CNKSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.69504783
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.65186446
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62469746
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.62266665
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.50136967
6locomotory exploration behavior (GO:0035641)5.34784749
7glutamate receptor signaling pathway (GO:0007215)5.22561000
8protein localization to synapse (GO:0035418)5.20242908
9synaptic vesicle exocytosis (GO:0016079)5.17096546
10regulation of glutamate receptor signaling pathway (GO:1900449)5.06376966
11glutamate secretion (GO:0014047)4.95397337
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91421231
13neuron cell-cell adhesion (GO:0007158)4.84947573
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.77726357
15synaptic vesicle maturation (GO:0016188)4.72982412
16synaptic transmission, glutamatergic (GO:0035249)4.72265034
17exploration behavior (GO:0035640)4.67604493
18neuronal action potential propagation (GO:0019227)4.61972817
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.56587939
20regulation of synaptic vesicle exocytosis (GO:2000300)4.56449386
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.56226839
22neuron-neuron synaptic transmission (GO:0007270)4.55696836
23regulation of neuronal synaptic plasticity (GO:0048168)4.46668749
24regulation of excitatory postsynaptic membrane potential (GO:0060079)4.34700444
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.24912044
26sodium ion export (GO:0071436)4.20856903
27regulation of synaptic vesicle transport (GO:1902803)4.19156500
28neuron recognition (GO:0008038)4.16973401
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.15797230
30positive regulation of synapse maturation (GO:0090129)4.13828122
31regulation of postsynaptic membrane potential (GO:0060078)4.11872336
32regulation of dendritic spine morphogenesis (GO:0061001)4.09646933
33long-term memory (GO:0007616)4.08983090
34neurotransmitter-gated ion channel clustering (GO:0072578)4.04825562
35dendritic spine morphogenesis (GO:0060997)4.01335469
36regulation of synaptic plasticity (GO:0048167)3.99706504
37long-term synaptic potentiation (GO:0060291)3.95220821
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.92451170
39behavioral fear response (GO:0001662)3.92249287
40behavioral defense response (GO:0002209)3.92249287
41L-amino acid import (GO:0043092)3.92234974
42regulation of synapse structural plasticity (GO:0051823)3.86167311
43neurotransmitter secretion (GO:0007269)3.85718472
44axonal fasciculation (GO:0007413)3.84933929
45positive regulation of membrane potential (GO:0045838)3.79492885
46G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.78850099
47positive regulation of neurotransmitter secretion (GO:0001956)3.75658627
48response to histamine (GO:0034776)3.75526209
49fear response (GO:0042596)3.74769612
50presynaptic membrane assembly (GO:0097105)3.70462059
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66699337
52synaptic vesicle endocytosis (GO:0048488)3.64009442
53transmission of nerve impulse (GO:0019226)3.61083861
54dendritic spine organization (GO:0097061)3.60984096
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.60783758
56axon ensheathment in central nervous system (GO:0032291)3.58019092
57central nervous system myelination (GO:0022010)3.58019092
58potassium ion homeostasis (GO:0055075)3.57658535
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57569325
60regulation of dendritic spine development (GO:0060998)3.56448604
61neuronal ion channel clustering (GO:0045161)3.54906551
62potassium ion import (GO:0010107)3.53666479
63cellular potassium ion homeostasis (GO:0030007)3.53132923
64long term synaptic depression (GO:0060292)3.50543991
65layer formation in cerebral cortex (GO:0021819)3.50144274
66C4-dicarboxylate transport (GO:0015740)3.50099496
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.47906395
68postsynaptic membrane organization (GO:0001941)3.46744953
69positive regulation of dendritic spine development (GO:0060999)3.41591260
70regulation of vesicle fusion (GO:0031338)3.40230103
71regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.39819676
72presynaptic membrane organization (GO:0097090)3.39337217
73chemosensory behavior (GO:0007635)3.39317946
74neurotransmitter uptake (GO:0001504)3.39276893
