CNIH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.30181620
2ATP synthesis coupled proton transport (GO:0015986)5.93345939
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.93345939
4chaperone-mediated protein transport (GO:0072321)5.80099332
5protein neddylation (GO:0045116)5.69601261
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.31755757
7cullin deneddylation (GO:0010388)5.18839317
8protein deneddylation (GO:0000338)5.17642570
9proteasome assembly (GO:0043248)5.03425596
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.88638486
11fatty acid elongation (GO:0030497)4.74232998
12respiratory electron transport chain (GO:0022904)4.72757464
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61645285
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.61645285
15NADH dehydrogenase complex assembly (GO:0010257)4.61645285
16electron transport chain (GO:0022900)4.58738094
17protein complex biogenesis (GO:0070271)4.45943005
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.22668347
19regulation of cellular amino acid metabolic process (GO:0006521)4.12842038
20signal peptide processing (GO:0006465)4.01418511
21mitochondrial respiratory chain complex assembly (GO:0033108)3.98988822
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93786491
23negative regulation of ligase activity (GO:0051352)3.92297749
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.92297749
25ribosome assembly (GO:0042255)3.89378002
26cholesterol biosynthetic process (GO:0006695)3.82078401
27amino acid salvage (GO:0043102)3.76673693
28L-methionine salvage (GO:0071267)3.76673693
29L-methionine biosynthetic process (GO:0071265)3.76673693
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75008255
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71289615
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.68302679
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65218112
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65218112
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59187221
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57605745
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57605745
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57605745
39axon ensheathment in central nervous system (GO:0032291)3.47166873
40central nervous system myelination (GO:0022010)3.47166873
41mitotic metaphase plate congression (GO:0007080)3.45417225
42peptidyl-histidine modification (GO:0018202)3.45085901
43sterol biosynthetic process (GO:0016126)3.41006469
447-methylguanosine mRNA capping (GO:0006370)3.39961957
45CENP-A containing nucleosome assembly (GO:0034080)3.39921765
46antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.39701027
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39356559
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.39356559
497-methylguanosine RNA capping (GO:0009452)3.37357880
50RNA capping (GO:0036260)3.37357880
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.36934622
52termination of RNA polymerase III transcription (GO:0006386)3.36934622
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36776149
54protein targeting to mitochondrion (GO:0006626)3.36712930
55formation of translation preinitiation complex (GO:0001731)3.36279430
56nucleotide transmembrane transport (GO:1901679)3.35983055
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.34290329
58ribosomal large subunit biogenesis (GO:0042273)3.32516835
59positive regulation of ligase activity (GO:0051351)3.32204983
60cotranslational protein targeting to membrane (GO:0006613)3.30048607
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.29455484
62positive regulation of mitochondrial fission (GO:0090141)3.29270946
632-deoxyribonucleotide biosynthetic process (GO:0009265)3.29257544
64deoxyribose phosphate biosynthetic process (GO:0046385)3.29257544
65aldehyde catabolic process (GO:0046185)3.26969370
66substantia nigra development (GO:0021762)3.26843555
67chromatin remodeling at centromere (GO:0031055)3.26256058
68respiratory chain complex IV assembly (GO:0008535)3.26190935
69establishment of protein localization to mitochondrion (GO:0072655)3.25543534
70DNA double-strand break processing (GO:0000729)3.24350571
71regulation of cellular amine metabolic process (GO:0033238)3.22910923
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20748502
73L-serine metabolic process (GO:0006563)3.19654545
74protein targeting to ER (GO:0045047)3.19380055
75protein localization to endoplasmic reticulum (GO:0070972)3.16355543
76water-soluble vitamin biosynthetic process (GO:0042364)3.13534585
77oxidative phosphorylation (GO:0006119)3.10368371
78metaphase plate congression (GO:0051310)3.10044745
79negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.08879269
80protein localization to mitochondrion (GO:0070585)3.08738878
81long-chain fatty acid biosynthetic process (GO:0042759)3.05302903
82de novo posttranslational protein folding (GO:0051084)3.04161217
83de novo protein folding (GO:0006458)3.03899847
84translation (GO:0006412)3.03120984
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.02378261
86deoxyribonucleotide biosynthetic process (GO:0009263)3.01783418
87establishment of integrated proviral latency (GO:0075713)3.01766568
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01232774
