CMTM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.01719505
2Golgi transport vesicle coating (GO:0048200)3.90230014
3COPI coating of Golgi vesicle (GO:0048205)3.90230014
4axonemal dynein complex assembly (GO:0070286)3.86962343
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55599516
6synaptic vesicle maturation (GO:0016188)3.54688020
7apical protein localization (GO:0045176)3.45419915
8layer formation in cerebral cortex (GO:0021819)3.39946296
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.39910268
10locomotory exploration behavior (GO:0035641)3.29632858
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.27187643
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.22904010
13cerebellar granule cell differentiation (GO:0021707)3.15262324
14macroautophagy (GO:0016236)3.11272450
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.08605860
16membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.06481297
17activation of protein kinase A activity (GO:0034199)3.06335680
18sodium ion export (GO:0071436)3.05377599
19establishment of apical/basal cell polarity (GO:0035089)3.02855359
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02113478
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96074833
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.94424725
23vitamin transmembrane transport (GO:0035461)2.93028790
24cilium or flagellum-dependent cell motility (GO:0001539)2.92369142
25regulation of cholesterol homeostasis (GO:2000188)2.90458609
26motile cilium assembly (GO:0044458)2.87162772
27glutamate secretion (GO:0014047)2.86616230
28amino acid import (GO:0043090)2.85928575
29establishment or maintenance of apical/basal cell polarity (GO:0035088)2.85715191
30establishment or maintenance of bipolar cell polarity (GO:0061245)2.85715191
31asymmetric protein localization (GO:0008105)2.85525176
32lysine metabolic process (GO:0006553)2.84669042
33lysine catabolic process (GO:0006554)2.84669042
34proline transport (GO:0015824)2.84551127
35epithelial cell-cell adhesion (GO:0090136)2.84227175
36cerebellar Purkinje cell layer development (GO:0021680)2.83481344
37embryonic retina morphogenesis in camera-type eye (GO:0060059)2.75938726
38alanine transport (GO:0032328)2.75438313
39L-amino acid import (GO:0043092)2.75234223
40positive regulation of nuclease activity (GO:0032075)2.74988383
41regulation of clathrin-mediated endocytosis (GO:2000369)2.74149203
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73340058
43membrane repolarization during action potential (GO:0086011)2.72384597
44cell communication by electrical coupling (GO:0010644)2.72211446
45lung epithelium development (GO:0060428)2.71744977
46cellular potassium ion homeostasis (GO:0030007)2.70883459
47sodium ion homeostasis (GO:0055078)2.65613611
48cilium movement (GO:0003341)2.64633657
49primary alcohol catabolic process (GO:0034310)2.64270745
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61912265
51alpha-linolenic acid metabolic process (GO:0036109)2.59546089
52paraxial mesoderm development (GO:0048339)2.58097970
53intestinal cholesterol absorption (GO:0030299)2.57735292
54insulin-like growth factor receptor signaling pathway (GO:0048009)2.56540838
55intestinal absorption (GO:0050892)2.56524197
56cell communication involved in cardiac conduction (GO:0086065)2.55294731
57positive regulation of fatty acid beta-oxidation (GO:0032000)2.53227925
58planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53120416
59sulfur amino acid catabolic process (GO:0000098)2.52497843
60vesicle coating (GO:0006901)2.52057825
61protein retention in ER lumen (GO:0006621)2.51730458
62regulation of synaptic vesicle exocytosis (GO:2000300)2.50963204
63regulation of fatty acid beta-oxidation (GO:0031998)2.50720708
64dicarboxylic acid biosynthetic process (GO:0043650)2.47945392
65negative regulation of sodium ion transport (GO:0010766)2.47258498
66negative regulation of dendrite morphogenesis (GO:0050774)2.45194129
67cellular protein complex localization (GO:0034629)2.44883856
68glutamate metabolic process (GO:0006536)2.44743301
69multicellular organismal water homeostasis (GO:0050891)2.44591038
70activation of Rac GTPase activity (GO:0032863)2.44027409
71establishment of monopolar cell polarity (GO:0061162)2.42748581
72establishment or maintenance of monopolar cell polarity (GO:0061339)2.42748581
73notochord development (GO:0030903)2.41437298
74tight junction assembly (GO:0070830)2.41226646
75regulation of nuclease activity (GO:0032069)2.40934523
76myelin maintenance (GO:0043217)2.39648070
77endoplasmic reticulum unfolded protein response (GO:0030968)2.39045442
78neurotransmitter secretion (GO:0007269)2.38216847
79cell-cell junction maintenance (GO:0045217)2.37531052
80regulation of neuronal synaptic plasticity (GO:0048168)2.37319782
81cell-cell junction assembly (GO:0007043)2.36996255
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35979507
83vocalization behavior (GO:0071625)2.35487898
84establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35002696
85COPII vesicle coating (GO:0048208)2.34753459
86regulation of cholesterol biosynthetic process (GO:0045540)2.34455114
87proline biosynthetic process (GO:0006561)2.33588376
88vesicle transport along microtubule (GO:0047496)2.33549535
89polarized epithelial cell differentiation (GO:0030859)2.33354840
90cellular modified amino acid catabolic process (GO:0042219)2.32831185
