CNIH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.55435757
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.41964554
3locomotory exploration behavior (GO:0035641)6.33162643
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.03875987
5vocalization behavior (GO:0071625)5.71027065
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.69987729
7* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.41372649
8synaptic vesicle exocytosis (GO:0016079)5.31298488
9glutamate secretion (GO:0014047)5.27396200
10* regulation of glutamate receptor signaling pathway (GO:1900449)5.18805112
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.11965443
12exploration behavior (GO:0035640)5.07464958
13protein localization to synapse (GO:0035418)5.06636434
14regulation of synapse structural plasticity (GO:0051823)5.05374127
15regulation of neuronal synaptic plasticity (GO:0048168)5.04504417
16regulation of synaptic vesicle exocytosis (GO:2000300)5.03051124
17dendritic spine morphogenesis (GO:0060997)4.95024107
18layer formation in cerebral cortex (GO:0021819)4.92889655
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.86032023
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.83189743
21behavioral response to nicotine (GO:0035095)4.61788038
22regulation of synaptic vesicle transport (GO:1902803)4.55273523
23establishment of mitochondrion localization (GO:0051654)4.46099753
24neuron cell-cell adhesion (GO:0007158)4.41536535
25nucleobase catabolic process (GO:0046113)4.39633351
26neurotransmitter secretion (GO:0007269)4.34019298
27neurotransmitter-gated ion channel clustering (GO:0072578)4.31718536
28long-term memory (GO:0007616)4.14328084
29glutamate receptor signaling pathway (GO:0007215)4.10393056
30regulation of dendritic spine morphogenesis (GO:0061001)4.09722499
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09619155
32positive regulation of synapse maturation (GO:0090129)4.06780054
33* synaptic transmission, glutamatergic (GO:0035249)4.06731635
34positive regulation of membrane potential (GO:0045838)4.02944202
35establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.95576559
36mitochondrion transport along microtubule (GO:0047497)3.95576559
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91144873
38neuronal action potential propagation (GO:0019227)3.91036942
39proline transport (GO:0015824)3.87387935
40neuron recognition (GO:0008038)3.85069049
41regulation of synaptic plasticity (GO:0048167)3.83160866
42auditory behavior (GO:0031223)3.77533266
43dendritic spine organization (GO:0097061)3.74659645
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73694107
45neuromuscular process controlling balance (GO:0050885)3.73501936
46cerebellar Purkinje cell differentiation (GO:0021702)3.71949238
47dendrite morphogenesis (GO:0048813)3.69844333
48axonal fasciculation (GO:0007413)3.69353036
49substrate-independent telencephalic tangential migration (GO:0021826)3.68262007
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.68262007
51* neuron-neuron synaptic transmission (GO:0007270)3.68026688
52gamma-aminobutyric acid transport (GO:0015812)3.67945123
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.67029025
54regulation of postsynaptic membrane potential (GO:0060078)3.65928221
55central nervous system myelination (GO:0022010)3.64664136
56axon ensheathment in central nervous system (GO:0032291)3.64664136
57activation of protein kinase A activity (GO:0034199)3.63530239
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.59983064
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58947221
60positive regulation of dendritic spine development (GO:0060999)3.57400332
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.53910161
62neuromuscular synaptic transmission (GO:0007274)3.50090337
63response to auditory stimulus (GO:0010996)3.47597849
64postsynaptic membrane organization (GO:0001941)3.42965754
65axon extension (GO:0048675)3.42744724
66transmission of nerve impulse (GO:0019226)3.42479709
67regulation of dendritic spine development (GO:0060998)3.40479843
68presynaptic membrane organization (GO:0097090)3.40347638
69cellular potassium ion homeostasis (GO:0030007)3.40161929
70cell migration in hindbrain (GO:0021535)3.40156629
71cell communication by electrical coupling (GO:0010644)3.36666305
72synaptic vesicle endocytosis (GO:0048488)3.36558096
73neurotransmitter transport (GO:0006836)3.36004080
74regulation of neurotransmitter secretion (GO:0046928)3.35242401
75sodium ion export (GO:0071436)3.34955130
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33907482
77prepulse inhibition (GO:0060134)3.33448950
78neurofilament cytoskeleton organization (GO:0060052)3.30936209
79regulation of vesicle fusion (GO:0031338)3.30489009
