CNGA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.22093208
2postsynaptic membrane organization (GO:0001941)6.88862380
3behavioral response to nicotine (GO:0035095)6.79714706
4presynaptic membrane assembly (GO:0097105)6.69864505
5presynaptic membrane organization (GO:0097090)5.76959865
6nucleobase catabolic process (GO:0046113)5.72079665
7daunorubicin metabolic process (GO:0044597)4.62958399
8polyketide metabolic process (GO:0030638)4.62958399
9doxorubicin metabolic process (GO:0044598)4.62958399
10auditory behavior (GO:0031223)4.57080382
11neuron cell-cell adhesion (GO:0007158)4.53868866
12axonal fasciculation (GO:0007413)4.52884921
13epithelial cilium movement (GO:0003351)4.48882975
14neurotransmitter-gated ion channel clustering (GO:0072578)4.39871145
15retinal ganglion cell axon guidance (GO:0031290)4.34129835
16superoxide anion generation (GO:0042554)4.33770097
17synaptic transmission, cholinergic (GO:0007271)4.30387667
18mechanosensory behavior (GO:0007638)4.23987679
19vocalization behavior (GO:0071625)4.09452327
20cilium movement (GO:0003341)4.07488093
21neuronal action potential propagation (GO:0019227)3.99461646
22synapse assembly (GO:0007416)3.99150222
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.95207446
24regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.92983013
25neuron recognition (GO:0008038)3.83612734
26dendritic spine morphogenesis (GO:0060997)3.76274100
27negative regulation of cytosolic calcium ion concentration (GO:0051481)3.75338433
28regulation of beta-amyloid formation (GO:1902003)3.75119109
29protein localization to synapse (GO:0035418)3.72333528
30calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.70720555
31neuromuscular synaptic transmission (GO:0007274)3.68090975
32response to peptidoglycan (GO:0032494)3.64306124
33neurotransmitter uptake (GO:0001504)3.59201036
34negative regulation of mast cell activation (GO:0033004)3.58672942
35dendritic cell chemotaxis (GO:0002407)3.56746560
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49956931
37positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46215134
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44271198
39central nervous system projection neuron axonogenesis (GO:0021952)3.39812354
40regulation of collateral sprouting (GO:0048670)3.33391954
41cellular response to cholesterol (GO:0071397)3.32878121
42detection of other organism (GO:0098543)3.30373048
43regulation of respiratory system process (GO:0044065)3.25439033
44cerebral cortex radially oriented cell migration (GO:0021799)3.24508645
45positive regulation of cellular amide metabolic process (GO:0034250)3.23258737
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.22407139
47response to auditory stimulus (GO:0010996)3.22122211
48positive regulation of synapse assembly (GO:0051965)3.20911854
49axonemal dynein complex assembly (GO:0070286)3.18393329
50positive regulation of gastrulation (GO:2000543)3.16182031
51cellular response to sterol (GO:0036315)3.14908952
52central nervous system neuron axonogenesis (GO:0021955)3.13230543
53transmission of nerve impulse (GO:0019226)3.10587318
54replicative senescence (GO:0090399)3.09164009
55positive regulation of growth hormone secretion (GO:0060124)3.09015126
56nonmotile primary cilium assembly (GO:0035058)3.04420410
57dendritic cell migration (GO:0036336)3.03639349
58protein K6-linked ubiquitination (GO:0085020)3.02316972
59appendage development (GO:0048736)3.02049026
60limb development (GO:0060173)3.02049026
61cilium or flagellum-dependent cell motility (GO:0001539)3.01122215
62detection of bacterium (GO:0016045)2.99586691
63regulation of heat generation (GO:0031650)2.99491957
64neuron fate determination (GO:0048664)2.99214473
65intraciliary transport (GO:0042073)2.96867132
66axoneme assembly (GO:0035082)2.96336495
67kinetochore assembly (GO:0051382)2.95769630
68response to muramyl dipeptide (GO:0032495)2.95618120
69establishment of mitochondrion localization (GO:0051654)2.90372765
70regulation of synaptic transmission, glutamatergic (GO:0051966)2.89875429
71neuronal ion channel clustering (GO:0045161)2.89585768
72olfactory bulb development (GO:0021772)2.89361419
73lysine catabolic process (GO:0006554)2.89221075
74lysine metabolic process (GO:0006553)2.89221075
75regulation of synapse structural plasticity (GO:0051823)2.87901071
76synapse organization (GO:0050808)2.86995123
77regulation of cilium movement (GO:0003352)2.86727326
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85616962
79behavioral response to ethanol (GO:0048149)2.85558193
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.83669199
81regulation of fever generation (GO:0031620)2.83372172
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83189351
83rRNA methylation (GO:0031167)2.82658988
84ganglion development (GO:0061548)2.81571434
85interferon-gamma production (GO:0032609)2.81304676
86cilium organization (GO:0044782)2.80437512
87cilium assembly (GO:0042384)2.80261423
88sequestering of actin monomers (GO:0042989)2.78746012
89histamine secretion (GO:0001821)2.78675159
90mismatch repair (GO:0006298)2.78334566
91base-excision repair, AP site formation (GO:0006285)2.77937900
92protein localization to cilium (GO:0061512)2.77777473
93DNA catabolic process, exonucleolytic (GO:0000738)2.77716105
94cilium morphogenesis (GO:0060271)2.77579242
95tRNA methylation (GO:0030488)2.77051562
96negative regulation of axonogenesis (GO:0050771)2.76795967
97regulation of hexokinase activity (GO:1903299)2.75962322
98regulation of glucokinase activity (GO:0033131)2.75962322
99CENP-A containing nucleosome assembly (GO:0034080)2.75128928
100regulation of growth hormone secretion (GO:0060123)2.74871284
101negative regulation of viral genome replication (GO:0045071)2.73934178
102rRNA modification (GO:0000154)2.73799222
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71730622
104kinetochore organization (GO:0051383)2.70418939
105negative regulation of dendrite development (GO:2000171)2.69748651
106positive regulation of heat generation (GO:0031652)2.68660838
107regulation of synapse assembly (GO:0051963)2.67860388
108glial cell proliferation (GO:0014009)2.67135501
109regulation of microtubule-based movement (GO:0060632)2.66974021
110regulation of amyloid precursor protein catabolic process (GO:1902991)2.66657369
111chromatin remodeling at centromere (GO:0031055)2.66648855
112brain morphogenesis (GO:0048854)2.65344982
113L-glutamate transport (GO:0015813)2.64769571
114cellular ketone body metabolic process (GO:0046950)2.64194271
115negative regulation of neurotransmitter transport (GO:0051589)2.63993514
116alkaloid metabolic process (GO:0009820)2.62994935
117energy homeostasis (GO:0097009)2.62242802