75regulation of voltage-gated calcium channel activity (GO:1901385)3.38319044
76innervation (GO:0060384)3.37318584
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36103146
78learning (GO:0007612)3.35473912
79membrane depolarization (GO:0051899)3.34843873
80regulation of glutamate secretion (GO:0014048)3.33715358
81cellular sodium ion homeostasis (GO:0006883)3.33467499
82behavioral response to cocaine (GO:0048148)3.32019093
83amino acid import (GO:0043090)3.30994115
84positive regulation of neurotransmitter transport (GO:0051590)3.30945402
85regulation of neurotransmitter secretion (GO:0046928)3.28894234
86cell differentiation in hindbrain (GO:0021533)3.24983501
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24843369
88positive regulation of potassium ion transmembrane transport (GO:1901381)3.22457148
89neurotransmitter transport (GO:0006836)3.21371645
90cell communication by electrical coupling (GO:0010644)3.21334454
91neuromuscular synaptic transmission (GO:0007274)3.20830164
92mechanosensory behavior (GO:0007638)3.20468718
93regulation of synapse maturation (GO:0090128)3.19001145
94gamma-aminobutyric acid transport (GO:0015812)3.18434504
95adult walking behavior (GO:0007628)3.18127515
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17435159
97cochlea development (GO:0090102)3.16319554
98detection of calcium ion (GO:0005513)3.12564690
99primary amino compound metabolic process (GO:1901160)3.12260137
100neuromuscular process controlling balance (GO:0050885)3.12072686
101proline transport (GO:0015824)3.11833256
102neuromuscular process controlling posture (GO:0050884)3.09314040
103regulation of female receptivity (GO:0045924)3.09170360
104acidic amino acid transport (GO:0015800)3.08983769
105regulation of synaptic transmission (GO:0050804)3.08453067
106response to auditory stimulus (GO:0010996)3.07701028
107startle response (GO:0001964)3.07431453
108cerebellar Purkinje cell differentiation (GO:0021702)3.04534297
109serotonin metabolic process (GO:0042428)3.03304224
110vesicle transport along microtubule (GO:0047496)3.02956887
111membrane depolarization during action potential (GO:0086010)3.02954679
112cerebellar granule cell differentiation (GO:0021707)3.02788207
113synaptic transmission (GO:0007268)3.02718679
114positive regulation of synaptic transmission (GO:0050806)3.01833089
115regulation of neurotransmitter transport (GO:0051588)3.00288056
116regulation of neurotransmitter levels (GO:0001505)2.98984859
117dendrite morphogenesis (GO:0048813)2.97879011
118auditory behavior (GO:0031223)2.95258279
119synapse assembly (GO:0007416)2.95178234
120negative regulation of amino acid transport (GO:0051956)2.94757559
121activation of protein kinase A activity (GO:0034199)2.94693032
122central nervous system projection neuron axonogenesis (GO:0021952)2.94596050
123intraspecies interaction between organisms (GO:0051703)2.94495646
124social behavior (GO:0035176)2.94495646
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.94331221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.62660857
2GBX2_23144817_ChIP-Seq_PC3_Human4.14189807
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21388917
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20481893
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08361834
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74576408
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70658257
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70658257
9REST_21632747_ChIP-Seq_MESCs_Mouse2.64346892
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62053848
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.55311668
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55204495
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.49064257
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48659343
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45339759
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38473661
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.29845338
18DROSHA_22980978_ChIP-Seq_HELA_Human2.24698295
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.17479708
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12179764
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.11263309
22TAF15_26573619_Chip-Seq_HEK293_Human2.06573378
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04349085
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04073727