91cysteine metabolic process (GO:0006534)2.32300448
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31951611
93regulation of ARF protein signal transduction (GO:0032012)2.30893818
94positive regulation of synapse maturation (GO:0090129)2.30676428
954-hydroxyproline metabolic process (GO:0019471)2.30629712
96ER-nucleus signaling pathway (GO:0006984)2.30449653
97protein complex localization (GO:0031503)2.29617152
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28867505
99L-phenylalanine catabolic process (GO:0006559)2.28867505
100establishment of nucleus localization (GO:0040023)2.28725355
101cellular response to unfolded protein (GO:0034620)2.28655916
102dendritic spine morphogenesis (GO:0060997)2.28566833
103establishment of planar polarity (GO:0001736)2.28416603
104establishment of tissue polarity (GO:0007164)2.28416603
105L-alpha-amino acid transmembrane transport (GO:1902475)2.28099433
106inner ear receptor cell development (GO:0060119)2.27953574
107negative regulation of hormone biosynthetic process (GO:0032353)2.27127084
108negative regulation of hormone metabolic process (GO:0032351)2.27127084
109neuromuscular process controlling balance (GO:0050885)2.27125747
110regulation of hippo signaling (GO:0035330)2.26246874
111ventricular cardiac muscle cell action potential (GO:0086005)2.25695228
112drug catabolic process (GO:0042737)2.25664052
113positive regulation of glycogen biosynthetic process (GO:0045725)2.25028354
114erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.24553367
115L-phenylalanine metabolic process (GO:0006558)2.24553367
116regulation of heart rate by cardiac conduction (GO:0086091)2.24007819
117phosphate ion transport (GO:0006817)2.23878385
118glomerular epithelial cell development (GO:0072310)2.22866113
119homocysteine metabolic process (GO:0050667)2.22282693
120cellular sodium ion homeostasis (GO:0006883)2.21990224
121membrane repolarization (GO:0086009)2.21972131
122hippo signaling (GO:0035329)2.21663769
123adherens junction assembly (GO:0034333)2.21601651
124dendrite morphogenesis (GO:0048813)2.20543011
125synaptic vesicle exocytosis (GO:0016079)2.20030877
126gap junction assembly (GO:0016264)2.19381126
127positive regulation of fatty acid oxidation (GO:0046321)2.19034414
128receptor recycling (GO:0001881)2.17604636
129potassium ion homeostasis (GO:0055075)2.17446297
130protein targeting to Golgi (GO:0000042)2.17019634
131protein localization to endosome (GO:0036010)2.16950743
132chemosensory behavior (GO:0007635)2.16902922
133regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.16629581
134intestinal epithelial cell development (GO:0060576)2.16453922
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.16137831
136aspartate family amino acid catabolic process (GO:0009068)2.15924032
137embryonic foregut morphogenesis (GO:0048617)2.15073816
138plasma membrane repair (GO:0001778)2.14640316
139gamma-aminobutyric acid transport (GO:0015812)2.11936570
140biotin metabolic process (GO:0006768)2.11525902
141innervation (GO:0060384)2.10991967
142positive regulation of glycolytic process (GO:0045821)2.10494773
143glycine transport (GO:0015816)2.09630758
144regulation of steroid hormone biosynthetic process (GO:0090030)2.09329356
145establishment of protein localization to Golgi (GO:0072600)2.08202688
146ethanol metabolic process (GO:0006067)2.07959853
147cellular response to topologically incorrect protein (GO:0035967)2.07934911
148positive regulation of glucose transport (GO:0010828)2.07802770
149neuron remodeling (GO:0016322)2.07604835
150drug transmembrane transport (GO:0006855)2.06766976
151mating behavior (GO:0007617)2.06430770
152positive regulation of glucose import (GO:0046326)2.06013169
153phosphate ion transmembrane transport (GO:0035435)2.05643990
154positive regulation of dendritic spine morphogenesis (GO:0061003)2.05614085
155glial cell proliferation (GO:0014009)2.05513571
156peptidyl-tyrosine autophosphorylation (GO:0038083)2.05069059
157regulation of synaptic vesicle transport (GO:1902803)2.04948004
158regulation of water loss via skin (GO:0033561)2.04722145
159potassium ion import (GO:0010107)2.04487533
160negative regulation of keratinocyte proliferation (GO:0010839)2.04360944
161phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.04095279
162cell junction maintenance (GO:0034331)2.03972319
163sperm capacitation (GO:0048240)2.03872059
164hemidesmosome assembly (GO:0031581)2.03722615
165cell-substrate adherens junction assembly (GO:0007045)2.03083202
166focal adhesion assembly (GO:0048041)2.03083202
167ephrin receptor signaling pathway (GO:0048013)2.02922902
168water homeostasis (GO:0030104)2.02478043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.11333351
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83118451
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53867307
4AR_21909140_ChIP-Seq_LNCAP_Human2.41176198
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.38360755
6* LXR_22158963_ChIP-Seq_LIVER_Mouse2.21718786
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12317365
8ZNF263_19887448_ChIP-Seq_K562_Human2.10198484
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05487190
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99775981
11DROSHA_22980978_ChIP-Seq_HELA_Human1.96460276
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94990492
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92869777
14EZH2_22144423_ChIP-Seq_EOC_Human1.91372843
