CMTM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.73827686
2ensheathment of neurons (GO:0007272)7.07473050
3axon ensheathment (GO:0008366)7.07473050
4myelination (GO:0042552)7.04560961
5thrombin receptor signaling pathway (GO:0070493)6.20662107
6neutrophil activation involved in immune response (GO:0002283)6.08383015
7long-chain fatty acid biosynthetic process (GO:0042759)6.06989140
8adenosine receptor signaling pathway (GO:0001973)5.84903776
9myelin maintenance (GO:0043217)5.83104210
10regulation of platelet aggregation (GO:0090330)5.69271342
11regulation of platelet activation (GO:0010543)5.09415273
12oligodendrocyte differentiation (GO:0048709)5.06454133
13cholesterol biosynthetic process (GO:0006695)4.89255817
14platelet aggregation (GO:0070527)4.88159661
15creatine metabolic process (GO:0006600)4.74108981
16blood coagulation, intrinsic pathway (GO:0007597)4.70817252
17negative regulation of protein localization to cell surface (GO:2000009)4.66723116
18negative regulation of neurotransmitter secretion (GO:0046929)4.65300132
19negative regulation of neurotransmitter transport (GO:0051589)4.53589861
20negative regulation of homotypic cell-cell adhesion (GO:0034111)4.51479671
21establishment of mitochondrion localization (GO:0051654)4.47593420
22apical protein localization (GO:0045176)4.34852430
23response to methylmercury (GO:0051597)4.29189965
24regulation of collateral sprouting (GO:0048670)4.26679924
25sterol biosynthetic process (GO:0016126)4.25486079
26glycerophospholipid catabolic process (GO:0046475)4.22736249
27negative regulation of heart rate (GO:0010459)4.21409630
28regulation of integrin-mediated signaling pathway (GO:2001044)4.21020173
29L-amino acid import (GO:0043092)4.20611876
30asymmetric protein localization (GO:0008105)4.18022216
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.13098307
32photoreceptor cell differentiation (GO:0046530)4.10570111
33eye photoreceptor cell differentiation (GO:0001754)4.10570111
34astrocyte development (GO:0014002)4.08184283
35presynaptic membrane organization (GO:0097090)4.07978405
36positive regulation of oligodendrocyte differentiation (GO:0048714)4.06164431
37negative regulation of platelet activation (GO:0010544)4.04990051
38positive regulation of mast cell activation (GO:0033005)4.03123414
39long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.97204209
40amyloid precursor protein metabolic process (GO:0042982)3.93537821
41negative regulation of norepinephrine secretion (GO:0010700)3.92039931
42substantia nigra development (GO:0021762)3.83573617
43isoprenoid biosynthetic process (GO:0008299)3.80830671
44presynaptic membrane assembly (GO:0097105)3.77982480
45lipoxygenase pathway (GO:0019372)3.74292970
46positive regulation of endothelial cell differentiation (GO:0045603)3.73588184
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.70619909
48response to redox state (GO:0051775)3.69071681
49peripheral nervous system axon ensheathment (GO:0032292)3.68038020
50myelination in peripheral nervous system (GO:0022011)3.68038020
51platelet degranulation (GO:0002576)3.66895590
52neutrophil activation (GO:0042119)3.65409913
53response to lipoprotein particle (GO:0055094)3.64595360
54adhesion of symbiont to host cell (GO:0044650)3.64524499
55virion attachment to host cell (GO:0019062)3.64524499
56negative regulation of heart contraction (GO:0045822)3.64069063
57import into cell (GO:0098657)3.61298326
58angiogenesis involved in wound healing (GO:0060055)3.56262124
59homotypic cell-cell adhesion (GO:0034109)3.55189137
60positive regulation of receptor recycling (GO:0001921)3.55185354
61megakaryocyte development (GO:0035855)3.54718681
62peptidyl-tyrosine autophosphorylation (GO:0038083)3.50590785
63G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.47852326
64fatty-acyl-CoA biosynthetic process (GO:0046949)3.44315646
65relaxation of smooth muscle (GO:0044557)3.43966733
66G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.42658814
67negative regulation of thymocyte apoptotic process (GO:0070244)3.42600973
68platelet activation (GO:0030168)3.40887405
69regulation of homotypic cell-cell adhesion (GO:0034110)3.38851836
70regulation of lipoprotein metabolic process (GO:0050746)3.38711166
71negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.38575039
72purinergic receptor signaling pathway (GO:0035587)3.35422155
73low-density lipoprotein particle remodeling (GO:0034374)3.30757823
74purinergic nucleotide receptor signaling pathway (GO:0035590)3.28393480
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.28280119
76negative regulation of neural precursor cell proliferation (GO:2000178)3.28093563
77positive regulation of Rho protein signal transduction (GO:0035025)3.27727539
78fatty-acyl-CoA metabolic process (GO:0035337)3.27722857
79protein palmitoylation (GO:0018345)3.26513874
80platelet formation (GO:0030220)3.25317037
81very long-chain fatty acid metabolic process (GO:0000038)3.24758671
82GPI anchor biosynthetic process (GO:0006506)3.22892150
83axon development (GO:0061564)3.22783819
84positive regulation of cAMP-mediated signaling (GO:0043950)3.22758444
85regulation of female receptivity (GO:0045924)3.22592811
86amino acid import (GO:0043090)3.22284743
87regulation of integrin activation (GO:0033623)3.22141197
88GPI anchor metabolic process (GO:0006505)3.21172659
89negative regulation of appetite (GO:0032099)3.20526247
90negative regulation of response to food (GO:0032096)3.20526247
91membrane tubulation (GO:0097320)3.18685607
92activation of protein kinase A activity (GO:0034199)3.17863347
93granulocyte activation (GO:0036230)3.17389534
94nucleotide transmembrane transport (GO:1901679)3.15854562
95positive regulation of macrophage differentiation (GO:0045651)3.14061123
96regulation of synaptic vesicle exocytosis (GO:2000300)3.13698478
97glycosylceramide metabolic process (GO:0006677)3.06462542
98adult walking behavior (GO:0007628)3.05021611
99beta-amyloid metabolic process (GO:0050435)3.03009945
100regulation of inositol phosphate biosynthetic process (GO:0010919)2.98156331
101limb bud formation (GO:0060174)2.98060750
102magnesium ion transport (GO:0015693)2.97181697
103amyloid precursor protein catabolic process (GO:0042987)2.96704968
104positive regulation of hemostasis (GO:1900048)2.95482035
