CNGB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* phototransduction (GO:0007602)9.83390821
2retinal rod cell development (GO:0046548)9.58948528
3* phototransduction, visible light (GO:0007603)9.52084314
4GMP metabolic process (GO:0046037)9.47035668
5* detection of light stimulus (GO:0009583)9.43206374
6* detection of light stimulus involved in sensory perception (GO:0050962)9.28129004
7* detection of light stimulus involved in visual perception (GO:0050908)9.28129004
8* detection of visible light (GO:0009584)9.17469832
9positive regulation of guanylate cyclase activity (GO:0031284)8.99425633
10* visual perception (GO:0007601)8.33171560
11* sensory perception of light stimulus (GO:0050953)8.23910709
12regulation of guanylate cyclase activity (GO:0031282)8.08181918
13protein-chromophore linkage (GO:0018298)7.89743511
14* sensory perception of smell (GO:0007608)7.31208719
15photoreceptor cell differentiation (GO:0046530)6.95730794
16eye photoreceptor cell differentiation (GO:0001754)6.95730794
17* detection of external stimulus (GO:0009581)6.62637666
18retina development in camera-type eye (GO:0060041)6.57626880
19* cellular response to light stimulus (GO:0071482)6.53399318
20* detection of abiotic stimulus (GO:0009582)6.50175658
21regulation of cGMP metabolic process (GO:0030823)6.08410060
22behavioral response to nicotine (GO:0035095)5.84067939
23positive regulation of cGMP biosynthetic process (GO:0030828)5.55378050
24nonmotile primary cilium assembly (GO:0035058)5.19043089
25regulation of cGMP biosynthetic process (GO:0030826)5.18731757
26cell morphogenesis involved in neuron differentiation (GO:0048667)5.02887053
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.98658142
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.87751096
29positive regulation of cGMP metabolic process (GO:0030825)4.86679847
30* sensory perception of chemical stimulus (GO:0007606)4.84869204
31pyrimidine nucleobase catabolic process (GO:0006208)4.76449600
32protein localization to cilium (GO:0061512)4.60836327
33detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.56071061
34receptor guanylyl cyclase signaling pathway (GO:0007168)4.43761868
35regulation of voltage-gated calcium channel activity (GO:1901385)4.38525292
36* sensory perception (GO:0007600)4.37678571
37transmission of nerve impulse (GO:0019226)4.27776805
38* cellular response to radiation (GO:0071478)4.17569665
39* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.06644134
40nucleobase catabolic process (GO:0046113)3.94939137
41regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.88716114
42regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.88716114
43axoneme assembly (GO:0035082)3.86905349
44behavioral response to ethanol (GO:0048149)3.74979215
45postsynaptic membrane organization (GO:0001941)3.69026018
46* response to light stimulus (GO:0009416)3.61518871
47neuron development (GO:0048666)3.61355987
48presynaptic membrane organization (GO:0097090)3.56182605
49chemosensory behavior (GO:0007635)3.51904757
50adaptation of signaling pathway (GO:0023058)3.50630273
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50544443
52behavioral response to cocaine (GO:0048148)3.45878201
53regulation of clathrin-mediated endocytosis (GO:2000369)3.45470294
54tachykinin receptor signaling pathway (GO:0007217)3.45465699
55cell proliferation in forebrain (GO:0021846)3.44903949
56presynaptic membrane assembly (GO:0097105)3.44396491
57dopamine receptor signaling pathway (GO:0007212)3.43882095
58positive regulation of neurotransmitter transport (GO:0051590)3.43774917
59regulation of penile erection (GO:0060405)3.43644120
60response to histamine (GO:0034776)3.41955839
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38391142
62prenylation (GO:0097354)3.36244939
63protein prenylation (GO:0018342)3.36244939
64dendritic spine morphogenesis (GO:0060997)3.30615511
65auditory behavior (GO:0031223)3.29488823
66positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.28350396
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26699439
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26193020
69estrogen biosynthetic process (GO:0006703)3.25766625
70indolalkylamine metabolic process (GO:0006586)3.25146871
71retina layer formation (GO:0010842)3.24169611
72neurofilament cytoskeleton organization (GO:0060052)3.23772421
73epithelial cilium movement (GO:0003351)3.23466155
74short-term memory (GO:0007614)3.22233642
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20589934
76neuron cell-cell adhesion (GO:0007158)3.17524954
77response to pheromone (GO:0019236)3.16514724
78gamma-aminobutyric acid transport (GO:0015812)3.15803560
79retinal ganglion cell axon guidance (GO:0031290)3.13942366
80regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10359894
81membrane hyperpolarization (GO:0060081)3.09108642
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04179477
83protein localization to synapse (GO:0035418)3.02565672
84synaptic transmission, glutamatergic (GO:0035249)3.00896311
85synaptic transmission, cholinergic (GO:0007271)2.99981433
86negative regulation of transcription regulatory region DNA binding (GO:2000678)2.99111482
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.98681207
88protein polyglutamylation (GO:0018095)2.97603952
89negative regulation of axon guidance (GO:1902668)2.97041821
90positive regulation of sodium ion transmembrane transport (GO:1902307)2.95981606
91adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.94669595
92regulation of collateral sprouting (GO:0048670)2.94610758