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.80950618
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80336190
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.72433891
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.71564146
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70140120
20CLOCK_20551151_ChIP-Seq_293T_Human1.69751120
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68937439
22* KDM2B_26808549_Chip-Seq_K562_Human1.67127678
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66246077
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62124304
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61867167
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60278282
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57395833
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.56283278
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55956750
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55577587
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54246929
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53786081
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53575118
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52092384
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49488125
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45904645
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45904645
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44045680
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43828820
40* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39798005
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39679452
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.37537175
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37421313
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36986687
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35741104
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34914162
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34333226
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.31729609
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29922824
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29446164
51REST_21632747_ChIP-Seq_MESCs_Mouse1.29059675
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28082819
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.27769274
54SOX2_20726797_ChIP-Seq_SW620_Human1.27484055
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27462975
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26677383
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25410080
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25326423
59AHR_22903824_ChIP-Seq_MCF-7_Human1.24941749
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.24788914
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24166502
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23595196
63GATA6_25053715_ChIP-Seq_YYC3_Human1.19829297
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.19121852
65ZNF274_21170338_ChIP-Seq_K562_Hela1.18974067
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18361870
67KLF5_25053715_ChIP-Seq_YYC3_Human1.18343653
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.17923929
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15913987
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15761295
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15553893
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15332105
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13198602
74AR_19668381_ChIP-Seq_PC3_Human1.11659952
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.11563018
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.11379880
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10700092
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10631609
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09514231
80* RACK7_27058665_Chip-Seq_MCF-7_Human1.09284716
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09239639
82LXR_22292898_ChIP-Seq_THP-1_Human1.08229546
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08126174
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.07762298
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.07282496
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.06574644
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.06280841
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.06255252
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06065556
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05962552
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.05945970
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05812061
93* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05256101
94* CHD1_26751641_Chip-Seq_LNCaP_Human1.03653953
95RXR_22108803_ChIP-Seq_LS180_Human1.03610400
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03026349
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02603999
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02382333
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02081810
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.01527196
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01446972
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00612931
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00464631
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00139456
