CMTM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.01670286
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01670286
3response to peptidoglycan (GO:0032494)4.61999407
4detection of molecule of bacterial origin (GO:0032490)4.60037147
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.57103533
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57103533
7detection of other organism (GO:0098543)4.36153228
8antigen processing and presentation of endogenous antigen (GO:0019883)4.26977786
9negative regulation of interleukin-12 production (GO:0032695)4.18121898
10detection of external biotic stimulus (GO:0098581)4.05819920
11neutrophil activation (GO:0042119)4.03028200
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.96099591
13detection of bacterium (GO:0016045)3.88334684
14granulocyte activation (GO:0036230)3.86820174
15alpha-linolenic acid metabolic process (GO:0036109)3.59729206
16detection of biotic stimulus (GO:0009595)3.59320596
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58978112
18production of molecular mediator involved in inflammatory response (GO:0002532)3.58563515
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50642127
20urea metabolic process (GO:0019627)3.48668479
21urea cycle (GO:0000050)3.48668479
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46656521
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44007677
24response to host immune response (GO:0052572)3.44007677
25myeloid cell activation involved in immune response (GO:0002275)3.39872687
26valine metabolic process (GO:0006573)3.39202239
27cysteine metabolic process (GO:0006534)3.37075786
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.35368413
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34624096
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34570820
31L-phenylalanine catabolic process (GO:0006559)3.34570820
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.33227926
33L-phenylalanine metabolic process (GO:0006558)3.31794422
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31794422
35response to interleukin-15 (GO:0070672)3.31242257
36regulation of tolerance induction (GO:0002643)3.30081379
37sulfur amino acid catabolic process (GO:0000098)3.27962703
38protein carboxylation (GO:0018214)3.27894948
39peptidyl-glutamic acid carboxylation (GO:0017187)3.27894948
40respiratory burst (GO:0045730)3.27365464
41complement activation, alternative pathway (GO:0006957)3.27255438
42macrophage activation (GO:0042116)3.26524220
43aromatic amino acid family catabolic process (GO:0009074)3.25382672
44positive regulation of gamma-delta T cell activation (GO:0046645)3.22202668
45response to host (GO:0075136)3.20719032
46response to host defenses (GO:0052200)3.20719032
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.20719032
48response to muramyl dipeptide (GO:0032495)3.19391463
49leukocyte aggregation (GO:0070486)3.18824859
50positive regulation of mast cell activation (GO:0033005)3.18132586
51nitrogen cycle metabolic process (GO:0071941)3.17702192
52regulation of mast cell degranulation (GO:0043304)3.16812753
53indole-containing compound catabolic process (GO:0042436)3.16438789
54indolalkylamine catabolic process (GO:0046218)3.16438789
55tryptophan catabolic process (GO:0006569)3.16438789
56regulation of interferon-beta biosynthetic process (GO:0045357)3.15783140
57urate metabolic process (GO:0046415)3.14168316
58B cell mediated immunity (GO:0019724)3.12070952
59cellular response to interleukin-15 (GO:0071350)3.11877261
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09025011
61dendritic cell migration (GO:0036336)3.08290826
62regulation of T cell tolerance induction (GO:0002664)3.07019737
63neutrophil mediated immunity (GO:0002446)3.05793940
64dendritic cell chemotaxis (GO:0002407)3.03957433
65kynurenine metabolic process (GO:0070189)3.02179204
66interferon-gamma-mediated signaling pathway (GO:0060333)3.01401341
67tryptophan metabolic process (GO:0006568)3.01175019
68negative regulation of T cell mediated immunity (GO:0002710)3.00336215
69negative regulation of leukocyte mediated immunity (GO:0002704)2.99901678
70glyoxylate metabolic process (GO:0046487)2.99477195
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.99358186
72leukocyte migration involved in inflammatory response (GO:0002523)2.95340992
73regulation of protein activation cascade (GO:2000257)2.95015095
74cellular response to type I interferon (GO:0071357)2.94764037
75type I interferon signaling pathway (GO:0060337)2.94764037
76positive regulation of tolerance induction (GO:0002645)2.94559716
77regulation of mast cell activation (GO:0033003)2.92902857
78regulation of mast cell activation involved in immune response (GO:0033006)2.92439621
79regulation of gamma-delta T cell differentiation (GO:0045586)2.91950129
80leukocyte degranulation (GO:0043299)2.91751177
81regulation of cholesterol homeostasis (GO:2000188)2.90385910
82lysine catabolic process (GO:0006554)2.90182838
83lysine metabolic process (GO:0006553)2.90182838
84regulation of leukocyte degranulation (GO:0043300)2.90167044
85positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90116544
86response to type I interferon (GO:0034340)2.90034009
87positive regulation of interferon-alpha production (GO:0032727)2.89560669
88positive regulation by symbiont of host defense response (GO:0052509)2.89101736
89modulation by symbiont of host defense response (GO:0052031)2.89101736
