CNN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1galactose catabolic process (GO:0019388)5.33019930
2actin filament depolymerization (GO:0030042)5.29499257
3extracellular matrix assembly (GO:0085029)5.27375063
4chondrocyte proliferation (GO:0035988)5.25468891
5hypotonic response (GO:0006971)5.10513631
6sequestering of extracellular ligand from receptor (GO:0035581)5.05906125
7Golgi transport vesicle coating (GO:0048200)4.75134095
8COPI coating of Golgi vesicle (GO:0048205)4.75134095
9actin-myosin filament sliding (GO:0033275)4.61055176
10muscle filament sliding (GO:0030049)4.61055176
11positive regulation of actin filament depolymerization (GO:0030836)4.36826758
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.32996698
13actin-mediated cell contraction (GO:0070252)4.27772916
14wound healing, spreading of epidermal cells (GO:0035313)4.24939308
15epithelial cell-cell adhesion (GO:0090136)4.20776564
16myofibril assembly (GO:0030239)4.19911637
17cell adhesion mediated by integrin (GO:0033627)4.11788932
18urinary tract smooth muscle contraction (GO:0014848)4.11229560
19collagen fibril organization (GO:0030199)4.10656384
20protein retention in ER lumen (GO:0006621)4.09624995
21cell migration involved in heart development (GO:0060973)4.08248304
22apoptotic cell clearance (GO:0043277)3.89909441
23cardiac muscle cell development (GO:0055013)3.86958911
24sarcomere organization (GO:0045214)3.79476042
25platelet aggregation (GO:0070527)3.79107748
26positive regulation of endothelial cell apoptotic process (GO:2000353)3.78061377
27tonic smooth muscle contraction (GO:0014820)3.72932026
28endodermal cell differentiation (GO:0035987)3.72047877
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.71532934
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.66659121
31protein localization to cell surface (GO:0034394)3.66401580
32negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.65712583
33cardiac cell development (GO:0055006)3.65122602
34regulation of the force of heart contraction (GO:0002026)3.60833813
35endocardial cushion development (GO:0003197)3.59329175
36regulation of tight junction assembly (GO:2000810)3.57616417
37positive regulation of epithelial to mesenchymal transition (GO:0010718)3.55301861
38growth hormone secretion (GO:0030252)3.53853095
39cGMP-mediated signaling (GO:0019934)3.53334954
40protein heterotrimerization (GO:0070208)3.53303327
41wound healing, spreading of cells (GO:0044319)3.51237823
42atrioventricular valve morphogenesis (GO:0003181)3.50937725
43regulation of skeletal muscle contraction (GO:0014819)3.50795895
44actin filament-based movement (GO:0030048)3.49045201
45relaxation of smooth muscle (GO:0044557)3.48679016
46fibroblast migration (GO:0010761)3.44100460
47metanephric mesenchyme development (GO:0072075)3.41791003
48stress fiber assembly (GO:0043149)3.39123222
49cardiac myofibril assembly (GO:0055003)3.37950186
50cardiac muscle hypertrophy (GO:0003300)3.37648080
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.36858814
52regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.35503956
53extracellular fibril organization (GO:0043206)3.32440325
54branching involved in prostate gland morphogenesis (GO:0060442)3.32258043
55kidney mesenchyme development (GO:0072074)3.31504923
56galactose metabolic process (GO:0006012)3.29739475
57fibril organization (GO:0097435)3.28570324
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28292947
59positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.24702479
60striated muscle hypertrophy (GO:0014897)3.20832246
61skin morphogenesis (GO:0043589)3.19484483
62UDP-N-acetylglucosamine metabolic process (GO:0006047)3.18184718
63atrial septum morphogenesis (GO:0060413)3.17452299
64peptidyl-proline hydroxylation (GO:0019511)3.16744181
65vascular smooth muscle contraction (GO:0014829)3.16137593
66bone trabecula formation (GO:0060346)3.14264813
67negative regulation of fatty acid transport (GO:2000192)3.13552019
68cell-substrate junction assembly (GO:0007044)3.08268862
69response to parathyroid hormone (GO:0071107)3.05247436
70endothelial cell morphogenesis (GO:0001886)3.05120383
71regulation of cardiac muscle cell apoptotic process (GO:0010665)3.02622122
72outflow tract septum morphogenesis (GO:0003148)3.01728032
73cardiac chamber formation (GO:0003207)2.99074163
74negative regulation of striated muscle cell apoptotic process (GO:0010664)2.98633514
75regulation of SMAD protein import into nucleus (GO:0060390)2.97926998
76positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97802838
77cellular response to vitamin (GO:0071295)2.96923907
78platelet degranulation (GO:0002576)2.95447084
79positive regulation of SMAD protein import into nucleus (GO:0060391)2.95410946
80cardiac muscle adaptation (GO:0014887)2.95318510
81cardiac muscle hypertrophy in response to stress (GO:0014898)2.95318510
82muscle hypertrophy in response to stress (GO:0003299)2.95318510
83glomerular basement membrane development (GO:0032836)2.94784995
84collagen metabolic process (GO:0032963)2.94343710
85muscle hypertrophy (GO:0014896)2.94251351
86adhesion of symbiont to host cell (GO:0044650)2.93460902
87virion attachment to host cell (GO:0019062)2.93460902
88regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.92074633
