CNIH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)6.98630754
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95285923
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.83175375
4vocalization behavior (GO:0071625)5.82414697
5* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.69223540
6opioid receptor signaling pathway (GO:0038003)5.52714433
7synaptic vesicle exocytosis (GO:0016079)5.51644041
8behavioral response to ethanol (GO:0048149)5.50449384
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.47321415
10protein localization to synapse (GO:0035418)5.43974697
11glutamate secretion (GO:0014047)5.37617940
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.29571996
13neuron cell-cell adhesion (GO:0007158)5.26045682
14negative regulation of cAMP-mediated signaling (GO:0043951)5.20064146
15* regulation of glutamate receptor signaling pathway (GO:1900449)5.17247279
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.08805978
17glutamate receptor signaling pathway (GO:0007215)4.99190475
18locomotory exploration behavior (GO:0035641)4.94247475
19negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.93592787
20synaptic vesicle maturation (GO:0016188)4.89037180
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86017244
22regulation of synaptic vesicle exocytosis (GO:2000300)4.84875045
23presynaptic membrane assembly (GO:0097105)4.73026509
24* synaptic transmission, glutamatergic (GO:0035249)4.69356963
25neuronal action potential propagation (GO:0019227)4.67814533
26adult feeding behavior (GO:0008343)4.66618991
27neurotransmitter-gated ion channel clustering (GO:0072578)4.61035085
28* neuron-neuron synaptic transmission (GO:0007270)4.48991614
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.48873654
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.42011291
31regulation of synaptic vesicle transport (GO:1902803)4.41581647
32presynaptic membrane organization (GO:0097090)4.36533971
33postsynaptic membrane organization (GO:0001941)4.34352589
34regulation of neuronal synaptic plasticity (GO:0048168)4.33810767
35positive regulation of synapse maturation (GO:0090129)4.32264064
36exploration behavior (GO:0035640)4.30627685
37neuron recognition (GO:0008038)4.27115380
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.17642177
39sphingoid metabolic process (GO:0046519)4.13662629
40adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.09643340
41neurotransmitter secretion (GO:0007269)3.98433367
42long-term memory (GO:0007616)3.97157200
43regulation of postsynaptic membrane potential (GO:0060078)3.97002836
44sphingosine metabolic process (GO:0006670)3.96733194
45positive regulation of neurotransmitter secretion (GO:0001956)3.95787830
46axonal fasciculation (GO:0007413)3.95383460
47positive regulation of membrane potential (GO:0045838)3.95300751
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93986262
49regulation of dendritic spine morphogenesis (GO:0061001)3.91669456
50long-term synaptic potentiation (GO:0060291)3.87527024
51regulation of synaptic plasticity (GO:0048167)3.84591531
52piRNA metabolic process (GO:0034587)3.81647824
53retinal cone cell development (GO:0046549)3.81348376
54synaptic vesicle endocytosis (GO:0048488)3.79841508
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.78290544
56regulation of protein glycosylation (GO:0060049)3.75851776
57layer formation in cerebral cortex (GO:0021819)3.74151511
58transmission of nerve impulse (GO:0019226)3.73785538
59dendritic spine morphogenesis (GO:0060997)3.71755743
60regulation of neurotransmitter uptake (GO:0051580)3.70782716
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.65835875
62regulation of synapse maturation (GO:0090128)3.57864999
63response to histamine (GO:0034776)3.55917970
64gamma-aminobutyric acid transport (GO:0015812)3.55714585
65positive regulation of cAMP-mediated signaling (GO:0043950)3.55197113
66regulation of synapse structural plasticity (GO:0051823)3.52830010
67regulation of dendritic spine development (GO:0060998)3.50733136
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.50612999
69regulation of acrosome reaction (GO:0060046)3.49953940
70regulation of female receptivity (GO:0045924)3.49574969
71regulation of glutamate secretion (GO:0014048)3.49552533
72regulation of neurotransmitter secretion (GO:0046928)3.49424075
73glycosphingolipid biosynthetic process (GO:0006688)3.49161046
74lipopolysaccharide biosynthetic process (GO:0009103)3.45656697
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45382100
76behavioral fear response (GO:0001662)3.44895484
77behavioral defense response (GO:0002209)3.44895484
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44475463
79diol metabolic process (GO:0034311)3.44187113
80regulation of vesicle fusion (GO:0031338)3.38215857
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34647448
82proline transport (GO:0015824)3.34110102
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33534918
84positive regulation of neurotransmitter transport (GO:0051590)3.32300399
85neurotransmitter transport (GO:0006836)3.30297192
86female mating behavior (GO:0060180)3.30198291
87positive regulation of dendritic spine development (GO:0060999)3.30158596
88long term synaptic depression (GO:0060292)3.29164375
89membrane depolarization (GO:0051899)3.26142790
90fear response (GO:0042596)3.23512113
91learning (GO:0007612)3.22965760
92cerebellar granule cell differentiation (GO:0021707)3.22563377
93central nervous system projection neuron axonogenesis (GO:0021952)3.22529380
