CNBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.44817336
2ribosomal small subunit assembly (GO:0000028)5.01398942
3nucleobase biosynthetic process (GO:0046112)4.89752124
4DNA strand elongation involved in DNA replication (GO:0006271)4.89678937
5purine nucleobase biosynthetic process (GO:0009113)4.80409789
6telomere maintenance via semi-conservative replication (GO:0032201)4.74099400
7DNA strand elongation (GO:0022616)4.68515941
8maturation of SSU-rRNA (GO:0030490)4.68151707
9formation of translation preinitiation complex (GO:0001731)4.47680643
10DNA replication initiation (GO:0006270)4.44470445
11telomere maintenance via recombination (GO:0000722)4.19994099
12proteasome assembly (GO:0043248)4.10510329
13DNA unwinding involved in DNA replication (GO:0006268)4.08722492
14ribosome biogenesis (GO:0042254)4.06924096
15IMP biosynthetic process (GO:0006188)4.03322049
16DNA replication checkpoint (GO:0000076)3.92534357
17ribonucleoprotein complex biogenesis (GO:0022613)3.92128318
18mitotic recombination (GO:0006312)3.89662928
19ribosomal large subunit biogenesis (GO:0042273)3.89480639
20ribosome assembly (GO:0042255)3.88797645
21CENP-A containing nucleosome assembly (GO:0034080)3.85876072
22pseudouridine synthesis (GO:0001522)3.83252404
23telomere maintenance via telomere lengthening (GO:0010833)3.81773617
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78109852
25ribosomal small subunit biogenesis (GO:0042274)3.73975327
26translational termination (GO:0006415)3.72909451
27viral transcription (GO:0019083)3.72831915
28chromatin remodeling at centromere (GO:0031055)3.70363230
29rRNA processing (GO:0006364)3.67177067
30establishment of viral latency (GO:0019043)3.66709255
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.65196415
32IMP metabolic process (GO:0046040)3.64385360
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.63495835
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62238862
35DNA double-strand break processing (GO:0000729)3.61817034
36oxidative phosphorylation (GO:0006119)3.61084446
37DNA ligation (GO:0006266)3.58944768
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57551464
39rRNA modification (GO:0000154)3.56367985
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.53808385
41rRNA metabolic process (GO:0016072)3.52978080
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51840784
43translational elongation (GO:0006414)3.51407870
44mitotic metaphase plate congression (GO:0007080)3.49608998
45translational initiation (GO:0006413)3.49259035
46spliceosomal snRNP assembly (GO:0000387)3.46043818
47DNA replication-independent nucleosome organization (GO:0034724)3.45733644
48DNA replication-independent nucleosome assembly (GO:0006336)3.45733644
49negative regulation of ligase activity (GO:0051352)3.43366926
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43366926
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41407590
52DNA catabolic process, exonucleolytic (GO:0000738)3.37025560
53transcription-coupled nucleotide-excision repair (GO:0006283)3.34335543
54cotranslational protein targeting to membrane (GO:0006613)3.33451859
55cullin deneddylation (GO:0010388)3.32995324
56regulation of ubiquitin-protein transferase activity (GO:0051438)3.31900518
57protein targeting to ER (GO:0045047)3.30169993
58viral mRNA export from host cell nucleus (GO:0046784)3.29534496
59G1/S transition of mitotic cell cycle (GO:0000082)3.28055542
60cell cycle G1/S phase transition (GO:0044843)3.28055542
61protein deneddylation (GO:0000338)3.25899970
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23296127
63termination of RNA polymerase III transcription (GO:0006386)3.23033679
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.23033679
65regulation of ligase activity (GO:0051340)3.22337530
66cellular component biogenesis (GO:0044085)3.22085984
67DNA replication-dependent nucleosome assembly (GO:0006335)3.21496276
68DNA replication-dependent nucleosome organization (GO:0034723)3.21496276
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21440452
70maturation of 5.8S rRNA (GO:0000460)3.20138976
71regulation of mitotic spindle checkpoint (GO:1903504)3.20057094
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20057094
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19301159
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19301159
75double-strand break repair via nonhomologous end joining (GO:0006303)3.19162161
76non-recombinational repair (GO:0000726)3.19162161
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19042908
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19042908
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19042908
80protein localization to endoplasmic reticulum (GO:0070972)3.16802004
81mitotic nuclear envelope disassembly (GO:0007077)3.16186153