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.02221595
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00221015
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99961053
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85734184
29SMAD4_21799915_ChIP-Seq_A2780_Human1.84155383
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82585774
31AR_21572438_ChIP-Seq_LNCaP_Human1.82242153
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70567764
33* P300_19829295_ChIP-Seq_ESCs_Human1.66965657
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65968383
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65133428
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64871574
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61439562
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60099742
39ZNF274_21170338_ChIP-Seq_K562_Hela1.55881995
40FUS_26573619_Chip-Seq_HEK293_Human1.50582442
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.49320562
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45687556
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45167942
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44486273
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43585822
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43067981
47* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41157778
48AR_25329375_ChIP-Seq_VCAP_Human1.39535286
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39130541
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37385704
51TP53_16413492_ChIP-PET_HCT116_Human1.37096697
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36308219
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.35963136
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.35879867
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.33986371
56VDR_22108803_ChIP-Seq_LS180_Human1.33073858
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32968653
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32850020
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.31125412
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31040660
61IGF1R_20145208_ChIP-Seq_DFB_Human1.29590377
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28912914
63* STAT3_23295773_ChIP-Seq_U87_Human1.28304520
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23487045
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.21430904
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19842994
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19224523
68AR_19668381_ChIP-Seq_PC3_Human1.19024827
69TCF4_23295773_ChIP-Seq_U87_Human1.17004560
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.16613429
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16377750
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14701252
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.14468806
74* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14127098
75TP53_18474530_ChIP-ChIP_U2OS_Human1.13212150
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.11183463
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10976134
78RNF2_27304074_Chip-Seq_NSC_Mouse1.09458991
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08665517
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08403862
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07002538
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06721523
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.06531192
84SOX9_26525672_Chip-Seq_HEART_Mouse1.06458089
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05819632
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.05571295
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05501771
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05133248
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04529704
90KDM2B_26808549_Chip-Seq_REH_Human1.04117005
91* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03838173
92AHR_22903824_ChIP-Seq_MCF-7_Human1.03414429
93BCAT_22108803_ChIP-Seq_LS180_Human1.02864516
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02819938
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.01864587
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01762821
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01422875
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01422875
