CNBD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.07270867
2antigen processing and presentation of endogenous antigen (GO:0019883)4.73067602
3response to pheromone (GO:0019236)4.70418292
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63059840
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63059840
6L-fucose catabolic process (GO:0042355)4.51656529
7fucose catabolic process (GO:0019317)4.51656529
8L-fucose metabolic process (GO:0042354)4.51656529
9cysteine metabolic process (GO:0006534)4.38814353
10tryptophan catabolic process (GO:0006569)4.21065878
11indole-containing compound catabolic process (GO:0042436)4.21065878
12indolalkylamine catabolic process (GO:0046218)4.21065878
13valine metabolic process (GO:0006573)4.14333442
14DNA deamination (GO:0045006)3.99423749
15aromatic amino acid family catabolic process (GO:0009074)3.98898340
16cellular ketone body metabolic process (GO:0046950)3.98833842
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.92526215
18L-phenylalanine catabolic process (GO:0006559)3.92526215
19tryptophan metabolic process (GO:0006568)3.85131160
20protein complex biogenesis (GO:0070271)3.81507244
21L-phenylalanine metabolic process (GO:0006558)3.80572344
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.80572344
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.73124879
24kynurenine metabolic process (GO:0070189)3.68980052
25mitochondrial respiratory chain complex assembly (GO:0033108)3.58434037
26ketone body metabolic process (GO:1902224)3.57202337
27organic cation transport (GO:0015695)3.57161115
28piRNA metabolic process (GO:0034587)3.54962549
29drug transmembrane transport (GO:0006855)3.53326427
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.49862781
31NADH dehydrogenase complex assembly (GO:0010257)3.49862781
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49862781
33respiratory chain complex IV assembly (GO:0008535)3.47836752
34intestinal cholesterol absorption (GO:0030299)3.44754945
35sulfur amino acid catabolic process (GO:0000098)3.43157334
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40873526
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40873526
38protein polyglutamylation (GO:0018095)3.39716147
39homocysteine metabolic process (GO:0050667)3.38705898
40platelet dense granule organization (GO:0060155)3.38466292
41hepatocyte apoptotic process (GO:0097284)3.37167553
42axoneme assembly (GO:0035082)3.32374906
43signal peptide processing (GO:0006465)3.31877634
44water-soluble vitamin biosynthetic process (GO:0042364)3.30990154
45epithelial cilium movement (GO:0003351)3.30974322
46lysine catabolic process (GO:0006554)3.27540258
47lysine metabolic process (GO:0006553)3.27540258
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26959719
49cytochrome complex assembly (GO:0017004)3.26947764
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25875947
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25172527
52cellular modified amino acid catabolic process (GO:0042219)3.22308204
53fructose metabolic process (GO:0006000)3.21991454
54cellular response to exogenous dsRNA (GO:0071360)3.20663963
55drug transport (GO:0015893)3.20610016
56antigen processing and presentation via MHC class Ib (GO:0002475)3.19241026
57preassembly of GPI anchor in ER membrane (GO:0016254)3.15235905
58peptide catabolic process (GO:0043171)3.14974210
59ubiquinone biosynthetic process (GO:0006744)3.14925225
60negative regulation of telomere maintenance (GO:0032205)3.13973132
61UDP-N-acetylglucosamine metabolic process (GO:0006047)3.13360304
62ATP synthesis coupled proton transport (GO:0015986)3.12684397
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12684397
64regulation of cilium movement (GO:0003352)3.12229377
65urate metabolic process (GO:0046415)3.12154165
66protein-cofactor linkage (GO:0018065)3.10681412
67DNA methylation involved in gamete generation (GO:0043046)3.09741043
68behavioral response to ethanol (GO:0048149)3.07033456
69mannosylation (GO:0097502)3.06320707
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99899593
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98092938
72detection of light stimulus involved in sensory perception (GO:0050962)2.96852710
73detection of light stimulus involved in visual perception (GO:0050908)2.96852710
74ubiquinone metabolic process (GO:0006743)2.95985274
75amine catabolic process (GO:0009310)2.93591880
76cellular biogenic amine catabolic process (GO:0042402)2.93591880
77neuronal action potential (GO:0019228)2.92207878
78amino-acid betaine metabolic process (GO:0006577)2.91726415
79complement activation, classical pathway (GO:0006958)2.90085291
80protein retention in ER lumen (GO:0006621)2.87648672
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87642821
82sperm motility (GO:0030317)2.87087549
83pyrimidine ribonucleoside catabolic process (GO:0046133)2.85667319
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83442620
85indole-containing compound metabolic process (GO:0042430)2.83345336
86primary amino compound metabolic process (GO:1901160)2.82960542
87alanine transport (GO:0032328)2.82906461
88regulation of glucokinase activity (GO:0033131)2.81860691
89regulation of hexokinase activity (GO:1903299)2.81860691
90male meiosis I (GO:0007141)2.81176768
91urea cycle (GO:0000050)2.80004731
92urea metabolic process (GO:0019627)2.80004731
93response to nitrosative stress (GO:0051409)2.78916704
94transcytosis (GO:0045056)2.78818578
95indolalkylamine metabolic process (GO:0006586)2.77378879
96branched-chain amino acid metabolic process (GO:0009081)2.76497916
97benzene-containing compound metabolic process (GO:0042537)2.76270026
98nonmotile primary cilium assembly (GO:0035058)2.75777214
99regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75359073
100aromatic amino acid family metabolic process (GO:0009072)2.75344138
101glyoxylate metabolic process (GO:0046487)2.74954298
102positive regulation of gamma-delta T cell activation (GO:0046645)2.72249327
103cilium movement (GO:0003341)2.70998672
104sulfation (GO:0051923)2.67556119
105negative regulation of mast cell activation (GO:0033004)2.67493487
106electron transport chain (GO:0022900)2.66696528
107serine family amino acid catabolic process (GO:0009071)2.66342300
108exocrine pancreas development (GO:0031017)2.64417748
109rhodopsin mediated signaling pathway (GO:0016056)2.64178764
110S-adenosylmethionine metabolic process (GO:0046500)2.63987818
111multicellular organism reproduction (GO:0032504)2.63653924
112alpha-linolenic acid metabolic process (GO:0036109)2.62628192
113regulation of meiosis I (GO:0060631)2.61972163
114respiratory electron transport chain (GO:0022904)2.58931891