93negative regulation of cation channel activity (GO:2001258)2.94563277
94regulation of cilium movement (GO:0003352)2.93806282
95neurotransmitter-gated ion channel clustering (GO:0072578)2.90832349
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89828342
97neuronal action potential (GO:0019228)2.89630482
98neuron recognition (GO:0008038)2.88671994
99positive regulation of gastrulation (GO:2000543)2.88336352
100establishment of mitochondrion localization (GO:0051654)2.86682520
101synaptic transmission, dopaminergic (GO:0001963)2.84980998
102serotonin metabolic process (GO:0042428)2.84975923
103regulation of neurotransmitter uptake (GO:0051580)2.84558056
104membrane depolarization during action potential (GO:0086010)2.83605664
105mechanosensory behavior (GO:0007638)2.82637715
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82376182
107neuronal ion channel clustering (GO:0045161)2.81758928
108vocalization behavior (GO:0071625)2.79935272
109axonal fasciculation (GO:0007413)2.78711338
110fucose catabolic process (GO:0019317)2.78549389
111L-fucose metabolic process (GO:0042354)2.78549389
112L-fucose catabolic process (GO:0042355)2.78549389
113synapse assembly (GO:0007416)2.77444035
114cellular potassium ion homeostasis (GO:0030007)2.77174212
115primary amino compound metabolic process (GO:1901160)2.76402899
116negative regulation of calcium ion transmembrane transport (GO:1903170)2.75965248
117negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.75965248
118cilium movement (GO:0003341)2.75117077
119glutamate receptor signaling pathway (GO:0007215)2.74180922
120adult walking behavior (GO:0007628)2.74122543
121potassium ion homeostasis (GO:0055075)2.74069926
122neuronal action potential propagation (GO:0019227)2.73900867
123regulation of action potential (GO:0098900)2.72318178
124neuron-neuron synaptic transmission (GO:0007270)2.71898305
125striatum development (GO:0021756)2.71521273
126cornea development in camera-type eye (GO:0061303)2.71218228
127negative regulation of mast cell activation (GO:0033004)2.70604152
128cerebellar Purkinje cell differentiation (GO:0021702)2.70430072
129regulation of microtubule-based movement (GO:0060632)2.67588707
130substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.66730164
131substrate-independent telencephalic tangential migration (GO:0021826)2.66730164
132cellular response to electrical stimulus (GO:0071257)2.66118589
133positive regulation of cyclase activity (GO:0031281)2.65986417
134piRNA metabolic process (GO:0034587)2.65162083
135CDP-diacylglycerol biosynthetic process (GO:0016024)2.64742135
136negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63078857
137negative regulation of axon extension involved in axon guidance (GO:0048843)2.57567364
138detection of chemical stimulus involved in sensory perception (GO:0050907)2.54922340
139icosanoid secretion (GO:0032309)2.54823141
140arachidonic acid secretion (GO:0050482)2.54823141
141central nervous system projection neuron axonogenesis (GO:0021952)2.54812444
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.54553869
143glycosphingolipid biosynthetic process (GO:0006688)2.54410143
144multicellular organismal signaling (GO:0035637)2.53922271
145regulation of synapse structural plasticity (GO:0051823)2.53360162
146neuromuscular synaptic transmission (GO:0007274)2.52354700
147ionotropic glutamate receptor signaling pathway (GO:0035235)2.52278193
148cilium organization (GO:0044782)2.52214705
149sodium ion export (GO:0071436)2.51733932
150detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.51535245
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51500855
152intraciliary transport (GO:0042073)2.51468604
153indole-containing compound metabolic process (GO:0042430)2.51223971
154phospholipid translocation (GO:0045332)2.51119783
155lipid translocation (GO:0034204)2.51119783
156cilium assembly (GO:0042384)2.51089383
157synaptic vesicle maturation (GO:0016188)2.50681264
158negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50485632
159negative regulation of telomere maintenance (GO:0032205)2.49799640
160forebrain neuron differentiation (GO:0021879)2.49416184
161cilium morphogenesis (GO:0060271)2.48576933
162reflex (GO:0060004)2.48504057
163negative regulation of receptor-mediated endocytosis (GO:0048261)2.47905518
164* response to radiation (GO:0009314)2.47830457
165protein insertion into membrane (GO:0051205)2.47741588
166protein complex biogenesis (GO:0070271)2.45923728
167parturition (GO:0007567)2.45912276
168positive regulation of lyase activity (GO:0051349)2.44331440
169positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.42619467
170ganglion development (GO:0061548)2.42470704
171motile cilium assembly (GO:0044458)2.42317332
172central nervous system neuron axonogenesis (GO:0021955)2.41496437
173inner ear receptor stereocilium organization (GO:0060122)2.40166585
174mitochondrion transport along microtubule (GO:0047497)2.39667446
175establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.39667446
176* regulation of rhodopsin mediated signaling pathway (GO:0022400)16.1814777
177* rhodopsin mediated signaling pathway (GO:0016056)15.7865552
178retinal cone cell development (GO:0046549)14.2236817
179photoreceptor cell maintenance (GO:0045494)11.8992351
180photoreceptor cell development (GO:0042461)11.5366368
181eye photoreceptor cell development (GO:0042462)10.8751007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.83873007
2GBX2_23144817_ChIP-Seq_PC3_Human3.30005704
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.17534321
