CMTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.34157802
2protein localization to kinetochore (GO:0034501)5.14100505
3response to pheromone (GO:0019236)5.05985947
4DNA unwinding involved in DNA replication (GO:0006268)4.84879680
5mitotic chromosome condensation (GO:0007076)4.61972040
6DNA strand elongation involved in DNA replication (GO:0006271)4.31992752
7protein localization to chromosome, centromeric region (GO:0071459)4.26694948
8DNA strand elongation (GO:0022616)4.12924797
9mitotic nuclear envelope disassembly (GO:0007077)4.12226361
10DNA replication initiation (GO:0006270)4.08887867
11establishment of protein localization to Golgi (GO:0072600)3.94922476
12histone H2A monoubiquitination (GO:0035518)3.94500174
13telomere maintenance via semi-conservative replication (GO:0032201)3.91922355
14protein targeting to Golgi (GO:0000042)3.89623560
15DNA replication-dependent nucleosome organization (GO:0034723)3.87979475
16DNA replication-dependent nucleosome assembly (GO:0006335)3.87979475
17membrane disassembly (GO:0030397)3.85043222
18nuclear envelope disassembly (GO:0051081)3.85043222
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.71681128
20IMP metabolic process (GO:0046040)3.68179690
21mitotic recombination (GO:0006312)3.60422294
22dosage compensation (GO:0007549)3.60331559
23retrograde transport, vesicle recycling within Golgi (GO:0000301)3.59735876
24telomere maintenance via recombination (GO:0000722)3.57461985
25nuclear pore complex assembly (GO:0051292)3.56082786
26positive regulation of granulocyte differentiation (GO:0030854)3.55987697
27COPII vesicle coating (GO:0048208)3.55235127
28mitotic metaphase plate congression (GO:0007080)3.51113589
29protein localization to chromosome (GO:0034502)3.47393612
30pteridine-containing compound biosynthetic process (GO:0042559)3.46651311
31negative regulation of histone methylation (GO:0031061)3.41978196
32Golgi transport vesicle coating (GO:0048200)3.40216183
33COPI coating of Golgi vesicle (GO:0048205)3.40216183
34prostate gland growth (GO:0060736)3.37289922
35definitive hemopoiesis (GO:0060216)3.34775833
36IMP biosynthetic process (GO:0006188)3.33937756
37DNA double-strand break processing (GO:0000729)3.32985727
38DNA replication-independent nucleosome organization (GO:0034724)3.29893127
39DNA replication-independent nucleosome assembly (GO:0006336)3.29893127
40regulation of centriole replication (GO:0046599)3.28401651
41attachment of spindle microtubules to kinetochore (GO:0008608)3.28085802
42nuclear pore organization (GO:0006999)3.26911124
43intestinal epithelial cell development (GO:0060576)3.26633936
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.25131766
45genitalia morphogenesis (GO:0035112)3.24001943
46resolution of meiotic recombination intermediates (GO:0000712)3.22312924
47CENP-A containing nucleosome assembly (GO:0034080)3.21626102
48ribosomal small subunit assembly (GO:0000028)3.20959779
49hepatocyte apoptotic process (GO:0097284)3.16017195
50nucleobase biosynthetic process (GO:0046112)3.15782250
51chromatin remodeling at centromere (GO:0031055)3.14309868
52histone H2A ubiquitination (GO:0033522)3.13766818
53chromatin assembly or disassembly (GO:0006333)3.12983435
54mitochondrial DNA replication (GO:0006264)3.12351880
55nuclear envelope organization (GO:0006998)3.11151678
56formation of translation preinitiation complex (GO:0001731)3.10225880
57nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.10022065
58sister chromatid segregation (GO:0000819)3.05145139
59metaphase plate congression (GO:0051310)3.05111376
60protein targeting to vacuole (GO:0006623)3.02364605
61protein targeting to lysosome (GO:0006622)3.02364605
62establishment of protein localization to vacuole (GO:0072666)3.02364605
63translesion synthesis (GO:0019985)3.00561309
64Rap protein signal transduction (GO:0032486)3.00193940
65telomere maintenance via telomere lengthening (GO:0010833)2.98915921
66establishment of chromosome localization (GO:0051303)2.98248438
67maturation of 5.8S rRNA (GO:0000460)2.95805858
68interkinetic nuclear migration (GO:0022027)2.93254680
69intra-Golgi vesicle-mediated transport (GO:0006891)2.92479633
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.91685258
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91685258
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91685258
73viral transcription (GO:0019083)2.91286498
74mitotic sister chromatid segregation (GO:0000070)2.91123258
75DNA replication checkpoint (GO:0000076)2.90055287
76DNA duplex unwinding (GO:0032508)2.88198099
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88101721
78regulation of sister chromatid cohesion (GO:0007063)2.86986914
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86167785
80DNA geometric change (GO:0032392)2.85727892
81ribosome assembly (GO:0042255)2.83749049
82neural tube formation (GO:0001841)2.83431159
83ncRNA 3-end processing (GO:0043628)2.83405881
84translational termination (GO:0006415)2.83371531
85mitotic sister chromatid cohesion (GO:0007064)2.83138424
86sister chromatid cohesion (GO:0007062)2.82951575
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82303502
88isotype switching (GO:0045190)2.82303502
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82303502
90regulation of B cell receptor signaling pathway (GO:0050855)2.80999803
91translational initiation (GO:0006413)2.80558076
92histone mRNA catabolic process (GO:0071044)2.79845470
93rRNA methylation (GO:0031167)2.79210191
94cotranslational protein targeting to membrane (GO:0006613)2.78872614
95protein targeting to ER (GO:0045047)2.78806654
963-UTR-mediated mRNA stabilization (GO:0070935)2.78643035
97protein prenylation (GO:0018342)2.78607472
98prenylation (GO:0097354)2.78607472
99negative regulation of RNA splicing (GO:0033119)2.78323161
100regulation of establishment of cell polarity (GO:2000114)2.77177144
101regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76315772
102positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76315772
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75844799
104UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74682659
105regulation of transforming growth factor beta2 production (GO:0032909)2.73879151
106positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.71687949
107regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.71687949
108regulation of Rac protein signal transduction (GO:0035020)2.71314974
109replication fork processing (GO:0031297)2.71033000
110positive regulation of chromosome segregation (GO:0051984)2.70800279
111positive regulation of developmental pigmentation (GO:0048087)2.70779585
112translational elongation (GO:0006414)2.70604873
113kinetochore organization (GO:0051383)2.70036174
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68517336
115regulation of spindle organization (GO:0090224)2.68492131
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.68432865
117early endosome to late endosome transport (GO:0045022)2.66568727
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65604116
119Golgi to endosome transport (GO:0006895)2.65400124
120chromosome segregation (GO:0007059)2.64728199
121base-excision repair (GO:0006284)2.64114276
122positive regulation of histone H3-K4 methylation (GO:0051571)2.63788499
123keratinocyte development (GO:0003334)2.63181951
124regulation of histone H3-K9 methylation (GO:0051570)2.62899412
125protein localization to endoplasmic reticulum (GO:0070972)2.62741461
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62294042
127protein localization to Golgi apparatus (GO:0034067)2.62215316
128double-strand break repair via nonhomologous end joining (GO:0006303)2.61376211
129non-recombinational repair (GO:0000726)2.61376211
130response to UV-C (GO:0010225)2.59527480
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58848539
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.58848539
133mRNA stabilization (GO:0048255)2.58386218
134RNA stabilization (GO:0043489)2.58386218
135positive regulation of DNA-templated transcription, initiation (GO:2000144)2.58021104
136regulation of histone H3-K27 methylation (GO:0061085)2.57772664
137nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.57184415
138chromatin assembly (GO:0031497)2.56660813
139histone exchange (GO:0043486)2.56290997
140negative regulation of mRNA processing (GO:0050686)2.56188685
141histone mRNA metabolic process (GO:0008334)2.56064222
142oocyte development (GO:0048599)2.56005040
143base-excision repair, AP site formation (GO:0006285)2.55706486
144chromosome condensation (GO:0030261)2.55673488
145fibroblast migration (GO:0010761)2.54760652
146pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.54430658
147nuclear-transcribed mRNA catabolic process (GO:0000956)2.54128380
148negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52614653
149inositol metabolic process (GO:0006020)2.51532041
150pore complex assembly (GO:0046931)2.50398798
151postreplication repair (GO:0006301)2.49815067
152chaperone mediated protein folding requiring cofactor (GO:0051085)2.49736235
153telomere organization (GO:0032200)2.48178612
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.48062523
155negative regulation of neurotransmitter secretion (GO:0046929)2.47026154
156establishment of integrated proviral latency (GO:0075713)2.46637873
157tetrahydrofolate metabolic process (GO:0046653)2.46185814
158spliceosomal tri-snRNP complex assembly (GO:0000244)2.45742079
159rRNA transcription (GO:0009303)2.45464526
160mRNA catabolic process (GO:0006402)2.45091528
161S-adenosylmethionine metabolic process (GO:0046500)2.42728060
162* mRNA modification (GO:0016556)2.42604022
163protein K11-linked deubiquitination (GO:0035871)2.39994121
164Leydig cell differentiation (GO:0033327)2.39271847
165signal peptide processing (GO:0006465)2.37560819
166regulation of male gonad development (GO:2000018)2.36481007
167endosome to melanosome transport (GO:0035646)2.36067635
168endosome to pigment granule transport (GO:0043485)2.36067635
169embryonic process involved in female pregnancy (GO:0060136)2.35370958
170positive regulation of mRNA 3-end processing (GO:0031442)2.35238889
171positive regulation of mRNA catabolic process (GO:0061014)2.33723819
172cellular response to ethanol (GO:0071361)2.33339523
173peptidyl-lysine trimethylation (GO:0018023)2.32555265
174response to X-ray (GO:0010165)2.29495265
175monoubiquitinated protein deubiquitination (GO:0035520)2.28726282
176regulation of granulocyte differentiation (GO:0030852)2.27983240
177regulation of establishment or maintenance of cell polarity (GO:0032878)2.27591388
178lymphoid progenitor cell differentiation (GO:0002320)2.26717782
179platelet dense granule organization (GO:0060155)2.24829355
180positive regulation of glycoprotein biosynthetic process (GO:0010560)2.23198596
181DNA integration (GO:0015074)2.22654499
182regulation of pigment cell differentiation (GO:0050932)2.21380321
183regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.20770198
184cellular response to arsenic-containing substance (GO:0071243)2.20493216
185photoreceptor cell maintenance (GO:0045494)2.18965679
186somatic recombination of immunoglobulin gene segments (GO:0016447)2.18640929
187positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.17754757
188short-chain fatty acid metabolic process (GO:0046459)2.17631321
189ether lipid metabolic process (GO:0046485)2.15613648
190phosphorylated carbohydrate dephosphorylation (GO:0046838)2.13472201
191inositol phosphate dephosphorylation (GO:0046855)2.13472201
192double-strand break repair via homologous recombination (GO:0000724)2.13439573
193lung lobe morphogenesis (GO:0060463)2.13268056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.78158364
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.79528094
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.66091236
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36446488
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20285939
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15439975
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04002258
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.95101135
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89370532
10MYC_22102868_ChIP-Seq_BL_Human2.84384853
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.81047073
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75243535
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59146863
14FUS_26573619_Chip-Seq_HEK293_Human2.42734262
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34027679
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28275960