118adult walking behavior (GO:0007628)2.62150695
119DNA dealkylation (GO:0035510)2.61646785
120negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61583071
121regulation of activation of Janus kinase activity (GO:0010533)2.61516982
122dopaminergic neuron differentiation (GO:0071542)2.61227875
123positive regulation of interleukin-1 beta secretion (GO:0050718)2.60216906
124acidic amino acid transport (GO:0015800)2.59221267
125natural killer cell activation involved in immune response (GO:0002323)2.58674967
126platelet dense granule organization (GO:0060155)2.57834599
127replication fork processing (GO:0031297)2.57810603
128synaptic vesicle maturation (GO:0016188)2.57518809
129regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57084099
130regulation of mast cell activation (GO:0033003)2.56976168
131glycosphingolipid biosynthetic process (GO:0006688)2.56837739
132cytochrome complex assembly (GO:0017004)2.56526734
133response to lipoprotein particle (GO:0055094)2.55764312
134cellular response to exogenous dsRNA (GO:0071360)2.55583305
135reciprocal meiotic recombination (GO:0007131)2.54557969
136reciprocal DNA recombination (GO:0035825)2.54557969
137negative regulation of protein oligomerization (GO:0032460)2.53769388
138intra-S DNA damage checkpoint (GO:0031573)2.53542491
139regulation of RIG-I signaling pathway (GO:0039535)2.52157610
140neural tube formation (GO:0001841)2.52075836
141aminoglycoside antibiotic metabolic process (GO:0030647)2.51910107
142cranial nerve development (GO:0021545)2.51891499
143detection of molecule of bacterial origin (GO:0032490)2.51540538
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.50773901
145photoreceptor cell maintenance (GO:0045494)2.50167002
146positive regulation of neuroblast proliferation (GO:0002052)2.49850642
147CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49653307
148cellular response to interferon-beta (GO:0035458)2.46604111
149positive regulation of antigen processing and presentation (GO:0002579)2.46354692
150G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.45525688
151neutrophil activation involved in immune response (GO:0002283)2.45178273
152DNA strand renaturation (GO:0000733)2.44928528
153production of molecular mediator involved in inflammatory response (GO:0002532)2.44519687
154meiotic chromosome segregation (GO:0045132)2.43869725
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42332385
156DNA synthesis involved in DNA repair (GO:0000731)2.41817166
157DNA double-strand break processing (GO:0000729)2.41622749
158adenosine metabolic process (GO:0046085)2.40670047
159neutrophil activation (GO:0042119)2.40319627
160mannosylation (GO:0097502)2.39797747
161microtubule depolymerization (GO:0007019)2.39758651
162response to host immune response (GO:0052572)2.38362136
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38362136
164regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.37360923
165lipoxygenase pathway (GO:0019372)2.36639743
166telomere maintenance via recombination (GO:0000722)2.36175187
167cellular extravasation (GO:0045123)2.35898630
168DNA deamination (GO:0045006)2.35688162
169histamine transport (GO:0051608)2.35506095
170positive regulation of interleukin-1 secretion (GO:0050716)2.33715252
171negative regulation of telomere maintenance (GO:0032205)2.32518455
172regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.32176300
173regulation of mitotic spindle checkpoint (GO:1903504)2.32176300
174superoxide metabolic process (GO:0006801)2.31911620
175pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31704105
176maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31349368
177deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.30916491
178negative regulation of phagocytosis (GO:0050765)2.30718230
179positive regulation by symbiont of host defense response (GO:0052509)2.30516991
180modulation by symbiont of host defense response (GO:0052031)2.30516991
181modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30516991
182modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30516991
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.30516991
184modulation by symbiont of host immune response (GO:0052553)2.30516991
185telomere maintenance via semi-conservative replication (GO:0032201)2.30489884
186poly(A)+ mRNA export from nucleus (GO:0016973)2.29986407
187regulation of mast cell degranulation (GO:0043304)2.29953709
188endosome to pigment granule transport (GO:0043485)2.28591498
189endosome to melanosome transport (GO:0035646)2.28591498
190respiratory burst (GO:0045730)2.28163277
191proteasome assembly (GO:0043248)2.26572684
192regulation of mast cell activation involved in immune response (GO:0033006)2.25176868
193cellular response to zinc ion (GO:0071294)2.24550804
194DNA demethylation (GO:0080111)2.24222382
195T cell lineage commitment (GO:0002360)2.23915111
196DNA ligation (GO:0006266)2.23411658
197purine deoxyribonucleotide catabolic process (GO:0009155)2.22452296
198RNA-dependent DNA replication (GO:0006278)2.21401114
199regulation of interleukin-1 beta secretion (GO:0050706)2.21145436
200histone H3-K36 demethylation (GO:0070544)2.19953803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52964393
2EZH2_22144423_ChIP-Seq_EOC_Human4.42763447
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.45223455
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.25151947
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.03325986
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.92674465
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80285237
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.73021575
9* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.68015810
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65515090
11GBX2_23144817_ChIP-Seq_PC3_Human2.64086020
12* FLI1_27457419_Chip-Seq_LIVER_Mouse2.64074938
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.35071519
14TAF15_26573619_Chip-Seq_HEK293_Human2.30742622
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21328254
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.20908586
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20594535
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12948595
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.09110158
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09110158
21* NFE2_27457419_Chip-Seq_LIVER_Mouse2.08510632
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07472627
23ZNF274_21170338_ChIP-Seq_K562_Hela2.07182518
24* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06286889
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.06269206
