CNIH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.97865157
2ribosomal large subunit biogenesis (GO:0042273)5.51642063
3ribosomal small subunit biogenesis (GO:0042274)5.44542476
4chaperone-mediated protein transport (GO:0072321)5.42435746
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.36609602
6viral transcription (GO:0019083)5.30037484
7translational termination (GO:0006415)5.23012073
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.09749050
9respiratory electron transport chain (GO:0022904)4.76706486
10maturation of SSU-rRNA (GO:0030490)4.72591469
11proteasome assembly (GO:0043248)4.71917760
12electron transport chain (GO:0022900)4.66066304
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53650272
14cotranslational protein targeting to membrane (GO:0006613)4.45289291
15translational elongation (GO:0006414)4.44648903
16protein targeting to ER (GO:0045047)4.42521192
17protein complex biogenesis (GO:0070271)4.26040717
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.20731535
19protein localization to endoplasmic reticulum (GO:0070972)4.19892453
20mitochondrial respiratory chain complex assembly (GO:0033108)4.18623255
21DNA deamination (GO:0045006)4.17629219
22translational initiation (GO:0006413)4.10743643
23cellular protein complex disassembly (GO:0043624)4.07433572
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.03328524
25NADH dehydrogenase complex assembly (GO:0010257)4.03328524
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03328524
27establishment of integrated proviral latency (GO:0075713)4.02405774
28viral life cycle (GO:0019058)4.00989785
29ribonucleoprotein complex biogenesis (GO:0022613)4.00758926
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.92149528
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90096517
32translation (GO:0006412)3.72787047
33respiratory chain complex IV assembly (GO:0008535)3.71752017
34protein targeting to mitochondrion (GO:0006626)3.66396273
35rRNA modification (GO:0000154)3.66229724
36telomere maintenance via semi-conservative replication (GO:0032201)3.65737989
37termination of RNA polymerase III transcription (GO:0006386)3.65255926
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.65255926
39histone exchange (GO:0043486)3.62685201
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.59341349
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57165215
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56657421
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.54813239
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53114356
45CENP-A containing nucleosome assembly (GO:0034080)3.51880888
46negative regulation of ligase activity (GO:0051352)3.49991927
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49991927
48DNA strand elongation involved in DNA replication (GO:0006271)3.44818394
49cytochrome complex assembly (GO:0017004)3.43224424
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40455412
51protein complex disassembly (GO:0043241)3.40252492
52establishment of protein localization to mitochondrion (GO:0072655)3.37998949
53protein localization to mitochondrion (GO:0070585)3.37807536
54protein localization to kinetochore (GO:0034501)3.36000702
55telomere maintenance via recombination (GO:0000722)3.35194186
56chromatin remodeling at centromere (GO:0031055)3.33584199
57rRNA processing (GO:0006364)3.32413163
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32086097
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32086097
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31853733
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31853733
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31853733
63ATP synthesis coupled proton transport (GO:0015986)3.29366843
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29366843
65DNA strand elongation (GO:0022616)3.28812958
66inner mitochondrial membrane organization (GO:0007007)3.28742337
67cellular component biogenesis (GO:0044085)3.27636778
68regulation of mitotic spindle checkpoint (GO:1903504)3.25881196
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25881196
70macromolecular complex disassembly (GO:0032984)3.24925716
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24633919
72rRNA metabolic process (GO:0016072)3.23609233
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.21530511
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21530511
75DNA damage response, detection of DNA damage (GO:0042769)3.20506730
76pseudouridine synthesis (GO:0001522)3.20181015
77kinetochore organization (GO:0051383)3.19512200
78regulation of cellular amino acid metabolic process (GO:0006521)3.19154789
79mitotic metaphase plate congression (GO:0007080)3.19138523
80cullin deneddylation (GO:0010388)3.19062688
81establishment of viral latency (GO:0019043)3.18441160
82ATP biosynthetic process (GO:0006754)3.18277943
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.16620907
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14914000
85spindle checkpoint (GO:0031577)3.10484118
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09787778
87purine nucleobase biosynthetic process (GO:0009113)3.07698389
88mitotic recombination (GO:0006312)3.07311038
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06675255
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06675255
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06675255
