2.77491328
97negative regulation of alpha-beta T cell activation (GO:0046636)2.76818973
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76668129
99regulation of regulatory T cell differentiation (GO:0045589)2.75349393
100negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74759872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.80808376
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.74995505
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.34402214
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33081047
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14114187
6SPI1_23127762_ChIP-Seq_K562_Human2.80885009
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72523155
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71737182
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.65937873
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64552888
11SPI1_23547873_ChIP-Seq_NB4_Human2.57792618
12RUNX_20019798_ChIP-Seq_JUKART_Human2.54183910
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46387315
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46108077
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45823135
16VDR_24763502_ChIP-Seq_THP-1_Human2.34780798
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27863310
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26152258
19SCL_19346495_ChIP-Seq_HPC-7_Human2.24091320
20VDR_21846776_ChIP-Seq_THP-1_Human2.22721841
21UTX_26944678_Chip-Seq_JUKART_Human2.14646149
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14042831
23MYB_26560356_Chip-Seq_TH2_Human2.10993752
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08575219
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04604476
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.03401983
27MAF_26560356_Chip-Seq_TH1_Human1.99748816
28MYB_26560356_Chip-Seq_TH1_Human1.99172445
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91420795
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.89488699
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88740803
32* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.85130509
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78599269
34MAF_26560356_Chip-Seq_TH2_Human1.77478956
35KDM2B_26808549_Chip-Seq_DND41_Human1.70950442
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70299474
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68299382
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.67491434
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66934536
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66297360
41GATA3_27048872_Chip-Seq_THYMUS_Human1.66055921
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65420618
43VDR_24787735_ChIP-Seq_THP-1_Human1.64267284
44TCF7_22412390_ChIP-Seq_EML_Mouse1.62250073
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48227788
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48124709
47GATA1_22025678_ChIP-Seq_K562_Human1.47985712
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42664630
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42647826
50GATA3_26560356_Chip-Seq_TH2_Human1.41555168
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40919669
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.40284138
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40127409
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36739817
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.36549742
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35195830
57MYC_22102868_ChIP-Seq_BL_Human1.34574904
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33023361
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.31349553
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30128762
61LXR_22292898_ChIP-Seq_THP-1_Human1.29935101
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28184835
63* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24726110
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23663337
65SPI1_20517297_ChIP-Seq_HL60_Human1.21018802
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20870083
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20686948
68GATA1_19941826_ChIP-Seq_K562_Human1.18302275
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17741677
70* BCL6_27268052_Chip-Seq_Bcells_Human1.16397521
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15377726
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14543338
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14462145
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13723220
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13531724