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05204157
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.04820339
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98286416
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98108862
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97032763
31AR_21572438_ChIP-Seq_LNCaP_Human1.95732425
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94978893
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.94721584
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92389790
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92191346
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88811809
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87792787
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85977457
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.84841166
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82980896
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81568187
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78378872
43SMAD4_21799915_ChIP-Seq_A2780_Human1.77530363
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77025876
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76332351
46EWS_26573619_Chip-Seq_HEK293_Human1.76147778
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.75908521
48* REST_18959480_ChIP-ChIP_MESCs_Mouse1.74414529
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73460815
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71716159
51* EZH2_27294783_Chip-Seq_NPCs_Mouse1.69868694
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.69515937
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67952788
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66667887
55SCL_19346495_ChIP-Seq_HPC-7_Human1.66182979
56* STAT3_18555785_Chip-Seq_ESCs_Mouse1.64713306
57IRF1_19129219_ChIP-ChIP_H3396_Human1.63035312
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60563774
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60380303
60RNF2_27304074_Chip-Seq_NSC_Mouse1.59663363
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59662146
62IGF1R_20145208_ChIP-Seq_DFB_Human1.58298800
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57802562
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.57332632
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57257593
66ELK1_19687146_ChIP-ChIP_HELA_Human1.56779488
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55694038
68* P53_22387025_ChIP-Seq_ESCs_Mouse1.55548203
69DROSHA_22980978_ChIP-Seq_HELA_Human1.55251666
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53658244
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53560373
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53230358
73* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52766487
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52365037
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52228395
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.49685776
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49460819
78* E2F1_18555785_Chip-Seq_ESCs_Mouse1.49416082
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49301405
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49039887
81* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47997595
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47424174
83* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46764566
84AR_25329375_ChIP-Seq_VCAP_Human1.45646353
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45244372
86STAT3_23295773_ChIP-Seq_U87_Human1.45031791
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.44515263
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43764728
89* NMYC_18555785_Chip-Seq_ESCs_Mouse1.43137797
90* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43013742
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42368124
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41957070
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39376692
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39376692
95* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39272519
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38045762
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.37586209
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37519868
99* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37512372
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36913793
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36797731
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36439961
103* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35759969
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35575648
105VDR_23849224_ChIP-Seq_CD4+_Human1.35375407
106* NANOG_18555785_Chip-Seq_ESCs_Mouse1.34428664
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32576873
108* ZFX_18555785_Chip-Seq_ESCs_Mouse1.31369592
109* SOX2_18555785_Chip-Seq_ESCs_Mouse1.31098864
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30633850
111* PU1_27457419_Chip-Seq_LIVER_Mouse1.29998039
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29269400
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29251191
114FUS_26573619_Chip-Seq_HEK293_Human1.29047106
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.28917553
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.28749860
117* P300_18555785_Chip-Seq_ESCs_Mouse1.28128704
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25954187
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.25506624
120* CMYC_18555785_Chip-Seq_ESCs_Mouse1.25077722
121* OCT4_18555785_Chip-Seq_ESCs_Mouse1.24879969
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24406119
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.24088926
124* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23990671
125TCF4_23295773_ChIP-Seq_U87_Human1.22476994
126ER_23166858_ChIP-Seq_MCF-7_Human1.22276873
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21331382
128BCAT_22108803_ChIP-Seq_LS180_Human1.20884211
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.20277992
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19504104
131EST1_17652178_ChIP-ChIP_JURKAT_Human1.18902301
132* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18507765
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17540958
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16070079
135* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14311079
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14209478
137* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14131571
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13987769
139* KLF4_18555785_Chip-Seq_ESCs_Mouse1.13765095
140STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13125922
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12787000
142SPI1_23547873_ChIP-Seq_NB4_Human1.12759091
143VDR_22108803_ChIP-Seq_LS180_Human1.12207253
144FOXP3_21729870_ChIP-Seq_TREG_Human1.11832628
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09659918
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09451145
147KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09428942
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08833639
149* CTCF_18555785_Chip-Seq_ESCs_Mouse1.08724817
150* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08678154
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07215871
152MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06106727
153P300_19829295_ChIP-Seq_ESCs_Human1.06096747
154BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04309669
155YY1_21170310_ChIP-Seq_MESCs_Mouse1.03914643
156BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03638018
157* TCF4_22108803_ChIP-Seq_LS180_Human1.03614389
158* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03122837
159E2F1_21310950_ChIP-Seq_MCF-7_Human1.00681778
160SOX9_26525672_Chip-Seq_HEART_Mouse1.00370306
161* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99989082
162TP53_22573176_ChIP-Seq_HFKS_Human0.99959904
163TAL1_26923725_Chip-Seq_HPCs_Mouse0.99929854
164POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99923914
165IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99720534
166CBP_20019798_ChIP-Seq_JUKART_Human0.99720534
167ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98194568
168* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98041021
169FOXM1_23109430_ChIP-Seq_U2OS_Human0.97834439
170FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97533140
171CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97290757
172OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96960160
173EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95481520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.29559485
2MP0002822_catalepsy4.02356260
3MP0001188_hyperpigmentation3.55654251
4MP0006292_abnormal_olfactory_placode3.47781859
5MP0000566_synostosis3.43388106
6MP0001835_abnormal_antigen_presentation3.04953344
7MP0000778_abnormal_nervous_system2.82805430
8MP0006276_abnormal_autonomic_nervous2.82150872
9MP0008058_abnormal_DNA_repair2.70564887
10MP0009697_abnormal_copulation2.69722752
11MP0002909_abnormal_adrenal_gland2.64254989
12MP0002132_abnormal_respiratory_system2.58688989
13MP0005171_absent_coat_pigmentation2.37997896
14MP0002148_abnormal_hypersensitivity_rea2.35843973
15MP0000015_abnormal_ear_pigmentation2.35721757
16MP0002653_abnormal_ependyma_morphology2.33222141
17MP0002102_abnormal_ear_morphology2.26631158
18MP0008007_abnormal_cellular_replicative2.26046703
19MP0001529_abnormal_vocalization2.25155942
20MP0009785_altered_susceptibility_to2.20077224
21MP0003941_abnormal_skin_development2.18686254
22MP0004270_analgesia2.18100872
23MP0006072_abnormal_retinal_apoptosis2.17077001
24MP0002396_abnormal_hematopoietic_system2.10839410
25MP0010094_abnormal_chromosome_stability2.10460037
26MP0004859_abnormal_synaptic_plasticity2.08615568
27MP0002277_abnormal_respiratory_mucosa2.04623007
28MP0003136_yellow_coat_color2.03073108
29MP0008057_abnormal_DNA_replication2.01670363
30MP0003111_abnormal_nucleus_morphology2.00024412
31MP0003329_amyloid_beta_deposits1.93999019
32MP0003635_abnormal_synaptic_transmissio1.90423263
33MP0005174_abnormal_tail_pigmentation1.87502752
34MP0005423_abnormal_somatic_nervous1.86603141
35MP0004133_heterotaxia1.83657823
36MP0002734_abnormal_mechanical_nocicepti1.82736695
37MP0008789_abnormal_olfactory_epithelium1.82095417
38MP0005075_abnormal_melanosome_morpholog1.80904264
39MP0004782_abnormal_surfactant_physiolog1.80267954
40MP0009745_abnormal_behavioral_response1.80123279
41* MP0005253_abnormal_eye_physiology1.76566709
42MP0002272_abnormal_nervous_system1.74431308
43MP0001486_abnormal_startle_reflex1.71954814
44MP0000579_abnormal_nail_morphology1.70396328
45MP0000372_irregular_coat_pigmentation1.69164405
46MP0005646_abnormal_pituitary_gland1.68986511
47MP0001905_abnormal_dopamine_level1.66677244
48MP0001970_abnormal_pain_threshold1.65698503
49MP0002572_abnormal_emotion/affect_behav1.65357346
50MP0002557_abnormal_social/conspecific_i1.64974131
51MP0002419_abnormal_innate_immunity1.64005897
52MP0002063_abnormal_learning/memory/cond1.61588345
53MP0004885_abnormal_endolymph1.61226498
54MP0005671_abnormal_response_to1.60864164
55MP0003283_abnormal_digestive_organ1.58584769
56MP0002064_seizures1.58430263
57MP0003787_abnormal_imprinting1.57522715
58MP0005499_abnormal_olfactory_system1.56156242
59MP0005394_taste/olfaction_phenotype1.56156242
60MP0002736_abnormal_nociception_after1.53144837
61MP0000490_abnormal_crypts_of1.47134487
62MP0002452_abnormal_antigen_presenting1.45551527
63MP0003693_abnormal_embryo_hatching1.44997324
64MP0009046_muscle_twitch1.43742764
65MP0001968_abnormal_touch/_nociception1.43655014
66MP0005025_abnormal_response_to1.43509107
67MP0000955_abnormal_spinal_cord1.42630092
68* MP0002882_abnormal_neuron_morphology1.42593756
69MP0002184_abnormal_innervation1.42002257
70MP0005387_immune_system_phenotype1.41242908
71MP0001790_abnormal_immune_system1.41242908
72MP0000538_abnormal_urinary_bladder1.38423348
73MP0002928_abnormal_bile_duct1.38335365
74MP0003786_premature_aging1.38247800
75MP0005000_abnormal_immune_tolerance1.38230622
76MP0003077_abnormal_cell_cycle1.38172188
77MP0003122_maternal_imprinting1.37066851
78MP0002067_abnormal_sensory_capabilities1.36736474
79MP0002735_abnormal_chemical_nociception1.31745127
80MP0002095_abnormal_skin_pigmentation1.31409592
81MP0004811_abnormal_neuron_physiology1.30568643
82MP0001545_abnormal_hematopoietic_system1.30547365
83MP0005397_hematopoietic_system_phenotyp1.30547365
84MP0008877_abnormal_DNA_methylation1.29545022
85MP0002938_white_spotting1.29267583
86MP0001819_abnormal_immune_cell1.28577237
87MP0003436_decreased_susceptibility_to1.28207834
88* MP0002752_abnormal_somatic_nervous1.27033648
89MP0002420_abnormal_adaptive_immunity1.26483970
90MP0001800_abnormal_humoral_immune1.25458736
91MP0002876_abnormal_thyroid_physiology1.25216296
92MP0002723_abnormal_immune_serum1.24914365
93MP0002733_abnormal_thermal_nociception1.24643977
94MP0004147_increased_porphyrin_level1.22919544
95MP0005248_abnormal_Harderian_gland1.22743995
96MP0000371_diluted_coat_color1.22443834
97MP0009053_abnormal_anal_canal1.20706792
98MP0000569_abnormal_digit_pigmentation1.20666719
99MP0004381_abnormal_hair_follicle1.19081601
100MP0008260_abnormal_autophagy1.18281848
101MP0000383_abnormal_hair_follicle1.15522319
