CNN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.04943655
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.04943655
3modulation by symbiont of host immune response (GO:0052553)5.04943655
4positive regulation by symbiont of host defense response (GO:0052509)5.04943655
5modulation by symbiont of host defense response (GO:0052031)5.04943655
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.04943655
7leukocyte aggregation (GO:0070486)4.34941027
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21091787
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.21091787
10detection of other organism (GO:0098543)4.12567855
11antigen processing and presentation of endogenous antigen (GO:0019883)4.11195542
12neutrophil activation involved in immune response (GO:0002283)4.08916979
13detection of bacterium (GO:0016045)4.07469205
14Arp2/3 complex-mediated actin nucleation (GO:0034314)4.02078832
15negative thymic T cell selection (GO:0045060)3.99929841
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.99482550
17negative T cell selection (GO:0043383)3.92476915
18sequestering of actin monomers (GO:0042989)3.87506114
19positive regulation of gamma-delta T cell activation (GO:0046645)3.85894143
20positive thymic T cell selection (GO:0045059)3.74220188
21respiratory burst (GO:0045730)3.63113350
22ribosomal small subunit assembly (GO:0000028)3.62790461
23regulation of interferon-beta biosynthetic process (GO:0045357)3.46688637
24thymic T cell selection (GO:0045061)3.40050043
25detection of external biotic stimulus (GO:0098581)3.39317254
26response to peptidoglycan (GO:0032494)3.38584666
27macrophage activation involved in immune response (GO:0002281)3.36799474
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31689913
29response to host (GO:0075136)3.31689913
30response to host defenses (GO:0052200)3.31689913
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.28534803
32response to host immune response (GO:0052572)3.28534803
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.26393526
34leukocyte migration involved in inflammatory response (GO:0002523)3.25563340
35cellular extravasation (GO:0045123)3.25554501
36NIK/NF-kappaB signaling (GO:0038061)3.22327828
37negative regulation of interleukin-12 production (GO:0032695)3.21255208
38regulation of B cell receptor signaling pathway (GO:0050855)3.12375510
39viral transcription (GO:0019083)3.11551162
40neutrophil activation (GO:0042119)3.11518378
41positive regulation of lamellipodium assembly (GO:0010592)3.10236133
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09591575
43positive regulation of endothelial cell apoptotic process (GO:2000353)3.08627107
44regulation of T cell tolerance induction (GO:0002664)3.08359926
45morphogenesis of an endothelium (GO:0003159)3.08148340
46endothelial tube morphogenesis (GO:0061154)3.08148340
47negative regulation of leukocyte mediated immunity (GO:0002704)3.02479907
48type I interferon signaling pathway (GO:0060337)3.02147628
49cellular response to type I interferon (GO:0071357)3.02147628
50positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01834052
51response to type I interferon (GO:0034340)3.00680380
52translational termination (GO:0006415)3.00169882
53detection of biotic stimulus (GO:0009595)2.99611022
54immunoglobulin mediated immune response (GO:0016064)2.98346045
55detection of molecule of bacterial origin (GO:0032490)2.96431392
56regulation of gamma-delta T cell differentiation (GO:0045586)2.96286599
57positive regulation of Cdc42 GTPase activity (GO:0043089)2.94821963
58B cell receptor signaling pathway (GO:0050853)2.91976105
59T cell selection (GO:0045058)2.84783503
60positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82762669
61platelet aggregation (GO:0070527)2.82555617
62positive T cell selection (GO:0043368)2.82526186
63negative regulation of T cell mediated immunity (GO:0002710)2.82505379
64chondrocyte proliferation (GO:0035988)2.81935171
65actin nucleation (GO:0045010)2.80763109
66response to interleukin-15 (GO:0070672)2.80367762
67granulocyte activation (GO:0036230)2.80069578
68T cell migration (GO:0072678)2.79430433
69* negative regulation of phagocytosis (GO:0050765)2.76636980
70endodermal cell differentiation (GO:0035987)2.75637455
71tolerance induction (GO:0002507)2.75503721
72cellular response to interleukin-15 (GO:0071350)2.73896819
73T cell costimulation (GO:0031295)2.72592056
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72545626
75positive regulation of lamellipodium organization (GO:1902745)2.72270027
76wound healing, spreading of cells (GO:0044319)2.71295689
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.71263373
78regulation of natural killer cell mediated immunity (GO:0002715)2.71263373
79myeloid cell activation involved in immune response (GO:0002275)2.71128111
80barbed-end actin filament capping (GO:0051016)2.70824428
81lymphocyte costimulation (GO:0031294)2.68226808
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67983604
83negative regulation of cell killing (GO:0031342)2.67983604
84wound healing, spreading of epidermal cells (GO:0035313)2.67959884
85B cell mediated immunity (GO:0019724)2.67800267