89regulation of transforming growth factor beta2 production (GO:0032909)2.91396096
90positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91232161
91muscle tissue morphogenesis (GO:0060415)2.91177913
92smooth muscle tissue development (GO:0048745)2.91121456
93cyclooxygenase pathway (GO:0019371)2.91030616
94regulation of macrophage cytokine production (GO:0010935)2.90135324
95* actomyosin structure organization (GO:0031032)2.87652795
96protein hydroxylation (GO:0018126)2.87434548
97cardiac muscle contraction (GO:0060048)2.86162562
98basement membrane organization (GO:0071711)2.86148239
99vascular endothelial growth factor signaling pathway (GO:0038084)2.85349145
100substrate adhesion-dependent cell spreading (GO:0034446)2.85271602
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85231138
102regulation of receptor binding (GO:1900120)2.84424393
103adult heart development (GO:0007512)2.84124457
104cardiac muscle tissue development (GO:0048738)2.84002019
105adhesion of symbiont to host (GO:0044406)2.83678037
106gland morphogenesis (GO:0022612)2.82980357
107regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.82283972
108multicellular organismal macromolecule metabolic process (GO:0044259)2.82087276
109uterus development (GO:0060065)2.81752692
110mesodermal cell differentiation (GO:0048333)2.80814302
111positive regulation of natural killer cell differentiation (GO:0032825)2.80208323
112cell communication by electrical coupling (GO:0010644)2.79767367
113artery development (GO:0060840)2.78979639
114ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.78774944
115collagen catabolic process (GO:0030574)2.78283144
116paraxial mesoderm development (GO:0048339)2.77947773
117positive regulation of cardiac muscle cell differentiation (GO:2000727)2.77893901
118prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.77199021
119negative regulation of myotube differentiation (GO:0010832)2.75061601
120muscle system process (GO:0003012)2.73772083
121cellular response to interferon-alpha (GO:0035457)2.72084551
122glomerular filtration (GO:0003094)2.71552674
123regulation of cardiac muscle cell differentiation (GO:2000725)2.71522648
124negative regulation of protein localization to cell surface (GO:2000009)2.71389484
125cardiac ventricle formation (GO:0003211)2.70540399
126cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.70427976
127positive regulation of macrophage activation (GO:0043032)2.70013153
128multicellular organismal metabolic process (GO:0044236)2.69725644
129endocrine hormone secretion (GO:0060986)2.69543483
130trabecula formation (GO:0060343)2.69472597
131lymphangiogenesis (GO:0001946)2.69186098
132focal adhesion assembly (GO:0048041)2.68443990
133cell-substrate adherens junction assembly (GO:0007045)2.68443990
134pathway-restricted SMAD protein phosphorylation (GO:0060389)2.68030558
135regulation of integrin-mediated signaling pathway (GO:2001044)2.67804164
136COPII vesicle coating (GO:0048208)2.67252142
137activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67034436
138multicellular organismal catabolic process (GO:0044243)2.66390210
139retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65824732
140regulation of cardioblast differentiation (GO:0051890)2.65596327
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.65406443
142keratan sulfate catabolic process (GO:0042340)2.65122791
143negative regulation of smooth muscle cell migration (GO:0014912)2.63857971
144muscle contraction (GO:0006936)2.62173488
145cardiac muscle tissue morphogenesis (GO:0055008)2.61968204
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61659859
147adherens junction assembly (GO:0034333)2.61363623
148smooth muscle contraction (GO:0006939)2.61327496
149desmosome organization (GO:0002934)2.59997313
150positive regulation of cardiac muscle tissue development (GO:0055025)2.59982321
151regulation of cardiac muscle tissue development (GO:0055024)2.58726467
152heart trabecula formation (GO:0060347)2.58360216
153renal filtration (GO:0097205)2.54884137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.25936265
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.55457528
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.66998470
4CLOCK_20551151_ChIP-Seq_293T_Human3.66843970
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.58808075
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40026900
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.28404297
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.66941104
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.61482015
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.54983546
11SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.53490579
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.51738829
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.42272677
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.40136362
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.36437894
16SOX2_20726797_ChIP-Seq_SW620_Human2.30354508
17CJUN_26792858_Chip-Seq_BT549_Human2.23558045
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22677914
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.18609424
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17802687
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17802687
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13296515