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15961014
83regulation of cellular amino acid metabolic process (GO:0006521)3.15892983
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14332521
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14028356
86metaphase plate congression (GO:0051310)3.13635290
877-methylguanosine mRNA capping (GO:0006370)3.12950870
88signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12883475
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.12883475
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11760965
91chaperone-mediated protein transport (GO:0072321)3.10101167
92mitochondrial RNA metabolic process (GO:0000959)3.09327158
93RNA capping (GO:0036260)3.08477497
947-methylguanosine RNA capping (GO:0009452)3.08477497
95translation (GO:0006412)3.08475212
96tRNA aminoacylation for protein translation (GO:0006418)3.08122007
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.07666368
98histone exchange (GO:0043486)3.05925247
99ATP synthesis coupled proton transport (GO:0015986)3.05683175
100energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05683175
101transcription from mitochondrial promoter (GO:0006390)3.05294587
102deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05092181
103tRNA aminoacylation (GO:0043039)3.04762811
104amino acid activation (GO:0043038)3.04762811
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04157631
106positive regulation of ligase activity (GO:0051351)3.03858937
107folic acid-containing compound biosynthetic process (GO:0009396)3.03685448
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03448291
109protein targeting to mitochondrion (GO:0006626)3.02267361
110purine nucleotide salvage (GO:0032261)3.01890446
111establishment of protein localization to mitochondrial membrane (GO:0090151)3.01446770
112rRNA methylation (GO:0031167)3.01334753
113termination of RNA polymerase I transcription (GO:0006363)3.01106916
114somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.00584463
115isotype switching (GO:0045190)3.00584463
116somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.00584463
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00326029
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00326029
119establishment of integrated proviral latency (GO:0075713)2.99809559
120kinetochore organization (GO:0051383)2.98131248
121protein localization to kinetochore (GO:0034501)2.98085955
122telomere organization (GO:0032200)2.94994113
123telomere maintenance (GO:0000723)2.94714506
124viral life cycle (GO:0019058)2.94708839
125cellular protein complex disassembly (GO:0043624)2.94694366
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93773743
127ncRNA processing (GO:0034470)2.93300689
128regulation of mitochondrial translation (GO:0070129)2.93195960
129negative regulation of protein ubiquitination (GO:0031397)2.90820516
130respiratory chain complex IV assembly (GO:0008535)2.90477341
131DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89385723
132tricarboxylic acid cycle (GO:0006099)2.86113348
133antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85543934
134histone mRNA metabolic process (GO:0008334)2.83393429
135branched-chain amino acid catabolic process (GO:0009083)2.82807923
136DNA damage response, detection of DNA damage (GO:0042769)2.80528175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.50891950
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.55741660
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00764985
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61916230
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.44714528
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.38610241
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32059154
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25150757
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.12511223
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03783744
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93790706
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90647602
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87650519
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78925650
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74143695
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67490984
17VDR_23849224_ChIP-Seq_CD4+_Human2.59506537
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57485408
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.54039961
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44942585
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37353522
22* XRN2_22483619_ChIP-Seq_HELA_Human2.35935996
23* FOXP3_21729870_ChIP-Seq_TREG_Human2.22388916
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21195996
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18818355