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.06675255
93negative regulation of sister chromatid segregation (GO:0033046)3.06675255
94regulation of ligase activity (GO:0051340)3.06282399
95kinetochore assembly (GO:0051382)3.06114442
96purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04366448
97rRNA methylation (GO:0031167)3.02920548
98hydrogen ion transmembrane transport (GO:1902600)3.02359856
99positive regulation of ligase activity (GO:0051351)3.02309271
100purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01205489
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01180198
102oxidative phosphorylation (GO:0006119)3.00779985
103nuclear-transcribed mRNA catabolic process (GO:0000956)3.00298669
104negative regulation of chromosome segregation (GO:0051985)3.00140412
105formation of translation preinitiation complex (GO:0001731)2.98397828
106cell cycle G1/S phase transition (GO:0044843)2.94292572
107G1/S transition of mitotic cell cycle (GO:0000082)2.94292572
108ribosome biogenesis (GO:0042254)2.91041823
109DNA replication checkpoint (GO:0000076)2.90925475
110protein targeting to membrane (GO:0006612)2.89221045
111mRNA catabolic process (GO:0006402)2.86698756
112regulation of mitochondrial translation (GO:0070129)2.86291621
113telomere maintenance via telomere lengthening (GO:0010833)2.86213029
114ribosome assembly (GO:0042255)2.85023039
115termination of RNA polymerase I transcription (GO:0006363)2.84290057
116nucleobase-containing small molecule interconversion (GO:0015949)2.83938268
117respiratory burst (GO:0045730)2.83443088
118DNA replication initiation (GO:0006270)2.79391658
119positive regulation of cell cycle arrest (GO:0071158)2.79291789
120spliceosomal snRNP assembly (GO:0000387)2.78372728
121attachment of spindle microtubules to kinetochore (GO:0008608)2.77503350
122metaphase plate congression (GO:0051310)2.77367373
123protein neddylation (GO:0045116)2.77114551
124meiotic chromosome segregation (GO:0045132)2.75451584
1257-methylguanosine mRNA capping (GO:0006370)2.74859424
126antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.74597900
127transcription-coupled nucleotide-excision repair (GO:0006283)2.73944145
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73884668
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72648527
130GTP biosynthetic process (GO:0006183)2.72170567
131RNA capping (GO:0036260)2.72146422
1327-methylguanosine RNA capping (GO:0009452)2.72146422
133establishment of chromosome localization (GO:0051303)2.70867297
134DNA replication-independent nucleosome assembly (GO:0006336)2.69465080
135DNA replication-independent nucleosome organization (GO:0034724)2.69465080
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.69337976
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.69285578
138DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.67845158
139RNA catabolic process (GO:0006401)2.67533758
140spliceosomal complex assembly (GO:0000245)2.65923057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.36074838
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.29604109
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03109729
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.56957399
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43443871
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.43049527
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.32369763
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27601959
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20395635
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.05030133
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91477265
12* FOXM1_23109430_ChIP-Seq_U2OS_Human2.86368933
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81689387
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79938374
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77285250
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66891545
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61773188
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44476650
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40807696
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40313142
21DCP1A_22483619_ChIP-Seq_HELA_Human2.40185999
22VDR_23849224_ChIP-Seq_CD4+_Human2.39088503
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28603827
24ELK1_19687146_ChIP-ChIP_HELA_Human2.27934670
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24804491
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21304735
27XRN2_22483619_ChIP-Seq_HELA_Human2.20271354
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.19135972
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17604631
30IRF8_21731497_ChIP-ChIP_J774_Mouse2.15635289
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14232571
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02145244
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97912957
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.92229712
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.86318715
36TTF2_22483619_ChIP-Seq_HELA_Human1.84488846
37FOXP3_21729870_ChIP-Seq_TREG_Human1.80489788
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79251741
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78173064
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.72708727