105positive regulation of blood coagulation (GO:0030194)2.95482035
106neuron remodeling (GO:0016322)2.94713109
107polyamine biosynthetic process (GO:0006596)2.94569598
108cerebral cortex radially oriented cell migration (GO:0021799)2.93981042
109regulation of sensory perception (GO:0051931)2.93264155
110regulation of sensory perception of pain (GO:0051930)2.93264155
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92720376
112negative regulation of axonogenesis (GO:0050771)2.92322192
113neuron cell-cell adhesion (GO:0007158)2.90584036
114neurotransmitter uptake (GO:0001504)2.90233091
115positive regulation of cellular amide metabolic process (GO:0034250)2.86977441
116glial cell development (GO:0021782)2.86034370
117positive regulation of glial cell differentiation (GO:0045687)2.82897721
118positive regulation of systemic arterial blood pressure (GO:0003084)2.82145869
119regulation of MHC class II biosynthetic process (GO:0045346)2.82060805
120transmission of nerve impulse (GO:0019226)2.81418418
121positive regulation of action potential (GO:0045760)2.79464966
122regulation of norepinephrine secretion (GO:0014061)2.79265158
123fusion of sperm to egg plasma membrane (GO:0007342)2.79236354
124regulation of Golgi to plasma membrane protein transport (GO:0042996)2.76915350
125termination of G-protein coupled receptor signaling pathway (GO:0038032)2.76268491
126thioester biosynthetic process (GO:0035384)2.76052271
127acyl-CoA biosynthetic process (GO:0071616)2.76052271
128cyclooxygenase pathway (GO:0019371)2.75678754
129female mating behavior (GO:0060180)2.75464619
130termination of signal transduction (GO:0023021)2.74651123
131positive regulation of mast cell activation involved in immune response (GO:0033008)2.73780773
132positive regulation of mast cell degranulation (GO:0043306)2.73780773
133preassembly of GPI anchor in ER membrane (GO:0016254)2.73295310
134leukocyte migration involved in inflammatory response (GO:0002523)2.73132318
135regulation of mast cell degranulation (GO:0043304)2.72607962
136vesicle targeting (GO:0006903)2.72544866
137actin filament polymerization (GO:0030041)2.71175755
138positive regulation of cellular amine metabolic process (GO:0033240)2.70918733
139negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.70675343
140glial cell differentiation (GO:0010001)2.70535787
141positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.69776022
142negative regulation of JUN kinase activity (GO:0043508)2.68880934
143negative regulation of erythrocyte differentiation (GO:0045647)2.68439543
144enteric nervous system development (GO:0048484)2.67965802
145iron coordination entity transport (GO:1901678)2.67706776
146regulation of macrophage derived foam cell differentiation (GO:0010743)2.67360243
147extracellular fibril organization (GO:0043206)2.67264227
148vesicle docking involved in exocytosis (GO:0006904)2.66679347
149negative regulation of blood circulation (GO:1903523)2.66052934
150positive regulation of coagulation (GO:0050820)2.65815883
151negative regulation of calcium ion transmembrane transport (GO:1903170)2.65172574
152negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.65172574
153nucleotide transport (GO:0006862)2.64058540
154regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.63484246
155peptidyl-cysteine modification (GO:0018198)2.63397312
156regulation of receptor recycling (GO:0001919)2.63350839
157positive regulation of gliogenesis (GO:0014015)2.63345578
158negative regulation of muscle contraction (GO:0045932)2.62574136
159heme transport (GO:0015886)2.61647375
160relaxation of muscle (GO:0090075)2.61476212
161leukocyte degranulation (GO:0043299)2.61395745
162negative regulation of execution phase of apoptosis (GO:1900118)2.60801516
163adhesion of symbiont to host (GO:0044406)2.60288609
164cellular response to epinephrine stimulus (GO:0071872)2.59850262
165regulation of mast cell activation (GO:0033003)2.59785518
166negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.59459207
167negative regulation of macroautophagy (GO:0016242)2.58748871
168neural nucleus development (GO:0048857)2.58547531
169regulation of cholesterol efflux (GO:0010874)2.58065224
170peripheral nervous system development (GO:0007422)2.57639264
171regulation of mast cell activation involved in immune response (GO:0033006)2.57605582
172regulation of clathrin-mediated endocytosis (GO:2000369)2.55542220
173negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.55140992
174response to lead ion (GO:0010288)2.52406424
175negative regulation of acute inflammatory response (GO:0002674)2.52360579
176regulation of somitogenesis (GO:0014807)2.49190987
177mannosylation (GO:0097502)2.46397232
178interleukin-6-mediated signaling pathway (GO:0070102)2.44994838
179negative regulation of inclusion body assembly (GO:0090084)2.42936919
180cerebellar granule cell differentiation (GO:0021707)2.42890287
181neuronal action potential propagation (GO:0019227)2.42653832
182glutathione biosynthetic process (GO:0006750)2.42642019
183protein neddylation (GO:0045116)2.42468691
184membrane raft organization (GO:0031579)2.41247312
185nerve growth factor signaling pathway (GO:0038180)2.40805738
186microtubule polymerization or depolymerization (GO:0031109)2.38515480
187organ growth (GO:0035265)2.37739120
188central nervous system myelination (GO:0022010)12.2742358
189axon ensheathment in central nervous system (GO:0032291)12.2742358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.32007562
2SCL_19346495_ChIP-Seq_HPC-7_Human3.78940364
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.54603366
4GBX2_23144817_ChIP-Seq_PC3_Human3.13084780
5GATA1_19941826_ChIP-Seq_K562_Human2.71535506
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71118879
7* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.70379776
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65204528
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.64045571
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60926106
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.53837573
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42231067
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40817694
14LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.39547759
15EZH2_22144423_ChIP-Seq_EOC_Human2.30591585