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89101736
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89101736
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.89101736
93modulation by symbiont of host immune response (GO:0052553)2.89101736
94positive regulation of cellular amide metabolic process (GO:0034250)2.88496758
95regulation of complement activation (GO:0030449)2.87141736
96T-helper 1 type immune response (GO:0042088)2.86840530
97regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86499285
98bile acid biosynthetic process (GO:0006699)2.85003440
99regulation of triglyceride catabolic process (GO:0010896)2.84860749
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80631087
101phospholipid efflux (GO:0033700)2.80363658
102JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.79440237
103Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78726136
104regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77366370
105regulation of B cell differentiation (GO:0045577)2.77353682
106tolerance induction (GO:0002507)2.76805587
107negative regulation of interleukin-17 production (GO:0032700)2.76417693
108T cell migration (GO:0072678)2.76358876
109positive regulation of mast cell degranulation (GO:0043306)2.76136956
110positive regulation of mast cell activation involved in immune response (GO:0033008)2.76136956
111myeloid leukocyte activation (GO:0002274)2.75804442
112homocysteine metabolic process (GO:0050667)2.74838775
113serine family amino acid catabolic process (GO:0009071)2.74228037
114growth hormone receptor signaling pathway (GO:0060396)2.72847845
115ethanol oxidation (GO:0006069)2.71845240
116regulation of interferon-alpha production (GO:0032647)2.71626285
117regulation of gamma-delta T cell activation (GO:0046643)2.70714086
118regulation of alpha-beta T cell proliferation (GO:0046640)2.70621902
119positive regulation of leukocyte degranulation (GO:0043302)2.70373206
120regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70371007
121macrophage activation involved in immune response (GO:0002281)2.70332677
122drug transmembrane transport (GO:0006855)2.69932395
123negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69825255
124defense response to protozoan (GO:0042832)2.69426183
125B cell receptor signaling pathway (GO:0050853)2.67914852
126amino-acid betaine metabolic process (GO:0006577)2.67800154
127negative thymic T cell selection (GO:0045060)2.64959676
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64758602
129positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64224281
130positive regulation of type 2 immune response (GO:0002830)2.63981270
131negative T cell selection (GO:0043383)2.63135125
132positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62732040
133negative regulation of cholesterol transport (GO:0032375)2.62583802
134negative regulation of sterol transport (GO:0032372)2.62583802
135negative regulation of fibrinolysis (GO:0051918)2.62472975
136regulation of T cell mediated cytotoxicity (GO:0001914)2.62311177
137phospholipid homeostasis (GO:0055091)2.61415633
138low-density lipoprotein particle clearance (GO:0034383)2.61140010
139complement activation, classical pathway (GO:0006958)2.60904745
140high-density lipoprotein particle remodeling (GO:0034375)2.57220737
141regulation of cholesterol storage (GO:0010885)2.57147954
142plasma lipoprotein particle clearance (GO:0034381)2.55274444
143bile acid and bile salt transport (GO:0015721)2.54391872
144complement activation (GO:0006956)2.53260393
145positive regulation of B cell differentiation (GO:0045579)2.52395241
146reverse cholesterol transport (GO:0043691)2.50081044
147positive regulation of antigen processing and presentation (GO:0002579)2.49967445
148bile acid metabolic process (GO:0008206)2.48428902
149drug transport (GO:0015893)2.46011628
150ethanol metabolic process (GO:0006067)2.43457575
151negative regulation of granulocyte differentiation (GO:0030853)2.41695897
152regulation of interleukin-12 biosynthetic process (GO:0045075)2.40835608
153immunoglobulin mediated immune response (GO:0016064)2.38989249
154regulation of B cell receptor signaling pathway (GO:0050855)2.37766726
1552-oxoglutarate metabolic process (GO:0006103)2.36524987
156plasma lipoprotein particle assembly (GO:0034377)2.35804608
157response to growth hormone (GO:0060416)2.35038726
158acute-phase response (GO:0006953)2.34934420
159regulation of fibrinolysis (GO:0051917)2.34499380
160positive regulation of lipoprotein lipase activity (GO:0051006)2.33020003
161positive regulation of triglyceride lipase activity (GO:0061365)2.33020003
162cellular modified amino acid catabolic process (GO:0042219)2.32618766
163protein-lipid complex assembly (GO:0065005)2.32305648
164antigen processing and presentation via MHC class Ib (GO:0002475)2.31785234
165cellular response to growth hormone stimulus (GO:0071378)2.30716989
166neutrophil activation involved in immune response (GO:0002283)2.29430605
167positive regulation of natural killer cell differentiation (GO:0032825)2.28676206
168serine family amino acid metabolic process (GO:0009069)2.28603130
169primary alcohol catabolic process (GO:0034310)2.28051237
170tricarboxylic acid metabolic process (GO:0072350)2.27702603
171response to laminar fluid shear stress (GO:0034616)2.27465480
172glycine metabolic process (GO:0006544)2.26539628
173aromatic amino acid family metabolic process (GO:0009072)2.26282690
174cellular extravasation (GO:0045123)2.26133707
