CNBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)9.96714023
2cilium or flagellum-dependent cell motility (GO:0001539)9.76288648
3binding of sperm to zona pellucida (GO:0007339)9.69382831
4epithelial cilium movement (GO:0003351)9.64460862
5motile cilium assembly (GO:0044458)9.42900768
6axonemal dynein complex assembly (GO:0070286)9.19368903
7spermatid development (GO:0007286)8.90763815
8regulation of female gonad development (GO:2000194)8.47668017
9cilium movement (GO:0003341)8.00926968
10single fertilization (GO:0007338)7.68885157
11male meiosis (GO:0007140)7.43092815
12negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.33726028
13sperm capacitation (GO:0048240)7.17217332
14piRNA metabolic process (GO:0034587)6.96959516
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.93297622
16regulation of meiosis I (GO:0060631)6.85902101
17microtubule depolymerization (GO:0007019)6.78356796
18regulation of cilium movement (GO:0003352)6.48235870
19fertilization (GO:0009566)6.34905678
20synaptonemal complex organization (GO:0070193)6.32245478
21synaptonemal complex assembly (GO:0007130)6.22943936
22regulation of retinoic acid receptor signaling pathway (GO:0048385)6.22689994
23regulation of acrosome reaction (GO:0060046)6.09340465
24spermatogenesis (GO:0007283)6.04594440
25male gamete generation (GO:0048232)6.02097521
26organic cation transport (GO:0015695)5.86517161
27spermatid nucleus differentiation (GO:0007289)5.86062306
28gamete generation (GO:0007276)5.56827811
29negative regulation of inclusion body assembly (GO:0090084)5.54979620
30female gamete generation (GO:0007292)5.54330327
31glycine transport (GO:0015816)5.38184182
32retinal cone cell development (GO:0046549)5.31472513
33calcium ion-dependent exocytosis (GO:0017156)5.20131535
34gene silencing by RNA (GO:0031047)5.12663128
35oocyte development (GO:0048599)5.05016298
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.04626687
37ventricular system development (GO:0021591)5.04257146
38regulation of histone H3-K9 methylation (GO:0051570)4.98933881
39germ cell development (GO:0007281)4.89108845
40cell recognition (GO:0008037)4.86627976
41chromosome organization involved in meiosis (GO:0070192)4.85167904
42negative regulation of cAMP-mediated signaling (GO:0043951)4.79048409
43regulation of inclusion body assembly (GO:0090083)4.78749977
44glycerol ether metabolic process (GO:0006662)4.69847920
45regulation of steroid hormone secretion (GO:2000831)4.69003778
46regulation of cell maturation (GO:1903429)4.68268091
47male meiosis I (GO:0007141)4.65559951
48DNA methylation involved in gamete generation (GO:0043046)4.48817062
49chromosome condensation (GO:0030261)4.46506637
50positive regulation of humoral immune response (GO:0002922)4.40457334
51single strand break repair (GO:0000012)4.37856072
52multicellular organismal reproductive process (GO:0048609)4.35329516
53ether metabolic process (GO:0018904)4.34818732
54positive regulation of histone H3-K4 methylation (GO:0051571)4.29584260
55meiotic nuclear division (GO:0007126)4.26988786
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.26523607
57microtubule severing (GO:0051013)4.13472599
58neutrophil activation involved in immune response (GO:0002283)4.12360577
59microtubule polymerization or depolymerization (GO:0031109)4.06560884
60positive regulation of mitotic sister chromatid separation (GO:1901970)4.03733446
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.03733446
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.03733446
63centriole assembly (GO:0098534)4.03553146
64negative regulation of reproductive process (GO:2000242)4.02643431
65DNA packaging (GO:0006323)3.99391777
66negative regulation of histone methylation (GO:0031061)3.97706508
67L-amino acid import (GO:0043092)3.96289358
68sexual reproduction (GO:0019953)3.94237652
69seminiferous tubule development (GO:0072520)3.87755732
70protein kinase C signaling (GO:0070528)3.85051348
71relaxation of smooth muscle (GO:0044557)3.79991084
72regulation of microtubule-based movement (GO:0060632)3.76028759
73positive regulation of uterine smooth muscle contraction (GO:0070474)3.71438335
74left/right pattern formation (GO:0060972)3.69809836
75positive regulation of gastrulation (GO:2000543)3.66036870
76oogenesis (GO:0048477)3.65166951
77chaperone-mediated protein complex assembly (GO:0051131)3.64759435
78meiosis I (GO:0007127)3.60344290
79multicellular organismal development (GO:0007275)3.54339991
80monoubiquitinated protein deubiquitination (GO:0035520)3.54091391
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50074593
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50074593
83positive regulation by organism of defense response of other organism involved in symbiotic interact3.50074593
84modulation by symbiont of host immune response (GO:0052553)3.50074593
85positive regulation by symbiont of host defense response (GO:0052509)3.50074593
86modulation by symbiont of host defense response (GO:0052031)3.50074593
87phosphorelay signal transduction system (GO:0000160)3.48121164
88centriole replication (GO:0007099)3.46604537
89protein K11-linked deubiquitination (GO:0035871)3.42236417
90protein localization to cilium (GO:0061512)3.37252085
91meiotic cell cycle (GO:0051321)3.36375725
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35959014
93regulation of centriole replication (GO:0046599)3.32778013
94gene silencing (GO:0016458)3.30870317
95regulation of meiosis (GO:0040020)3.29719530
96alditol metabolic process (GO:0019400)3.29335735
97positive regulation of chromosome segregation (GO:0051984)3.28880089
98synapsis (GO:0007129)3.24810977
99establishment of chromosome localization (GO:0051303)3.18378053
100polyol catabolic process (GO:0046174)3.18244992
101positive regulation of isotype switching (GO:0045830)3.17635449
102amino-acid betaine transport (GO:0015838)3.16176200
103carnitine transport (GO:0015879)3.16176200
104primitive streak formation (GO:0090009)3.15592242
105pyrimidine-containing compound transmembrane transport (GO:0072531)3.15017688
106genitalia morphogenesis (GO:0035112)3.14807000
107detection of molecule of bacterial origin (GO:0032490)3.12909291
108GTP biosynthetic process (GO:0006183)3.10636199
109sister chromatid cohesion (GO:0007062)3.09153731
110interleukin-6-mediated signaling pathway (GO:0070102)3.08742467
111mitotic chromosome condensation (GO:0007076)3.07795624