4VDR_22108803_ChIP-Seq_LS180_Human3.08992470
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02330564
6EZH2_22144423_ChIP-Seq_EOC_Human2.94535509
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.93016506
8ZNF274_21170338_ChIP-Seq_K562_Hela2.86615338
9DROSHA_22980978_ChIP-Seq_HELA_Human2.77634623
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63389283
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26025658
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24857294
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13664551
14TAF15_26573619_Chip-Seq_HEK293_Human2.11809037
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10784342
16IGF1R_20145208_ChIP-Seq_DFB_Human2.05742484
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96960473
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95617164
19REST_21632747_ChIP-Seq_MESCs_Mouse1.84060814
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83969917
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82021440
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81891708
23FUS_26573619_Chip-Seq_HEK293_Human1.78591783
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76866487
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.76520751
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72621943
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69195443
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69108029
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69108029
30EWS_26573619_Chip-Seq_HEK293_Human1.67921369
31CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66851185
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63331844
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.62693249
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60475636
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57121023
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56278723
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53559908
38P53_22127205_ChIP-Seq_FIBROBLAST_Human1.52037978
39SMAD3_21741376_ChIP-Seq_HESCs_Human1.51814873
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50433390
41LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47851510
42AR_25329375_ChIP-Seq_VCAP_Human1.46812668
43SMAD4_21799915_ChIP-Seq_A2780_Human1.46697085
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.45557767
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.45179194
46KDM2B_26808549_Chip-Seq_K562_Human1.42529658
47IRF1_19129219_ChIP-ChIP_H3396_Human1.41954631
48* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41817628
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.40743563
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40241300
51NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.39765643
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.39118644
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37691634
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.37393678
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.37191559
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.36839211
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35416178
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34745512
59CBP_20019798_ChIP-Seq_JUKART_Human1.34720071
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34720071
61AR_19668381_ChIP-Seq_PC3_Human1.33463620
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32537160
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32115611
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.31957073
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31869121
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.30681834
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29590850
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25962268
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25855741
70TP53_22573176_ChIP-Seq_HFKS_Human1.25315073
71P300_19829295_ChIP-Seq_ESCs_Human1.24816631
72RNF2_27304074_Chip-Seq_NSC_Mouse1.23823773
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23399513
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23361231
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23361231
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21740764
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21009784
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19583610
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19494390
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19044100
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18243335
82RUNX2_22187159_ChIP-Seq_PCA_Human1.17326789
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16332804
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15901311
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15430306
86TCF4_22108803_ChIP-Seq_LS180_Human1.15307920
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15279940
88STAT3_23295773_ChIP-Seq_U87_Human1.14989780
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.14621799
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.13298192
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12221264
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11891287
93TAF2_19829295_ChIP-Seq_ESCs_Human1.11445873
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11172158
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.10763973
96SMAD4_21741376_ChIP-Seq_HESCs_Human1.10333484
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09892919
98NANOG_19829295_ChIP-Seq_ESCs_Human1.09581601
99SOX2_19829295_ChIP-Seq_ESCs_Human1.09581601
