CNGA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.98773192
2protein polyglutamylation (GO:0018095)7.72777535
3adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.38361582
4regulation of cilium movement (GO:0003352)6.86866365
5axonemal dynein complex assembly (GO:0070286)6.03229457
6intraciliary transport (GO:0042073)5.29829470
7microtubule severing (GO:0051013)5.25460370
8negative regulation of cytosolic calcium ion concentration (GO:0051481)5.19530648
9axoneme assembly (GO:0035082)5.18111241
10activation of protein kinase A activity (GO:0034199)5.11442391
11cilium movement (GO:0003341)5.07269398
12cilium morphogenesis (GO:0060271)5.04680070
13antibacterial humoral response (GO:0019731)4.92297581
14regulation of chromatin binding (GO:0035561)4.90741278
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.83372770
16auditory receptor cell differentiation (GO:0042491)4.73331466
17dopamine receptor signaling pathway (GO:0007212)4.67986115
18innate immune response in mucosa (GO:0002227)4.65423099
19antimicrobial humoral response (GO:0019730)4.53389914
20cAMP biosynthetic process (GO:0006171)4.44833640
21response to caffeine (GO:0031000)4.23916842
22behavioral response to cocaine (GO:0048148)4.17346814
23regulation of microtubule-based movement (GO:0060632)4.02514447
24adipose tissue development (GO:0060612)3.91803864
25mucosal immune response (GO:0002385)3.89351757
26detection of calcium ion (GO:0005513)3.84633826
27neuron cell-cell adhesion (GO:0007158)3.81402865
28regulation of sodium ion transmembrane transporter activity (GO:2000649)3.81063229
29atrial cardiac muscle cell action potential (GO:0086014)3.73034181
30organ or tissue specific immune response (GO:0002251)3.67778034
31regulation of heart rate by cardiac conduction (GO:0086091)3.67266272
32axonal fasciculation (GO:0007413)3.64861441
33cellular response to glucagon stimulus (GO:0071377)3.60829331
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.58308706
35regulation of protein kinase A signaling (GO:0010738)3.57250310
36epithelial cilium movement (GO:0003351)3.57200743
37photoreceptor cell maintenance (GO:0045494)3.56808192
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.56402710
39ventricular system development (GO:0021591)3.52840325
40left/right axis specification (GO:0070986)3.52457675
41response to gravity (GO:0009629)3.47999525
42microtubule bundle formation (GO:0001578)3.34395408
43magnesium ion transport (GO:0015693)3.32220866
44regulation of sodium ion transmembrane transport (GO:1902305)3.32183305
45response to amphetamine (GO:0001975)3.31647248
46protein heterotetramerization (GO:0051290)3.23840312
47positive regulation of insulin receptor signaling pathway (GO:0046628)3.23158186
48natural killer cell mediated immunity (GO:0002228)3.22961116
49natural killer cell mediated cytotoxicity (GO:0042267)3.22961116
50cellular copper ion homeostasis (GO:0006878)3.14043371
51negative regulation of microtubule polymerization (GO:0031115)3.12349099
52negative regulation of complement activation (GO:0045916)3.12074584
53membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.09768996
54negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08845029
55phosphorelay signal transduction system (GO:0000160)3.08762190
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08309759
57mating behavior (GO:0007617)3.08000057
58cAMP metabolic process (GO:0046058)3.07100665
59regulation of synapse structural plasticity (GO:0051823)3.04058385
60peptidyl-glutamic acid modification (GO:0018200)3.03080049
61adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.02882357
62negative regulation of glycogen biosynthetic process (GO:0045719)3.00713890
63cardiac conduction (GO:0061337)3.00431165
64* sensory perception of smell (GO:0007608)23.7225675
65facial nerve structural organization (GO:0021612)2.96214720
66nucleoside diphosphate phosphorylation (GO:0006165)2.95952150
67glutamate secretion (GO:0014047)2.94843579
68hair cell differentiation (GO:0035315)2.94038928
69olfactory bulb development (GO:0021772)2.93789899
70regulation of sodium ion transport (GO:0002028)2.90942966