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12792629
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.12749429
78BCOR_27268052_Chip-Seq_Bcells_Human1.09572009
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08827905
80NANOG_20526341_ChIP-Seq_ESCs_Human1.03631570
81GATA2_19941826_ChIP-Seq_K562_Human1.02940769
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99903141
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.98742733
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97794071
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96615146
86SMC4_20622854_ChIP-Seq_HELA_Human0.92643407
87PU_27001747_Chip-Seq_BMDM_Mouse0.91603161
88EGR1_19374776_ChIP-ChIP_THP-1_Human0.90252583
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88776154
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87234665
91* P300_27268052_Chip-Seq_Bcells_Human0.85307171
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85045590
93RAC3_21632823_ChIP-Seq_H3396_Human0.84884879
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81887613
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81613710
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81518219
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80504357
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79209700
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78987137
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.78898997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.84983810
2MP0003436_decreased_susceptibility_to4.19882438
3MP0001835_abnormal_antigen_presentation3.56490770
4MP0003303_peritoneal_inflammation3.54711768
5MP0002419_abnormal_innate_immunity3.12501939
6MP0008004_abnormal_stomach_pH3.05700418
7MP0002132_abnormal_respiratory_system3.03039779
8MP0009785_altered_susceptibility_to2.87487634
9MP0005025_abnormal_response_to2.83464711
10MP0001800_abnormal_humoral_immune2.72618080
11MP0005671_abnormal_response_to2.68293405
12MP0005000_abnormal_immune_tolerance2.62842466
13MP0005410_abnormal_fertilization2.59260738
14MP0005464_abnormal_platelet_physiology2.57014425
15MP0000685_abnormal_immune_system2.56878765
16MP0001790_abnormal_immune_system2.50620394
17MP0005387_immune_system_phenotype2.50620394
18MP0002723_abnormal_immune_serum2.49968406
19MP0002420_abnormal_adaptive_immunity2.49009739
20MP0001819_abnormal_immune_cell2.45895074
21MP0000465_gastrointestinal_hemorrhage2.38456727
22MP0002452_abnormal_antigen_presenting2.32934241
23MP0001533_abnormal_skeleton_physiology2.14921504
24MP0006082_CNS_inflammation2.10296734
25MP0003191_abnormal_cellular_cholesterol2.09566407
26MP0002148_abnormal_hypersensitivity_rea2.08680208
27MP0003300_gastrointestinal_ulcer2.03974475
28MP0003763_abnormal_thymus_physiology1.95905694
29MP0003828_pulmonary_edema1.94110469
30MP0002405_respiratory_system_inflammati1.91556282
31MP0002398_abnormal_bone_marrow1.89291029
32MP0002277_abnormal_respiratory_mucosa1.86937646
33MP0000716_abnormal_immune_system1.81920415
34MP0008260_abnormal_autophagy1.77979814
35MP0004381_abnormal_hair_follicle1.76164269
36MP0010155_abnormal_intestine_physiology1.73904437
37MP0009278_abnormal_bone_marrow1.69150264
38MP0001845_abnormal_inflammatory_respons1.67448980
39MP0003866_abnormal_defecation1.60094320
40MP0003045_fibrosis1.56095382
41MP0002722_abnormal_immune_system1.52084908
42MP0005451_abnormal_body_composition1.48917927
43MP0004883_abnormal_blood_vessel1.47441538
44MP0009764_decreased_sensitivity_to1.46321805
45MP0000689_abnormal_spleen_morphology1.45340161
46MP0002429_abnormal_blood_cell1.43551124
47MP0005058_abnormal_lysosome_morphology1.41452813
48MP0004947_skin_inflammation1.41213512
49MP0000703_abnormal_thymus_morphology1.39795389
50MP0003183_abnormal_peptide_metabolism1.38698360
51MP0002396_abnormal_hematopoietic_system1.35274847
52MP0008469_abnormal_protein_level1.30854127
53MP0005397_hematopoietic_system_phenotyp1.29137016
54MP0001545_abnormal_hematopoietic_system1.29137016
55MP0002998_abnormal_bone_remodeling1.28595893
56MP0000343_altered_response_to1.24812931
57MP0003075_altered_response_to1.24148121
58MP0003172_abnormal_lysosome_physiology1.22447853
59MP0000858_altered_metastatic_potential1.18223824
60MP0005164_abnormal_response_to1.18222457
61MP0009333_abnormal_splenocyte_physiolog1.17267309
62MP0001851_eye_inflammation1.15986688
63MP0004510_myositis1.11993129
64MP0005166_decreased_susceptibility_to1.09516882
65MP0005310_abnormal_salivary_gland0.95763337
66MP0003806_abnormal_nucleotide_metabolis0.95198212
67MP0003315_abnormal_perineum_morphology0.93676504
68MP0005377_hearing/vestibular/ear_phenot0.93389766