26DCP1A_22483619_ChIP-Seq_HELA_Human2.16886772
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10940915
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09550078
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08962805
30GABP_19822575_ChIP-Seq_HepG2_Human2.08432239
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02998210
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98824336
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98681209
34AR_21909140_ChIP-Seq_LNCAP_Human1.97547550
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95359953
36TTF2_22483619_ChIP-Seq_HELA_Human1.93649873
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92060503
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89645732
39ELK1_19687146_ChIP-ChIP_HELA_Human1.88539243
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.84814991
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83959211
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80357669
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77356732
44* E2F1_21310950_ChIP-Seq_MCF-7_Human1.74956369
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72341616
46CIITA_25753668_ChIP-Seq_RAJI_Human1.71822721
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70650183
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.68681171
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.67765726
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66974884
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63560383
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.62355004
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60419425
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55589848
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54375697
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51877701
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46983039
58KDM5A_27292631_Chip-Seq_BREAST_Human1.41150267
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40046893
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.39534055
61* MYC_22102868_ChIP-Seq_BL_Human1.32586910
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30761179
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29004668
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27302506
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25681089
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23816320
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19084153
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16804423
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14353449
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13902191
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.13241207
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.12012787
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11415751
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10120830
75TFEB_21752829_ChIP-Seq_HELA_Human1.10117089
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09254084
77* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08906713
78SPI1_23547873_ChIP-Seq_NB4_Human1.07554343
79MYC_18940864_ChIP-ChIP_HL60_Human1.04612785
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02235820
81* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01947647
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00483598
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97713149
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97282996
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94265356
86IGF1R_20145208_ChIP-Seq_DFB_Human0.92808980
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92179966
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92116623
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91606926
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91033683
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89803025
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.89524291
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88770548
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88397285
95* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87964049
96EWS_26573619_Chip-Seq_HEK293_Human0.87416158
97ZNF274_21170338_ChIP-Seq_K562_Hela0.87063904
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85770996
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.85071083
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84759077
101IRF1_19129219_ChIP-ChIP_H3396_Human0.84202510
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82563216
103* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82550774
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.81435589
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80206069
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79337864
