CNGA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)9.60876248
2left/right pattern formation (GO:0060972)9.26246144
3protein polyglutamylation (GO:0018095)8.24844303
4regulation of female gonad development (GO:2000194)8.05474288
5primary alcohol catabolic process (GO:0034310)7.33762751
6regulation of cilium movement (GO:0003352)7.24695952
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.03807744
8vitamin transmembrane transport (GO:0035461)6.98745957
9negative regulation of cytosolic calcium ion concentration (GO:0051481)6.40789152
10ethanol metabolic process (GO:0006067)6.10469733
11cilium organization (GO:0044782)5.99811011
12activation of protein kinase A activity (GO:0034199)5.83551791
13response to xenobiotic stimulus (GO:0009410)5.75095164
14microtubule severing (GO:0051013)5.62633564
15axonemal dynein complex assembly (GO:0070286)5.57671733
16centriole assembly (GO:0098534)5.55153511
17diterpenoid biosynthetic process (GO:0016102)5.53253702
18tolerance induction (GO:0002507)5.29414305
19pyrimidine-containing compound transmembrane transport (GO:0072531)5.27614714
20regulation of interleukin-5 production (GO:0032674)5.26277605
21intraciliary transport (GO:0042073)5.15401815
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.10709807
23cAMP biosynthetic process (GO:0006171)5.06448912
24cilium movement (GO:0003341)5.00204830
25behavioral response to cocaine (GO:0048148)4.95014422
26dopamine receptor signaling pathway (GO:0007212)4.86143236
27microtubule-based movement (GO:0007018)4.85637215
28lung epithelium development (GO:0060428)4.78359645
29cilium morphogenesis (GO:0060271)4.77724158
30one-carbon compound transport (GO:0019755)4.73943564
31sperm capacitation (GO:0048240)4.73508575
32establishment of apical/basal cell polarity (GO:0035089)4.71382900
33negative regulation of B cell mediated immunity (GO:0002713)4.66172548
34negative regulation of immunoglobulin mediated immune response (GO:0002890)4.66172548
35glomerular epithelial cell development (GO:0072310)4.63573839
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.63473004
37negative regulation of T cell differentiation in thymus (GO:0033085)4.62312654
38cellular component assembly involved in morphogenesis (GO:0010927)4.59951259
39regulation of interleukin-13 production (GO:0032656)4.57640506
40ethanol oxidation (GO:0006069)4.44458520
41axoneme assembly (GO:0035082)4.40702988
42regulation of microtubule-based movement (GO:0060632)4.40674191
43ventricular system development (GO:0021591)4.39161238
44negative regulation of humoral immune response (GO:0002921)4.39115251
45regulation of germinal center formation (GO:0002634)4.23682282
46cell projection assembly (GO:0030031)4.20988235
47regulation of synapse structural plasticity (GO:0051823)4.17229225
48positive regulation of tolerance induction (GO:0002645)4.15638011
49response to gravity (GO:0009629)4.07416654
50antibacterial humoral response (GO:0019731)4.06131552
51establishment of monopolar cell polarity (GO:0061162)4.05813969
52establishment or maintenance of monopolar cell polarity (GO:0061339)4.05813969
53response to caffeine (GO:0031000)4.05705483
54regulation of protein kinase A signaling (GO:0010738)3.98128965
55negative regulation of inclusion body assembly (GO:0090084)3.91308007
56retinoic acid metabolic process (GO:0042573)3.88766539
57cytoplasmic microtubule organization (GO:0031122)3.87610339
58adipose tissue development (GO:0060612)3.86937236
59microtubule depolymerization (GO:0007019)3.85012650
60regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.82800108
61regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.82800108
62cellular response to glucagon stimulus (GO:0071377)3.80573658
63terpenoid biosynthetic process (GO:0016114)3.80074414
64regulation of chromatin binding (GO:0035561)3.79033125
65neuron cell-cell adhesion (GO:0007158)3.73086219
66antimicrobial humoral response (GO:0019730)3.72281444
67lateral ventricle development (GO:0021670)3.67453495
68regulation of sodium ion transmembrane transporter activity (GO:2000649)3.67276971
69microtubule polymerization or depolymerization (GO:0031109)3.64900310
70innate immune response in mucosa (GO:0002227)3.59921299
71detection of calcium ion (GO:0005513)3.57511027
72regulation of heart rate by cardiac conduction (GO:0086091)3.47026801
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45882997
74magnesium ion transport (GO:0015693)3.42749489
75response to amphetamine (GO:0001975)3.38986486
76atrial cardiac muscle cell action potential (GO:0086014)3.34931601
77peptidyl-glutamic acid modification (GO:0018200)3.32589287
78centriole replication (GO:0007099)3.29294394
79auditory receptor cell differentiation (GO:0042491)3.28903544
80auditory behavior (GO:0031223)3.28638992
81positive regulation of insulin receptor signaling pathway (GO:0046628)3.27968854
82O-glycan processing (GO:0016266)3.27605968
83positive regulation of triglyceride biosynthetic process (GO:0010867)3.26347978
84cAMP metabolic process (GO:0046058)3.26131748
85exogenous drug catabolic process (GO:0042738)3.25616084
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25613848
87establishment of planar polarity (GO:0001736)3.23534303
88establishment of tissue polarity (GO:0007164)3.23534303
89regulation of sodium ion transmembrane transport (GO:1902305)3.19525398
90response to inactivity (GO:0014854)3.18865140
91primary alcohol metabolic process (GO:0034308)3.18717929
92left/right axis specification (GO:0070986)3.17583791
93sperm motility (GO:0030317)3.17195392
94peristalsis (GO:0030432)3.16671726
95regulation of tolerance induction (GO:0002643)3.16162579
96positive regulation of growth hormone secretion (GO:0060124)3.14736087
97glutathione derivative metabolic process (GO:1901685)3.13258468
98glutathione derivative biosynthetic process (GO:1901687)3.13258468
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.11498918
100positive regulation of smoothened signaling pathway (GO:0045880)3.10946249
101hydrogen peroxide biosynthetic process (GO:0050665)3.10384887
102fibroblast migration (GO:0010761)3.09011020
103adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06641605
104neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.06176968
105mucosal immune response (GO:0002385)3.06018424
106potassium ion homeostasis (GO:0055075)3.04756756
107regulation of microtubule depolymerization (GO:0031114)3.04478137
108potassium ion export (GO:0071435)3.04447063
109retinol metabolic process (GO:0042572)3.01959863
110regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00791243
111regulation of sodium ion transport (GO:0002028)3.00411455
112* sensory perception of smell (GO:0007608)22.5623362
113response to glucagon (GO:0033762)2.99054882
114positive regulation of cellular response to insulin stimulus (GO:1900078)2.97760206
115glutamate secretion (GO:0014047)2.97750280
116determination of left/right symmetry (GO:0007368)2.97170383
117calcium-mediated signaling using intracellular calcium source (GO:0035584)2.95811474
118regulation of neurotransmitter uptake (GO:0051580)2.93391801
119striatum development (GO:0021756)2.90793229
120positive regulation of neurotransmitter transport (GO:0051590)2.90541793
121apical protein localization (GO:0045176)2.89130599
122axonal fasciculation (GO:0007413)2.88895526
123organ or tissue specific immune response (GO:0002251)2.87718518
124cardiac conduction (GO:0061337)2.87038792
125cellular copper ion homeostasis (GO:0006878)2.86260989
126determination of bilateral symmetry (GO:0009855)2.86114398
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85490174
128microtubule bundle formation (GO:0001578)2.85069027
129microtubule-based process (GO:0007017)2.84661213
130specification of symmetry (GO:0009799)2.80085132
131* cellular potassium ion transport (GO:0071804)2.78916599
132* potassium ion transmembrane transport (GO:0071805)2.78916599
133aldehyde catabolic process (GO:0046185)2.77922553
134nucleoside diphosphate phosphorylation (GO:0006165)2.77782795
135carnitine metabolic process (GO:0009437)2.76383371
136reactive oxygen species biosynthetic process (GO:1903409)2.75542515
137behavioral response to ethanol (GO:0048149)2.74959058
138olfactory bulb development (GO:0021772)2.74654163
139neuroblast proliferation (GO:0007405)2.73199807
140membrane repolarization during action potential (GO:0086011)2.71768205
141epithelial cilium movement (GO:0003351)2.71514497
142phosphatidylcholine biosynthetic process (GO:0006656)2.70872998
143negative regulation of circadian rhythm (GO:0042754)2.69970929
144mating behavior (GO:0007617)2.68112230
145adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.66978360
146connective tissue development (GO:0061448)2.63271173
147negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.61848137
148organelle assembly (GO:0070925)2.61497451
149smoothened signaling pathway (GO:0007224)2.61406327
150diol metabolic process (GO:0034311)2.60993973
151multicellular organismal water homeostasis (GO:0050891)2.60593529
152negative regulation of microtubule polymerization (GO:0031115)2.60315427
153lateral sprouting from an epithelium (GO:0060601)2.60249780
154chemical homeostasis within a tissue (GO:0048875)2.58980447
155excretion (GO:0007588)2.57648759
156negative regulation of astrocyte differentiation (GO:0048712)2.57076864
157regulation of RIG-I signaling pathway (GO:0039535)2.55637855
158single fertilization (GO:0007338)2.54846107
159cilium assembly (GO:0042384)2.54566594
160cellular response to leptin stimulus (GO:0044320)2.54523868
161CDP-diacylglycerol biosynthetic process (GO:0016024)2.54201707
162phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.54047092
163water transport (GO:0006833)2.53984548
164hypotonic response (GO:0006971)2.53753632
165regulation of response to osmotic stress (GO:0047484)2.53624202
166positive regulation of triglyceride metabolic process (GO:0090208)2.52157112
167regulation of autophagic vacuole assembly (GO:2000785)2.51887713
168drug catabolic process (GO:0042737)2.50350008
169negative regulation of microtubule depolymerization (GO:0007026)2.47769024
170regulation of inclusion body assembly (GO:0090083)2.45123176
171dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44984095
172calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.44586130
173progesterone metabolic process (GO:0042448)2.44423892
174hydrogen peroxide catabolic process (GO:0042744)2.40742274
175regulation of apoptotic cell clearance (GO:2000425)2.39634646
176regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.37799934
177CDP-diacylglycerol metabolic process (GO:0046341)2.37314423
178regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.37038345
179cilium or flagellum-dependent cell motility (GO:0001539)18.7361376
180motile cilium assembly (GO:0044458)15.1677054
181* sensory perception of chemical stimulus (GO:0007606)12.6976877
182protein insertion into membrane (GO:0051205)11.6647719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.62336483
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.19310522
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.83788684
4TAF15_26573619_Chip-Seq_HEK293_Human3.36028777
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.31765120
6ZNF263_19887448_ChIP-Seq_K562_Human3.23040735
7DROSHA_22980978_ChIP-Seq_HELA_Human3.04059326
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88605596
9GBX2_23144817_ChIP-Seq_PC3_Human2.88459317
10CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36624278
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34865605
12STAT1_20625510_ChIP-Seq_HELA_Human2.10905731
13BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.09705111
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.97752175
15SMC4_20622854_ChIP-Seq_HELA_Human1.97383911
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95684745
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93225686
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91772524
19RUNX1_27514584_Chip-Seq_MCF-7_Human1.90671441
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88702338
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88702338
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87264128
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82790688
24FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.81563064
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79544504
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.75031389
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.74645259
28REST_21632747_ChIP-Seq_MESCs_Mouse1.73919947
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73210911
30TP63_23658742_ChIP-Seq_EP156T_Human1.72152392
31LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70044461
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66560948
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.66321262
34AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.65084307
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.63178702
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62477586
37GATA1_19941826_ChIP-Seq_K562_Human1.62388834
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60347971
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60335430
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58881293
41KLF5_25053715_ChIP-Seq_YYC3_Human1.57901188
42TP63_22573176_ChIP-Seq_HFKS_Human1.57393388
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56141294
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.52776853
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52732158
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51979501
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51833324
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51739850
49AHR_22903824_ChIP-Seq_MCF-7_Human1.51312479
50VDR_22108803_ChIP-Seq_LS180_Human1.51155454
51RNF2_27304074_Chip-Seq_NSC_Mouse1.50662431
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.50224020
53KDM2B_26808549_Chip-Seq_K562_Human1.48781190
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.48666954
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48144882
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47032289
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46787805
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44922341
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.44810856
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43354576
61SMRT_27268052_Chip-Seq_Bcells_Human1.41664615
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40123552
63ETV1_20927104_ChIP-Seq_GIST48_Human1.39498293
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39470741
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37614113
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37134056
67FOXA1_25552417_ChIP-Seq_VCAP_Human1.36699797
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36588953
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36306446
70* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35971220
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35481984
72SMAD4_21799915_ChIP-Seq_A2780_Human1.34680614
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.34501665
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34429620
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32794333
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32794333
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.32269275
78TP53_18474530_ChIP-ChIP_U2OS_Human1.31312212
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30773590
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30068439
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28648669
82PHF8_20622853_ChIP-Seq_HELA_Human1.28596755
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28495598
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.27658247
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26153720
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.26040880
87* SMAD4_21741376_ChIP-Seq_EPCs_Human1.25539599
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.25262279
89P300_19829295_ChIP-Seq_ESCs_Human1.24446441
90GATA3_27048872_Chip-Seq_THYMUS_Human1.23496589
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.23083351
92SOX2_20726797_ChIP-Seq_SW620_Human1.22952574
93P68_20966046_ChIP-Seq_HELA_Human1.22438247
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21816521
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20906998
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20159424
97PHF8_20622854_ChIP-Seq_HELA_Human1.19551850
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18738657
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.18432701
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.18201434
101CTCF_27219007_Chip-Seq_Bcells_Human1.17200964
102RBPJ_21746931_ChIP-Seq_IB4_Human1.17152166
103AR_21572438_ChIP-Seq_LNCaP_Human1.17057873
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16604496
105* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16291126
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.15607964
107BCAT_22108803_ChIP-Seq_LS180_Human1.14351297
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.14281069
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.14233777
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12761651
111GATA4_25053715_ChIP-Seq_YYC3_Human1.12516010
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12140703
113TAF2_19829295_ChIP-Seq_ESCs_Human1.11788985
114* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11282253
115CEBPB_22108803_ChIP-Seq_LS180_Human1.09816709
116* SMAD3_21741376_ChIP-Seq_HESCs_Human1.09375019
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09247034
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08734874
119* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08536064
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08414478
121GATA2_19941826_ChIP-Seq_K562_Human1.08302091
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07336856
123CBX2_22325352_ChIP-Seq_293T-Rex_Human1.06988895
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06481069
125* CTCF_20526341_ChIP-Seq_ESCs_Human1.06258417
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05426183
127GATA6_21074721_ChIP-Seq_CACO-2_Human1.03895774
128NFYA_21822215_ChIP-Seq_K562_Human1.03712810
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03655248