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09304207
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08758458
102WDR5_24793694_ChIP-Seq_LNCAP_Human1.08675194
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.07373947
104ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06310060
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.06142236
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05572323
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05012292
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04961318
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.03651912
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.02889092
111AR_21572438_ChIP-Seq_LNCaP_Human1.02787949
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02785587
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02567906
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.02056831
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02015723
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.01791520
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01421739
118NCOR_22424771_ChIP-Seq_293T_Human1.01191095
119GF1_26923725_Chip-Seq_HPCs_Mouse1.01153601
120SMC4_20622854_ChIP-Seq_HELA_Human0.99979023
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99670624
122TBL1_22424771_ChIP-Seq_293T_Human0.99456329
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98553281
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98480337
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97958216
126CTCF_20526341_ChIP-Seq_ESCs_Human0.97540880
127* CTCF_27219007_Chip-Seq_Bcells_Human0.95723952
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.95640689
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95120649
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95011876
131AHR_22903824_ChIP-Seq_MCF-7_Human0.93144900
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92751301
133ER_23166858_ChIP-Seq_MCF-7_Human0.92364204
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91957333
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.91411519
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.90496866
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89898310
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89230375
139ERG_20517297_ChIP-Seq_VCAP_Human0.88682833
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87904629
141BCAT_22108803_ChIP-Seq_LS180_Human0.87791114
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87710179
143CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87436456
144* TCF4_23295773_ChIP-Seq_U87_Human0.85985085
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85298232
146NANOG_20526341_ChIP-Seq_ESCs_Human0.84343414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.87096982
2* MP0005551_abnormal_eye_electrophysiolog9.22150589
3MP0005253_abnormal_eye_physiology6.49059340
4MP0006072_abnormal_retinal_apoptosis6.03387111
5MP0001984_abnormal_olfaction5.05295618
6* MP0005195_abnormal_posterior_eye3.73154653
7MP0001324_abnormal_eye_pigmentation3.26721463
8MP0005391_vision/eye_phenotype3.21656655
9MP0003950_abnormal_plasma_membrane3.17668267
10MP0005423_abnormal_somatic_nervous3.06169686
11MP0003787_abnormal_imprinting3.06064618
12MP0002638_abnormal_pupillary_reflex3.03065571
13MP0002090_abnormal_vision2.76428185
14MP0001986_abnormal_taste_sensitivity2.60013760
15MP0008877_abnormal_DNA_methylation2.60012553
16* MP0002229_neurodegeneration2.40985416
17* MP0002752_abnormal_somatic_nervous2.14279516
18MP0002822_catalepsy1.97834867
19MP0002736_abnormal_nociception_after1.82956482
20MP0002735_abnormal_chemical_nociception1.73836631
21MP0005394_taste/olfaction_phenotype1.72558768
22MP0005499_abnormal_olfactory_system1.72558768
23MP0001529_abnormal_vocalization1.72445637
24MP0003121_genomic_imprinting1.72430707
25MP0002160_abnormal_reproductive_system1.71131067
26MP0001764_abnormal_homeostasis1.69820936
27MP0002733_abnormal_thermal_nociception1.66123769
28MP0008789_abnormal_olfactory_epithelium1.65162839
29MP0000569_abnormal_digit_pigmentation1.56111043
30MP0002653_abnormal_ependyma_morphology1.56051431
31* MP0002882_abnormal_neuron_morphology1.49930247
32MP0003122_maternal_imprinting1.45041352
33MP0001485_abnormal_pinna_reflex1.44643707
34MP0008872_abnormal_physiological_respon1.41829464
35MP0001502_abnormal_circadian_rhythm1.41029459
36MP0002163_abnormal_gland_morphology1.40178254
37MP0002876_abnormal_thyroid_physiology1.37418532
38MP0003195_calcinosis1.33549415
39MP0006292_abnormal_olfactory_placode1.33481018
40MP0003890_abnormal_embryonic-extraembry1.27388276
41MP0005389_reproductive_system_phenotype1.22595884
42MP0001440_abnormal_grooming_behavior1.20183968
43MP0004133_heterotaxia1.18665177
44MP0000372_irregular_coat_pigmentation1.13420408
45MP0000427_abnormal_hair_cycle1.11235304
46MP0001486_abnormal_startle_reflex1.09277656
47MP0005379_endocrine/exocrine_gland_phen1.07949720
48MP0008875_abnormal_xenobiotic_pharmacok1.07469519
49MP0002837_dystrophic_cardiac_calcinosis1.05291620
50MP0003123_paternal_imprinting1.04022455
51MP0004019_abnormal_vitamin_homeostasis1.03741910
52MP0005410_abnormal_fertilization1.03720068
53MP0002332_abnormal_exercise_endurance1.02409589
54MP0005197_abnormal_uvea_morphology1.01561014
55MP0003880_abnormal_central_pattern1.01416268
56MP0002127_abnormal_cardiovascular_syste1.01400417
57MP0004233_abnormal_muscle_weight1.01062763
58MP0002751_abnormal_autonomic_nervous0.93128297
59MP0005083_abnormal_biliary_tract0.88344103
60MP0003136_yellow_coat_color0.86104895