107MYB_26560356_Chip-Seq_TH2_Human0.79213113
108* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77672517
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75683726
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.75585847
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75436308
112VDR_21846776_ChIP-Seq_THP-1_Human0.74343657
113ELF5_23300383_ChIP-Seq_T47D_Human0.71552022
114VDR_22108803_ChIP-Seq_LS180_Human0.69918816
115GATA1_22025678_ChIP-Seq_K562_Human0.69556468
116SCL_19346495_ChIP-Seq_HPC-7_Human0.69222387
117FUS_26573619_Chip-Seq_HEK293_Human0.67912994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41167552
2MP0010094_abnormal_chromosome_stability4.61401442
3MP0004957_abnormal_blastocyst_morpholog4.43381905
4MP0003111_abnormal_nucleus_morphology3.94221388
5MP0008057_abnormal_DNA_replication3.93053930
6MP0008058_abnormal_DNA_repair3.78560746
7MP0003077_abnormal_cell_cycle3.76158032
8MP0002396_abnormal_hematopoietic_system3.58034763
9MP0008007_abnormal_cellular_replicative3.33120927
10MP0008932_abnormal_embryonic_tissue2.55765023
11MP0003786_premature_aging2.49508809
12MP0003123_paternal_imprinting2.25993574
13MP0008877_abnormal_DNA_methylation2.24621049
14MP0004808_abnormal_hematopoietic_stem2.06874950
15MP0003763_abnormal_thymus_physiology1.99331523
16MP0000490_abnormal_crypts_of1.94657343
17MP0001730_embryonic_growth_arrest1.94206437
18MP0000350_abnormal_cell_proliferation1.91163227
19MP0006072_abnormal_retinal_apoptosis1.84910077
20MP0003646_muscle_fatigue1.80400966
21MP0009333_abnormal_splenocyte_physiolog1.65109252
22MP0003806_abnormal_nucleotide_metabolis1.63290299
23MP0004145_abnormal_muscle_electrophysio1.58812275
24MP0005397_hematopoietic_system_phenotyp1.57416604
25MP0001545_abnormal_hematopoietic_system1.57416604
26MP0003718_maternal_effect1.55289184
27MP0006054_spinal_hemorrhage1.55080208
28MP0002019_abnormal_tumor_incidence1.50997050
29MP0010352_gastrointestinal_tract_polyps1.49359963
30* MP0000313_abnormal_cell_death1.42731549
31MP0002398_abnormal_bone_marrow1.41770148
32* MP0002080_prenatal_lethality1.40824642
33* MP0001697_abnormal_embryo_size1.39033144
34MP0002837_dystrophic_cardiac_calcinosis1.38855343
35MP0000749_muscle_degeneration1.38383411
36MP0001853_heart_inflammation1.38185304
37MP0004215_abnormal_myocardial_fiber1.37148875
38MP0003567_abnormal_fetal_cardiomyocyte1.36526305
39MP0003186_abnormal_redox_activity1.35079279
40MP0010307_abnormal_tumor_latency1.33921039
41MP0004147_increased_porphyrin_level1.33893554
42MP0002722_abnormal_immune_system1.31432376
43MP0000703_abnormal_thymus_morphology1.30568589
44MP0000689_abnormal_spleen_morphology1.30288300
45MP0002269_muscular_atrophy1.27656313
46MP0005330_cardiomyopathy1.27442012
47MP0005671_abnormal_response_to1.27375102
48* MP0001672_abnormal_embryogenesis/_devel1.26820493
49* MP0005380_embryogenesis_phenotype1.26820493
50MP0008789_abnormal_olfactory_epithelium1.26047488
51MP0005075_abnormal_melanosome_morpholog1.25761709
52MP0006036_abnormal_mitochondrial_physio1.24769141
53MP0002132_abnormal_respiratory_system1.24294295
54MP0002102_abnormal_ear_morphology1.23938225
55MP0003984_embryonic_growth_retardation1.23414365
56MP0000465_gastrointestinal_hemorrhage1.23039127
57MP0009697_abnormal_copulation1.21345893
58MP0002088_abnormal_embryonic_growth/wei1.19188155
59MP0002429_abnormal_blood_cell1.12388805
60MP0002210_abnormal_sex_determination1.11996202
61MP0003315_abnormal_perineum_morphology1.10142755
62MP0004782_abnormal_surfactant_physiolog1.09218798
63MP0001529_abnormal_vocalization1.07130225
64MP0000358_abnormal_cell_content/1.06345079
65MP0000751_myopathy1.03281136
66MP0005408_hypopigmentation1.03140878
67MP0001145_abnormal_male_reproductive1.01790544
68MP0006292_abnormal_olfactory_placode1.01782618
69MP0005253_abnormal_eye_physiology1.00769034
70MP0000716_abnormal_immune_system1.00624234
71MP0002086_abnormal_extraembryonic_tissu1.00234423
72MP0001835_abnormal_antigen_presentation0.99521385
73MP0002095_abnormal_skin_pigmentation0.98496881
74* MP0002085_abnormal_embryonic_tissue0.97789689
75MP0002009_preneoplasia0.96205094
76MP0002160_abnormal_reproductive_system0.96144802
77MP0002938_white_spotting0.95903358
78MP0009379_abnormal_foot_pigmentation0.94744809
79MP0003011_delayed_dark_adaptation0.94006365
80MP0004197_abnormal_fetal_growth/weight/0.93985212
81MP0003121_genomic_imprinting0.93386844
82MP0006035_abnormal_mitochondrial_morpho0.93042442
83MP0000747_muscle_weakness0.91568549
84MP0003221_abnormal_cardiomyocyte_apopto0.89487349
85MP0000685_abnormal_immune_system0.88914638
86MP0005389_reproductive_system_phenotype0.87664016
87MP0000653_abnormal_sex_gland0.87325366
88MP0001929_abnormal_gametogenesis0.85605888
89* MP0002084_abnormal_developmental_patter0.85427993
90MP0002166_altered_tumor_susceptibility0.82214894
91MP0002420_abnormal_adaptive_immunity0.81035071