112glycerol metabolic process (GO:0006071)3.07400584
113DNA alkylation (GO:0006305)3.06877347
114DNA methylation (GO:0006306)3.06877347
115positive regulation of microtubule polymerization (GO:0031116)3.02008674
116carnitine transmembrane transport (GO:1902603)3.01180667
117labyrinthine layer development (GO:0060711)3.01154877
118regulation of mast cell activation involved in immune response (GO:0033006)2.94299934
119nucleoside diphosphate phosphorylation (GO:0006165)2.94102262
120regulation of MHC class II biosynthetic process (GO:0045346)2.94092610
121response to peptidoglycan (GO:0032494)2.93913484
122nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.92762260
123protein localization to chromosome, centromeric region (GO:0071459)2.91862620
124mitotic metaphase plate congression (GO:0007080)2.89089760
125interkinetic nuclear migration (GO:0022027)2.86815843
126N-terminal protein amino acid acetylation (GO:0006474)2.86480463
127intraciliary transport (GO:0042073)2.84996252
128macrophage activation involved in immune response (GO:0002281)2.84367199
129histone H3-K9 demethylation (GO:0033169)2.83986263
130regulation of cytokine production involved in inflammatory response (GO:1900015)2.81978205
131regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81958886
132regulation of spindle checkpoint (GO:0090231)2.80412339
133immunoglobulin mediated immune response (GO:0016064)2.79910293
134somite rostral/caudal axis specification (GO:0032525)2.79827828
135meiotic cell cycle process (GO:1903046)2.79143865
136positive regulation of DNA recombination (GO:0045911)2.75199219
137regulation of meiotic cell cycle (GO:0051445)2.74684743
138regulation of mast cell degranulation (GO:0043304)2.74537524
139regulation of hypersensitivity (GO:0002883)2.73703500
140regulation of sequestering of triglyceride (GO:0010889)2.72300514
141macroautophagy (GO:0016236)2.70965577
142glycolytic process (GO:0006096)2.70915066
143microtubule-based movement (GO:0007018)2.70390633
144positive regulation of reproductive process (GO:2000243)2.69863442
145regulation of uterine smooth muscle contraction (GO:0070472)2.69199648
146positive regulation of mast cell activation (GO:0033005)2.68958596
147UTP biosynthetic process (GO:0006228)2.68661029
148protein polyglutamylation (GO:0018095)2.68249905
149single-organism membrane fusion (GO:0044801)2.68039663
150sequestering of actin monomers (GO:0042989)2.67730524
151regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66500297
152negative regulation of cardiac muscle hypertrophy (GO:0010614)2.64980516
153regulation of histone H3-K4 methylation (GO:0051569)2.63498822
154regulation of mast cell activation (GO:0033003)2.63184483
155cilium organization (GO:0044782)2.62755349
156cellular component assembly involved in morphogenesis (GO:0010927)2.62263416
157protein localization to kinetochore (GO:0034501)2.62220085
158positive regulation of mast cell degranulation (GO:0043306)2.60533469
159positive regulation of mast cell activation involved in immune response (GO:0033008)2.60533469
160cilium assembly (GO:0042384)2.55916255
161nucleus organization (GO:0006997)2.54118892
162negative regulation of execution phase of apoptosis (GO:1900118)2.51556635
163positive regulation of macrophage activation (GO:0043032)2.51358581
164lactate metabolic process (GO:0006089)2.45903350
165protein refolding (GO:0042026)2.41206869
166cilium morphogenesis (GO:0060271)2.40614929
167UTP metabolic process (GO:0046051)2.38169122
168mitotic sister chromatid cohesion (GO:0007064)2.38096859
169quaternary ammonium group transport (GO:0015697)2.35836977
170cell wall macromolecule catabolic process (GO:0016998)15.6396951
171cell wall macromolecule metabolic process (GO:0044036)15.6396951
172fusion of sperm to egg plasma membrane (GO:0007342)15.2027288
173sperm motility (GO:0030317)12.5564052
174multicellular organism reproduction (GO:0032504)12.2417838
175plasma membrane fusion (GO:0045026)11.6035606
176acrosome assembly (GO:0001675)11.5637739
177sperm-egg recognition (GO:0035036)11.3411482
178acrosome reaction (GO:0007340)10.7588428
179reproduction (GO:0000003)10.3974711
180cell-cell recognition (GO:0009988)10.1293687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.08854780
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.26453164
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61684870
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.50954655
5EZH2_22144423_ChIP-Seq_EOC_Human3.09566895
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.00738268
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.00738268
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.00738268
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.89721378
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.70174494
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.65648377
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64938935
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59177823
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55708990
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50938194
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46129784
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.36223938
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.33967473
19VDR_22108803_ChIP-Seq_LS180_Human2.31952505
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.24382412
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21347658
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17475897
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.17384480
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08010446
25KAP1_22055183_ChIP-Seq_ESCs_Mouse2.06662211
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.98186968
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.97366329
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.96287064
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.94567550
30KDM2B_26808549_Chip-Seq_REH_Human1.88468137
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85226157
32STAT1_17558387_ChIP-Seq_HELA_Human1.85097764
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82313640
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.81634498
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.78984284
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76684061
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75679388