86regulation of T cell mediated cytotoxicity (GO:0001914)2.67666242
87regulation of gamma-delta T cell activation (GO:0046643)2.67401515
88regulation of mast cell degranulation (GO:0043304)2.66687149
89response to interferon-alpha (GO:0035455)2.66063366
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64532883
91translational elongation (GO:0006414)2.64276470
92pinocytosis (GO:0006907)2.64175275
93leukocyte cell-cell adhesion (GO:0007159)2.63269329
94SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62753587
953-UTR-mediated mRNA stabilization (GO:0070935)2.61891131
96positive regulation of B cell differentiation (GO:0045579)2.60848383
97leukocyte degranulation (GO:0043299)2.60005631
98negative regulation of interleukin-6 production (GO:0032715)2.59102675
99response to muramyl dipeptide (GO:0032495)2.58551257
100interferon-gamma production (GO:0032609)2.57234105
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56528422
102regulation of leukocyte degranulation (GO:0043300)2.56304645
103regulation of defense response to virus by virus (GO:0050690)2.55960740
104protein targeting to ER (GO:0045047)2.54324056
105positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54302409
106regulation of protein heterodimerization activity (GO:0043497)2.54257104
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54239715
108negative regulation of innate immune response (GO:0045824)2.53245050
109membrane raft organization (GO:0031579)2.53130033
110cotranslational protein targeting to membrane (GO:0006613)2.52365283
111positive regulation of natural killer cell differentiation (GO:0032825)2.52350258
112skin morphogenesis (GO:0043589)2.50728990
113regulation of necroptotic process (GO:0060544)2.50245765
114stress fiber assembly (GO:0043149)2.49858271
115regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49515595
116ribosomal small subunit biogenesis (GO:0042274)2.48877260
117regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46553798
118negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.46142371
119negative regulation of T-helper cell differentiation (GO:0045623)2.46142371
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.45661755
121heterotypic cell-cell adhesion (GO:0034113)2.44929329
122T cell apoptotic process (GO:0070231)2.44554080
123homotypic cell-cell adhesion (GO:0034109)2.44003645
124pentose-phosphate shunt (GO:0006098)2.43927847
125T cell receptor signaling pathway (GO:0050852)2.43924798
126cellular response to zinc ion (GO:0071294)2.43852593
127regulation of alpha-beta T cell proliferation (GO:0046640)2.43105097
128regulation of T cell receptor signaling pathway (GO:0050856)2.42891420
129dendritic cell migration (GO:0036336)2.42743167
130production of molecular mediator involved in inflammatory response (GO:0002532)2.41523343
131viral life cycle (GO:0019058)2.39956936
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39400844
133positive regulation of tolerance induction (GO:0002645)2.39035958
134dendritic cell chemotaxis (GO:0002407)2.38928867
135collagen fibril organization (GO:0030199)2.38805226
136neutrophil mediated immunity (GO:0002446)2.38542183
137regulation of response to interferon-gamma (GO:0060330)2.38431401
138maturation of SSU-rRNA (GO:0030490)2.37870687
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.37423572
140response to laminar fluid shear stress (GO:0034616)2.37185206
141regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.37059892
142regulation of tolerance induction (GO:0002643)2.36267923
143positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36021654
144protein localization to endoplasmic reticulum (GO:0070972)2.34980097
145cellular protein complex disassembly (GO:0043624)2.34809962
146antigen processing and presentation via MHC class Ib (GO:0002475)2.34377743
147positive regulation of interleukin-8 secretion (GO:2000484)2.34156178
148positive regulation of isotype switching (GO:0045830)2.33970655
149hepatocyte apoptotic process (GO:0097284)2.33532011
150protein heterotrimerization (GO:0070208)2.33481133
151positive regulation of alpha-beta T cell proliferation (GO:0046641)2.30999086
152angiogenesis involved in wound healing (GO:0060055)2.30961724
153actin filament depolymerization (GO:0030042)2.29795020
154negative regulation of fatty acid transport (GO:2000192)2.29725163
155translational initiation (GO:0006413)2.29210537
156antigen receptor-mediated signaling pathway (GO:0050851)2.28742055
157positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28396729
158positive regulation of macrophage differentiation (GO:0045651)2.28107290
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28078012
160cell adhesion mediated by integrin (GO:0033627)2.27733697
161regulation of tight junction assembly (GO:2000810)2.22163867
162regulation of isotype switching to IgG isotypes (GO:0048302)2.21658052
163sequestering of extracellular ligand from receptor (GO:0035581)2.21224019
164formation of translation preinitiation complex (GO:0001731)2.20168950
165regulation of B cell differentiation (GO:0045577)2.19805713
166positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.19375860
167substrate-dependent cell migration (GO:0006929)2.19244959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49204189