80central nervous system projection neuron axonogenesis (GO:0021952)3.28717248
81long-term synaptic potentiation (GO:0060291)3.28573558
82positive regulation of neurotransmitter secretion (GO:0001956)3.28306091
83behavioral defense response (GO:0002209)3.28226652
84behavioral fear response (GO:0001662)3.28226652
85neuronal ion channel clustering (GO:0045161)3.27955376
86mechanosensory behavior (GO:0007638)3.27198461
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.26656131
88regulation of ARF protein signal transduction (GO:0032012)3.26328119
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22909666
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19316999
91adult walking behavior (GO:0007628)3.19000327
92regulation of neurotransmitter levels (GO:0001505)3.18048473
93learning (GO:0007612)3.17541603
94presynaptic membrane assembly (GO:0097105)3.16802503
95innervation (GO:0060384)3.16210958
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15391362
97cerebellar Purkinje cell layer development (GO:0021680)3.14185053
98positive regulation of neurotransmitter transport (GO:0051590)3.12673534
99regulation of female receptivity (GO:0045924)3.12366932
100dopamine receptor signaling pathway (GO:0007212)3.10079058
101membrane depolarization (GO:0051899)3.09296395
102pyrimidine nucleobase catabolic process (GO:0006208)3.08882519
103intraspecies interaction between organisms (GO:0051703)3.08666938
104social behavior (GO:0035176)3.08666938
105regulation of neurotransmitter transport (GO:0051588)3.08363936
106clathrin coat assembly (GO:0048268)3.08142724
107vesicle transport along microtubule (GO:0047496)3.04808477
108regulation of synaptic transmission (GO:0050804)3.04706884
109regulation of synapse maturation (GO:0090128)3.03305871
110positive regulation of synaptic transmission (GO:0050806)3.00166356
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99730118
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99458597
113neuron projection extension (GO:1990138)2.98199971
114fear response (GO:0042596)2.98097706
115negative regulation of microtubule polymerization (GO:0031115)2.97880840
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.97166908
117neuromuscular process (GO:0050905)2.96569136
118positive regulation of synapse assembly (GO:0051965)2.96109182
119cerebellar granule cell differentiation (GO:0021707)2.95026659
120chemosensory behavior (GO:0007635)2.92745160
121synapse assembly (GO:0007416)2.92199499
122cerebral cortex neuron differentiation (GO:0021895)2.89528897
123spinal cord development (GO:0021510)2.86267005
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84825880
125spinal cord association neuron differentiation (GO:0021527)2.80301432
126cell differentiation in hindbrain (GO:0021533)2.79477669
127dendrite development (GO:0016358)2.75196871
128membrane depolarization during action potential (GO:0086010)2.74531587
129potassium ion homeostasis (GO:0055075)2.73628232
130synapse organization (GO:0050808)2.69835743
131retinal ganglion cell axon guidance (GO:0031290)2.69585292
132synaptic transmission, cholinergic (GO:0007271)2.69318281
133negative regulation of axonogenesis (GO:0050771)2.68835978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.53012668
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34408339
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.24440814
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19147483
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06406126
6RARB_27405468_Chip-Seq_BRAIN_Mouse3.05043388
7GBX2_23144817_ChIP-Seq_PC3_Human2.94529754
8REST_21632747_ChIP-Seq_MESCs_Mouse2.94027536
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88237625
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88237625
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84693304
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.69889960
13DROSHA_22980978_ChIP-Seq_HELA_Human2.65406189
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64613571
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63637969
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61465377
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61272697
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53036703
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.52878038
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.51288248
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.46340808
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45527806
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43366436
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41557491
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.36241105
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27754334
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.27331110