102MP0010386_abnormal_urinary_bladder1.15402204
103MP0001293_anophthalmia1.15176121
104MP0001986_abnormal_taste_sensitivity1.15063694
105MP0002163_abnormal_gland_morphology1.14822064
106MP0001186_pigmentation_phenotype1.14090801
107MP0003632_abnormal_nervous_system1.13518753
108MP0002234_abnormal_pharynx_morphology1.13005054
109MP0004142_abnormal_muscle_tone1.12160067
110MP0005386_behavior/neurological_phenoty1.11946948
111MP0004924_abnormal_behavior1.11946948
112MP0003763_abnormal_thymus_physiology1.11644382
113* MP0005391_vision/eye_phenotype1.10046726
114MP0000631_abnormal_neuroendocrine_gland1.09909024
115MP0010030_abnormal_orbit_morphology1.08689712
116MP0004808_abnormal_hematopoietic_stem1.08410237
117MP0003633_abnormal_nervous_system1.08095812
118* MP0005195_abnormal_posterior_eye1.07248814
119* MP0002152_abnormal_brain_morphology1.06786669
120MP0001984_abnormal_olfaction1.06621418
121MP0001485_abnormal_pinna_reflex1.06294068
122MP0002398_abnormal_bone_marrow1.04427598
123MP0000026_abnormal_inner_ear1.03801235
124MP0002090_abnormal_vision1.02779915
125MP0002075_abnormal_coat/hair_pigmentati1.02398291
126MP0005645_abnormal_hypothalamus_physiol1.01149941
127* MP0002638_abnormal_pupillary_reflex1.00817515
128MP0000647_abnormal_sebaceous_gland1.00384542
129MP0002160_abnormal_reproductive_system1.00058115
130MP0009764_decreased_sensitivity_to0.99994296
131MP0005367_renal/urinary_system_phenotyp0.99217016
132MP0000516_abnormal_urinary_system0.99217016
133MP0003631_nervous_system_phenotype0.93248444
134MP0001119_abnormal_female_reproductive0.92987460
135MP0005464_abnormal_platelet_physiology0.92505332
136* MP0001502_abnormal_circadian_rhythm0.92143655
137MP0003183_abnormal_peptide_metabolism0.91610830
138MP0003186_abnormal_redox_activity0.91600734
139MP0005409_darkened_coat_color0.91593110
140MP0005187_abnormal_penis_morphology0.90614835
141MP0000716_abnormal_immune_system0.90237231
142MP0000685_abnormal_immune_system0.89222837
143MP0003861_abnormal_nervous_system0.88433878
144MP0008995_early_reproductive_senescence0.87756686
145MP0000604_amyloidosis0.87419170
146MP0010155_abnormal_intestine_physiology0.87257545
147MP0001853_heart_inflammation0.87135096
148MP0004742_abnormal_vestibular_system0.85462878
149MP0004043_abnormal_pH_regulation0.84297367
150MP0001963_abnormal_hearing_physiology0.84178721
151MP0002066_abnormal_motor_capabilities/c0.83989171
152MP0001177_atelectasis0.83823147
153MP0003121_genomic_imprinting0.83321750
154MP0000678_abnormal_parathyroid_gland0.82825058
155MP0003119_abnormal_digestive_system0.82498345
156MP0000427_abnormal_hair_cycle0.81788513
157MP0000681_abnormal_thyroid_gland0.81765889
158MP0002405_respiratory_system_inflammati0.81558090
159MP0003890_abnormal_embryonic-extraembry0.81204811
160MP0002249_abnormal_larynx_morphology0.78539832
161MP0008004_abnormal_stomach_pH0.78534814
162* MP0002229_neurodegeneration0.78514591
163* MP0005551_abnormal_eye_electrophysiolog0.78408377
164MP0002429_abnormal_blood_cell0.78357568
165MP0003828_pulmonary_edema0.76133626
166MP0000013_abnormal_adipose_tissue0.76013910
167MP0002006_tumorigenesis0.74798300
168MP0000689_abnormal_spleen_morphology0.74735394
169MP0003724_increased_susceptibility_to0.74365473
170MP0002722_abnormal_immune_system0.73952226
171MP0001324_abnormal_eye_pigmentation0.73878259
172MP0002751_abnormal_autonomic_nervous0.73338477
173MP0009333_abnormal_splenocyte_physiolog0.73294961
174MP0000858_altered_metastatic_potential0.71398655
175MP0003011_delayed_dark_adaptation0.71270156
176MP0001845_abnormal_inflammatory_respons0.70494947
177MP0005257_abnormal_intraocular_pressure0.69537095
178MP0001346_abnormal_lacrimal_gland0.69082273

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.34039387
2Chromsome breakage (HP:0040012)5.18581046
3Retrobulbar optic neuritis (HP:0100654)4.46861639
4Optic neuritis (HP:0100653)4.46861639
5Orchitis (HP:0100796)3.63433156
6Myositis (HP:0100614)3.34943918
7Hemiparesis (HP:0001269)3.28528022
8Focal seizures (HP:0007359)3.25506982
9Prostate neoplasm (HP:0100787)3.23858085
10Molar tooth sign on MRI (HP:0002419)3.22283670
11Abnormality of midbrain morphology (HP:0002418)3.22283670
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17601142
13Abnormality of the renal collecting system (HP:0004742)3.10296530
14Nephronophthisis (HP:0000090)3.09447609
15Abnormality of the preputium (HP:0100587)2.98457187
16Abnormality of DNA repair (HP:0003254)2.98054022
17Duplicated collecting system (HP:0000081)2.94784409
18Clubbing of toes (HP:0100760)2.93322526
19Polyphagia (HP:0002591)2.92558517
20Abnormal respiratory motile cilium physiology (HP:0012261)2.87396844
21Abnormal ciliary motility (HP:0012262)2.85755966
22Occipital encephalocele (HP:0002085)2.82401923
23Amyotrophic lateral sclerosis (HP:0007354)2.79428217
24Renal cortical cysts (HP:0000803)2.79407110
25Abnormal respiratory epithelium morphology (HP:0012253)2.78832465
26Abnormal respiratory motile cilium morphology (HP:0005938)2.78832465
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.76871642
28Abnormality of chromosome stability (HP:0003220)2.75449381
29Myokymia (HP:0002411)2.75088764
30Abnormality of the renal medulla (HP:0100957)2.73759728
31Keratoconjunctivitis sicca (HP:0001097)2.73631267
32Genital tract atresia (HP:0001827)2.70683464
33Recurrent abscess formation (HP:0002722)2.69333139
34Meckel diverticulum (HP:0002245)2.68921858
35Cystic liver disease (HP:0006706)2.67365392
36Hyperventilation (HP:0002883)2.67261113
37True hermaphroditism (HP:0010459)2.66726340
38Ulnar claw (HP:0001178)2.66420209
39Generalized tonic-clonic seizures (HP:0002069)2.64109497
40Agitation (HP:0000713)2.63953798
41Abnormality of the ileum (HP:0001549)2.62690415
42Type I transferrin isoform profile (HP:0003642)2.59283434
43Status epilepticus (HP:0002133)2.59122262
44Dyschromatopsia (HP:0007641)2.57874096
45Rhinitis (HP:0012384)2.56752663
46Drooling (HP:0002307)2.56499455
47Vaginal atresia (HP:0000148)2.54300208
48Keratoconjunctivitis (HP:0001096)2.53800904
49Mediastinal lymphadenopathy (HP:0100721)2.52464710
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.52114260
51Broad foot (HP:0001769)2.51606147
52Renal hypoplasia (HP:0000089)2.48419744
53Congenital stationary night blindness (HP:0007642)2.48276751
54Focal motor seizures (HP:0011153)2.46765148
55Intestinal atresia (HP:0011100)2.45211833
56Neonatal respiratory distress (HP:0002643)2.41307234
57Pheochromocytoma (HP:0002666)2.40931611
58Abnormality of the prostate (HP:0008775)2.38730721
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.37748366
60Hypoplasia of the fovea (HP:0007750)2.37748366
61Spinal cord lesions (HP:0100561)2.35034733
62Syringomyelia (HP:0003396)2.35034733