69MP0003878_abnormal_ear_physiology0.93389766
70MP0005248_abnormal_Harderian_gland0.86257214
71MP0000490_abnormal_crypts_of0.79954230
72MP0005390_skeleton_phenotype0.79268606
73MP0000015_abnormal_ear_pigmentation0.77088401
74MP0009763_increased_sensitivity_to0.74288796
75MP0001663_abnormal_digestive_system0.74048038
76MP0003690_abnormal_glial_cell0.73166967
77MP0003795_abnormal_bone_structure0.71843905
78MP0008874_decreased_physiological_sensi0.71095636
79MP0005083_abnormal_biliary_tract0.66803752
80MP0002166_altered_tumor_susceptibility0.65918723
81MP0003448_altered_tumor_morphology0.65532393
82MP0009765_abnormal_xenobiotic_induced0.63230038
83MP0004484_altered_response_of0.60777556
84MP0000249_abnormal_blood_vessel0.59920683
85MP0000470_abnormal_stomach_morphology0.58912028
86MP0003698_abnormal_male_reproductive0.58590056
87MP0004130_abnormal_muscle_cell0.57958347
88MP0002138_abnormal_hepatobiliary_system0.56112301
89MP0002133_abnormal_respiratory_system0.55969433
90MP0005388_respiratory_system_phenotype0.55969433
91MP0001664_abnormal_digestion0.55422496
92MP0001986_abnormal_taste_sensitivity0.55415332
93MP0005075_abnormal_melanosome_morpholog0.54682212
94MP0004808_abnormal_hematopoietic_stem0.54575780
95MP0005319_abnormal_enzyme/_coenzyme0.50888608
96MP0001849_ear_inflammation0.49166416
97MP0002653_abnormal_ependyma_morphology0.47578793
98MP0005167_abnormal_blood-brain_barrier0.47319912
99MP0001929_abnormal_gametogenesis0.47259632
100MP0005647_abnormal_sex_gland0.46944982

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.74142646
2Myositis (HP:0100614)6.00256981
3Recurrent abscess formation (HP:0002722)5.87911782
4Orchitis (HP:0100796)5.81431539
5Recurrent bacterial skin infections (HP:0005406)5.63991315
6Retrobulbar optic neuritis (HP:0100654)5.50035927
7Optic neuritis (HP:0100653)5.50035927
8Abnormality of macrophages (HP:0004311)5.25197719
9Stomatitis (HP:0010280)5.04647292
10Recurrent gram-negative bacterial infections (HP:0005420)4.94555857
11Chronic obstructive pulmonary disease (HP:0006510)4.47751683
12Obstructive lung disease (HP:0006536)4.47751683
13Gastrointestinal infarctions (HP:0005244)4.42065082
14Elevated erythrocyte sedimentation rate (HP:0003565)4.38142932
15Prolonged bleeding time (HP:0003010)4.37931360
16Hypochromic microcytic anemia (HP:0004840)4.13125814
17Keratoconjunctivitis sicca (HP:0001097)4.03990770
18Recurrent fungal infections (HP:0002841)3.94794474
19Meningitis (HP:0001287)3.93421371
20Spontaneous hematomas (HP:0007420)3.87359031
21Mediastinal lymphadenopathy (HP:0100721)3.84427280
22Encephalitis (HP:0002383)3.79841372
23Keratoconjunctivitis (HP:0001096)3.73472471
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.62595490
25Recurrent skin infections (HP:0001581)3.60113530
26Inflammation of the large intestine (HP:0002037)3.55389090
27Gingivitis (HP:0000230)3.50356584
28Increased IgE level (HP:0003212)3.44230300
29Urticaria (HP:0001025)3.42911970
30Gastrointestinal inflammation (HP:0004386)3.40239401
31Vasculitis (HP:0002633)3.38604884
32Hypochromic anemia (HP:0001931)3.37255979
33Gingival bleeding (HP:0000225)3.26239268
34Epistaxis (HP:0000421)3.24346971
35Colitis (HP:0002583)3.21139835
36Episodic fever (HP:0001954)3.15468167
37Petechiae (HP:0000967)3.15348424
38Recurrent cutaneous fungal infections (HP:0011370)3.14547549
39Chronic mucocutaneous candidiasis (HP:0002728)3.14547549
40Chest pain (HP:0100749)3.11613012
41Cellulitis (HP:0100658)3.06277092
42Resting tremor (HP:0002322)3.03411611
43Arterial thrombosis (HP:0004420)3.02080145
44Peritonitis (HP:0002586)2.99109720
45Hemoptysis (HP:0002105)2.87739978
46Ventricular fibrillation (HP:0001663)2.85142488
47Abnormal platelet volume (HP:0011876)2.81752792
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79923712
49Pulmonary embolism (HP:0002204)2.79567587
50Anorexia (HP:0002039)2.74608312
51Leukocytosis (HP:0001974)2.71576015
52Pulmonary infiltrates (HP:0002113)2.68382991
53Purpura (HP:0000979)2.65679963
54Nasal polyposis (HP:0100582)2.65586974
55T lymphocytopenia (HP:0005403)2.65332456
56Abnormality of T cell number (HP:0011839)2.56941974
57Microcytic anemia (HP:0001935)2.55638031
58Granulocytopenia (HP:0001913)2.50459889
59Osteomyelitis (HP:0002754)2.46387111
60Increased IgM level (HP:0003496)2.43752765
61Abnormality of T cells (HP:0002843)2.34704074
62Menorrhagia (HP:0000132)2.34119880
63Postural instability (HP:0002172)2.33475769
64Gangrene (HP:0100758)2.32509522
65Panhypogammaglobulinemia (HP:0003139)2.32326013
66Amyloidosis (HP:0011034)2.32077257
67Abnormality of the columella (HP:0009929)2.28365858