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.25796170
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22655984
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22301379
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.17407172
21ZNF274_21170338_ChIP-Seq_K562_Hela2.16025495
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.13796231
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13634790
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10112290
25XRN2_22483619_ChIP-Seq_HELA_Human2.08628689
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06608237
27VDR_23849224_ChIP-Seq_CD4+_Human2.05100749
28AR_21909140_ChIP-Seq_LNCAP_Human2.02487009
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02005972
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.01418275
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.96950493
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96233698
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.93834841
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92181732
35TAF15_26573619_Chip-Seq_HEK293_Human1.90901597
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89371934
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84057932
38FOXP3_21729870_ChIP-Seq_TREG_Human1.82681562
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81149763
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79830697
41EWS_26573619_Chip-Seq_HEK293_Human1.77745337
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75367133
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75312958
44ER_23166858_ChIP-Seq_MCF-7_Human1.74272122
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73788066
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73723181
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73376946
48DCP1A_22483619_ChIP-Seq_HELA_Human1.72896169
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.72066028
50VDR_21846776_ChIP-Seq_THP-1_Human1.70514606
51IGF1R_20145208_ChIP-Seq_DFB_Human1.70032547
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69931986
53GABP_19822575_ChIP-Seq_HepG2_Human1.68907516
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68636112
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68149070
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67070521
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66934552
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65902422
59TTF2_22483619_ChIP-Seq_HELA_Human1.64627479
60CIITA_25753668_ChIP-Seq_RAJI_Human1.63377008
61P300_19829295_ChIP-Seq_ESCs_Human1.61309039
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60901056
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59903525
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58402219
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58316802
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.56019063
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55166100
68IRF1_19129219_ChIP-ChIP_H3396_Human1.54984974
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.53191589
70KDM5A_27292631_Chip-Seq_BREAST_Human1.51272820
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50760029
72ELK1_19687146_ChIP-ChIP_HELA_Human1.50115375
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47981707
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47055296
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46301460
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45628762
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43359112
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40694757
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.40372636
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39404071
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39384375
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39326124
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38923167
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37972437
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37749131
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37743074
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36993326
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36596331
89CDX2_22108803_ChIP-Seq_LS180_Human1.36546960
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33611750
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32808585
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32609857
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32407511
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32378667
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31109573
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30610969
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29444979
98CBP_20019798_ChIP-Seq_JUKART_Human1.29444979
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29267827
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29255143
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28862205
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.28602637
103TFEB_21752829_ChIP-Seq_HELA_Human1.27941875
104AHR_22903824_ChIP-Seq_MCF-7_Human1.27741622
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27173094
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.26819400
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26373450
108BRD4_25478319_ChIP-Seq_HGPS_Human1.25574288
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.24523769
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24222226
111MYB_26560356_Chip-Seq_TH2_Human1.23737228
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23557000
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22578157
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.22160753
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22101233
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21978735
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20760288
118SPI1_23547873_ChIP-Seq_NB4_Human1.20299872
119GATA1_22025678_ChIP-Seq_K562_Human1.20004377
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19502771
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18930081
122WT1_19549856_ChIP-ChIP_CCG9911_Human1.18694451
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18075832
124STAT3_23295773_ChIP-Seq_U87_Human1.17813558