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00713656
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00712745
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00404876
102CBP_20019798_ChIP-Seq_JUKART_Human1.00404876
103* JUN_21703547_ChIP-Seq_K562_Human0.99772438
104* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99652100
105FLI1_21867929_ChIP-Seq_TH2_Mouse0.99354922
106EWS_26573619_Chip-Seq_HEK293_Human0.98246883
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.96971466
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96924221
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96250213
110RXR_22108803_ChIP-Seq_LS180_Human0.95413286
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94088888
112ER_23166858_ChIP-Seq_MCF-7_Human0.93124266
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92627117
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91096453
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.89103244
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.88709524
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87746541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.05647928
2MP0003880_abnormal_central_pattern5.76071087
3MP0003635_abnormal_synaptic_transmissio4.34384033
4MP0004270_analgesia3.92423726
5MP0009745_abnormal_behavioral_response3.66358829
6MP0002063_abnormal_learning/memory/cond3.61239595
7MP0002064_seizures3.18522149
8MP0001968_abnormal_touch/_nociception3.16011671
9MP0002572_abnormal_emotion/affect_behav2.99765039
10MP0009046_muscle_twitch2.77804486
11MP0002822_catalepsy2.67892667
12MP0002272_abnormal_nervous_system2.64827035
13MP0002736_abnormal_nociception_after2.61237429
14MP0001501_abnormal_sleep_pattern2.60662675
15MP0001486_abnormal_startle_reflex2.45936257
16MP0001440_abnormal_grooming_behavior2.40169273
17MP0002734_abnormal_mechanical_nocicepti2.39341426
18MP0002735_abnormal_chemical_nociception2.37464160
19MP0005423_abnormal_somatic_nervous2.15054533
20MP0003329_amyloid_beta_deposits1.99760723
21MP0002067_abnormal_sensory_capabilities1.97021350
22MP0000778_abnormal_nervous_system1.89093180
23MP0002733_abnormal_thermal_nociception1.88539112
24MP0001970_abnormal_pain_threshold1.80911366
25MP0002184_abnormal_innervation1.80907527
26MP0009780_abnormal_chondrocyte_physiolo1.76716639
27MP0004924_abnormal_behavior1.73673250
28MP0005386_behavior/neurological_phenoty1.73673250
29MP0008877_abnormal_DNA_methylation1.70040391
30MP0006276_abnormal_autonomic_nervous1.69593929
31MP0002557_abnormal_social/conspecific_i1.69448694
32MP0001529_abnormal_vocalization1.64282173
33MP0008569_lethality_at_weaning1.62876270
34MP0003879_abnormal_hair_cell1.62687141
35MP0004811_abnormal_neuron_physiology1.61388315
36MP0001188_hyperpigmentation1.60573042
37MP0002909_abnormal_adrenal_gland1.57828936
38MP0003787_abnormal_imprinting1.43991567
39MP0004858_abnormal_nervous_system1.43121899
40MP0005646_abnormal_pituitary_gland1.42936737
41MP0000955_abnormal_spinal_cord1.39717742
42MP0001905_abnormal_dopamine_level1.39548619
43MP0002066_abnormal_motor_capabilities/c1.37932958
44MP0001984_abnormal_olfaction1.36199915
45MP0003123_paternal_imprinting1.35107648
46MP0002882_abnormal_neuron_morphology1.33586615
47MP0004145_abnormal_muscle_electrophysio1.33435149
48MP0003633_abnormal_nervous_system1.31309586
49MP0002837_dystrophic_cardiac_calcinosis1.27431592
50MP0005409_darkened_coat_color1.18474285
51MP0001502_abnormal_circadian_rhythm1.15897108
52MP0003121_genomic_imprinting1.15525482
53MP0003631_nervous_system_phenotype1.13969900
54MP0004885_abnormal_endolymph1.10624955
55MP0002152_abnormal_brain_morphology1.08378523
56MP0005645_abnormal_hypothalamus_physiol1.06708803
57MP0008872_abnormal_physiological_respon1.01852272
58MP0010386_abnormal_urinary_bladder1.00217056
59MP0008874_decreased_physiological_sensi0.96654189
60MP0004484_altered_response_of0.96136693
61MP0004147_increased_porphyrin_level0.95521228
62MP0004510_myositis0.93939615
63MP0004142_abnormal_muscle_tone0.92302740
64MP0002069_abnormal_eating/drinking_beha0.92277059
65MP0000751_myopathy0.91662983
66MP0001986_abnormal_taste_sensitivity0.91183957
67MP0000604_amyloidosis0.90803282
68MP0003122_maternal_imprinting0.88508253
69MP0004742_abnormal_vestibular_system0.87778827
70MP0004085_abnormal_heartbeat0.86748835
71MP0005535_abnormal_body_temperature0.85801839
72MP0002638_abnormal_pupillary_reflex0.85616731