71calcium-mediated signaling using intracellular calcium source (GO:0035584)2.89505963
72potassium ion homeostasis (GO:0055075)2.88282452
73detection of light stimulus involved in sensory perception (GO:0050962)2.83314352
74detection of light stimulus involved in visual perception (GO:0050908)2.83314352
75histone H2B ubiquitination (GO:0033523)2.82969194
76potassium ion export (GO:0071435)2.82669682
77inner ear receptor cell differentiation (GO:0060113)2.80455102
78response to glucagon (GO:0033762)2.79714736
79ADP metabolic process (GO:0046031)2.73105825
80membrane repolarization during action potential (GO:0086011)2.72264563
81negative regulation of glycogen metabolic process (GO:0070874)2.72169813
82cilium assembly (GO:0042384)2.71257303
83response to inactivity (GO:0014854)2.68381120
84cilium or flagellum-dependent cell motility (GO:0001539)2.64319928
85negative regulation of protein activation cascade (GO:2000258)2.63875068
86brain morphogenesis (GO:0048854)2.63874273
87positive regulation of growth hormone secretion (GO:0060124)2.63515017
88connective tissue development (GO:0061448)2.61252520
89ganglion development (GO:0061548)2.59722151
90* cellular potassium ion transport (GO:0071804)2.59524213
91* potassium ion transmembrane transport (GO:0071805)2.59524213
92inositol phosphate dephosphorylation (GO:0046855)2.59404999
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59404999
94negative regulation of astrocyte differentiation (GO:0048712)2.58896691
95regulation of cell communication by electrical coupling (GO:0010649)2.57491458
96cellular response to electrical stimulus (GO:0071257)2.57404967
97neurogenesis (GO:0022008)2.56359171
98* sensory perception of chemical stimulus (GO:0007606)13.4290331
99protein insertion into membrane (GO:0051205)12.2445666
100protein localization to cilium (GO:0061512)10.1535457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.39611802
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97554660
3ZNF263_19887448_ChIP-Seq_K562_Human3.52818837
4DROSHA_22980978_ChIP-Seq_HELA_Human2.99202660
5GBX2_23144817_ChIP-Seq_PC3_Human2.84241553
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74633155
7TAF15_26573619_Chip-Seq_HEK293_Human2.66068291
8BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.31962230
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.01913683
10LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01600845
11ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.95049617
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88886562
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88886562
14CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85347156
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83062535
16GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.82074267
17SRY_22984422_ChIP-ChIP_TESTIS_Rat1.81394707
18AHR_22903824_ChIP-Seq_MCF-7_Human1.73733195
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72397183
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72397183
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.69073192
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68187039
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61168008
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61106559
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59316591
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.58707233
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.57655151
28REST_21632747_ChIP-Seq_MESCs_Mouse1.55008739
29KDM2B_26808549_Chip-Seq_K562_Human1.53707706
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53194203
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53083699
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.52186749
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48789444
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45603779
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40467185
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39025472
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38854864
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38746656
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.36266060