175microglial cell activation (GO:0001774)2.25813383
176cholesterol homeostasis (GO:0042632)2.25667478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.13125855
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.83295249
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.80943304
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.67882801
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.09036746
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.03180718
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02013154
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.92295759
9* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.69952302
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.68290372
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66753869
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59206461
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.49900210
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.45635589
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45623738
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43934614
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32360526
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.30997746
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.30962698
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30649570
21* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21294175
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19248977
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17910035
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16847349
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10049136
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09270410
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05338916
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04211859
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.84809846
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83937617
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83057358
32CLOCK_20551151_ChIP-Seq_293T_Human1.81765103
33VDR_24787735_ChIP-Seq_THP-1_Human1.77126204
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69375740
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68675779
36GATA1_22025678_ChIP-Seq_K562_Human1.68485545
37MYC_22102868_ChIP-Seq_BL_Human1.67059263
38MAF_26560356_Chip-Seq_TH1_Human1.65728683
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63197289
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61983556
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61763748
42VDR_21846776_ChIP-Seq_THP-1_Human1.58765928
43MYB_26560356_Chip-Seq_TH2_Human1.55066910
44RUNX_20019798_ChIP-Seq_JUKART_Human1.54862955
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54499649
46SCL_19346495_ChIP-Seq_HPC-7_Human1.54431866
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51190353
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48778298
49GATA3_26560356_Chip-Seq_TH2_Human1.48428429
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47991365
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47509110
52MYB_26560356_Chip-Seq_TH1_Human1.45809942
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43986908
54TCF7_22412390_ChIP-Seq_EML_Mouse1.42637402
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38365107
56* SPI1_23547873_ChIP-Seq_NB4_Human1.37095402
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.30271992
58* RUNX1_22412390_ChIP-Seq_EML_Mouse1.29935424
59UTX_26944678_Chip-Seq_JUKART_Human1.28455965
60VDR_24763502_ChIP-Seq_THP-1_Human1.26276481
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26146061
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.24767123
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19082269
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19018423
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18570908
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17304556
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17089359
68TFEB_21752829_ChIP-Seq_HELA_Human1.16282011
69* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16235283
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15763156
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15755337
72* FOXO3_23340844_ChIP-Seq_DLD1_Human1.15502332
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11781921
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10498681
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10270552
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10062047
77GATA4_25053715_ChIP-Seq_YYC3_Human1.09524285
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09512879
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09420942
80PU_27001747_Chip-Seq_BMDM_Mouse1.09393533
81* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09370310
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.09007992
83SPI1_23127762_ChIP-Seq_K562_Human1.08841798
84* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08410409
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07880569
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07179291
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07170066
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07060785
89ZNF263_19887448_ChIP-Seq_K562_Human1.05208972
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05070789
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05021068