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72318943
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70957533
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70759093
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63007327
45EWS_26573619_Chip-Seq_HEK293_Human1.61255411
46GABP_19822575_ChIP-Seq_HepG2_Human1.60322694
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59529543
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55332135
49* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54276457
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52693484
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50223852
52SPI1_23547873_ChIP-Seq_NB4_Human1.48481501
53AR_21909140_ChIP-Seq_LNCAP_Human1.47525293
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46386468
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.46100090
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44564256
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44512335
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44508373
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44025078
60FUS_26573619_Chip-Seq_HEK293_Human1.43616927
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.42863610
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.38164480
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.37587128
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36658132
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.36482974
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35874766
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.32338885
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31266010
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30061597
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29822551
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26635050
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25551645
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25394675
74VDR_22108803_ChIP-Seq_LS180_Human1.25293957
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.24548406
76* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24349797
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23090690
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21444611
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19827510
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18485807
81KDM5A_27292631_Chip-Seq_BREAST_Human1.17488279
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11755704
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09826935
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09416162
85* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09346563
86ZNF274_21170338_ChIP-Seq_K562_Hela1.08954623
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08195597
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03665967
89TFEB_21752829_ChIP-Seq_HELA_Human1.03611374
90MYC_18940864_ChIP-ChIP_HL60_Human1.02528330
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01928964
92* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01029230
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98824492
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98778598
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98438138
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96345764
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96109811
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96035208
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95376566
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.95110494
101* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94884309
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.91297627
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90830251
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90800641
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87538575
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87254388
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85656041
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.83704856
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.83683977
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81493195
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80267064
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80215084
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80205631
114P300_19829295_ChIP-Seq_ESCs_Human0.79497792
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79135297
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.78109450
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76331928
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76285354
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76010125
120IRF1_19129219_ChIP-ChIP_H3396_Human0.75964792
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75401227
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73756351
123ELF5_23300383_ChIP-Seq_T47D_Human0.72004490
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70215534
125TAF15_26573619_Chip-Seq_HEK293_Human0.68878551
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68545557
127* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67512644
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67230144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.44515588
2MP0009379_abnormal_foot_pigmentation3.17105528