63Aplastic anemia (HP:0001915)2.34378240
64White forelock (HP:0002211)2.34371310
65Stomach cancer (HP:0012126)2.32374444
66Excessive salivation (HP:0003781)2.32114042
67Duplication of thumb phalanx (HP:0009942)2.29545692
68Septo-optic dysplasia (HP:0100842)2.29233850
69Alveolar cell carcinoma (HP:0006519)2.28077651
70Amblyopia (HP:0000646)2.27842249
71Cortical dysplasia (HP:0002539)2.27402100
72Absent speech (HP:0001344)2.27121660
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27085962
74Bony spicule pigmentary retinopathy (HP:0007737)2.25784551
75Pancreatic fibrosis (HP:0100732)2.25002127
76Spastic tetraparesis (HP:0001285)2.24176287
77Hyperglycinemia (HP:0002154)2.22683084
78Birth length less than 3rd percentile (HP:0003561)2.21917174
79Methylmalonic acidemia (HP:0002912)2.21626939
80Epileptic encephalopathy (HP:0200134)2.21039446
81Atonic seizures (HP:0010819)2.19764320
82Congenital, generalized hypertrichosis (HP:0004540)2.19261216
83Patchy hypopigmentation of hair (HP:0011365)2.18501773
84Abnormality of the lower motor neuron (HP:0002366)2.18093044
85Specific learning disability (HP:0001328)2.17648378
86Anencephaly (HP:0002323)2.17020901
87Postaxial hand polydactyly (HP:0001162)2.16881497
88Abolished electroretinogram (ERG) (HP:0000550)2.16052339
89Recurrent bacterial skin infections (HP:0005406)2.15796372
90Split foot (HP:0001839)2.15785834
91Nephrogenic diabetes insipidus (HP:0009806)2.14114486
92Ectopic kidney (HP:0000086)2.13985643
93Bone marrow hypocellularity (HP:0005528)2.12710903
94Polydipsia (HP:0001959)2.12205153
95Abnormal drinking behavior (HP:0030082)2.12205153
96Albinism (HP:0001022)2.12006808
97Supernumerary spleens (HP:0009799)2.10592512
98Sclerocornea (HP:0000647)2.09780733
99Medial flaring of the eyebrow (HP:0010747)2.09602213
100Neuroendocrine neoplasm (HP:0100634)2.08725761
101Preaxial hand polydactyly (HP:0001177)2.07264558
102Myelodysplasia (HP:0002863)2.06063205
103Osteomalacia (HP:0002749)2.06009735
104Type 2 muscle fiber atrophy (HP:0003554)2.05627988
105Pulmonary infiltrates (HP:0002113)2.05536428
106Retinal dysplasia (HP:0007973)2.04525897
107Generalized myoclonic seizures (HP:0002123)2.04165582
108Small intestinal stenosis (HP:0012848)2.03482360
109Duodenal stenosis (HP:0100867)2.03482360
110Glomerulopathy (HP:0100820)2.02458372
111Optic nerve hypoplasia (HP:0000609)2.02106572
112Methylmalonic aciduria (HP:0012120)2.01470462
113Congenital primary aphakia (HP:0007707)2.01431060
114Peripheral hypomyelination (HP:0007182)2.01397733
115Coronal craniosynostosis (HP:0004440)2.01391420
116EEG with generalized epileptiform discharges (HP:0011198)2.01083701
117Hemiplegia (HP:0002301)2.00525821
118Epileptiform EEG discharges (HP:0011182)1.99614571
119Rib fusion (HP:0000902)1.99467019
120Concave nail (HP:0001598)1.99064917
121Elevated erythrocyte sedimentation rate (HP:0003565)1.99008894
122Hypsarrhythmia (HP:0002521)1.98933072
123Recurrent pneumonia (HP:0006532)1.98893987
124Abnormality of incisor morphology (HP:0011063)1.98329457
125Reduced antithrombin III activity (HP:0001976)1.98066211
126Agnosia (HP:0010524)1.96879100
127Abnormal biliary tract physiology (HP:0012439)1.94097529
128Bile duct proliferation (HP:0001408)1.94097529
129Abnormal eating behavior (HP:0100738)1.93836838
130Chronic obstructive pulmonary disease (HP:0006510)1.93061168
131Obstructive lung disease (HP:0006536)1.93061168
132Anterior segment dysgenesis (HP:0007700)1.92767753
133Tubulointerstitial abnormality (HP:0001969)1.92584313
134Postaxial foot polydactyly (HP:0001830)1.91591013
135Dialeptic seizures (HP:0011146)1.91570913
136Xerostomia (HP:0000217)1.91552161
137Abnormal rod and cone electroretinograms (HP:0008323)1.91406059
138Narrow forehead (HP:0000341)1.90784393
139Eczematoid dermatitis (HP:0000976)1.90717036
140Hypothermia (HP:0002045)1.90477690
141Neoplasm of the adrenal cortex (HP:0100641)1.90390259
142Chorioretinal atrophy (HP:0000533)1.90369489
143Abnormality of macular pigmentation (HP:0008002)1.89814456
144Tubular atrophy (HP:0000092)1.89781658
145Febrile seizures (HP:0002373)1.89523703
146Tubulointerstitial fibrosis (HP:0005576)1.87581699
147Oligodactyly (hands) (HP:0001180)1.86867171
148Optic nerve coloboma (HP:0000588)1.86416444
149Pancreatic cysts (HP:0001737)1.86407314
150Microvesicular hepatic steatosis (HP:0001414)1.86108678
151Keratitis (HP:0000491)1.85298490
152Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85117181
153Hypoplasia of the brainstem (HP:0002365)1.85117181
154Absence seizures (HP:0002121)1.84351718
155Vasculitis (HP:0002633)1.83393270
156Polymicrogyria (HP:0002126)1.83289829
157Gait imbalance (HP:0002141)1.82571858
158Poor coordination (HP:0002370)1.82321933
159Neoplasm of the tracheobronchial system (HP:0100552)1.82175017
160Abnormality of the carotid arteries (HP:0005344)1.82102265
161Petechiae (HP:0000967)1.81936925
162Follicular hyperkeratosis (HP:0007502)1.80953175
163Megalencephaly (HP:0001355)1.79187635
164Large for gestational age (HP:0001520)1.78488940
165Cutaneous finger syndactyly (HP:0010554)1.78033532
166Congenital sensorineural hearing impairment (HP:0008527)1.77809385
167Tubulointerstitial nephritis (HP:0001970)1.77546740
168Abnormality of the fovea (HP:0000493)1.75349210
169Attenuation of retinal blood vessels (HP:0007843)1.74934965
170Distal lower limb muscle weakness (HP:0009053)1.74926894
171Encephalitis (HP:0002383)1.73102967
1723-Methylglutaconic aciduria (HP:0003535)1.72104752
173Chronic hepatic failure (HP:0100626)1.70818929
174Meningitis (HP:0001287)1.70229741
175Astigmatism (HP:0000483)1.70210322
176Congenital hepatic fibrosis (HP:0002612)1.70168550
177Decreased central vision (HP:0007663)1.67361351
178Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63961644
179Increased IgM level (HP:0003496)1.63558141
180Aseptic necrosis (HP:0010885)1.63008729
181Abnormal hair whorl (HP:0010721)1.62935618
182Prolonged neonatal jaundice (HP:0006579)1.61191719
183Abnormality of the columella (HP:0009929)1.58976508
184Abnormality of the renal cortex (HP:0011035)1.58225236
185Muscle fiber atrophy (HP:0100295)1.58012517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.58493791
2ZAK3.85586796
3MAP3K143.23930282
4MAP3K43.12474464
5MAP4K22.97205490
6TXK2.85471733
7IRAK32.64687934
8NTRK22.64257467
9IRAK42.45676553
10AKT32.34579248
11DYRK22.31121461
12PDK22.26292680
13CASK2.24112507
14BCR2.19103168
15BMPR22.17417115
16NTRK32.15214659
17TRIM282.12023880
18PIK3CG2.11239463
19SRPK12.07625505
20YES12.06145941
21ERBB32.02275204
22SIK32.01759471
23EIF2AK21.99697948
24SGK21.79004251
25ADRBK21.72151555
26MAPK151.68971616
27MKNK21.65579448
28TEC1.62701630
29PRPF4B1.61580708
30BUB11.59882031