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22669527
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89958612
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.82068890
31AR_21572438_ChIP-Seq_LNCaP_Human1.79442539
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59407574
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.55474029
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54139833
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53346269
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51585335
37KDM2B_26808549_Chip-Seq_K562_Human1.45748392
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43116582
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.42566828
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42310269
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.38999264
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38640399
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36163754
44ZNF274_21170338_ChIP-Seq_K562_Hela1.35645246
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.35401852
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35072037
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33310132
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30698586
49SMAD4_21799915_ChIP-Seq_A2780_Human1.27716701
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25402849
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23652608
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21682555
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.18894663
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17555587
55AR_19668381_ChIP-Seq_PC3_Human1.16778487
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16741984
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16218768
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15738409
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14314565
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13287891
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12836052
62* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12649400
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11873216
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11109625
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.09481287
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09184027
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06750572
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.06583973
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06351490
70CTCF_27219007_Chip-Seq_Bcells_Human1.06072052
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04182175
72AR_25329375_ChIP-Seq_VCAP_Human1.03873556
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02969930
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01152337
75OCT4_19829295_ChIP-Seq_ESCs_Human0.99539443
76P68_20966046_ChIP-Seq_HELA_Human0.99235586
77TET1_21490601_ChIP-Seq_MESCs_Mouse0.98450931
78* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98424407
79YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97904729
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97471148
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96886050
82* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96588124
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96141693
84RNF2_27304074_Chip-Seq_NSC_Mouse0.96097744
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95474036
86* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.95401520
87STAT3_23295773_ChIP-Seq_U87_Human0.94565563
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94037901
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94037901
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93963980
91P300_19829295_ChIP-Seq_ESCs_Human0.93911114
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93500286
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.92926812
94* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92476507
95TAF15_26573619_Chip-Seq_HEK293_Human0.92334350
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91067309
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.91022398
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90552605
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90259502
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.89410680
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87486695
102IGF1R_20145208_ChIP-Seq_DFB_Human0.87381608
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87322721
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.87271616
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87241256
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.86244934
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85896879