94cellular potassium ion homeostasis (GO:0030007)3.18829965
95dendritic spine organization (GO:0097061)3.16184115
96ether lipid metabolic process (GO:0046485)3.15853862
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13327410
98regulation of synaptic transmission (GO:0050804)3.12716664
99mechanosensory behavior (GO:0007638)3.12188571
100startle response (GO:0001964)3.12070991
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11068301
102positive regulation of synaptic transmission (GO:0050806)3.09442063
103* synaptic transmission (GO:0007268)3.09323528
104glycerophospholipid catabolic process (GO:0046475)3.08770884
105regulation of neurotransmitter transport (GO:0051588)3.08662271
106positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06726212
107synapse assembly (GO:0007416)3.05721493
108negative regulation of mast cell activation (GO:0033004)3.05252663
109neuronal action potential (GO:0019228)3.04895803
110negative regulation of amino acid transport (GO:0051956)3.03302762
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02434611
112positive regulation of synapse assembly (GO:0051965)3.02413572
113regulation of neurotransmitter levels (GO:0001505)3.00181442
114innervation (GO:0060384)2.99891419
115regulation of translational termination (GO:0006449)2.99444641
116negative regulation of calcium ion transport into cytosol (GO:0010523)2.98116211
117dendrite morphogenesis (GO:0048813)2.96075594
118detection of calcium ion (GO:0005513)2.95001750
119glycosphingolipid metabolic process (GO:0006687)2.94827839
120membrane hyperpolarization (GO:0060081)2.94703932
121glomerular visceral epithelial cell development (GO:0072015)2.94649064
122cochlea development (GO:0090102)2.93859090
123membrane depolarization during action potential (GO:0086010)2.91919815
124auditory behavior (GO:0031223)2.91485923
125negative regulation of nitric oxide biosynthetic process (GO:0045019)2.90542385
126synaptic vesicle transport (GO:0048489)2.88067463
127establishment of synaptic vesicle localization (GO:0097480)2.88067463
128peristalsis (GO:0030432)2.85621863
129cellular ketone body metabolic process (GO:0046950)2.84009899
130cilium morphogenesis (GO:0060271)2.82728745
131positive regulation of cardiac muscle cell differentiation (GO:2000727)2.82494490
132detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82485163
133ganglioside metabolic process (GO:0001573)2.78571232
134lipopolysaccharide metabolic process (GO:0008653)2.74859625
135detection of light stimulus involved in sensory perception (GO:0050962)2.67748142
136detection of light stimulus involved in visual perception (GO:0050908)2.67748142
137thrombin receptor signaling pathway (GO:0070493)2.67259726
138glucosamine-containing compound catabolic process (GO:1901072)2.64429933
139tachykinin receptor signaling pathway (GO:0007217)2.62081511
140phasic smooth muscle contraction (GO:0014821)2.60452128
141coenzyme catabolic process (GO:0009109)2.58209683
142regulation of cAMP-mediated signaling (GO:0043949)2.56823388
143ketone body metabolic process (GO:1902224)2.55963878
144righting reflex (GO:0060013)2.55263332
145regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54552179
146serotonin metabolic process (GO:0042428)2.51002351
147sialylation (GO:0097503)2.50964793
148primary amino compound metabolic process (GO:1901160)2.50233387
149response to gravity (GO:0009629)2.49510441
150regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.46119747
151regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.46119747
152glomerular epithelial cell development (GO:0072310)2.45631960
153platelet dense granule organization (GO:0060155)2.43958309
154regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.43796571
155glycolipid metabolic process (GO:0006664)2.43641329
156reflex (GO:0060004)2.42713415
157liposaccharide metabolic process (GO:1903509)2.42460140
158detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42382100
159protein K11-linked deubiquitination (GO:0035871)2.38915580
160regulation of cilium movement (GO:0003352)2.38875446
161rhodopsin mediated signaling pathway (GO:0016056)2.38339970
162negative regulation of cell-matrix adhesion (GO:0001953)2.34843648
163indolalkylamine metabolic process (GO:0006586)2.34147358
164glycerol ether metabolic process (GO:0006662)2.32694755
165regulation of calcium ion-dependent exocytosis (GO:0017158)2.32175255
166regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.31609906
167negative regulation of cation channel activity (GO:2001258)2.30066900
168negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29703206
169positive regulation of meiosis (GO:0045836)2.29642446
170photoreceptor cell maintenance (GO:0045494)2.29123104
171determination of left/right symmetry (GO:0007368)2.29091491
172signal peptide processing (GO:0006465)2.28816923
173response to pheromone (GO:0019236)2.25801637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45223914
2GBX2_23144817_ChIP-Seq_PC3_Human4.23570542
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25597814
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16609021
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16365406
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04443315
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70428848
8REST_21632747_ChIP-Seq_MESCs_Mouse2.61255943
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61100361
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60749924
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60749924