16GATA2_19941826_ChIP-Seq_K562_Human2.21097645
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19759822
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17924119
19TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.12794797
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.12538005
21SPI1_23127762_ChIP-Seq_K562_Human2.10932613
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09919974
23TAF15_26573619_Chip-Seq_HEK293_Human2.08156058
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06848720
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03872279
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03872279
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.03394414
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.02142261
29AR_21572438_ChIP-Seq_LNCaP_Human1.99644475
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99198582
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97699986
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97115479
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95180803
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93572412
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.92835614
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.90580394
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88056331
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86307765
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85653658
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.84565598
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84306058
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84270180
43* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81514076
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80706617
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.78966605
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78301539
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75847577
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71990570
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70040128
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.65805011
51GATA1_22025678_ChIP-Seq_K562_Human1.65109118
52ER_23166858_ChIP-Seq_MCF-7_Human1.62212835
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.61649313
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61422704
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61206031
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.58494166
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57341838
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55705138
59ELK4_26923725_Chip-Seq_MESODERM_Mouse1.54043382
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51807259
61GATA1_19941827_ChIP-Seq_MEL86_Mouse1.49898048
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.49236953
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48590637
64DROSHA_22980978_ChIP-Seq_HELA_Human1.46724379
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.42852874
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41287299
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40933338
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39980114
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39692292
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.38623417
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33668072
72VDR_22108803_ChIP-Seq_LS180_Human1.33606540
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33330973
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32425218
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.31591700
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30683650
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28733213
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28038990
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27755392
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26765874
81RUNX_20019798_ChIP-Seq_JUKART_Human1.23984794
82P300_19829295_ChIP-Seq_ESCs_Human1.21783229
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20991993
84FUS_26573619_Chip-Seq_HEK293_Human1.20486724
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19357502
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19092509
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16728125
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16728125
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14548112
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13884349
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.11905550
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.11130073
93REST_21632747_ChIP-Seq_MESCs_Mouse1.10945417
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.10797348
95EOMES_21245162_ChIP-Seq_HESCs_Human1.10171128
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.09871349
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09695981
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09369509
99HTT_18923047_ChIP-ChIP_STHdh_Human1.07128526
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.06771338
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06366302
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05321097
103STAT3_23295773_ChIP-Seq_U87_Human1.05045480
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02927927
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.01978654
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.01912699
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.01828752
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01725061
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01304447
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00902834
111P300_18555785_Chip-Seq_ESCs_Mouse0.99932832
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99526298
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99283899
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98357439
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98147163
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96434015
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.95844492
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94962881
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94532405
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94389187
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93260382