89GTP biosynthetic process (GO:0006183)3.00881111
90nucleobase-containing small molecule interconversion (GO:0015949)2.96960022
91regulation of metalloenzyme activity (GO:0048552)2.94733295
92guanosine-containing compound biosynthetic process (GO:1901070)2.94349473
93positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93320828
94regulation of mitochondrial translation (GO:0070129)2.92790775
95protein localization to kinetochore (GO:0034501)2.90850904
96protein-cofactor linkage (GO:0018065)2.90175656
97ribosomal small subunit biogenesis (GO:0042274)2.89480970
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89421572
99lactate metabolic process (GO:0006089)2.88791196
100hydrogen ion transmembrane transport (GO:1902600)2.88719432
101spindle checkpoint (GO:0031577)2.88229926
102isoprenoid biosynthetic process (GO:0008299)2.87956069
103histone exchange (GO:0043486)2.87896802
104regulation of ubiquitin-protein transferase activity (GO:0051438)2.86864079
105establishment of viral latency (GO:0019043)2.86665123
106positive regulation of actin filament depolymerization (GO:0030836)2.86635726
107cytochrome complex assembly (GO:0017004)2.86570280
108mitotic spindle checkpoint (GO:0071174)2.86497714
109regulation of ligase activity (GO:0051340)2.85337243
110spliceosomal snRNP assembly (GO:0000387)2.84756466
111rRNA modification (GO:0000154)2.84339076
112purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83900065
113positive regulation of cell cycle arrest (GO:0071158)2.83837404
114purine nucleobase biosynthetic process (GO:0009113)2.83199284
115translational termination (GO:0006415)2.82521966
116ribosomal small subunit assembly (GO:0000028)2.82173593
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82132435
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82132435
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79956986
120viral transcription (GO:0019083)2.79545131
121IMP biosynthetic process (GO:0006188)2.78074471
122mitotic nuclear envelope reassembly (GO:0007084)2.77616500
123nuclear envelope reassembly (GO:0031468)2.77616500
124pteridine-containing compound biosynthetic process (GO:0042559)2.68029126
125telomere maintenance via semi-conservative replication (GO:0032201)2.65256065
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.64688049
127negative regulation of sister chromatid segregation (GO:0033046)2.64688049
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64688049
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64688049
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64688049
131DNA ligation (GO:0006266)2.60754240
132mitotic spindle assembly checkpoint (GO:0007094)2.56939155
133negative regulation of chromosome segregation (GO:0051985)2.56627548
134IMP metabolic process (GO:0046040)2.56107343
135spindle assembly checkpoint (GO:0071173)2.55530891
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55431511
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55431511
138nucleobase biosynthetic process (GO:0046112)2.54819072
139rRNA methylation (GO:0031167)2.54672395
1404-hydroxyproline metabolic process (GO:0019471)2.54158468
141translational initiation (GO:0006413)2.51891865
142tRNA aminoacylation for protein translation (GO:0006418)2.51773458
143DNA damage response, detection of DNA damage (GO:0042769)2.51131139
144DNA strand elongation involved in DNA replication (GO:0006271)2.50012820
145protein localization to chromosome, centromeric region (GO:0071459)2.48472529
146amino acid activation (GO:0043038)2.48282372
147tRNA aminoacylation (GO:0043039)2.48282372
148DNA replication-independent nucleosome assembly (GO:0006336)2.47983945
149DNA replication-independent nucleosome organization (GO:0034724)2.47983945
150regulation of sister chromatid segregation (GO:0033045)2.47709187
151regulation of mitotic sister chromatid separation (GO:0010965)2.47709187
152regulation of mitotic sister chromatid segregation (GO:0033047)2.47709187
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.47361673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.37721924
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.82016950
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.76858004
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.98240555
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.96272369
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78967706
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.69903665
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.33274318
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.32577555
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.30259580
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20917469
12E2F7_22180533_ChIP-Seq_HELA_Human3.16280714
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09084246
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.04933892
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63444750
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58970216
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57588725
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.54237453
19DCP1A_22483619_ChIP-Seq_HELA_Human2.49040640
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47484153
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46576978