92MP0004036_abnormal_muscle_relaxation0.80531860
93MP0003941_abnormal_skin_development0.78682359
94MP0001119_abnormal_female_reproductive0.78453487
95MP0001819_abnormal_immune_cell0.78246215
96MP0003943_abnormal_hepatobiliary_system0.77278527
97MP0008875_abnormal_xenobiotic_pharmacok0.76287337
98MP0010030_abnormal_orbit_morphology0.76101531
99MP0001764_abnormal_homeostasis0.75359919
100MP0001727_abnormal_embryo_implantation0.74049375
101MP0008260_abnormal_autophagy0.73778412
102MP0005384_cellular_phenotype0.73675396
103MP0001800_abnormal_humoral_immune0.73633943
104MP0004084_abnormal_cardiac_muscle0.73030409
105MP0002106_abnormal_muscle_physiology0.72627803
106MP0001873_stomach_inflammation0.71342349
107MP0003866_abnormal_defecation0.70849495
108MP0008995_early_reproductive_senescence0.70624193
109MP0001661_extended_life_span0.70262147
110MP0001919_abnormal_reproductive_system0.68185859
111MP0009785_altered_susceptibility_to0.67399237
112MP0002006_tumorigenesis0.66941243
113MP0002723_abnormal_immune_serum0.66313357
114MP0000858_altered_metastatic_potential0.65335932
115MP0002452_abnormal_antigen_presenting0.65209647
116MP0005084_abnormal_gallbladder_morpholo0.64986404
117MP0001984_abnormal_olfaction0.64700436
118MP0002148_abnormal_hypersensitivity_rea0.64646043
119MP0000477_abnormal_intestine_morphology0.63967799
120MP0005319_abnormal_enzyme/_coenzyme0.62753504
121MP0008873_increased_physiological_sensi0.62656858
122MP0005621_abnormal_cell_physiology0.62477550
123MP0009672_abnormal_birth_weight0.62390623
124MP0005394_taste/olfaction_phenotype0.61254006
125MP0005499_abnormal_olfactory_system0.61254006
126MP0002405_respiratory_system_inflammati0.60900586
127MP0005636_abnormal_mineral_homeostasis0.60801228
128MP0003137_abnormal_impulse_conducting0.59166582
129MP0002234_abnormal_pharynx_morphology0.58919749
130MP0010155_abnormal_intestine_physiology0.57583755
131* MP0001293_anophthalmia0.57485460
132MP0005220_abnormal_exocrine_pancreas0.55413930
133MP0000372_irregular_coat_pigmentation0.55359046
134MP0005266_abnormal_metabolism0.55300383
135MP0001542_abnormal_bone_strength0.54646498
136MP0002111_abnormal_tail_morphology0.53056456
137MP0003656_abnormal_erythrocyte_physiolo0.50064454

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.38042294
2Aplastic anemia (HP:0001915)4.91322965
3Abnormal number of erythroid precursors (HP:0012131)4.48885557
4Abnormality of cells of the erythroid lineage (HP:0012130)4.48126680
5Oral leukoplakia (HP:0002745)4.39981408
6Reticulocytopenia (HP:0001896)4.03559485
7Increased intramyocellular lipid droplets (HP:0012240)3.83792098
8Acute necrotizing encephalopathy (HP:0006965)3.78790572
9Acute encephalopathy (HP:0006846)3.60337428
10Breast hypoplasia (HP:0003187)3.56861348
11Exercise-induced muscle cramps (HP:0003710)3.51028938
12Rough bone trabeculation (HP:0100670)3.46179531
13Nemaline bodies (HP:0003798)3.38662583
14Colon cancer (HP:0003003)3.38554354
15Increased muscle lipid content (HP:0009058)3.22567493
16Progressive macrocephaly (HP:0004481)3.18317758
17Lipid accumulation in hepatocytes (HP:0006561)3.15234541
18Abnormality of the anterior horn cell (HP:0006802)3.11232072
19Degeneration of anterior horn cells (HP:0002398)3.11232072
20B lymphocytopenia (HP:0010976)3.11178834
21Microretrognathia (HP:0000308)3.07223388
22Muscle fiber inclusion bodies (HP:0100299)3.05878202
2311 pairs of ribs (HP:0000878)3.03573397
24Cerebral hypomyelination (HP:0006808)3.03013108
25Macrocytic anemia (HP:0001972)3.01123209
26Cerebral edema (HP:0002181)2.99190667
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.98847082
28Thrombocytosis (HP:0001894)2.98391125
29Type I transferrin isoform profile (HP:0003642)2.89937346
30Carpal bone hypoplasia (HP:0001498)2.86269864
31Premature graying of hair (HP:0002216)2.81861982
32Abnormality of B cell number (HP:0010975)2.81457134
33Selective tooth agenesis (HP:0001592)2.80001261
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79357857
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79357857
36Rhabdomyolysis (HP:0003201)2.74705880
37Pancytopenia (HP:0001876)2.71940121
38Pallor (HP:0000980)2.70190401
39Irregular epiphyses (HP:0010582)2.68201236
40Increased serum lactate (HP:0002151)2.66852080
41Hyperalaninemia (HP:0003348)2.66754520
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66754520
43Abnormality of alanine metabolism (HP:0010916)2.66754520
44Patellar aplasia (HP:0006443)2.63444375
45Hepatocellular necrosis (HP:0001404)2.62250174
46Methylmalonic acidemia (HP:0002912)2.61449357
47Myoglobinuria (HP:0002913)2.61433439
48Aplasia/Hypoplasia of the patella (HP:0006498)2.52271252
49Abnormality of methionine metabolism (HP:0010901)2.52224047
50Myelodysplasia (HP:0002863)2.52214554
51Severe combined immunodeficiency (HP:0004430)2.50935321