73MP0002876_abnormal_thyroid_physiology0.84336748
74MP0001963_abnormal_hearing_physiology0.84168540
75MP0002229_neurodegeneration0.83100168
76MP0005551_abnormal_eye_electrophysiolog0.81756228
77MP0004215_abnormal_myocardial_fiber0.78961195
78MP0003283_abnormal_digestive_organ0.77755998
79MP0003632_abnormal_nervous_system0.77752312
80MP0003075_altered_response_to0.76812530
81MP0003938_abnormal_ear_development0.76739996
82MP0006292_abnormal_olfactory_placode0.74176394
83MP0001664_abnormal_digestion0.71047125
84MP0001177_atelectasis0.70613894
85MP0004130_abnormal_muscle_cell0.70050999
86MP0001485_abnormal_pinna_reflex0.69850044
87MP0005394_taste/olfaction_phenotype0.69320954
88MP0005499_abnormal_olfactory_system0.69320954
89MP0000569_abnormal_digit_pigmentation0.68102853
90MP0002752_abnormal_somatic_nervous0.68092268
91MP0000631_abnormal_neuroendocrine_gland0.67657623
92MP0004133_heterotaxia0.66860970
93MP0005187_abnormal_penis_morphology0.66492806
94MP0000013_abnormal_adipose_tissue0.64312512
95MP0002160_abnormal_reproductive_system0.63974367
96MP0006072_abnormal_retinal_apoptosis0.62739723
97MP0001299_abnormal_eye_distance/0.62117788
98MP0000049_abnormal_middle_ear0.62049043
99MP0010234_abnormal_vibrissa_follicle0.61725710
100MP0002102_abnormal_ear_morphology0.60945781
101MP0002234_abnormal_pharynx_morphology0.59694900
102MP0003634_abnormal_glial_cell0.58600978
103MP0000920_abnormal_myelination0.58457874
104MP0002082_postnatal_lethality0.57778062
105MP0005253_abnormal_eye_physiology0.57774045
106MP0004233_abnormal_muscle_weight0.57691543
107MP0003119_abnormal_digestive_system0.55978559
108MP0003861_abnormal_nervous_system0.55889294
109MP0010768_mortality/aging0.55831591
110MP0001765_abnormal_ion_homeostasis0.55419905
111MP0005171_absent_coat_pigmentation0.55273007
112MP0000026_abnormal_inner_ear0.53915205
113MP0003137_abnormal_impulse_conducting0.50982290
114MP0001943_abnormal_respiration0.50068259
115MP0008961_abnormal_basal_metabolism0.49114959
116MP0003690_abnormal_glial_cell0.48515143
117MP0010769_abnormal_survival0.48463122
118MP0003956_abnormal_body_size0.47063416
119MP0010770_preweaning_lethality0.46906993

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.20803375
2Myokymia (HP:0002411)6.50276042
3Focal seizures (HP:0007359)6.38444176
4Epileptic encephalopathy (HP:0200134)5.61110427
5Visual hallucinations (HP:0002367)5.34662364
6Atonic seizures (HP:0010819)5.10925356
7Hyperventilation (HP:0002883)5.07053857
8Febrile seizures (HP:0002373)4.77370886
9Absence seizures (HP:0002121)4.74891646
10Dialeptic seizures (HP:0011146)4.44631235
11Broad-based gait (HP:0002136)4.32921475
12Progressive cerebellar ataxia (HP:0002073)4.30253792
13Generalized tonic-clonic seizures (HP:0002069)4.16738217
14Amblyopia (HP:0000646)3.80584520
15Poor eye contact (HP:0000817)3.69322520
16Gaze-evoked nystagmus (HP:0000640)3.58622540
17Action tremor (HP:0002345)3.57131954
18Cerebral inclusion bodies (HP:0100314)3.46355251
19Drooling (HP:0002307)3.36565883
20Excessive salivation (HP:0003781)3.36565883
21Dysmetria (HP:0001310)3.32011623
22Supranuclear gaze palsy (HP:0000605)3.27451501
23Impaired vibration sensation in the lower limbs (HP:0002166)3.26405261
24Dysdiadochokinesis (HP:0002075)3.25448332
25Limb dystonia (HP:0002451)3.22916427
26Impaired social interactions (HP:0000735)3.22739681
27Abnormal social behavior (HP:0012433)3.22739681
28Truncal ataxia (HP:0002078)3.19823194
29Absent speech (HP:0001344)3.07066885
30Anxiety (HP:0000739)3.03520180
31Impaired smooth pursuit (HP:0007772)2.97810218
32Neurofibrillary tangles (HP:0002185)2.95904363
33Epileptiform EEG discharges (HP:0011182)2.94015610
34Depression (HP:0000716)2.91709176
35Urinary bladder sphincter dysfunction (HP:0002839)2.77887203
36Hemiparesis (HP:0001269)2.74042107
37Scanning speech (HP:0002168)2.72776283
38Stereotypic behavior (HP:0000733)2.70289029
39Abnormality of binocular vision (HP:0011514)2.69691051
40Diplopia (HP:0000651)2.69691051
41Cerebral hypomyelination (HP:0006808)2.67814200
42Genetic anticipation (HP:0003743)2.64591629
43Protruding tongue (HP:0010808)2.62562088
44Termporal pattern (HP:0011008)2.59532991
45Insidious onset (HP:0003587)2.59532991
46EEG with generalized epileptiform discharges (HP:0011198)2.57930629
47Inability to walk (HP:0002540)2.51953225
48Abnormal eating behavior (HP:0100738)2.49187876
49Postural instability (HP:0002172)2.48036790