31BRD41.59821752
32PNCK1.59774110
33PLK41.58487295
34EIF2AK11.57499958
35WNK31.54961618
36IKBKB1.54638568
37PIM21.54410098
38MKNK11.48107236
39UHMK11.47599411
40STK38L1.44097692
41EPHA41.43996160
42CSNK1G31.39184402
43TNIK1.35159662
44CSNK1G21.35063208
45GRK11.34933592
46NEK91.30221153
47CDK81.29903387
48CSNK1G11.26414411
49CHUK1.23624192
50VRK11.22415725
51IKBKE1.20639025
52JAK31.20505446
53CLK11.19051330
54PINK11.17583177
55DYRK1B1.17142481
56PASK1.16317666
57ATR1.15959826
58STK161.13730284
59MAP3K121.12728808
60PAK31.12223730
61MUSK1.08954958
62DYRK1A1.07467821
63MINK11.07219973
64KIT1.03273382
65PIM11.01342588
66FLT31.00726321
67PBK0.99245321
68BTK0.97894918
69TIE10.97183365
70SGK30.96441237
71INSRR0.95953252
72FRK0.95651190
73BMPR1B0.94173658
74PHKG20.93835997
75PHKG10.93835997
76TRPM70.92302264
77GRK70.90876749
78EPHB10.90474819
79NEK60.90200078
80EPHB20.89244879
81NLK0.88205703
82FGFR20.88203064
83PRKCG0.87929903
84TAOK20.86673245
85PKN10.86527109
86SGK2230.86111814
87SGK4940.86111814
88CDK50.85332862
89EIF2AK30.84573594
90CDK30.84160156
91NME20.82229863
92MAP2K70.80959879
93TSSK60.80653963
94EPHA30.78921132
95TLK10.78698669
96DAPK20.78469367
97PLK20.78131810
98STK40.78023884
99ACVR1B0.77828501
100PRKCE0.76692271
101TTK0.76169896
102PLK10.75531157
103CSNK1A1L0.75188991
104MAP2K40.73607137
105RPS6KB10.72748568
106STK240.71450375
107RPS6KA40.71114822
108CAMK2A0.69038869
109FGFR30.68580597
110LYN0.67980579
111RIPK40.66888093
112TGFBR10.66833321
113WNK40.66720139
114BRAF0.66386308
115TBK10.64965185
116MAPK130.64660874
117PRKAA10.63692689
118NTRK10.63539397
119EPHA20.62339212
120PRKD30.61408780
121PLK30.61222714
122RPS6KA60.59872257
123SYK0.59723995
124MYLK0.59022045
125ERBB20.58820996
126CAMK2G0.58114785
127RPS6KA50.57984191
128IRAK10.57562706
129TYK20.55912495
130MAP2K60.54732814
131DYRK30.54324284
132TNK20.53082876
133CHEK20.53050648
134CDK70.52760016
135CAMK2B0.52603100
136PRKACA0.52512260
137PTK2B0.52331406
138BLK0.52230501
139RPS6KL10.51892603
140RPS6KC10.51892603
141NUAK10.51199385
142CSNK1D0.50522053
143CDK140.49567822
144STK390.48125286
145ADRBK10.47684844
146MARK20.47556116
147OBSCN0.45825275
148KSR10.45806222
149PRKCZ0.42358365
150PRKG10.41845633
151CAMK40.41447189
152CDK180.41297639
153TYRO30.40554216
154AURKB0.40157894
155PRKG20.40037368
156ATM0.39552240
157CDC70.39482906
158PRKCD0.38920690
159MAPKAPK50.38448266
160MAPK40.38092279
161WEE10.37814806
162CSNK1A10.37677094
163PRKACB0.35849139
164CDK150.34884140
165PIK3CA0.33966037
166CAMK10.33164876
167NME10.31794472
168GSK3A0.30497092
169CDK11A0.29257352
170PRKCH0.28830763

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59314338
2Base excision repair_Homo sapiens_hsa034103.01132266
3Fanconi anemia pathway_Homo sapiens_hsa034602.94272171
4Nicotine addiction_Homo sapiens_hsa050332.90289803
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.82235529
6Homologous recombination_Homo sapiens_hsa034402.75126110
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.55445546
8Mismatch repair_Homo sapiens_hsa034302.54171976
9DNA replication_Homo sapiens_hsa030302.51429793
10Butanoate metabolism_Homo sapiens_hsa006502.46253785
11Cocaine addiction_Homo sapiens_hsa050302.04835297
12Insulin secretion_Homo sapiens_hsa049112.03685024
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.99937581
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95345269
15Legionellosis_Homo sapiens_hsa051341.93495594
16Graft-versus-host disease_Homo sapiens_hsa053321.92617124
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90729807
18beta-Alanine metabolism_Homo sapiens_hsa004101.89615283
19Allograft rejection_Homo sapiens_hsa053301.88197451
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87605690
21Non-homologous end-joining_Homo sapiens_hsa034501.87298044
22Nucleotide excision repair_Homo sapiens_hsa034201.86652032
23RNA polymerase_Homo sapiens_hsa030201.84759407
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.81046453
25Basal transcription factors_Homo sapiens_hsa030221.79310751
26Synaptic vesicle cycle_Homo sapiens_hsa047211.78073918
27Phototransduction_Homo sapiens_hsa047441.77005420
28GABAergic synapse_Homo sapiens_hsa047271.76500600
29Glutamatergic synapse_Homo sapiens_hsa047241.75336062
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74433169
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72107603
32Measles_Homo sapiens_hsa051621.69088316
33RNA degradation_Homo sapiens_hsa030181.68108453
34Histidine metabolism_Homo sapiens_hsa003401.65272514
35One carbon pool by folate_Homo sapiens_hsa006701.63066485
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62085106
37Pyrimidine metabolism_Homo sapiens_hsa002401.61084059
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60947211
39Tryptophan metabolism_Homo sapiens_hsa003801.60065675
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59770240
41Circadian entrainment_Homo sapiens_hsa047131.59523769
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58501603
43Proteasome_Homo sapiens_hsa030501.56622662
44Cholinergic synapse_Homo sapiens_hsa047251.53302715
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51922694
46Morphine addiction_Homo sapiens_hsa050321.50522882
47Dopaminergic synapse_Homo sapiens_hsa047281.49134620
48Circadian rhythm_Homo sapiens_hsa047101.47707847
49Herpes simplex infection_Homo sapiens_hsa051681.47506469
50Autoimmune thyroid disease_Homo sapiens_hsa053201.46444777
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43949573
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43558827
53Lysine degradation_Homo sapiens_hsa003101.41349465
54Oxidative phosphorylation_Homo sapiens_hsa001901.40634630
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40542360
56Glycerolipid metabolism_Homo sapiens_hsa005611.35196834
57ABC transporters_Homo sapiens_hsa020101.34181961
58Spliceosome_Homo sapiens_hsa030401.33838145
59Collecting duct acid secretion_Homo sapiens_hsa049661.33187801
60Leishmaniasis_Homo sapiens_hsa051401.32768304
61Purine metabolism_Homo sapiens_hsa002301.30767114
62Cardiac muscle contraction_Homo sapiens_hsa042601.29787914
63Propanoate metabolism_Homo sapiens_hsa006401.29538980
64Hematopoietic cell lineage_Homo sapiens_hsa046401.29389036
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29257899
66Influenza A_Homo sapiens_hsa051641.28204108
67Hedgehog signaling pathway_Homo sapiens_hsa043401.27888159
68Parkinsons disease_Homo sapiens_hsa050121.26117983
69Axon guidance_Homo sapiens_hsa043601.25021158
70Amphetamine addiction_Homo sapiens_hsa050311.24008251
71p53 signaling pathway_Homo sapiens_hsa041151.22767008
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21603268