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58305083
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57136687
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.56777935
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42799043
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40635461
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38787624
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37262133
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.21895914
20DROSHA_22980978_ChIP-Seq_HELA_Human2.16192906
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15359142
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13756088
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.13685283
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13601237
25TAF15_26573619_Chip-Seq_HEK293_Human2.13280523
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04322593
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04076483
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02106269
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.01490028
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01272426
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97628194
32AR_21572438_ChIP-Seq_LNCaP_Human1.90669421
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85569148
34SMAD4_21799915_ChIP-Seq_A2780_Human1.84465410
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80133410
36* P300_19829295_ChIP-Seq_ESCs_Human1.77608214
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75917336
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74992701
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64214603
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61152747
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.61138110
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58197789
43CBP_20019798_ChIP-Seq_JUKART_Human1.58197789
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56407484
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.52215759
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52061542
47FUS_26573619_Chip-Seq_HEK293_Human1.50587854
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.50570593
49CJUN_26792858_Chip-Seq_BT549_Human1.49601094
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47020659
51VDR_22108803_ChIP-Seq_LS180_Human1.45985188
52AR_25329375_ChIP-Seq_VCAP_Human1.44606152
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.43142086
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42900993
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42021061
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41806916
57* BCAT_22108803_ChIP-Seq_LS180_Human1.40471455
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.38621656
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37594670
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.37513706
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36187813
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36065458
63SOX2_19829295_ChIP-Seq_ESCs_Human1.35086594
64NANOG_19829295_ChIP-Seq_ESCs_Human1.35086594
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34100089
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33199002
67STAT3_23295773_ChIP-Seq_U87_Human1.31382376
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.31119046
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30838156
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26861243
71ZNF274_21170338_ChIP-Seq_K562_Hela1.26179278
72RNF2_27304074_Chip-Seq_NSC_Mouse1.23336704
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23227881
74* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21195295
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20248226
76TCF4_23295773_ChIP-Seq_U87_Human1.19706008
77* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19528871
78* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18125164
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.17683809
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17336846
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17275355
82* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17136920
83* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16287063
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13723710
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13723710
86IGF1R_20145208_ChIP-Seq_DFB_Human1.13574054
87TP53_18474530_ChIP-ChIP_U2OS_Human1.13385273
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.13342907
89* ERG_21242973_ChIP-ChIP_JURKAT_Human1.13247863
90* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12977803
91* AR_19668381_ChIP-Seq_PC3_Human1.12850278
92* TCF4_22108803_ChIP-Seq_LS180_Human1.12631734
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12546001
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12343200
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12310760
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12004671
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10409346
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10382360
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10369914
100CDX2_22108803_ChIP-Seq_LS180_Human1.10220536
101ER_23166858_ChIP-Seq_MCF-7_Human1.08045518
102* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07937350
103RUNX2_22187159_ChIP-Seq_PCA_Human1.07530171
104* JUN_21703547_ChIP-Seq_K562_Human1.06465347
105AHR_22903824_ChIP-Seq_MCF-7_Human1.06330273
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06246631
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.06186157
108* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06089518
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06084795
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05670031
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04808060
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04750704
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.04064699
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03000391
115BRD4_25478319_ChIP-Seq_HGPS_Human1.02738699
116* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02580180
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02441401
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02266696
119TP53_16413492_ChIP-PET_HCT116_Human1.01292122
120* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01120109
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00833854
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00328025
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.99986296
124* NFE2_27457419_Chip-Seq_LIVER_Mouse0.99419603
125* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99293733
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98899634
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96200316
128* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95803159
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95279723
130* P53_22387025_ChIP-Seq_ESCs_Mouse0.93605333
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.93164824
132KDM2B_26808549_Chip-Seq_REH_Human0.92359459
133RXR_22108803_ChIP-Seq_LS180_Human0.91631598
134* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91244911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.56999332
2MP0003880_abnormal_central_pattern5.81999065
3MP0003635_abnormal_synaptic_transmissio4.24203854
4MP0009745_abnormal_behavioral_response3.62039141
5MP0004270_analgesia3.54826092
6MP0002063_abnormal_learning/memory/cond3.49704642
7MP0001968_abnormal_touch/_nociception3.43434320
8MP0002064_seizures3.22394434
9MP0002572_abnormal_emotion/affect_behav2.98269704
10MP0002736_abnormal_nociception_after2.91329084
11MP0009046_muscle_twitch2.80367678
12MP0002735_abnormal_chemical_nociception2.77315772
13MP0002272_abnormal_nervous_system2.68148795
14MP0005503_abnormal_tendon_morphology2.59537802
15MP0001501_abnormal_sleep_pattern2.57245530
16MP0002734_abnormal_mechanical_nocicepti2.55945438
17MP0001486_abnormal_startle_reflex2.47819766
18MP0001440_abnormal_grooming_behavior2.44606996
19MP0005423_abnormal_somatic_nervous2.30722023
20MP0003283_abnormal_digestive_organ2.20410067
21MP0000778_abnormal_nervous_system2.07624938
22MP0002067_abnormal_sensory_capabilities2.07599066
23MP0009780_abnormal_chondrocyte_physiolo1.98020677
24MP0006276_abnormal_autonomic_nervous1.96324758
25MP0002733_abnormal_thermal_nociception1.94012017
26MP0006054_spinal_hemorrhage1.91838957
27MP0001970_abnormal_pain_threshold1.89157723
28MP0003329_amyloid_beta_deposits1.86441726
29MP0002184_abnormal_innervation1.78618279
30MP0009278_abnormal_bone_marrow1.78480670
31MP0002557_abnormal_social/conspecific_i1.73441268
32MP0003879_abnormal_hair_cell1.72330037
33MP0002822_catalepsy1.70109648
34MP0003195_calcinosis1.68989580
35MP0004924_abnormal_behavior1.65426016
36MP0005386_behavior/neurological_phenoty1.65426016
37MP0003950_abnormal_plasma_membrane1.65075939
38MP0003787_abnormal_imprinting1.58837632
39MP0008569_lethality_at_weaning1.58726573
40MP0005646_abnormal_pituitary_gland1.57864089
41MP0004811_abnormal_neuron_physiology1.54689923
42MP0003045_fibrosis1.54612280
43MP0003136_yellow_coat_color1.50369017
44MP0001188_hyperpigmentation1.50295294
45MP0004043_abnormal_pH_regulation1.50238335
46MP0002909_abnormal_adrenal_gland1.47046424
47MP0005167_abnormal_blood-brain_barrier1.46277348
48MP0004858_abnormal_nervous_system1.45543892
49MP0002837_dystrophic_cardiac_calcinosis1.42483397
50MP0000955_abnormal_spinal_cord1.41855511
51MP0005645_abnormal_hypothalamus_physiol1.40046338
52MP0001984_abnormal_olfaction1.39901705
53MP0002066_abnormal_motor_capabilities/c1.37443498
54MP0002882_abnormal_neuron_morphology1.35567173
55MP0000372_irregular_coat_pigmentation1.34790936
56MP0001502_abnormal_circadian_rhythm1.34361270
57MP0002876_abnormal_thyroid_physiology1.34036945
58MP0001905_abnormal_dopamine_level1.32606641
59MP0006072_abnormal_retinal_apoptosis1.31687191
60MP0005257_abnormal_intraocular_pressure1.30680201
61MP0004885_abnormal_endolymph1.30134520
62MP0000681_abnormal_thyroid_gland1.29743837
63MP0003633_abnormal_nervous_system1.29015742
64MP0009764_decreased_sensitivity_to1.27522270
65MP0009053_abnormal_anal_canal1.27214963
66MP0005253_abnormal_eye_physiology1.23985551
67MP0001529_abnormal_vocalization1.18011021
68MP0010386_abnormal_urinary_bladder1.15227182
69MP0003183_abnormal_peptide_metabolism1.12634983
70MP0000749_muscle_degeneration1.11814136
71MP0003631_nervous_system_phenotype1.10333402
72MP0005187_abnormal_penis_morphology1.07365293
73MP0002152_abnormal_brain_morphology1.07168547
74MP0004145_abnormal_muscle_electrophysio1.06725178
75MP0004142_abnormal_muscle_tone1.06020085
76MP0003646_muscle_fatigue1.04952482
77MP0005410_abnormal_fertilization1.03504770
78MP0003172_abnormal_lysosome_physiology1.00919528
79MP0001963_abnormal_hearing_physiology0.98808439
80MP0004742_abnormal_vestibular_system0.93307228
81MP0006292_abnormal_olfactory_placode0.92407059
82MP0003122_maternal_imprinting0.92004645
83MP0008874_decreased_physiological_sensi0.91177307
84MP0009250_abnormal_appendicular_skeleto0.90477767