23PPAR_26484153_Chip-Seq_NCI-H1993_Human2.05514382
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.01192882
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.98907784
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.97883081
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96844367
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95721700
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95669534
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95009094
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.92006527
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88915999
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87194255
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86764064
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86764064
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.86735567
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85369820
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.82378073
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82269226
40EZH2_22144423_ChIP-Seq_EOC_Human1.77208554
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76686390
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.75923456
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72224233
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70110137
45BRD4_25478319_ChIP-Seq_HGPS_Human1.67845576
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67806687
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66206669
48GBX2_23144817_ChIP-Seq_PC3_Human1.66200202
49RACK7_27058665_Chip-Seq_MCF-7_Human1.63767813
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.61929266
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61628105
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59788547
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56692119
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.56047715
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54985090
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51845785
57* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51226292
58* ATF3_27146783_Chip-Seq_COLON_Human1.50626914
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50202451
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49421983
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48208944
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48208944
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46491055
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.46420960
65TP53_22127205_ChIP-Seq_IMR90_Human1.45565088
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.45141458
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45047719
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44537335
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.44527718
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.44527718
71DROSHA_22980978_ChIP-Seq_HELA_Human1.44054077
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43771396
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42599428
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42191975
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40663215
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40453754
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36642121
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.36586776
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35452440
80GATA4_25053715_ChIP-Seq_YYC3_Human1.34883718
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34857671
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34688920
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34023550
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30638029
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30011009
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29405944
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27598587
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.24857133
89* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24470490
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24172352
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24169866
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23903512
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22980263
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.20876854
95* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20267071
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20108647
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19241276
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17497079
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16951128
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.15163677
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15082757
102GATA3_24758297_ChIP-Seq_MCF-7_Human1.13853504
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13010561
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.11876170
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10912871
106SMAD4_21799915_ChIP-Seq_A2780_Human1.10719139
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.10172577
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09538616
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.09426449