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.99099771
106GATA1_26923725_Chip-Seq_HPCs_Mouse0.98936043
107SMC4_20622854_ChIP-Seq_HELA_Human0.98720753
108* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98260777
109SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98225390
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96697898
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96583772
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96251318
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.96144072
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95911885
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95724078
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95475305
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.95168507
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95137154
119* FOXA1_25552417_ChIP-Seq_VCAP_Human0.94569528
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.93721321
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.93721321
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93242574
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93113953
124* EP300_21415370_ChIP-Seq_HL-1_Mouse0.92987573
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92758787
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92709571
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.92663109
128KDM2B_26808549_Chip-Seq_DND41_Human0.92240974
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91909240
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91697123
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91605398
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90834616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.73639385
2MP0003283_abnormal_digestive_organ3.36721179
3MP0002139_abnormal_hepatobiliary_system3.17572568
4MP0004859_abnormal_synaptic_plasticity3.08085541
5MP0009780_abnormal_chondrocyte_physiolo3.04268612
6MP0003705_abnormal_hypodermis_morpholog3.03603204
7MP0000566_synostosis2.97076049
8MP0005360_urolithiasis2.69330147
9MP0005365_abnormal_bile_salt2.54802574
10MP0003252_abnormal_bile_duct2.53972555
11MP0002909_abnormal_adrenal_gland2.46057263
12MP0005085_abnormal_gallbladder_physiolo2.42211228
13MP0005409_darkened_coat_color2.33252180
14MP0010678_abnormal_skin_adnexa2.13599653
15MP0004043_abnormal_pH_regulation2.09119314
16MP0004270_analgesia2.06641377
17MP0002877_abnormal_melanocyte_morpholog2.04274271
18MP0004264_abnormal_extraembryonic_tissu2.04015956
19MP0001666_abnormal_nutrient_absorption2.03890423
20MP0004858_abnormal_nervous_system2.00812453
21MP0000013_abnormal_adipose_tissue1.88764537
22MP0003941_abnormal_skin_development1.80952323
23MP0010329_abnormal_lipoprotein_level1.73734998
24MP0000579_abnormal_nail_morphology1.72149512
25MP0005187_abnormal_penis_morphology1.67822543
26MP0008961_abnormal_basal_metabolism1.64494815
27MP0000383_abnormal_hair_follicle1.63106059
28MP0003635_abnormal_synaptic_transmissio1.61512664
29MP0000537_abnormal_urethra_morphology1.60964918
30MP0002896_abnormal_bone_mineralization1.56708533
31MP0003890_abnormal_embryonic-extraembry1.56603832
32MP0002796_impaired_skin_barrier1.55380310
33MP0008875_abnormal_xenobiotic_pharmacok1.54366212
34MP0003300_gastrointestinal_ulcer1.51495119
35MP0000003_abnormal_adipose_tissue1.51084591
36MP0001944_abnormal_pancreas_morphology1.48624831
37MP0003195_calcinosis1.44456183
38MP0005623_abnormal_meninges_morphology1.38963264
39MP0003868_abnormal_feces_composition1.35871852
40MP0000762_abnormal_tongue_morphology1.32217772
41MP0002098_abnormal_vibrissa_morphology1.31726683
42MP0009379_abnormal_foot_pigmentation1.24405282
43MP0004885_abnormal_endolymph1.24074895
44MP0002234_abnormal_pharynx_morphology1.23519510
45MP0001849_ear_inflammation1.23061697
46MP0003329_amyloid_beta_deposits1.22996877
47MP0002063_abnormal_learning/memory/cond1.21959572
48MP0001346_abnormal_lacrimal_gland1.21391551
49MP0004782_abnormal_surfactant_physiolog1.20666935
50MP0002249_abnormal_larynx_morphology1.20518003
51MP0005076_abnormal_cell_differentiation1.19897956
52MP0004185_abnormal_adipocyte_glucose1.19242862
53MP0005083_abnormal_biliary_tract1.18392043
54MP0005220_abnormal_exocrine_pancreas1.16116153
55MP0003119_abnormal_digestive_system1.15315236
56MP0002078_abnormal_glucose_homeostasis1.14764044
57MP0005332_abnormal_amino_acid1.14645053
58MP0004130_abnormal_muscle_cell1.13892410
59MP0003183_abnormal_peptide_metabolism1.13828099
60MP0005167_abnormal_blood-brain_barrier1.13198207
61MP0010352_gastrointestinal_tract_polyps1.09789066
62MP0003122_maternal_imprinting1.08628177
63MP0005248_abnormal_Harderian_gland1.08156365
64MP0002089_abnormal_postnatal_growth/wei1.07832534
65MP0002118_abnormal_lipid_homeostasis1.07570424
66MP0003045_fibrosis1.06933952
67MP0003453_abnormal_keratinocyte_physiol1.06526273
68MP0010030_abnormal_orbit_morphology1.05392247
69MP0001765_abnormal_ion_homeostasis1.03019167
70MP0005375_adipose_tissue_phenotype1.02826100
71MP0000534_abnormal_ureter_morphology1.02381943
72MP0003942_abnormal_urinary_system1.01538445
73MP0002693_abnormal_pancreas_physiology1.00820806
74MP0002822_catalepsy0.99934554
75MP0000462_abnormal_digestive_system0.98628065
76MP0005501_abnormal_skin_physiology0.98287293
77MP0001299_abnormal_eye_distance/0.97819037
78MP0003123_paternal_imprinting0.95466164
79MP0000569_abnormal_digit_pigmentation0.95109233
80MP0002084_abnormal_developmental_patter0.92700271