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36151824
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35405689
42OCT4_20526341_ChIP-Seq_ESCs_Human1.25890971
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25729415
44GATA3_27048872_Chip-Seq_THYMUS_Human1.25625148
45TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24603678
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.24275652
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23368749
48* RNF2_27304074_Chip-Seq_NSC_Mouse1.22130949
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21290548
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20922021
51P300_19829295_ChIP-Seq_ESCs_Human1.19939582
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19108521
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.16750223
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16746540
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15413457
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.14390287
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.13704222
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13304147
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12082650
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11444829
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.10589984
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.09491371
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08747888
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.08064008
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06687916
66SMAD4_21741376_ChIP-Seq_HESCs_Human1.06267128
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05759619
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.05623053
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05244413
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05085301
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04142885
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02049656
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01996724
74RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99439777
75RING1B_27294783_Chip-Seq_NPCs_Mouse0.98718777
76GF1_26923725_Chip-Seq_HPCs_Mouse0.97941805
77TAF2_19829295_ChIP-Seq_ESCs_Human0.96927830
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96591166
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96271464
80EZH2_27304074_Chip-Seq_ESCs_Mouse0.94500358
81CTCF_20526341_ChIP-Seq_ESCs_Human0.91814728
82TCF4_22108803_ChIP-Seq_LS180_Human0.91726974
83VDR_22108803_ChIP-Seq_LS180_Human0.91663556
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90833447
85TAL1_26923725_Chip-Seq_HPCs_Mouse0.89970410
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89568037
87LXR_22292898_ChIP-Seq_THP-1_Human0.88314118
88RUNX2_22187159_ChIP-Seq_PCA_Human0.87946250
89NCOR_22424771_ChIP-Seq_293T_Human0.87533626
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87128814
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86999601
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86125724
93E2F1_20622854_ChIP-Seq_HELA_Human0.85856352
94NANOG_20526341_ChIP-Seq_ESCs_Human0.85628007
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85549174
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85377801
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84289693
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83102265
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.82539171
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81208817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.48196737
2MP0005394_taste/olfaction_phenotype4.23700208
3MP0005499_abnormal_olfactory_system4.23700208
4MP0003806_abnormal_nucleotide_metabolis3.39226903
5MP0002822_catalepsy2.52811879
6MP0001485_abnormal_pinna_reflex2.52233466
7MP0005645_abnormal_hypothalamus_physiol2.36140755
8* MP0001984_abnormal_olfaction15.0415292
9MP0000516_abnormal_urinary_system1.86238845
10MP0005367_renal/urinary_system_phenotyp1.86238845
11* MP0002184_abnormal_innervation1.74110211
12MP0005084_abnormal_gallbladder_morpholo1.63307613
13MP0002928_abnormal_bile_duct1.56679426