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.75375402
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73260919
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68896977
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67372525
42CBP_20019798_ChIP-Seq_JUKART_Human1.67372525
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65762205
44VDR_24787735_ChIP-Seq_THP-1_Human1.63334315
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61378763
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.60199930
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60022065
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59790297
49IRF1_19129219_ChIP-ChIP_H3396_Human1.59711004
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.58045645
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.57486061
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55212818
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54249018
54* GBX2_23144817_ChIP-Seq_PC3_Human1.54068584
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.53014996
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.51616167
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.51132572
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.50486187
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.50258421
60P53_22387025_ChIP-Seq_ESCs_Mouse1.49080325
61ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48108264
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.47215101
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.46875499
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45733482
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.44910266
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43129827
67ZNF274_21170338_ChIP-Seq_K562_Hela1.42184086
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42070991
69RUNX_20019798_ChIP-Seq_JUKART_Human1.40236205
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39862663
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39705599
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.38980271
73P300_18555785_Chip-Seq_ESCs_Mouse1.37956966
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35256441
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34142264
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34032382
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.33372765
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.30829687
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30241281
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.30157488
81GF1_26923725_Chip-Seq_HPCs_Mouse1.29279522
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28817391
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28508040
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27946798
85P300_19829295_ChIP-Seq_ESCs_Human1.27899720
86STAT3_23295773_ChIP-Seq_U87_Human1.27286413
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26627433
88SMRT_27268052_Chip-Seq_Bcells_Human1.25730521
89* TCF4_23295773_ChIP-Seq_U87_Human1.25506402
90FUS_26573619_Chip-Seq_HEK293_Human1.25500165
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.25264082
92REST_21632747_ChIP-Seq_MESCs_Mouse1.23488620
93* SMAD4_21799915_ChIP-Seq_A2780_Human1.22788713
94ERG_20517297_ChIP-Seq_VCAP_Human1.22076218
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20742085
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20444706
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.19994060
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19930108
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.19793249
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19719303
101P53_21459846_ChIP-Seq_SAOS-2_Human1.19614222
102RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19121941
103PU1_27457419_Chip-Seq_LIVER_Mouse1.18892035
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18614613
105RUNX2_22187159_ChIP-Seq_PCA_Human1.17564193
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.17270233
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16917413
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16803767
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16803767
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.15765794
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14128839
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13457919
113HTT_18923047_ChIP-ChIP_STHdh_Human1.13059790
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12984180
115SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12716150
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12436612
117ZFX_18555785_Chip-Seq_ESCs_Mouse1.12405451
118* AR_25329375_ChIP-Seq_VCAP_Human1.10425290
119* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10355693
120RNF2_27304074_Chip-Seq_NSC_Mouse1.10217278
121* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08149030
122TAF15_26573619_Chip-Seq_HEK293_Human1.08108759
123RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07347136
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06581225
125NFYB_21822215_ChIP-Seq_K562_Human1.05139922
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.05056482
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.04360364
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04000172
129IRF8_22096565_ChIP-ChIP_GC-B_Human1.03952449
130ESET_19884257_ChIP-Seq_ESCs_Mouse1.03900704
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03411494
132GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02726975
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02477355
134* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01713698
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01231633
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00247999
137MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00187368
138FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99697836
139* SALL4_22934838_ChIP-ChIP_CD34+_Human0.98950269
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98910265
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98895025
142GF1B_26923725_Chip-Seq_HPCs_Mouse0.98394516
143LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98368297
144* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97701938
145GATA3_26560356_Chip-Seq_TH1_Human0.97134013
146DROSHA_22980978_ChIP-Seq_HELA_Human0.96991166
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.96741496
148* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96676366
149IGF1R_20145208_ChIP-Seq_DFB_Human0.96344451
150BCAT_22108803_ChIP-Seq_LS180_Human0.95675050
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95232415
152NANOG_20526341_ChIP-Seq_ESCs_Human0.94635278
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94361113
154* ARNT_22903824_ChIP-Seq_MCF-7_Human0.94245532
155SOX9_26525672_Chip-Seq_HEART_Mouse0.94231997
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93957512
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93639501
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93515079
159SALL1_21062744_ChIP-ChIP_HESCs_Human0.93396895
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93070601
161EP300_21415370_ChIP-Seq_HL-1_Mouse0.92850596
162* AHR_22903824_ChIP-Seq_MCF-7_Human0.92215936
163SOX2_19829295_ChIP-Seq_ESCs_Human0.92199917
164NANOG_19829295_ChIP-Seq_ESCs_Human0.92199917
165* ER_23166858_ChIP-Seq_MCF-7_Human0.91944589
166CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91316076
167PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90455994
168VDR_24763502_ChIP-Seq_THP-1_Human0.89557570
169VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88402674
170FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87315782
171EWS_26573619_Chip-Seq_HEK293_Human0.85131547
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85016385
173FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83547640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.86148621
2MP0003698_abnormal_male_reproductive5.81388624
3MP0001929_abnormal_gametogenesis5.34379122
4MP0008877_abnormal_DNA_methylation3.75472224
5MP0006292_abnormal_olfactory_placode3.70330728
6MP0008789_abnormal_olfactory_epithelium3.54891855
7MP0002210_abnormal_sex_determination3.35455783
8MP0002138_abnormal_hepatobiliary_system3.35455349
9MP0005395_other_phenotype3.22215515
10MP0002161_abnormal_fertility/fecundity3.18988192
11MP0008057_abnormal_DNA_replication3.05354645
12MP0005394_taste/olfaction_phenotype3.03363983
13MP0005499_abnormal_olfactory_system3.03363983
14MP0005670_abnormal_white_adipose3.03180291
15MP0003646_muscle_fatigue2.86830015
16MP0003183_abnormal_peptide_metabolism2.74994525
17MP0002653_abnormal_ependyma_morphology2.72735441
18MP0001145_abnormal_male_reproductive2.71708562
19MP0000653_abnormal_sex_gland2.50145838
20MP0010234_abnormal_vibrissa_follicle2.11988638
21MP0003879_abnormal_hair_cell2.00960416
22MP0005410_abnormal_fertilization15.2030511
23MP0001986_abnormal_taste_sensitivity1.98831807
24MP0006082_CNS_inflammation1.78212091
25MP0002139_abnormal_hepatobiliary_system1.70174756
26MP0002102_abnormal_ear_morphology1.60121829
27MP0002419_abnormal_innate_immunity1.59858078
28MP0001835_abnormal_antigen_presentation1.55933525
29MP0002234_abnormal_pharynx_morphology1.47301837
30MP0009697_abnormal_copulation1.45862833
31MP0004233_abnormal_muscle_weight1.42018907
32MP0002638_abnormal_pupillary_reflex1.41509806
33MP0005666_abnormal_adipose_tissue1.33864762
34MP0002971_abnormal_brown_adipose1.33297240
35MP0000427_abnormal_hair_cycle1.32396328
36MP0005623_abnormal_meninges_morphology1.31939455
37MP0003436_decreased_susceptibility_to1.31271325
38MP0000569_abnormal_digit_pigmentation1.26495821
39MP0008961_abnormal_basal_metabolism1.25840276
40MP0005535_abnormal_body_temperature1.21187291
41MP0002160_abnormal_reproductive_system1.21012989
42MP0005075_abnormal_melanosome_morpholog1.19925184
43MP0001765_abnormal_ion_homeostasis1.18641669
44MP0006036_abnormal_mitochondrial_physio1.17511147
45MP0003077_abnormal_cell_cycle1.16590989
46MP0003693_abnormal_embryo_hatching1.15734989
47MP0004043_abnormal_pH_regulation1.15222392
48MP0002132_abnormal_respiratory_system1.14652332
49MP0004142_abnormal_muscle_tone1.13011361
50MP0002452_abnormal_antigen_presenting1.10279507
51MP0010307_abnormal_tumor_latency1.09318879
52MP0005647_abnormal_sex_gland1.08245678
53MP0004381_abnormal_hair_follicle1.07232487
54MP0002736_abnormal_nociception_after1.07143079
55MP0001800_abnormal_humoral_immune1.07085740
56MP0002420_abnormal_adaptive_immunity1.05054403
57MP0002723_abnormal_immune_serum1.03030406
58MP0003195_calcinosis1.02135975
59MP0009046_muscle_twitch1.01954008
60MP0001819_abnormal_immune_cell1.01320356
61MP0003303_peritoneal_inflammation1.00951189
62MP0005310_abnormal_salivary_gland0.99220595
63MP0002282_abnormal_trachea_morphology0.96630109
64MP0008260_abnormal_autophagy0.96316477
65MP0003011_delayed_dark_adaptation0.93788549
66MP0009840_abnormal_foam_cell0.91967104
67MP0005025_abnormal_response_to0.91024838
68MP0002148_abnormal_hypersensitivity_rea0.90323637
69MP0004130_abnormal_muscle_cell0.90027955
70MP0000015_abnormal_ear_pigmentation0.89823221
71MP0002127_abnormal_cardiovascular_syste0.89401822
72MP0000465_gastrointestinal_hemorrhage0.88084553
73MP0008872_abnormal_physiological_respon0.85637744
74MP0005451_abnormal_body_composition0.84658015
75MP0005174_abnormal_tail_pigmentation0.84561513
76MP0005365_abnormal_bile_salt0.84430832
77MP0005000_abnormal_immune_tolerance0.81660245
78MP0003121_genomic_imprinting0.81581151
79MP0002396_abnormal_hematopoietic_system0.81035978
80MP0008058_abnormal_DNA_repair0.80808398
81MP0005646_abnormal_pituitary_gland0.80558637
82MP0010678_abnormal_skin_adnexa0.77847839
83MP0001529_abnormal_vocalization0.77299909
84MP0008004_abnormal_stomach_pH0.76825483
85MP0006035_abnormal_mitochondrial_morpho0.74936423
86MP0005085_abnormal_gallbladder_physiolo0.73570409
87MP0005387_immune_system_phenotype0.72577718
88MP0001790_abnormal_immune_system0.72577718
89MP0002398_abnormal_bone_marrow0.70921342
90MP0001727_abnormal_embryo_implantation0.68923336
91MP0005389_reproductive_system_phenotype0.68046521
92MP0000716_abnormal_immune_system0.67810753
93MP0003656_abnormal_erythrocyte_physiolo0.66931639
94MP0000685_abnormal_immune_system0.66521916
95MP0005636_abnormal_mineral_homeostasis0.65936120
96MP0005464_abnormal_platelet_physiology0.65702050
97MP0000631_abnormal_neuroendocrine_gland0.64443241
98MP0005360_urolithiasis0.64082287
99MP0010030_abnormal_orbit_morphology0.63538450
100MP0005076_abnormal_cell_differentiation0.62956251
101MP0001968_abnormal_touch/_nociception0.60239513
102MP0010094_abnormal_chromosome_stability0.60115967
103MP0004019_abnormal_vitamin_homeostasis0.59969304
104MP0004185_abnormal_adipocyte_glucose0.59804075
105MP0001119_abnormal_female_reproductive0.58338605