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.03510427
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.03332778
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03078126
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02968561
134RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02809756
135FOXA2_19822575_ChIP-Seq_HepG2_Human1.02687472
136GATA1_26923725_Chip-Seq_HPCs_Mouse1.02542157
137P300_27268052_Chip-Seq_Bcells_Human1.01700541
138CREB1_26743006_Chip-Seq_LNCaP_Human1.01618502
139SOX2_21211035_ChIP-Seq_LN229_Human1.00835219
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00683915
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.00366860
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99985489
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.99878378
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99566969
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.99292130
146RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98975616
147GF1_26923725_Chip-Seq_HPCs_Mouse0.97008214
148RUNX2_22187159_ChIP-Seq_PCA_Human0.96476075
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.96386628
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96131975
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95898068
152E2F1_20622854_ChIP-Seq_HELA_Human0.95402021
153TCF4_22108803_ChIP-Seq_LS180_Human0.94798391
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94377197
155NFYB_21822215_ChIP-Seq_K562_Human0.94130775
156TBL1_22424771_ChIP-Seq_293T_Human0.92739636
157WDR5_24793694_ChIP-Seq_LNCAP_Human0.92634670
158GATA3_21867929_ChIP-Seq_TH1_Mouse0.91178682
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.91059114
160RACK7_27058665_Chip-Seq_MCF-7_Human0.90973746
161* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90972583
162BCOR_27268052_Chip-Seq_Bcells_Human0.90730535
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90723189
164STAT3_23295773_ChIP-Seq_U87_Human0.90585652
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89253188
166CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88753095
167TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88681600
168TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88636056
169TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88554787
170LXR_22292898_ChIP-Seq_THP-1_Human0.88548198
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88503523
172EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88419338
173IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88002359
174ER_23166858_ChIP-Seq_MCF-7_Human0.87450500
175PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86777584
176AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86140778
177MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85767286
178SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85683539
179NCOR_22424771_ChIP-Seq_293T_Human0.85543078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system6.47649138
2MP0002277_abnormal_respiratory_mucosa4.34275152
3MP0008789_abnormal_olfactory_epithelium4.07723178
4MP0005499_abnormal_olfactory_system3.95261537
5MP0005394_taste/olfaction_phenotype3.95261537
6MP0004043_abnormal_pH_regulation3.62928996
7MP0002822_catalepsy3.51896444
8MP0009780_abnormal_chondrocyte_physiolo3.48621909
9MP0003806_abnormal_nucleotide_metabolis2.83478289
10MP0002184_abnormal_innervation2.61291325
11MP0000566_synostosis2.40826542
12MP0002168_other_aberrant_phenotype2.30234586
13MP0000383_abnormal_hair_follicle2.26168249
14MP0003880_abnormal_central_pattern2.25773842
15MP0003136_yellow_coat_color2.16586590
16MP0004019_abnormal_vitamin_homeostasis2.06664850
17MP0001485_abnormal_pinna_reflex2.03368467
18* MP0001984_abnormal_olfaction15.0355990
19MP0003656_abnormal_erythrocyte_physiolo1.96534778
20MP0010678_abnormal_skin_adnexa1.90200509
21MP0002282_abnormal_trachea_morphology1.87060444
22MP0000516_abnormal_urinary_system1.84672719
23MP0005367_renal/urinary_system_phenotyp1.84672719
24MP0001765_abnormal_ion_homeostasis1.78400150
25MP0005084_abnormal_gallbladder_morpholo1.77904897
26MP0003890_abnormal_embryonic-extraembry1.65394282
27MP0005083_abnormal_biliary_tract1.60318801
28MP0002909_abnormal_adrenal_gland1.59904113
29MP0002653_abnormal_ependyma_morphology1.55675196
30MP0002734_abnormal_mechanical_nocicepti1.54954896
31MP0002928_abnormal_bile_duct1.54804782
32MP0000678_abnormal_parathyroid_gland1.53745600
33MP0005645_abnormal_hypothalamus_physiol1.46934830
34MP0005395_other_phenotype1.45697696
35MP0001188_hyperpigmentation1.42061829
36MP0005410_abnormal_fertilization1.40187611
37MP0003252_abnormal_bile_duct1.40124129
38MP0003635_abnormal_synaptic_transmissio1.39824991
39MP0005646_abnormal_pituitary_gland1.34286249
40MP0002752_abnormal_somatic_nervous1.33363916
41MP0001486_abnormal_startle_reflex1.31000256
42MP0002272_abnormal_nervous_system1.29858327
43MP0004859_abnormal_synaptic_plasticity1.26613890
44MP0002557_abnormal_social/conspecific_i1.23548130
45MP0010155_abnormal_intestine_physiology1.22567252
46MP0001346_abnormal_lacrimal_gland1.15144888
47MP0001929_abnormal_gametogenesis1.14883235
48MP0005636_abnormal_mineral_homeostasis1.12558620
49MP0010234_abnormal_vibrissa_follicle1.11980627
50MP0002877_abnormal_melanocyte_morpholog1.10890079
51MP0001529_abnormal_vocalization1.10262607
52MP0008875_abnormal_xenobiotic_pharmacok1.10069131
53MP0003698_abnormal_male_reproductive1.09498221
54MP0002249_abnormal_larynx_morphology1.08846272
55MP0002160_abnormal_reproductive_system1.08091164
56MP0005365_abnormal_bile_salt1.06947989
57MP0002233_abnormal_nose_morphology1.04932751
58MP0002882_abnormal_neuron_morphology1.04122534
59MP0002063_abnormal_learning/memory/cond1.03930420
60MP0004270_analgesia1.03017641
61MP0005248_abnormal_Harderian_gland1.00796105
62MP0000465_gastrointestinal_hemorrhage1.00445055
63MP0003303_peritoneal_inflammation0.99436082
64MP0000778_abnormal_nervous_system0.98983185
65MP0003045_fibrosis0.98757885
66MP0005409_darkened_coat_color0.97497986
67MP0001542_abnormal_bone_strength0.93421283
68MP0004811_abnormal_neuron_physiology0.92094739
69MP0008004_abnormal_stomach_pH0.88686223