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45847286
23ELK1_19687146_ChIP-ChIP_HELA_Human2.45381361
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35101681
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.27482258
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15729478
27VDR_23849224_ChIP-Seq_CD4+_Human2.15640632
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11462198
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.00465794
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97865160
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93282322
32XRN2_22483619_ChIP-Seq_HELA_Human1.91694783
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.91401844
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91028677
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87408211
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.84888461
37GABP_19822575_ChIP-Seq_HepG2_Human1.78841358
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77674769
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74841860
40TTF2_22483619_ChIP-Seq_HELA_Human1.72760498
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69411524
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68926978
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68066957
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62901090
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57938379
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54887069
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52695583
48AR_21909140_ChIP-Seq_LNCAP_Human1.51953026
49SOX17_20123909_ChIP-Seq_XEN_Mouse1.50913459
50FOXP3_21729870_ChIP-Seq_TREG_Human1.50893840
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39087582
52VDR_22108803_ChIP-Seq_LS180_Human1.37650351
53TAF15_26573619_Chip-Seq_HEK293_Human1.36692346
54IGF1R_20145208_ChIP-Seq_DFB_Human1.36381585
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36120707
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35114498
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.34736585
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33862695
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32383307
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.31025584
61MYC_18940864_ChIP-ChIP_HL60_Human1.28522816
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.23497570
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.23319908
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.23174439
65EWS_26573619_Chip-Seq_HEK293_Human1.22932947
66FUS_26573619_Chip-Seq_HEK293_Human1.17715689
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13891117
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09657135
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09111812
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07182140
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07152691
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06813423
73SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06392450
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.06183353
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04728928
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04491516
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03684161
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03411201
79EOMES_21245162_ChIP-Seq_HESCs_Human1.02947838
80P300_19829295_ChIP-Seq_ESCs_Human1.02794416
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02636237
82ER_23166858_ChIP-Seq_MCF-7_Human1.02477139
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00973355
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99966985
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99813160
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99773658
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99773658
88JUN_21703547_ChIP-Seq_K562_Human0.99073428
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99007467
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98417916
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98404677
92GBX2_23144817_ChIP-Seq_PC3_Human0.97354700
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97348073
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96985803
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95086597
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94667214
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94174049
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93524732
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93076047
100NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92972153
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92904308
102ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92695504
103ZNF274_21170338_ChIP-Seq_K562_Hela0.92683964
104REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91921350
105HTT_18923047_ChIP-ChIP_STHdh_Human0.91640493
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90919675
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88103360
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87585370
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87227955
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87029588
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86518641
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.85821144