52Ragged-red muscle fibers (HP:0003200)2.47844277
53Abnormality of the preputium (HP:0100587)2.47785042
54Combined immunodeficiency (HP:0005387)2.46119014
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44824532
56Abnormality of serum amino acid levels (HP:0003112)2.43824582
57Hepatic necrosis (HP:0002605)2.42707437
58Abnormal trabecular bone morphology (HP:0100671)2.42271317
59Respiratory failure (HP:0002878)2.38885732
60Hyperglycinemia (HP:0002154)2.37291808
61Methylmalonic aciduria (HP:0012120)2.36913648
62Increased CSF lactate (HP:0002490)2.34640621
63Chromsome breakage (HP:0040012)2.33951195
64Neoplasm of the pancreas (HP:0002894)2.33913923
65Lymphoma (HP:0002665)2.29738807
66Absent thumb (HP:0009777)2.29715649
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.28480655
68Abnormality of chromosome stability (HP:0003220)2.28067171
69Sparse eyelashes (HP:0000653)2.27832626
70Bone marrow hypocellularity (HP:0005528)2.27501784
71Abnormality of glycine metabolism (HP:0010895)2.26896092
72Abnormality of serine family amino acid metabolism (HP:0010894)2.26896092
73Medulloblastoma (HP:0002885)2.26419842
74Hyperglycinuria (HP:0003108)2.25001085
75Abnormal protein glycosylation (HP:0012346)2.24964888
76Abnormal glycosylation (HP:0012345)2.24964888
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24964888
78Abnormal protein N-linked glycosylation (HP:0012347)2.24964888
793-Methylglutaconic aciduria (HP:0003535)2.21580212
80Cellular immunodeficiency (HP:0005374)2.20578710
81Reduced antithrombin III activity (HP:0001976)2.20067789
82Progressive muscle weakness (HP:0003323)2.19471764
83Renal Fanconi syndrome (HP:0001994)2.19326202
84Neoplasm of the adrenal gland (HP:0100631)2.18492554
85Agnosia (HP:0010524)2.18049133
86Meckel diverticulum (HP:0002245)2.17885751
87Secondary amenorrhea (HP:0000869)2.17003248
88Increased serum pyruvate (HP:0003542)2.16200062
89Abnormality of glycolysis (HP:0004366)2.16200062
90Trismus (HP:0000211)2.16172431
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15852242
92Dicarboxylic aciduria (HP:0003215)2.15852242
93Mitochondrial inheritance (HP:0001427)2.15436127
94Abnormality of the ileum (HP:0001549)2.14207972
95Megaloblastic anemia (HP:0001889)2.13837904
96Lethargy (HP:0001254)2.12945084
97Microvesicular hepatic steatosis (HP:0001414)2.12909259
98Entropion (HP:0000621)2.12654819
99Glossoptosis (HP:0000162)2.12373243
100Respiratory difficulties (HP:0002880)2.07317398
101Slender long bone (HP:0003100)2.07011523
102Abnormality of the labia minora (HP:0012880)2.06630671
103Increased hepatocellular lipid droplets (HP:0006565)2.05113608
104CNS hypomyelination (HP:0003429)2.04784669
105Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04472083
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03494631
107CNS demyelination (HP:0007305)2.03185463
108* IgG deficiency (HP:0004315)2.02440838
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01777500
110Aplasia/Hypoplasia of the uvula (HP:0010293)2.01662558
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99525013
112Leukodystrophy (HP:0002415)1.97008002
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.96325343
114Calcaneovalgus deformity (HP:0001848)1.94652482
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94121351
116Postnatal microcephaly (HP:0005484)1.92471491
117Petechiae (HP:0000967)1.92072116
118Amaurosis fugax (HP:0100576)1.91275184
119Lactic acidosis (HP:0003128)1.91040191
120Premature ovarian failure (HP:0008209)1.88634690
121Basal cell carcinoma (HP:0002671)1.87522812
122Sloping forehead (HP:0000340)1.87411467
123Small intestinal stenosis (HP:0012848)1.86226819
124Duodenal stenosis (HP:0100867)1.86226819
125Optic disc pallor (HP:0000543)1.85746256
126Exertional dyspnea (HP:0002875)1.85073278
127Exercise intolerance (HP:0003546)1.85069265
128Pulmonary fibrosis (HP:0002206)1.84692653
129Deformed tarsal bones (HP:0008119)1.84547043
130Neoplasm of the colon (HP:0100273)1.84274451
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84102025
132Abnormality of the prostate (HP:0008775)1.83939023
133Abnormality of the calcaneus (HP:0008364)1.83647410
134Abnormal mitochondria in muscle tissue (HP:0008316)1.83038918
135* IgM deficiency (HP:0002850)1.83024466
136Poor head control (HP:0002421)1.80465704
137Squamous cell carcinoma (HP:0002860)1.80011080
138Abnormal lung lobation (HP:0002101)1.79726326
139Abnormality of T cell physiology (HP:0011840)1.78761777
140Multiple enchondromatosis (HP:0005701)1.77813825
141Abnormality of the umbilical cord (HP:0010881)1.77785741
142Emotional lability (HP:0000712)1.76776834
143Pancreatic islet-cell hyperplasia (HP:0004510)1.75294701
144Abnormality of T cells (HP:0002843)1.75270293
145Testicular atrophy (HP:0000029)1.70960370
146Hypoglycemic coma (HP:0001325)1.68751064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.53426320