70MP0005058_abnormal_lysosome_morphology0.85628789
71MP0004145_abnormal_muscle_electrophysio0.85289526
72MP0003942_abnormal_urinary_system0.85101137
73MP0001970_abnormal_pain_threshold0.84996740
74MP0005085_abnormal_gallbladder_physiolo0.84120121
75MP0000681_abnormal_thyroid_gland0.83669387
76MP0002572_abnormal_emotion/affect_behav0.82072539
77MP0004264_abnormal_extraembryonic_tissu0.81095422
78MP0002152_abnormal_brain_morphology0.80074916
79MP0010030_abnormal_orbit_morphology0.77924997
80MP0004133_heterotaxia0.76711496
81MP0002064_seizures0.76148350
82MP0002136_abnormal_kidney_physiology0.76133626
83MP0009643_abnormal_urine_homeostasis0.75627125
84MP0003879_abnormal_hair_cell0.75236124
85MP0003453_abnormal_keratinocyte_physiol0.74598004
86MP0001849_ear_inflammation0.74076690
87MP0005623_abnormal_meninges_morphology0.73700041
88MP0009053_abnormal_anal_canal0.71778282
89MP0003075_altered_response_to0.71720795
90MP0006276_abnormal_autonomic_nervous0.71245681
91MP0005387_immune_system_phenotype0.70710567
92MP0001790_abnormal_immune_system0.70710567
93MP0005164_abnormal_response_to0.69782175
94MP0002405_respiratory_system_inflammati0.68307544
95MP0008874_decreased_physiological_sensi0.67893389
96MP0003634_abnormal_glial_cell0.67890328
97MP0005220_abnormal_exocrine_pancreas0.67679548
98MP0004883_abnormal_blood_vessel0.67284097
99MP0009745_abnormal_behavioral_response0.66634285
100MP0005408_hypopigmentation0.63529094
101MP0005165_increased_susceptibility_to0.63020896
102MP0000631_abnormal_neuroendocrine_gland0.62809031
103MP0005551_abnormal_eye_electrophysiolog0.61957497
104MP0009763_increased_sensitivity_to0.61132465
105MP0000538_abnormal_urinary_bladder0.60508078
106MP0000049_abnormal_middle_ear0.60379924
107MP0003878_abnormal_ear_physiology0.60174376
108MP0005377_hearing/vestibular/ear_phenot0.60174376
109MP0005423_abnormal_somatic_nervous0.59889920
110MP0000372_irregular_coat_pigmentation0.59776547
111MP0009379_abnormal_foot_pigmentation0.59505930
112MP0005584_abnormal_enzyme/coenzyme_acti0.59254887
113MP0001324_abnormal_eye_pigmentation0.58951017
114MP0002139_abnormal_hepatobiliary_system0.58400376
115MP0002161_abnormal_fertility/fecundity0.58309298
116MP0002067_abnormal_sensory_capabilities0.58058192
117MP0005310_abnormal_salivary_gland0.56726232
118MP0002638_abnormal_pupillary_reflex0.55282448
119MP0004510_myositis0.55154963
120MP0000534_abnormal_ureter_morphology0.54663514
121MP0005171_absent_coat_pigmentation0.52931943
122MP0002229_neurodegeneration0.51505876
123MP0009046_muscle_twitch0.51362271
124MP0003633_abnormal_nervous_system0.51225133
125MP0002084_abnormal_developmental_patter0.50895283
126MP0009703_decreased_birth_body0.50859063
127MP0005389_reproductive_system_phenotype0.50739394
128MP0000026_abnormal_inner_ear0.48348282
129MP0002098_abnormal_vibrissa_morphology0.48195478
130MP0006036_abnormal_mitochondrial_physio0.47953258
131MP0001664_abnormal_digestion0.47681154
132MP0009333_abnormal_splenocyte_physiolog0.47110704
133MP0003866_abnormal_defecation0.46613134
134MP0008873_increased_physiological_sensi0.46549728
135MP0001905_abnormal_dopamine_level0.45647843
136MP0009765_abnormal_xenobiotic_induced0.45197684
137MP0002735_abnormal_chemical_nociception0.45120244
138MP0004782_abnormal_surfactant_physiolog0.45119270
139MP0004381_abnormal_hair_follicle0.44935157
140MP0006035_abnormal_mitochondrial_morpho0.44473964
141MP0003329_amyloid_beta_deposits0.44330815
142MP0005195_abnormal_posterior_eye0.44216464
143MP0006082_CNS_inflammation0.43544272
144MP0001293_anophthalmia0.43540545
145MP0000858_altered_metastatic_potential0.43309502
146MP0002116_abnormal_craniofacial_bone0.43173878
147MP0002876_abnormal_thyroid_physiology0.41766778
148MP0001270_distended_abdomen0.41114768
149MP0002295_abnormal_pulmonary_circulatio0.41033991
150MP0002332_abnormal_exercise_endurance0.40882318
151MP0002837_dystrophic_cardiac_calcinosis0.40202645
152MP0005386_behavior/neurological_phenoty0.40139451
153MP0004924_abnormal_behavior0.40139451
154MP0004742_abnormal_vestibular_system0.40102123
155MP0003861_abnormal_nervous_system0.40044352
156MP0002733_abnormal_thermal_nociception0.39486304
157MP0005388_respiratory_system_phenotype0.39376998
158MP0002133_abnormal_respiratory_system0.39376998
159MP0004130_abnormal_muscle_cell0.39157138
160MP0001145_abnormal_male_reproductive0.38677953
161MP0003693_abnormal_embryo_hatching0.38382175
162MP0002066_abnormal_motor_capabilities/c0.37334218
163MP0009764_decreased_sensitivity_to0.35338746
164MP0002082_postnatal_lethality0.35299961
165MP0010770_preweaning_lethality0.35299961

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.60364023
2Retinal dysplasia (HP:0007973)8.77446435
3Abnormal respiratory motile cilium physiology (HP:0012261)7.10647220
4Bifid tongue (HP:0010297)7.00439105
5Limb dystonia (HP:0002451)6.33812437
6Rhinitis (HP:0012384)6.09862363
7Molar tooth sign on MRI (HP:0002419)6.07023292
8Abnormality of midbrain morphology (HP:0002418)6.07023292
9Abnormality of the nasal mucosa (HP:0000433)5.77140421
10Chronic bronchitis (HP:0004469)5.76836393
11Abnormality of macular pigmentation (HP:0008002)5.29591316
12Palpitations (HP:0001962)5.05529340
13Abnormal ciliary motility (HP:0012262)5.04696285
14Abolished electroretinogram (ERG) (HP:0000550)4.94850972
15Recurrent sinusitis (HP:0011108)4.61835557
16Dysphonia (HP:0001618)4.44391061
17Infertility (HP:0000789)4.28733455
18Abnormal respiratory motile cilium morphology (HP:0005938)4.17548327
19Abnormal respiratory epithelium morphology (HP:0012253)4.17548327
20Chronic sinusitis (HP:0011109)4.17329833
21Torticollis (HP:0000473)4.16458691
22Male infertility (HP:0003251)3.94457615
23Hyperglycinemia (HP:0002154)3.88542882
24Bony spicule pigmentary retinopathy (HP:0007737)3.81042621
25Craniofacial dystonia (HP:0012179)3.65885852
26Atonic seizures (HP:0010819)3.51167768
27Bronchiectasis (HP:0002110)3.45054844
28Focal dystonia (HP:0004373)3.37141002
29Gait imbalance (HP:0002141)3.33814616
30Congenital primary aphakia (HP:0007707)3.24121171
31Postaxial hand polydactyly (HP:0001162)3.23506674
32Occipital encephalocele (HP:0002085)3.18487026
33Chronic otitis media (HP:0000389)3.14433607