125NOTCH1_21737748_ChIP-Seq_TLL_Human1.17447177
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17429894
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16963476
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16963476
129SMAD4_21799915_ChIP-Seq_A2780_Human1.16367222
130UTX_26944678_Chip-Seq_JUKART_Human1.15733152
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15052692
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13531157
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13206689
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13016165
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12963185
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12506936
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11512216
138SALL4_22934838_ChIP-ChIP_CD34+_Human1.11097686
139GBX2_23144817_ChIP-Seq_PC3_Human1.10310962
140RUNX1_22412390_ChIP-Seq_EML_Mouse1.10275644
141E2F1_18555785_Chip-Seq_ESCs_Mouse1.08625536
142STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08459839
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06059337
144SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05500622
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05032968
146TP53_18474530_ChIP-ChIP_U2OS_Human1.04547116
147TCF7_22412390_ChIP-Seq_EML_Mouse1.04407213
148PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03892027
149SALL1_21062744_ChIP-ChIP_HESCs_Human1.03681716
150FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03628292
151BCAT_22108803_ChIP-Seq_LS180_Human1.03364046
152P53_22387025_ChIP-Seq_ESCs_Mouse1.03303166
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02942965
154IRF8_21731497_ChIP-ChIP_J774_Mouse1.02908110
155PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02891137
156SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02721853
157MYB_26560356_Chip-Seq_TH1_Human1.02502638
158CJUN_26792858_Chip-Seq_BT549_Human1.00111392
159MAF_26560356_Chip-Seq_TH1_Human0.99373875
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98965500
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.98878458
162GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98852526
163TP63_23658742_ChIP-Seq_EP156T_Human0.98658897
164VDR_24763502_ChIP-Seq_THP-1_Human0.98464343
165SMAD3_21741376_ChIP-Seq_EPCs_Human0.98183770
166OCT4_18555785_Chip-Seq_ESCs_Mouse0.97971822
167P300_18555785_Chip-Seq_ESCs_Mouse0.97765241
168BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97452440
169TCF4_18268006_ChIP-ChIP_LS174T_Human0.97106339
170SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96539889
171CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96131670
172IRF8_27001747_Chip-Seq_BMDM_Mouse0.95748145
173SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95712421
174RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94527619
175SRF_21415370_ChIP-Seq_HL-1_Mouse0.93990832
176MYC_18940864_ChIP-ChIP_HL60_Human0.93901076
177NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93542560
178NANOG_21062744_ChIP-ChIP_HESCs_Human0.91183906
179CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90826146
180SCL_19346495_ChIP-Seq_HPC-7_Human0.89355558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.94777059
2MP0010234_abnormal_vibrissa_follicle3.78531129
3MP0010094_abnormal_chromosome_stability3.66274911
4MP0004957_abnormal_blastocyst_morpholog3.17257354
5MP0010678_abnormal_skin_adnexa3.15369567
6MP0003077_abnormal_cell_cycle3.09483924
7MP0003111_abnormal_nucleus_morphology2.97890908
8MP0002877_abnormal_melanocyte_morpholog2.94903436
9MP0000383_abnormal_hair_follicle2.79678249
10MP0009697_abnormal_copulation2.76696464
11MP0002396_abnormal_hematopoietic_system2.70657831
12MP0008057_abnormal_DNA_replication2.62281999
13MP0003763_abnormal_thymus_physiology2.45395367
14MP0008007_abnormal_cellular_replicative2.40357152
15MP0000427_abnormal_hair_cycle2.22363223
16MP0000372_irregular_coat_pigmentation2.21681543
17MP0008058_abnormal_DNA_repair2.07927473
18MP0000350_abnormal_cell_proliferation2.07509485
19MP0001730_embryonic_growth_arrest2.03589326
20MP0003123_paternal_imprinting2.01839893
21MP0008932_abnormal_embryonic_tissue1.97485629
22MP0006054_spinal_hemorrhage1.93348233
23MP0009333_abnormal_splenocyte_physiolog1.87641858
24MP0000371_diluted_coat_color1.87552361
25MP0000490_abnormal_crypts_of1.86389451
26MP0005248_abnormal_Harderian_gland1.83759656
27MP0002009_preneoplasia1.78673080
28MP0000516_abnormal_urinary_system1.75213801
29MP0005367_renal/urinary_system_phenotyp1.75213801
30MP0003718_maternal_effect1.74455576
31MP0004808_abnormal_hematopoietic_stem1.70060692
32MP0010307_abnormal_tumor_latency1.68268614
33MP0000465_gastrointestinal_hemorrhage1.67101844
34MP0009780_abnormal_chondrocyte_physiolo1.67028804
35MP0002019_abnormal_tumor_incidence1.62774017
36MP0010352_gastrointestinal_tract_polyps1.62552175
37MP0003221_abnormal_cardiomyocyte_apopto1.59009301
38MP0002398_abnormal_bone_marrow1.58947857
39MP0003943_abnormal_hepatobiliary_system1.57418220
40MP0003890_abnormal_embryonic-extraembry1.53554705
41MP0003300_gastrointestinal_ulcer1.51551796
42MP0003436_decreased_susceptibility_to1.50088722
43MP0005076_abnormal_cell_differentiation1.44940880
44MP0000703_abnormal_thymus_morphology1.44793658
45MP0001697_abnormal_embryo_size1.42326499
46MP0000685_abnormal_immune_system1.41402554
47MP0001915_intracranial_hemorrhage1.39106634
48MP0001835_abnormal_antigen_presentation1.37798108
49MP0001529_abnormal_vocalization1.34893710
50MP0001800_abnormal_humoral_immune1.34525193
51MP0000689_abnormal_spleen_morphology1.32749907
52MP0001545_abnormal_hematopoietic_system1.32654455
53MP0005397_hematopoietic_system_phenotyp1.32654455
54MP0003172_abnormal_lysosome_physiology1.31072595
55MP0002095_abnormal_skin_pigmentation1.29993169
56MP0000313_abnormal_cell_death1.29741192
57MP0002080_prenatal_lethality1.28410634
58MP0008877_abnormal_DNA_methylation1.28369225
59MP0005310_abnormal_salivary_gland1.27006989
60MP0005174_abnormal_tail_pigmentation1.25368923
61MP0000858_altered_metastatic_potential1.22722289
62MP0003121_genomic_imprinting1.22622847
63MP0002722_abnormal_immune_system1.22298946
64MP0001666_abnormal_nutrient_absorption1.21127747
65MP0001672_abnormal_embryogenesis/_devel1.20159122
66MP0005380_embryogenesis_phenotype1.20159122
67MP0001348_abnormal_lacrimal_gland1.18825306