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92897552
123TCF4_23295773_ChIP-Seq_U87_Human0.92669373
124SMAD4_21799915_ChIP-Seq_A2780_Human0.92558464
125RNF2_27304074_Chip-Seq_NSC_Mouse0.92508908
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92283600
127TCF7_22412390_ChIP-Seq_EML_Mouse0.91881616
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91159783
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90804833
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90746337
131REST_18959480_ChIP-ChIP_MESCs_Mouse0.90221534
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90156559
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.89849337
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89505486
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.89279152
136NANOG_19829295_ChIP-Seq_ESCs_Human0.88862745
137SOX2_19829295_ChIP-Seq_ESCs_Human0.88862745
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88645454
139* SPI1_20517297_ChIP-Seq_HL60_Human0.88252805
140TBL1_22424771_ChIP-Seq_293T_Human0.87739489
141LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87038608
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.86972367
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86894967
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86132680
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85920527
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84815897
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84622164
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84610276
149AHR_22903824_ChIP-Seq_MCF-7_Human0.84531043
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84005756
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83891040
152ESR2_21235772_ChIP-Seq_MCF-7_Human0.83533056
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83470722
154GF1_26923725_Chip-Seq_HPCs_Mouse0.83282468
155ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82940108
156UTX_26944678_Chip-Seq_JUKART_Human0.76887116
157CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75163383
158EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74946704
159RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73696731
160RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73570504
161OCT1_27270436_Chip-Seq_PROSTATE_Human0.73497632
162CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73190864
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72886488
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72841138
165NCOR1_26117541_ChIP-Seq_K562_Human0.72764602
166CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72292553
167VDR_24763502_ChIP-Seq_THP-1_Human0.70796471
168LXR_22292898_ChIP-Seq_THP-1_Human0.70670540
169PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70225966
170STAT1_20625510_ChIP-Seq_HELA_Human0.68510381
171NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68335053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.39835484
2MP0000920_abnormal_myelination5.55472098
3MP0008004_abnormal_stomach_pH4.46954645
4MP0003950_abnormal_plasma_membrane3.76608276
5MP0003724_increased_susceptibility_to3.47155519
6MP0003690_abnormal_glial_cell3.46554127
7MP0003880_abnormal_central_pattern3.39852741
8MP0004270_analgesia3.22615842
9MP0000465_gastrointestinal_hemorrhage3.18695109
10MP0004510_myositis3.00317762
11MP0003329_amyloid_beta_deposits2.93547691
12MP0003136_yellow_coat_color2.85856739
13MP0004885_abnormal_endolymph2.81608762
14MP0005171_absent_coat_pigmentation2.77670821
15MP0001529_abnormal_vocalization2.74999525
16MP0003634_abnormal_glial_cell2.57024894
17MP0004742_abnormal_vestibular_system2.52783500
18MP0001905_abnormal_dopamine_level2.52734659
19MP0001486_abnormal_startle_reflex2.52686335
20MP0002272_abnormal_nervous_system2.40980099
21MP0003303_peritoneal_inflammation2.39110631
22MP0005167_abnormal_blood-brain_barrier2.35776587
23MP0004142_abnormal_muscle_tone2.21482249
24MP0003879_abnormal_hair_cell2.17771394
25MP0004084_abnormal_cardiac_muscle2.14136556
26MP0001485_abnormal_pinna_reflex2.10957726
27MP0002064_seizures2.07056121
28MP0000778_abnormal_nervous_system2.05781877
29MP0005409_darkened_coat_color2.03517695
30MP0000343_altered_response_to2.02102542
31MP0005410_abnormal_fertilization1.91553974
32MP0002229_neurodegeneration1.87336350
33MP0004130_abnormal_muscle_cell1.85822836
34MP0003632_abnormal_nervous_system1.83549950
35MP0005083_abnormal_biliary_tract1.79531364
36MP0004043_abnormal_pH_regulation1.79026515
37MP0003566_abnormal_cell_adhesion1.78853612
38MP0004859_abnormal_synaptic_plasticity1.75556222
39MP0005423_abnormal_somatic_nervous1.72416482
40MP0004381_abnormal_hair_follicle1.72021560
41MP0002734_abnormal_mechanical_nocicepti1.69026373
42MP0000230_abnormal_systemic_arterial1.68373565
43MP0009046_muscle_twitch1.67840721
44MP0003806_abnormal_nucleotide_metabolis1.63094547
45MP0000462_abnormal_digestive_system1.60448448
46MP0009745_abnormal_behavioral_response1.58911421
47MP0003828_pulmonary_edema1.56928837
48MP0003635_abnormal_synaptic_transmissio1.55090491
49MP0000604_amyloidosis1.54012208
50MP0010678_abnormal_skin_adnexa1.53901592
51MP0005451_abnormal_body_composition1.52645348
52MP0003638_abnormal_response/metabolism_1.51472161
53MP0008775_abnormal_heart_ventricle1.50493261
54MP0000383_abnormal_hair_follicle1.49620082
55MP0001835_abnormal_antigen_presentation1.48838506
56MP0004134_abnormal_chest_morphology1.48341894
57MP0003631_nervous_system_phenotype1.46087443
58MP0008874_decreased_physiological_sensi1.45580138
59MP0005551_abnormal_eye_electrophysiolog1.39653255
60MP0001440_abnormal_grooming_behavior1.37707023
61MP0004215_abnormal_myocardial_fiber1.36910017
62MP0000955_abnormal_spinal_cord1.36431368
63MP0000566_synostosis1.35644563
64MP0002882_abnormal_neuron_morphology1.34065988
65MP0008569_lethality_at_weaning1.32399515
66MP0002572_abnormal_emotion/affect_behav1.31184018
67MP0005000_abnormal_immune_tolerance1.31103510
68MP0003633_abnormal_nervous_system1.29023887
69MP0001970_abnormal_pain_threshold1.27070956
70MP0008260_abnormal_autophagy1.26300451
71MP0001963_abnormal_hearing_physiology1.25927043
72MP0008872_abnormal_physiological_respon1.24181126
73MP0004147_increased_porphyrin_level1.22125598
74MP0002066_abnormal_motor_capabilities/c1.20501293
75MP0010155_abnormal_intestine_physiology1.18551933