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09231362
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09085063
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.08227886
113AHR_22903824_ChIP-Seq_MCF-7_Human1.07865686
114* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07653899
115* SMAD4_21741376_ChIP-Seq_HESCs_Human1.05416748
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05164540
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05125510
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02115754
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01973917
120GATA6_25053715_ChIP-Seq_YYC3_Human1.01902780
121* UBF1/2_26484160_Chip-Seq_HMECs_Human1.01860938
122KLF5_25053715_ChIP-Seq_YYC3_Human1.01062352
123EOMES_21245162_ChIP-Seq_HESCs_Human1.00847400
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00479899
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00283249
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97586043
127GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96426352
128ZNF263_19887448_ChIP-Seq_K562_Human0.96346574
129TP53_18474530_ChIP-ChIP_U2OS_Human0.95425556
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95207499
131EGR1_19374776_ChIP-ChIP_THP-1_Human0.94947404
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.94276246
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.93139718
134TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91643314
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91453069
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91370809
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91249665
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91224123
139TP53_16413492_ChIP-PET_HCT116_Human0.91151636
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90203068
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90164461
142CTCF_27219007_Chip-Seq_Bcells_Human0.89975895
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.89666531
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.89203988
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88376367
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88124997
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86056344
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86026054
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85741852
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85478113
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.85053935
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84939875
153ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82266919
154IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81600041
155VDR_22108803_ChIP-Seq_LS180_Human0.81595499
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81257166
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81103196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.51571409
2MP0010386_abnormal_urinary_bladder3.66239884
3MP0005275_abnormal_skin_tensile3.44232379
4MP0003705_abnormal_hypodermis_morpholog3.26666607
5MP0000516_abnormal_urinary_system3.07701395
6MP0005367_renal/urinary_system_phenotyp3.07701395
7MP0006054_spinal_hemorrhage2.98114276
8MP0003566_abnormal_cell_adhesion2.93396017
9MP0003279_aneurysm2.79420218
10MP0010352_gastrointestinal_tract_polyps2.76792027
11MP0001958_emphysema2.60560618
12MP0005503_abnormal_tendon_morphology2.57913761
13MP0004084_abnormal_cardiac_muscle2.52612535
14MP0004272_abnormal_basement_membrane2.44144652
15MP0008004_abnormal_stomach_pH2.42969935
16MP0000013_abnormal_adipose_tissue2.38921935
17MP0004036_abnormal_muscle_relaxation2.20422637
18MP0009384_cardiac_valve_regurgitation2.20288088
19MP0005023_abnormal_wound_healing2.05091062
20MP0005330_cardiomyopathy1.96054315
21MP0004215_abnormal_myocardial_fiber1.87395408
22MP0000750_abnormal_muscle_regeneration1.85481406
23MP0000537_abnormal_urethra_morphology1.78594050
24MP0002108_abnormal_muscle_morphology1.77741262
25MP0005620_abnormal_muscle_contractility1.76034837
26MP0000462_abnormal_digestive_system1.73001587
27MP0002295_abnormal_pulmonary_circulatio1.70594279
28MP0003283_abnormal_digestive_organ1.68756552
29MP0000534_abnormal_ureter_morphology1.66116378
30MP0001664_abnormal_digestion1.66069274
31MP0000749_muscle_degeneration1.64207240
32MP0001542_abnormal_bone_strength1.63658614
33MP0005623_abnormal_meninges_morphology1.62935304
34MP0001756_abnormal_urination1.61304133
35MP0002837_dystrophic_cardiac_calcinosis1.60972789
36MP0002127_abnormal_cardiovascular_syste1.57648719
37MP0003091_abnormal_cell_migration1.56956325
38MP0010234_abnormal_vibrissa_follicle1.54694463
39MP0000767_abnormal_smooth_muscle1.44236867
40MP0003950_abnormal_plasma_membrane1.42312992
41MP0003385_abnormal_body_wall1.40899186
42MP0003045_fibrosis1.40854267
43MP0004145_abnormal_muscle_electrophysio1.40687358
44MP0004085_abnormal_heartbeat1.36003675
45MP0003941_abnormal_skin_development1.35565244
46MP0000230_abnormal_systemic_arterial1.34402162
47MP0006138_congestive_heart_failure1.34378077
48MP0002972_abnormal_cardiac_muscle1.33212508
49MP0002060_abnormal_skin_morphology1.31705460
50MP0003137_abnormal_impulse_conducting1.31344693
51MP0004087_abnormal_muscle_fiber1.28108128
52MP0010368_abnormal_lymphatic_system1.23440996
53MP0000538_abnormal_urinary_bladder1.20716394
54MP0009780_abnormal_chondrocyte_physiolo1.20218796