2E2F7_22180533_ChIP-Seq_HELA_Human3.52871285
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.38232219
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.29479183
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23060617
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.04584033
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68953736
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62766859
9MYC_22102868_ChIP-Seq_BL_Human2.50243736
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42137094
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35455622
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34404724
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30475655
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.24425107
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20014081
16* MAF_26560356_Chip-Seq_TH1_Human2.17737011
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.09995964
18MYB_26560356_Chip-Seq_TH2_Human2.09217624
19VDR_21846776_ChIP-Seq_THP-1_Human2.08648739
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.05168426
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03566456
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.99525573
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98668098
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97894380
25UTX_26944678_Chip-Seq_JUKART_Human1.95527647
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.87247403
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86831394
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86394511
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80733537
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80250986
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77812827
32* SPI1_23547873_ChIP-Seq_NB4_Human1.77118593
33* MYB_26560356_Chip-Seq_TH1_Human1.76573008
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76469072
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70779040
36* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70246194
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67059251
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65301001
39LXR_22292898_ChIP-Seq_THP-1_Human1.65109834
40VDR_24763502_ChIP-Seq_THP-1_Human1.63344861
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61242762
42* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61001746
43RUNX_20019798_ChIP-Seq_JUKART_Human1.60626297
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58241022
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54804470
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52466991
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.51618205
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.51519686
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44743528
50MAF_26560356_Chip-Seq_TH2_Human1.41472707
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41210859
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.40944364
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40869726
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37739503
55TCF7_22412390_ChIP-Seq_EML_Mouse1.37213420
56ELK1_19687146_ChIP-ChIP_HELA_Human1.37014080
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36947969
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35952734
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34920508
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33887616
61XRN2_22483619_ChIP-Seq_HELA_Human1.33502054
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33146996
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32830784
64RACK7_27058665_Chip-Seq_MCF-7_Human1.32121655
65CLOCK_20551151_ChIP-Seq_293T_Human1.31677958
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.31593424
67* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29567594
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28972144
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28025754
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27592061
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26003703
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.24890030
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22597167
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22399527
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.22356874
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20816749
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18893172
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18466850
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.18212183
80* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18096356
81* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18096356
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16971629
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16658111
84* KDM2B_26808549_Chip-Seq_DND41_Human1.15153219
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14241465
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12455361
87TFEB_21752829_ChIP-Seq_HELA_Human1.11787386
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11768095
89* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11745375
90SCL_19346495_ChIP-Seq_HPC-7_Human1.11427188
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.10535025
92VDR_23849224_ChIP-Seq_CD4+_Human1.09929515
93* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09295527
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08804683
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08687374
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08296943
97* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08175836
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08048423
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08043434
100DCP1A_22483619_ChIP-Seq_HELA_Human1.07736023
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07202759
102* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07152012
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07139743
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06444782
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.06380843
106* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05658482
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04515151
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04474134
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04191781
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.03771729
111SPI1_23127762_ChIP-Seq_K562_Human1.02580250
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02439372
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02222878
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01850584
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01569288
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01569288
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01569288
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01379033
119GATA3_27048872_Chip-Seq_THYMUS_Human1.01206887
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00123086
121FOXP3_21729870_ChIP-Seq_TREG_Human0.99951241
122ATF3_27146783_Chip-Seq_COLON_Human0.99786389
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99093686
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98695711
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98619413
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98152321
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98138719
128* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98048080
129BRD4_25478319_ChIP-Seq_HGPS_Human0.96909807
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.96713431
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96684784
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96075824
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95427632
134* NCOR1_26117541_ChIP-Seq_K562_Human0.94656428
135CIITA_25753668_ChIP-Seq_RAJI_Human0.94485494
136* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94330869
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92964729
138* BCL6_27268052_Chip-Seq_Bcells_Human0.91406368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.82893646
2MP0003279_aneurysm2.94254678
3MP0000685_abnormal_immune_system2.58739369
4MP0002254_reproductive_system_inflammat2.45464279
5MP0003763_abnormal_thymus_physiology2.40772177
6MP0001835_abnormal_antigen_presentation2.37417107
7MP0003705_abnormal_hypodermis_morpholog2.32522432
8MP0010352_gastrointestinal_tract_polyps2.31053857
9MP0005275_abnormal_skin_tensile2.27725288
10MP0001958_emphysema2.24979733
11MP0003566_abnormal_cell_adhesion2.15856635
12MP0005671_abnormal_response_to2.07947182
13MP0008260_abnormal_autophagy2.03838097
14MP0003436_decreased_susceptibility_to2.00720729
15MP0005503_abnormal_tendon_morphology1.97225445
16MP0006054_spinal_hemorrhage1.91984517
17MP0002396_abnormal_hematopoietic_system1.90149780
18MP0002933_joint_inflammation1.89125097
19* MP0005023_abnormal_wound_healing1.88357364
20MP0001790_abnormal_immune_system1.85390966
21MP0005387_immune_system_phenotype1.85390966
22MP0009785_altered_susceptibility_to1.83459348
23MP0000858_altered_metastatic_potential1.81380504
24MP0002166_altered_tumor_susceptibility1.79836168
25MP0001800_abnormal_humoral_immune1.77702440
26MP0003191_abnormal_cellular_cholesterol1.76029656
27MP0001849_ear_inflammation1.74816515
28MP0009333_abnormal_splenocyte_physiolog1.74376720
29MP0005000_abnormal_immune_tolerance1.72477176
30MP0002405_respiratory_system_inflammati1.71342749
31MP0004808_abnormal_hematopoietic_stem1.70625640
32* MP0002452_abnormal_antigen_presenting1.68805475
33* MP0002420_abnormal_adaptive_immunity1.67048278
34* MP0001819_abnormal_immune_cell1.65305505
35MP0003091_abnormal_cell_migration1.59077219
36* MP0002398_abnormal_bone_marrow1.59046780
37MP0009384_cardiac_valve_regurgitation1.57002982
38MP0003303_peritoneal_inflammation1.55425795
39MP0002723_abnormal_immune_serum1.54556480
40MP0002148_abnormal_hypersensitivity_rea1.50309057
41MP0005025_abnormal_response_to1.48443038
42MP0005623_abnormal_meninges_morphology1.47200003
43MP0002006_tumorigenesis1.44789740
44MP0001348_abnormal_lacrimal_gland1.41557803
45MP0003724_increased_susceptibility_to1.40749108
46* MP0000716_abnormal_immune_system1.38419618
47MP0004858_abnormal_nervous_system1.38022255
48MP0001533_abnormal_skeleton_physiology1.36117501