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85775934
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85480780
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85107134
116BRD4_25478319_ChIP-Seq_HGPS_Human0.84949859
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.84651261
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84478651
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84310710
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83266474
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82697571
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82313810
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82077652
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80208875
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79888688
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79545198
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78582884
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.78121380
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.78073394
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77768006
131SOX2_19829295_ChIP-Seq_ESCs_Human0.76382978
132NANOG_19829295_ChIP-Seq_ESCs_Human0.76382978
133ELF5_23300383_ChIP-Seq_T47D_Human0.76256448
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76025642
135PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.75550450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.06938379
2MP0001529_abnormal_vocalization3.64626242
3MP0008438_abnormal_cutaneous_collagen3.28720217
4MP0003941_abnormal_skin_development3.18020542
5MP0001905_abnormal_dopamine_level2.89966181
6MP0009379_abnormal_foot_pigmentation2.83539314
7MP0001542_abnormal_bone_strength2.77572844
8MP0003186_abnormal_redox_activity2.68568510
9MP0000372_irregular_coat_pigmentation2.62347489
10MP0005503_abnormal_tendon_morphology2.58031945
11MP0006054_spinal_hemorrhage2.52547970
12MP0009697_abnormal_copulation2.49924798
13MP0010234_abnormal_vibrissa_follicle2.41395255
14MP0002736_abnormal_nociception_after2.28402359
15MP0006276_abnormal_autonomic_nervous2.23214343
16MP0008058_abnormal_DNA_repair2.19141075
17MP0008007_abnormal_cellular_replicative2.12574489
18MP0010094_abnormal_chromosome_stability2.10617770
19MP0010352_gastrointestinal_tract_polyps2.10398818
20MP0005408_hypopigmentation2.10340239
21MP0003718_maternal_effect2.03038387
22MP0001984_abnormal_olfaction2.02234635
23MP0003880_abnormal_central_pattern1.97115257
24MP0000920_abnormal_myelination1.95381905
25MP0002735_abnormal_chemical_nociception1.94947487
26MP0009250_abnormal_appendicular_skeleto1.94743149
27MP0009780_abnormal_chondrocyte_physiolo1.87328686
28MP0003111_abnormal_nucleus_morphology1.86389122
29MP0005367_renal/urinary_system_phenotyp1.85087731
30MP0000516_abnormal_urinary_system1.85087731
31MP0003077_abnormal_cell_cycle1.82181596
32MP0003950_abnormal_plasma_membrane1.81614118
33MP0001968_abnormal_touch/_nociception1.81535377
34MP0003786_premature_aging1.81118739
35MP0010030_abnormal_orbit_morphology1.79400267
36MP0001986_abnormal_taste_sensitivity1.75159782
37MP0008932_abnormal_embryonic_tissue1.75133061
38MP0004134_abnormal_chest_morphology1.72719723
39MP0005171_absent_coat_pigmentation1.70525456
40MP0002837_dystrophic_cardiac_calcinosis1.67234751
41MP0009384_cardiac_valve_regurgitation1.66759680
42MP0004957_abnormal_blastocyst_morpholog1.64840871
43MP0006036_abnormal_mitochondrial_physio1.62929243
44MP0004272_abnormal_basement_membrane1.62869896
45MP0004147_increased_porphyrin_level1.60193576
46MP0005084_abnormal_gallbladder_morpholo1.59966426
47MP0010368_abnormal_lymphatic_system1.59707705
48MP0008789_abnormal_olfactory_epithelium1.57287726
49MP0003122_maternal_imprinting1.53181151
50MP0003567_abnormal_fetal_cardiomyocyte1.50688153
51MP0002234_abnormal_pharynx_morphology1.49914720
52MP0002734_abnormal_mechanical_nocicepti1.49432752
53MP0002295_abnormal_pulmonary_circulatio1.48560201
54MP0010678_abnormal_skin_adnexa1.39285538
55MP0003656_abnormal_erythrocyte_physiolo1.36785627
56MP0003123_paternal_imprinting1.34901658
57MP0008057_abnormal_DNA_replication1.34546038
58MP0003279_aneurysm1.33056101
59MP0002938_white_spotting1.31615917
60MP0000566_synostosis1.31016235
61MP0002751_abnormal_autonomic_nervous1.27570345
62MP0001730_embryonic_growth_arrest1.27517092
63MP0002282_abnormal_trachea_morphology1.26750363
64MP0004142_abnormal_muscle_tone1.25162895
65MP0001293_anophthalmia1.24149274
66MP0001970_abnormal_pain_threshold1.21077531
67MP0005451_abnormal_body_composition1.19456891
68MP0002139_abnormal_hepatobiliary_system1.19106121
69MP0003121_genomic_imprinting1.18525513
70MP0004270_analgesia1.18423804
71MP0003693_abnormal_embryo_hatching1.18309893
72MP0003890_abnormal_embryonic-extraembry1.15103137
73MP0009053_abnormal_anal_canal1.13897365
74MP0001697_abnormal_embryo_size1.13833607
75MP0002160_abnormal_reproductive_system1.13811781
76MP0003942_abnormal_urinary_system1.13425777
77MP0006035_abnormal_mitochondrial_morpho1.12855042
78MP0005275_abnormal_skin_tensile1.10960550
79MP0002102_abnormal_ear_morphology1.10010532
80MP0002084_abnormal_developmental_patter1.09769223
81MP0004215_abnormal_myocardial_fiber1.08926230
82MP0002090_abnormal_vision1.08853001
83MP0006292_abnormal_olfactory_placode1.08026870
84MP0006072_abnormal_retinal_apoptosis1.07631027