85MP0005195_abnormal_posterior_eye0.90267070
86MP0004484_altered_response_of0.90234052
87MP0005551_abnormal_eye_electrophysiolog0.90192084
88MP0002069_abnormal_eating/drinking_beha0.89453069
89MP0005171_absent_coat_pigmentation0.87131430
90MP0003191_abnormal_cellular_cholesterol0.86713014
91MP0008872_abnormal_physiological_respon0.86230792
92MP0008877_abnormal_DNA_methylation0.85588688
93MP0001177_atelectasis0.85250744
94MP0002653_abnormal_ependyma_morphology0.84984317
95MP0002168_other_aberrant_phenotype0.84484688
96MP0003937_abnormal_limbs/digits/tail_de0.83610991
97MP0005508_abnormal_skeleton_morphology0.83568201
98MP0002229_neurodegeneration0.83529391
99MP0001986_abnormal_taste_sensitivity0.83112871
100MP0000569_abnormal_digit_pigmentation0.81193669
101MP0000751_myopathy0.80980578
102MP0000604_amyloidosis0.80930906
103MP0002102_abnormal_ear_morphology0.80778697
104MP0004085_abnormal_heartbeat0.80430795
105MP0005409_darkened_coat_color0.79423511
106MP0000358_abnormal_cell_content/0.78861146
107MP0002090_abnormal_vision0.77543452
108MP0004215_abnormal_myocardial_fiber0.77507687
109MP0000631_abnormal_neuroendocrine_gland0.77442493
110MP0002752_abnormal_somatic_nervous0.74953401
111MP0005174_abnormal_tail_pigmentation0.74409415
112MP0005535_abnormal_body_temperature0.73284962
113MP0008775_abnormal_heart_ventricle0.73218028
114MP0000516_abnormal_urinary_system0.73147817
115MP0005367_renal/urinary_system_phenotyp0.73147817
116MP0000230_abnormal_systemic_arterial0.72247180
117MP0003632_abnormal_nervous_system0.71692970
118MP0005310_abnormal_salivary_gland0.71523346
119MP0001664_abnormal_digestion0.71232756
120MP0003638_abnormal_response/metabolism_0.71205353
121MP0004510_myositis0.70523558
122MP0003075_altered_response_to0.70092534
123MP0000026_abnormal_inner_ear0.68830252
124MP0004272_abnormal_basement_membrane0.68557637
125MP0008438_abnormal_cutaneous_collagen0.67412835
126MP0001485_abnormal_pinna_reflex0.64356609
127MP0002638_abnormal_pupillary_reflex0.61156208
128MP0003634_abnormal_glial_cell0.60599869
129MP0005394_taste/olfaction_phenotype0.60127385
130MP0005499_abnormal_olfactory_system0.60127385
131MP0000920_abnormal_myelination0.59977080
132MP0003938_abnormal_ear_development0.59762826
133MP0000015_abnormal_ear_pigmentation0.59360237
134MP0003690_abnormal_glial_cell0.55690276
135MP0003861_abnormal_nervous_system0.54336082
136MP0001943_abnormal_respiration0.51616548
137MP0003137_abnormal_impulse_conducting0.50400452
138MP0010769_abnormal_survival0.50081200
139MP0010770_preweaning_lethality0.49781155
140MP0002082_postnatal_lethality0.49781155
141MP0005623_abnormal_meninges_morphology0.47657604
142MP0010768_mortality/aging0.47425915
143MP0000013_abnormal_adipose_tissue0.47116739

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.60158363
2Thyroid-stimulating hormone excess (HP:0002925)6.22980122
3Focal seizures (HP:0007359)6.18552114
4Myokymia (HP:0002411)6.12629388
5Epileptic encephalopathy (HP:0200134)6.10750538
6Visual hallucinations (HP:0002367)5.64383955
7Atonic seizures (HP:0010819)5.54242778
8Hyperventilation (HP:0002883)5.48295254
9Febrile seizures (HP:0002373)5.38263198
10Absence seizures (HP:0002121)4.61676479
11Broad-based gait (HP:0002136)4.42044600
12Dialeptic seizures (HP:0011146)4.37676411
13Generalized tonic-clonic seizures (HP:0002069)4.25412251
14Intestinal atresia (HP:0011100)4.08344543
15Abnormality of glycolipid metabolism (HP:0010969)4.00588180
16Abnormality of liposaccharide metabolism (HP:0010968)4.00588180
17Abnormality of glycosphingolipid metabolism (HP:0004343)4.00588180
18Progressive cerebellar ataxia (HP:0002073)3.98775305
19Large for gestational age (HP:0001520)3.58416012
20Poor eye contact (HP:0000817)3.53252761
21Excessive salivation (HP:0003781)3.44205017
22Drooling (HP:0002307)3.44205017
23Gaze-evoked nystagmus (HP:0000640)3.44129370
24Amblyopia (HP:0000646)3.43549325
25Poor head control (HP:0002421)3.41199636
26Agitation (HP:0000713)3.35264617
27Mesangial abnormality (HP:0001966)3.25376002
28Cerebral inclusion bodies (HP:0100314)3.20551177
29Absent speech (HP:0001344)3.11251819
30Type II lissencephaly (HP:0007260)3.09509023
31Protruding tongue (HP:0010808)3.08644297
32Abnormal social behavior (HP:0012433)3.02630041
33Impaired social interactions (HP:0000735)3.02630041
34Cerebellar dysplasia (HP:0007033)3.00017287
35Supranuclear gaze palsy (HP:0000605)2.99162845
36Epileptiform EEG discharges (HP:0011182)2.97772624
37Impaired vibration sensation in the lower limbs (HP:0002166)2.95684711
38Dysdiadochokinesis (HP:0002075)2.93092487
39Truncal ataxia (HP:0002078)2.86646829
40Dysmetria (HP:0001310)2.85650225
41Diplopia (HP:0000651)2.85278327
42Abnormality of binocular vision (HP:0011514)2.85278327
43Inability to walk (HP:0002540)2.81605762
44Abnormality of midbrain morphology (HP:0002418)2.79123263
45Molar tooth sign on MRI (HP:0002419)2.79123263
46Neurofibrillary tangles (HP:0002185)2.74353652
47Urinary bladder sphincter dysfunction (HP:0002839)2.72957109
48Dysostosis multiplex (HP:0000943)2.72288421
49Fetal akinesia sequence (HP:0001989)2.71691753
50Action tremor (HP:0002345)2.71006491
51Congenital stationary night blindness (HP:0007642)2.70383145
52Volvulus (HP:0002580)2.69348407
53EEG with generalized epileptiform discharges (HP:0011198)2.69068937
54Anxiety (HP:0000739)2.68374955
55Depression (HP:0000716)2.67668487
56Disproportionate short-trunk short stature (HP:0003521)2.66744591
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66010841
58Abnormality of polysaccharide metabolism (HP:0011012)2.66010841