81MP0001984_abnormal_olfaction0.91238990
82MP0001756_abnormal_urination0.91060665
83MP0002734_abnormal_mechanical_nocicepti0.90758977
84MP0005666_abnormal_adipose_tissue0.90632561
85MP0000377_abnormal_hair_follicle0.89813946
86MP0003861_abnormal_nervous_system0.89802241
87MP0004272_abnormal_basement_membrane0.88346934
88MP0003879_abnormal_hair_cell0.88301120
89MP0004233_abnormal_muscle_weight0.87266173
90MP0002064_seizures0.87224666
91MP0001730_embryonic_growth_arrest0.86322463
92MP0004811_abnormal_neuron_physiology0.85793485
93MP0003634_abnormal_glial_cell0.85466851
94MP0009745_abnormal_behavioral_response0.84995696
95MP0004019_abnormal_vitamin_homeostasis0.84886397
96MP0002697_abnormal_eye_size0.84035673
97MP0002928_abnormal_bile_duct0.83982122
98MP0001502_abnormal_circadian_rhythm0.83789216
99MP0003937_abnormal_limbs/digits/tail_de0.83461681
100MP0009643_abnormal_urine_homeostasis0.82660742
101MP0000627_abnormal_mammary_gland0.81773762
102MP0000778_abnormal_nervous_system0.78543401
103MP0002837_dystrophic_cardiac_calcinosis0.78194696
104MP0009672_abnormal_birth_weight0.77533557
105MP0001486_abnormal_startle_reflex0.77507664
106MP0002138_abnormal_hepatobiliary_system0.77415917
107MP0005423_abnormal_somatic_nervous0.76579495
108MP0002160_abnormal_reproductive_system0.75122358
109MP0003632_abnormal_nervous_system0.75108322
110MP0003115_abnormal_respiratory_system0.74232730
111MP0009840_abnormal_foam_cell0.74093223
112MP0000467_abnormal_esophagus_morphology0.74066507
113MP0000681_abnormal_thyroid_gland0.73795154
114MP0003953_abnormal_hormone_level0.73292648
115MP0009703_decreased_birth_body0.72821947
116MP0002572_abnormal_emotion/affect_behav0.72458573
117MP0003172_abnormal_lysosome_physiology0.72023713
118MP0003633_abnormal_nervous_system0.72016256
119MP0002233_abnormal_nose_morphology0.71815068
120MP0001664_abnormal_digestion0.71024357
121MP0002168_other_aberrant_phenotype0.71002069
122MP0005535_abnormal_body_temperature0.70771669
123MP0001177_atelectasis0.69807936
124MP0002116_abnormal_craniofacial_bone0.69787592
125MP0003718_maternal_effect0.69666643
126MP0002085_abnormal_embryonic_tissue0.68950602
127MP0000609_abnormal_liver_physiology0.68516433
128MP0010386_abnormal_urinary_bladder0.68219018
129MP0002069_abnormal_eating/drinking_beha0.67329171
130MP0003880_abnormal_central_pattern0.67188485
131MP0000955_abnormal_spinal_cord0.67018746
132MP0005646_abnormal_pituitary_gland0.66857204
133MP0005448_abnormal_energy_balance0.66841708
134MP0002557_abnormal_social/conspecific_i0.66470612
135MP0002092_abnormal_eye_morphology0.65544361
136MP0000428_abnormal_craniofacial_morphol0.65442600
137MP0009053_abnormal_anal_canal0.65399551
138MP0002272_abnormal_nervous_system0.65398928
139MP0003690_abnormal_glial_cell0.64970124
140MP0005058_abnormal_lysosome_morphology0.64836301
141MP0005645_abnormal_hypothalamus_physiol0.64548400
142MP0001672_abnormal_embryogenesis/_devel0.64308681
143MP0005380_embryogenesis_phenotype0.64308681
144MP0000678_abnormal_parathyroid_gland0.63728647
145MP0002152_abnormal_brain_morphology0.62818061
146MP0003566_abnormal_cell_adhesion0.62115464
147MP0002733_abnormal_thermal_nociception0.62003366

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.48680946
2Chronic bronchitis (HP:0004469)3.72790670
3Rhinitis (HP:0012384)3.71794408
4Abnormal respiratory motile cilium physiology (HP:0012261)3.67070703
5Abnormal ciliary motility (HP:0012262)3.49309139
6Abnormal respiratory motile cilium morphology (HP:0005938)3.33044189
7Abnormal respiratory epithelium morphology (HP:0012253)3.33044189
8Flat acetabular roof (HP:0003180)3.19410131
9Absent/shortened dynein arms (HP:0200106)3.09508556
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.09508556
11Hypoglycemic coma (HP:0001325)2.98828937
12Ketoacidosis (HP:0001993)2.96791908
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.94194131
14Hyperinsulinemic hypoglycemia (HP:0000825)2.93726813
15Hyperaldosteronism (HP:0000859)2.81916820
16Hypoglycemic seizures (HP:0002173)2.73921296
17Gout (HP:0001997)2.60361985
18Turricephaly (HP:0000262)2.53525264
19Male infertility (HP:0003251)2.52062470
20Visual hallucinations (HP:0002367)2.51850074
21Hyperglycemia (HP:0003074)2.47761676
22Abnormality of chloride homeostasis (HP:0011422)2.47697276
23Spinal cord compression (HP:0002176)2.46871335
24Abnormality of renin-angiotensin system (HP:0000847)2.46457202
25Pili torti (HP:0003777)2.44540115
26Abnormality of the lower motor neuron (HP:0002366)2.40048540
27Hyperphosphatemia (HP:0002905)2.37339429
28Cerebral aneurysm (HP:0004944)2.36902770
29Ketosis (HP:0001946)2.36356307
30Obstructive sleep apnea (HP:0002870)2.34936512
31Renal salt wasting (HP:0000127)2.34917009
32Abnormality of the dental root (HP:0006486)2.33428971
33Taurodontia (HP:0000679)2.33428971
34Abnormality of permanent molar morphology (HP:0011071)2.33428971
35Elfin facies (HP:0004428)2.28682961
36Insomnia (HP:0100785)2.28533733
37Macroorchidism (HP:0000053)2.27611802
38Neurofibrillary tangles (HP:0002185)2.27582317
39Deep venous thrombosis (HP:0002625)2.25824870
40Intrahepatic cholestasis (HP:0001406)2.23248740
41Hyperacusis (HP:0010780)2.21261947
42Bronchomalacia (HP:0002780)2.21051212
43Enlarged penis (HP:0000040)2.19689875
44Action tremor (HP:0002345)2.17435566
45Xanthomatosis (HP:0000991)2.16921608
46Aplasia of the phalanges of the hand (HP:0009802)2.16896508