68MP0006072_abnormal_retinal_apoptosis1.18815985
69MP0002085_abnormal_embryonic_tissue1.17961477
70MP0003252_abnormal_bile_duct1.17312054
71MP0002429_abnormal_blood_cell1.17218252
72MP0000716_abnormal_immune_system1.15632095
73MP0009840_abnormal_foam_cell1.14126227
74MP0002084_abnormal_developmental_patter1.11519077
75MP0002086_abnormal_extraembryonic_tissu1.10024516
76MP0000569_abnormal_digit_pigmentation1.09597631
77MP0003984_embryonic_growth_retardation1.08892569
78MP0002420_abnormal_adaptive_immunity1.08635925
79MP0004381_abnormal_hair_follicle1.08455864
80MP0002452_abnormal_antigen_presenting1.07679575
81MP0002088_abnormal_embryonic_growth/wei1.07549792
82MP0003091_abnormal_cell_migration1.07167536
83MP0005085_abnormal_gallbladder_physiolo1.06141981
84MP0005379_endocrine/exocrine_gland_phen1.05390539
85MP0001849_ear_inflammation1.05244791
86MP0002938_white_spotting1.04827238
87MP0001819_abnormal_immune_cell1.04639427
88MP0004197_abnormal_fetal_growth/weight/1.03776164
89MP0000377_abnormal_hair_follicle1.03124067
90MP0002254_reproductive_system_inflammat1.02988387
91MP0002933_joint_inflammation1.02794130
92MP0005671_abnormal_response_to1.02309759
93MP0005408_hypopigmentation1.01800486
94MP0005000_abnormal_immune_tolerance1.01383714
95MP0002405_respiratory_system_inflammati1.01122616
96MP0001119_abnormal_female_reproductive1.00554594
97MP0002098_abnormal_vibrissa_morphology0.99573255
98MP0005220_abnormal_exocrine_pancreas0.99445114
99MP0000358_abnormal_cell_content/0.99421977
100MP0009785_altered_susceptibility_to0.98364203
101MP0002876_abnormal_thyroid_physiology0.97682411
102MP0002723_abnormal_immune_serum0.97278131
103MP0003183_abnormal_peptide_metabolism0.96770351
104MP0004134_abnormal_chest_morphology0.96725611
105MP0005253_abnormal_eye_physiology0.96166434
106MP0002177_abnormal_outer_ear0.94742399
107MP0009115_abnormal_fat_cell0.94735466
108MP0005075_abnormal_melanosome_morpholog0.94731368
109MP0003699_abnormal_female_reproductive0.94395941
110MP0001324_abnormal_eye_pigmentation0.92915202
111MP0000613_abnormal_salivary_gland0.92382562
112MP0001764_abnormal_homeostasis0.92161198
113MP0001790_abnormal_immune_system0.91727487
114MP0005387_immune_system_phenotype0.91727487
115MP0000015_abnormal_ear_pigmentation0.91666082
116MP0001944_abnormal_pancreas_morphology0.91282521
117MP0005023_abnormal_wound_healing0.91137585
118MP0002653_abnormal_ependyma_morphology0.90937681
119MP0004147_increased_porphyrin_level0.90743829
120MP0008789_abnormal_olfactory_epithelium0.90054985
121MP0005384_cellular_phenotype0.88997846
122MP0001873_stomach_inflammation0.88070105
123MP0000462_abnormal_digestive_system0.87914385
124MP0002139_abnormal_hepatobiliary_system0.87238658
125MP0001727_abnormal_embryo_implantation0.86072970
126MP0005621_abnormal_cell_physiology0.86028756
127MP0002693_abnormal_pancreas_physiology0.85978785
128MP0004264_abnormal_extraembryonic_tissu0.85711164
129MP0001191_abnormal_skin_condition0.85416334
130MP0009384_cardiac_valve_regurgitation0.83833870
131MP0005464_abnormal_platelet_physiology0.83478192
132MP0002166_altered_tumor_susceptibility0.83154108
133MP0003656_abnormal_erythrocyte_physiolo0.82810879
134MP0002089_abnormal_postnatal_growth/wei0.82751299
135MP0003868_abnormal_feces_composition0.82119344
136MP0000013_abnormal_adipose_tissue0.80665955
137MP0006082_CNS_inflammation0.79379325
138MP0005275_abnormal_skin_tensile0.79104777
139MP0001216_abnormal_epidermal_layer0.79081446
140MP0000538_abnormal_urinary_bladder0.79030924
141MP0002075_abnormal_coat/hair_pigmentati0.77254899
142MP0003303_peritoneal_inflammation0.76869003
143MP0002006_tumorigenesis0.75755923
144MP0010155_abnormal_intestine_physiology0.75232746
145MP0003567_abnormal_fetal_cardiomyocyte0.74494836
146MP0001186_pigmentation_phenotype0.72335153
147MP0000653_abnormal_sex_gland0.71647358
148MP0000627_abnormal_mammary_gland0.70877411
149MP0001929_abnormal_gametogenesis0.70141535
150MP0005197_abnormal_uvea_morphology0.69431014
151MP0000609_abnormal_liver_physiology0.66090929
152MP0002282_abnormal_trachea_morphology0.65420627
153MP0005084_abnormal_gallbladder_morpholo0.64414259
154MP0003936_abnormal_reproductive_system0.64067111
155MP0003806_abnormal_nucleotide_metabolis0.63287603

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)3.99423673
2Papillary thyroid carcinoma (HP:0002895)3.82051084
3Birth length less than 3rd percentile (HP:0003561)3.80915933
4Thyroid carcinoma (HP:0002890)3.36230138
511 pairs of ribs (HP:0000878)3.26318679
6Aplastic anemia (HP:0001915)3.22276661
7Thyroiditis (HP:0100646)3.06116144
8Metaphyseal cupping (HP:0003021)3.04907137
9Increased density of long bones (HP:0006392)3.00160680
10Cutaneous melanoma (HP:0012056)2.95501263
11Cortical dysplasia (HP:0002539)2.95388200
12Insidious onset (HP:0003587)2.93164457
13Termporal pattern (HP:0011008)2.93164457
14Tubulointerstitial nephritis (HP:0001970)2.88436596
15Hyperacusis (HP:0010780)2.80472424
16Pancreatic islet-cell hyperplasia (HP:0004510)2.77846488
17Curly hair (HP:0002212)2.75720906
18Hematochezia (HP:0002573)2.69038259
19Abnormal number of erythroid precursors (HP:0012131)2.66163290
20Spinal cord lesions (HP:0100561)2.64313483
21Syringomyelia (HP:0003396)2.64313483
22Abnormality of cells of the erythroid lineage (HP:0012130)2.57341291
23Patellar aplasia (HP:0006443)2.54820763
24Nephronophthisis (HP:0000090)2.54583381
25Breast hypoplasia (HP:0003187)2.54221380
26Albinism (HP:0001022)2.51432063
27Abnormality of endocrine pancreas physiology (HP:0012093)2.45421667
28Abnormality of the pancreatic islet cells (HP:0006476)2.45421667
29Short 4th metacarpal (HP:0010044)2.42347019
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42347019
31Papilledema (HP:0001085)2.42128251
32Facial hemangioma (HP:0000329)2.40992908
33Myelodysplasia (HP:0002863)2.37632993
34Abnormality of the calcaneus (HP:0008364)2.37102839
35Renal cortical cysts (HP:0000803)2.36921903
36Abnormality of chromosome stability (HP:0003220)2.36403346
37Entropion (HP:0000621)2.34756131
38Overriding aorta (HP:0002623)2.33476549
39B lymphocytopenia (HP:0010976)2.30186101
40Colon cancer (HP:0003003)2.30115204
41Neoplasm of the adrenal cortex (HP:0100641)2.30015324
42Reticulocytopenia (HP:0001896)2.28841840
43Aplasia/Hypoplasia of the patella (HP:0006498)2.28269316