2WEE14.27682782
3EIF2AK13.49066826
4TSSK63.40002902
5STK163.36574158
6VRK23.31371190
7CDC73.16790797
8PBK2.65749512
9ACVR1B2.63508713
10EIF2AK32.60470223
11NUAK12.41145204
12BRSK22.39576861
13MKNK12.26511969
14NME22.23615801
15TRIM282.22113828
16VRK12.19568185
17SRPK12.13842235
18CCNB12.05621102
19PASK1.96088148
20PLK41.92976413
21TESK21.91101122
22NEK11.84462187
23KDR1.79688309
24OBSCN1.78239302
25NEK21.72220217
26MKNK21.69879807
27TGFBR11.66509868
28DYRK31.63166654
29PLK11.54068116
30PLK31.52022246
31RPS6KB21.46369088
32ERBB31.43951669
33FLT31.43408753
34PIM21.42321179
35ATR1.42047185
36CDK71.41209078
37MAP4K21.41036888
38RPS6KA41.38107233
39BRSK11.35957164
40AURKB1.35797347
41TTK1.31228699
42PDK21.20087989
43BCR1.19681662
44ZAK1.15685594
45TLK11.15493706
46CDK81.14529695
47MAP4K11.10470479
48CSNK1G31.08845601
49CSNK1G11.07811307
50TEC1.06866891
51BCKDK1.03708216
52NME10.95075284
53PAK40.93958533
54KIT0.93797283
55CSNK1A1L0.90293227
56CHEK20.89952644
57AURKA0.89319238
58MAPKAPK30.87778855
59SCYL20.87364139
60MAP3K80.87177569
61MAP2K30.84375137
62TXK0.83209787
63BTK0.81529467
64CDK40.81455448
65LATS10.77658442
66CDK190.77599190
67WNK30.77120575
68TAF10.75261429
69ZAP700.74186691
70CHEK10.73593430
71CSNK1G20.73464720
72TAOK30.72691859
73ARAF0.71913382
74TESK10.71451300
75EIF2AK20.70872801
76CSNK2A10.69295363
77PIM10.68555459
78MST40.68084954
79MAP3K30.67265049
80EEF2K0.66787567
81PHKG10.65946490
82PHKG20.65946490
83STK100.65392842
84IRAK40.65315365
85CSNK2A20.64513849
86BMPR1B0.62025369
87DAPK10.60337600
88LRRK20.59444542
89EPHA20.58083616
90MAP3K120.58015032
91TAOK20.57872430
92MAP3K110.57614578
93ITK0.56799767
94JAK30.53080014
95PLK20.52377322
96ATM0.51071147
97CSF1R0.49631661
98CDK20.48621572
99STK40.45916285
100GRK10.44656430
101OXSR10.43231888
102ALK0.43163272
103RPS6KA50.42621235
104IRAK30.41601461
105CLK10.40227571
106PAK10.39231413
107PDK30.34798648
108PDK40.34798648
109MYLK0.34601691
110BRAF0.34098291
111CDK10.34067079
112CDK60.32305708
113SIK30.31847832
114NLK0.31807281
115LIMK10.31795164
116PRKCI0.31105112
117LYN0.29809618
118ILK0.29319624
119MAP2K60.28228480
120AKT30.27362739
121NEK60.27126028
122TIE10.24002513
123YES10.23640286
124PIK3CG0.23592607
125MAPKAPK50.23506654
126BRD40.23115681
127CAMKK20.22992655
128IKBKB0.22970979
129NEK90.22004742
130RAF10.21281342
131CSNK1A10.20271697
132STK30.19742849

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05588574
2Mismatch repair_Homo sapiens_hsa034304.19820228
3Proteasome_Homo sapiens_hsa030504.09691226
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70989907
5Ribosome_Homo sapiens_hsa030103.68457970
6RNA polymerase_Homo sapiens_hsa030203.43929410
7Spliceosome_Homo sapiens_hsa030403.22340637
8Base excision repair_Homo sapiens_hsa034103.02778176
9Nucleotide excision repair_Homo sapiens_hsa034202.93684389
10RNA transport_Homo sapiens_hsa030132.85265694
11Homologous recombination_Homo sapiens_hsa034402.84290249
12Pyrimidine metabolism_Homo sapiens_hsa002402.67552003
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48789953
14Cell cycle_Homo sapiens_hsa041102.43290188
15One carbon pool by folate_Homo sapiens_hsa006702.10288486
16Non-homologous end-joining_Homo sapiens_hsa034501.96717940
17RNA degradation_Homo sapiens_hsa030181.94068826
18Propanoate metabolism_Homo sapiens_hsa006401.90829257
19Basal transcription factors_Homo sapiens_hsa030221.89206180
20Fanconi anemia pathway_Homo sapiens_hsa034601.80543927
21Protein export_Homo sapiens_hsa030601.64993252
22Fatty acid elongation_Homo sapiens_hsa000621.60313240
23Purine metabolism_Homo sapiens_hsa002301.57024196
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55416254
25p53 signaling pathway_Homo sapiens_hsa041151.42880873
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35093197
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33709690
28Folate biosynthesis_Homo sapiens_hsa007901.28505076
29mRNA surveillance pathway_Homo sapiens_hsa030151.22378839
30Epstein-Barr virus infection_Homo sapiens_hsa051691.19772575
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18211672
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10968248
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09086635
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.05730618
35Antigen processing and presentation_Homo sapiens_hsa046121.01264030
36Pentose phosphate pathway_Homo sapiens_hsa000300.98311214
37Vitamin B6 metabolism_Homo sapiens_hsa007500.96607546
38Selenocompound metabolism_Homo sapiens_hsa004500.92772100
39Primary immunodeficiency_Homo sapiens_hsa053400.88385565
40Caffeine metabolism_Homo sapiens_hsa002320.86758950
41Herpes simplex infection_Homo sapiens_hsa051680.86748998
42Biosynthesis of amino acids_Homo sapiens_hsa012300.86512299
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.86390154