1152-oxoglutarate metabolic process (GO:0006103)2.57902455
116nitrogen cycle metabolic process (GO:0071941)2.57294906
117regulation of podosome assembly (GO:0071801)2.56525622
118regulation of action potential (GO:0098900)2.55437346
119serotonin metabolic process (GO:0042428)2.54375102
120complement activation, alternative pathway (GO:0006957)2.54220181
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.53757961
122fusion of sperm to egg plasma membrane (GO:0007342)2.53412948
123complement activation (GO:0006956)2.53314171
124regulation of triglyceride catabolic process (GO:0010896)2.52857880
125proton transport (GO:0015992)2.52740105
126L-methionine salvage (GO:0071267)2.52098467
127L-methionine biosynthetic process (GO:0071265)2.52098467
128amino acid salvage (GO:0043102)2.52098467
129alpha-amino acid catabolic process (GO:1901606)2.51485736
130aminoglycoside antibiotic metabolic process (GO:0030647)2.51333125
131serine family amino acid metabolic process (GO:0009069)2.50827457
132glycerophospholipid catabolic process (GO:0046475)2.50806649
133hydrogen ion transmembrane transport (GO:1902600)2.50774597
134cilium organization (GO:0044782)2.50755988
135response to type I interferon (GO:0034340)2.50443566
136GPI anchor metabolic process (GO:0006505)2.50126821
137positive regulation of prostaglandin secretion (GO:0032308)2.48869699
138hydrogen transport (GO:0006818)2.48217535
139regulation of interferon-beta biosynthetic process (GO:0045357)2.47745920
140quinone biosynthetic process (GO:1901663)2.47625616
141type I interferon signaling pathway (GO:0060337)2.46860848
142cellular response to type I interferon (GO:0071357)2.46860848
143positive regulation of B cell differentiation (GO:0045579)2.46791652
144response to interferon-beta (GO:0035456)2.46492867
145cilium morphogenesis (GO:0060271)2.46212887
146xenobiotic catabolic process (GO:0042178)2.46110620
147cilium or flagellum-dependent cell motility (GO:0001539)2.45975121
148cellular amino acid catabolic process (GO:0009063)2.45647508
149reverse cholesterol transport (GO:0043691)2.45006867
150protein localization to cilium (GO:0061512)2.44801535
151mechanosensory behavior (GO:0007638)2.44132272
152peptidyl-histidine modification (GO:0018202)2.44107306
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43389971
154positive regulation of interferon-alpha production (GO:0032727)2.42734583
155cilium assembly (GO:0042384)2.42297627
156synaptic transmission, cholinergic (GO:0007271)2.41624348
157positive regulation of meiosis (GO:0045836)2.41432476
158disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.41025403
159killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.41025403
160branched-chain amino acid catabolic process (GO:0009083)2.40860279
161photoreceptor cell maintenance (GO:0045494)2.40782131
162triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40768935
163intestinal absorption (GO:0050892)2.40546694
164bile acid biosynthetic process (GO:0006699)2.40313368
165nephron epithelium morphogenesis (GO:0072088)2.38860190
166nephron tubule morphogenesis (GO:0072078)2.38860190
167synapsis (GO:0007129)2.38514404
168regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38094622
169COPI coating of Golgi vesicle (GO:0048205)2.37793597
170Golgi transport vesicle coating (GO:0048200)2.37793597
171establishment of protein localization to mitochondrial membrane (GO:0090151)2.37764848
172somite rostral/caudal axis specification (GO:0032525)2.37733085
173phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37724008
174reflex (GO:0060004)2.35053898
175digestion (GO:0007586)2.34951122
176carnitine metabolic process (GO:0009437)2.34711712
177serine family amino acid biosynthetic process (GO:0009070)2.34589546
178regulation of natural killer cell differentiation (GO:0032823)2.34425636
179phenylpropanoid metabolic process (GO:0009698)2.34178905
180proline metabolic process (GO:0006560)2.33106564
181glutathione derivative biosynthetic process (GO:1901687)2.33102372
182glutathione derivative metabolic process (GO:1901685)2.33102372
183fatty acid beta-oxidation (GO:0006635)2.32415430
184negative regulation of cholesterol transport (GO:0032375)2.32257594
185negative regulation of sterol transport (GO:0032372)2.32257594
186regulation of cholesterol homeostasis (GO:2000188)2.32045511
187regulation of interferon-alpha production (GO:0032647)2.31924741
188ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.30494748
189short-chain fatty acid metabolic process (GO:0046459)2.29887480
190killing of cells of other organism (GO:0031640)2.28663353
191disruption of cells of other organism (GO:0044364)2.28663353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.29361930
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.00710452
3ZNF274_21170338_ChIP-Seq_K562_Hela4.47931043
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.96562093
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74857944
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.57854214
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.36330913
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.10133064
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.08921606
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.05183731
11VDR_22108803_ChIP-Seq_LS180_Human2.94457658
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.78521226
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75680206
14GBX2_23144817_ChIP-Seq_PC3_Human2.65169354
15IGF1R_20145208_ChIP-Seq_DFB_Human2.56881850
16GATA1_22025678_ChIP-Seq_K562_Human2.48713345
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.48596083
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46162911
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42387596
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.42226394
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.33215709
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31729954
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30993069
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27386073
25EZH2_22144423_ChIP-Seq_EOC_Human2.26575273
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.25666948
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24086993
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23291812
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18687311
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18375799
31POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17082149
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16413160
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11930594
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.11326456