92LXR_22292898_ChIP-Seq_THP-1_Human1.04510916
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03953256
94GATA3_27048872_Chip-Seq_THYMUS_Human1.02649159
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00462678
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99027566
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98700476
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98700476
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97813453
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97657425
101RACK7_27058665_Chip-Seq_MCF-7_Human0.97499615
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.97336581
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96784865
104MAF_26560356_Chip-Seq_TH2_Human0.96395955
105* GATA6_25053715_ChIP-Seq_YYC3_Human0.95954640
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95873656
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95599485
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95339179
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94853674
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94697235
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92602288
112* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92282549
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.92067009
114* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91564591
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91561467
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90955574
117KDM2B_26808549_Chip-Seq_DND41_Human0.90266608
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89216229
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88271626
120GATA1_19941826_ChIP-Seq_K562_Human0.88251800
121GATA2_19941826_ChIP-Seq_K562_Human0.86631806
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85956591
123* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85488855
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85206150
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85108287
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82580111
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82173938
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78219020
129* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76968768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.76287123
2MP0002139_abnormal_hepatobiliary_system3.52258762
3MP0005085_abnormal_gallbladder_physiolo2.91939914
4MP0009840_abnormal_foam_cell2.77223653
5MP0003191_abnormal_cellular_cholesterol2.74315696
6MP0005365_abnormal_bile_salt2.69552184
7MP0001835_abnormal_antigen_presentation2.63897000
8MP0003436_decreased_susceptibility_to2.42433786
9MP0002138_abnormal_hepatobiliary_system2.24908681
10MP0003300_gastrointestinal_ulcer2.19771287
11MP0003252_abnormal_bile_duct2.18486715
12MP0006082_CNS_inflammation2.10322338
13MP0003303_peritoneal_inflammation2.06949020
14MP0000685_abnormal_immune_system2.06220024
15MP0008875_abnormal_xenobiotic_pharmacok1.96432874
16MP0002254_reproductive_system_inflammat1.95662323
17MP0005058_abnormal_lysosome_morphology1.91567800
18MP0003828_pulmonary_edema1.90319816
19MP0008260_abnormal_autophagy1.79253240
20MP0003724_increased_susceptibility_to1.78950829
21MP0009785_altered_susceptibility_to1.78040613
22MP0001790_abnormal_immune_system1.73655628
23MP0005387_immune_system_phenotype1.73655628
24MP0010329_abnormal_lipoprotein_level1.73577982
25MP0005671_abnormal_response_to1.72519804
26MP0001800_abnormal_humoral_immune1.71447986
27MP0003806_abnormal_nucleotide_metabolis1.71173482
28MP0002419_abnormal_innate_immunity1.70385898
29MP0010234_abnormal_vibrissa_follicle1.69690656
30MP0005025_abnormal_response_to1.69471525
31MP0004947_skin_inflammation1.64827786
32MP0000609_abnormal_liver_physiology1.62673085
33MP0005000_abnormal_immune_tolerance1.61899032
34MP0004019_abnormal_vitamin_homeostasis1.58705448
35MP0002452_abnormal_antigen_presenting1.57643531
36MP0002166_altered_tumor_susceptibility1.57058788
37MP0003705_abnormal_hypodermis_morpholog1.55484968
38MP0001666_abnormal_nutrient_absorption1.55296890
39MP0005464_abnormal_platelet_physiology1.54779784
40MP0002148_abnormal_hypersensitivity_rea1.51862746
41MP0002877_abnormal_melanocyte_morpholog1.51007013
42MP0002723_abnormal_immune_serum1.50358785
43MP0001853_heart_inflammation1.49719832
44MP0010155_abnormal_intestine_physiology1.46151871
45MP0005332_abnormal_amino_acid1.45663478
46MP0008469_abnormal_protein_level1.43375535
47MP0001845_abnormal_inflammatory_respons1.42786619
48MP0005451_abnormal_body_composition1.40148294
49MP0008004_abnormal_stomach_pH1.38403527
50MP0001873_stomach_inflammation1.37307535
51MP0009643_abnormal_urine_homeostasis1.37307191
52MP0005083_abnormal_biliary_tract1.36572641
53MP0001819_abnormal_immune_cell1.35788514
54MP0002998_abnormal_bone_remodeling1.34727752
55MP0002420_abnormal_adaptive_immunity1.33987219
56MP0005164_abnormal_response_to1.29679241
57MP0010352_gastrointestinal_tract_polyps1.29548294
58MP0004883_abnormal_blood_vessel1.29060536
59MP0001533_abnormal_skeleton_physiology1.27709353
60MP0009278_abnormal_bone_marrow1.27563882
61MP0003566_abnormal_cell_adhesion1.24128466
62MP0009764_decreased_sensitivity_to1.23281109
63MP0002132_abnormal_respiratory_system1.22618008
64MP0002405_respiratory_system_inflammati1.21989744
65MP0003656_abnormal_erythrocyte_physiolo1.21719965
66MP0003453_abnormal_keratinocyte_physiol1.19759138
67MP0005319_abnormal_enzyme/_coenzyme1.19352708