85MP0002272_abnormal_nervous_system1.05821303
86MP0000762_abnormal_tongue_morphology1.05424123
87MP0000350_abnormal_cell_proliferation1.04440438
88MP0003195_calcinosis1.03843107
89MP0008004_abnormal_stomach_pH1.03370564
90MP0001485_abnormal_pinna_reflex1.02725006
91MP0002733_abnormal_thermal_nociception1.02000412
92MP0005085_abnormal_gallbladder_physiolo1.01178654
93MP0001666_abnormal_nutrient_absorption1.01125336
94MP0001672_abnormal_embryogenesis/_devel1.00168071
95MP0005380_embryogenesis_phenotype1.00168071
96MP0002697_abnormal_eye_size0.99774133
97MP0005187_abnormal_penis_morphology0.99672514
98MP0005257_abnormal_intraocular_pressure0.99323417
99MP0003136_yellow_coat_color0.98991791
100MP0002085_abnormal_embryonic_tissue0.98568203
101MP0005508_abnormal_skeleton_morphology0.98256607
102MP0005164_abnormal_response_to0.96362873
103MP0000383_abnormal_hair_follicle0.95705847
104MP0002060_abnormal_skin_morphology0.93771429
105MP0001286_abnormal_eye_development0.92596697
106MP0000049_abnormal_middle_ear0.90635793
107MP0000358_abnormal_cell_content/0.89673349
108MP0001299_abnormal_eye_distance/0.89281084
109MP0003329_amyloid_beta_deposits0.87017655
110MP0000163_abnormal_cartilage_morphology0.86800396
111MP0008875_abnormal_xenobiotic_pharmacok0.86347914
112MP0005332_abnormal_amino_acid0.86304058
113MP0003984_embryonic_growth_retardation0.86096793
114MP0005360_urolithiasis0.85592504
115MP0008260_abnormal_autophagy0.84966654
116MP0005197_abnormal_uvea_morphology0.84425737
117MP0003283_abnormal_digestive_organ0.83940016
118MP0003119_abnormal_digestive_system0.83701541
119MP0002088_abnormal_embryonic_growth/wei0.83593543
120MP0000647_abnormal_sebaceous_gland0.83585075
121MP0001727_abnormal_embryo_implantation0.82590330
122MP0000537_abnormal_urethra_morphology0.81829406
123MP0005365_abnormal_bile_salt0.79376521
124MP0010386_abnormal_urinary_bladder0.79091985
125MP0003935_abnormal_craniofacial_develop0.78794497
126MP0003755_abnormal_palate_morphology0.78552936
127MP0002080_prenatal_lethality0.77919225
128MP0003252_abnormal_bile_duct0.77398316
129MP0000749_muscle_degeneration0.76265142
130MP0003937_abnormal_limbs/digits/tail_de0.75529062
131MP0005248_abnormal_Harderian_gland0.75454444
132MP0005395_other_phenotype0.75105043
133MP0002132_abnormal_respiratory_system0.74363234
134MP0003634_abnormal_glial_cell0.73737155
135MP0001243_abnormal_dermal_layer0.73712535
136MP0001177_atelectasis0.73405738
137MP0002177_abnormal_outer_ear0.73178263
138MP0001661_extended_life_span0.72831018
139MP0001764_abnormal_homeostasis0.72333413
140MP0003011_delayed_dark_adaptation0.70782584
141MP0003385_abnormal_body_wall0.70131746
142MP0000013_abnormal_adipose_tissue0.69858499
143MP0001963_abnormal_hearing_physiology0.69499034
144MP0005083_abnormal_biliary_tract0.69103164
145MP0005646_abnormal_pituitary_gland0.68944754
146MP0000343_altered_response_to0.68119751
147MP0002752_abnormal_somatic_nervous0.67962641
148MP0001958_emphysema0.67690423
149MP0005394_taste/olfaction_phenotype0.67244191
150MP0005499_abnormal_olfactory_system0.67244191
151MP0000026_abnormal_inner_ear0.66260784
152MP0005595_abnormal_vascular_smooth0.66238434
153MP0002163_abnormal_gland_morphology0.64985590
154MP0005376_homeostasis/metabolism_phenot0.64703559
155MP0003315_abnormal_perineum_morphology0.60461269
156MP0000534_abnormal_ureter_morphology0.60371728
157MP0002115_abnormal_skeleton_extremities0.60125851
158MP0002113_abnormal_skeleton_development0.59905064
159MP0002233_abnormal_nose_morphology0.59785167
160MP0002064_seizures0.59385863

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.85258176
2Abnormality of glycolysis (HP:0004366)5.45068237
3Increased serum pyruvate (HP:0003542)5.45068237
4Abnormal mitochondria in muscle tissue (HP:0008316)5.37189810
5Mitochondrial inheritance (HP:0001427)5.11984756
6Acute encephalopathy (HP:0006846)4.86293784
7Progressive macrocephaly (HP:0004481)4.79794110
8Hepatocellular necrosis (HP:0001404)4.67790190
9Increased CSF lactate (HP:0002490)4.41505119
10Hepatic necrosis (HP:0002605)3.91574002
11Increased hepatocellular lipid droplets (HP:0006565)3.66879170
12Irregular epiphyses (HP:0010582)3.52334609
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.45072983
14Lipid accumulation in hepatocytes (HP:0006561)3.36985037
15Renal Fanconi syndrome (HP:0001994)3.32993653
16Leukodystrophy (HP:0002415)3.30107949
17Respiratory failure (HP:0002878)3.28383265
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22312593
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22312593
203-Methylglutaconic aciduria (HP:0003535)3.20165199
21Cerebral edema (HP:0002181)3.11162850
22Increased serum lactate (HP:0002151)3.07041650
23Cerebral hypomyelination (HP:0006808)2.99430038
24Exercise intolerance (HP:0003546)2.98780015
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93510325
26Neuroendocrine neoplasm (HP:0100634)2.91710343
27Parakeratosis (HP:0001036)2.90144627
28Lactic acidosis (HP:0003128)2.89671950
29Reduced antithrombin III activity (HP:0001976)2.87974197
30Autoamputation (HP:0001218)2.84350466
31Increased intramyocellular lipid droplets (HP:0012240)2.82086375
32Abnormality of methionine metabolism (HP:0010901)2.78144324
33Adrenal hypoplasia (HP:0000835)2.73561553
34Hypoglycemic seizures (HP:0002173)2.69913716