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84210754
109AHR_22903824_ChIP-Seq_MCF-7_Human0.83924941
110* LXR_22292898_ChIP-Seq_THP-1_Human0.82946345
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82595872
112TCF4_23295773_ChIP-Seq_U87_Human0.81482278
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.80831373
114SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80553535
115DPY_21335234_ChIP-Seq_ESCs_Mouse0.80138957
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80129490
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79350495
118* CREB1_26743006_Chip-Seq_LNCaP_Human0.78746236
119KLF4_19829295_ChIP-Seq_ESCs_Human0.78564732
120SMC4_20622854_ChIP-Seq_HELA_Human0.78008348
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77778201
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77353188
123MYC_27129775_Chip-Seq_CORNEA_Mouse0.77243786
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76717517
125SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.76059411
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75616790
127* KDM2B_26808549_Chip-Seq_JURKAT_Human0.75398195
128* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.74935936
129MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.73018610
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72524676
131SMAD4_21741376_ChIP-Seq_ESCs_Human0.72000675
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71054228
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69507644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.75523128
2MP0003880_abnormal_central_pattern4.70741518
3MP0003635_abnormal_synaptic_transmissio4.40582768
4MP0004270_analgesia3.91215323
5MP0002063_abnormal_learning/memory/cond3.66233359
6MP0009745_abnormal_behavioral_response3.42313625
7MP0002064_seizures3.05670089
8MP0002822_catalepsy3.02252730
9MP0005423_abnormal_somatic_nervous2.93635834
10MP0002572_abnormal_emotion/affect_behav2.81449674
11MP0001968_abnormal_touch/_nociception2.79738064
12MP0002734_abnormal_mechanical_nocicepti2.57817635
13MP0009046_muscle_twitch2.53083361
14MP0001486_abnormal_startle_reflex2.52144318
15MP0003121_genomic_imprinting2.47889181
16MP0002272_abnormal_nervous_system2.34404344
17MP0000778_abnormal_nervous_system2.16045803
18MP0009780_abnormal_chondrocyte_physiolo2.10669841
19MP0002735_abnormal_chemical_nociception2.09599002
20MP0004858_abnormal_nervous_system2.07291027
21MP0001440_abnormal_grooming_behavior2.05783837
22MP0002733_abnormal_thermal_nociception2.04302122
23MP0004811_abnormal_neuron_physiology2.03069845
24MP0002736_abnormal_nociception_after1.99164247
25MP0001501_abnormal_sleep_pattern1.95493705
26MP0009379_abnormal_foot_pigmentation1.94674306
27MP0001970_abnormal_pain_threshold1.93114030
28MP0003329_amyloid_beta_deposits1.89362115
29MP0002184_abnormal_innervation1.84725283
30MP0002557_abnormal_social/conspecific_i1.83128443
31MP0002909_abnormal_adrenal_gland1.81166658
32MP0002653_abnormal_ependyma_morphology1.79114950
33MP0008569_lethality_at_weaning1.77262872
34MP0002067_abnormal_sensory_capabilities1.70003212
35MP0000955_abnormal_spinal_cord1.67437901
36MP0004885_abnormal_endolymph1.66503328
37MP0004924_abnormal_behavior1.63358867
38MP0005386_behavior/neurological_phenoty1.63358867
39MP0008877_abnormal_DNA_methylation1.59012791
40MP0003787_abnormal_imprinting1.57007940
41MP0006276_abnormal_autonomic_nervous1.54179418
42MP0001984_abnormal_olfaction1.53312832
43MP0002882_abnormal_neuron_morphology1.49477711
44MP0003879_abnormal_hair_cell1.44962568
45MP0005645_abnormal_hypothalamus_physiol1.44628026
46MP0005646_abnormal_pituitary_gland1.44139901
47MP0002066_abnormal_motor_capabilities/c1.41998688
48MP0003122_maternal_imprinting1.40991140
49MP0004133_heterotaxia1.26825846
50MP0003633_abnormal_nervous_system1.26754617
51MP0001529_abnormal_vocalization1.26510035
52MP0001905_abnormal_dopamine_level1.25407449
53MP0002152_abnormal_brain_morphology1.24838492
54MP0001348_abnormal_lacrimal_gland1.24042129
55MP0003890_abnormal_embryonic-extraembry1.19871751
56MP0001502_abnormal_circadian_rhythm1.19521595
57MP0008789_abnormal_olfactory_epithelium1.16686996
58MP0003075_altered_response_to1.14725942
59MP0002163_abnormal_gland_morphology1.14673451
60MP0000569_abnormal_digit_pigmentation1.13074535
61MP0008961_abnormal_basal_metabolism1.10998503
62MP0003631_nervous_system_phenotype1.06173857
63MP0001485_abnormal_pinna_reflex1.02559612
64MP0002069_abnormal_eating/drinking_beha1.01924097
65MP0001986_abnormal_taste_sensitivity1.01326941
66MP0002160_abnormal_reproductive_system1.00077148
67MP0000751_myopathy0.99313317
68MP0003283_abnormal_digestive_organ0.98186897
69MP0004142_abnormal_muscle_tone0.97246436
70MP0006072_abnormal_retinal_apoptosis0.95240195
71MP0001177_atelectasis0.94633775