106MP0002272_abnormal_nervous_system0.56999080
107MP0003828_pulmonary_edema0.56907223
108MP0003252_abnormal_bile_duct0.56190642
109MP0003699_abnormal_female_reproductive0.56188928
110MP0001664_abnormal_digestion0.55952972
111MP0005551_abnormal_eye_electrophysiolog0.55480030
112MP0002928_abnormal_bile_duct0.55108562
113MP0002735_abnormal_chemical_nociception0.54210239
114MP0002118_abnormal_lipid_homeostasis0.54208454
115MP0001293_anophthalmia0.53521400
116MP0006276_abnormal_autonomic_nervous0.52950361
117MP0003890_abnormal_embryonic-extraembry0.52061406
118MP0009764_decreased_sensitivity_to0.51589594
119MP0008469_abnormal_protein_level0.50601434
120MP0002998_abnormal_bone_remodeling0.50213113
121MP0001963_abnormal_hearing_physiology0.49349804
122MP0001672_abnormal_embryogenesis/_devel0.48111580
123MP0000358_abnormal_cell_content/0.47447970
124MP0005409_darkened_coat_color0.45471796
125MP0005332_abnormal_amino_acid0.40075347
126MP0004036_abnormal_muscle_relaxation0.39425380
127MP0003115_abnormal_respiratory_system0.39414183
128MP0001324_abnormal_eye_pigmentation0.39306210
129MP0003111_abnormal_nucleus_morphology0.38134874
130MP0003724_increased_susceptibility_to0.37120066
131MP0005375_adipose_tissue_phenotype0.36499832
132MP0003186_abnormal_redox_activity0.36358826
133MP0003950_abnormal_plasma_membrane0.34145845
134MP0001764_abnormal_homeostasis0.33961309
135MP0009115_abnormal_fat_cell0.33684842
136MP0003959_abnormal_lean_body0.33396005
137MP0002269_muscular_atrophy0.30592549
138MP0004742_abnormal_vestibular_system0.29121226
139MP0004133_heterotaxia0.28677115
140MP0009785_altered_susceptibility_to0.28305738
141MP0005084_abnormal_gallbladder_morpholo0.28054590
142MP0001984_abnormal_olfaction0.27603412
143MP0005319_abnormal_enzyme/_coenzyme0.26983931
144MP0005187_abnormal_penis_morphology0.26922276
145MP0002970_abnormal_white_adipose0.25987494
146MP0003948_abnormal_gas_homeostasis0.25651148
147MP0005584_abnormal_enzyme/coenzyme_acti0.24958152
148MP0002078_abnormal_glucose_homeostasis0.24667077
149MP0005397_hematopoietic_system_phenotyp0.23969895
150MP0001545_abnormal_hematopoietic_system0.23969895
151MP0002169_no_abnormal_phenotype0.23874381
152MP0002873_normal_phenotype0.23591549
153MP0002295_abnormal_pulmonary_circulatio0.23352131
154MP0005388_respiratory_system_phenotype0.23146818
155MP0002133_abnormal_respiratory_system0.23146818
156MP0000609_abnormal_liver_physiology0.22960750
157MP0009642_abnormal_blood_homeostasis0.22596124
158MP0005253_abnormal_eye_physiology0.20965170
159MP0003690_abnormal_glial_cell0.19847776
160MP0002277_abnormal_respiratory_mucosa0.19752709
161MP0003868_abnormal_feces_composition0.19068347
162MP0003953_abnormal_hormone_level0.18078108
163MP0002693_abnormal_pancreas_physiology0.17894267
164MP0002405_respiratory_system_inflammati0.17888932
165MP0005195_abnormal_posterior_eye0.17714132
166MP0000579_abnormal_nail_morphology0.15120812
167MP0010329_abnormal_lipoprotein_level0.14924154

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.71246555
2Abnormal respiratory epithelium morphology (HP:0012253)9.13382266
3Abnormal respiratory motile cilium morphology (HP:0005938)9.13382266
4Abnormal ciliary motility (HP:0012262)8.28624169
5Rhinitis (HP:0012384)7.46414604
6Chronic bronchitis (HP:0004469)7.03389633
7Infertility (HP:0000789)6.01656464
8Nasal polyposis (HP:0100582)5.68331898
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.91237372
10Abnormality of the nasal mucosa (HP:0000433)4.59653060
11Osteomalacia (HP:0002749)4.58021542
12Malnutrition (HP:0004395)4.50977012
13Bronchiectasis (HP:0002110)4.46586518
14Male infertility (HP:0003251)4.37132031
15Facial hemangioma (HP:0000329)4.00355305
16Bronchitis (HP:0012387)3.97300785
17Nephronophthisis (HP:0000090)3.84291056
18Stomatitis (HP:0010280)3.72193263
19Recurrent sinusitis (HP:0011108)3.65420372
20Abnormality of macrophages (HP:0004311)3.60981590
21Lip pit (HP:0100267)3.59013133
22Oligodactyly (hands) (HP:0001180)3.50285725
23Hypophosphatemic rickets (HP:0004912)3.42209335
24Hypoplasia of the fovea (HP:0007750)3.40403760
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.40403760
26Abdominal situs inversus (HP:0003363)3.38211820
27Abnormality of abdominal situs (HP:0011620)3.38211820
28Tubulointerstitial nephritis (HP:0001970)3.30420356
29Abnormal spermatogenesis (HP:0008669)3.28867617
30Short tibia (HP:0005736)3.25171421
31Septo-optic dysplasia (HP:0100842)3.19853508
32Recurrent bacterial skin infections (HP:0005406)3.18935121
33Recurrent otitis media (HP:0000403)3.14330764
34Myositis (HP:0100614)3.10268382
35Retrobulbar optic neuritis (HP:0100654)3.07688308
36Optic neuritis (HP:0100653)3.07688308
37Fair hair (HP:0002286)3.05473767
38Loss of speech (HP:0002371)3.03459676
39Recurrent abscess formation (HP:0002722)3.00051802
40Medial flaring of the eyebrow (HP:0010747)2.99102211
41Abnormality of the renal medulla (HP:0100957)2.93067634
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.87787770
43Orchitis (HP:0100796)2.86982202
44Absent septum pellucidum (HP:0001331)2.84159434
45Abnormality of the fovea (HP:0000493)2.83783387
46Median cleft lip (HP:0000161)2.77252402
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75795058
48Conjunctival telangiectasia (HP:0000524)2.75582160
49Premature ovarian failure (HP:0008209)2.59477282
50Abnormality of the septum pellucidum (HP:0007375)2.57775487
51Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53643523
52Gastrointestinal infarctions (HP:0005244)2.51813591
53Enlarged penis (HP:0000040)2.50079722
54Aplasia/Hypoplasia of the macula (HP:0008059)2.49523170
55Apathy (HP:0000741)2.49209213
56Capillary hemangiomas (HP:0005306)2.48596284
57Anterior segment dysgenesis (HP:0007700)2.47934081
58Congenital sensorineural hearing impairment (HP:0008527)2.47482567
59Lower limb hyperreflexia (HP:0002395)2.47194016
60Diminished motivation (HP:0000745)2.46661078
61Wrist flexion contracture (HP:0001239)2.41929607
62Azoospermia (HP:0000027)2.41743997
63Oligodactyly (HP:0012165)2.40966004
64Tubulointerstitial abnormality (HP:0001969)2.40417735
65Generalized hypopigmentation of hair (HP:0011358)2.39369362
66Episodic fever (HP:0001954)2.38265914
67Eczematoid dermatitis (HP:0000976)2.31226649
68Stillbirth (HP:0003826)2.29911268
69Keratoconjunctivitis sicca (HP:0001097)2.28388497
70Recurrent gram-negative bacterial infections (HP:0005420)2.27891226