14MP0002160_abnormal_reproductive_system1.54470109
15MP0010234_abnormal_vibrissa_follicle1.51538692
16MP0003252_abnormal_bile_duct1.46318726
17MP0001542_abnormal_bone_strength1.44666113
18MP0002734_abnormal_mechanical_nocicepti1.44460472
19MP0005646_abnormal_pituitary_gland1.40374726
20MP0002653_abnormal_ependyma_morphology1.38731104
21MP0001486_abnormal_startle_reflex1.32729963
22MP0003880_abnormal_central_pattern1.32428297
23MP0002557_abnormal_social/conspecific_i1.30990929
24* MP0002752_abnormal_somatic_nervous1.29337717
25MP0003878_abnormal_ear_physiology1.28832826
26MP0005377_hearing/vestibular/ear_phenot1.28832826
27MP0002909_abnormal_adrenal_gland1.26832041
28MP0005410_abnormal_fertilization1.23996763
29MP0002272_abnormal_nervous_system1.22899289
30MP0001188_hyperpigmentation1.19548015
31MP0002233_abnormal_nose_morphology1.16978017
32MP0004742_abnormal_vestibular_system1.09111540
33MP0000372_irregular_coat_pigmentation1.07885765
34MP0002877_abnormal_melanocyte_morpholog1.06205486
35MP0008875_abnormal_xenobiotic_pharmacok1.04399469
36MP0001293_anophthalmia1.02911099
37MP0000778_abnormal_nervous_system0.99651476
38* MP0002882_abnormal_neuron_morphology0.98277574
39MP0005551_abnormal_eye_electrophysiolog0.92984878
40* MP0003635_abnormal_synaptic_transmissio0.88895860
41MP0009333_abnormal_splenocyte_physiolog0.86558801
42MP0002063_abnormal_learning/memory/cond0.85338968
43MP0004270_analgesia0.84117341
44MP0005058_abnormal_lysosome_morphology0.75064044
45MP0002102_abnormal_ear_morphology0.74699736
46MP0002229_neurodegeneration0.71240157
47MP0003634_abnormal_glial_cell0.70829480
48MP0006276_abnormal_autonomic_nervous0.69470877
49MP0002572_abnormal_emotion/affect_behav0.69210031
50* MP0002152_abnormal_brain_morphology0.69173322
51MP0004858_abnormal_nervous_system0.66964171
52MP0005389_reproductive_system_phenotype0.65709605
53MP0003942_abnormal_urinary_system0.65410501
54MP0005584_abnormal_enzyme/coenzyme_acti0.65238531
55MP0001970_abnormal_pain_threshold0.63674379
56MP0000631_abnormal_neuroendocrine_gland0.61269469
57MP0004133_heterotaxia0.60577697
58MP0004859_abnormal_synaptic_plasticity0.59619572
59MP0004145_abnormal_muscle_electrophysio0.59474478
60MP0001963_abnormal_hearing_physiology0.58623806
61MP0000003_abnormal_adipose_tissue0.58383772
62MP0002067_abnormal_sensory_capabilities0.58383328
63MP0002064_seizures0.57302624
64MP0000538_abnormal_urinary_bladder0.57068698
65MP0005623_abnormal_meninges_morphology0.57061094
66MP0005423_abnormal_somatic_nervous0.56879548
67MP0005195_abnormal_posterior_eye0.56457697
68MP0001529_abnormal_vocalization0.55413747
69MP0002896_abnormal_bone_mineralization0.55412804
70MP0000026_abnormal_inner_ear0.55159755
71MP0004147_increased_porphyrin_level0.54906842
72MP0005409_darkened_coat_color0.54640856
73* MP0004811_abnormal_neuron_physiology0.52341904
74MP0004782_abnormal_surfactant_physiolog0.52160209
75MP0003075_altered_response_to0.51709284
76MP0005165_increased_susceptibility_to0.50492428
77MP0005220_abnormal_exocrine_pancreas0.49487283
78MP0002092_abnormal_eye_morphology0.49110744
79MP0005174_abnormal_tail_pigmentation0.49061286
80MP0001666_abnormal_nutrient_absorption0.48886119
81MP0006082_CNS_inflammation0.48555096
82MP0005187_abnormal_penis_morphology0.47317197
83MP0008874_decreased_physiological_sensi0.44978550
84MP0003861_abnormal_nervous_system0.43562620
85MP0003693_abnormal_embryo_hatching0.42105063
86MP0010386_abnormal_urinary_bladder0.40979278
87MP0002295_abnormal_pulmonary_circulatio0.40541422
88MP0009745_abnormal_behavioral_response0.40489956
89MP0009765_abnormal_xenobiotic_induced0.39386086
90MP0003633_abnormal_nervous_system0.39340115
91MP0000049_abnormal_middle_ear0.38270472
92MP0002751_abnormal_autonomic_nervous0.37008696
93MP0001501_abnormal_sleep_pattern0.36649137
94MP0003195_calcinosis0.35293829
95MP0006036_abnormal_mitochondrial_physio0.34559838
96MP0006035_abnormal_mitochondrial_morpho0.33089600
97MP0000534_abnormal_ureter_morphology0.32298861
98MP0002066_abnormal_motor_capabilities/c0.32276365
99MP0003879_abnormal_hair_cell0.30500893
100MP0001270_distended_abdomen0.30276321