35Pheochromocytoma (HP:0002666)2.68823312
36Hypoglycemic coma (HP:0001325)2.67740957
37Optic disc pallor (HP:0000543)2.64793911
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60959971
39Premature rupture of membranes (HP:0001788)2.57675331
40Congenital ichthyosiform erythroderma (HP:0007431)2.57433897
41Abnormality of dentin (HP:0010299)2.55469557
42Exertional dyspnea (HP:0002875)2.55129848
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54420154
44Abnormal protein N-linked glycosylation (HP:0012347)2.54420154
45Abnormal protein glycosylation (HP:0012346)2.54420154
46Abnormal glycosylation (HP:0012345)2.54420154
47Prolonged partial thromboplastin time (HP:0003645)2.52683653
48Sensory axonal neuropathy (HP:0003390)2.47319910
49CNS demyelination (HP:0007305)2.40484962
50Increased muscle lipid content (HP:0009058)2.39502779
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36245997
52Abnormality of serum amino acid levels (HP:0003112)2.34204468
53Hypoplastic pelvis (HP:0008839)2.30739967
54Microglossia (HP:0000171)2.29060923
55Postnatal microcephaly (HP:0005484)2.25858231
56Hyperinsulinemic hypoglycemia (HP:0000825)2.23392040
57Onycholysis (HP:0001806)2.23043538
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21389094
59Retinal dysplasia (HP:0007973)2.21266846
60Metaphyseal dysplasia (HP:0100255)2.19786772
61Abnormality of cells of the erythroid lineage (HP:0012130)2.18965055
62Hypobetalipoproteinemia (HP:0003563)2.18788386
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16393382
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.16393382
65Absent epiphyses (HP:0010577)2.14760804
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.14760804
67Abnormal lung lobation (HP:0002101)2.14624154
68Abnormal umbilical cord blood vessels (HP:0011403)2.13043365
69Single umbilical artery (HP:0001195)2.13043365
70Abnormality of the fetal cardiovascular system (HP:0010948)2.13043365
71Respiratory difficulties (HP:0002880)2.12268711
72Megaloblastic anemia (HP:0001889)2.12137063
73Macrocytic anemia (HP:0001972)2.10477154
74Poor head control (HP:0002421)2.09726419
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08372613
76Abnormality of alanine metabolism (HP:0010916)2.08372613
77Hyperalaninemia (HP:0003348)2.08372613
78Emotional lability (HP:0000712)2.08322196
79Symptomatic seizures (HP:0011145)2.07771620
80Epiphyseal dysplasia (HP:0002656)2.07157897
81Abnormality of the umbilical cord (HP:0010881)2.00764304
82Abnormality of placental membranes (HP:0011409)1.99801262
83Amniotic constriction ring (HP:0009775)1.99801262
84X-linked dominant inheritance (HP:0001423)1.99027105
85Congenital, generalized hypertrichosis (HP:0004540)1.98836887
86Hypothermia (HP:0002045)1.96709675
87Abnormalities of placenta or umbilical cord (HP:0001194)1.96521460
88Hyperglycinemia (HP:0002154)1.96306361
89Abnormality of the anterior horn cell (HP:0006802)1.95304497
90Degeneration of anterior horn cells (HP:0002398)1.95304497
91Abnormal number of erythroid precursors (HP:0012131)1.93976595
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92553286
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92064098
94Rhabdomyosarcoma (HP:0002859)1.91976189
95Delayed gross motor development (HP:0002194)1.91440300
96Vertebral compression fractures (HP:0002953)1.90259561
97Abnormality of renal resorption (HP:0011038)1.89813179
98Confusion (HP:0001289)1.89730135
99Type I transferrin isoform profile (HP:0003642)1.89550435
100Ankle contracture (HP:0006466)1.88123842
101Ependymoma (HP:0002888)1.87145983
102Palpitations (HP:0001962)1.86668923
103Delusions (HP:0000746)1.85455494
104Neoplasm of the peripheral nervous system (HP:0100007)1.84120483
105Hypoplastic left heart (HP:0004383)1.83735328
106Intrahepatic cholestasis (HP:0001406)1.82637512
107Delayed epiphyseal ossification (HP:0002663)1.80715175
108Abnormality of the labia minora (HP:0012880)1.78363497
109Abnormal gallbladder physiology (HP:0012438)1.77986913
110Cholecystitis (HP:0001082)1.77986913
111Glossoptosis (HP:0000162)1.77679795
112Irregular vertebral endplates (HP:0003301)1.74469387
113Thyroid carcinoma (HP:0002890)1.73760628
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73062621
115Sparse eyelashes (HP:0000653)1.72707327
116Small epiphyses (HP:0010585)1.70707637
117Poor suck (HP:0002033)1.69659640
118Aplasia/hypoplasia of the uterus (HP:0008684)1.69294964
119Generalized aminoaciduria (HP:0002909)1.69171383
120Abnormal auditory evoked potentials (HP:0006958)1.68568431
121Methylmalonic aciduria (HP:0012120)1.67399792
122Abnormal hemoglobin (HP:0011902)1.65873818
123Lethargy (HP:0001254)1.65471872
124Birth length less than 3rd percentile (HP:0003561)1.65134125
125Methylmalonic acidemia (HP:0002912)1.64823927
126Glycosuria (HP:0003076)1.64306574
127Abnormality of urine glucose concentration (HP:0011016)1.64306574
128Soft skin (HP:0000977)1.63741428
129Pterygium (HP:0001059)1.63161000
130Pancreatic islet-cell hyperplasia (HP:0004510)1.62267564
131Flat capital femoral epiphysis (HP:0003370)1.61527486
132Colon cancer (HP:0003003)1.61076754
133Abnormality of the intrinsic pathway (HP:0010989)1.60234196
134Meckel diverticulum (HP:0002245)1.59398624
135Biliary tract neoplasm (HP:0100574)1.58587169
136Hyperphosphaturia (HP:0003109)1.58032911
137Conjunctival hamartoma (HP:0100780)1.58021359