76MP0005671_abnormal_response_to1.17586012
77MP0001299_abnormal_eye_distance/1.17224304
78MP0003436_decreased_susceptibility_to1.15808075
79MP0002067_abnormal_sensory_capabilities1.15245162
80MP0002063_abnormal_learning/memory/cond1.14715782
81MP0009840_abnormal_foam_cell1.14693652
82MP0002752_abnormal_somatic_nervous1.13226279
83MP0001346_abnormal_lacrimal_gland1.13204269
84MP0000747_muscle_weakness1.13005132
85MP0002148_abnormal_hypersensitivity_rea1.11561369
86MP0005386_behavior/neurological_phenoty1.10749645
87MP0004924_abnormal_behavior1.10749645
88MP0000249_abnormal_blood_vessel1.09840528
89MP0003866_abnormal_defecation1.08489705
90MP0001533_abnormal_skeleton_physiology1.08281128
91MP0002398_abnormal_bone_marrow1.07950015
92MP0000647_abnormal_sebaceous_gland1.07764230
93MP0005058_abnormal_lysosome_morphology1.05635777
94MP0002972_abnormal_cardiac_muscle1.05214024
95MP0004947_skin_inflammation1.04966922
96MP0002733_abnormal_thermal_nociception1.03573633
97MP0009780_abnormal_chondrocyte_physiolo1.03549615
98MP0003183_abnormal_peptide_metabolism1.03369801
99MP0001545_abnormal_hematopoietic_system1.02946275
100MP0005397_hematopoietic_system_phenotyp1.02946275
101MP0003300_gastrointestinal_ulcer1.02653235
102MP0001661_extended_life_span1.00898022
103MP0005535_abnormal_body_temperature0.99599919
104MP0004484_altered_response_of0.97421526
105MP0005195_abnormal_posterior_eye0.96606021
106MP0001663_abnormal_digestive_system0.95933217
107MP0006276_abnormal_autonomic_nervous0.95237031
108MP0005165_increased_susceptibility_to0.94706453
109MP0002723_abnormal_immune_serum0.92490252
110MP0005623_abnormal_meninges_morphology0.91864677
111MP0001177_atelectasis0.91837234
112MP0001851_eye_inflammation0.90698187
113MP0003938_abnormal_ear_development0.90532654
114MP0001502_abnormal_circadian_rhythm0.90428155
115MP0002736_abnormal_nociception_after0.89635937
116MP0002132_abnormal_respiratory_system0.89555839
117MP0003195_calcinosis0.89365135
118MP0000762_abnormal_tongue_morphology0.89250057
119MP0001879_abnormal_lymphatic_vessel0.89179419
120MP0001968_abnormal_touch/_nociception0.88999572
121MP0000026_abnormal_inner_ear0.87211376
122MP0009763_increased_sensitivity_to0.87187662
123MP0004145_abnormal_muscle_electrophysio0.85872431
124MP0005084_abnormal_gallbladder_morpholo0.85783143
125MP0003656_abnormal_erythrocyte_physiolo0.85457746
126MP0002419_abnormal_innate_immunity0.83504306
127MP0009764_decreased_sensitivity_to0.82879249
128MP0005253_abnormal_eye_physiology0.82523370
129MP0003937_abnormal_limbs/digits/tail_de0.82280258
130MP0002295_abnormal_pulmonary_circulatio0.82055740
131MP0000579_abnormal_nail_morphology0.82004350
132MP0004085_abnormal_heartbeat0.81478132
133MP0005620_abnormal_muscle_contractility0.79903675
134MP0001544_abnormal_cardiovascular_syste0.79474691
135MP0005385_cardiovascular_system_phenoty0.79474691
136MP0002152_abnormal_brain_morphology0.79403001
137MP0001800_abnormal_humoral_immune0.78619066
138MP0002735_abnormal_chemical_nociception0.78445276
139MP0001348_abnormal_lacrimal_gland0.78236999
140MP0010329_abnormal_lipoprotein_level0.76439180
141MP0005645_abnormal_hypothalamus_physiol0.75384543
142MP0005025_abnormal_response_to0.74979995
143MP0002420_abnormal_adaptive_immunity0.74811533
144MP0002998_abnormal_bone_remodeling0.74794323
145MP0002429_abnormal_blood_cell0.73100331
146MP0001819_abnormal_immune_cell0.72874308
147MP0003172_abnormal_lysosome_physiology0.72056599
148MP0002452_abnormal_antigen_presenting0.71802447
149MP0001765_abnormal_ion_homeostasis0.70460751
150MP0006072_abnormal_retinal_apoptosis0.70135876
151MP0005646_abnormal_pituitary_gland0.68591645
152MP0002557_abnormal_social/conspecific_i0.68062512
153MP0003137_abnormal_impulse_conducting0.67349758
154MP0000467_abnormal_esophagus_morphology0.67063368
155MP0008438_abnormal_cutaneous_collagen0.66864912
156MP0001501_abnormal_sleep_pattern0.65925894
157MP0005408_hypopigmentation0.65793788
158MP0004133_heterotaxia0.63972181
159MP0004036_abnormal_muscle_relaxation0.63648950
160MP0002090_abnormal_vision0.63253883
161MP0002938_white_spotting0.60278325
162MP0003075_altered_response_to0.58930970
163MP0009250_abnormal_appendicular_skeleto0.58638375
164MP0002184_abnormal_innervation0.58162480

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)9.78550754
2Increased mean platelet volume (HP:0011877)9.78019486
3Abnormal platelet volume (HP:0011876)9.34211111
4Petechiae (HP:0000967)9.00666089
5Purpura (HP:0000979)8.61115425
6Epistaxis (HP:0000421)7.01881587
7Neurofibrillary tangles (HP:0002185)6.55955561
8Degeneration of the lateral corticospinal tracts (HP:0002314)6.30810379
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.30810379
10Gingival bleeding (HP:0000225)6.10421782
11Hyperlipoproteinemia (HP:0010980)5.24907133
12Impaired platelet aggregation (HP:0003540)5.07286240
13Abnormal platelet function (HP:0011869)5.07286240
14Parakeratosis (HP:0001036)4.69691044
15Sensory axonal neuropathy (HP:0003390)4.68766287
16Cerebral inclusion bodies (HP:0100314)4.64861277
17Abnormality of the corticospinal tract (HP:0002492)4.64017493
18Peripheral hypomyelination (HP:0007182)4.54856149
19Cerebral hypomyelination (HP:0006808)4.18683377
20Spontaneous hematomas (HP:0007420)4.01467194
21Onion bulb formation (HP:0003383)3.96777732
22Abnormal auditory evoked potentials (HP:0006958)3.83441109
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.77472109
24Poikilocytosis (HP:0004447)3.69550472
25Supranuclear gaze palsy (HP:0000605)3.68140100
26Acanthocytosis (HP:0001927)3.46963350
27Spastic gait (HP:0002064)3.41549539
28Abnormality of binocular vision (HP:0011514)3.37030743
29Diplopia (HP:0000651)3.37030743
30Alacrima (HP:0000522)3.33459310
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.25506812
32Intention tremor (HP:0002080)3.18264538
33Dyschromatopsia (HP:0007641)3.17697162
34Abnormality of the heme biosynthetic pathway (HP:0010472)3.13402224
35Dysmetria (HP:0001310)3.12453885
36Leukodystrophy (HP:0002415)3.09552128
37Hypoplastic pelvis (HP:0008839)3.05862136
38Slow saccadic eye movements (HP:0000514)3.03161344
39Bruising susceptibility (HP:0000978)3.02958455
40Segmental peripheral demyelination/remyelination (HP:0003481)2.97793261
41Ventricular fibrillation (HP:0001663)2.93532993
42Conjunctival telangiectasia (HP:0000524)2.91018149