72MP0005394_taste/olfaction_phenotype0.91709012
73MP0005499_abnormal_olfactory_system0.91709012
74MP0000026_abnormal_inner_ear0.91586714
75MP0008872_abnormal_physiological_respon0.87454181
76MP0003136_yellow_coat_color0.85926236
77MP0003942_abnormal_urinary_system0.85672577
78MP0008874_decreased_physiological_sensi0.84231187
79MP0000631_abnormal_neuroendocrine_gland0.82482069
80MP0003938_abnormal_ear_development0.81837889
81MP0003119_abnormal_digestive_system0.81162036
82MP0000604_amyloidosis0.81121610
83MP0003634_abnormal_glial_cell0.80911647
84MP0000566_synostosis0.80388532
85MP0003861_abnormal_nervous_system0.78284333
86MP0002229_neurodegeneration0.77821586
87MP0005195_abnormal_posterior_eye0.77351202
88MP0004085_abnormal_heartbeat0.76636706
89MP0000049_abnormal_middle_ear0.75581693
90MP0005535_abnormal_body_temperature0.73649425
91MP0000534_abnormal_ureter_morphology0.72462105
92MP0005167_abnormal_blood-brain_barrier0.72221061
93MP0010386_abnormal_urinary_bladder0.71943034
94MP0002752_abnormal_somatic_nervous0.71529423
95MP0010234_abnormal_vibrissa_follicle0.71498322
96MP0003690_abnormal_glial_cell0.71461252
97MP0003632_abnormal_nervous_system0.70831955
98MP0002638_abnormal_pupillary_reflex0.69933994
99MP0001188_hyperpigmentation0.69475508
100MP0003137_abnormal_impulse_conducting0.68893838
101MP0004742_abnormal_vestibular_system0.68432330
102MP0001299_abnormal_eye_distance/0.68367421
103MP0001963_abnormal_hearing_physiology0.68207167
104MP0003315_abnormal_perineum_morphology0.67793150
105MP0004510_myositis0.66480325
106MP0002090_abnormal_vision0.66192540
107MP0000920_abnormal_myelination0.65800639
108MP0002928_abnormal_bile_duct0.65759285
109MP0000013_abnormal_adipose_tissue0.63833471
110MP0004130_abnormal_muscle_cell0.63799578
111MP0005253_abnormal_eye_physiology0.63781383
112MP0005379_endocrine/exocrine_gland_phen0.63029960
113MP0005623_abnormal_meninges_morphology0.62117305
114MP0004233_abnormal_muscle_weight0.61793104
115MP0002081_perinatal_lethality0.60306433
116MP0005187_abnormal_penis_morphology0.59811821
117MP0002876_abnormal_thyroid_physiology0.58633607
118MP0002234_abnormal_pharynx_morphology0.58523192
119MP0002089_abnormal_postnatal_growth/wei0.58401379
120MP0001664_abnormal_digestion0.57568830
121MP0006292_abnormal_olfactory_placode0.57153165
122MP0005551_abnormal_eye_electrophysiolog0.56735816
123MP0010769_abnormal_survival0.55475668
124MP0003123_paternal_imprinting0.55030677
125MP0004145_abnormal_muscle_electrophysio0.54164068
126MP0005409_darkened_coat_color0.53198748
127MP0001943_abnormal_respiration0.52617262
128MP0002082_postnatal_lethality0.52157898
129MP0010770_preweaning_lethality0.52157898

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.90295221
2Focal motor seizures (HP:0011153)6.79070962
3Focal seizures (HP:0007359)5.28613248
4Visual hallucinations (HP:0002367)5.17689456
5Epileptic encephalopathy (HP:0200134)4.24353440
6Supranuclear gaze palsy (HP:0000605)3.97446193
7Ankle clonus (HP:0011448)3.94032235
8Progressive cerebellar ataxia (HP:0002073)3.92570885
9Impaired vibration sensation in the lower limbs (HP:0002166)3.73853068
10Action tremor (HP:0002345)3.69857118
11Mutism (HP:0002300)3.64098415
12Febrile seizures (HP:0002373)3.57400437
13Atonic seizures (HP:0010819)3.48397262
14Depression (HP:0000716)3.47462416
15Papilledema (HP:0001085)3.45894525
16Abnormality of the lower motor neuron (HP:0002366)3.45601046
17Poor eye contact (HP:0000817)3.41954911
18Generalized tonic-clonic seizures (HP:0002069)3.39793909
19Absence seizures (HP:0002121)3.38723831
20Broad-based gait (HP:0002136)3.31602270
21Urinary bladder sphincter dysfunction (HP:0002839)3.20256982
22Abnormal eating behavior (HP:0100738)3.18037272
23Dialeptic seizures (HP:0011146)3.12749897
24Amblyopia (HP:0000646)3.11555891
25Urinary urgency (HP:0000012)3.08721065
26Torticollis (HP:0000473)3.05729498
27Impaired social interactions (HP:0000735)3.04879224
28Abnormal social behavior (HP:0012433)3.04879224
29Anxiety (HP:0000739)3.02939415
30Megalencephaly (HP:0001355)2.99350723
31Focal dystonia (HP:0004373)2.96876218
32Hepatoblastoma (HP:0002884)2.95321469
33Postural instability (HP:0002172)2.87025557
34Dysmetria (HP:0001310)2.87014214
35Genetic anticipation (HP:0003743)2.85173643
36Dysdiadochokinesis (HP:0002075)2.79682283
37Spastic gait (HP:0002064)2.78872902
38Excessive salivation (HP:0003781)2.77663403
39Drooling (HP:0002307)2.77663403
40Gait imbalance (HP:0002141)2.72806440
41Annular pancreas (HP:0001734)2.72193470
42Neurofibrillary tangles (HP:0002185)2.72138106
43Cerebral inclusion bodies (HP:0100314)2.70751145
44Insomnia (HP:0100785)2.69727487
45Stereotypic behavior (HP:0000733)2.68608602
46Gaze-evoked nystagmus (HP:0000640)2.68029106
47Hyperthyroidism (HP:0000836)2.66547484