68MP0003763_abnormal_thymus_physiology1.16100842
69MP0002118_abnormal_lipid_homeostasis1.13310077
70MP0002796_impaired_skin_barrier1.12511243
71MP0002006_tumorigenesis1.12373660
72MP0001881_abnormal_mammary_gland1.09915387
73MP0000716_abnormal_immune_system1.09853428
74MP0000703_abnormal_thymus_morphology1.06271217
75MP0002136_abnormal_kidney_physiology1.05958440
76MP0002277_abnormal_respiratory_mucosa1.05099626
77MP0000689_abnormal_spleen_morphology1.05016476
78MP0003172_abnormal_lysosome_physiology1.04651323
79MP0005023_abnormal_wound_healing1.04188764
80MP0002398_abnormal_bone_marrow1.03845510
81MP0005397_hematopoietic_system_phenotyp1.03603728
82MP0001545_abnormal_hematopoietic_system1.03603728
83MP0009333_abnormal_splenocyte_physiolog1.02320155
84MP0009763_increased_sensitivity_to1.01159145
85MP0003075_altered_response_to1.00455167
86MP0002396_abnormal_hematopoietic_system0.99820661
87MP0000569_abnormal_digit_pigmentation0.99630565
88MP0005167_abnormal_blood-brain_barrier0.99244943
89MP0000598_abnormal_liver_morphology0.99200923
90MP0005584_abnormal_enzyme/coenzyme_acti0.98831938
91MP0002722_abnormal_immune_system0.97106482
92MP0003186_abnormal_redox_activity0.96008367
93MP0004185_abnormal_adipocyte_glucose0.94833038
94MP0002429_abnormal_blood_cell0.93038550
95MP0005390_skeleton_phenotype0.92469130
96MP0004782_abnormal_surfactant_physiolog0.92136612
97MP0003091_abnormal_cell_migration0.91992056
98MP0005310_abnormal_salivary_gland0.91622921
99MP0004381_abnormal_hair_follicle0.90749979
100MP0004264_abnormal_extraembryonic_tissu0.90495688
101MP0004808_abnormal_hematopoietic_stem0.88526814
102MP0001216_abnormal_epidermal_layer0.87232674
103MP0000858_altered_metastatic_potential0.87077374
104MP0000343_altered_response_to0.86765118
105MP0003195_calcinosis0.86206514
106MP0005075_abnormal_melanosome_morpholog0.85963373
107MP0004510_myositis0.84173018
108MP0005166_decreased_susceptibility_to0.83772407
109MP0000015_abnormal_ear_pigmentation0.82458554
110MP0000604_amyloidosis0.81602458
111MP0000465_gastrointestinal_hemorrhage0.80972262
112MP0003448_altered_tumor_morphology0.80763747
113MP0005670_abnormal_white_adipose0.80662045
114MP0001764_abnormal_homeostasis0.80308271
115MP0003795_abnormal_bone_structure0.79226140
116MP0009765_abnormal_xenobiotic_induced0.79100486
117MP0002928_abnormal_bile_duct0.78993009
118MP0006054_spinal_hemorrhage0.78426889
119MP0003866_abnormal_defecation0.77309167
120MP0001851_eye_inflammation0.76958106
121MP0003183_abnormal_peptide_metabolism0.75551798
122MP0002009_preneoplasia0.75434998
123MP0000249_abnormal_blood_vessel0.73419073
124MP0000490_abnormal_crypts_of0.67860976
125MP0003690_abnormal_glial_cell0.67566017
126MP0005165_increased_susceptibility_to0.67242172
127MP0003221_abnormal_cardiomyocyte_apopto0.63806656
128MP0005076_abnormal_cell_differentiation0.62853196
129MP0002019_abnormal_tumor_incidence0.61123598
130MP0000371_diluted_coat_color0.60969291
131MP0003045_fibrosis0.58386455

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.97868406
2Complement deficiency (HP:0004431)4.59484541
3Optic neuritis (HP:0100653)4.51008130
4Retrobulbar optic neuritis (HP:0100654)4.51008130
5Stomatitis (HP:0010280)4.36956902
6T lymphocytopenia (HP:0005403)4.07898955
7Eczematoid dermatitis (HP:0000976)3.96341419
8Abnormality of T cell number (HP:0011839)3.80662448
9Glomerulonephritis (HP:0000099)3.73988434
10Deep venous thrombosis (HP:0002625)3.73118827
11Recurrent gram-negative bacterial infections (HP:0005420)3.64961009
12Abnormality of complement system (HP:0005339)3.61448570
13Intrahepatic cholestasis (HP:0001406)3.58653603
14Xanthomatosis (HP:0000991)3.58226188
15Mediastinal lymphadenopathy (HP:0100721)3.53934976
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52056193
17Gastrointestinal infarctions (HP:0005244)3.45920293
18Keratoconjunctivitis sicca (HP:0001097)3.40575708
19Recurrent bacterial skin infections (HP:0005406)3.28600448
20Chronic obstructive pulmonary disease (HP:0006510)3.28557053
21Obstructive lung disease (HP:0006536)3.28557053
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.25371745
23Vacuolated lymphocytes (HP:0001922)3.23744569
24Recurrent abscess formation (HP:0002722)3.18658074
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10900430
26Meningitis (HP:0001287)3.10757468
27Keratoconjunctivitis (HP:0001096)3.09020370
28Myocardial infarction (HP:0001658)3.05422852
29Prolonged bleeding time (HP:0003010)3.02900376
30Recurrent cutaneous fungal infections (HP:0011370)3.01202953
31Chronic mucocutaneous candidiasis (HP:0002728)3.01202953
32Pulmonary infiltrates (HP:0002113)2.99455988
33Vasculitis (HP:0002633)2.94170906
34Encephalitis (HP:0002383)2.93576831
35Hemoptysis (HP:0002105)2.88772546
36Nephritis (HP:0000123)2.82313645
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.80323839
38Pustule (HP:0200039)2.79996414
39Hypobetalipoproteinemia (HP:0003563)2.79605278
40Chest pain (HP:0100749)2.77784018
41Interstitial pulmonary disease (HP:0006530)2.77150615
42Hematochezia (HP:0002573)2.72619257
43Joint hemorrhage (HP:0005261)2.72446907
44Abnormality of the common coagulation pathway (HP:0010990)2.71629869
45Abnormality of macrophages (HP:0004311)2.70639786
46Esophageal varix (HP:0002040)2.70510030
47Abnormality of T cells (HP:0002843)2.69741963
48Gangrene (HP:0100758)2.68349823
49Leukocytosis (HP:0001974)2.67664313
50Autoimmune thrombocytopenia (HP:0001973)2.66681002