55MP0001879_abnormal_lymphatic_vessel1.19115302
56MP0005508_abnormal_skeleton_morphology1.18203235
57MP0000049_abnormal_middle_ear1.16690132
58MP0000751_myopathy1.16337978
59MP0003300_gastrointestinal_ulcer1.16318804
60MP0008775_abnormal_heart_ventricle1.15426910
61MP0005595_abnormal_vascular_smooth1.15286921
62MP0005257_abnormal_intraocular_pressure1.12102701
63MP0010630_abnormal_cardiac_muscle1.08779485
64MP0000003_abnormal_adipose_tissue1.07394992
65MP0001348_abnormal_lacrimal_gland1.06836658
66MP0010030_abnormal_orbit_morphology1.06683776
67MP0005369_muscle_phenotype1.02209108
68MP0009053_abnormal_anal_canal0.99598797
69MP0001544_abnormal_cardiovascular_syste0.99556770
70MP0005385_cardiovascular_system_phenoty0.99556770
71MP0000343_altered_response_to0.97274427
72MP0004484_altered_response_of0.96552019
73MP0005670_abnormal_white_adipose0.93260582
74MP0003942_abnormal_urinary_system0.92951771
75MP0009250_abnormal_appendicular_skeleto0.92543318
76MP0005381_digestive/alimentary_phenotyp0.92358716
77MP0002106_abnormal_muscle_physiology0.91092861
78MP0001881_abnormal_mammary_gland0.91020134
79MP0001614_abnormal_blood_vessel0.90865363
80MP0005410_abnormal_fertilization0.90578742
81MP0005375_adipose_tissue_phenotype0.88529028
82MP0002282_abnormal_trachea_morphology0.87266416
83MP0001299_abnormal_eye_distance/0.85926876
84MP0002128_abnormal_blood_circulation0.85413580
85MP0001243_abnormal_dermal_layer0.85239965
86MP0002254_reproductive_system_inflammat0.85120775
87MP0003828_pulmonary_edema0.84097066
88MP0005666_abnormal_adipose_tissue0.83297526
89MP0004510_myositis0.83219647
90MP0004147_increased_porphyrin_level0.82536785
91MP0002896_abnormal_bone_mineralization0.80826430
92MP0002925_abnormal_cardiovascular_devel0.76375410
93MP0000249_abnormal_blood_vessel0.75912482
94MP0003115_abnormal_respiratory_system0.75834071
95MP0001765_abnormal_ion_homeostasis0.75048509
96MP0005166_decreased_susceptibility_to0.73895787
97MP0000762_abnormal_tongue_morphology0.73780628
98MP0002932_abnormal_joint_morphology0.73770629
99MP0002933_joint_inflammation0.73580640
100MP0000733_abnormal_muscle_development0.72604262
101* MP0005164_abnormal_response_to0.70426959
102MP0002269_muscular_atrophy0.70175388
103MP0004134_abnormal_chest_morphology0.69520183
104MP0004858_abnormal_nervous_system0.68680997
105MP0002249_abnormal_larynx_morphology0.68647127
106MP0004185_abnormal_adipocyte_glucose0.68315418
107MP0000627_abnormal_mammary_gland0.67384805
108MP0000266_abnormal_heart_morphology0.67235454
109MP0003315_abnormal_perineum_morphology0.66684399
110MP0001661_extended_life_span0.65985639
111MP0000858_altered_metastatic_potential0.64896488
112MP0000477_abnormal_intestine_morphology0.64033983
113MP0000747_muscle_weakness0.63897863
114MP0001663_abnormal_digestive_system0.63237988
115MP0000428_abnormal_craniofacial_morphol0.62984039
116* MP0005390_skeleton_phenotype0.62863129
117MP0005388_respiratory_system_phenotype0.62724250
118MP0002133_abnormal_respiratory_system0.62724250
119MP0005171_absent_coat_pigmentation0.62558380
120MP0004264_abnormal_extraembryonic_tissu0.62249087
121MP0002168_other_aberrant_phenotype0.62118325
122* MP0002115_abnormal_skeleton_extremities0.61953092
123* MP0000163_abnormal_cartilage_morphology0.61386502
124MP0000759_abnormal_skeletal_muscle0.61110917
125MP0003937_abnormal_limbs/digits/tail_de0.60873333
126MP0001270_distended_abdomen0.57022483
127MP0002234_abnormal_pharynx_morphology0.56875022
128MP0003935_abnormal_craniofacial_develop0.56615835
129MP0000432_abnormal_head_morphology0.55040929

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)9.96890831
2Aortic dissection (HP:0002647)8.59794205
3Papilledema (HP:0001085)5.34597810
4Cerebral aneurysm (HP:0004944)5.29738797
5Facial diplegia (HP:0001349)5.15087321
6Increased density of long bones (HP:0006392)5.07914505
7Premature rupture of membranes (HP:0001788)5.06267947
8Protrusio acetabuli (HP:0003179)4.97667193
9Gastrointestinal dysmotility (HP:0002579)4.74816282
10Right ventricular cardiomyopathy (HP:0011663)4.58443277
11Malnutrition (HP:0004395)4.20913969
12Type 1 muscle fiber predominance (HP:0003803)3.95306195
13Aneurysm (HP:0002617)3.92762726
14Dilatation of the ascending aorta (HP:0005111)3.74584996
15Neoplasm of the heart (HP:0100544)3.64263562
16Ankle contracture (HP:0006466)3.55643049
17Aortic regurgitation (HP:0001659)3.53006362
18Atrial fibrillation (HP:0005110)3.45593930
19Scapular winging (HP:0003691)3.32988128
20Atrophic scars (HP:0001075)3.20909451
21Primary atrial arrhythmia (HP:0001692)3.11049494
22Supraventricular arrhythmia (HP:0005115)3.07588799
23Supraventricular tachycardia (HP:0004755)2.98723813
24Pulmonary artery stenosis (HP:0004415)2.94375860
25Bicuspid aortic valve (HP:0001647)2.92734377
26Abnormality of the calcaneus (HP:0008364)2.91885938
27Neonatal short-limb short stature (HP:0008921)2.91845609
28Bundle branch block (HP:0011710)2.88273079
29Abnormality of abdominal situs (HP:0011620)2.84259379
30Abdominal situs inversus (HP:0003363)2.84259379
31Spinal rigidity (HP:0003306)2.83198388
32Hyporeflexia of lower limbs (HP:0002600)2.81426193
33Peritonitis (HP:0002586)2.78623462
34Soft skin (HP:0000977)2.72940010
35Follicular hyperkeratosis (HP:0007502)2.72128091
36Overgrowth (HP:0001548)2.72123320
37Wormian bones (HP:0002645)2.70706770