47Aplasia involving bones of the extremities (HP:0009825)2.16896508
48Aplasia involving bones of the upper limbs (HP:0009823)2.16896508
49Back pain (HP:0003418)2.15316225
50Hyperparathyroidism (HP:0000843)2.14676641
51Abnormality of molar morphology (HP:0011070)2.13926441
52Abnormality of molar (HP:0011077)2.13926441
53Bronchiectasis (HP:0002110)2.13793673
54Abnormality of the distal phalanx of the thumb (HP:0009617)2.13692728
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13176537
56Papilledema (HP:0001085)2.12357360
57Ankyloglossia (HP:0010296)2.11167193
58Subacute progressive viral hepatitis (HP:0006572)2.08622203
59Hand muscle atrophy (HP:0009130)2.08066361
60Termporal pattern (HP:0011008)2.07319155
61Insidious onset (HP:0003587)2.07319155
62Renovascular hypertension (HP:0100817)2.04851994
63Hyperglycinuria (HP:0003108)2.01853008
64Symptomatic seizures (HP:0011145)2.00834546
65Resting tremor (HP:0002322)2.00368243
66Abnormality of endocrine pancreas physiology (HP:0012093)1.98524702
67Abnormality of the pancreatic islet cells (HP:0006476)1.98524702
68Shallow orbits (HP:0000586)1.97948559
69Germ cell neoplasia (HP:0100728)1.97801609
70Abnormality of the dental pulp (HP:0006479)1.97416585
71Bifid scrotum (HP:0000048)1.96801056
72Abnormality of carpal bone ossification (HP:0006257)1.96639821
73Right ventricular cardiomyopathy (HP:0011663)1.96205657
74Late onset (HP:0003584)1.96090407
75Upper limb amyotrophy (HP:0009129)1.95907646
76Distal upper limb amyotrophy (HP:0007149)1.95907646
77Infertility (HP:0000789)1.95718292
78Adrenal overactivity (HP:0002717)1.95499687
79Lymphangioma (HP:0100764)1.94549855
80Long toe (HP:0010511)1.93969627
81Global brain atrophy (HP:0002283)1.91433708
82Bundle branch block (HP:0011710)1.89844308
83Myokymia (HP:0002411)1.89218891
84Focal seizures (HP:0007359)1.89213815
85Aneurysm (HP:0002617)1.89126388
86Agitation (HP:0000713)1.87940023
87Increased circulating renin level (HP:0000848)1.87083638
88Ventricular fibrillation (HP:0001663)1.86006791
89Cerebral inclusion bodies (HP:0100314)1.85780001
90Spastic diplegia (HP:0001264)1.85016868
91Hypercalciuria (HP:0002150)1.84883809
92Vertebral arch anomaly (HP:0008438)1.84708599
93Hyperglycinemia (HP:0002154)1.84066970
94Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82719269
95Skin nodule (HP:0200036)1.82443567
96Abnormality of serine family amino acid metabolism (HP:0010894)1.81692681
97Abnormality of glycine metabolism (HP:0010895)1.81692681
98Hepatoblastoma (HP:0002884)1.81475556
99Hyperactive renin-angiotensin system (HP:0000841)1.81317757
100Papillary thyroid carcinoma (HP:0002895)1.80203414
101Bowel diverticulosis (HP:0005222)1.79997625
102Renal duplication (HP:0000075)1.79853858
103Abnormality of the salivary glands (HP:0010286)1.78937629
104Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77809116
105Buphthalmos (HP:0000557)1.77631913
106Depression (HP:0000716)1.76300335
107Abnormal ossification of hand bones (HP:0005921)1.76244786
108Ankle clonus (HP:0011448)1.75958632
109Hyponatremia (HP:0002902)1.74685434
110Megalencephaly (HP:0001355)1.74438991
111Insulin-resistant diabetes mellitus (HP:0000831)1.73666866
112Abnormality of sodium homeostasis (HP:0010931)1.69950222
113Advanced eruption of teeth (HP:0006288)1.69398832
114Atelectasis (HP:0100750)1.69236509
115Congenital glaucoma (HP:0001087)1.68141772
116Abnormality of purine metabolism (HP:0004352)1.67723428
117Nasal polyposis (HP:0100582)1.65881196
118Ulnar bowing (HP:0003031)1.65580970
119Urinary glycosaminoglycan excretion (HP:0003541)1.64720676
120Mucopolysacchariduria (HP:0008155)1.64720676
121Abnormality of the distal phalanges of the toes (HP:0010182)1.64372881
122Abnormal hand bone ossification (HP:0010660)1.64273788
123Hyperkalemia (HP:0002153)1.64232663
124Broad face (HP:0000283)1.63884892
125Dysmetric saccades (HP:0000641)1.63573459
126Short nail (HP:0001799)1.63448805
127Vascular calcification (HP:0004934)1.62966474
128Lip pit (HP:0100267)1.61390519
129Abnormality of calcium-phosphate metabolism (HP:0100530)1.60422278
130Hemiplegia (HP:0002301)1.60324403
131Abnormality of the Achilles tendon (HP:0005109)1.60088495
132Impaired social interactions (HP:0000735)1.59692529
133Abnormal social behavior (HP:0012433)1.59692529
134Overriding aorta (HP:0002623)1.59457800
135Mitral valve prolapse (HP:0001634)1.59157815
136Osteomalacia (HP:0002749)1.59052378
137Epidermoid cyst (HP:0200040)1.58966348
138Hypsarrhythmia (HP:0002521)1.58210316
139Focal segmental glomerulosclerosis (HP:0000097)1.58125644
140Transposition of the great arteries (HP:0001669)1.57954084
141Abnormal connection of the cardiac segments (HP:0011545)1.57954084
142Abnormal ventriculo-arterial connection (HP:0011563)1.57954084
143Hypoplasia of dental enamel (HP:0006297)1.57835345
144Pointed chin (HP:0000307)1.57499876
145Abnormal pancreas size (HP:0012094)1.57077659
146Impaired vibration sensation in the lower limbs (HP:0002166)1.57017284
147Pterygium (HP:0001059)1.56470464
148Retinal atrophy (HP:0001105)1.55971333
149Focal motor seizures (HP:0011153)1.55904468
150EEG with generalized epileptiform discharges (HP:0011198)1.55447342
151Hypokalemia (HP:0002900)1.54166004
152Abnormality of magnesium homeostasis (HP:0004921)1.54010373
153Intention tremor (HP:0002080)1.53966035
154Abnormality of oral frenula (HP:0000190)1.53749947
155Asymmetry of the thorax (HP:0001555)1.53430952
156Abnormality of the intrinsic pathway (HP:0010989)1.52981719