43Myokymia (HP:0002411)2.88208080
44Insidious onset (HP:0003587)2.84597356
45Termporal pattern (HP:0011008)2.84597356
46Abnormal pupillary function (HP:0007686)2.83879482
47Increased serum pyruvate (HP:0003542)2.82667669
48Abnormality of glycolysis (HP:0004366)2.82667669
49Anteriorly placed anus (HP:0001545)2.79667253
50Spastic paraparesis (HP:0002313)2.78598926
51Ankle clonus (HP:0011448)2.75376839
52Scanning speech (HP:0002168)2.74202610
53Congenital ichthyosiform erythroderma (HP:0007431)2.74052490
54Abnormality of the common coagulation pathway (HP:0010990)2.71532822
55Increased density of long bones (HP:0006392)2.68484933
56Decreased lacrimation (HP:0000633)2.64763815
57Retinal dysplasia (HP:0007973)2.64584554
58Absent septum pellucidum (HP:0001331)2.64231713
59CNS hypomyelination (HP:0003429)2.59862309
60Aplasia involving bones of the extremities (HP:0009825)2.59368402
61Aplasia involving bones of the upper limbs (HP:0009823)2.59368402
62Aplasia of the phalanges of the hand (HP:0009802)2.59368402
63Abnormality of lateral ventricle (HP:0030047)2.56393116
64Split foot (HP:0001839)2.55749778
65Clumsiness (HP:0002312)2.53897457
66Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53128455
67Paralysis (HP:0003470)2.52326922
68Morphological abnormality of the inner ear (HP:0011390)2.48144981
69Akinesia (HP:0002304)2.47702724
70Abnormality of macrophages (HP:0004311)2.45640347
71Thickened helices (HP:0000391)2.43992113
72Premature skin wrinkling (HP:0100678)2.42832463
73Stridor (HP:0010307)2.38922129
74Megalencephaly (HP:0001355)2.37056335
75Bundle branch block (HP:0011710)2.36239344
76Stomatitis (HP:0010280)2.30096863
77Autoamputation (HP:0001218)2.28600912
78Methylmalonic acidemia (HP:0002912)2.26961725
79Visual hallucinations (HP:0002367)2.22942922
80Abnormality of the septum pellucidum (HP:0007375)2.22585098
81Axonal loss (HP:0003447)2.22126403
82White forelock (HP:0002211)2.20930368
83Hepatosplenomegaly (HP:0001433)2.20448203
84Spastic tetraparesis (HP:0001285)2.20106993
85Paraparesis (HP:0002385)2.18492956
86Synostosis involving the elbow (HP:0003938)2.18279101
87Humeroradial synostosis (HP:0003041)2.18279101
88Episodic fever (HP:0001954)2.16979735
89Pheochromocytoma (HP:0002666)2.16834937
90Patchy hypopigmentation of hair (HP:0011365)2.15447405
91Coronal craniosynostosis (HP:0004440)2.15402553
92Febrile seizures (HP:0002373)2.14726627
93Foot dorsiflexor weakness (HP:0009027)2.14341309
94Increased circulating renin level (HP:0000848)2.13998005
95Cerebral hemorrhage (HP:0001342)2.12590931
96Abnormality of the phalanges of the 2nd finger (HP:0009541)2.12192405
97Infantile muscular hypotonia (HP:0008947)2.12188680
98Metabolic alkalosis (HP:0200114)2.10424860
99Hyperthyroidism (HP:0000836)2.08540838
100Hypoplasia of the iris (HP:0007676)2.05046248
101Joint swelling (HP:0001386)2.04699712
102Poor speech (HP:0002465)2.04243731
103Muscle fiber splitting (HP:0003555)2.03850395
104Joint hemorrhage (HP:0005261)2.03486447
105Xanthomatosis (HP:0000991)2.03294078
106Upper limb muscle weakness (HP:0003484)2.00846556
107Atonic seizures (HP:0010819)2.00695153
108Prolonged bleeding time (HP:0003010)10.9361821
109Distal lower limb amyotrophy (HP:0008944)1.99962953
110Lower limb amyotrophy (HP:0007210)1.99955308
111Decreased motor nerve conduction velocity (HP:0003431)1.99780890
112Lower limb muscle weakness (HP:0007340)1.99765220
113Gowers sign (HP:0003391)1.97670388
114Hypomagnesemia (HP:0002917)1.96443866
115Chronic obstructive pulmonary disease (HP:0006510)1.96048069
116Obstructive lung disease (HP:0006536)1.96048069
117Decreased central vision (HP:0007663)1.94540890
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94359543
119Abnormality of the foot musculature (HP:0001436)1.93703906
120Vertigo (HP:0002321)1.91760496
121Increased IgM level (HP:0003496)1.90831254
122Abnormality of the middle phalanges of the toes (HP:0010183)1.90291337
123Polyphagia (HP:0002591)1.89948085
124Partial duplication of thumb phalanx (HP:0009944)1.88156454
125Hypokalemic alkalosis (HP:0001949)1.87994024
126Abnormal eating behavior (HP:0100738)1.87704505
127Urinary incontinence (HP:0000020)1.86925568
1283-Methylglutaconic aciduria (HP:0003535)1.86271174
129Neuroendocrine neoplasm (HP:0100634)1.85708089
130Partial agenesis of the corpus callosum (HP:0001338)1.84842255
131Peripheral demyelination (HP:0011096)1.83489944
132Myelomeningocele (HP:0002475)1.82712468
133Bowel incontinence (HP:0002607)1.81605651
134Septo-optic dysplasia (HP:0100842)1.81173374
135Eczematoid dermatitis (HP:0000976)1.80371394
136Cupped ear (HP:0000378)1.80196787
137Vaginal atresia (HP:0000148)1.79763691
138Adrenal hypoplasia (HP:0000835)1.79485222
139Encephalitis (HP:0002383)1.78862743
140Prolonged neonatal jaundice (HP:0006579)1.78119565
141Hyporeflexia of lower limbs (HP:0002600)1.77943741
142Dysautonomia (HP:0002459)1.75684903
143Choreoathetosis (HP:0001266)1.74273312
144Abnormality of iron homeostasis (HP:0011031)1.73619840
145Polycythemia (HP:0001901)1.72556528
146Clonus (HP:0002169)1.71621754
147Mixed hearing impairment (HP:0000410)1.71402275
148Action tremor (HP:0002345)1.71212086
149Distal sensory impairment (HP:0002936)1.70513645
150Abnormal large intestine physiology (HP:0012700)1.69594938
151Tinnitus (HP:0000360)1.69264794
152Renal Fanconi syndrome (HP:0001994)1.68034974
153Genital tract atresia (HP:0001827)1.67849479
154Esophageal atresia (HP:0002032)1.65708345
155Male infertility (HP:0003251)1.65113061
156Arterial thrombosis (HP:0004420)1.64958617
157Barrel-shaped chest (HP:0001552)1.64328184
158Abolished electroretinogram (ERG) (HP:0000550)1.63332812
159Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.62838188
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60526278
161Heart block (HP:0012722)1.57622861
162Muscle fibrillation (HP:0010546)1.55416808
163Papillary thyroid carcinoma (HP:0002895)1.52418608
164Impaired vibration sensation in the lower limbs (HP:0002166)1.52380918
165Postural instability (HP:0002172)1.49931293
166Spontaneous abortion (HP:0005268)1.49908716
167Hemiplegia (HP:0002301)1.49615294
168Abnormal atrioventricular conduction (HP:0005150)1.49455607
169Papilledema (HP:0001085)1.48367200
170Focal motor seizures (HP:0011153)1.48287711
171Urinary bladder sphincter dysfunction (HP:0002839)1.47070874