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09795595
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05303901
37FUS_26573619_Chip-Seq_HEK293_Human2.03482086
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02311231
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98838730
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97618963
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93755188
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93504889
43EWS_26573619_Chip-Seq_HEK293_Human1.92984442
44TAF15_26573619_Chip-Seq_HEK293_Human1.89721110
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89609627
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89320633
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84777876
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84536534
49P300_19829295_ChIP-Seq_ESCs_Human1.82939811
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82387169
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.79427842
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79178337
53ER_23166858_ChIP-Seq_MCF-7_Human1.78123263
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.77977404
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76908933
56TP53_22573176_ChIP-Seq_HFKS_Human1.69810284
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.69686333
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68904711
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.67211449
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66964978
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66923977
62MYB_26560356_Chip-Seq_TH2_Human1.66319758
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66195349
64RUNX_20019798_ChIP-Seq_JUKART_Human1.63598698
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61439220
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60113766
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59198408
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58988126
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57681278
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54638538
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53929623
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53058342
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52909845
74GATA4_25053715_ChIP-Seq_YYC3_Human1.52338623
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51048083
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.51048083
77NANOG_19829295_ChIP-Seq_ESCs_Human1.50637568
78SOX2_19829295_ChIP-Seq_ESCs_Human1.50637568
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50212040
80IRF1_19129219_ChIP-ChIP_H3396_Human1.50165077
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.48573261
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47308533
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45426572
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44805027
85AR_25329375_ChIP-Seq_VCAP_Human1.44788833
86SCL_19346495_ChIP-Seq_HPC-7_Human1.42061560
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41703893
88MYB_26560356_Chip-Seq_TH1_Human1.41618813
89CBP_20019798_ChIP-Seq_JUKART_Human1.41557365
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41557365
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.41420002
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41182865
93BCAT_22108803_ChIP-Seq_LS180_Human1.41164348
94SPI1_23547873_ChIP-Seq_NB4_Human1.38275077
95MYC_18940864_ChIP-ChIP_HL60_Human1.37970177
96VDR_23849224_ChIP-Seq_CD4+_Human1.34863357
97REST_21632747_ChIP-Seq_MESCs_Mouse1.33816835
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33220638
99RNF2_27304074_Chip-Seq_NSC_Mouse1.32793753
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32561225
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32079455
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29266715
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.28826309
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27965441
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27875730
106GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27757566
107NCOR_22424771_ChIP-Seq_293T_Human1.26539581
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24876661
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23039189
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23005997
111MAF_26560356_Chip-Seq_TH1_Human1.22314290
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21552808
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21404662
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20464447
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20351212
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20329247
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20043073
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.19776018
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.19355847
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.19321263
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.19065217
122STAT3_23295773_ChIP-Seq_U87_Human1.19062783
123VDR_24763502_ChIP-Seq_THP-1_Human1.18484341
124ELK1_19687146_ChIP-ChIP_HELA_Human1.18325622
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18085545
126ERA_21632823_ChIP-Seq_H3396_Human1.18079287
127HOXB7_26014856_ChIP-Seq_BT474_Human1.18066514
128AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17265658
129SMAD4_21799915_ChIP-Seq_A2780_Human1.16954021
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16760607
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16760607
132RUNX2_22187159_ChIP-Seq_PCA_Human1.15645773
133GATA2_21666600_ChIP-Seq_HMVEC_Human1.15530941
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.14368408
135TCF4_22108803_ChIP-Seq_LS180_Human1.14293817
136MYC_19829295_ChIP-Seq_ESCs_Human1.14222239
137SMAD3_21741376_ChIP-Seq_EPCs_Human1.13959905
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.13646120
139GATA6_25053715_ChIP-Seq_YYC3_Human1.13499338
140TCF4_23295773_ChIP-Seq_U87_Human1.13055356
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12500194
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12375927
143GATA3_27048872_Chip-Seq_THYMUS_Human1.11984408
144ETS1_20019798_ChIP-Seq_JURKAT_Human1.11904236
145HTT_18923047_ChIP-ChIP_STHdh_Human1.11610833
146GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10693271
147TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10292423
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10039256
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09411852
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08600693
151SRF_21415370_ChIP-Seq_HL-1_Mouse1.08114440
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07961850
153CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07129493
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06905811
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06357550
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06339933
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05005730
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04972522
159PU_27001747_Chip-Seq_BMDM_Mouse1.04485111
160FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04465501
161GATA3_26560356_Chip-Seq_TH2_Human1.03097104
162TAF2_19829295_ChIP-Seq_ESCs_Human1.03040313
163CDX2_20551321_ChIP-Seq_CACO-2_Human1.02968175
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01176008
165FOXH1_21741376_ChIP-Seq_EPCs_Human1.00777139
166AR_21572438_ChIP-Seq_LNCaP_Human1.00545671
167FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99135954
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.98525758
169NANOG_20526341_ChIP-Seq_ESCs_Human0.97844492
170KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96930046
171FLI1_21867929_ChIP-Seq_TH2_Mouse0.96641341
172SOX2_20726797_ChIP-Seq_SW620_Human0.95644617
173MYC_22102868_ChIP-Seq_BL_Human0.95601412
174EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95382311
175CRX_20693478_ChIP-Seq_RETINA_Mouse0.95358831
176REST_18959480_ChIP-ChIP_MESCs_Mouse0.94715169
177CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93730348
178UTX_26944678_Chip-Seq_JUKART_Human0.92763465
179BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92462436
180CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91642320
181VDR_24787735_ChIP-Seq_THP-1_Human0.91554979
182FOXA2_19822575_ChIP-Seq_HepG2_Human0.90459617
183ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90142081
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88847185
185EGR1_19032775_ChIP-ChIP_M12_Human0.87770306
186PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87743236
187SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84994770
188PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83664227
189RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83467935
190PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82711156
191AR_20517297_ChIP-Seq_VCAP_Human0.82271331
192STAT1_17558387_ChIP-Seq_HELA_Human0.80464048
193HNF4A_19822575_ChIP-Seq_HepG2_Human0.79435353
194P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78796029
195CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78288595
196CTCF_26484167_Chip-Seq_Bcells_Mouse0.77256110
197GATA2_19941826_ChIP-Seq_K562_Human0.77177866
198RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77058939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.11617092
2MP0005360_urolithiasis3.57322884
3MP0005365_abnormal_bile_salt3.42381379
4MP0001835_abnormal_antigen_presentation3.18469241
5MP0001666_abnormal_nutrient_absorption2.96591650
6MP0005085_abnormal_gallbladder_physiolo2.92327057
7MP0002837_dystrophic_cardiac_calcinosis2.75061997
8MP0008877_abnormal_DNA_methylation2.64870050
9MP0002138_abnormal_hepatobiliary_system2.56307257
10MP0003136_yellow_coat_color2.53271582
11MP0002102_abnormal_ear_morphology2.42323107
12MP0008875_abnormal_xenobiotic_pharmacok2.42260552
13MP0002653_abnormal_ependyma_morphology2.41016139
14MP0003300_gastrointestinal_ulcer2.40576181
15MP0005645_abnormal_hypothalamus_physiol2.40516447
16MP0003646_muscle_fatigue2.36479584
17MP0000685_abnormal_immune_system2.33307606
18MP0006072_abnormal_retinal_apoptosis2.33255734
19MP0005551_abnormal_eye_electrophysiolog2.30087635
20MP0003252_abnormal_bile_duct2.24724585
21MP0009785_altered_susceptibility_to2.21375948
22MP0001873_stomach_inflammation2.18055310
23MP0005083_abnormal_biliary_tract2.17431748
24MP0005646_abnormal_pituitary_gland2.13777795
25MP0003436_decreased_susceptibility_to2.08536738
26MP0002254_reproductive_system_inflammat2.03079527
27MP0004147_increased_porphyrin_level1.99607813
28MP0001968_abnormal_touch/_nociception1.98637130
29MP0005332_abnormal_amino_acid1.96532739
30MP0001790_abnormal_immune_system1.96119879
31MP0005387_immune_system_phenotype1.96119879
32MP0009643_abnormal_urine_homeostasis1.92777616
33MP0003283_abnormal_digestive_organ1.90706020
34MP0005025_abnormal_response_to1.89317641
35MP0002638_abnormal_pupillary_reflex1.87166876
36MP0010234_abnormal_vibrissa_follicle1.86531460
37MP0010155_abnormal_intestine_physiology1.83681040
38MP0005220_abnormal_exocrine_pancreas1.83025521
39MP0005084_abnormal_gallbladder_morpholo1.82685111
40MP0009745_abnormal_behavioral_response1.82562403
41MP0001986_abnormal_taste_sensitivity1.81678997
42MP0009046_muscle_twitch1.81468954
43MP0004019_abnormal_vitamin_homeostasis1.80605944
44MP0001800_abnormal_humoral_immune1.80019972
45MP0005671_abnormal_response_to1.79088940
46MP0004133_heterotaxia1.75837883
47MP0002166_altered_tumor_susceptibility1.73130562
48MP0003011_delayed_dark_adaptation1.72374631
49MP0005253_abnormal_eye_physiology1.70904032
50MP0002736_abnormal_nociception_after1.68298135
51MP0001485_abnormal_pinna_reflex1.67026978
52MP0002148_abnormal_hypersensitivity_rea1.66319218
53MP0003787_abnormal_imprinting1.66247144
54MP0004885_abnormal_endolymph1.65894031
55MP0000372_irregular_coat_pigmentation1.65779124
56MP0004142_abnormal_muscle_tone1.63853082
57MP0002272_abnormal_nervous_system1.63589367
58MP0001845_abnormal_inflammatory_respons1.62365687
59MP0005000_abnormal_immune_tolerance1.62289091
60MP0002876_abnormal_thyroid_physiology1.59233652
61MP0001853_heart_inflammation1.58068662
62MP0003880_abnormal_central_pattern1.57091711
63MP0003195_calcinosis1.57079726
64MP0001529_abnormal_vocalization1.57042666
65MP0002452_abnormal_antigen_presenting1.56373114
66MP0005310_abnormal_salivary_gland1.55747812
67MP0008872_abnormal_physiological_respon1.55566816
68MP0009764_decreased_sensitivity_to1.55422018
69MP0002419_abnormal_innate_immunity1.55196149
70MP0004264_abnormal_extraembryonic_tissu1.55040286
71MP0006292_abnormal_olfactory_placode1.54766459
72MP0002723_abnormal_immune_serum1.53825705
73MP0006276_abnormal_autonomic_nervous1.53188159
74MP0002938_white_spotting1.51392451
75MP0008469_abnormal_protein_level1.48483148
76MP0010329_abnormal_lipoprotein_level1.48372944
77MP0004043_abnormal_pH_regulation1.48246871
78MP0001984_abnormal_olfaction1.48045215
79MP0003866_abnormal_defecation1.47491582
80MP0003868_abnormal_feces_composition1.46560616
81MP0008995_early_reproductive_senescence1.45886520
82MP0002163_abnormal_gland_morphology1.45256225
83MP0003183_abnormal_peptide_metabolism1.44381052
84MP0003191_abnormal_cellular_cholesterol1.42789674
85MP0005636_abnormal_mineral_homeostasis1.42742228
86MP0005379_endocrine/exocrine_gland_phen1.42318720