61MP0003698_abnormal_male_reproductive0.85447049
62MP0002184_abnormal_innervation0.84857153
63* MP0002272_abnormal_nervous_system0.84681921
64MP0001919_abnormal_reproductive_system0.81198979
65MP0008995_early_reproductive_senescence0.80489347
66MP0004043_abnormal_pH_regulation0.79749892
67MP0002210_abnormal_sex_determination0.79415129
68MP0003634_abnormal_glial_cell0.79102138
69MP0000538_abnormal_urinary_bladder0.78976170
70MP0002734_abnormal_mechanical_nocicepti0.78892923
71MP0004885_abnormal_endolymph0.76697048
72MP0004782_abnormal_surfactant_physiolog0.74790062
73MP0004270_analgesia0.74412872
74MP0005646_abnormal_pituitary_gland0.71797571
75MP0003635_abnormal_synaptic_transmissio0.67551251
76MP0005187_abnormal_penis_morphology0.62734584
77MP0005645_abnormal_hypothalamus_physiol0.61979467
78MP0001286_abnormal_eye_development0.60878429
79MP0001963_abnormal_hearing_physiology0.60634026
80MP0009046_muscle_twitch0.59257134
81MP0002067_abnormal_sensory_capabilities0.59096698
82MP0002102_abnormal_ear_morphology0.58207683
83MP0002064_seizures0.57804787
84MP0000631_abnormal_neuroendocrine_gland0.57454517
85MP0004145_abnormal_muscle_electrophysio0.55755212
86MP0002063_abnormal_learning/memory/cond0.55293142
87MP0002572_abnormal_emotion/affect_behav0.52411253
88MP0001188_hyperpigmentation0.50658342
89MP0010386_abnormal_urinary_bladder0.50140728
90MP0005084_abnormal_gallbladder_morpholo0.48961195
91MP0000465_gastrointestinal_hemorrhage0.48780465
92MP0002928_abnormal_bile_duct0.48131974
93MP0009745_abnormal_behavioral_response0.47891747
94MP0004859_abnormal_synaptic_plasticity0.47290612
95MP0004215_abnormal_myocardial_fiber0.46007514
96MP0001968_abnormal_touch/_nociception0.45628155
97MP0005595_abnormal_vascular_smooth0.45625832
98MP0002557_abnormal_social/conspecific_i0.44881260
99MP0004742_abnormal_vestibular_system0.44750898
100MP0000026_abnormal_inner_ear0.44701480
101MP0004142_abnormal_muscle_tone0.39203770
102MP0002152_abnormal_brain_morphology0.37980268
103MP0004085_abnormal_heartbeat0.35906480
104MP0005376_homeostasis/metabolism_phenot0.34963110
105MP0008058_abnormal_DNA_repair0.34651720
106MP0005620_abnormal_muscle_contractility0.33851181
107MP0005248_abnormal_Harderian_gland0.33004692
108MP0000778_abnormal_nervous_system0.31509541
109MP0001293_anophthalmia0.31505691
110MP0004924_abnormal_behavior0.29352014
111MP0005386_behavior/neurological_phenoty0.29352014
112MP0003045_fibrosis0.29082733
113MP0001661_extended_life_span0.28936193
114MP0001905_abnormal_dopamine_level0.26712421
115MP0005193_abnormal_anterior_eye0.23663250
116MP0002066_abnormal_motor_capabilities/c0.23342514
117MP0002909_abnormal_adrenal_gland0.22748952
118MP0008569_lethality_at_weaning0.22478050
119MP0003646_muscle_fatigue0.21921778
120MP0001501_abnormal_sleep_pattern0.21887125
121* MP0004811_abnormal_neuron_physiology0.20402507
122MP0008004_abnormal_stomach_pH0.20113080
123MP0004147_increased_porphyrin_level0.19726105
124MP0003252_abnormal_bile_duct0.19250494
125MP0002697_abnormal_eye_size0.18877149
126MP0006276_abnormal_autonomic_nervous0.18372754
127MP0001177_atelectasis0.18012471
128MP0003943_abnormal_hepatobiliary_system0.17792099
129MP0005310_abnormal_salivary_gland0.17643850
130MP0003633_abnormal_nervous_system0.16341743
131MP0003861_abnormal_nervous_system0.15991522
132MP0001970_abnormal_pain_threshold0.15397575
133MP0000955_abnormal_spinal_cord0.15089179
134MP0008775_abnormal_heart_ventricle0.14796791
135MP0004036_abnormal_muscle_relaxation0.13844967
136MP0002108_abnormal_muscle_morphology0.12954639

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)8.85267734
2Central scotoma (HP:0000603)8.40470240
3Chorioretinal atrophy (HP:0000533)7.87982895
4Abnormality of macular pigmentation (HP:0008002)7.78806572
5Attenuation of retinal blood vessels (HP:0007843)7.23997192
6Scotoma (HP:0000575)7.18629132
7Pendular nystagmus (HP:0012043)7.11029191
8Dyschromatopsia (HP:0007641)7.05779724
9Abolished electroretinogram (ERG) (HP:0000550)6.68244390
10Decreased central vision (HP:0007663)6.29399237
11* Type II diabetes mellitus (HP:0005978)5.37670744
12* Photophobia (HP:0000613)5.31947872
13Severe visual impairment (HP:0001141)5.13576809
14Increased corneal curvature (HP:0100692)4.81849833
15Keratoconus (HP:0000563)4.81849833
16Macular degeneration (HP:0000608)4.78898405
17Posterior subcapsular cataract (HP:0007787)4.57585054
18Vitreoretinal degeneration (HP:0000655)4.52692612
19Cone-rod dystrophy (HP:0000548)4.37023490
20Constricted visual fields (HP:0001133)4.32875721
21Choroideremia (HP:0001139)4.31878612
22* Retinitis pigmentosa (HP:0000510)4.20492226
23Type II lissencephaly (HP:0007260)3.73980188
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.57273749
25Hyperventilation (HP:0002883)3.32486418
26Myokymia (HP:0002411)3.25197541
27Limb dystonia (HP:0002451)3.02357642
28Progressive visual loss (HP:0000529)2.93250219
29Lissencephaly (HP:0001339)2.92732660
30Polyphagia (HP:0002591)2.89410116
31Gait imbalance (HP:0002141)2.87304547
32Congenital primary aphakia (HP:0007707)2.85324826
33Focal seizures (HP:0007359)2.82165590
34Focal motor seizures (HP:0011153)2.80484091
35Subcapsular cataract (HP:0000523)2.77147559
36Hypothermia (HP:0002045)2.62580824
37Broad-based gait (HP:0002136)2.59380771
38Nephrogenic diabetes insipidus (HP:0009806)2.58809222
39Tubular atrophy (HP:0000092)2.57542046
40Medial flaring of the eyebrow (HP:0010747)2.54397490
41Abnormality of the renal cortex (HP:0011035)2.53647961
42Gaze-evoked nystagmus (HP:0000640)2.50924150
43Optic disc pallor (HP:0000543)2.47834320