44Parkinsons disease_Homo sapiens_hsa050120.82481686
45Peroxisome_Homo sapiens_hsa041460.78044979
46N-Glycan biosynthesis_Homo sapiens_hsa005100.75319957
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73775489
48Sulfur relay system_Homo sapiens_hsa041220.71867874
49Systemic lupus erythematosus_Homo sapiens_hsa053220.71637441
50Legionellosis_Homo sapiens_hsa051340.71599755
51Steroid biosynthesis_Homo sapiens_hsa001000.71175624
52Viral carcinogenesis_Homo sapiens_hsa052030.70852414
53Huntingtons disease_Homo sapiens_hsa050160.70509395
54Oocyte meiosis_Homo sapiens_hsa041140.67888212
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67457785
56Autoimmune thyroid disease_Homo sapiens_hsa053200.67009243
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65767549
58Butanoate metabolism_Homo sapiens_hsa006500.64745061
59Carbon metabolism_Homo sapiens_hsa012000.62162825
60Thyroid cancer_Homo sapiens_hsa052160.62028734
61Type I diabetes mellitus_Homo sapiens_hsa049400.60794738
62Cardiac muscle contraction_Homo sapiens_hsa042600.60517463
63Oxidative phosphorylation_Homo sapiens_hsa001900.59605472
64Fatty acid metabolism_Homo sapiens_hsa012120.59511932
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58817921
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57546050
67HTLV-I infection_Homo sapiens_hsa051660.57232679
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55346201
69Graft-versus-host disease_Homo sapiens_hsa053320.54563600
70Fatty acid degradation_Homo sapiens_hsa000710.53917641
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.53670281
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53353521
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53232222
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53180580
75Glutathione metabolism_Homo sapiens_hsa004800.51443541
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48805777
77Viral myocarditis_Homo sapiens_hsa054160.46697650
78Measles_Homo sapiens_hsa051620.45880414
79Regulation of autophagy_Homo sapiens_hsa041400.44837548
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44549982
81Sulfur metabolism_Homo sapiens_hsa009200.43666075
82Shigellosis_Homo sapiens_hsa051310.42272980
83Galactose metabolism_Homo sapiens_hsa000520.39239600
84Fructose and mannose metabolism_Homo sapiens_hsa000510.37350237
85Metabolic pathways_Homo sapiens_hsa011000.36967177
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36625764
87Hematopoietic cell lineage_Homo sapiens_hsa046400.35885956
88beta-Alanine metabolism_Homo sapiens_hsa004100.34813910
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34365655
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33095332
91Phototransduction_Homo sapiens_hsa047440.31872543
92Small cell lung cancer_Homo sapiens_hsa052220.30029052
93Apoptosis_Homo sapiens_hsa042100.27632638
94Hepatitis B_Homo sapiens_hsa051610.26460330
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.25644697
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25641129
97Tryptophan metabolism_Homo sapiens_hsa003800.25484172
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25418445
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.24853871
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24536612
101Allograft rejection_Homo sapiens_hsa053300.21349585
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21133555
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20572306
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19632821
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19346765
106Alcoholism_Homo sapiens_hsa050340.18264227
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.17551775
108Rheumatoid arthritis_Homo sapiens_hsa053230.15096215
109Alzheimers disease_Homo sapiens_hsa050100.14147361
110Pyruvate metabolism_Homo sapiens_hsa006200.13687169
111Influenza A_Homo sapiens_hsa051640.13295006
112Renin-angiotensin system_Homo sapiens_hsa046140.12792203
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12373151
114Arginine biosynthesis_Homo sapiens_hsa002200.12088548
115Arachidonic acid metabolism_Homo sapiens_hsa005900.11810630
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10564384
117HIF-1 signaling pathway_Homo sapiens_hsa040660.09725365
118MicroRNAs in cancer_Homo sapiens_hsa052060.08163688
119Asthma_Homo sapiens_hsa053100.07634333
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07463650
121Colorectal cancer_Homo sapiens_hsa052100.07434943
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.06913135
123Arginine and proline metabolism_Homo sapiens_hsa003300.05662186
124Circadian rhythm_Homo sapiens_hsa047100.05170778
125Acute myeloid leukemia_Homo sapiens_hsa052210.04823529
126TGF-beta signaling pathway_Homo sapiens_hsa043500.04740221

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