87MP0006082_CNS_inflammation1.40879867
88MP0002006_tumorigenesis1.39902559
89MP0003186_abnormal_redox_activity1.39359194
90MP0001764_abnormal_homeostasis1.38644987
91MP0001765_abnormal_ion_homeostasis1.38582006
92MP0002160_abnormal_reproductive_system1.37906140
93MP0002136_abnormal_kidney_physiology1.37858053
94MP0002420_abnormal_adaptive_immunity1.37596384
95MP0001819_abnormal_immune_cell1.37213758
96MP0000427_abnormal_hair_cycle1.35809345
97MP0002735_abnormal_chemical_nociception1.35212765
98MP0004947_skin_inflammation1.35087882
99MP0001486_abnormal_startle_reflex1.34702894
100MP0000631_abnormal_neuroendocrine_gland1.34113815
101MP0005389_reproductive_system_phenotype1.34106107
102MP0003763_abnormal_thymus_physiology1.34033184
103MP0001905_abnormal_dopamine_level1.33358820
104MP0002928_abnormal_bile_duct1.33310601
105MP0005319_abnormal_enzyme/_coenzyme1.33265525
106MP0001501_abnormal_sleep_pattern1.32337200
107MP0002572_abnormal_emotion/affect_behav1.32084262
108MP0000609_abnormal_liver_physiology1.31757778
109MP0000569_abnormal_digit_pigmentation1.28211027
110MP0003724_increased_susceptibility_to1.26933561
111MP0005174_abnormal_tail_pigmentation1.26209277
112MP0002733_abnormal_thermal_nociception1.25698617
113MP0001970_abnormal_pain_threshold1.24707795
114MP0005410_abnormal_fertilization1.23023964
115MP0002557_abnormal_social/conspecific_i1.20555817
116MP0001663_abnormal_digestive_system1.19354569
117MP0005058_abnormal_lysosome_morphology1.19123058
118MP0003698_abnormal_male_reproductive1.19006946
119MP0005584_abnormal_enzyme/coenzyme_acti1.18767716
120MP0002405_respiratory_system_inflammati1.18610920
121MP0005464_abnormal_platelet_physiology1.17968023
122MP0008058_abnormal_DNA_repair1.17645342
123MP0002064_seizures1.17094363
124MP0003806_abnormal_nucleotide_metabolis1.15891266
125MP0001929_abnormal_gametogenesis1.14800053
126MP0000490_abnormal_crypts_of1.12913064
127MP0000716_abnormal_immune_system1.12776043
128MP0002095_abnormal_skin_pigmentation1.12061651
129MP0009840_abnormal_foam_cell1.11702393
130MP0002234_abnormal_pharynx_morphology1.11578666
131MP0002396_abnormal_hematopoietic_system1.10621799
132MP0001756_abnormal_urination1.10521160
133MP0003878_abnormal_ear_physiology1.09705245
134MP0005377_hearing/vestibular/ear_phenot1.09705245
135MP0001919_abnormal_reproductive_system1.09624197
136MP0010386_abnormal_urinary_bladder1.09600452
137MP0004742_abnormal_vestibular_system1.08577548
138MP0002398_abnormal_bone_marrow1.05961111
139MP0004782_abnormal_surfactant_physiolog1.05844966
140MP0005075_abnormal_melanosome_morpholog1.05533699
141MP0003122_maternal_imprinting1.04459384
142MP0000689_abnormal_spleen_morphology1.01630126
143MP0003656_abnormal_erythrocyte_physiolo1.01466922
144MP0002277_abnormal_respiratory_mucosa1.00831017
145MP0002118_abnormal_lipid_homeostasis1.00635539
146MP0009333_abnormal_splenocyte_physiolog1.00438095
147MP0000858_altered_metastatic_potential0.99953377
148MP0002067_abnormal_sensory_capabilities0.99285062
149MP0002210_abnormal_sex_determination0.96263354
150MP0004145_abnormal_muscle_electrophysio0.95502855
151MP0002693_abnormal_pancreas_physiology0.94869534
152MP0009763_increased_sensitivity_to0.94755787
153MP0002429_abnormal_blood_cell0.93135580
154MP0006054_spinal_hemorrhage0.92087544
155MP0005451_abnormal_body_composition0.92002999
156MP0003718_maternal_effect0.91061278
157MP0003635_abnormal_synaptic_transmissio0.90290216
158MP0009765_abnormal_xenobiotic_induced0.89825410
159MP0001533_abnormal_skeleton_physiology0.89676075
160MP0000026_abnormal_inner_ear0.89615081
161MP0005195_abnormal_posterior_eye0.88823556
162MP0000538_abnormal_urinary_bladder0.88124749
163MP0009379_abnormal_foot_pigmentation0.86836584
164MP0005167_abnormal_blood-brain_barrier0.86285558
165MP0000230_abnormal_systemic_arterial0.86280159
166MP0002722_abnormal_immune_system0.85912414
167MP0002229_neurodegeneration0.85808670
168MP0005386_behavior/neurological_phenoty0.85571023
169MP0004924_abnormal_behavior0.85571023
170MP0003137_abnormal_impulse_conducting0.85288377
171MP0002132_abnormal_respiratory_system0.85250194
172MP0002063_abnormal_learning/memory/cond0.84604135
173MP0005171_absent_coat_pigmentation0.84457469
174MP0005166_decreased_susceptibility_to0.83293477
175MP0000598_abnormal_liver_morphology0.81997060
176MP0005381_digestive/alimentary_phenotyp0.81898225
177MP0002751_abnormal_autonomic_nervous0.81108428
178MP0001545_abnormal_hematopoietic_system0.81097066
179MP0005397_hematopoietic_system_phenotyp0.81097066
180MP0000465_gastrointestinal_hemorrhage0.81028896
181MP0000653_abnormal_sex_gland0.80515503
182MP0004215_abnormal_myocardial_fiber0.79145572
183MP0005647_abnormal_sex_gland0.79057612
184MP0001944_abnormal_pancreas_morphology0.77083829
185MP0009642_abnormal_blood_homeostasis0.75510534

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.26852512
2Molar tooth sign on MRI (HP:0002419)3.88500587
3Abnormality of midbrain morphology (HP:0002418)3.88500587
4Congenital stationary night blindness (HP:0007642)3.79188203
5Gout (HP:0001997)3.78508213
6Pancreatic fibrosis (HP:0100732)3.73517424
7Type II lissencephaly (HP:0007260)3.72825950
8Nephronophthisis (HP:0000090)3.65608632
9True hermaphroditism (HP:0010459)3.58424437
10Vacuolated lymphocytes (HP:0001922)3.54532808
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50951830
12Abnormality of chloride homeostasis (HP:0011422)3.11712319
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06781424
14Recurrent gram-negative bacterial infections (HP:0005420)3.05716720
15Abnormality of the renal medulla (HP:0100957)3.02264388
16Polydipsia (HP:0001959)2.99282021
17Abnormal drinking behavior (HP:0030082)2.99282021
18Nasal polyposis (HP:0100582)2.97672523
19Acute necrotizing encephalopathy (HP:0006965)2.96235845
20Medial flaring of the eyebrow (HP:0010747)2.94775763
21Mitochondrial inheritance (HP:0001427)2.90997967
22Agammaglobulinemia (HP:0004432)2.90777654
23Abnormality of purine metabolism (HP:0004352)2.89231294
24Inflammation of the large intestine (HP:0002037)2.88624493
25Tubular atrophy (HP:0000092)2.88620483
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88441758
27Hyperactive renin-angiotensin system (HP:0000841)2.82327114
28Fat malabsorption (HP:0002630)2.81914769
29Cerebellar dysplasia (HP:0007033)2.81664508
30Hyperglycinuria (HP:0003108)2.81021415
31Interstitial pulmonary disease (HP:0006530)2.80440370
32Colitis (HP:0002583)2.79888610
33Recurrent bacterial skin infections (HP:0005406)2.79421107
34Eczematoid dermatitis (HP:0000976)2.79038446
35Abnormality of the renal cortex (HP:0011035)2.77073256
36Recurrent bronchitis (HP:0002837)2.76997453
37IgM deficiency (HP:0002850)2.74879438