34Medial flaring of the eyebrow (HP:0010747)3.11196445
35Syncope (HP:0001279)3.09768040
36Myokymia (HP:0002411)3.08559890
37Pancreatic fibrosis (HP:0100732)3.05686560
38True hermaphroditism (HP:0010459)3.01697922
39Nephrogenic diabetes insipidus (HP:0009806)3.00207813
40Atelectasis (HP:0100750)2.99460015
41Renal hypoplasia (HP:0000089)2.96635019
42Short nail (HP:0001799)2.92354299
43Poikilocytosis (HP:0004447)2.88876504
44Hyperactive renin-angiotensin system (HP:0000841)2.86345152
45Oculomotor apraxia (HP:0000657)2.78980368
46Hypothermia (HP:0002045)2.76697730
47Cystic liver disease (HP:0006706)2.69967687
48Abnormality of dentin (HP:0010299)2.69567802
49Prolonged QT interval (HP:0001657)2.64951250
50Abnormality of sodium homeostasis (HP:0010931)2.64709742
51Chronic hepatic failure (HP:0100626)2.63742073
52Febrile seizures (HP:0002373)2.63265567
53Pancreatic cysts (HP:0001737)2.59482503
54Neuroendocrine neoplasm (HP:0100634)2.52283776
55Vacuolated lymphocytes (HP:0001922)2.49909132
56Vaginal atresia (HP:0000148)2.46027151
57Poor coordination (HP:0002370)2.44762649
58Abnormal biliary tract physiology (HP:0012439)2.42386832
59Bile duct proliferation (HP:0001408)2.42386832
60Postaxial foot polydactyly (HP:0001830)2.39215429
61Hyperglycinuria (HP:0003108)2.34130974
62Genital tract atresia (HP:0001827)2.30530685
63Constricted visual fields (HP:0001133)2.26961057
64Supernumerary spleens (HP:0009799)2.26935838
65Anosmia (HP:0000458)2.25295853
66Recurrent otitis media (HP:0000403)2.21529265
67Nephronophthisis (HP:0000090)2.21329597
68Restlessness (HP:0000711)2.18468115
69Absence seizures (HP:0002121)2.14254843
70Bronchitis (HP:0012387)2.05930132
71Sensory axonal neuropathy (HP:0003390)2.05923832
72Recurrent bronchitis (HP:0002837)2.02420356
73Narrow forehead (HP:0000341)2.00681879
74Anencephaly (HP:0002323)1.99070302
75Abnormality of serine family amino acid metabolism (HP:0010894)1.97819913
76Abnormality of glycine metabolism (HP:0010895)1.97819913
77Bell-shaped thorax (HP:0001591)1.96666612
78Congenital hepatic fibrosis (HP:0002612)1.95551502
79Furrowed tongue (HP:0000221)1.91650195
80Tubulointerstitial nephritis (HP:0001970)1.90585627
81Aplasia/Hypoplasia of the lens (HP:0008063)1.90542648
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89557536
83Complete atrioventricular canal defect (HP:0001674)1.87975397
84Severe visual impairment (HP:0001141)1.87751742
85Absent/shortened dynein arms (HP:0200106)1.87193719
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.87193719
87Absent frontal sinuses (HP:0002688)1.84093795
88Male pseudohermaphroditism (HP:0000037)1.83635707
89Agitation (HP:0000713)1.82952115
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.82241033
91Retinitis pigmentosa (HP:0000510)1.81336687
92Abnormality of the dental root (HP:0006486)1.80713777
93Taurodontia (HP:0000679)1.80713777
94Abnormality of permanent molar morphology (HP:0011071)1.80713777
95Primary atrial arrhythmia (HP:0001692)1.80134793
96Focal seizures (HP:0007359)1.77294535
97Aganglionic megacolon (HP:0002251)1.76869927
98Decreased circulating renin level (HP:0003351)1.74258198
99Supraventricular tachycardia (HP:0004755)1.73582439
100Abnormality of the phalanges of the hallux (HP:0010057)1.73367735
101Nasal polyposis (HP:0100582)1.73079298
102Abnormality of alanine metabolism (HP:0010916)1.72958472
103Hyperalaninemia (HP:0003348)1.72958472
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72958472
105Asplenia (HP:0001746)1.71948189
106Abnormality of molar morphology (HP:0011070)1.71361866
107Abnormality of molar (HP:0011077)1.71361866
108Renal salt wasting (HP:0000127)1.71145571
109Hydroureter (HP:0000072)1.70376687
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.69056895
111Abnormality of the renal medulla (HP:0100957)1.67997485
112Supraventricular arrhythmia (HP:0005115)1.67105188
113Acute encephalopathy (HP:0006846)1.66386950
114Hyperventilation (HP:0002883)1.66106378
115Abnormal rod and cone electroretinograms (HP:0008323)1.64701064
116Atrial fibrillation (HP:0005110)1.64297794
117Tubular atrophy (HP:0000092)1.64098013
118Abnormality of the vocal cords (HP:0008777)1.63834223
119Sudden death (HP:0001699)1.63729748
120Nephropathy (HP:0000112)1.63334976
121Hyperkalemia (HP:0002153)1.61438482
122Sclerocornea (HP:0000647)1.58829514
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.44514926
124Hyperaldosteronism (HP:0000859)1.44058957
125Hand muscle atrophy (HP:0009130)1.38732824
126Abnormality of renin-angiotensin system (HP:0000847)1.28265095
127Tubulointerstitial abnormality (HP:0001969)1.27708471
128Glucose intolerance (HP:0000833)1.27608314
129Abnormality of chloride homeostasis (HP:0011422)1.27256893
130Preaxial hand polydactyly (HP:0001177)1.26997358
131Stage 5 chronic kidney disease (HP:0003774)1.22609806
132Median cleft lip (HP:0000161)1.21025298
133Short thorax (HP:0010306)1.20950409
134Abnormality of monocarboxylic acid metabolism (HP:0010996)1.20147516
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.16918938
136Hypokalemic alkalosis (HP:0001949)1.16342964
137Abnormality of the distal phalanges of the toes (HP:0010182)1.15581666
138Abnormality of the frontal sinuses (HP:0002687)1.14526806
139Bifid scrotum (HP:0000048)1.13877415
140Abnormality of the dental pulp (HP:0006479)1.12011619
141Cone-rod dystrophy (HP:0000548)1.11673815
142Hyponatremia (HP:0002902)1.10965786
143Muscle fiber splitting (HP:0003555)1.05118259
144Decreased central vision (HP:0007663)1.04727559
145Fetal akinesia sequence (HP:0001989)1.03785705
146Obstructive sleep apnea (HP:0002870)1.02895566
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.00862014
148Polydipsia (HP:0001959)1.00467101
149Abnormal drinking behavior (HP:0030082)1.00467101
150Upper limb amyotrophy (HP:0009129)0.99888880
151Distal upper limb amyotrophy (HP:0007149)0.99888880
152Aplasia of the musculature (HP:0100854)0.94558489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.79462781
2EPHA24.92529901
3PHKG24.56278725
4PHKG14.56278725
5TRIB34.34338481
6CAMK2B3.18773127
7CAMK2D3.05048452
8DAPK22.87292946
9ARAF2.78907847
10CAMK2G2.71673069