38Vascular tortuosity (HP:0004948)2.66545776
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.65997773
40Osteolytic defects of the hand bones (HP:0009699)2.65997773
41Wide anterior fontanel (HP:0000260)2.65735377
42Ulnar bowing (HP:0003031)2.62524807
43Shallow orbits (HP:0000586)2.62279568
44Round ear (HP:0100830)2.60196074
45Genu recurvatum (HP:0002816)2.58024766
46Bradycardia (HP:0001662)2.57567080
47Abnormality of dentin (HP:0010299)2.56989836
48Increased connective tissue (HP:0009025)2.54796263
49Fragile skin (HP:0001030)2.53958286
50Cervical subluxation (HP:0003308)2.52550713
51Radial bowing (HP:0002986)2.52423293
52Arterial tortuosity (HP:0005116)2.48194146
53Sudden death (HP:0001699)2.46697729
54Nemaline bodies (HP:0003798)2.44763192
55Wrist flexion contracture (HP:0001239)2.43262191
56Abnormal pupillary function (HP:0007686)2.43092455
57Mitral valve prolapse (HP:0001634)2.42183850
58Distal arthrogryposis (HP:0005684)2.37566774
59Short hallux (HP:0010109)2.37146943
60Lipoatrophy (HP:0100578)2.35649392
61Elbow flexion contracture (HP:0002987)2.35627007
62Joint laxity (HP:0001388)2.35593002
63Broad ribs (HP:0000885)2.34420431
64Coronal craniosynostosis (HP:0004440)2.33440533
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.32704293
66Ileus (HP:0002595)2.32663586
67Camptodactyly of toe (HP:0001836)2.32618038
68Myopathic facies (HP:0002058)2.32566579
69Broad metatarsal (HP:0001783)2.32516195
70Tarsal synostosis (HP:0008368)2.32357830
71Infantile muscular hypotonia (HP:0008947)2.31521276
72Blue sclerae (HP:0000592)2.31467980
73Limited hip movement (HP:0008800)2.30899339
74Long toe (HP:0010511)2.30597631
75Ectopia lentis (HP:0001083)2.28976346
76Prolonged QT interval (HP:0001657)2.28365937
77Ventricular tachycardia (HP:0004756)2.27268167
78Asymmetric septal hypertrophy (HP:0001670)2.25597197
79Calcaneovalgus deformity (HP:0001848)2.25196542
80Mildly elevated creatine phosphokinase (HP:0008180)2.24594661
81Hypoventilation (HP:0002791)2.24492012
82Hyperparathyroidism (HP:0000843)2.18450258
83Syncope (HP:0001279)2.18340080
84Mesomelia (HP:0003027)2.18281211
85Aplasia/Hypoplasia of the hallux (HP:0008362)2.17961456
86Vertebral compression fractures (HP:0002953)2.17892521
87Bowel diverticulosis (HP:0005222)2.17745438
88Broad face (HP:0000283)2.15190176
89Ulnar deviation of the wrist (HP:0003049)2.11848057
90Knee flexion contracture (HP:0006380)2.10331920
91Neck muscle weakness (HP:0000467)2.10275197
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09317759
93Muscle fiber inclusion bodies (HP:0100299)2.03910303
94Bladder diverticulum (HP:0000015)2.03283789
95Synostosis involving bones of the feet (HP:0009140)2.02974861
96Synostosis involving bones of the lower limbs (HP:0009138)2.02974861
97Abnormality of the shoulder girdle musculature (HP:0001435)2.02384724
98Abnormality of the 2nd finger (HP:0004100)2.01753556
99Persistence of primary teeth (HP:0006335)2.01648776
100Hypoplasia of the iris (HP:0007676)2.01208836
101Spondylolisthesis (HP:0003302)2.00627798
102Mitral regurgitation (HP:0001653)2.00300754
103Deformed tarsal bones (HP:0008119)2.00110564
104Abnormal atrioventricular conduction (HP:0005150)1.98509196
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98079761
106Short 4th metacarpal (HP:0010044)1.98079761
107Muscle fiber splitting (HP:0003555)1.96400776
108Stroke (HP:0001297)1.96245049
109Increased variability in muscle fiber diameter (HP:0003557)1.95245600
110Dilated cardiomyopathy (HP:0001644)1.95216141
111Bowed forearm bones (HP:0003956)1.91537898
112Bowing of the arm (HP:0006488)1.91537898
113Heart block (HP:0012722)1.91107624
114Rectal prolapse (HP:0002035)1.88946242
115Distal lower limb muscle weakness (HP:0009053)1.86593374
116Slender build (HP:0001533)1.86447213
117Abnormal delivery (HP:0001787)1.84144779
118Abnormal EKG (HP:0003115)1.81509642
119Abnormal foot bone ossification (HP:0010675)1.81348723
120Patent foramen ovale (HP:0001655)1.81332025
121Trismus (HP:0000211)1.80093541
122Broad distal phalanx of finger (HP:0009836)1.78528234
123Hip contracture (HP:0003273)1.77881498
124Hyperextensible skin (HP:0000974)1.77699897
125Hydroureter (HP:0000072)1.76951071
126Venous insufficiency (HP:0005293)1.76224368
127Osteoarthritis (HP:0002758)1.75598609
128Back pain (HP:0003418)1.75404589
129Absent phalangeal crease (HP:0006109)1.75221781
130Increased mean platelet volume (HP:0011877)1.75126137
131Upper limb amyotrophy (HP:0009129)1.73474242
132Distal upper limb amyotrophy (HP:0007149)1.73474242
133Abnormality of the acetabulum (HP:0003170)1.73394418
134Abnormality of skeletal muscle fiber size (HP:0012084)1.73313075
135Biconcave vertebral bodies (HP:0004586)1.72513757
136Abnormality of the calf musculature (HP:0001430)1.71038095
137Aortic valve stenosis (HP:0001650)1.70799000
138Lymphangioma (HP:0100764)1.68353198
139Joint stiffness (HP:0001387)1.67765344
140Broad long bones (HP:0005622)1.66209692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK8.72378339
2TTN4.88304956
3TESK13.97397993
4PIK3CG3.58504310
5DMPK3.11947162
6LIMK13.09359797
7PAK23.00103142
8PIK3CA2.66118898
9MAPKAPK32.07651309
10AKT31.96371633
11TRIB31.91359104
12DDR21.82688058
13LATS11.76081515
14CDC42BPA1.72931031
15ERN11.66722523
16DAPK31.61137494
17LATS21.54877059
18STK38L1.54401711