38Attenuation of retinal blood vessels (HP:0007843)2.73398727
39Abnormality of renal excretion (HP:0011036)2.71714930
40Increased CSF lactate (HP:0002490)2.71594658
41Lipid accumulation in hepatocytes (HP:0006561)2.69230548
42Abnormality of fatty-acid metabolism (HP:0004359)2.68400663
43Recurrent abscess formation (HP:0002722)2.67863563
44Gastrointestinal inflammation (HP:0004386)2.67518934
45Steatorrhea (HP:0002570)2.66851619
46Intrahepatic cholestasis (HP:0001406)2.63654148
47Hyperuricemia (HP:0002149)2.62995071
48Increased purine levels (HP:0004368)2.62995071
49Progressive macrocephaly (HP:0004481)2.62959199
50Acute encephalopathy (HP:0006846)2.62428377
51Increased hepatocellular lipid droplets (HP:0006565)2.62246263
52Abnormality of alanine metabolism (HP:0010916)2.61473921
53Hyperalaninemia (HP:0003348)2.61473921
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61473921
55Proximal tubulopathy (HP:0000114)2.61098869
56Abnormal mitochondria in muscle tissue (HP:0008316)2.59122381
57Chronic hepatic failure (HP:0100626)2.58866608
58Vascular calcification (HP:0004934)2.57717570
59Pustule (HP:0200039)2.57414659
60Recurrent sinusitis (HP:0011108)2.56652911
61Recurrent fungal infections (HP:0002841)2.51239298
62Metabolic alkalosis (HP:0200114)2.50459137
63Reduced antithrombin III activity (HP:0001976)2.50332160
64Abnormality of nucleobase metabolism (HP:0010932)2.50260115
65Recurrent viral infections (HP:0004429)2.47419310
66Congenital, generalized hypertrichosis (HP:0004540)2.45134000
67Abnormality of the intrinsic pathway (HP:0010989)2.44077364
68Renal Fanconi syndrome (HP:0001994)2.43539060
69Abnormality of T cell physiology (HP:0011840)2.42133199
70Abnormality of the nasal mucosa (HP:0000433)2.41737274
71Hypokalemic alkalosis (HP:0001949)2.41736219
72Large for gestational age (HP:0001520)2.40598978
733-Methylglutaconic aciduria (HP:0003535)2.39734587
74Ketosis (HP:0001946)2.38098730
75Thrombocytosis (HP:0001894)2.37778531
76Hypothermia (HP:0002045)2.36738983
77Aplasia/hypoplasia of the uterus (HP:0008684)2.36032866
78Hypoplasia of the pons (HP:0012110)2.35813604
79Abnormality of the common coagulation pathway (HP:0010990)2.35784478
80Alkalosis (HP:0001948)2.34815444
81Complement deficiency (HP:0004431)2.33565038
82Prolonged partial thromboplastin time (HP:0003645)2.33560869
83Abnormal urine output (HP:0012590)2.33136505
84Elevated erythrocyte sedimentation rate (HP:0003565)2.32669919
85Periodontitis (HP:0000704)2.32637974
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.32562809
87Abolished electroretinogram (ERG) (HP:0000550)2.31688284
88Inability to walk (HP:0002540)2.30836563
89Hepatocellular necrosis (HP:0001404)2.30693240
90Hypomagnesemia (HP:0002917)2.29874421
91Abnormality of the pons (HP:0007361)2.29488545
92Abnormal rod and cone electroretinograms (HP:0008323)2.28829821
93Recurrent skin infections (HP:0001581)2.28791831
94Abnormality of sulfur amino acid metabolism (HP:0004339)2.28613404
95Cystic liver disease (HP:0006706)2.28434294
96Conjugated hyperbilirubinemia (HP:0002908)2.28331763
97Generalized aminoaciduria (HP:0002909)2.28128003
98Joint hemorrhage (HP:0005261)2.27104865
99Recurrent cutaneous fungal infections (HP:0011370)2.26902943
100Chronic mucocutaneous candidiasis (HP:0002728)2.26902943
101Onycholysis (HP:0001806)2.26839233
102Autoimmune thrombocytopenia (HP:0001973)2.26808165
103Gait imbalance (HP:0002141)2.26779910
104Congenital primary aphakia (HP:0007707)2.23780257
105Polyuria (HP:0000103)2.23778286
106Hyperammonemia (HP:0001987)2.23534096
107Hepatic necrosis (HP:0002605)2.23099935
108Bronchitis (HP:0012387)2.23091683
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22810611
110Abnormality of glycine metabolism (HP:0010895)2.22726354
111Abnormality of serine family amino acid metabolism (HP:0010894)2.22726354
112Meningitis (HP:0001287)2.22618025
113Hydroxyprolinuria (HP:0003080)2.18792835
114Abnormality of proline metabolism (HP:0010907)2.18792835
115Optic disc pallor (HP:0000543)2.18559137
116Systemic lupus erythematosus (HP:0002725)2.18179398
117Lissencephaly (HP:0001339)2.17680973
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.16612906
119Absent/shortened dynein arms (HP:0200106)2.16612906
120Myositis (HP:0100614)2.15999140
121Cardiovascular calcification (HP:0011915)2.14698940
122Chronic otitis media (HP:0000389)2.14601433
123Abnormality of magnesium homeostasis (HP:0004921)2.12748424
124Deep venous thrombosis (HP:0002625)2.12239352
125Sclerocornea (HP:0000647)2.11805675
126Abnormal biliary tract physiology (HP:0012439)2.11568381
127Bile duct proliferation (HP:0001408)2.11568381
128Decreased central vision (HP:0007663)2.11542906
129Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10866995
130Urinary glycosaminoglycan excretion (HP:0003541)2.09186404
131Mucopolysacchariduria (HP:0008155)2.09186404
132Retinal dysplasia (HP:0007973)2.08696921
133Chronic diarrhea (HP:0002028)2.08221806
134Pancreatitis (HP:0001733)2.07156399
135Nephrogenic diabetes insipidus (HP:0009806)2.06693615
136Pendular nystagmus (HP:0012043)2.06640984
137Hyperglycinemia (HP:0002154)2.04070785
138Severe muscular hypotonia (HP:0006829)2.03668931
139Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03045674
140Xanthomatosis (HP:0000991)2.02109499
141Dysostosis multiplex (HP:0000943)2.00866102
142Increased serum lactate (HP:0002151)1.99138647
143Panhypogammaglobulinemia (HP:0003139)1.98296265
144Micronodular cirrhosis (HP:0001413)1.97827907
145Impaired platelet aggregation (HP:0003540)1.96813600
146Abnormal platelet function (HP:0011869)1.96813600
147Abnormality of B cell number (HP:0010975)1.96681403
148B lymphocytopenia (HP:0010976)1.96681403
149Ketoacidosis (HP:0001993)1.96360437
150Abnormality of polysaccharide metabolism (HP:0011012)1.96133997
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96133997
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96133997
153Abnormality of urine glucose concentration (HP:0011016)1.96106311
154Glycosuria (HP:0003076)1.96106311
155Furrowed tongue (HP:0000221)1.95845567
156Focal motor seizures (HP:0011153)1.95683774
157Decreased circulating renin level (HP:0003351)1.95480661
158Gingival bleeding (HP:0000225)1.95414322
159Hypobetalipoproteinemia (HP:0003563)1.94397527
160Exertional dyspnea (HP:0002875)1.93468583
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.93047859
162Vasculitis (HP:0002633)1.92703232
163Increased circulating renin level (HP:0000848)1.92370079
164Cheilitis (HP:0100825)1.92215953
165Dehydration (HP:0001944)1.92096625
166Male pseudohermaphroditism (HP:0000037)1.90832940
167Optic nerve hypoplasia (HP:0000609)1.88389765
168Progressive inability to walk (HP:0002505)1.88299949