50Abnormality of ocular smooth pursuit (HP:0000617)2.44162455
51Abnormality of the lower motor neuron (HP:0002366)2.41765278
52Progressive inability to walk (HP:0002505)2.36989993
53Urinary urgency (HP:0000012)2.35591421
54Status epilepticus (HP:0002133)2.35014209
55Mutism (HP:0002300)2.34992614
56Delusions (HP:0000746)2.33631657
57Hypsarrhythmia (HP:0002521)2.32744712
58Abnormality of salivation (HP:0100755)2.31972156
59Sleep apnea (HP:0010535)2.31840095
60Dysmetric saccades (HP:0000641)2.30455463
61Bradykinesia (HP:0002067)2.30186331
62Ankle clonus (HP:0011448)2.26964412
63Thickened helices (HP:0000391)2.26178648
64Papilledema (HP:0001085)2.25746264
65Impaired vibratory sensation (HP:0002495)2.23619608
66Agitation (HP:0000713)2.22046097
67Generalized myoclonic seizures (HP:0002123)2.21018622
68Hydroureter (HP:0000072)2.19585951
69Abnormality of the corticospinal tract (HP:0002492)2.17160708
70Blue irides (HP:0000635)2.15288565
71Spastic gait (HP:0002064)2.14238577
72Fetal akinesia sequence (HP:0001989)2.14042619
73Morphological abnormality of the pyramidal tract (HP:0002062)2.13288195
74Intention tremor (HP:0002080)2.12343047
75Polyphagia (HP:0002591)2.11784415
76Fair hair (HP:0002286)2.08984099
77Inappropriate behavior (HP:0000719)2.08036705
78Torticollis (HP:0000473)2.06221218
79Focal dystonia (HP:0004373)2.04454100
80Confusion (HP:0001289)2.04422613
81Akinesia (HP:0002304)2.02891528
82Generalized hypopigmentation of hair (HP:0011358)2.02579717
83Gait ataxia (HP:0002066)2.02558553
84Incomplete penetrance (HP:0003829)2.01435301
85Amyotrophic lateral sclerosis (HP:0007354)2.00035690
86Specific learning disability (HP:0001328)1.98415826
87Gait imbalance (HP:0002141)1.98240993
88Exotropia (HP:0000577)1.97247281
89Psychosis (HP:0000709)1.96526873
90Widely spaced teeth (HP:0000687)1.92389297
91Lower limb asymmetry (HP:0100559)1.92012304
92Septo-optic dysplasia (HP:0100842)1.91808934
93Optic nerve hypoplasia (HP:0000609)1.89700034
94Lower limb amyotrophy (HP:0007210)1.87320777
95Abnormality of the labia minora (HP:0012880)1.86174596
96Annular pancreas (HP:0001734)1.85733922
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84380929
98Lower limb muscle weakness (HP:0007340)1.84149320
99Megalencephaly (HP:0001355)1.82951943
100Spastic tetraplegia (HP:0002510)1.82941625
101Tetraplegia (HP:0002445)1.82794334
102Hemiplegia (HP:0002301)1.82699962
103Ventricular fibrillation (HP:0001663)1.81779940
104Gastroesophageal reflux (HP:0002020)1.81460692
105Methylmalonic acidemia (HP:0002912)1.81261730
106Autism (HP:0000717)1.80464438
107Obstructive sleep apnea (HP:0002870)1.78312200
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.77932501
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77932501
110Clumsiness (HP:0002312)1.76251639
111Deep palmar crease (HP:0006191)1.76021763
112Rapidly progressive (HP:0003678)1.75866736
113Testicular atrophy (HP:0000029)1.74761164
114Retinal dysplasia (HP:0007973)1.73081191
115Deeply set eye (HP:0000490)1.72993716
116Aqueductal stenosis (HP:0002410)1.71757170
117CNS hypomyelination (HP:0003429)1.71054083
118Ankyloglossia (HP:0010296)1.70434079
119Craniofacial dystonia (HP:0012179)1.70415625
120Split foot (HP:0001839)1.69462338
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66036441
122Hepatoblastoma (HP:0002884)1.65616309
123Choreoathetosis (HP:0001266)1.59447785
124Cutaneous finger syndactyly (HP:0010554)1.58570248
125Restlessness (HP:0000711)1.57877586
126Genital tract atresia (HP:0001827)1.57876674
127Peripheral hypomyelination (HP:0007182)1.57779662
128Increased circulating renin level (HP:0000848)1.56963521
129Vaginal atresia (HP:0000148)1.55935392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.82382759
2NTRK34.94750904
3RIPK43.74095885
4MAP3K93.35086423
5MAP3K42.87174294
6CASK2.56595269
7DAPK22.52052061
8MAP2K72.49023954
9MINK12.46409445
10MARK12.12410387
11DAPK12.10099281
12PNCK2.06835266
13KSR22.06735173
14MAP3K122.02655120
15KSR11.98412331
16PLK21.94653754
17MAP2K41.89412236
18PAK61.78255573
19BMPR21.69976878
20NTRK11.64998465
21MAP3K131.63227111
22ARAF1.54075317
23NTRK21.49959452
24PTK2B1.48439939
25SIK21.46493945
26GRK51.44195995
27CDK51.43823727
28CAMKK11.43791155
29TNIK1.39036191
30CDK191.36067818
31PRPF4B1.34665354
32FES1.25871581
33PRKCG1.25020093
34PRKD31.23804257
35CAMK2A1.23656083
36RAF11.22453501
37FRK1.19008677
38CAMK2B1.18819001
39CAMKK21.13656736