138Abnormal epiphyseal ossification (HP:0010656)1.57868540
139CNS hypomyelination (HP:0003429)1.57846508
140Blindness (HP:0000618)1.57149582
141Stridor (HP:0010307)1.57055047
142Prolonged neonatal jaundice (HP:0006579)1.56930209
143Epiphyseal stippling (HP:0010655)1.56608366
144Protrusio acetabuli (HP:0003179)1.56080288
145Fibular aplasia (HP:0002990)1.56064565
146Neoplasm of the adrenal gland (HP:0100631)1.54667005
147Abnormality of vitamin B metabolism (HP:0004340)1.54596930
148Neoplasm of the colon (HP:0100273)1.54329885
149Medulloblastoma (HP:0002885)1.53308936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK13.54650865
2PBK3.41238202
3EIF2AK13.16531539
4CASK2.91691553
5NME22.91076379
6ARAF2.90189165
7BCR2.57649058
8BUB12.54978481
9STK392.45971742
10PIM22.41119929
11MAP3K122.39882068
12TRIM282.36098852
13NME12.29448337
14EIF2AK32.22063607
15TTK2.14192993
16STK162.13448791
17CCNB12.08641486
18OXSR11.94990282
19CDK191.92821651
20MST41.87101348
21MAPKAPK51.84066724
22VRK21.83547266
23TAF11.79583334
24BRAF1.76673162
25PLK41.72737468
26TESK11.70593199
27VRK11.69791757
28TESK21.60460366
29MKNK21.48454342
30FRK1.47485838
31DYRK21.47159923
32STK31.44911867
33MKNK11.43680605
34WEE11.41656281
35CSNK1G31.41395770
36PLK21.41241779
37ERBB41.33317597
38ZAK1.30910735
39BMPR1B1.27968096
40MST1R1.27538856
41WNK31.24165116
42ABL21.17148410
43PRPF4B1.16117405
44TSSK61.15463642
45FGFR21.12749236
46STK38L1.11841263
47MYLK1.10860783
48PASK1.09791104
49ERBB31.09279912
50NUAK11.09115853
51CDK141.08581774
52ILK1.06828326
53EPHA20.99707477
54PLK30.98413683
55CDK80.96906717
56MAP4K20.96386825
57LATS20.94478555
58CSNK1A1L0.93228100
59MAP2K70.91034916
60CDK180.89865402
61SRPK10.88473630
62BCKDK0.86354706
63CSNK1G20.85570742
64ADRBK20.84518758
65SIK30.83150383
66NTRK10.82415244
67NEK10.82116026
68CAMK2B0.81517212
69PNCK0.81088067
70CSNK1G10.80665063
71CDK150.80516809
72FLT30.79879060
73MAP3K110.79821275
74ROCK20.78843205
75AURKB0.78836609
76BMPR20.78508027
77BRSK20.78221993
78NEK90.77657496
79STK240.77433399
80MAPK130.76611323
81PTK20.76567919
82WNK40.76231218
83AURKA0.75928643
84PDK20.75560054
85TRPM70.74920636
86MET0.73700403
87CDK11A0.73466395
88TGFBR10.70545004
89PAK40.70054900
90PAK10.67098306
91STK40.65913112
92CAMK2D0.65413466
93CAMK2G0.65382957
94FGFR10.64515533
95UHMK10.63179481
96ACVR1B0.62697350
97MINK10.60265795
98TNIK0.59734829
99MOS0.57947897
100GRK10.57552801
101LATS10.56811359
102LRRK20.55365661
103MUSK0.54993032
104TIE10.54155186
105NEK60.54152384
106PRKCE0.52434757
107GRK50.51226083
108STK100.50599567
109CHEK20.50393684
110YES10.50184324
111CDK30.49323749
112ADRBK10.49095162
113EPHB20.47714780
114CSNK2A10.46230009
115CAMK2A0.45447338
116PAK20.44915702
117PHKG20.44799158
118PHKG10.44799158
119CDC70.42854199
120SCYL20.41627666
121PLK10.40878654
122FER0.40303160
123CSNK1E0.39892201
124CDK60.38534110
125BRSK10.37551152
126PIK3CA0.37355717
127CDK70.36632785
128RPS6KA40.36247623
129CLK10.35637074
130MAP3K40.35514765
131KDR0.35059556
132RPS6KA50.34253164
133ATM0.34076299
134DYRK30.33463388
135CSNK2A20.33018476
136MAP2K10.32367329
137MAPKAPK30.31541845
138MAP3K30.30542889
139EIF2AK20.29217421
140PRKG20.29066603

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.75192376
2Oxidative phosphorylation_Homo sapiens_hsa001904.62565835
3Protein export_Homo sapiens_hsa030604.02613377
4Parkinsons disease_Homo sapiens_hsa050123.84214559
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.32067430
6Ribosome_Homo sapiens_hsa030103.21709525
7RNA polymerase_Homo sapiens_hsa030202.69268871
8Alzheimers disease_Homo sapiens_hsa050102.68126221
9Steroid biosynthesis_Homo sapiens_hsa001002.68115929
10Huntingtons disease_Homo sapiens_hsa050162.63384051
11Fatty acid elongation_Homo sapiens_hsa000622.42916412
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18939149
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94829942
14Vibrio cholerae infection_Homo sapiens_hsa051101.90665856
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88875610
16Collecting duct acid secretion_Homo sapiens_hsa049661.73430501
17Pyrimidine metabolism_Homo sapiens_hsa002401.61931611
18Sulfur metabolism_Homo sapiens_hsa009201.60930877
19Glutathione metabolism_Homo sapiens_hsa004801.51565420
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49796431
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42224708
22Nucleotide excision repair_Homo sapiens_hsa034201.40868481
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35091587
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34589894
25DNA replication_Homo sapiens_hsa030301.34301725
26Fanconi anemia pathway_Homo sapiens_hsa034601.34301111
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26440867
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26423865
29Basal transcription factors_Homo sapiens_hsa030221.26362258
30Pyruvate metabolism_Homo sapiens_hsa006201.18051681
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15673934
32Phagosome_Homo sapiens_hsa041451.14920149
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14831741
34Caffeine metabolism_Homo sapiens_hsa002321.13019092
35Ether lipid metabolism_Homo sapiens_hsa005651.08449453
36Spliceosome_Homo sapiens_hsa030401.07280349
37Cardiac muscle contraction_Homo sapiens_hsa042601.05362136
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00271914