169Occipital encephalocele (HP:0002085)1.86788322
170Congenital hepatic fibrosis (HP:0002612)1.84925565
171Hyperventilation (HP:0002883)1.83773718
172Hemiparesis (HP:0001269)1.83301204
173Gaze-evoked nystagmus (HP:0000640)1.82869879
174Aplasia/Hypoplasia of the uvula (HP:0010293)1.82222509
175Anencephaly (HP:0002323)1.82197222
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.82182575
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81462994
178Concave nail (HP:0001598)1.79688772
179Lactic acidosis (HP:0003128)1.79281390
180Abnormal respiratory epithelium morphology (HP:0012253)1.78738122
181Abnormal respiratory motile cilium morphology (HP:0005938)1.78738122
182Genital tract atresia (HP:0001827)1.78660647
183Abnormality of the labia minora (HP:0012880)1.78358643
184Increased intramyocellular lipid droplets (HP:0012240)1.77890981
185Keratoconus (HP:0000563)1.77630235
186Increased corneal curvature (HP:0100692)1.77630235
187Bony spicule pigmentary retinopathy (HP:0007737)1.75442484
188Renal cortical cysts (HP:0000803)1.75229478
189Abnormality of renal resorption (HP:0011038)1.75156522
190Hypoplasia of the uterus (HP:0000013)1.74442860
191Vaginal atresia (HP:0000148)1.72149295
192Short tibia (HP:0005736)1.70326974
193Absent thumb (HP:0009777)1.70187410
194Methylmalonic acidemia (HP:0002912)1.69947319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.61130528
2ADRBK23.28830273
3MAP3K143.25542414
4BCKDK3.20019065
5BMPR1B3.18613970
6MAP4K23.10387075
7ZAK3.06821494
8MAP4K12.99584824
9TAOK32.88829277
10EPHA22.77414828
11MST42.58441277
12PNCK2.47889841
13FRK2.44213153
14IRAK32.42796712
15TBK12.23561405
16IRAK42.19658514
17TYK22.14209583
18OXSR12.12818357
19FGFR42.02992032
20IKBKE2.02323603
21ZAP701.92626030
22WNK41.78462347
23PINK11.76261626
24TLK11.70028748
25DAPK21.69824971
26JAK31.69369072
27STK391.68814129
28BTK1.68125828
29TEC1.63320388
30NEK91.60680928
31ACVR1B1.55450201
32MAPK131.54034685
33PIM21.45694645
34CASK1.42474485
35TIE11.37121364
36PLK41.35381693
37VRK11.32495963
38MAP3K121.32409498
39TXK1.31225145
40MAP3K41.27594156
41JAK11.27385178
42BLK1.22672629
43CHUK1.20566722
44KIT1.19841365
45IKBKB1.18668558
46PLK21.17709039
47EIF2AK31.15160278
48MKNK21.14242627
49WNK31.12257714
50STK101.12100578
51PIK3CG1.12031356
52MAP2K61.10902285
53PDK31.10380936
54PDK41.10380936
55TESK11.09922199
56LRRK21.09448230
57PRKG21.08179847
58TNIK1.07880170
59PTK61.05798632
60MST1R1.05731253
61PRKCG1.03877512
62ADRBK11.03640046
63TRIM281.02108441
64PDK21.02051945
65CSF1R1.00556639
66MAP2K31.00430142
67LMTK20.99061213
68MAP2K20.98607399
69MAP3K130.98412125
70FGFR20.98013072
71RIPK10.97949983
72TGFBR10.97899239
73EPHB10.97737005
74SYK0.97153817
75PHKG10.97042129
76PHKG20.97042129
77CSK0.96352087
78DYRK20.95019159
79PRKCE0.93394566
80STK160.91093385
81ITK0.90650945
82MAP3K30.89245610
83RPS6KA40.87851087
84ERBB30.83950211
85PAK30.83747551
86IRAK10.83605197
87GRK60.83573230
88TSSK60.83089091
89MAPK110.82554972
90NLK0.80858399
91FLT30.79961308
92KDR0.79873009
93NUAK10.79826239
94RPS6KA50.79758113
95CSNK1G10.79114314
96PLK30.78918630
97GRK70.78684273
98CSNK1G20.78669153
99VRK20.78462813
100SIK30.77842886
101MYLK0.76966019
102SIK10.76504463
103DYRK1B0.76318253
104LIMK10.75956262
105STK38L0.75533330
106JAK20.74215189
107FGFR30.73408851
108MARK10.73090729
109CSNK1G30.70521084
110PIK3CA0.70335927
111MUSK0.69332592
112NTRK30.69306010
113RPS6KB20.68750579
114OBSCN0.68716840
115TGFBR20.67842789
116PIM10.66818984
117PKN10.66459653
118NME20.64915745
119WEE10.63963255
120MAP2K70.63141780
121LYN0.62732140
122DYRK30.61864940
123RIPK40.59265146
124CDK80.57953641
125AKT30.57477839
126CAMK2A0.57393474
127MAPK150.56804781
128MAPKAPK30.54636937
129MKNK10.54574117
130LCK0.54385522
131GRK10.54113642
132PRKCQ0.51934588
133NTRK20.51407066
134PRKCI0.49923642
135PRKACA0.49674948
136MATK0.49139797
137INSRR0.48979241
138BMPR20.47423254
139EEF2K0.47019864
140EPHA40.46602694
141LATS10.45131521
142CAMKK20.43901268
143TNK20.40938179
144PRKCD0.40872027
145PTK2B0.40828352
146PLK10.40315471
147CSNK1A10.39546912
148PRKCA0.39464813
149SGK30.39103509
150MAP3K100.38069141
151CAMK10.37811644
152CSNK1A1L0.37479802
153NME10.37264035
154MAP3K70.36724050
155PASK0.36604935
156MAPKAPK50.36203114
157MINK10.35531633
158CAMK1G0.34594371
159ABL10.34364454
160CDK30.34301074
161DYRK1A0.33731831
162SGK20.33502120
163STK30.33454859
164PRKG10.33420688
165EPHA30.33156539
166PTK20.33026139
167PAK40.31883276
168ERBB40.28721506
169HCK0.25798575

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.11738493
2Phototransduction_Homo sapiens_hsa047442.94825934
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62817284
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56605759
5Parkinsons disease_Homo sapiens_hsa050122.47602542
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37590606
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32401825
8Linoleic acid metabolism_Homo sapiens_hsa005912.30787065
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.27147219
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19594013
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15941892
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.00345971
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97687712
14Fatty acid degradation_Homo sapiens_hsa000711.87869768
15Folate biosynthesis_Homo sapiens_hsa007901.86347314
16Tryptophan metabolism_Homo sapiens_hsa003801.85664268
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85020724
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.84907301
19Sulfur metabolism_Homo sapiens_hsa009201.83605138
20Peroxisome_Homo sapiens_hsa041461.83200646
21Vitamin digestion and absorption_Homo sapiens_hsa049771.76510322
22Primary immunodeficiency_Homo sapiens_hsa053401.75651332
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.73924088
24RNA polymerase_Homo sapiens_hsa030201.72680210
25Propanoate metabolism_Homo sapiens_hsa006401.72649798
26Other glycan degradation_Homo sapiens_hsa005111.67886230
27Protein export_Homo sapiens_hsa030601.67163418
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66861160
29Ether lipid metabolism_Homo sapiens_hsa005651.65817864
30Pentose phosphate pathway_Homo sapiens_hsa000301.62615723
31Basal transcription factors_Homo sapiens_hsa030221.60506089
32Nicotine addiction_Homo sapiens_hsa050331.59716464
33Huntingtons disease_Homo sapiens_hsa050161.58828447
34Ribosome_Homo sapiens_hsa030101.57807117
35Cardiac muscle contraction_Homo sapiens_hsa042601.57739725
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56543535
37Alzheimers disease_Homo sapiens_hsa050101.55243531
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54266183