44Pachygyria (HP:0001302)2.44607835
45Retinal atrophy (HP:0001105)2.38229284
46Congenital sensorineural hearing impairment (HP:0008527)2.36783617
47* Wide nasal bridge (HP:0000431)2.34195925
48Agitation (HP:0000713)2.32678712
49True hermaphroditism (HP:0010459)2.22129135
50Hypoplasia of the brainstem (HP:0002365)2.19264268
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.19264268
52Intestinal atresia (HP:0011100)2.19155349
53Abnormal drinking behavior (HP:0030082)2.18964493
54Polydipsia (HP:0001959)2.18964493
55Poor coordination (HP:0002370)2.18767706
56Drooling (HP:0002307)2.17995119
57Inability to walk (HP:0002540)2.16772041
58Male pseudohermaphroditism (HP:0000037)2.15473422
59Abnormal pancreas size (HP:0012094)2.11171033
60Absent speech (HP:0001344)2.07820851
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.05619189
62Amblyopia (HP:0000646)2.03971699
63Dialeptic seizures (HP:0011146)2.03045845
64Abnormality of the labia minora (HP:0012880)2.02037973
65Congenital stationary night blindness (HP:0007642)15.7735404
66Absent rod-and cone-mediated responses on ERG (HP:0007688)10.7109236
67* Bony spicule pigmentary retinopathy (HP:0007737)10.3400110
68Abnormal rod and cone electroretinograms (HP:0008323)10.3117995
69Occipital encephalocele (HP:0002085)1.98485709
70Vaginal atresia (HP:0000148)1.96858547
71Genetic anticipation (HP:0003743)1.95617167
72Narrow forehead (HP:0000341)1.95128073
73Excessive salivation (HP:0003781)1.94396579
74Progressive inability to walk (HP:0002505)1.93051582
75Methylmalonic acidemia (HP:0002912)1.88015617
76Genital tract atresia (HP:0001827)1.87903717
77Rib fusion (HP:0000902)1.86978446
78Protruding tongue (HP:0010808)1.85015589
79Polyuria (HP:0000103)1.84545268
80Optic nerve hypoplasia (HP:0000609)1.83201618
81Lipid accumulation in hepatocytes (HP:0006561)1.83174114
82Atonic seizures (HP:0010819)1.82945961
83Increased hepatocellular lipid droplets (HP:0006565)1.82464187
84Thyroid-stimulating hormone excess (HP:0002925)1.81305797
85Febrile seizures (HP:0002373)1.80132235
86Aplasia/Hypoplasia of the lens (HP:0008063)1.79830638
87Impaired vibration sensation in the lower limbs (HP:0002166)1.79024214
88Acute necrotizing encephalopathy (HP:0006965)1.78598252
89Mitochondrial inheritance (HP:0001427)1.78379554
90Hypoplasia of the uterus (HP:0000013)1.77227782
91Dyskinesia (HP:0100660)1.75222182
92Dandy-Walker malformation (HP:0001305)1.74548251
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74525885
94Decreased circulating renin level (HP:0003351)1.73963118
95Increased CSF lactate (HP:0002490)1.73038807
96Pancreatic fibrosis (HP:0100732)1.72294656
97* Optic atrophy (HP:0000648)1.62062660
98Recurrent sinusitis (HP:0011108)1.54755833
99Aplasia/Hypoplasia of the fovea (HP:0008060)1.49825406
100Hypoplasia of the fovea (HP:0007750)1.49825406
101Abnormality of midbrain morphology (HP:0002418)1.49423329
102Molar tooth sign on MRI (HP:0002419)1.49423329
103Polar cataract (HP:0010696)1.47070117
104Pancreatic cysts (HP:0001737)1.46550928
105Abnormality of the fovea (HP:0000493)1.46493244
106Interstitial pulmonary disease (HP:0006530)1.41606203
107Cystic liver disease (HP:0006706)1.39568631
108Retinal dysplasia (HP:0007973)1.37874533
109Abnormal respiratory motile cilium physiology (HP:0012261)1.34672332
110Epileptic encephalopathy (HP:0200134)1.31675778
111Horizontal nystagmus (HP:0000666)1.29813477
112Astigmatism (HP:0000483)1.28762334
113Sclerocornea (HP:0000647)1.27351526
114Specific learning disability (HP:0001328)1.25587079
115Abnormal respiratory motile cilium morphology (HP:0005938)1.20561358
116Abnormal respiratory epithelium morphology (HP:0012253)1.20561358
117Severe Myopia (HP:0011003)1.20349948
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.17502603
119Left ventricular hypertrophy (HP:0001712)1.17193615
120Decreased testicular size (HP:0008734)1.14422060
121Chronic hepatic failure (HP:0100626)1.14243951
122Abnormal ciliary motility (HP:0012262)1.14196472
123Prolonged QT interval (HP:0001657)1.14171056
124Broad foot (HP:0001769)1.13625233
125Aplasia/Hypoplasia of the macula (HP:0008059)1.13597804
126Aplasia/Hypoplasia affecting the retina (HP:0008061)1.11746436
127Postaxial hand polydactyly (HP:0001162)1.11105886
128Chorioretinal coloboma (HP:0000567)1.11000533
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.09840042
130Absent/shortened dynein arms (HP:0200106)1.09840042
131Retinal detachment (HP:0000541)1.09454639
132Nephronophthisis (HP:0000090)1.08998137
133Cerebellar dysplasia (HP:0007033)1.03362707
134Asthma (HP:0002099)1.00439703
135Rhinitis (HP:0012384)1.00138941
136Furrowed tongue (HP:0000221)0.98991157
137Visual hallucinations (HP:0002367)0.98197359
138Syncope (HP:0001279)0.96605562
139Congenital hepatic fibrosis (HP:0002612)0.95248571
140Dysdiadochokinesis (HP:0002075)0.94916299
141Recurrent otitis media (HP:0000403)0.91208252
142Anencephaly (HP:0002323)0.89916561
143Truncal ataxia (HP:0002078)0.87877350
144Abnormal EKG (HP:0003115)0.87402856
145Abnormality of the renal medulla (HP:0100957)0.84888125
146Septo-optic dysplasia (HP:0100842)0.84266187
147Postaxial foot polydactyly (HP:0001830)0.80603688
148Hypermetropia (HP:0000540)0.80017653
149Hypodontia (HP:0000668)0.79218827
150Short foot (HP:0001773)0.79021182
151Progressive cerebellar ataxia (HP:0002073)0.77128809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.41939615
2PBK5.60883857
3WNK32.70878978
4PINK12.62195940
5ADRBK22.56369409
6IRAK22.51950702
7PHKG12.28971856
8PHKG22.28971856
9CCNB12.16115258
10ICK2.13558539
11TRIM282.13304783
12BMPR1B2.02596312