44Proximal tubulopathy (HP:0000114)2.23844510
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22798080
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.22798080
47Pancreatic cysts (HP:0001737)2.18911344
48Increased nuchal translucency (HP:0010880)2.18690478
49Medial flaring of the eyebrow (HP:0010747)2.18200553
50Tubular atrophy (HP:0000092)2.18061551
51Missing ribs (HP:0000921)2.18011611
52Volvulus (HP:0002580)2.16394007
53Cone-rod dystrophy (HP:0000548)2.15999398
54Elfin facies (HP:0004428)2.15473017
55Abnormality of B cell number (HP:0010975)2.15470549
56Abnormality of the renal cortex (HP:0011035)2.14978786
57Amaurosis fugax (HP:0100576)2.14459348
58Freckling (HP:0001480)2.14326171
59Abnormal biliary tract morphology (HP:0012440)2.13611647
60Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.13353407
61Slender long bone (HP:0003100)2.13125473
62Breast carcinoma (HP:0003002)2.13050640
63Deviation of the thumb (HP:0009603)2.11106718
64Gonadotropin excess (HP:0000837)2.10110735
65Severe short stature (HP:0003510)2.10038010
66Abnormality of the renal medulla (HP:0100957)2.09970012
67True hermaphroditism (HP:0010459)2.09197166
68Biliary tract neoplasm (HP:0100574)2.09082552
69Abnormal hair whorl (HP:0010721)2.08784073
70Agnosia (HP:0010524)2.08632509
71Nephrogenic diabetes insipidus (HP:0009806)2.08074452
72Neoplasm of the tracheobronchial system (HP:0100552)2.07811687
73Lymphoma (HP:0002665)2.07692718
74Absent frontal sinuses (HP:0002688)2.07644695
75Unilateral renal agenesis (HP:0000122)2.05289925
76Abnormality of the carotid arteries (HP:0005344)2.05026581
77Mild short stature (HP:0003502)2.03895519
78Carpal bone hypoplasia (HP:0001498)2.03492479
79Bone marrow hypocellularity (HP:0005528)2.03107485
80Panhypogammaglobulinemia (HP:0003139)2.02931383
81Asymmetry of the thorax (HP:0001555)2.02571055
82Irregular epiphyses (HP:0010582)2.01860006
83Proximal placement of thumb (HP:0009623)2.01002825
84Congenital primary aphakia (HP:0007707)1.99754946
85Abnormality of the corticospinal tract (HP:0002492)1.97620708
86Chronic diarrhea (HP:0002028)1.96773683
87Abnormality of the labia minora (HP:0012880)1.95496678
88Secondary amenorrhea (HP:0000869)1.95142181
89Clubbing of toes (HP:0100760)1.94289214
90Abnormal platelet volume (HP:0011876)1.94193966
91Long clavicles (HP:0000890)1.94064828
92Increased mean platelet volume (HP:0011877)1.93740480
93Neoplasm of the small intestine (HP:0100833)1.93214087
94Posterior subcapsular cataract (HP:0007787)1.92561521
95Medulloblastoma (HP:0002885)1.92071703
96Premature graying of hair (HP:0002216)1.91903002
97Pulmonary fibrosis (HP:0002206)1.91642974
98Neoplasm of striated muscle (HP:0009728)1.91549844
99Degeneration of anterior horn cells (HP:0002398)1.91118770
100Abnormality of the anterior horn cell (HP:0006802)1.91118770
101Attenuation of retinal blood vessels (HP:0007843)1.90467520
102Renovascular hypertension (HP:0100817)1.89373394
103Astrocytoma (HP:0009592)1.88800948
104Abnormality of the astrocytes (HP:0100707)1.88800948
105Broad distal phalanx of finger (HP:0009836)1.88687333
106Hypoplasia of the thymus (HP:0000778)1.88484574
107Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.88235005
108Acute myeloid leukemia (HP:0004808)1.87552785
109Severe combined immunodeficiency (HP:0004430)1.87412821
110Viral hepatitis (HP:0006562)1.86466382
111Micronodular cirrhosis (HP:0001413)1.85365103
112Microretrognathia (HP:0000308)1.84767561
113Radial bowing (HP:0002986)1.83662172
114Ovarian neoplasm (HP:0100615)1.83341376
115Abnormality of the ileum (HP:0001549)1.83123135
116Fair hair (HP:0002286)1.82446650
117Disinhibition (HP:0000734)1.81611319
118Glioma (HP:0009733)1.81123091
119Poikiloderma (HP:0001029)1.80770546
120Thyroid-stimulating hormone excess (HP:0002925)1.80576410
121Abnormality of midbrain morphology (HP:0002418)1.80565836
122Molar tooth sign on MRI (HP:0002419)1.80565836
123Lower limb hyperreflexia (HP:0002395)1.80180112
124Rough bone trabeculation (HP:0100670)1.79882935
125Transitional cell carcinoma of the bladder (HP:0006740)1.78872750
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78735528
127Chronic hepatic failure (HP:0100626)1.78703642
128Wrist flexion contracture (HP:0001239)1.77946645
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.77666302
130Pelvic girdle muscle weakness (HP:0003749)1.77582907
131Flat cornea (HP:0007720)1.76662194
132Neoplasm of the thyroid gland (HP:0100031)1.76588714
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.76283795
134Bicuspid aortic valve (HP:0001647)1.76260695
135Cafe-au-lait spot (HP:0000957)1.76186499
136Ependymoma (HP:0002888)1.76082317
137Thickened calvaria (HP:0002684)1.75568532
138Epidermoid cyst (HP:0200040)1.75251336
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.73565611
140Irregular vertebral endplates (HP:0003301)1.73107194
141Basal cell carcinoma (HP:0002671)1.73056612
142Broad palm (HP:0001169)1.72801266
143Genital tract atresia (HP:0001827)1.72626924
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.72572994
145IgM deficiency (HP:0002850)1.72495381
146Palmar hyperkeratosis (HP:0010765)1.71709489
147Disproportionate short-trunk short stature (HP:0003521)1.71589264
148Sloping forehead (HP:0000340)1.71294037
149Hypoplastic labia majora (HP:0000059)1.70942100
150Abnormality of T cell physiology (HP:0011840)1.70656200
151Chromsome breakage (HP:0040012)1.70490454
152Poor coordination (HP:0002370)1.69331978
153Macroorchidism (HP:0000053)1.69283492
154Cerebral hypomyelination (HP:0006808)1.69257472
155Neoplasm of the respiratory system (HP:0100606)1.69045108
156Abnormality of the frontal sinuses (HP:0002687)1.68381312
157Bladder carcinoma (HP:0002862)1.67509150
158Bladder neoplasm (HP:0009725)1.67509150
159Neoplasm of the lung (HP:0100526)1.67235797
160Subacute progressive viral hepatitis (HP:0006572)1.66819839
161Postnatal microcephaly (HP:0005484)1.66734027
162Abnormality of the hip-girdle musculature (HP:0001445)1.66245255
163Abnormality of the musculature of the pelvis (HP:0001469)1.66245255
164Vaginal atresia (HP:0000148)1.66071282
165Cystic hygroma (HP:0000476)1.66039361
166Renal duplication (HP:0000075)1.66028105
167Rhabdomyosarcoma (HP:0002859)1.66020328
168Mesomelia (HP:0003027)1.65972299
169Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65770726