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)8.73142888
2Abnormal respiratory motile cilium physiology (HP:0012261)7.29946820
3Chronic bronchitis (HP:0004469)6.59048211
4Rhinitis (HP:0012384)6.48445585
5Limb dystonia (HP:0002451)6.06961475
6Bifid tongue (HP:0010297)5.84212145
7Abnormality of midbrain morphology (HP:0002418)5.40336601
8Molar tooth sign on MRI (HP:0002419)5.40336601
9Abnormality of macular pigmentation (HP:0008002)5.35349606
10Abnormal ciliary motility (HP:0012262)5.09982898
11Palpitations (HP:0001962)5.03380102
12Abnormal respiratory motile cilium morphology (HP:0005938)4.71398591
13Abnormal respiratory epithelium morphology (HP:0012253)4.71398591
14Bony spicule pigmentary retinopathy (HP:0007737)4.64054489
15Dysphonia (HP:0001618)4.56457629
16Abolished electroretinogram (ERG) (HP:0000550)4.15740590
17Hypochromic microcytic anemia (HP:0004840)3.75444010
18Atonic seizures (HP:0010819)3.70616654
19Bronchiectasis (HP:0002110)3.66635389
20Hypothermia (HP:0002045)3.66447802
21Chronic hepatic failure (HP:0100626)3.49680027
22Torticollis (HP:0000473)3.48321393
23Syncope (HP:0001279)3.19378528
24Postaxial hand polydactyly (HP:0001162)3.14302265
25Gait imbalance (HP:0002141)3.13900572
26Short nail (HP:0001799)3.11763729
27Abnormality of dentin (HP:0010299)3.10051650
28Craniofacial dystonia (HP:0012179)3.09950839
29Congenital primary aphakia (HP:0007707)3.04439561
30Poikilocytosis (HP:0004447)2.99932725
31Occipital encephalocele (HP:0002085)2.94625414
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.89803318
33Absent/shortened dynein arms (HP:0200106)2.89803318
34True hermaphroditism (HP:0010459)2.84204311
35Medial flaring of the eyebrow (HP:0010747)2.83751532
36Abnormality of sodium homeostasis (HP:0010931)2.83090971
37Focal dystonia (HP:0004373)2.82977341
38Nephrogenic diabetes insipidus (HP:0009806)2.82889555
39Oculomotor apraxia (HP:0000657)2.82770706
40Febrile seizures (HP:0002373)2.80618460
41Hyperglycinemia (HP:0002154)2.79569681
42Nephronophthisis (HP:0000090)2.74292312
43Pancreatic fibrosis (HP:0100732)2.70600977
44Central scotoma (HP:0000603)2.69729161
45Prolonged QT interval (HP:0001657)2.50080933
46Recurrent otitis media (HP:0000403)2.46513575
47Vacuolated lymphocytes (HP:0001922)2.42627421
48Vaginal atresia (HP:0000148)2.40579176
49Pancreatic cysts (HP:0001737)2.38073962
50Restlessness (HP:0000711)2.37364374
51Cystic liver disease (HP:0006706)2.36995015
52Bronchitis (HP:0012387)2.36914220
53Renal hypoplasia (HP:0000089)2.31401476
54Genital tract atresia (HP:0001827)2.29220095
55Poor coordination (HP:0002370)2.28541664
56Termporal pattern (HP:0011008)2.27103666
57Insidious onset (HP:0003587)2.27103666
58Anosmia (HP:0000458)2.25772936
59Absence seizures (HP:0002121)2.21828571
60Nasal polyposis (HP:0100582)2.19491947
61Constricted visual fields (HP:0001133)2.19101288
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13812245
63Xerostomia (HP:0000217)2.13017490
64Abnormality of the renal medulla (HP:0100957)2.12587381
65Bile duct proliferation (HP:0001408)2.07686395
66Abnormal biliary tract physiology (HP:0012439)2.07686395
67Aplasia/Hypoplasia of the lens (HP:0008063)2.07637513
68Abnormality of permanent molar morphology (HP:0011071)2.06325486
69Abnormality of the dental root (HP:0006486)2.06325486
70Taurodontia (HP:0000679)2.06325486
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7893974
72Agitation (HP:0000713)1.98054633
73Abnormality of molar morphology (HP:0011070)1.96133742
74Abnormality of molar (HP:0011077)1.96133742
75Furrowed tongue (HP:0000221)1.95860163
76Retinitis pigmentosa (HP:0000510)1.92179108
77Narrow forehead (HP:0000341)1.91295081
78Tubulointerstitial nephritis (HP:0001970)1.90297893
79Abnormality of the dental pulp (HP:0006479)1.88049885
80Sudden death (HP:0001699)1.87958463
81Recurrent sinusitis (HP:0011108)1.86235095
82Complete atrioventricular canal defect (HP:0001674)1.85444967
83Myokymia (HP:0002411)1.85364270
84Bradycardia (HP:0001662)1.80688594
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.77881973
86Primary atrial arrhythmia (HP:0001692)1.77188697
87Abnormal EKG (HP:0003115)1.75139394
88Aganglionic megacolon (HP:0002251)1.73764333