48Amyotrophic lateral sclerosis (HP:0007354)2.65657351
49Truncal ataxia (HP:0002078)2.62460629
50Limb dystonia (HP:0002451)2.60305863
51Polyphagia (HP:0002591)2.59225786
52Hemiparesis (HP:0001269)2.58606299
53Pointed chin (HP:0000307)2.56492572
54Craniofacial dystonia (HP:0012179)2.56486212
55Obstructive sleep apnea (HP:0002870)2.51966517
56Abnormal pancreas size (HP:0012094)2.49083423
57Ventricular fibrillation (HP:0001663)2.48163093
58Bradykinesia (HP:0002067)2.47752132
59Intention tremor (HP:0002080)2.44435675
60Apathy (HP:0000741)2.42661217
61Anomalous pulmonary venous return (HP:0010772)2.40642087
62Status epilepticus (HP:0002133)2.40476439
63Impaired smooth pursuit (HP:0007772)2.39586002
64Progressive inability to walk (HP:0002505)2.36476417
65Abnormality of binocular vision (HP:0011514)2.34827149
66Diplopia (HP:0000651)2.34827149
67Impaired vibratory sensation (HP:0002495)2.32998552
68Epileptiform EEG discharges (HP:0011182)2.32445380
69Hyperventilation (HP:0002883)2.32354026
70Lower limb muscle weakness (HP:0007340)2.32122786
71Insidious onset (HP:0003587)2.30951103
72Termporal pattern (HP:0011008)2.30951103
73Molar tooth sign on MRI (HP:0002419)2.29419650
74Abnormality of midbrain morphology (HP:0002418)2.29419650
75Abnormality of the corticospinal tract (HP:0002492)2.29252917
76Congenital malformation of the right heart (HP:0011723)2.28806842
77Double outlet right ventricle (HP:0001719)2.28806842
78EEG with generalized epileptiform discharges (HP:0011198)2.26590601
79Hypsarrhythmia (HP:0002521)2.23404735
80Agitation (HP:0000713)2.22551448
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.22400106
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22400106
83Hemiplegia (HP:0002301)2.19790760
84Diminished motivation (HP:0000745)2.17640841
85Pachygyria (HP:0001302)2.17302817
86Abnormality of the labia minora (HP:0012880)2.16268271
87Diastasis recti (HP:0001540)2.13428934
88Fetal akinesia sequence (HP:0001989)2.13334924
89Bundle branch block (HP:0011710)2.11589454
90Abnormality of ocular smooth pursuit (HP:0000617)2.08628426
91Sleep apnea (HP:0010535)2.08352541
92Medial flaring of the eyebrow (HP:0010747)2.08228576
93Hypogonadotrophic hypogonadism (HP:0000044)2.07040294
94Morphological abnormality of the pyramidal tract (HP:0002062)2.07023115
95Poor suck (HP:0002033)2.06988089
96Scanning speech (HP:0002168)2.06663205
97Inappropriate behavior (HP:0000719)2.06649372
98Abnormality of the pulmonary veins (HP:0011718)2.01445131
99Ankyloglossia (HP:0010296)2.00417560
100Spastic tetraplegia (HP:0002510)1.99570051
101Deep palmar crease (HP:0006191)1.98436469
102Restlessness (HP:0000711)1.98338988
103Incomplete penetrance (HP:0003829)1.97551383
104Congenital primary aphakia (HP:0007707)1.96465894
105Clonus (HP:0002169)1.96291805
106Akinesia (HP:0002304)1.94143025
107Lower limb asymmetry (HP:0100559)1.93832762
108Lissencephaly (HP:0001339)1.92796815
109Nephrogenic diabetes insipidus (HP:0009806)1.92535769
110Pancreatic fibrosis (HP:0100732)1.91950833
111Hyperacusis (HP:0010780)1.91726274
112Supernumerary spleens (HP:0009799)1.91641882
113Nephronophthisis (HP:0000090)1.91363042
114Cerebral hypomyelination (HP:0006808)1.91340373
115Turricephaly (HP:0000262)1.90978777
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.88905854
117Absent speech (HP:0001344)1.88220074
118Delusions (HP:0000746)1.88208611
119Rib fusion (HP:0000902)1.87780959
120Failure to thrive in infancy (HP:0001531)1.87337046
121Lower limb amyotrophy (HP:0007210)1.87219533
122Abnormal EKG (HP:0003115)1.86814871
123Generalized myoclonic seizures (HP:0002123)1.86584261
124Growth hormone deficiency (HP:0000824)1.86430428
125Retinal dysplasia (HP:0007973)1.86148815
126Asplenia (HP:0001746)1.86025416
127Rapidly progressive (HP:0003678)1.85032949
128Anosmia (HP:0000458)1.83898000
129Inability to walk (HP:0002540)1.83059531
130Truncus arteriosus (HP:0001660)1.82590869
131Abnormal respiratory epithelium morphology (HP:0012253)1.82180839
132Abnormal respiratory motile cilium morphology (HP:0005938)1.82180839
133Hypoventilation (HP:0002791)1.81617655
134Elfin facies (HP:0004428)1.81197934
135Hypoplasia of the corpus callosum (HP:0002079)1.81033724
136Abnormality of salivation (HP:0100755)1.78532870
137Neuronal loss in central nervous system (HP:0002529)1.78385285
138Specific learning disability (HP:0001328)1.76976294
139Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76720669
140Hypoplasia of the brainstem (HP:0002365)1.76720669
141Septo-optic dysplasia (HP:0100842)1.75955539
142Oligodactyly (hands) (HP:0001180)1.75841610
143Neoplasm of the adrenal cortex (HP:0100641)1.74867873
144Hypercalciuria (HP:0002150)1.74739848
145Rigidity (HP:0002063)1.74449157
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70923370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.63653769