170Deep philtrum (HP:0002002)1.65727555
171Aqueductal stenosis (HP:0002410)1.65358576
172Alveolar cell carcinoma (HP:0006519)1.65119344
173Recurrent viral infections (HP:0004429)1.64424671
174Anal stenosis (HP:0002025)1.63741308
175Oral leukoplakia (HP:0002745)1.63410452
176Low anterior hairline (HP:0000294)1.62876939
177Spinal muscular atrophy (HP:0007269)1.62821301
178Enlarged penis (HP:0000040)1.62747592
179Truncal obesity (HP:0001956)1.61900585
180Hyperinsulinemic hypoglycemia (HP:0000825)1.61816976
181Cerebral aneurysm (HP:0004944)1.61693315
182Pancreatic fibrosis (HP:0100732)1.61526064
183High pitched voice (HP:0001620)1.60476249
184Abnormality of the preputium (HP:0100587)1.59821192
185Selective tooth agenesis (HP:0001592)1.59789426
186Neoplasm of the pancreas (HP:0002894)1.59696112
187Hypoplasia of the odontoid process (HP:0003311)1.59194714
188Short nail (HP:0001799)1.58968477
189Flat capital femoral epiphysis (HP:0003370)1.58375847
190Thoracolumbar scoliosis (HP:0002944)1.58074043
191Abnormality of the vertebral endplates (HP:0005106)1.57409994
192Prominent nose (HP:0000448)1.56943135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.62821977
2ACVR1B4.16253753
3FRK3.98849556
4ERBB33.04084900
5SCYL23.00704996
6EEF2K2.98698543
7CDC72.87372489
8TAOK32.72288082
9MAP3K62.55485007
10BRD42.54235900
11TGFBR12.52819172
12PKN22.42558596
13MST42.15706019
14AKT32.15161515
15NEK22.05980987
16STK38L2.01975776
17WNK31.97050466
18STK101.85409198
19CDK81.82540104
20FLT31.80185651
21FGFR21.78903151
22BMPR21.76128936
23MST1R1.73178831
24BCR1.68852159
25TTK1.67726136
26TLK11.67493453
27IRAK11.67352757
28EIF2AK11.66759553
29WEE11.59943057
30STK391.59228832
31MAP4K11.57173376
32MAP3K141.55199707
33NUAK11.54531642
34MAP3K101.50375332
35MKNK21.45116702
36SRPK11.42124566
37TRIB31.42010226
38MOS1.39171287
39PNCK1.38480359
40DYRK21.32380603
41VRK11.31789978
42JAK11.31081826
43FGFR31.27673694
44PRKCE1.26380786
45BRSK21.25799711
46BUB11.25577150
47TRIM281.22830015
48MAP4K21.22666631
49RPS6KA41.19131808
50TNIK1.18623938
51MAP3K81.17471823
52BMPR1B1.16428457
53AURKB1.11535022
54LRRK21.11099320
55PLK11.10015925
56NEK91.08830105
57RPS6KB21.08254889
58FER1.08236661
59STK241.07879409
60NLK1.07543509
61PBK1.07049208
62ZAP701.06903825
63PLK41.05848416
64CAMKK11.05375157
65MATK1.03701853
66ITK1.01954391
67CDK71.01881554
68JAK31.01341597
69TESK20.99788732
70PIM20.96453902
71CDK40.95697229
72PTK2B0.95513278
73KIT0.95266288
74ATR0.94696832
75CDK90.93590507
76MELK0.93201267
77DYRK30.92049955
78EIF2AK20.91425317
79TSSK60.90324892
80CHEK20.89212836
81IRAK40.88944451
82PIK3CA0.88476040
83DDR20.88215592
84CSF1R0.87809820
85ERBB40.84212921
86RAF10.84123346
87MET0.83740135
88PAK40.82596564
89MAP3K20.82364098
90BTK0.82339381
91HIPK20.81219925
92MKNK10.79936007
93TYRO30.79435790
94PIK3CG0.79433146
95CLK10.78866489
96IKBKE0.77418964
97BRSK10.76694053
98TEC0.76405150
99PIM10.76120279
100TXK0.75982774
101NME20.75627853
102PDGFRA0.75595582
103IKBKB0.75086024
104CHEK10.74537185
105PINK10.74090167
106MAP2K70.72751487
107LIMK10.72138021
108FGFR10.72001957
109TRPM70.70087260
110MAP3K120.68641402
111LATS10.63599866
112OXSR10.63119259
113CSNK1A1L0.59544256
114PRKCQ0.59085167
115PAK20.58765886
116ALK0.57303863
117CDK60.57018987
118CSK0.55937136
119TYK20.53493983
120ATM0.52634675
121PLK30.52236434
122STK40.51604459
123STK30.50747795
124MAP3K40.50007247
125RET0.49994626
126CASK0.48625611
127YES10.48487058
128RPS6KB10.48318294
129CDK20.47259654
130CHUK0.45448218
131SIK10.43807973
132AURKA0.43118475
133SIK30.42727774
134MAP3K50.42008101
135EPHA20.41930494
136CAMKK20.41755062
137LCK0.40352347
138PLK20.40087437
139PTK60.40062247
140RPS6KA50.39732254
141CSNK1G10.39098243
142EIF2AK30.37740546
143CDK30.37628758
144CSNK1D0.37149822
145FGR0.36203910
146ABL10.35324413
147EGFR0.35059178
148MAPK110.34506614
149JAK20.34295639
150BRAF0.34215200
151LYN0.34168694
152PRKG20.34036977
153TESK10.33776915
154NEK10.33393587
155PDGFRB0.33304621
156MAPKAPK20.33251328
157MTOR0.32030452
158MAPKAPK50.31441053
159TTN0.31164461
160CDK10.30954643
161HCK0.27497938

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56364447
2Mismatch repair_Homo sapiens_hsa034303.40677231
3Base excision repair_Homo sapiens_hsa034103.17424753
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91162394
5Cell cycle_Homo sapiens_hsa041102.84465673
6RNA transport_Homo sapiens_hsa030132.65365316
7Spliceosome_Homo sapiens_hsa030402.48073758
8Nucleotide excision repair_Homo sapiens_hsa034202.39614651
9Homologous recombination_Homo sapiens_hsa034402.24311801
10One carbon pool by folate_Homo sapiens_hsa006702.20439212
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16419016
12RNA degradation_Homo sapiens_hsa030182.09755028
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97279838
14Propanoate metabolism_Homo sapiens_hsa006401.97046799
15Protein export_Homo sapiens_hsa030601.89514956
16Non-homologous end-joining_Homo sapiens_hsa034501.84610217
17p53 signaling pathway_Homo sapiens_hsa041151.76920438
18Ribosome_Homo sapiens_hsa030101.76418021
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73965683
20Pyrimidine metabolism_Homo sapiens_hsa002401.71981963
21Systemic lupus erythematosus_Homo sapiens_hsa053221.71437339
22Butanoate metabolism_Homo sapiens_hsa006501.68114817
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66253636
24RNA polymerase_Homo sapiens_hsa030201.64408355
25Sulfur metabolism_Homo sapiens_hsa009201.60919528
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59737040
27mRNA surveillance pathway_Homo sapiens_hsa030151.48546477
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47661342
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47430180
30Viral carcinogenesis_Homo sapiens_hsa052031.46792891
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45540077
32Fatty acid biosynthesis_Homo sapiens_hsa000611.44785737
33Chronic myeloid leukemia_Homo sapiens_hsa052201.42290450
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42076667
35Fanconi anemia pathway_Homo sapiens_hsa034601.40238315
36Pancreatic cancer_Homo sapiens_hsa052121.34988010
37Sphingolipid metabolism_Homo sapiens_hsa006001.31978366
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31845714
39Inositol phosphate metabolism_Homo sapiens_hsa005621.28725400
40N-Glycan biosynthesis_Homo sapiens_hsa005101.25971017