89Abnormality of the nasal mucosa (HP:0000433)1.70026212
90Supraventricular tachycardia (HP:0004755)1.68634014
91Abnormal rod and cone electroretinograms (HP:0008323)1.68232484
92Conjunctival hamartoma (HP:0100780)1.68076496
93Median cleft lip (HP:0000161)1.66679259
94Diminished motivation (HP:0000745)1.66528539
95Chronic sinusitis (HP:0011109)1.64454353
96Supraventricular arrhythmia (HP:0005115)1.62178865
97Sclerocornea (HP:0000647)1.61915200
98Dialeptic seizures (HP:0011146)1.61866823
99Focal seizures (HP:0007359)1.61645731
100Congenital hepatic fibrosis (HP:0002612)1.60567678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.85559733
2PHKG24.85559733
3ERBB33.83456504
4MAPK153.65898713
5PAK33.15565864
6CAMK2D2.93450741
7CAMK2B2.91457426
8DAPK22.85349532
9EEF2K2.70026968
10ARAF2.65208960
11ICK2.54752469
12MAPKAPK32.44833225
13CAMK2G2.37631024
14TRIB32.34675676
15STK38L2.29968948
16STK242.14294770
17CSNK1A1L1.94387678
18NUAK11.91393513
19STK161.76760167
20CSNK1G31.55980235
21ILK1.53731523
22CAMK1D1.41963547
23CAMKK21.36900112
24PIM21.36776334
25CAMK1G1.36310094
26CSNK1G21.31308092
27CSNK1G11.22676236
28RPS6KA21.21827514
29DAPK11.19998187
30PRKCG1.16669483
31FRK1.13833658
32HIPK21.08197302
33STK391.07942954
34STK381.03842822
35DYRK1B0.99108706
36MAP3K70.89907677
37CAMK2A0.88278975
38MAP2K70.86259002
39IRAK10.79884675
40MARK10.78793667
41TNK20.76799443
42TRPM70.76645009
43GRK60.76552170
44MAPK130.76499874
45CASK0.74336104
46BRAF0.70505742
47MINK10.69849636
48DYRK1A0.69410331
49DYRK30.67987081
50PRPF4B0.66631290
51TGFBR20.64147645
52CAMKK10.63197895
53MUSK0.61937511
54MAPKAPK50.60312208
55RIPK10.57814088
56MAP3K40.55740164
57DAPK30.52058232
58NTRK20.51093206
59MARK20.50937135
60CAMK40.50547397
61GRK50.50538922
62IRAK20.49835110
63AKT30.49699797
64PRKAA20.49482393
65SRPK10.49439403
66PKN10.45344955
67MAP2K20.44970893
68PRKG20.44224688
69MAPK110.42618935
70PRKCQ0.42476498
71SIK20.39459756
72ERBB20.38970062
73MAPKAPK20.38507455
74LMTK20.36839842
75MAP3K140.36673428
76CDK50.36670078
77TTK0.36319086
78PRKD20.35979314
79MAPK70.35752572
80TYRO30.35407779
81TNIK0.35064658
82MAP2K40.34984202
83STK110.34892766
84AKT20.34336824
85CAMK10.34229396
86WNK40.34016091
87SGK4940.32494742
88SGK2230.32494742
89EGFR0.32142697
90PRKAA10.30571205
91TXK0.30245417
92PRKACG0.30205288
93RPS6KA40.30171269
94MAP3K20.29969431
95PRKCZ0.29946600
96PRKD30.27571787
97FYN0.27248839
98PRKD10.26323025
99PLK20.26102569
100PRKACA0.25191343

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.12873539
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.00592318
3* Olfactory transduction_Homo sapiens_hsa0474011.6773192
4Morphine addiction_Homo sapiens_hsa050321.84819638
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80101283
6Circadian entrainment_Homo sapiens_hsa047131.68463233
7Taste transduction_Homo sapiens_hsa047421.66764229
8Insulin secretion_Homo sapiens_hsa049111.62061604
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58604852
10Ovarian steroidogenesis_Homo sapiens_hsa049131.51463439
11Fatty acid biosynthesis_Homo sapiens_hsa000611.49139608
12Dopaminergic synapse_Homo sapiens_hsa047281.47360030
13Gastric acid secretion_Homo sapiens_hsa049711.43201948
14Vibrio cholerae infection_Homo sapiens_hsa051101.43200957
15Salivary secretion_Homo sapiens_hsa049701.40946009
16Thyroid hormone synthesis_Homo sapiens_hsa049181.34317419
17Bile secretion_Homo sapiens_hsa049761.34284678
18Cholinergic synapse_Homo sapiens_hsa047251.32168399
19GABAergic synapse_Homo sapiens_hsa047271.31949117
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31661945
21Histidine metabolism_Homo sapiens_hsa003401.30728055
22Glutamatergic synapse_Homo sapiens_hsa047241.27502029
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27211740
24* cAMP signaling pathway_Homo sapiens_hsa040241.25451573
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13532903
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10461221
27Synaptic vesicle cycle_Homo sapiens_hsa047211.03175286
28beta-Alanine metabolism_Homo sapiens_hsa004101.02552973
29Alcoholism_Homo sapiens_hsa050341.01357768