71Tubular atrophy (HP:0000092)2.26671734
72Keratoconjunctivitis (HP:0001096)2.26142970
73Aplasia/Hypoplasia affecting the retina (HP:0008061)2.24644326
74Truncal obesity (HP:0001956)2.20319124
75Metaphyseal irregularity (HP:0003025)2.19147227
76Abnormality of the renal cortex (HP:0011035)2.16312179
77Molar tooth sign on MRI (HP:0002419)2.13774151
78Abnormality of midbrain morphology (HP:0002418)2.13774151
79Attenuation of retinal blood vessels (HP:0007843)2.13220164
80Anhidrosis (HP:0000970)2.13216429
81Urethral obstruction (HP:0000796)2.12129722
82Gaze-evoked nystagmus (HP:0000640)2.09545157
83Heterotopia (HP:0002282)2.09068336
84Gait imbalance (HP:0002141)2.07390987
85Limb hypertonia (HP:0002509)2.07172343
86Congenital primary aphakia (HP:0007707)2.06413655
87Thyroid carcinoma (HP:0002890)2.04585546
88Absent/shortened dynein arms (HP:0200106)13.2533265
89Dynein arm defect of respiratory motile cilia (HP:0012255)13.2533265
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8687021
91Hypochromic microcytic anemia (HP:0004840)1.99379560
92Muscle stiffness (HP:0003552)1.98616257
93Cranial hyperostosis (HP:0004437)1.98270001
94Chromsome breakage (HP:0040012)1.97564411
95Periodontitis (HP:0000704)1.97428885
96Impulsivity (HP:0100710)1.97290346
97Striae distensae (HP:0001065)1.96488379
98Toxemia of pregnancy (HP:0100603)1.96394020
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95608995
100Recurrent bronchitis (HP:0002837)1.93241552
101Stage 5 chronic kidney disease (HP:0003774)1.90211104
102Abnormality of the labia minora (HP:0012880)1.89421414
103Posterior subcapsular cataract (HP:0007787)1.86336247
104Gonadotropin excess (HP:0000837)1.84973744
105Neurodegeneration (HP:0002180)1.84458461
106Bony spicule pigmentary retinopathy (HP:0007737)1.83399592
107Supernumerary spleens (HP:0009799)1.83246808
108Hemoptysis (HP:0002105)1.81916011
109Osteomyelitis (HP:0002754)1.81857161
110Nausea (HP:0002018)1.81136796
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.80951450
112Abnormal hemoglobin (HP:0011902)1.80624057
113Abnormality of calcium-phosphate metabolism (HP:0100530)1.79698141
114Bundle branch block (HP:0011710)1.79363323
115Peritonitis (HP:0002586)1.79066853
116Recurrent fungal infections (HP:0002841)1.78677246
117Generalized aminoaciduria (HP:0002909)1.78673782
118Elevated erythrocyte sedimentation rate (HP:0003565)1.77464911
119Prostate neoplasm (HP:0100787)1.76768002
120Abnormality of the phalanges of the hallux (HP:0010057)1.74403260
121Nephrogenic diabetes insipidus (HP:0009806)1.74289078
122Abnormal gallbladder physiology (HP:0012438)1.71331175
123Cholecystitis (HP:0001082)1.71331175
124Aplasia/Hypoplasia of the lens (HP:0008063)1.69757881
125Chronic sinusitis (HP:0011109)1.68818068
126Spastic tetraparesis (HP:0001285)1.65341276
127Optic nerve hypoplasia (HP:0000609)1.63395416
128Postaxial foot polydactyly (HP:0001830)1.59397196
129Cerebellar dysplasia (HP:0007033)1.59210142
130Renal cortical cysts (HP:0000803)1.58594468
131Asymmetric septal hypertrophy (HP:0001670)1.58048134
132Tubulointerstitial fibrosis (HP:0005576)1.57967632
133Sensory axonal neuropathy (HP:0003390)1.56984384
134Type 2 muscle fiber atrophy (HP:0003554)1.56647501
135Congenital malformation of the right heart (HP:0011723)1.55169612
136Double outlet right ventricle (HP:0001719)1.55169612
137Poor coordination (HP:0002370)1.54955662
138Decreased central vision (HP:0007663)1.53730792
139Vascular calcification (HP:0004934)1.53560805
140Abnormality of the neuromuscular junction (HP:0003398)1.49947269
141Fatigable weakness (HP:0003473)1.49947269
142Vaginal atresia (HP:0000148)1.49284003
143Rhabdomyolysis (HP:0003201)1.47086345
144Genital tract atresia (HP:0001827)1.46789689
145Tongue fasciculations (HP:0001308)1.46593160
146Hemorrhage of the eye (HP:0011885)1.46536104
147Cone-rod dystrophy (HP:0000548)1.46332942
148Dyschromatopsia (HP:0007641)1.45647456
149Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.44579212
150Postaxial hand polydactyly (HP:0001162)1.43503392
151Easy fatigability (HP:0003388)1.42112215
152Abnormality of the dental root (HP:0006486)1.41933837
153Taurodontia (HP:0000679)1.41933837
154Abnormality of permanent molar morphology (HP:0011071)1.41933837
155Abnormality of renal excretion (HP:0011036)1.39442239
156Abnormality of saccadic eye movements (HP:0000570)1.37689829
157Cardiovascular calcification (HP:0011915)1.37454638
158Congenital hepatic fibrosis (HP:0002612)1.37247419
159Abnormality of renal resorption (HP:0011038)1.36836181
160Abnormality of macular pigmentation (HP:0008002)1.36366710
161Myoglobinuria (HP:0002913)1.36197073
162Weak cry (HP:0001612)1.35739613
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.35709057
164Hyperphosphatemia (HP:0002905)1.34141729
165Muscle fibrillation (HP:0010546)1.33183027
166Abnormality of molar morphology (HP:0011070)1.32912349
167Abnormality of molar (HP:0011077)1.32912349
168Bile duct proliferation (HP:0001408)1.31169494
169Abnormal biliary tract physiology (HP:0012439)1.31169494
170Proximal tubulopathy (HP:0000114)1.28770224
171Renal dysplasia (HP:0000110)1.27132905
172Abnormality of the dental pulp (HP:0006479)1.26504813
173Oculomotor apraxia (HP:0000657)1.23730810
174Abnormality of ocular smooth pursuit (HP:0000617)1.21593577
175Muscle fiber atrophy (HP:0100295)1.20491464
176Aplasia/Hypoplasia of the tibia (HP:0005772)1.20209940
177Papillary thyroid carcinoma (HP:0002895)1.20154142
178Microglossia (HP:0000171)1.17115637
179Abnormality of aspartate family amino acid metabolism (HP:0010899)1.16655427
180Polydipsia (HP:0001959)1.16237364
181Abnormal drinking behavior (HP:0030082)1.16237364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.23076602
2PDK39.23076602
3PDK25.95145204
4MAP3K135.76001340
5MAP3K95.30110404
6ARAF4.60423754
7TESK13.64559193
8PRKD33.24300274
9ICK2.48271260
10STK38L2.42167528
11PLK42.27509174
12STK392.26654303
13RAF12.14121830
14CDK192.11553550
15CDK92.03180464
16WNK41.87557564
17LATS11.80781691
18TNK21.80168365
19STK381.70753750
20KSR11.65834543
21FRK1.65730354
22NEK21.61212100
23IRAK41.51719278
24PBK1.45667916
25ACVR1B1.45051297
26PTK2B1.40159243
27MET1.28039838
28AURKA1.18907349
29STK31.16137250
30PDK11.10608771
31PIM11.07426649
32CSK1.05460798
33IRAK11.04445851
34MAPK131.03299657
35PRKCI0.99469015
36MAP3K10.98036473
37MARK30.95628828
38JAK30.95226179
39CSF1R0.92407774
40NEK90.92352556
41LMTK20.92214667
42LATS20.90020031