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66010841
60Hemiparesis (HP:0001269)2.65713942
61Limb dystonia (HP:0002451)2.60998810
62Severe visual impairment (HP:0001141)2.59390446
63Impaired smooth pursuit (HP:0007772)2.59070786
64Abnormal eating behavior (HP:0100738)2.55941704
65Pancreatic cysts (HP:0001737)2.55934557
66Keratoconus (HP:0000563)2.53373395
67Increased corneal curvature (HP:0100692)2.53373395
68Abnormality of the lower motor neuron (HP:0002366)2.52299405
693-Methylglutaconic aciduria (HP:0003535)2.50760518
70Stereotypic behavior (HP:0000733)2.50578673
71Attenuation of retinal blood vessels (HP:0007843)2.49692966
72Abnormality of the aortic arch (HP:0012303)2.46323603
73Hypsarrhythmia (HP:0002521)2.45067147
74Tubular atrophy (HP:0000092)2.40406791
75Abnormality of salivation (HP:0100755)2.39530895
76Blue irides (HP:0000635)2.39360459
77Upper limb muscle weakness (HP:0003484)2.37175494
78Ankle clonus (HP:0011448)2.36481320
79True hermaphroditism (HP:0010459)2.36152837
80Mutism (HP:0002300)2.36144779
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.34619453
82Generalized myoclonic seizures (HP:0002123)2.34085012
83Polyphagia (HP:0002591)2.33544142
84Postural instability (HP:0002172)2.30679973
85Fair hair (HP:0002286)2.30434780
86Hypothermia (HP:0002045)2.28505317
87Large eyes (HP:0001090)2.28013939
88Progressive inability to walk (HP:0002505)2.27256317
89Pancreatic fibrosis (HP:0100732)2.26744235
90Status epilepticus (HP:0002133)2.25707503
91Generalized hypopigmentation of hair (HP:0011358)2.25375067
92Pancreatic islet-cell hyperplasia (HP:0004510)2.24686178
93Scanning speech (HP:0002168)2.24637544
94Genetic anticipation (HP:0003743)2.24623737
95Delusions (HP:0000746)2.24322813
96Urinary glycosaminoglycan excretion (HP:0003541)2.23168081
97Mucopolysacchariduria (HP:0008155)2.23168081
98Inappropriate behavior (HP:0000719)2.22391252
99Thickened helices (HP:0000391)2.22318563
100Spastic gait (HP:0002064)2.21711367
101Dynein arm defect of respiratory motile cilia (HP:0012255)2.20931092
102Absent/shortened dynein arms (HP:0200106)2.20931092
103Follicular hyperkeratosis (HP:0007502)2.19458244
104Bradykinesia (HP:0002067)2.19275171
105Urinary urgency (HP:0000012)2.16659137
106Medial flaring of the eyebrow (HP:0010747)2.15551244
107Papilledema (HP:0001085)2.14292803
108Nephronophthisis (HP:0000090)2.13747148
109Gastrointestinal atresia (HP:0002589)2.13212244
110Increased cerebral lipofuscin (HP:0011813)2.11087383
111Abnormality of ocular smooth pursuit (HP:0000617)2.10718579
112Impaired vibratory sensation (HP:0002495)2.07619254
113Amyotrophic lateral sclerosis (HP:0007354)2.07167837
114Widely spaced teeth (HP:0000687)2.05481535
115Abnormality of the corticospinal tract (HP:0002492)2.05315914
116Bony spicule pigmentary retinopathy (HP:0007737)2.04606032
117Abolished electroretinogram (ERG) (HP:0000550)2.04044715
118Tented upper lip vermilion (HP:0010804)2.03903016
119Congenital sensorineural hearing impairment (HP:0008527)2.03720358
120Insidious onset (HP:0003587)2.01195238
121Termporal pattern (HP:0011008)2.01195238
122Vacuolated lymphocytes (HP:0001922)2.00728183
123Optic nerve hypoplasia (HP:0000609)1.99768991
124Abnormality of macular pigmentation (HP:0008002)1.98246393
125Exotropia (HP:0000577)1.97938188
126Obstructive sleep apnea (HP:0002870)1.97666915
127Gait imbalance (HP:0002141)1.96373807
128Abnormality of the vitreous humor (HP:0004327)1.94814885
129Retinal dysplasia (HP:0007973)1.94497458
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91563511
131Gait ataxia (HP:0002066)1.91389122
132Hyperthyroidism (HP:0000836)1.88820927
133Akinesia (HP:0002304)1.88556896
134Lissencephaly (HP:0001339)1.88391088
135Severe muscular hypotonia (HP:0006829)1.87583959
136Lower limb muscle weakness (HP:0007340)1.87015290
137Abnormal drinking behavior (HP:0030082)1.86264271
138Polydipsia (HP:0001959)1.86264271
139Congenital primary aphakia (HP:0007707)1.85655024
140Hemiplegia (HP:0002301)1.84624895
141Clumsiness (HP:0002312)1.84155034
142Incomplete penetrance (HP:0003829)1.83585024
143Sclerocornea (HP:0000647)1.83074684
144Abnormality of the renal medulla (HP:0100957)1.81826064
145Megalencephaly (HP:0001355)1.81370455
146Gastroesophageal reflux (HP:0002020)1.80650920
147Torticollis (HP:0000473)1.79704350
148Hand muscle atrophy (HP:0009130)1.79395954
149Intention tremor (HP:0002080)1.79209365
150Intellectual disability, severe (HP:0010864)1.79075896
151Increased CSF protein (HP:0002922)1.78461164
152Psychosis (HP:0000709)1.77554350
153Sleep apnea (HP:0010535)1.77212613
154Focal dystonia (HP:0004373)1.77065292
155Neonatal respiratory distress (HP:0002643)1.75796191
156Abnormal ciliary motility (HP:0012262)1.75558408
157Absent frontal sinuses (HP:0002688)1.75449099
158Dysmetric saccades (HP:0000641)1.74531927
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71823238
160Esotropia (HP:0000565)1.68264101
161Abnormal hair whorl (HP:0010721)1.68196769
162Specific learning disability (HP:0001328)1.66774712
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66425556
164Metaphyseal dysplasia (HP:0100255)1.66292775
165Degeneration of the lateral corticospinal tracts (HP:0002314)1.65514747
166Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65514747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.39607755
2ADRBK26.29528350
3EPHA45.38595610
4NTRK34.64810291
5CASK3.82777804
6MAP3K93.25161242
7MAP3K42.96140806
8MAP2K72.94425027
9DAPK22.77736252
10MARK12.66001206
11RIPK42.47978537
12WNK32.47889393