13INSRR2.00729650
14DYRK21.85883833
15NTRK31.81834103
16WNK41.80258800
17SIK21.79578586
18CAMK1G1.74015657
19CAMK1D1.73732156
20MAP4K21.54274785
21CDK31.51978114
22NTRK21.50277497
23MAPK71.49802455
24STK381.48609533
25ERBB31.47996193
26MAPK151.43513018
27CAMKK21.41649567
28CDK121.39332556
29ZAK1.34565076
30CAMK2D1.33991706
31MAP3K101.33012985
32HIPK21.32118098
33STK391.31643187
34ADRBK11.25592560
35DAPK21.25000717
36RPS6KA41.23504838
37BCR1.21158809
38SGK4941.20853636
39SGK2231.20853636
40EPHA41.19059208
41OXSR11.17666157
42DYRK31.15476287
43BRD41.14945945
44ACVR1B1.11030954
45TAOK31.09401693
46TNK21.03430214
47PRKCZ1.01268877
48AKT31.00893885
49MARK10.99224563
50PRKCE0.98592738
51CSNK1G30.97784822
52ERBB20.97371751
53PRKD30.97125222
54NEK20.96957693
55MAPK120.93634216
56PAK60.92581585
57DYRK1A0.90170911
58SRPK10.89797259
59NUAK10.89707159
60CSNK1D0.83719959
61CSNK1G10.82867647
62STK38L0.82569304
63SGK20.82288819
64TLK10.82016052
65NEK10.80041280
66PAK30.79203047
67CAMK10.78353157
68VRK10.78130368
69EPHA30.77165393
70PRKAA10.77145901
71PRKAA20.74474728
72CDK90.73888058
73MAP3K40.73633376
74PKN10.71887536
75PRPF4B0.70387638
76CAMK2A0.67036503
77TTK0.64779455
78PRKD20.64403095
79STK160.63861772
80PRKCI0.63763612
81GRK70.63724327
82SGK30.63215952
83PRKCG0.62874808
84NEK60.62113597
85CAMKK10.60694019
86PRKACG0.59148334
87MARK30.58932742
88PRKCH0.57925086
89MAP2K40.56904665
90PRKCB0.56818580
91FGFR20.56528252
92CAMK2B0.56422353
93AKT20.56297022
94GRK50.55455112
95MAP2K70.53567194
96DYRK1B0.53038394
97FRK0.52991730
98RPS6KB20.52717374
99CAMK2G0.52141406
100MKNK20.51118832
101MUSK0.50859872
102TNIK0.50809280
103MAPK130.50361058
104CAMK40.49533220
105CSNK1A10.49260673
106PRKG10.49157634
107PTK2B0.49072303
108CASK0.48422254
109WNK10.48144367
110RPS6KA30.45820955
111WEE10.45355276
112PNCK0.44828591
113BCKDK0.43994440
114RPS6KA50.43882573
115CSNK1G20.43837332
116MAPKAPK50.43029947
117CSNK1E0.42430556
118CSNK1A1L0.42115843
119CDK70.41539006
120STK110.41121187
121CHEK20.40639536
122FES0.40515536
123EPHB20.40297831
124PRKACA0.40124453
125MAP3K70.39768878
126MAP2K60.39360774
127SGK10.39306731
128MAPK90.37767884
129GSK3B0.36470546
130NME10.36317090
131IRAK10.36156464
132PLK20.35934624
133MYLK0.35890802
134RPS6KB10.35708900
135BRSK20.35037984
136UHMK10.34063802
137MARK20.33952361
138PRKCQ0.33820598
139MAPK140.33646686
140PLK30.33317979
141FER0.32237314
142TAF10.32191863
143RPS6KA20.31793292
144MINK10.31557899
145PRKCA0.31137149
146CDK50.30375152

Predicted pathways (KEGG)

RankGene SetZ-score
1* Olfactory transduction_Homo sapiens_hsa047403.07962967
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24213278
3Oxidative phosphorylation_Homo sapiens_hsa001902.20524118
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04027080
5Linoleic acid metabolism_Homo sapiens_hsa005912.02429615
6* Phototransduction_Homo sapiens_hsa0474415.1791479
7Butanoate metabolism_Homo sapiens_hsa006501.96314710
8Synaptic vesicle cycle_Homo sapiens_hsa047211.82082922
9Parkinsons disease_Homo sapiens_hsa050121.81018055
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80180610
11Ether lipid metabolism_Homo sapiens_hsa005651.62828132
12GABAergic synapse_Homo sapiens_hsa047271.49929058
13Tryptophan metabolism_Homo sapiens_hsa003801.49922716
14Protein export_Homo sapiens_hsa030601.40604409
15Morphine addiction_Homo sapiens_hsa050321.31325693
16Axon guidance_Homo sapiens_hsa043601.29601354
17Long-term depression_Homo sapiens_hsa047301.21713399
18Huntingtons disease_Homo sapiens_hsa050161.19427196
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.17634739
20Alzheimers disease_Homo sapiens_hsa050101.17505104
21Circadian entrainment_Homo sapiens_hsa047131.17365790
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17287854
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.09288835
24Cholinergic synapse_Homo sapiens_hsa047251.07970755
25Basal transcription factors_Homo sapiens_hsa030221.03209876
26Glutamatergic synapse_Homo sapiens_hsa047241.01420561
27Circadian rhythm_Homo sapiens_hsa047100.97755448
28Fanconi anemia pathway_Homo sapiens_hsa034600.96415528
29Dopaminergic synapse_Homo sapiens_hsa047280.95157688
30Selenocompound metabolism_Homo sapiens_hsa004500.93625508
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92569946
32Regulation of autophagy_Homo sapiens_hsa041400.91510722
33Propanoate metabolism_Homo sapiens_hsa006400.90895487
34Insulin secretion_Homo sapiens_hsa049110.90639264
35Histidine metabolism_Homo sapiens_hsa003400.89894394
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89098636
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88521937
38Hedgehog signaling pathway_Homo sapiens_hsa043400.87758059
39Primary bile acid biosynthesis_Homo sapiens_hsa001200.86738611
40Nicotine addiction_Homo sapiens_hsa050330.86597834
41Retinol metabolism_Homo sapiens_hsa008300.86565326
42Chemical carcinogenesis_Homo sapiens_hsa052040.84938535
43Homologous recombination_Homo sapiens_hsa034400.84082203
44Peroxisome_Homo sapiens_hsa041460.78880576
45Arachidonic acid metabolism_Homo sapiens_hsa005900.76149683
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75870666
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75728932
48Fat digestion and absorption_Homo sapiens_hsa049750.75663099
49ABC transporters_Homo sapiens_hsa020100.71980330
50Serotonergic synapse_Homo sapiens_hsa047260.70899846
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70711216
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70552180
53Steroid biosynthesis_Homo sapiens_hsa001000.68777340