68Polyneuropathy (HP:0001271)2.27900314
69Sepsis (HP:0100806)2.26676863
70Pustule (HP:0200039)2.22667814
71Abnormality of the pleura (HP:0002103)2.21175128
72Abnormality of the nasal mucosa (HP:0000433)2.19869362
73Recurrent viral infections (HP:0004429)2.19716500
74Abnormal sex determination (HP:0012244)2.18840105
75Sex reversal (HP:0012245)2.18840105
76Eosinophilia (HP:0001880)2.15634585
77Glomerulopathy (HP:0100820)2.13457862
78Acute hepatic failure (HP:0006554)2.10780208
79Abnormality of the endocardium (HP:0004306)2.07776649
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.07528516
81Vertigo (HP:0002321)2.06427270
82Hepatosplenomegaly (HP:0001433)2.06241527
83Chronic otitis media (HP:0000389)2.05897884
84Lymphopenia (HP:0001888)2.03784540
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02368108
86Absent/shortened dynein arms (HP:0200106)2.01898086
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.01898086
88Keratitis (HP:0000491)2.01869670
89Abnormality of the peritoneum (HP:0002585)2.01099034
90Difficulty running (HP:0009046)1.98174985
91Abnormality of T cell physiology (HP:0011840)1.97449672
92Recurrent pneumonia (HP:0006532)1.93828784
93Hypergammaglobulinemia (HP:0010702)1.93398474
94Recurrent sinusitis (HP:0011108)1.93211519
95Skin ulcer (HP:0200042)1.93078827
96Acne (HP:0001061)1.92638226
97Increased mean platelet volume (HP:0011877)1.90565259
98Abnormality of cells of the lymphoid lineage (HP:0012140)1.90093023
99Abnormality of the pericardium (HP:0001697)1.83089346
100Premature loss of primary teeth (HP:0006323)1.77668667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.82525675
2PINK14.29524987
3MARK33.40225210
4IRAK43.23156734
5MAP4K13.09827076
6BLK2.83063187
7MAP2K32.80951082
8FES2.63161007
9GRK62.60056171
10CSK2.58722048
11ERN12.46151634
12TNK22.37881429
13EPHB12.34524031
14TYK22.24476476
15TAOK12.01150539
16BTK1.98071034
17FGR1.97380734
18ZAP701.90034077
19HCK1.86050837
20MAP3K31.81878239
21MAP3K11.53235244
22SYK1.52228736
23KSR21.49164588
24MAP3K111.48693991
25JAK21.43428550
26TXK1.42788965
27JAK31.40992242
28LYN1.30256745
29PRPF4B1.27446672
30STK381.23568489
31MAP3K131.13720492
32YES11.11024972
33IKBKE1.04976094
34PTK2B1.04199025
35TLK11.04069825
36TAOK31.01948142
37SIK30.99194384
38IRAK20.96682603
39CSF1R0.95860621
40PDK10.95125321
41LCK0.94706258
42MARK20.94603719
43KIT0.92992577
44JAK10.92180657
45PDPK10.90805206
46PTK60.87901188
47TBK10.87697757
48MAP3K140.87364599
49IRAK10.84959491
50ITK0.83282965
51MYLK0.81759542
52PRKCQ0.81447667
53MAP3K50.81194059
54DYRK30.77941053
55RPS6KA50.77672677
56TEC0.76183166
57MAP3K20.75722406
58MATK0.72004198
59PRKD20.71163873
60TESK20.69302453
61CDK190.69021864
62TAOK20.67817400
63SIK20.67787573
64RET0.67524819
65CDC42BPA0.64478205
66MAPK120.64205726
67TRIB30.63500470
68RAF10.62159956
69LRRK20.60634861
70MAP3K60.60564742
71PIK3CG0.59808545
72PRKG20.59530702
73DYRK1B0.58658773
74FYN0.58501168
75MAP2K40.55247736
76STK110.53123662
77BMPR20.51994552
78STK100.50814306
79IKBKB0.50782887
80SGK30.49415846
81SGK4940.46025852
82SGK2230.46025852
83MAP3K70.42990011
84EPHA30.42446024
85NLK0.40965832
86SMG10.40368164
87FGFR30.40054161
88SGK20.39461135
89PIM10.38485707
90TGFBR20.37593133
91KSR10.36385139
92DAPK20.35233083
93MAP2K60.32980044
94MAPKAPK20.32264507
95HIPK20.31995698
96RPS6KL10.31073562
97RPS6KC10.31073562
98PAK10.29331848
99PRKCZ0.28355044
100PKN20.27595355

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.03558315
2Osteoclast differentiation_Homo sapiens_hsa043802.93672150
3Leishmaniasis_Homo sapiens_hsa051402.75108576
4Staphylococcus aureus infection_Homo sapiens_hsa051502.61959623
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.45706619
6B cell receptor signaling pathway_Homo sapiens_hsa046622.30534178
7Phagosome_Homo sapiens_hsa041452.26428476
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.09818549
9Tuberculosis_Homo sapiens_hsa051522.06492967
10Graft-versus-host disease_Homo sapiens_hsa053322.02146373
11Malaria_Homo sapiens_hsa051441.94049025
12Allograft rejection_Homo sapiens_hsa053301.90975787
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85651562
14Primary immunodeficiency_Homo sapiens_hsa053401.82449906
15Autoimmune thyroid disease_Homo sapiens_hsa053201.80150590
16Chemokine signaling pathway_Homo sapiens_hsa040621.77057519
17Apoptosis_Homo sapiens_hsa042101.73774715
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67517177
19Measles_Homo sapiens_hsa051621.65724577
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63475169
21T cell receptor signaling pathway_Homo sapiens_hsa046601.62473153