13BMPR1B2.40978735
14MAP3K122.35603403
15MINK12.33395862
16ACVR1B2.29590128
17MAP2K42.11421858
18PLK22.09658897
19TNIK2.02489863
20DAPK11.97681571
21GRK11.80146175
22STK38L1.78897565
23CDK191.78522000
24NTRK21.73835396
25PRPF4B1.71321746
26PNCK1.63362930
27IRAK31.61865977
28PAK61.59912901
29GRK51.58516114
30KSR21.54860665
31KSR11.51852570
32MAPK131.47823181
33LIMK11.47787236
34SIK21.43598933
35FES1.42922491
36MAP3K131.42699133
37CDK51.38167903
38LMTK21.32790911
39CSNK1G31.27815814
40BMPR21.27475305
41NTRK11.26682941
42ARAF1.25225139
43CAMKK11.25192485
44CSNK1A1L1.24539652
45PTK2B1.23502868
46PRKCG1.22254617
47CAMK2A1.16290506
48CSNK1G11.15705262
49MAP4K21.15251770
50ERBB41.13493629
51INSRR1.06683713
52OXSR11.05877059
53PRKD31.04541102
54CCNB11.03931168
55ZAK1.01224893
56FGR1.01091880
57CAMK2B0.98723499
58WNK40.95085954
59MKNK20.94754489
60NME10.91808310
61MAP3K60.88733471
62MUSK0.88591020
63CAMK10.87594587
64DYRK1A0.85167628
65STK240.83601989
66EIF2AK30.83215142
67NEK90.82358475
68UHMK10.79454820
69MAP3K20.77917228
70AKT30.77882150
71RAF10.76433173
72CDK180.75427819
73CAMKK20.75341555
74STK380.74635145
75PRKD20.73382030
76SGK4940.72624422
77SGK2230.72624422
78CDK140.72072113
79TGFBR10.71822886
80CDK150.71523657
81CAMK1G0.69813924
82STK110.69276877
83MAPKAPK50.68463466
84SGK10.68361118
85PRKCE0.64378774
86SIK30.63497514
87FER0.62394037
88STK390.61898846
89CDK11A0.61191972
90SGK20.60744400
91TYRO30.60091428
92MAPKAPK30.59960288
93LATS20.58985697
94ABL20.56391566
95PHKG10.55551243
96PHKG20.55551243
97MAP2K60.55394669
98CAMK2D0.54609023
99TESK10.53060486
100MARK20.51456455
101PAK30.50903561
102MAPK110.50805974
103MAPK120.50736023
104BCKDK0.49909265
105CSNK1G20.49605081
106PDK10.49603660
107BRAF0.47633728
108PDPK10.47221145
109GRK60.46834255
110GRK70.46508957
111PRKCZ0.46084266
112ROCK10.45320095
113TRPM70.45107570
114DAPK30.44995668
115CDK30.43116173
116RET0.42313114
117EIF2AK10.41307395
118PINK10.40281219
119PRKCI0.40081684
120PRKG10.39715071
121CAMK2G0.37764973
122PRKCH0.37596050
123NEK60.37124560
124ERN10.36368920
125MAP3K70.36358860
126MOS0.35716956
127LATS10.35392459
128FYN0.34617980
129RPS6KA30.33784570
130ERBB30.32802684
131ROCK20.32463787
132GSK3A0.32419204
133MAP3K10.32049239
134BCR0.32003829
135SGK30.31755911
136MAP2K10.31666874
137PRKCA0.31541545
138FGFR20.31425913
139TNK20.31366251
140CSNK1A10.31134486
141MAPK100.30665407
142PKN10.30435723
143PTK20.30251172
144PRKCB0.30163442
145MAP3K30.30102889
146CAMK40.30089442
147ADRBK10.29165973
148DMPK0.28864890
149PRKACA0.28720900
150STK30.25778238
151ABL10.25141700
152CSNK1D0.23999785
153FLT30.23878238
154MET0.22433562
155PRKACB0.21214382
156PIM20.21100135
157CAMK1D0.20911161

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.39071948
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32305255
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.04584794
4Long-term potentiation_Homo sapiens_hsa047202.98364404
5Circadian entrainment_Homo sapiens_hsa047132.84245255
6Glutamatergic synapse_Homo sapiens_hsa047242.81416818
7GABAergic synapse_Homo sapiens_hsa047272.67727570
8Morphine addiction_Homo sapiens_hsa050322.66874943
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.66063960
10Amphetamine addiction_Homo sapiens_hsa050312.61216483
11Olfactory transduction_Homo sapiens_hsa047402.51012408
12Taste transduction_Homo sapiens_hsa047422.20860077
13Dopaminergic synapse_Homo sapiens_hsa047282.19789754
14Salivary secretion_Homo sapiens_hsa049702.17476890
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10462198
16Insulin secretion_Homo sapiens_hsa049112.00053465
17Lysosome_Homo sapiens_hsa041421.99513134
18Butanoate metabolism_Homo sapiens_hsa006501.97308627
19Collecting duct acid secretion_Homo sapiens_hsa049661.95114449
20Serotonergic synapse_Homo sapiens_hsa047261.92874411
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87627464
22Long-term depression_Homo sapiens_hsa047301.82294725
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82211003
24Cholinergic synapse_Homo sapiens_hsa047251.81199248
25Calcium signaling pathway_Homo sapiens_hsa040201.80856366
26Gastric acid secretion_Homo sapiens_hsa049711.80537199
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79008518
28Renin secretion_Homo sapiens_hsa049241.75368403
29Oxytocin signaling pathway_Homo sapiens_hsa049211.73012553
30Sphingolipid metabolism_Homo sapiens_hsa006001.69519203
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.66154103
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65527290
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50457627
34GnRH signaling pathway_Homo sapiens_hsa049121.45661020
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40108472
36Cocaine addiction_Homo sapiens_hsa050301.37135032
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36150042
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31750842
39cAMP signaling pathway_Homo sapiens_hsa040241.31668475
40Axon guidance_Homo sapiens_hsa043601.28305283
41Nitrogen metabolism_Homo sapiens_hsa009101.27558820
42Gap junction_Homo sapiens_hsa045401.22388649
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16287086
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12337881
45Vibrio cholerae infection_Homo sapiens_hsa051101.10139839
46Mineral absorption_Homo sapiens_hsa049781.09962678
47Estrogen signaling pathway_Homo sapiens_hsa049151.06715657
48ABC transporters_Homo sapiens_hsa020101.06520250
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03857473
50Type II diabetes mellitus_Homo sapiens_hsa049301.03828155