3MP0004957_abnormal_blastocyst_morpholog2.92681881
4MP0006292_abnormal_olfactory_placode2.88722500
5MP0002938_white_spotting2.76829700
6MP0003806_abnormal_nucleotide_metabolis2.67731726
7MP0003111_abnormal_nucleus_morphology2.54879230
8MP0003077_abnormal_cell_cycle2.54187510
9MP0010094_abnormal_chromosome_stability2.47189524
10MP0002148_abnormal_hypersensitivity_rea2.41725575
11MP0003941_abnormal_skin_development2.32953418
12MP0008932_abnormal_embryonic_tissue2.31891451
13MP0001835_abnormal_antigen_presentation2.31816936
14MP0008007_abnormal_cellular_replicative2.19214792
15MP0010030_abnormal_orbit_morphology2.17714930
16MP0009785_altered_susceptibility_to2.04377186
17MP0008058_abnormal_DNA_repair2.02362673
18MP0003186_abnormal_redox_activity2.01439751
19MP0008057_abnormal_DNA_replication1.96251395
20MP0001853_heart_inflammation1.93248744
21MP0005408_hypopigmentation1.91887716
22MP0002102_abnormal_ear_morphology1.84255742
23MP0006072_abnormal_retinal_apoptosis1.81687427
24MP0001529_abnormal_vocalization1.78999129
25MP0003436_decreased_susceptibility_to1.75834259
26MP0003786_premature_aging1.75225401
27MP0000490_abnormal_crypts_of1.74933364
28MP0003136_yellow_coat_color1.73973401
29MP0010352_gastrointestinal_tract_polyps1.71185251
30MP0005000_abnormal_immune_tolerance1.60179851
31MP0003315_abnormal_perineum_morphology1.58382730
32MP0003937_abnormal_limbs/digits/tail_de1.56589264
33MP0009333_abnormal_splenocyte_physiolog1.53536479
34MP0003890_abnormal_embryonic-extraembry1.51301213
35MP0000858_altered_metastatic_potential1.51291366
36MP0005671_abnormal_response_to1.47422171
37MP0003724_increased_susceptibility_to1.47239029
38MP0005025_abnormal_response_to1.46927711
39MP0008789_abnormal_olfactory_epithelium1.46588046
40MP0003448_altered_tumor_morphology1.43551184
41MP0002419_abnormal_innate_immunity1.41628604
42MP0003011_delayed_dark_adaptation1.41381818
43MP0003718_maternal_effect1.38057108
44MP0001188_hyperpigmentation1.37847994
45MP0004133_heterotaxia1.34696802
46MP0002452_abnormal_antigen_presenting1.33838488
47MP0000372_irregular_coat_pigmentation1.32481673
48MP0002396_abnormal_hematopoietic_system1.31148550
49MP0002697_abnormal_eye_size1.27006078
50MP0001286_abnormal_eye_development1.24949012
51MP0001485_abnormal_pinna_reflex1.24404296
52MP0004808_abnormal_hematopoietic_stem1.23014658
53MP0000750_abnormal_muscle_regeneration1.22196597
54MP0002233_abnormal_nose_morphology1.21315198
55MP0000343_altered_response_to1.20641052
56MP0003567_abnormal_fetal_cardiomyocyte1.19727435
57MP0002006_tumorigenesis1.19200771
58MP0008877_abnormal_DNA_methylation1.18833587
59MP0002837_dystrophic_cardiac_calcinosis1.16373607
60MP0002877_abnormal_melanocyte_morpholog1.15571025
61MP0002160_abnormal_reproductive_system1.15088599
62MP0002234_abnormal_pharynx_morphology1.14642749
63MP0005253_abnormal_eye_physiology1.13750753
64MP0000647_abnormal_sebaceous_gland1.12926404
65MP0005171_absent_coat_pigmentation1.12755017
66MP0000350_abnormal_cell_proliferation1.12594423
67MP0003195_calcinosis1.11431287
68MP0001819_abnormal_immune_cell1.11051154
69MP0002723_abnormal_immune_serum1.10857435
70MP0005075_abnormal_melanosome_morpholog1.10640303
71MP0002420_abnormal_adaptive_immunity1.09990414
72MP0002090_abnormal_vision1.09113067
73MP0002638_abnormal_pupillary_reflex1.08580402
74MP0000566_synostosis1.08141872
75MP0003828_pulmonary_edema1.07649616
76MP0000685_abnormal_immune_system1.07416207
77MP0002653_abnormal_ependyma_morphology1.07399064
78MP0001764_abnormal_homeostasis1.06942969
79MP0002009_preneoplasia1.06329354
80MP0001879_abnormal_lymphatic_vessel1.06076117
81MP0002405_respiratory_system_inflammati1.05083422
82MP0002736_abnormal_nociception_after1.04863145
83MP0001533_abnormal_skeleton_physiology1.04473317
84MP0002085_abnormal_embryonic_tissue1.04149490
85MP0002210_abnormal_sex_determination1.03177867
86MP0001545_abnormal_hematopoietic_system1.02640314
87MP0005397_hematopoietic_system_phenotyp1.02640314
88MP0003119_abnormal_digestive_system1.01721155
89MP0001800_abnormal_humoral_immune1.01711231
90MP0002751_abnormal_autonomic_nervous1.01519460
91MP0004147_increased_porphyrin_level1.01493669
92MP0001697_abnormal_embryo_size1.01309184
93MP0000313_abnormal_cell_death1.00920426
94MP0002111_abnormal_tail_morphology1.00277016
95MP0002277_abnormal_respiratory_mucosa0.98087998
96MP0001324_abnormal_eye_pigmentation0.97888271
97MP0003755_abnormal_palate_morphology0.97601203
98MP0005389_reproductive_system_phenotype0.97583938
99MP0002282_abnormal_trachea_morphology0.95701554
100MP0006082_CNS_inflammation0.95559702
101MP0002254_reproductive_system_inflammat0.95513536
102MP0002084_abnormal_developmental_patter0.93682600
103MP0003950_abnormal_plasma_membrane0.93290059
104MP0002060_abnormal_skin_morphology0.93256698
105MP0005409_darkened_coat_color0.93172733
106MP0008004_abnormal_stomach_pH0.92737710
107MP0002019_abnormal_tumor_incidence0.92705393
108MP0010155_abnormal_intestine_physiology0.92660176
109MP0001145_abnormal_male_reproductive0.90203429
110MP0005391_vision/eye_phenotype0.90008999
111MP0005551_abnormal_eye_electrophysiolog0.89835797
112MP0002398_abnormal_bone_marrow0.89785067
113MP0000631_abnormal_neuroendocrine_gland0.89385660
114MP0008438_abnormal_cutaneous_collagen0.89167317
115MP0002722_abnormal_immune_system0.89071171
116MP0001542_abnormal_bone_strength0.88495419
117MP0002095_abnormal_skin_pigmentation0.88476050