73Asthma_Homo sapiens_hsa053101.21267856
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20380989
75Cell cycle_Homo sapiens_hsa041101.18117033
76Arachidonic acid metabolism_Homo sapiens_hsa005901.16345910
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15917674
78Rheumatoid arthritis_Homo sapiens_hsa053231.15034893
79Type I diabetes mellitus_Homo sapiens_hsa049401.13649408
80Basal cell carcinoma_Homo sapiens_hsa052171.13332704
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12395725
82Taste transduction_Homo sapiens_hsa047421.11640800
83Fatty acid metabolism_Homo sapiens_hsa012121.11283956
84Fatty acid degradation_Homo sapiens_hsa000711.10058816
85Steroid biosynthesis_Homo sapiens_hsa001001.09283856
86Fatty acid elongation_Homo sapiens_hsa000621.07891049
87Nitrogen metabolism_Homo sapiens_hsa009101.07801518
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05225370
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03335248
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02484122
91TNF signaling pathway_Homo sapiens_hsa046681.00729192
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.97729949
93Arginine and proline metabolism_Homo sapiens_hsa003300.97592185
94Other glycan degradation_Homo sapiens_hsa005110.95921602
95Primary immunodeficiency_Homo sapiens_hsa053400.94744858
96Linoleic acid metabolism_Homo sapiens_hsa005910.93007285
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92933304
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92583038
99Apoptosis_Homo sapiens_hsa042100.91899754
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90817864
101Salivary secretion_Homo sapiens_hsa049700.89771187
102* Olfactory transduction_Homo sapiens_hsa047400.89456225
103Gap junction_Homo sapiens_hsa045400.89433839
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89107728
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87948351
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86875042
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.85999247
108Long-term depression_Homo sapiens_hsa047300.84519179
109Epstein-Barr virus infection_Homo sapiens_hsa051690.81479665
110RNA transport_Homo sapiens_hsa030130.81214668
111Thyroid hormone synthesis_Homo sapiens_hsa049180.81002479
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76718018
113Hepatitis B_Homo sapiens_hsa051610.75409305
114Pertussis_Homo sapiens_hsa051330.74891814
115Bile secretion_Homo sapiens_hsa049760.74540563
116Gastric acid secretion_Homo sapiens_hsa049710.74375925
117Type II diabetes mellitus_Homo sapiens_hsa049300.73166956
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72854964
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.72150679
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70318748
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68681388
122Alcoholism_Homo sapiens_hsa050340.68063492
123Alzheimers disease_Homo sapiens_hsa050100.67112913
124* cAMP signaling pathway_Homo sapiens_hsa040240.67010918
125Osteoclast differentiation_Homo sapiens_hsa043800.66614206
126Tuberculosis_Homo sapiens_hsa051520.66240853
127mRNA surveillance pathway_Homo sapiens_hsa030150.65368155
128Fatty acid biosynthesis_Homo sapiens_hsa000610.64276635
129Malaria_Homo sapiens_hsa051440.64196410
130Peroxisome_Homo sapiens_hsa041460.63564005
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62099804
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61912160
133Vitamin digestion and absorption_Homo sapiens_hsa049770.61539961
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61095597
135Phagosome_Homo sapiens_hsa041450.60256723
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56425379
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55612401
138Chemokine signaling pathway_Homo sapiens_hsa040620.55035316
139Selenocompound metabolism_Homo sapiens_hsa004500.54769440
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53309380
141Choline metabolism in cancer_Homo sapiens_hsa052310.51795396
142Pancreatic secretion_Homo sapiens_hsa049720.51627597
143Acute myeloid leukemia_Homo sapiens_hsa052210.50062025
144Salmonella infection_Homo sapiens_hsa051320.49193970
145HTLV-I infection_Homo sapiens_hsa051660.49067119
146Ovarian steroidogenesis_Homo sapiens_hsa049130.48659715
147Calcium signaling pathway_Homo sapiens_hsa040200.48500402
148PPAR signaling pathway_Homo sapiens_hsa033200.48374939
149African trypanosomiasis_Homo sapiens_hsa051430.47782794
150Melanogenesis_Homo sapiens_hsa049160.47618970
151Pyruvate metabolism_Homo sapiens_hsa006200.46915630
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46899472
153Ribosome_Homo sapiens_hsa030100.46259219
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45441814
155Dorso-ventral axis formation_Homo sapiens_hsa043200.45143191
156Chemical carcinogenesis_Homo sapiens_hsa052040.44687917
157Vibrio cholerae infection_Homo sapiens_hsa051100.44686687
158Renin secretion_Homo sapiens_hsa049240.44361030
159Toxoplasmosis_Homo sapiens_hsa051450.44011238
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43521334
161Protein export_Homo sapiens_hsa030600.42871707
162Estrogen signaling pathway_Homo sapiens_hsa049150.42087287
163Hippo signaling pathway_Homo sapiens_hsa043900.41907382
164Melanoma_Homo sapiens_hsa052180.41589932
165Oxytocin signaling pathway_Homo sapiens_hsa049210.41334391
166Shigellosis_Homo sapiens_hsa051310.40439964
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40272459
168Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39896476
169Hepatitis C_Homo sapiens_hsa051600.39264430
170Systemic lupus erythematosus_Homo sapiens_hsa053220.39027374
171Glycosaminoglycan degradation_Homo sapiens_hsa005310.37873068
172Notch signaling pathway_Homo sapiens_hsa043300.37187528
173Regulation of autophagy_Homo sapiens_hsa041400.36072268
174B cell receptor signaling pathway_Homo sapiens_hsa046620.35190993
175Sphingolipid metabolism_Homo sapiens_hsa006000.34883090
176Ether lipid metabolism_Homo sapiens_hsa005650.33758893
177Antigen processing and presentation_Homo sapiens_hsa046120.33566971
178Viral carcinogenesis_Homo sapiens_hsa052030.32989025
179Prostate cancer_Homo sapiens_hsa052150.28604025
180Huntingtons disease_Homo sapiens_hsa050160.26930867
181Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26498746
182Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26202053
183Retinol metabolism_Homo sapiens_hsa008300.24635005
184Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24203763
185FoxO signaling pathway_Homo sapiens_hsa040680.23442104
186Serotonergic synapse_Homo sapiens_hsa047260.23115401
187Viral myocarditis_Homo sapiens_hsa054160.23045683

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