30Estrogen signaling pathway_Homo sapiens_hsa049151.00914522
31Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99887260
32Calcium signaling pathway_Homo sapiens_hsa040200.95919104
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93687713
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92563250
35GnRH signaling pathway_Homo sapiens_hsa049120.89895155
36Amphetamine addiction_Homo sapiens_hsa050310.84894860
37Sphingolipid metabolism_Homo sapiens_hsa006000.84444577
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83592029
39Other glycan degradation_Homo sapiens_hsa005110.82824115
40Parkinsons disease_Homo sapiens_hsa050120.80241192
41Melanogenesis_Homo sapiens_hsa049160.78258019
42Gap junction_Homo sapiens_hsa045400.73713508
43ABC transporters_Homo sapiens_hsa020100.71425289
44Renin secretion_Homo sapiens_hsa049240.67011621
45Glucagon signaling pathway_Homo sapiens_hsa049220.64531015
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63971653
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62236121
48Purine metabolism_Homo sapiens_hsa002300.59933490
49Oxytocin signaling pathway_Homo sapiens_hsa049210.59066865
50Pancreatic secretion_Homo sapiens_hsa049720.56504708
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56202610
52Dilated cardiomyopathy_Homo sapiens_hsa054140.53931760
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.50164521
54Long-term potentiation_Homo sapiens_hsa047200.49627184
55Alzheimers disease_Homo sapiens_hsa050100.49276892
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.48702250
57Arachidonic acid metabolism_Homo sapiens_hsa005900.44785017
58Rap1 signaling pathway_Homo sapiens_hsa040150.44579231
59Cocaine addiction_Homo sapiens_hsa050300.44282969
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44243282
61Systemic lupus erythematosus_Homo sapiens_hsa053220.44049436
62Sulfur metabolism_Homo sapiens_hsa009200.41940595
63Oocyte meiosis_Homo sapiens_hsa041140.41219958
64Serotonergic synapse_Homo sapiens_hsa047260.40266273
65Insulin signaling pathway_Homo sapiens_hsa049100.39736650
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38942267
67Collecting duct acid secretion_Homo sapiens_hsa049660.38570660
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36501257
69Cardiac muscle contraction_Homo sapiens_hsa042600.35168362
70Fatty acid degradation_Homo sapiens_hsa000710.33747698
71Propanoate metabolism_Homo sapiens_hsa006400.33043456
72Nitrogen metabolism_Homo sapiens_hsa009100.31918153
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.31406064
74Amoebiasis_Homo sapiens_hsa051460.30807052
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30723129
76Oxidative phosphorylation_Homo sapiens_hsa001900.29937270
77N-Glycan biosynthesis_Homo sapiens_hsa005100.29699087
78Ras signaling pathway_Homo sapiens_hsa040140.29557786
79Axon guidance_Homo sapiens_hsa043600.29538097
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.28333015
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27841834
82Pyruvate metabolism_Homo sapiens_hsa006200.26500580
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25976805
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25604427
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25406332
86Glioma_Homo sapiens_hsa052140.23440434
87Starch and sucrose metabolism_Homo sapiens_hsa005000.22826806
88Chemokine signaling pathway_Homo sapiens_hsa040620.22538681
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21595140
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.20379652
91Peroxisome_Homo sapiens_hsa041460.20190923
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.18190282
93Dorso-ventral axis formation_Homo sapiens_hsa043200.17283190
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16789036
95Pancreatic cancer_Homo sapiens_hsa052120.16322748
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15025334
97Huntingtons disease_Homo sapiens_hsa050160.14153452
98Nicotine addiction_Homo sapiens_hsa050330.12643699
99Arginine biosynthesis_Homo sapiens_hsa002200.12030033
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11780300

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