19LMTK21.53370606
20NUAK11.45971811
21OBSCN1.38906660
22FRK1.35598408
23PKN21.32371268
24PDGFRA1.30446742
25EPHB21.28318999
26PTK2B1.28102211
27TIE11.25093479
28TRPM71.24281507
29ROCK11.23962687
30GRK71.23922245
31PAK31.23572281
32ILK1.23295705
33PAK11.15128656
34TESK21.12877514
35EEF2K1.12390674
36PDK21.08644789
37PTK21.08251635
38EPHA31.07920201
39LRRK21.06029670
40FER1.05699043
41RIPK11.03405963
42PRKD21.01653107
43MAP3K60.99389367
44MAP3K70.92882926
45MAP3K30.92455722
46MET0.87483967
47PTK60.84004252
48MST1R0.80933975
49RPS6KB20.80613791
50NLK0.79575226
51MST40.78930773
52EPHA20.78794088
53WNK10.78791840
54TGFBR20.74633520
55RAF10.73619193
56MAP2K10.72149911
57WNK40.71573477
58PIM20.71441320
59STK30.70175259
60ADRBK10.67532355
61MARK20.66499000
62RPS6KA60.66085546
63STK100.64538987
64ZAK0.64167028
65MAPK150.63325778
66MINK10.63296983
67PRKAA20.62016685
68MAPK70.61646854
69SCYL20.59844576
70KDR0.59080471
71CAMK2G0.58623507
72ROCK20.56628311
73KIT0.56134508
74SIK10.55505756
75PRKCE0.53530486
76INSRR0.53183892
77MAPK40.51153086
78PRKAA10.49482189
79MAPK120.47535537
80CAMK1G0.47387632
81MAPKAPK20.45990223
82TAOK30.45812920
83NTRK10.45622493
84BCKDK0.45327542
85KSR20.44177478
86RPS6KA20.44039192
87PRKG20.43446768
88FGFR10.42103554
89MAP2K30.40099393
90STK390.39429636
91MUSK0.39331370
92CAMK40.37216387
93MAP3K80.35885314
94PDK30.34242396
95PDK40.34242396
96MAP3K20.33367593
97CAMK10.33069877
98BMX0.32627221
99PAK40.32476393
100BRSK20.32325538
101FLT30.32132040
102PINK10.31683312
103CAMK2A0.31118770
104MTOR0.29561956
105MAPK10.29466526
106GSK3A0.28988092
107MAPKAPK50.28532789
108PRKG10.28505556
109PRKCH0.27765516
110NEK90.27123225
111SGK4940.26641510
112SGK2230.26641510
113PRKD10.26605867
114DYRK1B0.26458829
115PLK40.26417649
116STK240.25907224
117GRK10.25710592
118INSR0.25174784
119PDGFRB0.25127488
120ARAF0.24520628
121CAMK1D0.24234042
122EGFR0.23957337
123MAP3K100.23913348
124TAOK10.23232155
125PKN10.22916731
126RPS6KA40.22450877
127PRKACB0.22344468
128CAMK2B0.21948360
129MARK10.21195638
130SRC0.20262477
131PRKCI0.19371355
132MOS0.19330691
133EPHB10.14085477
134CAMK2D0.13894446
135JAK30.13433931
136STK380.12995060
137TGFBR10.12839067
138RET0.12811516
139RPS6KL10.12250863
140RPS6KC10.12250863

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.62621921
2Focal adhesion_Homo sapiens_hsa045103.25066072
3Dilated cardiomyopathy_Homo sapiens_hsa054143.19287606
4ECM-receptor interaction_Homo sapiens_hsa045123.16277548
5Vascular smooth muscle contraction_Homo sapiens_hsa042703.16074141
6Bladder cancer_Homo sapiens_hsa052192.43231104
7Sulfur metabolism_Homo sapiens_hsa009202.40967851
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.32310616
9Tight junction_Homo sapiens_hsa045302.24901241
10Proteoglycans in cancer_Homo sapiens_hsa052052.14099277
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.09329275
12TGF-beta signaling pathway_Homo sapiens_hsa043502.08161711
13Adherens junction_Homo sapiens_hsa045202.03206712
14Amoebiasis_Homo sapiens_hsa051461.99174657
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90596890
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.88501069
17Hippo signaling pathway_Homo sapiens_hsa043901.74727666
18Cardiac muscle contraction_Homo sapiens_hsa042601.71275793
19Regulation of actin cytoskeleton_Homo sapiens_hsa048101.68690222
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67244604
21Renin secretion_Homo sapiens_hsa049241.60549169
22Protein digestion and absorption_Homo sapiens_hsa049741.59863503
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58440218
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58015734
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55841956
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47197380
27Small cell lung cancer_Homo sapiens_hsa052221.40939305
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37128593
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35429399
30Hedgehog signaling pathway_Homo sapiens_hsa043401.28571680
31Calcium signaling pathway_Homo sapiens_hsa040201.26747479
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26561276
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25161529
34Shigellosis_Homo sapiens_hsa051311.24283029
35cAMP signaling pathway_Homo sapiens_hsa040241.23389215
36Platelet activation_Homo sapiens_hsa046111.22057001
37N-Glycan biosynthesis_Homo sapiens_hsa005101.16976691
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14601696
39Malaria_Homo sapiens_hsa051441.14062044
40MicroRNAs in cancer_Homo sapiens_hsa052061.12285514
41Insulin secretion_Homo sapiens_hsa049111.08968596
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07915552
43HIF-1 signaling pathway_Homo sapiens_hsa040661.04067087
44Vibrio cholerae infection_Homo sapiens_hsa051101.02907635
45Chronic myeloid leukemia_Homo sapiens_hsa052201.01798546
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00770572
47Circadian entrainment_Homo sapiens_hsa047130.99888674
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98790800
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96055012
50Salivary secretion_Homo sapiens_hsa049700.95988824
51Circadian rhythm_Homo sapiens_hsa047100.95754506
52Mineral absorption_Homo sapiens_hsa049780.94630471
53PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93784545