2NTRK34.29031517
3MARK14.24257188
4MAP3K94.07109204
5STK163.40703356
6MINK12.88552181
7DAPK22.64438885
8PRKD32.61479667
9MAP3K42.53407179
10KSR22.43449620
11PAK62.39953822
12NTRK22.25118695
13KSR12.14525448
14MAP2K72.00664568
15CAMKK11.97285195
16CDK51.66371460
17EPHB21.61724312
18NTRK11.58776151
19SIK21.58683604
20DAPK11.55243486
21MAP3K111.54986610
22MAP2K41.49748459
23TYRO31.45848601
24WNK41.45645196
25MAPK131.44202761
26MAP3K121.41493796
27PRPF4B1.40132846
28MAP3K21.34442982
29ARAF1.33094884
30PHKG21.31114858
31PHKG11.31114858
32UHMK11.29116071
33RIPK41.24501622
34TNIK1.22621892
35LATS21.20032620
36PRKCG1.19750940
37STK381.19647730
38TAOK11.18154720
39FES1.17694367
40PLK21.14174382
41GRK51.08402663
42CDK181.02895659
43CDK191.02103608
44MAP3K131.01325924
45CDK151.00387769
46MARK20.97951140
47CAMK10.97602263
48CDK140.96411671
49MAPK150.95449217
50DYRK1B0.92263319
51CDK11A0.88625349
52RAF10.88509019
53BRAF0.87724582
54STK110.86721932
55ALK0.84615569
56PAK30.84142175
57CAMK2A0.82606481
58CAMK1D0.81733901
59CAMK1G0.81244851
60RET0.81125554
61LMTK20.80881760
62PRKCH0.78674389
63DYRK1A0.76567227
64CSNK1G20.74064436
65SGK2230.73997310
66SGK4940.73997310
67PTK2B0.71600241
68PNCK0.70709463
69CAMK2B0.70309721
70CASK0.68076701
71WNK10.67020356
72PRKCZ0.66786125
73PDK10.66068114
74BCR0.63769705
75DYRK20.59920553
76SGK10.59663863
77NEK10.59494363
78CSNK1E0.59406349
79CSNK1G30.59002828
80ERBB30.58904578
81DYRK30.57663124
82PDPK10.57611527
83CAMKK20.57410788
84MAP3K70.57398153
85MAPK120.56004842
86PINK10.54982259
87CAMK40.53519261
88BRSK10.52455762
89SGK30.51805767
90MAP3K10.49805665
91SCYL20.49243545
92NME10.48760286
93ERBB20.48319511
94FYN0.48296933
95PRKACA0.48058992
96SGK20.47840829
97CSNK1A1L0.46279559
98RPS6KA20.46080252
99WNK30.45773434
100RPS6KA30.45387441
101ICK0.45042001
102AURKA0.43691829
103DAPK30.43452236
104INSRR0.41824254
105LIMK10.41778107
106FER0.41544643
107DMPK0.41375671
108DDR20.39750829
109CDC42BPA0.38795808
110MAP2K10.38253020
111MAPK100.37488321
112RIPK10.37153909
113MAPK80.36307706
114CSNK1D0.35512981
115PKN10.35210581
116PRKDC0.35122633
117ADRBK20.34597569
118SIK30.34368274
119BMPR20.34170154
120MAP3K60.33339206
121GSK3B0.33278734
122OXSR10.32856863
123PRKG10.32460241
124PRKD20.32051316
125PRKCE0.31808249
126CSNK1A10.31451575
127FGFR20.31263995
128PRKCI0.31034393
129CAMK2G0.30931087
130PRKCA0.30779999
131CSNK1G10.28810973
132ABL20.26921432
133MAPK140.26306226

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.30195189
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16064970
3Olfactory transduction_Homo sapiens_hsa047402.95577312
4Circadian entrainment_Homo sapiens_hsa047132.73251135
5Long-term potentiation_Homo sapiens_hsa047202.70755412
6Glutamatergic synapse_Homo sapiens_hsa047242.59085509
7GABAergic synapse_Homo sapiens_hsa047272.57123231
8Amphetamine addiction_Homo sapiens_hsa050312.49007540
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44468036
10Morphine addiction_Homo sapiens_hsa050322.38928909
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32193938
12Dopaminergic synapse_Homo sapiens_hsa047282.21809984
13Cholinergic synapse_Homo sapiens_hsa047252.05266284
14Salivary secretion_Homo sapiens_hsa049702.03500725
15Insulin secretion_Homo sapiens_hsa049111.95492225
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93317949
17Gastric acid secretion_Homo sapiens_hsa049711.89728001
18Oxidative phosphorylation_Homo sapiens_hsa001901.74303331
19Cocaine addiction_Homo sapiens_hsa050301.74167057
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73995556
21Oxytocin signaling pathway_Homo sapiens_hsa049211.71737971
22Long-term depression_Homo sapiens_hsa047301.59236324
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57969655
24GnRH signaling pathway_Homo sapiens_hsa049121.55649367
25Renin secretion_Homo sapiens_hsa049241.55258806
26Parkinsons disease_Homo sapiens_hsa050121.54011001
27Gap junction_Homo sapiens_hsa045401.49917507
28Calcium signaling pathway_Homo sapiens_hsa040201.49758629
29Serotonergic synapse_Homo sapiens_hsa047261.47078103
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46608442
31Taste transduction_Homo sapiens_hsa047421.40860945
32Axon guidance_Homo sapiens_hsa043601.40460542
33Glioma_Homo sapiens_hsa052141.39648896
34Alzheimers disease_Homo sapiens_hsa050101.39091945
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33213215
36cAMP signaling pathway_Homo sapiens_hsa040241.23899188
37Estrogen signaling pathway_Homo sapiens_hsa049151.22091964
38Type II diabetes mellitus_Homo sapiens_hsa049301.20643388
39Melanogenesis_Homo sapiens_hsa049161.18111014
40ErbB signaling pathway_Homo sapiens_hsa040121.17815956
41Nitrogen metabolism_Homo sapiens_hsa009101.11604311