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53295824
40Homologous recombination_Homo sapiens_hsa034401.52783045
41Selenocompound metabolism_Homo sapiens_hsa004501.51481600
42Fanconi anemia pathway_Homo sapiens_hsa034601.46352261
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46336390
44Chemical carcinogenesis_Homo sapiens_hsa052041.44255141
45Pyruvate metabolism_Homo sapiens_hsa006201.43489650
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42708105
47Caffeine metabolism_Homo sapiens_hsa002321.41803382
48Glutathione metabolism_Homo sapiens_hsa004801.41358191
49Complement and coagulation cascades_Homo sapiens_hsa046101.40342787
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39633553
51Fat digestion and absorption_Homo sapiens_hsa049751.38785020
52Arginine biosynthesis_Homo sapiens_hsa002201.37262436
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34174888
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.32961677
55Olfactory transduction_Homo sapiens_hsa047401.32116226
56Staphylococcus aureus infection_Homo sapiens_hsa051501.30953228
57Proteasome_Homo sapiens_hsa030501.30042493
58Histidine metabolism_Homo sapiens_hsa003401.28973506
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28053302
60Nitrogen metabolism_Homo sapiens_hsa009101.27468388
61beta-Alanine metabolism_Homo sapiens_hsa004101.26795032
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25726746
63PPAR signaling pathway_Homo sapiens_hsa033201.23714655
64Taste transduction_Homo sapiens_hsa047421.22945682
65Drug metabolism - other enzymes_Homo sapiens_hsa009831.22740262
66Leishmaniasis_Homo sapiens_hsa051401.21583291
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21083597
68Antigen processing and presentation_Homo sapiens_hsa046121.19320083
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18081996
70Hematopoietic cell lineage_Homo sapiens_hsa046401.17295317
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16479250
72Starch and sucrose metabolism_Homo sapiens_hsa005001.16316393
73Fructose and mannose metabolism_Homo sapiens_hsa000511.15772359
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15711377
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14679685
76RNA degradation_Homo sapiens_hsa030181.14243911
77Pancreatic secretion_Homo sapiens_hsa049721.11918508
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11760750
79Cysteine and methionine metabolism_Homo sapiens_hsa002701.10138798
80ABC transporters_Homo sapiens_hsa020101.08809916
81Fatty acid metabolism_Homo sapiens_hsa012121.08051807
82One carbon pool by folate_Homo sapiens_hsa006701.05984276
83Insulin secretion_Homo sapiens_hsa049111.03610135
84Protein digestion and absorption_Homo sapiens_hsa049741.02698052
85Arachidonic acid metabolism_Homo sapiens_hsa005901.02182937
86Legionellosis_Homo sapiens_hsa051341.01708826
87Morphine addiction_Homo sapiens_hsa050320.99175653
88Collecting duct acid secretion_Homo sapiens_hsa049660.98839158
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95853371
90Glycerolipid metabolism_Homo sapiens_hsa005610.94926192
91Measles_Homo sapiens_hsa051620.94545693
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.92412999
93Carbon metabolism_Homo sapiens_hsa012000.91861914
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.91767750
95Regulation of autophagy_Homo sapiens_hsa041400.91703358
96Bile secretion_Homo sapiens_hsa049760.89160720
97Purine metabolism_Homo sapiens_hsa002300.87038218
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86808870
99Type I diabetes mellitus_Homo sapiens_hsa049400.86312052
100Influenza A_Homo sapiens_hsa051640.85531292
101Retinol metabolism_Homo sapiens_hsa008300.85344738
102Renin-angiotensin system_Homo sapiens_hsa046140.84906395
103Steroid biosynthesis_Homo sapiens_hsa001000.84474297
104Asthma_Homo sapiens_hsa053100.83618231
105N-Glycan biosynthesis_Homo sapiens_hsa005100.81435603
106Hepatitis C_Homo sapiens_hsa051600.80360003
107Fatty acid elongation_Homo sapiens_hsa000620.79769272
108Sulfur relay system_Homo sapiens_hsa041220.78293112
109GABAergic synapse_Homo sapiens_hsa047270.78264813
110B cell receptor signaling pathway_Homo sapiens_hsa046620.77546936
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77340086
112Butanoate metabolism_Homo sapiens_hsa006500.76345228
113Serotonergic synapse_Homo sapiens_hsa047260.74634365
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74115592
115Ovarian steroidogenesis_Homo sapiens_hsa049130.73420345
116Biosynthesis of amino acids_Homo sapiens_hsa012300.73115218
117Osteoclast differentiation_Homo sapiens_hsa043800.70839819
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70712772
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.69843156
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68341025
121Arginine and proline metabolism_Homo sapiens_hsa003300.68311360
122Fatty acid biosynthesis_Homo sapiens_hsa000610.67045853
123Lysosome_Homo sapiens_hsa041420.66637459
124Pertussis_Homo sapiens_hsa051330.66246457
125Pyrimidine metabolism_Homo sapiens_hsa002400.65264169
126Circadian entrainment_Homo sapiens_hsa047130.63979608
127Phenylalanine metabolism_Homo sapiens_hsa003600.63552498
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63534735
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63232233
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62286650
131Herpes simplex infection_Homo sapiens_hsa051680.61250630
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59029075
133Toxoplasmosis_Homo sapiens_hsa051450.58496935
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57020863
135Glutamatergic synapse_Homo sapiens_hsa047240.55754607
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55725605
137TNF signaling pathway_Homo sapiens_hsa046680.55484376
138African trypanosomiasis_Homo sapiens_hsa051430.55419804
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54883718
140Allograft rejection_Homo sapiens_hsa053300.54882531
141Graft-versus-host disease_Homo sapiens_hsa053320.53420922
142Tuberculosis_Homo sapiens_hsa051520.49745006
143Mineral absorption_Homo sapiens_hsa049780.48918952
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47630667
145Salivary secretion_Homo sapiens_hsa049700.45619801
146Metabolic pathways_Homo sapiens_hsa011000.44118013
147Calcium signaling pathway_Homo sapiens_hsa040200.42997476
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41188188
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38978476
150Sphingolipid metabolism_Homo sapiens_hsa006000.37690134
151Autoimmune thyroid disease_Homo sapiens_hsa053200.31540578
152Amphetamine addiction_Homo sapiens_hsa050310.29309796

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