172Pulmonary embolism (HP:0002204)1.46933091
173Basal ganglia calcification (HP:0002135)1.46554798
174Delusions (HP:0000746)1.45092973
175Testicular neoplasm (HP:0010788)1.44609063
176Truncus arteriosus (HP:0001660)1.43616657
177Recurrent abscess formation (HP:0002722)1.43285622
178Tongue fasciculations (HP:0001308)1.41624824
179Abnormality of transition element cation homeostasis (HP:0011030)1.41622158
180Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.41445560
181Chest pain (HP:0100749)1.39288301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.03345522
2RIPK45.99056521
3OXSR14.25106124
4MYLK3.29912386
5EPHB12.94439380
6PKN12.85595752
7PBK2.65830692
8BCR2.64653199
9MAPKAPK52.57612360
10BTK2.46185783
11MET2.41709563
12TEC2.39458628
13PRPF4B2.37066898
14WNK42.35195359
15GRK52.32703790
16TNIK2.24032641
17LIMK12.16804173
18FGFR22.06576711
19EIF2AK12.06213508
20SYK2.04292918
21CDK192.01787551
22DAPK22.01565279
23TNK21.98761393
24FES1.95762707
25CSNK1G31.89183536
26ILK1.87812239
27WNK11.85880008
28NEK61.84474102
29CSNK1A1L1.84191778
30BMPR21.83718347
31UHMK11.76755559
32ZAP701.75054807
33PNCK1.64046975
34GRK61.61188431
35TESK21.58316789
36CASK1.56742548
37CAMK2B1.53392643
38CSF1R1.51791649
39ROCK21.51534517
40CSNK1G11.49116558
41NTRK31.49009263
42FGR1.47368840
43DAPK31.45079377
44CLK11.44816285
45CSNK1G21.43761023
46MUSK1.43393978
47NTRK11.40875906
48SGK2231.38851557
49SGK4941.38851557
50PLK21.38733534
51BLK1.38688143
52EPHA41.35882002
53HCK1.34789711
54TAOK31.33098318
55MAP2K31.31462379
56MST41.27491841
57CAMK2D1.25209782
58ICK1.24019386
59MINK11.21720810
60PIK3CG1.16423089
61LMTK21.14864305
62PHKG21.14449077
63PHKG11.14449077
64MAPK121.13573349
65DYRK21.11567740
66PAK61.05357820
67MARK11.03370389
68CAMK2G1.01878286
69MAP3K111.01456776
70RET0.97314983
71MAPK150.97253763
72CSK0.91979817
73LYN0.90590445
74TYRO30.87042124
75TAOK20.85588914
76PRKCQ0.85100006
77MARK20.84432828
78CAMK2A0.84208197
79BMPR1B0.84164414
80CDK140.83932057
81TAOK10.82000610
82PAK30.80153948
83MAP3K50.79909553
84ERBB20.79333908
85CDK50.76692260
86PRKD10.76262746
87TRPM70.75504048
88SIK30.74797812
89CDK150.74734394
90CAMK10.74707213
91MAPKAPK30.71876381
92IRAK20.71445480
93SGK20.70438791
94NTRK20.70391748
95STK30.70340680
96CDK180.69235333
97PRKCE0.67164181
98CDK11A0.66410627
99STK240.62885379
100MAPK130.62859553
101DAPK10.62588231
102CAMKK10.62543381
103SGK30.62400944
104JAK20.62284026
105MATK0.61180595
106ADRBK10.60276922
107PRKACG0.58355028
108PDPK10.56968024
109CAMKK20.56327836
110RPS6KA50.55036955
111MAP2K10.54871038
112MAP3K30.54582777
113IKBKB0.54453456
114MAP3K10.53715049
115FYN0.53403146
116MAP2K20.52947883
117GRK70.51116283
118CSNK1D0.50747227
119ARAF0.50171883
120PRKG10.49232247
121PIM20.46894992
122MKNK10.46701637
123PRKCH0.46489221
124TXK0.46480799
125CSNK1A10.46384687
126MAP3K130.46176696
127JAK10.46088511
128PINK10.45734998
129CAMK1G0.45485925
130DMPK0.44693149
131ADRBK20.44593032
132MAPK70.44399117
133KSR20.43802321
134PRKD30.43291829
135GSK3A0.42256890
136IRAK10.41976895
137MARK30.41695754
138PRKACB0.41416766
139ERBB40.40678824
140BMX0.37463460
141PIK3CA0.34273265
142DYRK1A0.33919494
143OBSCN0.32724711
144GRK10.31167431
145PRKACA0.30899413
146PAK10.30447264
147ITK0.29339945
148INSR0.26126253
149ROCK10.25824019
150STK110.25802367
151PTK2B0.25411466
152PDK10.24217984
153STK160.23394499
154MAPK100.23185769
155DDR20.23167590
156PRKD20.22944844
157PDGFRB0.22836799

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.21544951
2Steroid biosynthesis_Homo sapiens_hsa001004.83397468
3Fatty acid elongation_Homo sapiens_hsa000624.44346264
4Platelet activation_Homo sapiens_hsa046114.39987575
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.34961042
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.14166180
7Ether lipid metabolism_Homo sapiens_hsa005653.10281272
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82436823
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.43264099
10Vitamin B6 metabolism_Homo sapiens_hsa007502.14573086
11Nitrogen metabolism_Homo sapiens_hsa009102.09822968
12Sulfur metabolism_Homo sapiens_hsa009202.03441252
13Oxidative phosphorylation_Homo sapiens_hsa001901.97145649
14Protein export_Homo sapiens_hsa030601.81407238
15Histidine metabolism_Homo sapiens_hsa003401.79291779
16Sphingolipid metabolism_Homo sapiens_hsa006001.78510400
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77506987
18Linoleic acid metabolism_Homo sapiens_hsa005911.77487354
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74186416
20Chemokine signaling pathway_Homo sapiens_hsa040621.69567722
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69008827
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63773264
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62370814
24Hematopoietic cell lineage_Homo sapiens_hsa046401.61575973
25Axon guidance_Homo sapiens_hsa043601.56992917
26Parkinsons disease_Homo sapiens_hsa050121.41421606
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40763626
28Long-term potentiation_Homo sapiens_hsa047201.39134057
29Butanoate metabolism_Homo sapiens_hsa006501.37182481
30Alzheimers disease_Homo sapiens_hsa050101.33810448
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33093174
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32774459
33Arginine and proline metabolism_Homo sapiens_hsa003301.29963885
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22095202
35Glutamatergic synapse_Homo sapiens_hsa047241.19235173
36GABAergic synapse_Homo sapiens_hsa047271.16007787
37B cell receptor signaling pathway_Homo sapiens_hsa046621.15754410
38Serotonergic synapse_Homo sapiens_hsa047261.11922477
39Calcium signaling pathway_Homo sapiens_hsa040201.10819250
40Rap1 signaling pathway_Homo sapiens_hsa040151.08825044
41Alcoholism_Homo sapiens_hsa050341.06669883
42Olfactory transduction_Homo sapiens_hsa047401.06611437
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05635139
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04739502
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03540500
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.03383883
47Dilated cardiomyopathy_Homo sapiens_hsa054141.02287241
48Fatty acid metabolism_Homo sapiens_hsa012121.00148383
49Amphetamine addiction_Homo sapiens_hsa050310.99909183