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09913402
43Huntingtons disease_Homo sapiens_hsa050161.07764068
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06565823
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05078891
46Oocyte meiosis_Homo sapiens_hsa041141.02855458
47Collecting duct acid secretion_Homo sapiens_hsa049661.02801684
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99396891
49Sulfur relay system_Homo sapiens_hsa041220.97924874
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.96987795
51Ribosome_Homo sapiens_hsa030100.94364258
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89204876
53VEGF signaling pathway_Homo sapiens_hsa043700.87575576
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.86819389
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86153209
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85289851
57Notch signaling pathway_Homo sapiens_hsa043300.84622753
58Choline metabolism in cancer_Homo sapiens_hsa052310.84317662
59Cardiac muscle contraction_Homo sapiens_hsa042600.80427198
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79265420
61Dorso-ventral axis formation_Homo sapiens_hsa043200.78230641
62Hedgehog signaling pathway_Homo sapiens_hsa043400.76720972
63Vibrio cholerae infection_Homo sapiens_hsa051100.76515906
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75195925
65Endometrial cancer_Homo sapiens_hsa052130.73472258
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72963749
67Hippo signaling pathway_Homo sapiens_hsa043900.72785919
68Basal cell carcinoma_Homo sapiens_hsa052170.72267041
69MAPK signaling pathway_Homo sapiens_hsa040100.71874898
70Thyroid hormone synthesis_Homo sapiens_hsa049180.71862762
71mTOR signaling pathway_Homo sapiens_hsa041500.69608701
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69605720
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69108332
74Dilated cardiomyopathy_Homo sapiens_hsa054140.69043400
75Pancreatic secretion_Homo sapiens_hsa049720.67941054
76Vitamin B6 metabolism_Homo sapiens_hsa007500.67830824
77Non-small cell lung cancer_Homo sapiens_hsa052230.67440778
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67055262
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66294121
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66202047
81Alcoholism_Homo sapiens_hsa050340.66079879
82Rap1 signaling pathway_Homo sapiens_hsa040150.65380807
83Endocytosis_Homo sapiens_hsa041440.64542506
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63840672
85Ras signaling pathway_Homo sapiens_hsa040140.63352932
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62055722
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.61596039
88Glucagon signaling pathway_Homo sapiens_hsa049220.59937270
89Phototransduction_Homo sapiens_hsa047440.59766961
90Renal cell carcinoma_Homo sapiens_hsa052110.55755406
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54629086
92Wnt signaling pathway_Homo sapiens_hsa043100.53300849
93Prion diseases_Homo sapiens_hsa050200.52871794
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49535095
95Colorectal cancer_Homo sapiens_hsa052100.49455062
96Insulin signaling pathway_Homo sapiens_hsa049100.49437712
97Butanoate metabolism_Homo sapiens_hsa006500.49402541
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49386202
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49234228
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48581879
101Type I diabetes mellitus_Homo sapiens_hsa049400.47456624
102Bile secretion_Homo sapiens_hsa049760.45817204
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44925279
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42797019
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42524517
106Chemokine signaling pathway_Homo sapiens_hsa040620.39345999
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38442292
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36109279
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34717480
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34550626
111Inositol phosphate metabolism_Homo sapiens_hsa005620.33482740
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32758720
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32136957
114Circadian rhythm_Homo sapiens_hsa047100.29431727
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29320275
116Ovarian steroidogenesis_Homo sapiens_hsa049130.29251767
117African trypanosomiasis_Homo sapiens_hsa051430.29039371
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.28943837
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28399309
120Prolactin signaling pathway_Homo sapiens_hsa049170.27392519
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25585388

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