118MP0000653_abnormal_sex_gland0.87947194
119MP0004947_skin_inflammation0.87885790
120MP0003123_paternal_imprinting0.87510553
121MP0000749_muscle_degeneration0.87354910
122MP0000716_abnormal_immune_system0.87334367
123MP0000689_abnormal_spleen_morphology0.87008933
124MP0001984_abnormal_olfaction0.86889216
125MP0003453_abnormal_keratinocyte_physiol0.86646474
126MP0005390_skeleton_phenotype0.86479185
127MP0003121_genomic_imprinting0.86329947
128MP0001730_embryonic_growth_arrest0.86066194
129MP0001929_abnormal_gametogenesis0.85901306
130MP0006035_abnormal_mitochondrial_morpho0.84442841
131MP0008995_early_reproductive_senescence0.84363836
132MP0002132_abnormal_respiratory_system0.83732045
133MP0002429_abnormal_blood_cell0.83494765
134MP0000358_abnormal_cell_content/0.82992486
135MP0000465_gastrointestinal_hemorrhage0.82704352
136MP0003938_abnormal_ear_development0.81772074
137MP0001919_abnormal_reproductive_system0.81689962
138MP0005023_abnormal_wound_healing0.81071685
139MP0004142_abnormal_muscle_tone0.80425690
140MP0005380_embryogenesis_phenotype0.78880646
141MP0001672_abnormal_embryogenesis/_devel0.78880646
142MP0004381_abnormal_hair_follicle0.78630352
143MP0000049_abnormal_middle_ear0.77969374
144MP0009250_abnormal_appendicular_skeleto0.76693411
145MP0001299_abnormal_eye_distance/0.76039072
146MP0005394_taste/olfaction_phenotype0.74643282
147MP0005499_abnormal_olfactory_system0.74643282
148MP0001845_abnormal_inflammatory_respons0.74414153
149MP0001346_abnormal_lacrimal_gland0.73156319
150MP0009697_abnormal_copulation0.72335002
151MP0005501_abnormal_skin_physiology0.72287318
152MP0001790_abnormal_immune_system0.72203201
153MP0005387_immune_system_phenotype0.72203201
154MP0005395_other_phenotype0.72062387
155MP0001293_anophthalmia0.71788527
156MP0001216_abnormal_epidermal_layer0.71496039
157MP0005174_abnormal_tail_pigmentation0.70987304
158MP0000627_abnormal_mammary_gland0.70985952
159MP0006036_abnormal_mitochondrial_physio0.70273299
160MP0005195_abnormal_posterior_eye0.69802116
161MP0004782_abnormal_surfactant_physiolog0.69330986
162MP0002177_abnormal_outer_ear0.69320145
163MP0005187_abnormal_penis_morphology0.69069291
164MP0002080_prenatal_lethality0.68752809
165MP0005084_abnormal_gallbladder_morpholo0.68709326

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.98843286
2Microvesicular hepatic steatosis (HP:0001414)4.95187914
3Abnormal number of erythroid precursors (HP:0012131)4.71500005
4Reticulocytopenia (HP:0001896)4.67257855
5Pallor (HP:0000980)3.66386471
6Macrocytic anemia (HP:0001972)3.60671025
7Cerebral edema (HP:0002181)3.57538258
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.40268377
9Poor head control (HP:0002421)3.39914082
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.11232760
11Recurrent abscess formation (HP:0002722)3.07724854
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.07410386
13Increased hepatocellular lipid droplets (HP:0006565)3.04749165
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02295604
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02295604
16Abnormal hemoglobin (HP:0011902)2.96609110
17Exertional dyspnea (HP:0002875)2.95294430
18Birth length less than 3rd percentile (HP:0003561)2.91183931
19Stenosis of the external auditory canal (HP:0000402)2.88755596
20Mitochondrial inheritance (HP:0001427)2.83864000
21Abnormality of methionine metabolism (HP:0010901)2.71304764
22Trismus (HP:0000211)2.68519698
23Exercise intolerance (HP:0003546)2.67834259
24Abnormality of placental membranes (HP:0011409)2.67609848
25Amniotic constriction ring (HP:0009775)2.67609848
263-Methylglutaconic aciduria (HP:0003535)2.67531248
27Rough bone trabeculation (HP:0100670)2.66881029
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.66756261
29Methylmalonic acidemia (HP:0002912)2.64875175
30Septo-optic dysplasia (HP:0100842)2.62661469
31Methylmalonic aciduria (HP:0012120)2.62185901
32Acute necrotizing encephalopathy (HP:0006965)2.59852833
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54823550
34Leukodystrophy (HP:0002415)2.53760041
35Breast hypoplasia (HP:0003187)2.52752583
36Hepatocellular necrosis (HP:0001404)2.51713171
37Abnormal lung lobation (HP:0002101)2.51455686
38Elevated erythrocyte sedimentation rate (HP:0003565)2.50734363
39Lipid accumulation in hepatocytes (HP:0006561)2.49123349
40Type 2 muscle fiber atrophy (HP:0003554)2.48030211
41Muscle fiber atrophy (HP:0100295)2.45061001
42Renal Fanconi syndrome (HP:0001994)2.43630192
43Increased CSF lactate (HP:0002490)2.39121147
44Abnormality of the ileum (HP:0001549)2.38266905
45Optic disc pallor (HP:0000543)2.37364138
46Abnormality of serum amino acid levels (HP:0003112)2.36473120
47Premature graying of hair (HP:0002216)2.33984934
48Abnormal mitochondria in muscle tissue (HP:0008316)2.30938684
49Recurrent bacterial skin infections (HP:0005406)2.29032615
50Thrombocytosis (HP:0001894)2.28518343
51Increased intramyocellular lipid droplets (HP:0012240)2.27740165
52Sparse eyelashes (HP:0000653)2.26455977
53Abnormality of the labia minora (HP:0012880)2.26451342
54Aplastic anemia (HP:0001915)2.26281646
55Abnormal protein glycosylation (HP:0012346)2.26256774
56Abnormal glycosylation (HP:0012345)2.26256774
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26256774
58Abnormal protein N-linked glycosylation (HP:0012347)2.26256774
59Pancreatic cysts (HP:0001737)2.25962048