157Pancreatic islet-cell hyperplasia (HP:0004510)1.52969494
158Thin bony cortex (HP:0002753)1.52929981
159Unilateral renal agenesis (HP:0000122)1.52158317
160Hypercortisolism (HP:0001578)1.52061741
161Polygenic inheritance (HP:0010982)1.51721662
162Abnormality of the astrocytes (HP:0100707)1.51420367
163Astrocytoma (HP:0009592)1.51420367
164Glomerulosclerosis (HP:0000096)1.51399233
165Hypokalemic alkalosis (HP:0001949)1.51291405
166Metabolic alkalosis (HP:0200114)1.51197035
167Abnormality of the gastric mucosa (HP:0004295)1.50807757
168Hypotension (HP:0002615)1.48765514
169Proximal tubulopathy (HP:0000114)1.48214798
170Tracheal stenosis (HP:0002777)1.46417258
171Coronal craniosynostosis (HP:0004440)1.44655647
172Neonatal death (HP:0003811)1.42390853
173Arnold-Chiari malformation (HP:0002308)1.41171751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.21815097
2MAP3K92.80756297
3MAP3K22.68263961
4KSR22.58705068
5PKN22.52834740
6PRKD32.44263205
7LATS12.40376962
8FRK2.38880010
9NTRK32.36292079
10RIPK12.27341703
11PDGFRA2.21502299
12SMG12.01346113
13SCYL21.98464134
14PAK61.79424471
15NTRK11.73885948
16CAMKK11.72889101
17DAPK21.72759212
18INSRR1.66257078
19DDR21.66161013
20NEK61.63330049
21SIK11.56161912
22EPHA41.55546304
23PTK61.55275773
24MAP3K41.54824322
25LATS21.50886090
26EPHA21.49301548
27STK391.46688372
28STK381.43204836
29TTK1.42072974
30PAK31.41783737
31FER1.37305942
32RET1.34996498
33LMTK21.34294071
34KSR11.33271007
35ARAF1.31410018
36PTK21.30826260
37MAP2K41.25224384
38TYRO31.19374632
39WNK31.17858596
40MINK11.17627406
41EEF2K1.15419985
42ALK1.14548809
43CASK1.13758855
44PNCK1.13236348
45NEK11.10770706
46WNK41.10205783
47ERN11.06720415
48MST1R1.06002308
49STK241.05575735
50ICK1.04418689
51CAMK1G1.01314011
52MARK11.01238117
53MET1.00696574
54FGFR20.95611537
55PRKCH0.95583083
56MAP2K10.92489175
57OXSR10.91788997
58TAOK10.90269490
59CAMK1D0.89397773
60MAP3K10.87029257
61SGK30.84626621
62MST40.83446208
63CDC42BPA0.83036758
64MTOR0.82017983
65FGFR40.81874185
66CDK120.81423122
67BCKDK0.77978418
68BMX0.77863087
69STK38L0.77436596
70PBK0.77327275
71CDK50.74117988
72NTRK20.73616112
73PDGFRB0.72176517
74CAMKK20.72007454
75RPS6KB20.71365048
76MAP3K120.71074406
77PDPK10.69515288
78BRAF0.69143817
79MAP3K100.68578746
80ERBB20.68348709
81MARK20.67347641
82UHMK10.66772331
83PASK0.66754652
84STK110.66286498
85TAOK30.66221613
86FGFR10.65354203
87PAK20.63662559
88HIPK20.63409511
89MAP3K130.62452361
90CDK60.61970358
91WNK10.60615379
92MAP3K70.59880772
93SGK2230.59205784
94SGK4940.59205784
95PRKCI0.57273642
96BRD40.56582608
97CAMK2B0.55801055
98PRKAA10.55338321
99TSSK60.54808368
100AKT20.53833835
101PIK3CA0.52911033
102CSNK1E0.52098966
103IRAK30.52061484
104ERBB40.51773813
105STK30.51728391
106SGK20.51707031
107MAPK100.50370213
108PDK10.50068910
109AKT30.49782752
110TTN0.49647181
111FGFR30.49589910
112MAP2K20.48713635
113CAMK2G0.48712806
114PRKCZ0.47948071
115BRSK10.47344231
116RPS6KB10.47073348
117MELK0.46691087
118CSNK1G20.46336581
119PRKCG0.44922231
120PAK40.44492313
121DYRK1B0.43095652
122SGK10.42829527
123RPS6KA30.42363562
124ERBB30.42037342
125RPS6KA20.41597909
126DMPK0.41062830
127PRKG20.40979172
128MAPK150.40918123
129PHKG10.40708817
130PHKG20.40708817
131CAMK2D0.40245877
132PDK40.39816166
133PDK30.39816166
134DAPK10.38768125
135JAK20.38424395
136TESK10.38242796
137SIK20.37865419
138ROCK20.36940432

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.84225336
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.39389236
3Histidine metabolism_Homo sapiens_hsa003402.02358224
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01184708
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85609659
6Phenylalanine metabolism_Homo sapiens_hsa003601.85236371
7Vitamin B6 metabolism_Homo sapiens_hsa007501.82309153
8Insulin secretion_Homo sapiens_hsa049111.77960073
9Bile secretion_Homo sapiens_hsa049761.75678597
10Arginine biosynthesis_Homo sapiens_hsa002201.70581039
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66650289
12Type II diabetes mellitus_Homo sapiens_hsa049301.54841484
13Butanoate metabolism_Homo sapiens_hsa006501.47725957
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45158498
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43049172
16Olfactory transduction_Homo sapiens_hsa047401.37342721
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36156822
18Sulfur metabolism_Homo sapiens_hsa009201.36010211
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34138219
20Fatty acid degradation_Homo sapiens_hsa000711.33302500
21Thyroid cancer_Homo sapiens_hsa052161.28502690
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.26324541
23Gastric acid secretion_Homo sapiens_hsa049711.25891940
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24303781
25Arginine and proline metabolism_Homo sapiens_hsa003301.24037358
26Synaptic vesicle cycle_Homo sapiens_hsa047211.23920317
27Long-term potentiation_Homo sapiens_hsa047201.23048585
28Thyroid hormone synthesis_Homo sapiens_hsa049181.16814135
29Tryptophan metabolism_Homo sapiens_hsa003801.16735517
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16107818
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15959191
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15571203
33Fat digestion and absorption_Homo sapiens_hsa049751.15308681
34GABAergic synapse_Homo sapiens_hsa047271.14923184
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13567652