43MAP3K140.89155610
44TTK0.88505657
45MAP2K30.87326863
46LRRK20.86891864
47FES0.85799483
48MAP3K80.82391602
49TYK20.81487961
50CDK70.77799154
51MAP3K30.76833078
52EPHB10.75752345
53PINK10.74365153
54DYRK1B0.69581957
55EIF2AK30.69466722
56PIK3CG0.67427929
57CHEK20.66350620
58IKBKE0.63046496
59HCK0.61893195
60DYRK30.60345327
61PDPK10.60123658
62PNCK0.58071314
63MUSK0.57834790
64NTRK30.57385151
65MAP4K20.55965607
66ZAP700.55836917
67TYRO30.55623779
68TRIM280.54286798
69EPHA30.53586979
70CAMK40.51041465
71MATK0.50936108
72JAK20.47854133
73WNK10.46179234
74BRAF0.46172146
75MAP2K60.45793873
76IKBKB0.44949191
77STK100.44208985
78CCNB10.43317828
79PASK0.42732879
80NUAK10.41975573
81KIT0.41925460
82LYN0.41698991
83PLK20.41092772
84IRAK20.40666352
85EEF2K0.40175744
86SYK0.39048160
87BTK0.38652672
88MAPK10.38037898
89FGR0.37728162
90PKN10.37159913
91CDC70.37157378
92CDK20.36872676
93ZAK0.36602918
94DMPK0.35958355
95BRSK20.35776613
96TAOK10.35054087
97MAPK150.33202641
98TBK10.33045173
99PRKACB0.32924210
100EGFR0.32429641
101CLK10.31222345
102OXSR10.29632483
103PLK10.29164446
104ERBB40.28914015
105MOS0.28320398
106CDK50.27681417
107CHUK0.27551207
108MAP2K10.27202733
109RIPK40.26469501
110CDK30.26098228
111CHEK10.26054510
112PRKCG0.25965872
113TAOK30.25082024
114NME20.23489767
115BMPR20.22217032
116CDK120.21853550
117ATM0.21093898
118WNK30.20980421
119CAMKK10.17825028
120PRKAA10.16816598
121ADRBK10.16398148
122STK240.15894010
123PRKG20.14768090
124EIF2AK10.14299673
125DYRK20.14143838
126PAK10.14045033
127CDK40.13985437
128PRKCQ0.13925628
129AURKB0.12871275
130MAP3K50.11578866
131MAPKAPK50.11496659
132KSR20.11341525
133CAMK2A0.11286012
134PRKCD0.11186314
135MELK0.10483191
136ATR0.08473719
137STK110.08191979
138BMPR1B0.07896546
139YES10.07273212
140NTRK20.06984964
141PRKACG0.06957854
142PRKCA0.06745772
143MAP3K60.05833118
144CSNK1D0.05628350
145TXK0.05074960
146NEK60.04901358
147PRKACA0.03786859
148CSNK2A10.02941706
149PRKG10.02898990
150BRSK10.02372355
151PAK60.02117633
152PRKCZ0.01955645
153TEC0.01119707
154MARK20.01097941
155RPS6KB10.01052322
156RPS6KA10.00443378
157PDGFRB0.00178951
158GSK3B-0.0097269
159MAP2K4-0.0088406
160MAP4K1-0.0049293
161TESK2-0.0022995
162BLK-0.0020762

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.21830823
2Propanoate metabolism_Homo sapiens_hsa006403.94027349
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.88781605
4Pyruvate metabolism_Homo sapiens_hsa006203.66679674
5Fatty acid biosynthesis_Homo sapiens_hsa000613.60880796
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.95676588
7Cell cycle_Homo sapiens_hsa041102.82588992
8PPAR signaling pathway_Homo sapiens_hsa033202.65473883
9Basal transcription factors_Homo sapiens_hsa030222.55578563
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50721230
11Linoleic acid metabolism_Homo sapiens_hsa005912.44218569
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41570956
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.22636452
14Pentose phosphate pathway_Homo sapiens_hsa000302.22554084
15Caffeine metabolism_Homo sapiens_hsa002322.14842644
16Huntingtons disease_Homo sapiens_hsa050162.12601268
17Olfactory transduction_Homo sapiens_hsa047402.12251281
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.12125654
19Glucagon signaling pathway_Homo sapiens_hsa049222.10645590
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.09237439
21Fatty acid degradation_Homo sapiens_hsa000712.07103339
22Selenocompound metabolism_Homo sapiens_hsa004501.95738834
23Leishmaniasis_Homo sapiens_hsa051401.86745601
24Cardiac muscle contraction_Homo sapiens_hsa042601.82752291
25Osteoclast differentiation_Homo sapiens_hsa043801.76883396
26Fatty acid metabolism_Homo sapiens_hsa012121.76704694
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75309737
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71759810
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69978026
30Glycerolipid metabolism_Homo sapiens_hsa005611.65915297
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.63185668
32Fanconi anemia pathway_Homo sapiens_hsa034601.63025463
33Oocyte meiosis_Homo sapiens_hsa041141.61806945
34Carbon metabolism_Homo sapiens_hsa012001.59295713
35Mineral absorption_Homo sapiens_hsa049781.45551250
36Fructose and mannose metabolism_Homo sapiens_hsa000511.41346220
37B cell receptor signaling pathway_Homo sapiens_hsa046621.41158742
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39393453
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37176686
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35052560
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34585910
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34028949
43Asthma_Homo sapiens_hsa053101.32624151
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32058337
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.31747924
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28169757
47Chemokine signaling pathway_Homo sapiens_hsa040621.27922713
48Mismatch repair_Homo sapiens_hsa034301.26200093
49Glutathione metabolism_Homo sapiens_hsa004801.25327873
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24054348
51Tuberculosis_Homo sapiens_hsa051521.23407845
52Ether lipid metabolism_Homo sapiens_hsa005651.20820394
53Homologous recombination_Homo sapiens_hsa034401.19981229
54Influenza A_Homo sapiens_hsa051641.18054744
55Circadian rhythm_Homo sapiens_hsa047101.16283722
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14615411
57Phagosome_Homo sapiens_hsa041451.13387175
58Dorso-ventral axis formation_Homo sapiens_hsa043201.11915206
59Allograft rejection_Homo sapiens_hsa053301.10640706
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09823867
61Herpes simplex infection_Homo sapiens_hsa051681.08375738
62Oxidative phosphorylation_Homo sapiens_hsa001901.05829094
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05010892
64p53 signaling pathway_Homo sapiens_hsa041151.04453459
65Graft-versus-host disease_Homo sapiens_hsa053321.03832222
66Autoimmune thyroid disease_Homo sapiens_hsa053201.03039695
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00818917
68Morphine addiction_Homo sapiens_hsa050321.00123167
69Fatty acid elongation_Homo sapiens_hsa000620.99639569
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98799559
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97240724
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93999789