60Increased serum lactate (HP:0002151)2.25516847
61Lethargy (HP:0001254)2.24230864
62Absent thumb (HP:0009777)2.24204068
63Myositis (HP:0100614)2.23461661
64Chronic obstructive pulmonary disease (HP:0006510)2.22597200
65Obstructive lung disease (HP:0006536)2.22597200
66Type I transferrin isoform profile (HP:0003642)2.21332752
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.21236485
68Reduced antithrombin III activity (HP:0001976)2.19891379
69Abnormality of the anterior horn cell (HP:0006802)2.19629875
70Degeneration of anterior horn cells (HP:0002398)2.19629875
71Abnormal trabecular bone morphology (HP:0100671)2.19262982
72Pancreatic fibrosis (HP:0100732)2.18510222
73Progressive muscle weakness (HP:0003323)2.18149512
74Congenital, generalized hypertrichosis (HP:0004540)2.17645116
75Hyperglycinemia (HP:0002154)2.17474781
76Conical tooth (HP:0000698)2.15859573
77Megaloblastic anemia (HP:0001889)2.15390543
78Nemaline bodies (HP:0003798)2.14961479
79Abnormality of chromosome stability (HP:0003220)2.12694980
80Parakeratosis (HP:0001036)2.12653395
81Hepatic necrosis (HP:0002605)2.08343219
82Molar tooth sign on MRI (HP:0002419)2.06438849
83Abnormality of midbrain morphology (HP:0002418)2.06438849
84Cleft eyelid (HP:0000625)2.05026298
85Chromsome breakage (HP:0040012)2.03653584
86Petechiae (HP:0000967)2.03581502
87Abnormality of urine glucose concentration (HP:0011016)2.03075642
88Glycosuria (HP:0003076)2.03075642
89Pancytopenia (HP:0001876)2.01736161
90Absent septum pellucidum (HP:0001331)2.01724310
91Cerebral hypomyelination (HP:0006808)2.01050303
92True hermaphroditism (HP:0010459)2.00352606
93Patchy hypopigmentation of hair (HP:0011365)1.99024947
94Retrobulbar optic neuritis (HP:0100654)1.97080284
95Optic neuritis (HP:0100653)1.97080284
96Progressive macrocephaly (HP:0004481)1.96025120
97Oral leukoplakia (HP:0002745)1.95687620
98Colon cancer (HP:0003003)1.94807535
99Respiratory difficulties (HP:0002880)1.94646520
100Abnormality of macrophages (HP:0004311)1.93187167
101Congenital ichthyosiform erythroderma (HP:0007431)1.92206805
102Abnormality of the preputium (HP:0100587)1.91469280
103Triphalangeal thumb (HP:0001199)1.89982628
10411 pairs of ribs (HP:0000878)1.89636450
105X-linked dominant inheritance (HP:0001423)1.89444930
106Abnormality of the umbilical cord (HP:0010881)1.89282687
107Medial flaring of the eyebrow (HP:0010747)1.87586313
108Duodenal stenosis (HP:0100867)1.86893364
109Small intestinal stenosis (HP:0012848)1.86893364
110Prolonged neonatal jaundice (HP:0006579)1.86852690
111Mediastinal lymphadenopathy (HP:0100721)1.86788481
112Orchitis (HP:0100796)1.86215016
113Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85575231
114Homocystinuria (HP:0002156)1.85521086
115Abnormality of homocysteine metabolism (HP:0010919)1.85521086
116Pendular nystagmus (HP:0012043)1.84415275
117Hyperphosphaturia (HP:0003109)1.83780094
118CNS demyelination (HP:0007305)1.82480924
119Abnormalities of placenta or umbilical cord (HP:0001194)1.82071186
120Aplasia/hypoplasia of the uterus (HP:0008684)1.81490734
121Acute encephalopathy (HP:0006846)1.80295358
122Abnormality of the septum pellucidum (HP:0007375)1.79890233
123Bilateral microphthalmos (HP:0007633)1.79773203
124Bone marrow hypocellularity (HP:0005528)1.77945437
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77011710
126Abnormality of alanine metabolism (HP:0010916)1.77011710
127Hyperalaninemia (HP:0003348)1.77011710
128Bifid tongue (HP:0010297)1.75684053
129Abnormality of the duodenum (HP:0002246)1.75590236
130Sclerocornea (HP:0000647)1.75512547
131Duplicated collecting system (HP:0000081)1.72834422
132Increased muscle lipid content (HP:0009058)1.72579950
133Respiratory failure (HP:0002878)1.72342372
134Pustule (HP:0200039)1.72102075
135Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71936585
136Lactic acidosis (HP:0003128)1.69901460
137Agnosia (HP:0010524)1.69788250
138Eczematoid dermatitis (HP:0000976)1.68429942
139Ridged nail (HP:0001807)1.67142416
140Meckel diverticulum (HP:0002245)1.66780767
141Multiple enchondromatosis (HP:0005701)1.66780283
142Abnormality of the renal collecting system (HP:0004742)1.66380797
143Horseshoe kidney (HP:0000085)1.66117461
144Depressed nasal ridge (HP:0000457)1.65100146
145Abnormality of glycolysis (HP:0004366)1.63406920
146Increased serum pyruvate (HP:0003542)1.63406920
147Abnormality of renal resorption (HP:0011038)1.62732693
148Absent radius (HP:0003974)1.62252950
149Microretrognathia (HP:0000308)1.60725187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.05686451
2BUB14.89719166
3VRK24.68277659
4PBK3.60540551
5NME23.24305228
6EIF2AK32.95950774
7WEE12.83336936
8STK162.23975201
9PIM22.15543719
10MST42.06872492
11PLK41.98873408
12TRIM281.98514060
13TAF11.97790660
14WNK31.79893240
15ZAK1.78003954
16MKNK11.77064412
17VRK11.73602221
18TLK11.70623359
19BRSK21.66771105
20RPS6KB21.59484220
21SRPK11.58909473
22BLK1.54915363
23IRAK41.53131081
24EIF2AK21.51282260
25IRAK31.43359820
26RPS6KA41.42046508
27ACVR1B1.38821472
28EPHA21.38423924
29LIMK11.33787044
30MKNK21.33176542
31TESK11.29173985
32MAP3K111.28677819
33BRSK11.28186168
34CDC71.25844771
35NEK91.24502456
36ILK1.24357573
37NME11.21750125
38TESK21.20155807
39DYRK21.19501827
40ABL21.18520914
41BCKDK1.17858221
42MAP3K141.15339070
43PLK11.12415055
44AURKB1.11013821
45CDK71.10742734
46PDK21.07035454
47CSNK1G11.06895687
48TTK1.02519653