51Glioma_Homo sapiens_hsa052141.03422366
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03393762
53Melanogenesis_Homo sapiens_hsa049161.03066611
54Glycerolipid metabolism_Homo sapiens_hsa005611.02048745
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99877779
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99867801
57ErbB signaling pathway_Homo sapiens_hsa040120.99327288
58Cardiac muscle contraction_Homo sapiens_hsa042600.98676797
59Ether lipid metabolism_Homo sapiens_hsa005650.93782523
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.92484159
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90649211
62Phototransduction_Homo sapiens_hsa047440.88553910
63Pancreatic secretion_Homo sapiens_hsa049720.81322657
64Oocyte meiosis_Homo sapiens_hsa041140.79138535
65Dorso-ventral axis formation_Homo sapiens_hsa043200.78655167
66N-Glycan biosynthesis_Homo sapiens_hsa005100.77108967
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77105619
68Choline metabolism in cancer_Homo sapiens_hsa052310.76335096
69Selenocompound metabolism_Homo sapiens_hsa004500.74325603
70MAPK signaling pathway_Homo sapiens_hsa040100.74257395
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.73369907
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.70365004
73Alzheimers disease_Homo sapiens_hsa050100.69997585
74Tryptophan metabolism_Homo sapiens_hsa003800.69918169
75ECM-receptor interaction_Homo sapiens_hsa045120.69628233
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69397106
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65385616
78Linoleic acid metabolism_Homo sapiens_hsa005910.65367473
79Complement and coagulation cascades_Homo sapiens_hsa046100.64382619
80Ras signaling pathway_Homo sapiens_hsa040140.63121768
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62886234
82Circadian rhythm_Homo sapiens_hsa047100.62605036
83Dilated cardiomyopathy_Homo sapiens_hsa054140.61780326
84African trypanosomiasis_Homo sapiens_hsa051430.61641135
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61314074
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61001134
87Oxidative phosphorylation_Homo sapiens_hsa001900.60239750
88Hedgehog signaling pathway_Homo sapiens_hsa043400.60101384
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60001332
90VEGF signaling pathway_Homo sapiens_hsa043700.59757866
91Thyroid hormone synthesis_Homo sapiens_hsa049180.58918028
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58629571
93Other glycan degradation_Homo sapiens_hsa005110.58457776
94Basal transcription factors_Homo sapiens_hsa030220.58309985
95Vitamin B6 metabolism_Homo sapiens_hsa007500.55625662
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54989460
97Propanoate metabolism_Homo sapiens_hsa006400.53595499
98Arachidonic acid metabolism_Homo sapiens_hsa005900.52447208
99Rap1 signaling pathway_Homo sapiens_hsa040150.51496380
100Glucagon signaling pathway_Homo sapiens_hsa049220.51403091
101Glutathione metabolism_Homo sapiens_hsa004800.50770191
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48520443
103Wnt signaling pathway_Homo sapiens_hsa043100.48319952
104Rheumatoid arthritis_Homo sapiens_hsa053230.48052446
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.47943842
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.47814737
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.46814606
108Type I diabetes mellitus_Homo sapiens_hsa049400.45426098
109Steroid biosynthesis_Homo sapiens_hsa001000.45353497
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45182926
111Inositol phosphate metabolism_Homo sapiens_hsa005620.41292915
112Metabolic pathways_Homo sapiens_hsa011000.39691922
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.38720518
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37917519
115Prion diseases_Homo sapiens_hsa050200.37831942
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37803228
117Peroxisome_Homo sapiens_hsa041460.36473375
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36418825
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35340850
120Ovarian steroidogenesis_Homo sapiens_hsa049130.33559923
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33355837
122Alcoholism_Homo sapiens_hsa050340.33038126
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32025341
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30979588
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.30713721
126Protein digestion and absorption_Homo sapiens_hsa049740.30338518
127Phagosome_Homo sapiens_hsa041450.29919709
128beta-Alanine metabolism_Homo sapiens_hsa004100.29196331
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29078804
130Hippo signaling pathway_Homo sapiens_hsa043900.27153130
131Renal cell carcinoma_Homo sapiens_hsa052110.27001599
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26944779
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26671668
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25823319
135Chemokine signaling pathway_Homo sapiens_hsa040620.25537359
136Focal adhesion_Homo sapiens_hsa045100.24199018
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23265853
138Bile secretion_Homo sapiens_hsa049760.22799660
139Endometrial cancer_Homo sapiens_hsa052130.22555349
140Endocytosis_Homo sapiens_hsa041440.22261686
141Non-small cell lung cancer_Homo sapiens_hsa052230.21974952
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20844722
143Parkinsons disease_Homo sapiens_hsa050120.20815337

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