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12005635
37Pancreatic secretion_Homo sapiens_hsa049721.08553733
38Amphetamine addiction_Homo sapiens_hsa050311.07711792
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.07363910
40Circadian entrainment_Homo sapiens_hsa047131.06686686
41Salivary secretion_Homo sapiens_hsa049701.04466568
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04130063
43mTOR signaling pathway_Homo sapiens_hsa041501.03270618
44Estrogen signaling pathway_Homo sapiens_hsa049151.03074734
45PPAR signaling pathway_Homo sapiens_hsa033201.02749558
46Dopaminergic synapse_Homo sapiens_hsa047280.97325076
47Fatty acid metabolism_Homo sapiens_hsa012120.95825232
48Glioma_Homo sapiens_hsa052140.94949385
49Glucagon signaling pathway_Homo sapiens_hsa049220.94751199
50Inositol phosphate metabolism_Homo sapiens_hsa005620.94554844
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93615085
52Glutamatergic synapse_Homo sapiens_hsa047240.91440250
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90709781
54Propanoate metabolism_Homo sapiens_hsa006400.89601176
55GnRH signaling pathway_Homo sapiens_hsa049120.89159491
56Tyrosine metabolism_Homo sapiens_hsa003500.88425324
57Insulin resistance_Homo sapiens_hsa049310.87901396
58Cholinergic synapse_Homo sapiens_hsa047250.87606692
59Sphingolipid metabolism_Homo sapiens_hsa006000.86770543
60Protein digestion and absorption_Homo sapiens_hsa049740.86700480
61Vitamin digestion and absorption_Homo sapiens_hsa049770.84740731
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83439529
63Dorso-ventral axis formation_Homo sapiens_hsa043200.83082338
64Selenocompound metabolism_Homo sapiens_hsa004500.82766808
65Cocaine addiction_Homo sapiens_hsa050300.82546105
66Lysine degradation_Homo sapiens_hsa003100.80413470
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79580715
68Endometrial cancer_Homo sapiens_hsa052130.78171862
69Glycerolipid metabolism_Homo sapiens_hsa005610.77217989
70Gap junction_Homo sapiens_hsa045400.77161512
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77018530
72Renin secretion_Homo sapiens_hsa049240.76737707
73Choline metabolism in cancer_Homo sapiens_hsa052310.76185178
74Axon guidance_Homo sapiens_hsa043600.75855302
75Insulin signaling pathway_Homo sapiens_hsa049100.75612414
76Bladder cancer_Homo sapiens_hsa052190.75414286
77Melanogenesis_Homo sapiens_hsa049160.75186518
78Taste transduction_Homo sapiens_hsa047420.73710674
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73399891
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72323077
81Morphine addiction_Homo sapiens_hsa050320.71095809
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71004658
83Starch and sucrose metabolism_Homo sapiens_hsa005000.70487776
84Circadian rhythm_Homo sapiens_hsa047100.69851120
85Fructose and mannose metabolism_Homo sapiens_hsa000510.68680462
86AMPK signaling pathway_Homo sapiens_hsa041520.67089167
87Tight junction_Homo sapiens_hsa045300.67034181
88Mineral absorption_Homo sapiens_hsa049780.66083095
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65873997
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65855186
91Wnt signaling pathway_Homo sapiens_hsa043100.65642276
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64636304
93Prion diseases_Homo sapiens_hsa050200.64412001
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.64041783
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63534680
96Nicotine addiction_Homo sapiens_hsa050330.63475988
97Adherens junction_Homo sapiens_hsa045200.62633623
98Oocyte meiosis_Homo sapiens_hsa041140.60611635
99cAMP signaling pathway_Homo sapiens_hsa040240.60563285
100Ovarian steroidogenesis_Homo sapiens_hsa049130.59953501
101Oxytocin signaling pathway_Homo sapiens_hsa049210.58750985
102ECM-receptor interaction_Homo sapiens_hsa045120.58709654
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58515885
104Fatty acid biosynthesis_Homo sapiens_hsa000610.58197354
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57834885
106Notch signaling pathway_Homo sapiens_hsa043300.56676906
107Hippo signaling pathway_Homo sapiens_hsa043900.55161744
108Pyruvate metabolism_Homo sapiens_hsa006200.55021500
109Carbon metabolism_Homo sapiens_hsa012000.54119375
110Long-term depression_Homo sapiens_hsa047300.53550087
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.53274329
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.53181762
113VEGF signaling pathway_Homo sapiens_hsa043700.52416978
114ErbB signaling pathway_Homo sapiens_hsa040120.52351576
115beta-Alanine metabolism_Homo sapiens_hsa004100.52136036
116Basal cell carcinoma_Homo sapiens_hsa052170.52084546
117ABC transporters_Homo sapiens_hsa020100.52003948
118Galactose metabolism_Homo sapiens_hsa000520.51680620
119Hedgehog signaling pathway_Homo sapiens_hsa043400.51370892
120Renal cell carcinoma_Homo sapiens_hsa052110.51326517
121Proteoglycans in cancer_Homo sapiens_hsa052050.49851424
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49186608
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47968944
124Vibrio cholerae infection_Homo sapiens_hsa051100.47936201
125Biosynthesis of amino acids_Homo sapiens_hsa012300.47689346
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.47166019
127Focal adhesion_Homo sapiens_hsa045100.46954865
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46952125

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