73FoxO signaling pathway_Homo sapiens_hsa040680.93797383
74Hepatitis B_Homo sapiens_hsa051610.92642126
75Regulation of autophagy_Homo sapiens_hsa041400.90854238
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90743905
77Bile secretion_Homo sapiens_hsa049760.89106553
78T cell receptor signaling pathway_Homo sapiens_hsa046600.88510582
79Ovarian steroidogenesis_Homo sapiens_hsa049130.85861746
80Hematopoietic cell lineage_Homo sapiens_hsa046400.85802136
81Viral carcinogenesis_Homo sapiens_hsa052030.85520118
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.84944836
83Purine metabolism_Homo sapiens_hsa002300.84859326
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84705444
85Chemical carcinogenesis_Homo sapiens_hsa052040.82981759
86Biosynthesis of amino acids_Homo sapiens_hsa012300.82273508
87Parkinsons disease_Homo sapiens_hsa050120.81964292
88Long-term depression_Homo sapiens_hsa047300.81037540
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80996731
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80591039
91Inositol phosphate metabolism_Homo sapiens_hsa005620.80308955
92Gap junction_Homo sapiens_hsa045400.79961484
93Fat digestion and absorption_Homo sapiens_hsa049750.79933643
94Arachidonic acid metabolism_Homo sapiens_hsa005900.78815404
95Toxoplasmosis_Homo sapiens_hsa051450.78561532
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.78533804
97Malaria_Homo sapiens_hsa051440.78351940
98Base excision repair_Homo sapiens_hsa034100.78329325
99Nucleotide excision repair_Homo sapiens_hsa034200.78210106
100Measles_Homo sapiens_hsa051620.75983739
101Staphylococcus aureus infection_Homo sapiens_hsa051500.74529222
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74288139
103Nicotine addiction_Homo sapiens_hsa050330.73623960
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.72833065
105Serotonergic synapse_Homo sapiens_hsa047260.72792003
106Collecting duct acid secretion_Homo sapiens_hsa049660.72589484
107Amphetamine addiction_Homo sapiens_hsa050310.72577213
108Alzheimers disease_Homo sapiens_hsa050100.71951468
109Acute myeloid leukemia_Homo sapiens_hsa052210.71299260
110ABC transporters_Homo sapiens_hsa020100.70759015
111Renal cell carcinoma_Homo sapiens_hsa052110.69933626
112Metabolic pathways_Homo sapiens_hsa011000.69785686
113Phototransduction_Homo sapiens_hsa047440.67898045
114TNF signaling pathway_Homo sapiens_hsa046680.67788232
115Rheumatoid arthritis_Homo sapiens_hsa053230.67204835
116Insulin secretion_Homo sapiens_hsa049110.66800596
117mTOR signaling pathway_Homo sapiens_hsa041500.65124813
118Renin secretion_Homo sapiens_hsa049240.63557507
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62045789
120Non-small cell lung cancer_Homo sapiens_hsa052230.60491330
121African trypanosomiasis_Homo sapiens_hsa051430.58995260
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.58994210
123Other glycan degradation_Homo sapiens_hsa005110.57978990
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57677827
125Platelet activation_Homo sapiens_hsa046110.57566527
126Folate biosynthesis_Homo sapiens_hsa007900.57473523
127ErbB signaling pathway_Homo sapiens_hsa040120.57139511
128Sulfur metabolism_Homo sapiens_hsa009200.56452190
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.56350936
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55630843
131Legionellosis_Homo sapiens_hsa051340.55166978
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54376591
133Amoebiasis_Homo sapiens_hsa051460.53744059
134Salivary secretion_Homo sapiens_hsa049700.52918260
135Prolactin signaling pathway_Homo sapiens_hsa049170.51072734
136Cholinergic synapse_Homo sapiens_hsa047250.51061408
137Thyroid cancer_Homo sapiens_hsa052160.50671935
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50491419
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.50228277
140GABAergic synapse_Homo sapiens_hsa047270.49712749
141Thyroid hormone synthesis_Homo sapiens_hsa049180.49577152
142Calcium signaling pathway_Homo sapiens_hsa040200.47176314
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46511781
144Estrogen signaling pathway_Homo sapiens_hsa049150.46467649
145RNA degradation_Homo sapiens_hsa030180.46454865
146Taste transduction_Homo sapiens_hsa047420.46300807
147Pertussis_Homo sapiens_hsa051330.46221334
148Notch signaling pathway_Homo sapiens_hsa043300.45927174
149Oxytocin signaling pathway_Homo sapiens_hsa049210.45841831
150Type I diabetes mellitus_Homo sapiens_hsa049400.45403618
151Endometrial cancer_Homo sapiens_hsa052130.42099532
152Protein digestion and absorption_Homo sapiens_hsa049740.41564275
153HTLV-I infection_Homo sapiens_hsa051660.41238212
154Complement and coagulation cascades_Homo sapiens_hsa046100.40796735
155Antigen processing and presentation_Homo sapiens_hsa046120.40765816
156Choline metabolism in cancer_Homo sapiens_hsa052310.40699465
157Pancreatic cancer_Homo sapiens_hsa052120.40569931
158MAPK signaling pathway_Homo sapiens_hsa040100.38770884
159mRNA surveillance pathway_Homo sapiens_hsa030150.34113239
160Primary bile acid biosynthesis_Homo sapiens_hsa001200.34084135
161Pancreatic secretion_Homo sapiens_hsa049720.33993359
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33749084
163Peroxisome_Homo sapiens_hsa041460.32780348
164Systemic lupus erythematosus_Homo sapiens_hsa053220.31737917
165AMPK signaling pathway_Homo sapiens_hsa041520.28857862
166Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27627190
167Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26234734
168Gastric acid secretion_Homo sapiens_hsa049710.26145263
169Vascular smooth muscle contraction_Homo sapiens_hsa042700.25973693
170cAMP signaling pathway_Homo sapiens_hsa040240.24973090
171Long-term potentiation_Homo sapiens_hsa047200.22302464
172Synaptic vesicle cycle_Homo sapiens_hsa047210.22168251
173Central carbon metabolism in cancer_Homo sapiens_hsa052300.21813849
174Pyrimidine metabolism_Homo sapiens_hsa002400.18627836
175Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18087947
176RNA transport_Homo sapiens_hsa030130.17989825
177Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16834641
178beta-Alanine metabolism_Homo sapiens_hsa004100.14699422
179Renin-angiotensin system_Homo sapiens_hsa046140.13686234
180Retinol metabolism_Homo sapiens_hsa008300.12390281

Most similar genes based on co-expression Upload to Enrichr

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