40MAPK131.06903738
41STK381.02918619
42FGR1.01697944
43MAP3K21.01653475
44FGFR20.97697806
45NME10.96078967
46DYRK20.93655254
47CAMK10.85547175
48MAP4K20.84191275
49CDK180.81594833
50TYRO30.78203001
51CDK150.77133535
52OXSR10.76693880
53PKN10.76494703
54CDK140.76001806
55SGK10.74534944
56DYRK1A0.72937940
57CSNK1G30.72446095
58UHMK10.69637595
59STK110.68369336
60SIK30.68331847
61CDK11A0.67251161
62CSNK1G10.65383665
63CCNB10.62845628
64CSNK1A1L0.62447411
65SGK2230.62300048
66SGK4940.62300048
67LATS20.62134475
68GRK10.61619802
69RET0.60335157
70ALK0.60247154
71DMPK0.59406673
72AKT30.58932598
73CAMK2D0.57759126
74SGK20.56766430
75PDK10.56488472
76PAK30.56318003
77WNK10.55120858
78PDPK10.53485330
79PRKCE0.52450229
80GRK60.50311438
81MAP3K60.50175262
82FER0.50164487
83MARK20.50079912
84CSNK1A10.49269996
85PRKG10.48615801
86CSNK1G20.48065918
87CSNK1E0.47984106
88MAP3K10.46547592
89NEK60.45344815
90BRAF0.45287320
91MAP2K10.45208710
92PRKACA0.44706090
93CSNK1D0.44261980
94MAP3K70.43987001
95CAMK2G0.42857090
96PRKCZ0.42527081
97CAMK1G0.42191475
98FYN0.41715679
99PINK10.41617308
100PRKCA0.40159971
101BCR0.39968266
102TRIM280.39036897
103TAOK10.38900929
104RPS6KA30.38671036
105TNK20.38255922
106MAPK100.38223870
107ROCK20.37404271
108SGK30.37346973
109PRKCH0.37249530
110MAPK120.37039348
111DAPK30.35788633
112MKNK20.35778713
113PRKCQ0.34429617
114GRK70.33913017
115ERBB20.33811786
116INSRR0.33785172
117ADRBK20.33241000
118BMPR1B0.33186723
119WNK30.32865983
120PHKG10.32346574
121PHKG20.32346574
122MOS0.31495341
123STK390.31314920
124GSK3B0.29707076
125CAMK40.29562678
126PRKDC0.29401409
127PRKCB0.28953011
128MAPK80.27793258

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.24001886
2Long-term potentiation_Homo sapiens_hsa047203.30827363
3Amphetamine addiction_Homo sapiens_hsa050312.93456310
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92832000
5Circadian entrainment_Homo sapiens_hsa047132.88281506
6Glutamatergic synapse_Homo sapiens_hsa047242.82895949
7Synaptic vesicle cycle_Homo sapiens_hsa047212.74353153
8Morphine addiction_Homo sapiens_hsa050322.53987438
9GABAergic synapse_Homo sapiens_hsa047272.51092911
10Olfactory transduction_Homo sapiens_hsa047402.50244203
11Salivary secretion_Homo sapiens_hsa049702.44409956
12Dopaminergic synapse_Homo sapiens_hsa047282.32314165
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11169442
14Renin secretion_Homo sapiens_hsa049242.02592425
15Taste transduction_Homo sapiens_hsa047421.97141070
16Long-term depression_Homo sapiens_hsa047301.95409220
17Gastric acid secretion_Homo sapiens_hsa049711.91638315
18Insulin secretion_Homo sapiens_hsa049111.90037396
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88105929
20Calcium signaling pathway_Homo sapiens_hsa040201.85667335
21Cholinergic synapse_Homo sapiens_hsa047251.84809902
22Serotonergic synapse_Homo sapiens_hsa047261.84601506
23Oxytocin signaling pathway_Homo sapiens_hsa049211.83289006
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59229076
25Cocaine addiction_Homo sapiens_hsa050301.58528492
26GnRH signaling pathway_Homo sapiens_hsa049121.50764330
27Collecting duct acid secretion_Homo sapiens_hsa049661.49274672
28cAMP signaling pathway_Homo sapiens_hsa040241.36177561
29Gap junction_Homo sapiens_hsa045401.35658301
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35408499
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29442406
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23455986
33Axon guidance_Homo sapiens_hsa043601.21174255
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18339028
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16534590
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15283574
37Glioma_Homo sapiens_hsa052141.14518318
38Estrogen signaling pathway_Homo sapiens_hsa049151.12716831
39Melanogenesis_Homo sapiens_hsa049161.11105906
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10124480
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07212915
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03971670
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.02443234
44Type II diabetes mellitus_Homo sapiens_hsa049301.01676218
45Pancreatic secretion_Homo sapiens_hsa049720.99716923
46Cardiac muscle contraction_Homo sapiens_hsa042600.97613724
47ErbB signaling pathway_Homo sapiens_hsa040120.95860653
48Oocyte meiosis_Homo sapiens_hsa041140.95656338