39Purine metabolism_Homo sapiens_hsa002301.00146570
40Selenocompound metabolism_Homo sapiens_hsa004500.99282780
41Mismatch repair_Homo sapiens_hsa034300.99173807
42Rheumatoid arthritis_Homo sapiens_hsa053230.98355431
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91664856
44RNA transport_Homo sapiens_hsa030130.89739897
45Folate biosynthesis_Homo sapiens_hsa007900.88561386
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87519297
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.86765692
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.86333935
49Metabolic pathways_Homo sapiens_hsa011000.84284426
50Sphingolipid metabolism_Homo sapiens_hsa006000.82095053
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.81584059
52Arachidonic acid metabolism_Homo sapiens_hsa005900.80671720
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80185601
54Arginine and proline metabolism_Homo sapiens_hsa003300.78846290
55p53 signaling pathway_Homo sapiens_hsa041150.78146771
56mRNA surveillance pathway_Homo sapiens_hsa030150.75642065
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74829545
58Fatty acid degradation_Homo sapiens_hsa000710.74342695
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74070407
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73912561
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73152180
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72196594
63RNA degradation_Homo sapiens_hsa030180.71548239
64Vitamin B6 metabolism_Homo sapiens_hsa007500.70685442
65Synaptic vesicle cycle_Homo sapiens_hsa047210.70162808
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69483927
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68251275
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66982911
69Homologous recombination_Homo sapiens_hsa034400.66951330
70Carbon metabolism_Homo sapiens_hsa012000.66429207
71Chemical carcinogenesis_Homo sapiens_hsa052040.65710263
72Base excision repair_Homo sapiens_hsa034100.65610601
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65065246
74Cell cycle_Homo sapiens_hsa041100.64470366
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63795073
76Peroxisome_Homo sapiens_hsa041460.62288544
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60773331
78Propanoate metabolism_Homo sapiens_hsa006400.58919552
79TGF-beta signaling pathway_Homo sapiens_hsa043500.58517854
80Vitamin digestion and absorption_Homo sapiens_hsa049770.57639183
81Starch and sucrose metabolism_Homo sapiens_hsa005000.56787963
82N-Glycan biosynthesis_Homo sapiens_hsa005100.55211496
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53675065
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53657981
85Linoleic acid metabolism_Homo sapiens_hsa005910.53407357
86Tryptophan metabolism_Homo sapiens_hsa003800.53391936
87Complement and coagulation cascades_Homo sapiens_hsa046100.52337338
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.51813882
89Tyrosine metabolism_Homo sapiens_hsa003500.51629602
90Fat digestion and absorption_Homo sapiens_hsa049750.51079781
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.47613021
92Pentose phosphate pathway_Homo sapiens_hsa000300.47205572
93Arginine biosynthesis_Homo sapiens_hsa002200.47133804
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46788869
95Histidine metabolism_Homo sapiens_hsa003400.45710215
96Biosynthesis of amino acids_Homo sapiens_hsa012300.45708773
97Butanoate metabolism_Homo sapiens_hsa006500.45424296
98Phototransduction_Homo sapiens_hsa047440.44833909
99Hippo signaling pathway_Homo sapiens_hsa043900.44809678
100Basal cell carcinoma_Homo sapiens_hsa052170.44140309
101Serotonergic synapse_Homo sapiens_hsa047260.43531387
102Malaria_Homo sapiens_hsa051440.41409523
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40886798
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40696927
105Shigellosis_Homo sapiens_hsa051310.39039695
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35870400
107Phenylalanine metabolism_Homo sapiens_hsa003600.35034059
108Epstein-Barr virus infection_Homo sapiens_hsa051690.34010266
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32876666
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32498606
111Wnt signaling pathway_Homo sapiens_hsa043100.32434656
112Mineral absorption_Homo sapiens_hsa049780.30985539
113Hedgehog signaling pathway_Homo sapiens_hsa043400.30223024
114Sulfur relay system_Homo sapiens_hsa041220.29016934
115Regulation of autophagy_Homo sapiens_hsa041400.28991582
116Galactose metabolism_Homo sapiens_hsa000520.28308598
117ECM-receptor interaction_Homo sapiens_hsa045120.24170586
118Retinol metabolism_Homo sapiens_hsa008300.22112376
119Fatty acid metabolism_Homo sapiens_hsa012120.19478433
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18941613
121Other glycan degradation_Homo sapiens_hsa005110.16612233
122Lysosome_Homo sapiens_hsa041420.14512088
123Tight junction_Homo sapiens_hsa045300.14101183
124Non-homologous end-joining_Homo sapiens_hsa034500.13764863
125Oocyte meiosis_Homo sapiens_hsa041140.13274477
126Melanoma_Homo sapiens_hsa052180.11626512
127One carbon pool by folate_Homo sapiens_hsa006700.11597617
128beta-Alanine metabolism_Homo sapiens_hsa004100.11030109

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