22Acute myeloid leukemia_Homo sapiens_hsa052211.60846811
23Hematopoietic cell lineage_Homo sapiens_hsa046401.57756946
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51851307
25Platelet activation_Homo sapiens_hsa046111.49158462
26Legionellosis_Homo sapiens_hsa051341.49013049
27Gap junction_Homo sapiens_hsa045401.47711536
28Type I diabetes mellitus_Homo sapiens_hsa049401.38963304
29Influenza A_Homo sapiens_hsa051641.34408722
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.33110465
31Antigen processing and presentation_Homo sapiens_hsa046121.32175283
32Toxoplasmosis_Homo sapiens_hsa051451.31236416
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.25660704
34Herpes simplex infection_Homo sapiens_hsa051681.25444679
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.24804946
36Viral myocarditis_Homo sapiens_hsa054161.24629301
37Non-small cell lung cancer_Homo sapiens_hsa052231.24253471
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21567310
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19086786
40African trypanosomiasis_Homo sapiens_hsa051431.07900580
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07539012
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04263801
43TNF signaling pathway_Homo sapiens_hsa046681.01199404
44Hepatitis B_Homo sapiens_hsa051611.00022240
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96904182
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96809742
47VEGF signaling pathway_Homo sapiens_hsa043700.95747868
48Endocytosis_Homo sapiens_hsa041440.95324551
49Hepatitis C_Homo sapiens_hsa051600.88765897
50Dorso-ventral axis formation_Homo sapiens_hsa043200.88023476
51Shigellosis_Homo sapiens_hsa051310.87444073
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87019654
53Systemic lupus erythematosus_Homo sapiens_hsa053220.85350298
54Salmonella infection_Homo sapiens_hsa051320.85165824
55Pancreatic cancer_Homo sapiens_hsa052120.83665914
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83267759
57Endometrial cancer_Homo sapiens_hsa052130.82119724
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80051984
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.77655570
60Chronic myeloid leukemia_Homo sapiens_hsa052200.75527843
61FoxO signaling pathway_Homo sapiens_hsa040680.74708791
62Regulation of autophagy_Homo sapiens_hsa041400.73840452
63Choline metabolism in cancer_Homo sapiens_hsa052310.73599826
64Pertussis_Homo sapiens_hsa051330.73251152
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.71597974
66Viral carcinogenesis_Homo sapiens_hsa052030.71532801
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70348568
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.67696031
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67681523
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66632512
71Prolactin signaling pathway_Homo sapiens_hsa049170.65590254
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.65231205
73Renal cell carcinoma_Homo sapiens_hsa052110.64805813
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63811064
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.62539668
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.62278116
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61936996
78Olfactory transduction_Homo sapiens_hsa047400.60026187
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55582085
80Alcoholism_Homo sapiens_hsa050340.53790740
81MAPK signaling pathway_Homo sapiens_hsa040100.51319756
82Rheumatoid arthritis_Homo sapiens_hsa053230.50969035
83Notch signaling pathway_Homo sapiens_hsa043300.50374684
84Rap1 signaling pathway_Homo sapiens_hsa040150.49720968
85Nitrogen metabolism_Homo sapiens_hsa009100.48459530
86Asthma_Homo sapiens_hsa053100.48453293
87Amoebiasis_Homo sapiens_hsa051460.47985541
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47059040
89Inositol phosphate metabolism_Homo sapiens_hsa005620.45833150
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45665379
91mTOR signaling pathway_Homo sapiens_hsa041500.44608091
92GnRH signaling pathway_Homo sapiens_hsa049120.42553560
93Insulin resistance_Homo sapiens_hsa049310.42508436
94Prostate cancer_Homo sapiens_hsa052150.41679362
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40957326
96Type II diabetes mellitus_Homo sapiens_hsa049300.39570135
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.39552827
98HIF-1 signaling pathway_Homo sapiens_hsa040660.39004946
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38949297
100Estrogen signaling pathway_Homo sapiens_hsa049150.38440516

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