49TSSK61.01018588
50IKBKB1.01009092
51KDR1.00605812
52STK41.00257654
53BMPR1B0.98065644
54CSNK1G30.96205282
55GRK10.93989523
56PAK40.91914515
57MAP3K120.91003825
58LRRK20.90208686
59STK30.88957519
60TBK10.86764943
61PLK20.85493111
62CDK80.84973199
63CSNK1G20.84280324
64ADRBK20.83510046
65MUSK0.81768032
66MAP4K20.81314360
67DYRK30.80708217
68TXK0.80405232
69AURKA0.80389259
70PIM10.80199117
71CSNK1A1L0.79835829
72PINK10.79214203
73STK240.77916913
74PAK10.75993451
75MYLK0.75521285
76PLK30.74484502
77CHEK20.73570102
78RIPK40.73078863
79MAP3K30.71345772
80MAP3K80.70716616
81NEK20.70695489
82OXSR10.67970461
83TEC0.65252023
84BCR0.64123609
85NEK60.64095984
86CCNB10.63902681
87ATR0.63764892
88FRK0.62852766
89YES10.62221984
90ARAF0.60664235
91CASK0.60637878
92TRPM70.60336749
93KIT0.60329241
94MAP2K70.59739836
95TGFBR10.59492565
96CSNK2A10.59024894
97TAOK20.58611419
98PNCK0.57731689
99STK100.57697280
100TYK20.56392425
101MAP4K10.55304641
102ATM0.52632474
103TIE10.51735450
104MELK0.51319952
105RPS6KA50.50922123
106MAP3K40.50771573
107NEK10.50588118
108MOS0.50563275
109CDK190.50518965
110INSRR0.49901980
111TNIK0.49597382
112MAP2K30.49507058
113LYN0.47271510
114PRKCG0.46908345
115FGFR10.46746539
116PASK0.46102387
117CHEK10.43560949
118EPHA40.43372127
119ERBB30.42428486
120ERBB40.41750807
121OBSCN0.41635353
122STK390.41428987
123BMPR20.38974644
124IKBKE0.37591647
125CDK30.37148684
126PRKCD0.36371116
127MAPKAPK30.36040249
128MARK30.35273380
129PRKG20.34568886
130CSNK1E0.34085227
131CSNK1A10.33745729
132ADRBK10.33369940
133FLT30.32703436
134STK38L0.32595466
135PRKCE0.32581047
136CSNK2A20.31434493
137MAPKAPK20.30633980
138EPHB20.30506812
139ROCK20.30199276
140BTK0.30085493
141NUAK10.29859554
142MINK10.28136015
143CDK10.27434816

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.20693860
2Proteasome_Homo sapiens_hsa030504.36894225
3DNA replication_Homo sapiens_hsa030303.52059409
4RNA polymerase_Homo sapiens_hsa030203.44664000
5Mismatch repair_Homo sapiens_hsa034303.01115266
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89258533
7Homologous recombination_Homo sapiens_hsa034402.66672888
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.45909581
9Pyrimidine metabolism_Homo sapiens_hsa002402.28695488
10Spliceosome_Homo sapiens_hsa030402.23744346
11Nucleotide excision repair_Homo sapiens_hsa034202.16696353
12Oxidative phosphorylation_Homo sapiens_hsa001902.14152810
13Parkinsons disease_Homo sapiens_hsa050121.99258413
14Base excision repair_Homo sapiens_hsa034101.95941951
15Fanconi anemia pathway_Homo sapiens_hsa034601.80005023
16RNA transport_Homo sapiens_hsa030131.76446081
17Cell cycle_Homo sapiens_hsa041101.72280397
18Protein export_Homo sapiens_hsa030601.61038193
19Huntingtons disease_Homo sapiens_hsa050161.53568341
20Propanoate metabolism_Homo sapiens_hsa006401.41172460
21RNA degradation_Homo sapiens_hsa030181.40979034
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37759117
23Basal transcription factors_Homo sapiens_hsa030221.35390616
24p53 signaling pathway_Homo sapiens_hsa041151.32688196
25Non-homologous end-joining_Homo sapiens_hsa034501.30326698
26Pyruvate metabolism_Homo sapiens_hsa006201.27486384
27Purine metabolism_Homo sapiens_hsa002301.21950298
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21128384
29Alzheimers disease_Homo sapiens_hsa050101.19885665
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19206785
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18995681
32Legionellosis_Homo sapiens_hsa051341.17467736
33Fatty acid elongation_Homo sapiens_hsa000621.17415981
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16412907
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16044298
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.15525588
37Graft-versus-host disease_Homo sapiens_hsa053321.15347415
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07225473
39Epstein-Barr virus infection_Homo sapiens_hsa051691.06194390
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02657968
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00992010
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96661285
43One carbon pool by folate_Homo sapiens_hsa006700.96494522
44Herpes simplex infection_Homo sapiens_hsa051680.96034458
45Leishmaniasis_Homo sapiens_hsa051400.95006070
46Selenocompound metabolism_Homo sapiens_hsa004500.93388183
47Steroid biosynthesis_Homo sapiens_hsa001000.91527175
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88674462
49Systemic lupus erythematosus_Homo sapiens_hsa053220.88537759
50Malaria_Homo sapiens_hsa051440.86413728
51Salmonella infection_Homo sapiens_hsa051320.83508252
52Allograft rejection_Homo sapiens_hsa053300.83054861
53Sulfur metabolism_Homo sapiens_hsa009200.82883673
54Shigellosis_Homo sapiens_hsa051310.81914059
55Arachidonic acid metabolism_Homo sapiens_hsa005900.80468282
56Vitamin digestion and absorption_Homo sapiens_hsa049770.79994965
57Rheumatoid arthritis_Homo sapiens_hsa053230.79307919
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.79170833
59Glutathione metabolism_Homo sapiens_hsa004800.75659844
60Pertussis_Homo sapiens_hsa051330.75604115
61Folate biosynthesis_Homo sapiens_hsa007900.75491431
62Apoptosis_Homo sapiens_hsa042100.75387687
63Measles_Homo sapiens_hsa051620.74942406
64Phagosome_Homo sapiens_hsa041450.74382564
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70794241