41Basal transcription factors_Homo sapiens_hsa030221.19778887
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.19542090
43Hepatitis B_Homo sapiens_hsa051611.18093549
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.17851924
45Herpes simplex infection_Homo sapiens_hsa051681.17556662
46Colorectal cancer_Homo sapiens_hsa052101.17553546
47Antigen processing and presentation_Homo sapiens_hsa046121.17137405
48Allograft rejection_Homo sapiens_hsa053301.16241587
49Shigellosis_Homo sapiens_hsa051311.15184822
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.13899288
51MicroRNAs in cancer_Homo sapiens_hsa052061.12066264
52Leishmaniasis_Homo sapiens_hsa051401.09980988
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07987767
54Prostate cancer_Homo sapiens_hsa052151.06236431
55Caffeine metabolism_Homo sapiens_hsa002321.05227426
56HTLV-I infection_Homo sapiens_hsa051661.04852250
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04066872
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03692953
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03452526
60Folate biosynthesis_Homo sapiens_hsa007901.01940317
61Epstein-Barr virus infection_Homo sapiens_hsa051691.01608189
62Measles_Homo sapiens_hsa051621.01374797
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00621749
64Selenocompound metabolism_Homo sapiens_hsa004500.99218223
65Notch signaling pathway_Homo sapiens_hsa043300.98388739
66Thyroid cancer_Homo sapiens_hsa052160.97029985
67Small cell lung cancer_Homo sapiens_hsa052220.96575359
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96327667
69Fatty acid metabolism_Homo sapiens_hsa012120.95798751
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.95649872
71Autoimmune thyroid disease_Homo sapiens_hsa053200.94008721
72B cell receptor signaling pathway_Homo sapiens_hsa046620.93593235
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93372603
74Legionellosis_Homo sapiens_hsa051340.92846364
75ABC transporters_Homo sapiens_hsa020100.92758326
76Hepatitis C_Homo sapiens_hsa051600.89862575
77T cell receptor signaling pathway_Homo sapiens_hsa046600.89537427
78Graft-versus-host disease_Homo sapiens_hsa053320.89388321
79Peroxisome_Homo sapiens_hsa041460.87873486
80Apoptosis_Homo sapiens_hsa042100.87171257
81Tryptophan metabolism_Homo sapiens_hsa003800.86176857
82Dorso-ventral axis formation_Homo sapiens_hsa043200.85470350
83Acute myeloid leukemia_Homo sapiens_hsa052210.84700391
84Lysine degradation_Homo sapiens_hsa003100.84081138
85Alcoholism_Homo sapiens_hsa050340.83274834
86Vitamin digestion and absorption_Homo sapiens_hsa049770.82922419
87Fatty acid degradation_Homo sapiens_hsa000710.81148290
88Retinol metabolism_Homo sapiens_hsa008300.80899668
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80619669
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77777821
91Primary immunodeficiency_Homo sapiens_hsa053400.77568264
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75560398
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.73386593
94Prolactin signaling pathway_Homo sapiens_hsa049170.73235467
95mTOR signaling pathway_Homo sapiens_hsa041500.72295186
96Bladder cancer_Homo sapiens_hsa052190.71927046
97Pentose phosphate pathway_Homo sapiens_hsa000300.69981083
98Proteasome_Homo sapiens_hsa030500.69147047
99Adherens junction_Homo sapiens_hsa045200.69074468
100Oocyte meiosis_Homo sapiens_hsa041140.68874804
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.68633031
102Non-small cell lung cancer_Homo sapiens_hsa052230.67398610
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65272682
104Viral myocarditis_Homo sapiens_hsa054160.64618246
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.64268273
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63891440
107Hematopoietic cell lineage_Homo sapiens_hsa046400.63477091
108Influenza A_Homo sapiens_hsa051640.63396312
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61038318
110Purine metabolism_Homo sapiens_hsa002300.60796446
111Asthma_Homo sapiens_hsa053100.59357087
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59248714
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59181623
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58970728
115Toxoplasmosis_Homo sapiens_hsa051450.58087236
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.57651709
117Steroid biosynthesis_Homo sapiens_hsa001000.57648573
118Osteoclast differentiation_Homo sapiens_hsa043800.57139422
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.56961976
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.56714557
121Biosynthesis of amino acids_Homo sapiens_hsa012300.56665293
122Hedgehog signaling pathway_Homo sapiens_hsa043400.55838674
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55219214
124Renin-angiotensin system_Homo sapiens_hsa046140.54003044
125Platelet activation_Homo sapiens_hsa046110.51716767
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51229651
127Other glycan degradation_Homo sapiens_hsa005110.50769524
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49530272
129TGF-beta signaling pathway_Homo sapiens_hsa043500.48699275
130Type I diabetes mellitus_Homo sapiens_hsa049400.48678271
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48444665
132Starch and sucrose metabolism_Homo sapiens_hsa005000.48270127
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47024203
134Chemical carcinogenesis_Homo sapiens_hsa052040.46629493
135Melanoma_Homo sapiens_hsa052180.45533489
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.45109371
137Endometrial cancer_Homo sapiens_hsa052130.43801424
138VEGF signaling pathway_Homo sapiens_hsa043700.43551919
139TNF signaling pathway_Homo sapiens_hsa046680.38366312
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36117286
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33703614
142Ovarian steroidogenesis_Homo sapiens_hsa049130.33668927
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31738231
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30190316
145Malaria_Homo sapiens_hsa051440.29435392
146FoxO signaling pathway_Homo sapiens_hsa040680.29182631
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27994443
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27879963

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