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93732986
55Oxytocin signaling pathway_Homo sapiens_hsa049210.91787604
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88611057
57Gastric acid secretion_Homo sapiens_hsa049710.85913902
58Arachidonic acid metabolism_Homo sapiens_hsa005900.84793194
59Galactose metabolism_Homo sapiens_hsa000520.83780024
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81568282
61Cholinergic synapse_Homo sapiens_hsa047250.80903873
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80864197
63Ovarian steroidogenesis_Homo sapiens_hsa049130.80791476
64Glutathione metabolism_Homo sapiens_hsa004800.80740368
65Cocaine addiction_Homo sapiens_hsa050300.80498982
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.80283622
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79425047
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79314680
69Other glycan degradation_Homo sapiens_hsa005110.77053787
70Thyroid hormone synthesis_Homo sapiens_hsa049180.77021477
71Dorso-ventral axis formation_Homo sapiens_hsa043200.76472296
72Taste transduction_Homo sapiens_hsa047420.75357065
73Salmonella infection_Homo sapiens_hsa051320.75116372
74PPAR signaling pathway_Homo sapiens_hsa033200.74510625
75Pancreatic cancer_Homo sapiens_hsa052120.74487463
76Axon guidance_Homo sapiens_hsa043600.72497093
77Carbon metabolism_Homo sapiens_hsa012000.69779093
78Pancreatic secretion_Homo sapiens_hsa049720.69270662
79Fructose and mannose metabolism_Homo sapiens_hsa000510.68908818
80Toxoplasmosis_Homo sapiens_hsa051450.68650589
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68507758
82Lysosome_Homo sapiens_hsa041420.66845504
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.66768286
84p53 signaling pathway_Homo sapiens_hsa041150.66722837
85Serotonergic synapse_Homo sapiens_hsa047260.66687503
86Estrogen signaling pathway_Homo sapiens_hsa049150.66568634
87MAPK signaling pathway_Homo sapiens_hsa040100.66065038
88Protein export_Homo sapiens_hsa030600.65261367
89Viral myocarditis_Homo sapiens_hsa054160.62713912
90Thyroid cancer_Homo sapiens_hsa052160.62366974
91Olfactory transduction_Homo sapiens_hsa047400.61612368
92GnRH signaling pathway_Homo sapiens_hsa049120.61323785
93Rap1 signaling pathway_Homo sapiens_hsa040150.59489142
94Pathways in cancer_Homo sapiens_hsa052000.58226247
95Linoleic acid metabolism_Homo sapiens_hsa005910.57772606
96Notch signaling pathway_Homo sapiens_hsa043300.56713163
97Basal cell carcinoma_Homo sapiens_hsa052170.55121736
98Sulfur relay system_Homo sapiens_hsa041220.54956063
99Leishmaniasis_Homo sapiens_hsa051400.53685923
100Melanoma_Homo sapiens_hsa052180.53261972
101Phagosome_Homo sapiens_hsa041450.50685843
102Insulin resistance_Homo sapiens_hsa049310.50620187
103VEGF signaling pathway_Homo sapiens_hsa043700.50441083
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50368905
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.50236696
106Morphine addiction_Homo sapiens_hsa050320.48595206
107AMPK signaling pathway_Homo sapiens_hsa041520.48180007
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47592591
109Phenylalanine metabolism_Homo sapiens_hsa003600.47360411
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46927113
111Amphetamine addiction_Homo sapiens_hsa050310.46526120
112Prostate cancer_Homo sapiens_hsa052150.46148200
113Wnt signaling pathway_Homo sapiens_hsa043100.45960355
114Endometrial cancer_Homo sapiens_hsa052130.45876939
115Lysine degradation_Homo sapiens_hsa003100.45267313
116Endocytosis_Homo sapiens_hsa041440.45181007
117Long-term depression_Homo sapiens_hsa047300.44501420
118Glutamatergic synapse_Homo sapiens_hsa047240.44364306
119Fatty acid biosynthesis_Homo sapiens_hsa000610.43876341
120Bile secretion_Homo sapiens_hsa049760.43813135
121Pyruvate metabolism_Homo sapiens_hsa006200.43629281
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.43122791
123Renin-angiotensin system_Homo sapiens_hsa046140.40314086
124Pertussis_Homo sapiens_hsa051330.39388724
125TNF signaling pathway_Homo sapiens_hsa046680.39385075
126Ras signaling pathway_Homo sapiens_hsa040140.39331080
127Biosynthesis of amino acids_Homo sapiens_hsa012300.39264832
128Glucagon signaling pathway_Homo sapiens_hsa049220.38632212
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37956648
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36070300
131Arginine and proline metabolism_Homo sapiens_hsa003300.35828945
132Choline metabolism in cancer_Homo sapiens_hsa052310.35593648
133FoxO signaling pathway_Homo sapiens_hsa040680.35533761
134GABAergic synapse_Homo sapiens_hsa047270.35130249
135Colorectal cancer_Homo sapiens_hsa052100.34605334
136Gap junction_Homo sapiens_hsa045400.34470750
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34216741
138Apoptosis_Homo sapiens_hsa042100.33622031
139HTLV-I infection_Homo sapiens_hsa051660.32785990
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32662952
141Fatty acid degradation_Homo sapiens_hsa000710.32261854
142mTOR signaling pathway_Homo sapiens_hsa041500.31599844
143Insulin signaling pathway_Homo sapiens_hsa049100.31562610
144Chemical carcinogenesis_Homo sapiens_hsa052040.28508973
145Melanogenesis_Homo sapiens_hsa049160.27695558
146Renal cell carcinoma_Homo sapiens_hsa052110.27515683

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