51Hyperlipoproteinemia (HP:0010980)2.64362043
52Dysostosis multiplex (HP:0000943)2.62803241
53Recurrent fungal infections (HP:0002841)2.60413575
54Petechiae (HP:0000967)2.60212418
55Prolonged partial thromboplastin time (HP:0003645)2.59461097
56Hyperglycinuria (HP:0003108)2.57806376
57Episodic fever (HP:0001954)2.57571575
58Peritonitis (HP:0002586)2.51731473
59Abnormality of purine metabolism (HP:0004352)2.51433336
60Mucopolysacchariduria (HP:0008155)2.49676258
61Urinary glycosaminoglycan excretion (HP:0003541)2.49676258
62Abnormal platelet volume (HP:0011876)2.49641837
63Colitis (HP:0002583)2.49134265
64Elevated erythrocyte sedimentation rate (HP:0003565)2.49033394
65Hyperammonemia (HP:0001987)2.47177407
66Anorexia (HP:0002039)2.46636181
67Abnormality of the nasal mucosa (HP:0000433)2.40369679
68Spontaneous hematomas (HP:0007420)2.40095325
69Hepatosplenomegaly (HP:0001433)2.39690157
70Recurrent skin infections (HP:0001581)2.38923979
71Axonal loss (HP:0003447)2.37390362
72Hypoglycemic coma (HP:0001325)2.37055597
73Increased IgM level (HP:0003496)2.36919563
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.36768488
75Purpura (HP:0000979)2.35908473
76Myositis (HP:0100614)2.33352538
77Abnormality of nucleobase metabolism (HP:0010932)2.32393656
78Recurrent viral infections (HP:0004429)2.31360820
79IgM deficiency (HP:0002850)2.30684373
80Fat malabsorption (HP:0002630)2.30220597
81Polycythemia (HP:0001901)2.29624033
82Nasal polyposis (HP:0100582)2.28799964
83Loss of speech (HP:0002371)2.26759310
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26058779
85Abnormality of polysaccharide metabolism (HP:0011012)2.26058779
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26058779
87Autoimmune hemolytic anemia (HP:0001890)2.25566590
88Increased cerebral lipofuscin (HP:0011813)2.24645256
89Gingival bleeding (HP:0000225)2.24565780
90Hypolipoproteinemia (HP:0010981)2.24431507
91Cellulitis (HP:0100658)2.24358492
92Osteomyelitis (HP:0002754)2.23818241
93Gout (HP:0001997)2.23687041
94Chronic otitis media (HP:0000389)2.23110414
95Cerebral aneurysm (HP:0004944)2.21805951
96Joint swelling (HP:0001386)2.21259120
97Chronic diarrhea (HP:0002028)2.21206791
98Increased IgE level (HP:0003212)2.20208900
99Glomerulopathy (HP:0100820)2.20145127
100Granulocytopenia (HP:0001913)2.19377764
101Ketosis (HP:0001946)2.16953545
102Hydroxyprolinuria (HP:0003080)2.16695427
103Abnormality of proline metabolism (HP:0010907)2.16695427
104Premature loss of primary teeth (HP:0006323)2.16401415
105Inflammation of the large intestine (HP:0002037)2.16328248
106Abnormality of glycolipid metabolism (HP:0010969)2.15915445
107Abnormality of liposaccharide metabolism (HP:0010968)2.15915445
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.15915445
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15582950
110Eosinophilia (HP:0001880)2.15469965
111Abnormality of glycine metabolism (HP:0010895)2.12104352
112Abnormality of serine family amino acid metabolism (HP:0010894)2.12104352
113Abnormality of the intrinsic pathway (HP:0010989)2.11759012
114Abnormality of fatty-acid metabolism (HP:0004359)2.11575005
115Increased mean platelet volume (HP:0011877)2.10458794
116Amaurosis fugax (HP:0100576)2.08709727
117Epidermoid cyst (HP:0200040)2.08427569
118Gastrointestinal inflammation (HP:0004386)2.08027307
119Periodontitis (HP:0000704)2.07919066
120Hypoalphalipoproteinemia (HP:0003233)2.03863303
121Hemorrhage of the eye (HP:0011885)2.03677089
122Increased neuronal autofluorescent lipopigment (HP:0002074)2.01683909
123Abnormality of the pleura (HP:0002103)2.00831342
124Recurrent bronchitis (HP:0002837)2.00547622
125Abnormality of the prostate (HP:0008775)2.00534740
126Hypercholesterolemia (HP:0003124)2.00416686
127Vascular calcification (HP:0004934)1.99818165
128Skin ulcer (HP:0200042)1.99239735
129Abnormal platelet function (HP:0011869)1.98431259
130Impaired platelet aggregation (HP:0003540)1.98431259
131Hypergammaglobulinemia (HP:0010702)1.97766984
132Subacute progressive viral hepatitis (HP:0006572)1.97425002
133Polyneuropathy (HP:0001271)1.97264025
134Abnormality of transition element cation homeostasis (HP:0011030)1.94889729
135Abnormality of pyrimidine metabolism (HP:0004353)1.94314296
136Thrombophlebitis (HP:0004418)1.94104521
137Arterial thrombosis (HP:0004420)1.93724155
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93588921
139Fatigue (HP:0012378)1.93059610
140Amyloidosis (HP:0011034)1.92672612
141Abnormality of the peritoneum (HP:0002585)1.92051175
142Urticaria (HP:0001025)1.91166400
143Gingivitis (HP:0000230)1.90472759
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89077484
145Abnormal enzyme/coenzyme activity (HP:0012379)1.88592345
146Abnormality of iron homeostasis (HP:0011031)1.87805652
147Hyperglycinemia (HP:0002154)1.87631717
148Epistaxis (HP:0000421)1.86770635
149Progressive neurologic deterioration (HP:0002344)1.86718589
150Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86035653
151Abnormality of eosinophils (HP:0001879)1.85760493
152Hepatocellular carcinoma (HP:0001402)1.85410489
153Pulmonary embolism (HP:0002204)1.83689772
154Abnormality of T cell physiology (HP:0011840)1.83631386
155Orchitis (HP:0100796)1.82866659
156Acute hepatic failure (HP:0006554)1.80887409
157Menorrhagia (HP:0000132)1.79625887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.75223130
2ERN13.54943462
3TYK23.05744471
4FGFR42.84413915
5MAP4K12.68591350
6BMPR22.51391234
7TRIB32.44517091