54Salivary secretion_Homo sapiens_hsa049700.67694627
55Purine metabolism_Homo sapiens_hsa002300.67353927
56Dorso-ventral axis formation_Homo sapiens_hsa043200.65677885
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62872844
58* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62829612
59beta-Alanine metabolism_Homo sapiens_hsa004100.61565567
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61337180
61Oxytocin signaling pathway_Homo sapiens_hsa049210.57978954
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56644117
63* cAMP signaling pathway_Homo sapiens_hsa040240.55762370
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55445527
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54805461
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54577545
67RNA degradation_Homo sapiens_hsa030180.54070680
68Renin secretion_Homo sapiens_hsa049240.53130114
69Taste transduction_Homo sapiens_hsa047420.53106855
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50213073
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48232146
72Dilated cardiomyopathy_Homo sapiens_hsa054140.46506124
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45131737
74Fatty acid metabolism_Homo sapiens_hsa012120.44631716
75Inositol phosphate metabolism_Homo sapiens_hsa005620.43892854
76Metabolic pathways_Homo sapiens_hsa011000.43789168
77Gastric acid secretion_Homo sapiens_hsa049710.43395693
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42860052
79Fatty acid degradation_Homo sapiens_hsa000710.42716692
80Calcium signaling pathway_Homo sapiens_hsa040200.42389118
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41543666
82Alcoholism_Homo sapiens_hsa050340.40796174
83Cardiac muscle contraction_Homo sapiens_hsa042600.39962636
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39778836
85Sulfur relay system_Homo sapiens_hsa041220.37982833
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37717966
87Ovarian steroidogenesis_Homo sapiens_hsa049130.35444738
88Cocaine addiction_Homo sapiens_hsa050300.34124561
89RNA polymerase_Homo sapiens_hsa030200.33809891
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31576314
91Nitrogen metabolism_Homo sapiens_hsa009100.30852574
92mTOR signaling pathway_Homo sapiens_hsa041500.30514201
93Fructose and mannose metabolism_Homo sapiens_hsa000510.30495980
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29642169
95Thyroid hormone synthesis_Homo sapiens_hsa049180.28889794
96Glucagon signaling pathway_Homo sapiens_hsa049220.28680694
97Amphetamine addiction_Homo sapiens_hsa050310.28102194
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27990983
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27391792
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.26466379
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26211978
102Bile secretion_Homo sapiens_hsa049760.25907404
103Caffeine metabolism_Homo sapiens_hsa002320.25431817
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.23955765
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23760346
106Pancreatic secretion_Homo sapiens_hsa049720.22691486
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22294398
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21220302
109Chemokine signaling pathway_Homo sapiens_hsa040620.21151873
110GnRH signaling pathway_Homo sapiens_hsa049120.21126625
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20846861
112Type II diabetes mellitus_Homo sapiens_hsa049300.19935636
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.19805597
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19143998
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18961062
116Ras signaling pathway_Homo sapiens_hsa040140.18881763
117Long-term potentiation_Homo sapiens_hsa047200.17333387
118Arginine biosynthesis_Homo sapiens_hsa002200.17017893
119Galactose metabolism_Homo sapiens_hsa000520.16227234
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15974378
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.15628910
122Collecting duct acid secretion_Homo sapiens_hsa049660.15560155
123AMPK signaling pathway_Homo sapiens_hsa041520.15473275
124Vibrio cholerae infection_Homo sapiens_hsa051100.15006622
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14650924
126Gap junction_Homo sapiens_hsa045400.14339240
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14244043
128Melanogenesis_Homo sapiens_hsa049160.13726057
129Mineral absorption_Homo sapiens_hsa049780.13644496
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.11492147
131mRNA surveillance pathway_Homo sapiens_hsa030150.10879826
132Glycerolipid metabolism_Homo sapiens_hsa005610.10416232
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09778941
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09644097
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09526348
136Notch signaling pathway_Homo sapiens_hsa043300.09268396
137N-Glycan biosynthesis_Homo sapiens_hsa005100.08963458
138Sphingolipid metabolism_Homo sapiens_hsa006000.08685060
139Estrogen signaling pathway_Homo sapiens_hsa049150.08182186
140HIF-1 signaling pathway_Homo sapiens_hsa040660.07871510
141Biosynthesis of amino acids_Homo sapiens_hsa012300.06867722
142MAPK signaling pathway_Homo sapiens_hsa040100.04998085
143Insulin signaling pathway_Homo sapiens_hsa049100.04500184
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.03851939
145Fatty acid biosynthesis_Homo sapiens_hsa000610.03240174
146Vitamin digestion and absorption_Homo sapiens_hsa049770.02937861

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