49Phototransduction_Homo sapiens_hsa047440.94836942
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94447798
51Vitamin B6 metabolism_Homo sapiens_hsa007500.88941190
52VEGF signaling pathway_Homo sapiens_hsa043700.85959795
53Vibrio cholerae infection_Homo sapiens_hsa051100.85328530
54Choline metabolism in cancer_Homo sapiens_hsa052310.84464637
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81153672
56African trypanosomiasis_Homo sapiens_hsa051430.80084916
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.77814901
58Thyroid hormone synthesis_Homo sapiens_hsa049180.76115941
59Dorso-ventral axis formation_Homo sapiens_hsa043200.74242606
60Alzheimers disease_Homo sapiens_hsa050100.73988809
61MAPK signaling pathway_Homo sapiens_hsa040100.68493704
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68247490
63Glucagon signaling pathway_Homo sapiens_hsa049220.66787354
64Dilated cardiomyopathy_Homo sapiens_hsa054140.64772554
65Ras signaling pathway_Homo sapiens_hsa040140.58745351
66Parkinsons disease_Homo sapiens_hsa050120.58241064
67Rap1 signaling pathway_Homo sapiens_hsa040150.57995008
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56002136
69Butanoate metabolism_Homo sapiens_hsa006500.55888767
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55434909
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55291872
72Nitrogen metabolism_Homo sapiens_hsa009100.53361652
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.50986366
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.50336900
75Wnt signaling pathway_Homo sapiens_hsa043100.48739516
76Inositol phosphate metabolism_Homo sapiens_hsa005620.48269839
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47664488
78beta-Alanine metabolism_Homo sapiens_hsa004100.44655720
79Circadian rhythm_Homo sapiens_hsa047100.44488691
80Alcoholism_Homo sapiens_hsa050340.44134807
81mTOR signaling pathway_Homo sapiens_hsa041500.41129376
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41096313
83Non-small cell lung cancer_Homo sapiens_hsa052230.39368472
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38776940
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38557432
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37516169
87Oxidative phosphorylation_Homo sapiens_hsa001900.37078930
88Prion diseases_Homo sapiens_hsa050200.36794489
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.34504339
90Fatty acid biosynthesis_Homo sapiens_hsa000610.34055163
91Hippo signaling pathway_Homo sapiens_hsa043900.33830285
92Huntingtons disease_Homo sapiens_hsa050160.33630053
93Regulation of autophagy_Homo sapiens_hsa041400.32554209
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32418627
95Bile secretion_Homo sapiens_hsa049760.32174776
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31227582
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30978525
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30857510
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28957060
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28009070
101Renal cell carcinoma_Homo sapiens_hsa052110.27921621
102Endocytosis_Homo sapiens_hsa041440.26807700
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26108354
104Chemokine signaling pathway_Homo sapiens_hsa040620.25635893
105Hedgehog signaling pathway_Homo sapiens_hsa043400.25233964
106Type I diabetes mellitus_Homo sapiens_hsa049400.24444623
107Insulin signaling pathway_Homo sapiens_hsa049100.23812115
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23714385
109Ovarian steroidogenesis_Homo sapiens_hsa049130.21510062
110Platelet activation_Homo sapiens_hsa046110.21242829
111Histidine metabolism_Homo sapiens_hsa003400.21176905
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20806234
113Mineral absorption_Homo sapiens_hsa049780.20571732
114Melanoma_Homo sapiens_hsa052180.20519158
115Tight junction_Homo sapiens_hsa045300.20298594
116Arginine and proline metabolism_Homo sapiens_hsa003300.20138617
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18704733
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18456970
119Endometrial cancer_Homo sapiens_hsa052130.17755943
120Propanoate metabolism_Homo sapiens_hsa006400.17496192
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16454276

Most similar genes based on co-expression Upload to Enrichr

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