11MAP3K22.59971087
12LATS12.58845637
13ERBB32.52780892
14CAMKK22.49765660
15ICK2.45910141
16CAMK1D2.43951571
17CAMK1G2.39432953
18ILK2.38109950
19PAK32.37754703
20NME12.28379246
21MAPK152.24448683
22SMG12.17804513
23CSNK1A1L1.95241900
24STK241.91366800
25NUAK11.81936933
26STK38L1.76561374
27CSNK1G31.70141772
28CSNK1G21.61923119
29RIPK41.55090607
30MAP2K71.49303057
31MAP3K31.48791079
32CSK1.45557896
33MAP3K71.43163910
34STK101.36951190
35PRKCG1.36624019
36CSNK1G11.32499258
37DYRK1B1.32238541
38CAMKK11.25879397
39BCR1.24538060
40NEK61.20451890
41EPHB11.20265896
42LATS21.19923938
43EEF2K1.19675575
44IRAK11.17026850
45IRAK21.16238894
46LRRK21.12731403
47MST1R1.12404242
48CAMK2A1.11610991
49STK381.09919807
50DAPK11.03685512
51RPS6KA21.01232889
52GRK61.01069445
53MAPKAPK30.98956388
54PNCK0.98637592
55MAP3K40.97691659
56PIM20.92653139
57NLK0.90019953
58PRKCI0.86818695
59TBK10.82287012
60TESK10.82083680
61MARK20.81877684
62FRK0.80418262
63CAMK10.79187536
64PRKD20.73567286
65BMPR20.72471696
66CAMK40.72350450
67PRKG20.71482058
68BRAF0.71340520
69GRK50.69890307
70EPHA30.69817668
71TLK10.69462161
72TTK0.69461628
73MAPK70.68876192
74PLK20.67992864
75MAP3K120.67905409
76RPS6KA40.66595839
77MUSK0.64040954
78RIPK10.63484812
79ACVR1B0.63167000
80TXK0.60403303
81MINK10.59062123
82HIPK20.58594418
83NEK90.56236718
84CDK50.56184886
85PKN10.55919922
86DAPK30.54881776
87SIK20.54695918
88PRKAA20.53903965
89STK390.51736308
90MARK10.51357854
91CDK30.50628742
92STK110.49554618
93MELK0.49506537
94CDK190.48840434
95ERBB20.46810081
96AURKA0.46292348
97CASK0.45891751
98TNIK0.44520607
99MAP2K40.43804683
100MAP2K20.43159829
101MAP3K60.42054334
102PRKCQ0.41903070
103PRKD30.41880664
104BRSK20.41180821
105ROCK20.41057389
106FER0.40197157
107PRKCD0.38520915
108CCNB10.36967531
109SGK10.36318670
110DYRK30.35469974
111MAPK110.33772658
112TAOK10.33290845
113PTK2B0.33288549
114DYRK1A0.33005656
115AKT30.32739835
116KSR20.32317654
117NTRK20.31184259
118AKT20.31017286
119PRKACA0.30695650
120PRKD10.30613346
121RET0.30113867
122ADRBK10.29789477
123PAK40.29595504
124STK160.29306368
125TRPM70.28706764
126SGK2230.27916500
127SGK4940.27916500
128OXSR10.27419335
129PAK60.27395980
130CDC42BPA0.27381989
131PRKAA10.27291709
132MET0.27128850
133FYN0.26690989
134PRKACG0.26560235
135PRKCZ0.26162387
136PDPK10.26111857
137PLK10.25862700
138EPHA40.25329025
139LMTK20.23827109
140ABL10.23376374
141CSNK1E0.23371729
142PRKCA0.23302044
143PDK10.22684152
144BMPR1B0.22627656
145ERBB40.22295273
146TYK20.21122792
147MAP2K10.20947129
148MOS0.20431166
149MAPK100.20214353
150PAK10.18921070
151STK30.18707154
152ZAP700.14226235
153PTK60.13643501
154RPS6KB20.13409649
155CHEK20.13385198
156FGFR30.12645728
157ROCK10.12260257
158PASK0.12223396
159SRC0.11583104
160MAP3K80.10968035
161CDK60.10127890
162MAPKAPK50.09163214

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.58896412
2Phenylalanine metabolism_Homo sapiens_hsa003605.40434938
3Chemical carcinogenesis_Homo sapiens_hsa052044.45330551
4Tyrosine metabolism_Homo sapiens_hsa003503.96519670
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.84906083
6Glutathione metabolism_Homo sapiens_hsa004802.67376003
7Fatty acid biosynthesis_Homo sapiens_hsa000612.17451537
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16221284
9Caffeine metabolism_Homo sapiens_hsa002322.12850362
10Retinol metabolism_Homo sapiens_hsa008302.07577401
11* Olfactory transduction_Homo sapiens_hsa0474011.3915645
12Phototransduction_Homo sapiens_hsa047441.96319319
13Morphine addiction_Homo sapiens_hsa050321.87542140
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83848714
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77168361
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72506164
17Insulin secretion_Homo sapiens_hsa049111.71227868
18Circadian entrainment_Homo sapiens_hsa047131.70614270
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66122709
20Linoleic acid metabolism_Homo sapiens_hsa005911.63877204
21Ovarian steroidogenesis_Homo sapiens_hsa049131.60331525
22Vibrio cholerae infection_Homo sapiens_hsa051101.55124911
23Gastric acid secretion_Homo sapiens_hsa049711.50742570
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50148015
25Taste transduction_Homo sapiens_hsa047421.48411715
26Bile secretion_Homo sapiens_hsa049761.48134682
27Dopaminergic synapse_Homo sapiens_hsa047281.48117220
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47627648
29Salivary secretion_Homo sapiens_hsa049701.47469460
30GABAergic synapse_Homo sapiens_hsa047271.45382868
31Glutamatergic synapse_Homo sapiens_hsa047241.45226232
32Thyroid hormone synthesis_Homo sapiens_hsa049181.40043241
33Tight junction_Homo sapiens_hsa045301.37554446
34Synaptic vesicle cycle_Homo sapiens_hsa047211.35635364
35Cholinergic synapse_Homo sapiens_hsa047251.34016690
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.29285980
37* cAMP signaling pathway_Homo sapiens_hsa040241.28665719
38Histidine metabolism_Homo sapiens_hsa003401.24528529
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23669910
40Estrogen signaling pathway_Homo sapiens_hsa049151.13716945
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05923365
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01692203
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99151803
44Gap junction_Homo sapiens_hsa045400.98161260
45GnRH signaling pathway_Homo sapiens_hsa049120.97953306
46Calcium signaling pathway_Homo sapiens_hsa040200.97715191
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96560224
48beta-Alanine metabolism_Homo sapiens_hsa004100.90947971
49Starch and sucrose metabolism_Homo sapiens_hsa005000.90879787
50Alcoholism_Homo sapiens_hsa050340.81619595
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80997480
52Parkinsons disease_Homo sapiens_hsa050120.80398442
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79388699
54Amphetamine addiction_Homo sapiens_hsa050310.78628719
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.78586382
56Adherens junction_Homo sapiens_hsa045200.76648830
57Choline metabolism in cancer_Homo sapiens_hsa052310.75328779
58Melanogenesis_Homo sapiens_hsa049160.75263488