8STK102.23040083
9BLK2.20192650
10TBK12.16860594
11PKN22.16272852
12EPHB12.13221102
13JAK32.08620670
14MAP3K142.06073268
15FES2.00662213
16CSF1R1.86517615
17ZAP701.86110169
18FGR1.83618280
19JAK11.81993381
20SIK11.81789786
21IRAK31.75717560
22PTK61.72998163
23BCKDK1.72690537
24PRPF4B1.70200952
25KDR1.64580318
26EEF2K1.60605768
27MAPK151.60296642
28EPHA31.56489026
29CSK1.52175951
30SIK31.50581362
31LRRK21.49882291
32MAP2K31.47942121
33MAP3K101.43929500
34IKBKE1.40620222
35ITK1.40124722
36MAP3K31.38637942
37IKBKB1.38113213
38MAP3K21.36867564
39FLT31.36527508
40GRK61.34905611
41TAOK31.31678406
42BTK1.30194041
43JAK21.27541122
44IRAK41.27501099
45NEK91.26300680
46FGFR31.22115426
47YES11.18644798
48IRAK21.18583648
49MAP3K131.17601726
50CAMK1D1.16956334
51KIT1.15364237
52TESK21.09420898
53PAK41.07723872
54MAP3K11.07697360
55TXK1.04160353
56MATK0.99722921
57MST1R0.98486880
58TAOK20.98080187
59CHUK0.97024959
60MAP3K120.96596781
61RPS6KA40.95318337
62TEC0.94913753
63STK240.94824197
64EPHA20.94822504
65HCK0.91835456
66RIPK10.89409648
67CDK60.89291082
68MST40.89006867
69PIM10.86614544
70NLK0.85762933
71MAPKAPK30.83512252
72LCK0.83297834
73MAPK110.81399634
74TNK20.81138563
75TGFBR10.79035813
76SYK0.76583161
77KSR20.76400066
78TAOK10.72331940
79MAP2K20.71109687
80TIE10.66069326
81MAP3K50.65058613
82PIK3CG0.64507825
83MAP3K60.64444851
84LYN0.64213575
85STK30.61674876
86NME20.61504037
87RIPK40.61469574
88MAP3K110.57979423
89FRK0.56487219
90PRKAA20.56007451
91CDK40.55759444
92MOS0.55559721
93MAP3K80.55453447
94ERBB30.55049088
95GSK3A0.54393883
96MARK30.54095428
97CDK120.53489042
98MAP3K70.52473059
99RPS6KB20.50209589
100RAF10.49067188
101PTK2B0.47277263
102EGFR0.46934093
103FYN0.46823072
104IRAK10.46800229
105PIM20.46280448
106KSR10.44071325
107FER0.43973099
108PRKCQ0.43724523
109DYRK1B0.43697168
110GRK70.43503987
111IGF1R0.43181069
112MAPKAPK20.42191552
113TRPM70.41895215
114PDPK10.41250364
115STK40.40780555
116PTK20.40635383
117CAMK1G0.37667698
118PDGFRB0.37441006
119ABL10.35832292
120SCYL20.35453456
121PDK10.35191106
122MAPK70.32497446
123MTOR0.31739875
124PRKG20.31563474
125MAPK40.30845901
126CAMKK20.30641259
127MELK0.30569161
128ACVR1B0.29712542
129MAPK120.29174193
130RET0.28896834
131PRKCD0.27284619

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.21101043
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.84669415
3Caffeine metabolism_Homo sapiens_hsa002322.59490327
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.58465571
5Graft-versus-host disease_Homo sapiens_hsa053322.54243977
6Autoimmune thyroid disease_Homo sapiens_hsa053202.39923782
7Nitrogen metabolism_Homo sapiens_hsa009102.39754833
8Complement and coagulation cascades_Homo sapiens_hsa046102.36484725
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21195287
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03976249
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00440634
12Fatty acid degradation_Homo sapiens_hsa000711.94070609
13Arginine biosynthesis_Homo sapiens_hsa002201.92480577
14Asthma_Homo sapiens_hsa053101.91970990
15Type I diabetes mellitus_Homo sapiens_hsa049401.89670329
16Tryptophan metabolism_Homo sapiens_hsa003801.85672544
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69672836
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63748389
19Other glycan degradation_Homo sapiens_hsa005111.58123740
20Rheumatoid arthritis_Homo sapiens_hsa053231.57390635
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.54334824
22PPAR signaling pathway_Homo sapiens_hsa033201.50939928
23Viral myocarditis_Homo sapiens_hsa054161.49471419
24Phagosome_Homo sapiens_hsa041451.48255497
25Leishmaniasis_Homo sapiens_hsa051401.47836595
26Peroxisome_Homo sapiens_hsa041461.47054882
27Chemokine signaling pathway_Homo sapiens_hsa040621.46817569
28Histidine metabolism_Homo sapiens_hsa003401.42829984
29Osteoclast differentiation_Homo sapiens_hsa043801.32658854
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28331190
31ABC transporters_Homo sapiens_hsa020101.28172673
32Fatty acid metabolism_Homo sapiens_hsa012121.27650510
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.26562547
34Selenocompound metabolism_Homo sapiens_hsa004501.26242477
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25559586
36Salmonella infection_Homo sapiens_hsa051321.25084079
37Antigen processing and presentation_Homo sapiens_hsa046121.23371430
38beta-Alanine metabolism_Homo sapiens_hsa004101.21893887
39Lysosome_Homo sapiens_hsa041421.20179269
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19275339
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.19119552
42Platelet activation_Homo sapiens_hsa046111.18524516
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17729560
44Propanoate metabolism_Homo sapiens_hsa006401.13713695
45Folate biosynthesis_Homo sapiens_hsa007901.13598866
46Legionellosis_Homo sapiens_hsa051341.12767722
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12204935
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.11089469
49Chemical carcinogenesis_Homo sapiens_hsa052041.10340582
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08501069
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08313069
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07722054
53Primary immunodeficiency_Homo sapiens_hsa053401.06638855
54African trypanosomiasis_Homo sapiens_hsa051431.04753078
55Pertussis_Homo sapiens_hsa051331.04552786
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04266801