50Oxytocin signaling pathway_Homo sapiens_hsa049210.99138436
51Arachidonic acid metabolism_Homo sapiens_hsa005900.97314478
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96765958
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94853335
54Fatty acid biosynthesis_Homo sapiens_hsa000610.94705543
55Osteoclast differentiation_Homo sapiens_hsa043800.92795523
56Choline metabolism in cancer_Homo sapiens_hsa052310.92636032
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91445897
58Morphine addiction_Homo sapiens_hsa050320.90566421
59Long-term depression_Homo sapiens_hsa047300.90245095
60Shigellosis_Homo sapiens_hsa051310.89980541
61Renal cell carcinoma_Homo sapiens_hsa052110.89602415
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85664092
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84025206
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83719004
65Insulin secretion_Homo sapiens_hsa049110.81963185
66Glutathione metabolism_Homo sapiens_hsa004800.81704530
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.81448570
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.80868403
69Glioma_Homo sapiens_hsa052140.80789478
70Tight junction_Homo sapiens_hsa045300.79643862
71Cocaine addiction_Homo sapiens_hsa050300.79515438
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78466493
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78219585
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76731137
75Cardiac muscle contraction_Homo sapiens_hsa042600.76720779
76T cell receptor signaling pathway_Homo sapiens_hsa046600.76685046
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76684022
78Focal adhesion_Homo sapiens_hsa045100.74145862
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74077595
80Propanoate metabolism_Homo sapiens_hsa006400.73817534
81GnRH signaling pathway_Homo sapiens_hsa049120.72687068
82Mineral absorption_Homo sapiens_hsa049780.72229441
83Vibrio cholerae infection_Homo sapiens_hsa051100.71544679
84Collecting duct acid secretion_Homo sapiens_hsa049660.71344129
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71188380
86VEGF signaling pathway_Homo sapiens_hsa043700.69748453
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68354725
88Ovarian steroidogenesis_Homo sapiens_hsa049130.68273526
89Lysosome_Homo sapiens_hsa041420.67578331
90Autoimmune thyroid disease_Homo sapiens_hsa053200.65792121
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.65778806
92Huntingtons disease_Homo sapiens_hsa050160.64771734
93Peroxisome_Homo sapiens_hsa041460.64071322
94Endometrial cancer_Homo sapiens_hsa052130.63388332
95Non-small cell lung cancer_Homo sapiens_hsa052230.63197234
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.62859629
97Salivary secretion_Homo sapiens_hsa049700.60947852
98Phototransduction_Homo sapiens_hsa047440.60038402
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.59551659
100Endocytosis_Homo sapiens_hsa041440.59189329
101Rheumatoid arthritis_Homo sapiens_hsa053230.59085405
102Circadian entrainment_Homo sapiens_hsa047130.58657978
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58540954
104Pancreatic cancer_Homo sapiens_hsa052120.57836939
105Bile secretion_Homo sapiens_hsa049760.57766336
106Nicotine addiction_Homo sapiens_hsa050330.57324043
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56695725
108Ras signaling pathway_Homo sapiens_hsa040140.56600873
109Vitamin digestion and absorption_Homo sapiens_hsa049770.54684306
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54074159
111MAPK signaling pathway_Homo sapiens_hsa040100.54041841
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53985273
113Amoebiasis_Homo sapiens_hsa051460.53412021
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53085114
115Gastric acid secretion_Homo sapiens_hsa049710.52713364
116Malaria_Homo sapiens_hsa051440.51750534
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.51257770
118Pancreatic secretion_Homo sapiens_hsa049720.50684940
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50047978
120Dorso-ventral axis formation_Homo sapiens_hsa043200.49833340
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48127611
122Metabolic pathways_Homo sapiens_hsa011000.47787699
123Estrogen signaling pathway_Homo sapiens_hsa049150.46861831
124Systemic lupus erythematosus_Homo sapiens_hsa053220.46265226
125Salmonella infection_Homo sapiens_hsa051320.45962298
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45699063
127Staphylococcus aureus infection_Homo sapiens_hsa051500.45192323
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44631571
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44420051
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43915987
131Hedgehog signaling pathway_Homo sapiens_hsa043400.43537377
132Folate biosynthesis_Homo sapiens_hsa007900.42575473
133Inositol phosphate metabolism_Homo sapiens_hsa005620.41976431
134Phagosome_Homo sapiens_hsa041450.41506356
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.40571340
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39569126
137Tuberculosis_Homo sapiens_hsa051520.38962241
138Chemical carcinogenesis_Homo sapiens_hsa052040.38833257
139Cholinergic synapse_Homo sapiens_hsa047250.36065604
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36025526
141Gap junction_Homo sapiens_hsa045400.33753472
142ErbB signaling pathway_Homo sapiens_hsa040120.33742719
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33195162
144Dopaminergic synapse_Homo sapiens_hsa047280.32772020
145Glycerolipid metabolism_Homo sapiens_hsa005610.31622854
146Retinol metabolism_Homo sapiens_hsa008300.31597636
147ECM-receptor interaction_Homo sapiens_hsa045120.30843261
148Taste transduction_Homo sapiens_hsa047420.29770331
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28362000
150Renin secretion_Homo sapiens_hsa049240.27579717
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27403455
152Synaptic vesicle cycle_Homo sapiens_hsa047210.26349549
153cAMP signaling pathway_Homo sapiens_hsa040240.26306971
154Tyrosine metabolism_Homo sapiens_hsa003500.24636163
155beta-Alanine metabolism_Homo sapiens_hsa004100.23789269
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23650757
157Pyruvate metabolism_Homo sapiens_hsa006200.23451314

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