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71667527
60Oxytocin signaling pathway_Homo sapiens_hsa049210.68810413
61Hepatitis C_Homo sapiens_hsa051600.68607076
62Notch signaling pathway_Homo sapiens_hsa043300.68416117
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66955872
64Dilated cardiomyopathy_Homo sapiens_hsa054140.66479976
65Circadian rhythm_Homo sapiens_hsa047100.66175177
66Propanoate metabolism_Homo sapiens_hsa006400.66113633
67Pancreatic secretion_Homo sapiens_hsa049720.64990224
68Nitrogen metabolism_Homo sapiens_hsa009100.64910814
69Hematopoietic cell lineage_Homo sapiens_hsa046400.64872302
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.64652022
71Renin secretion_Homo sapiens_hsa049240.63500933
72Sphingolipid metabolism_Homo sapiens_hsa006000.63366515
73Cocaine addiction_Homo sapiens_hsa050300.61439717
74Glucagon signaling pathway_Homo sapiens_hsa049220.60387654
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59972208
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58458758
77Long-term potentiation_Homo sapiens_hsa047200.58251619
78Oocyte meiosis_Homo sapiens_hsa041140.56443837
79Collecting duct acid secretion_Homo sapiens_hsa049660.55382187
80ABC transporters_Homo sapiens_hsa020100.55379087
81Fatty acid degradation_Homo sapiens_hsa000710.55087141
82Pyruvate metabolism_Homo sapiens_hsa006200.53979090
83Other glycan degradation_Homo sapiens_hsa005110.53887689
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52740341
85Purine metabolism_Homo sapiens_hsa002300.52148572
86Cardiac muscle contraction_Homo sapiens_hsa042600.50984704
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.50594760
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50019251
89Nicotine addiction_Homo sapiens_hsa050330.48621215
90Rap1 signaling pathway_Homo sapiens_hsa040150.48291654
91Complement and coagulation cascades_Homo sapiens_hsa046100.45901423
92Serotonergic synapse_Homo sapiens_hsa047260.44517806
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44028954
94Hedgehog signaling pathway_Homo sapiens_hsa043400.43726466
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.43303238
96Sulfur metabolism_Homo sapiens_hsa009200.42312999
97Alzheimers disease_Homo sapiens_hsa050100.42169405
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.41712786
99Arachidonic acid metabolism_Homo sapiens_hsa005900.39874450
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38798280
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38334725
102Oxidative phosphorylation_Homo sapiens_hsa001900.38163703
103Arginine biosynthesis_Homo sapiens_hsa002200.35641565
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34673287
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32955230
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32492939
107Lysosome_Homo sapiens_hsa041420.32014588
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31734783
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31720904
110Glycerolipid metabolism_Homo sapiens_hsa005610.30672952
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30621217
112Vitamin digestion and absorption_Homo sapiens_hsa049770.30602208
113Basal cell carcinoma_Homo sapiens_hsa052170.30385058
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30328294
115Type I diabetes mellitus_Homo sapiens_hsa049400.28884807
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.28539863
117Insulin signaling pathway_Homo sapiens_hsa049100.28309430
118N-Glycan biosynthesis_Homo sapiens_hsa005100.27635609
119Autoimmune thyroid disease_Homo sapiens_hsa053200.27385100
120PPAR signaling pathway_Homo sapiens_hsa033200.27236223
121Allograft rejection_Homo sapiens_hsa053300.26911139
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25207445
123Axon guidance_Homo sapiens_hsa043600.25116218
124Amoebiasis_Homo sapiens_hsa051460.24726548
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.24518442
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23710823
127Glioma_Homo sapiens_hsa052140.23036267
128Metabolic pathways_Homo sapiens_hsa011000.22798021
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.22769681
130Huntingtons disease_Homo sapiens_hsa050160.22312001
131Arginine and proline metabolism_Homo sapiens_hsa003300.21131130
132Graft-versus-host disease_Homo sapiens_hsa053320.20727579
133Chemokine signaling pathway_Homo sapiens_hsa040620.20494460
134Peroxisome_Homo sapiens_hsa041460.20443386
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20081872
136Phagosome_Homo sapiens_hsa041450.19030940
137Ras signaling pathway_Homo sapiens_hsa040140.18998809
138Systemic lupus erythematosus_Homo sapiens_hsa053220.18372017
139Asthma_Homo sapiens_hsa053100.18251979
140Hippo signaling pathway_Homo sapiens_hsa043900.17818639
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17115932
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.16861052
143Carbon metabolism_Homo sapiens_hsa012000.16626239
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15880807
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15472517
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.15377105
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15373683
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.15239394
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15117826
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14244814
151Endocytosis_Homo sapiens_hsa041440.13886098
152Insulin resistance_Homo sapiens_hsa049310.13044637
153Dorso-ventral axis formation_Homo sapiens_hsa043200.12802517
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11900692
155Viral myocarditis_Homo sapiens_hsa054160.11419780
156Antigen processing and presentation_Homo sapiens_hsa046120.11352765
157Staphylococcus aureus infection_Homo sapiens_hsa051500.10225841
158Prostate cancer_Homo sapiens_hsa052150.08376390
159Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07595854
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07166124
161Glycosaminoglycan degradation_Homo sapiens_hsa005310.06928825
162Pancreatic cancer_Homo sapiens_hsa052120.06429442

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