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04038605
58Measles_Homo sapiens_hsa051621.02575711
59Toxoplasmosis_Homo sapiens_hsa051451.01799031
60B cell receptor signaling pathway_Homo sapiens_hsa046621.01297857
61Vitamin digestion and absorption_Homo sapiens_hsa049771.01275295
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.01122627
63Non-small cell lung cancer_Homo sapiens_hsa052230.99570513
64Retinol metabolism_Homo sapiens_hsa008300.98657529
65Fat digestion and absorption_Homo sapiens_hsa049750.98037110
66Bile secretion_Homo sapiens_hsa049760.92556138
67Sulfur relay system_Homo sapiens_hsa041220.92304176
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91687705
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90035326
70Phenylalanine metabolism_Homo sapiens_hsa003600.89677009
71Starch and sucrose metabolism_Homo sapiens_hsa005000.87898995
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87652192
73Pentose phosphate pathway_Homo sapiens_hsa000300.87057423
74Fatty acid biosynthesis_Homo sapiens_hsa000610.85513427
75Butanoate metabolism_Homo sapiens_hsa006500.84009569
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81713923
77Amoebiasis_Homo sapiens_hsa051460.79446303
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.77991993
79Influenza A_Homo sapiens_hsa051640.77861108
80Sulfur metabolism_Homo sapiens_hsa009200.77333124
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.77208070
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77121618
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.77118718
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75093594
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72870347
86Prolactin signaling pathway_Homo sapiens_hsa049170.72327104
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71133197
88Tuberculosis_Homo sapiens_hsa051520.70966234
89Hematopoietic cell lineage_Homo sapiens_hsa046400.70804232
90Insulin resistance_Homo sapiens_hsa049310.70694724
91Epstein-Barr virus infection_Homo sapiens_hsa051690.70479626
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.70082518
93TNF signaling pathway_Homo sapiens_hsa046680.68752653
94Lysine degradation_Homo sapiens_hsa003100.67286309
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.65774891
96Pyruvate metabolism_Homo sapiens_hsa006200.65588501
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65387898
98Carbon metabolism_Homo sapiens_hsa012000.65258484
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64791904
100Acute myeloid leukemia_Homo sapiens_hsa052210.64749900
101Herpes simplex infection_Homo sapiens_hsa051680.64158164
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.64051377
103Hepatitis C_Homo sapiens_hsa051600.64049908
104Renal cell carcinoma_Homo sapiens_hsa052110.63692678
105Endocytosis_Homo sapiens_hsa041440.63539119
106Viral carcinogenesis_Homo sapiens_hsa052030.62668643
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62017300
108Apoptosis_Homo sapiens_hsa042100.61495614
109Prion diseases_Homo sapiens_hsa050200.59964743
110Thyroid cancer_Homo sapiens_hsa052160.59302394
111Glycerolipid metabolism_Homo sapiens_hsa005610.58779519
112Biosynthesis of amino acids_Homo sapiens_hsa012300.58413744
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57939913
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57529850
115Glutathione metabolism_Homo sapiens_hsa004800.55579666
116Malaria_Homo sapiens_hsa051440.55225147
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54085987
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51639033
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.51396602
120Tyrosine metabolism_Homo sapiens_hsa003500.50369662
121Galactose metabolism_Homo sapiens_hsa000520.49943253
122Small cell lung cancer_Homo sapiens_hsa052220.49787476
123Pancreatic cancer_Homo sapiens_hsa052120.49599698
124T cell receptor signaling pathway_Homo sapiens_hsa046600.49121244
125Bladder cancer_Homo sapiens_hsa052190.48412469
126Prostate cancer_Homo sapiens_hsa052150.47285622
127VEGF signaling pathway_Homo sapiens_hsa043700.46997419
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46455282
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45741392
130HTLV-I infection_Homo sapiens_hsa051660.45692970
131Arginine and proline metabolism_Homo sapiens_hsa003300.45551659
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44908603
133Shigellosis_Homo sapiens_hsa051310.44831424
134Allograft rejection_Homo sapiens_hsa053300.44828829
135Hepatitis B_Homo sapiens_hsa051610.44756410
136Chronic myeloid leukemia_Homo sapiens_hsa052200.44183101
137FoxO signaling pathway_Homo sapiens_hsa040680.42434759
138Endometrial cancer_Homo sapiens_hsa052130.40776822
139Sphingolipid metabolism_Homo sapiens_hsa006000.38666919
140Proteoglycans in cancer_Homo sapiens_hsa052050.36589569
141HIF-1 signaling pathway_Homo sapiens_hsa040660.36581522
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32662837
143Dorso-ventral axis formation_Homo sapiens_hsa043200.29918640
144Colorectal cancer_Homo sapiens_hsa052100.28582497
145p53 signaling pathway_Homo sapiens_hsa041150.24788564
146Inositol phosphate metabolism_Homo sapiens_hsa005620.22589377
147Arachidonic acid metabolism_Homo sapiens_hsa005900.22479425
148mTOR signaling pathway_Homo sapiens_hsa041500.21391001
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.20108359

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