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.70747537
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70480612
68Asthma_Homo sapiens_hsa053100.70099197
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69366471
70Hematopoietic cell lineage_Homo sapiens_hsa046400.67810177
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66954627
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66140770
73Carbon metabolism_Homo sapiens_hsa012000.65280275
74Peroxisome_Homo sapiens_hsa041460.64219070
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64030114
76Sphingolipid metabolism_Homo sapiens_hsa006000.63072733
77Collecting duct acid secretion_Homo sapiens_hsa049660.62968344
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62698236
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62631542
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62614651
81Antigen processing and presentation_Homo sapiens_hsa046120.62480687
82Other glycan degradation_Homo sapiens_hsa005110.60549426
83Biosynthesis of amino acids_Homo sapiens_hsa012300.60440648
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59567171
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59176333
86Oocyte meiosis_Homo sapiens_hsa041140.57361596
87Tuberculosis_Homo sapiens_hsa051520.57166371
88N-Glycan biosynthesis_Homo sapiens_hsa005100.56245864
89Pentose phosphate pathway_Homo sapiens_hsa000300.55498665
90Phototransduction_Homo sapiens_hsa047440.53082052
91Influenza A_Homo sapiens_hsa051640.52980968
92Cardiac muscle contraction_Homo sapiens_hsa042600.52709944
93Chemical carcinogenesis_Homo sapiens_hsa052040.52540742
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52322546
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51234169
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.51026871
97HTLV-I infection_Homo sapiens_hsa051660.49988513
98Vitamin B6 metabolism_Homo sapiens_hsa007500.49395294
99Viral carcinogenesis_Homo sapiens_hsa052030.48650981
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48300402
101TNF signaling pathway_Homo sapiens_hsa046680.47328373
102Basal cell carcinoma_Homo sapiens_hsa052170.47258405
103Butanoate metabolism_Homo sapiens_hsa006500.45610889
104mRNA surveillance pathway_Homo sapiens_hsa030150.43830899
105Caffeine metabolism_Homo sapiens_hsa002320.43570616
106Nitrogen metabolism_Homo sapiens_hsa009100.43381377
107Sulfur relay system_Homo sapiens_hsa041220.42539902
108Autoimmune thyroid disease_Homo sapiens_hsa053200.42238627
109HIF-1 signaling pathway_Homo sapiens_hsa040660.41865286
110Retinol metabolism_Homo sapiens_hsa008300.41285839
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40217078
112Fatty acid degradation_Homo sapiens_hsa000710.40152152
113Tryptophan metabolism_Homo sapiens_hsa003800.39946765
114Arginine and proline metabolism_Homo sapiens_hsa003300.39767554
115beta-Alanine metabolism_Homo sapiens_hsa004100.39710109
116Small cell lung cancer_Homo sapiens_hsa052220.39285634
117Fructose and mannose metabolism_Homo sapiens_hsa000510.39258502
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.38806628
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37078746
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36599648
121Osteoclast differentiation_Homo sapiens_hsa043800.36350552
122Viral myocarditis_Homo sapiens_hsa054160.35496373
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35286764
124Hedgehog signaling pathway_Homo sapiens_hsa043400.34773285
125Lysosome_Homo sapiens_hsa041420.34718134
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34464913
127Hepatitis B_Homo sapiens_hsa051610.33135868
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.32904014
129Metabolic pathways_Homo sapiens_hsa011000.31310424
130Tyrosine metabolism_Homo sapiens_hsa003500.31260598
131Fatty acid metabolism_Homo sapiens_hsa012120.29297426
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.29247847
133MicroRNAs in cancer_Homo sapiens_hsa052060.28343876
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27909876
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27701690
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.25573175
137Mineral absorption_Homo sapiens_hsa049780.25550296
138Regulation of autophagy_Homo sapiens_hsa041400.23553558
139Galactose metabolism_Homo sapiens_hsa000520.22482533
140Hepatitis C_Homo sapiens_hsa051600.22439981
141Hippo signaling pathway_Homo sapiens_hsa043900.21913740
142Acute myeloid leukemia_Homo sapiens_hsa052210.20852706
143Vibrio cholerae infection_Homo sapiens_hsa051100.20636077
144Toxoplasmosis_Homo sapiens_hsa051450.20490521
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20460735
146Wnt signaling pathway_Homo sapiens_hsa043100.20344432
147TGF-beta signaling pathway_Homo sapiens_hsa043500.20215453
148Type I diabetes mellitus_Homo sapiens_hsa049400.19429502
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19210934
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19194220
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.18397704
152Linoleic acid metabolism_Homo sapiens_hsa005910.17153456
153Fat digestion and absorption_Homo sapiens_hsa049750.16883053
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15465016
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15376308
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14778860

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