49MP0004272_abnormal_basement_membrane1.35173589
50MP0002722_abnormal_immune_system1.34084549
51MP0003448_altered_tumor_morphology1.33008532
52MP0001853_heart_inflammation1.31739447
53MP0008007_abnormal_cellular_replicative1.31092344
54MP0000703_abnormal_thymus_morphology1.30556346
55MP0001243_abnormal_dermal_layer1.30540862
56* MP0002419_abnormal_innate_immunity1.29569398
57MP0003300_gastrointestinal_ulcer1.29539921
58MP0000767_abnormal_smooth_muscle1.29535379
59MP0004510_myositis1.28601227
60MP0010368_abnormal_lymphatic_system1.26295557
61MP0004947_skin_inflammation1.26131542
62MP0000689_abnormal_spleen_morphology1.24794047
63MP0010155_abnormal_intestine_physiology1.24733578
64* MP0002429_abnormal_blood_cell1.21796470
65MP0002877_abnormal_melanocyte_morpholog1.19189587
66MP0001879_abnormal_lymphatic_vessel1.18165852
67MP0004883_abnormal_blood_vessel1.18000335
68MP0010030_abnormal_orbit_morphology1.16654347
69MP0005451_abnormal_body_composition1.16334133
70MP0001851_eye_inflammation1.16268193
71MP0005390_skeleton_phenotype1.09672488
72MP0003828_pulmonary_edema1.09582024
73MP0002060_abnormal_skin_morphology1.08063770
74MP0001545_abnormal_hematopoietic_system1.05732603
75MP0005397_hematopoietic_system_phenotyp1.05732603
76MP0000733_abnormal_muscle_development1.05433345
77MP0005464_abnormal_platelet_physiology1.04336428
78MP0000490_abnormal_crypts_of1.03385531
79MP0001542_abnormal_bone_strength1.03331538
80MP0003077_abnormal_cell_cycle1.02370418
81MP0005164_abnormal_response_to1.00972841
82MP0003866_abnormal_defecation1.00321974
83MP0000343_altered_response_to0.98919041
84MP0005076_abnormal_cell_differentiation0.98488578
85MP0001845_abnormal_inflammatory_respons0.98414462
86MP0004957_abnormal_blastocyst_morpholog0.97868636
87MP0001873_stomach_inflammation0.95998975
88MP0003172_abnormal_lysosome_physiology0.95091943
89MP0005508_abnormal_skeleton_morphology0.94309926
90MP0008469_abnormal_protein_level0.92929720
91MP0003693_abnormal_embryo_hatching0.92380582
92MP0009278_abnormal_bone_marrow0.91435541
93MP0001915_intracranial_hemorrhage0.89863634
94MP0002019_abnormal_tumor_incidence0.88167943
95MP0000465_gastrointestinal_hemorrhage0.87010133
96MP0009053_abnormal_anal_canal0.84471843
97MP0003385_abnormal_body_wall0.83577939
98MP0009764_decreased_sensitivity_to0.83362870
99MP0006082_CNS_inflammation0.81753717
100MP0002295_abnormal_pulmonary_circulatio0.81347556
101MP0003453_abnormal_keratinocyte_physiol0.80737499
102MP0003941_abnormal_skin_development0.79716305
103MP0002128_abnormal_blood_circulation0.79620625
104MP0000249_abnormal_blood_vessel0.78154855
105MP0002998_abnormal_bone_remodeling0.78134335
106MP0003795_abnormal_bone_structure0.77223627
107MP0005621_abnormal_cell_physiology0.77187715
108MP0002132_abnormal_respiratory_system0.76000741
109MP0000350_abnormal_cell_proliferation0.75147948
110MP0001614_abnormal_blood_vessel0.74998800
111MP0005257_abnormal_intraocular_pressure0.74596547
112MP0001175_abnormal_lung_morphology0.73694952
113MP0002925_abnormal_cardiovascular_devel0.73024455
114MP0001663_abnormal_digestive_system0.70707481
115MP0003111_abnormal_nucleus_morphology0.69235216
116MP0009763_increased_sensitivity_to0.68892077
117MP0003045_fibrosis0.68327045
118MP0002796_impaired_skin_barrier0.68230451
119MP0002133_abnormal_respiratory_system0.63602043
120MP0005388_respiratory_system_phenotype0.63602043
121MP0004381_abnormal_hair_follicle0.62032606
122MP0002277_abnormal_respiratory_mucosa0.60511329

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.85373971
2Premature rupture of membranes (HP:0001788)5.10148379
3Aortic dissection (HP:0002647)3.97061724
4Aortic aneurysm (HP:0004942)3.92835271
5Abnormality of macrophages (HP:0004311)3.83872955
6Orchitis (HP:0100796)3.64034762
7Peritonitis (HP:0002586)3.62656588
8Elevated erythrocyte sedimentation rate (HP:0003565)3.48497069
9Dilatation of the ascending aorta (HP:0005111)3.45904809
10Vertebral compression fractures (HP:0002953)3.37767977
11Cerebral aneurysm (HP:0004944)3.26069070
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.15570416
13Eczematoid dermatitis (HP:0000976)3.14121937
14Biconcave vertebral bodies (HP:0004586)3.03518266
15Increased IgE level (HP:0003212)3.02733438
16Gastrointestinal infarctions (HP:0005244)2.99453915
17Shallow orbits (HP:0000586)2.97063726
18Chronic obstructive pulmonary disease (HP:0006510)2.93029456
19Obstructive lung disease (HP:0006536)2.93029456
20Cervical subluxation (HP:0003308)2.91348217
21Meningitis (HP:0001287)2.89539148
22Retrobulbar optic neuritis (HP:0100654)2.88120784
23Optic neuritis (HP:0100653)2.88120784
24Soft skin (HP:0000977)2.86017632
25Atrophic scars (HP:0001075)2.83023077
26Thrombocytosis (HP:0001894)2.80751628
27Ankle contracture (HP:0006466)2.78073504
28Recurrent gram-negative bacterial infections (HP:0005420)2.77775818
29Mediastinal lymphadenopathy (HP:0100721)2.76697982
30Increased density of long bones (HP:0006392)2.75793421
31Recurrent bronchitis (HP:0002837)2.71694160
32Urticaria (HP:0001025)2.68152599
33Recurrent skin infections (HP:0001581)2.64875637
34Myositis (HP:0100614)2.62928604
35Syringomyelia (HP:0003396)2.62484527
36Spinal cord lesions (HP:0100561)2.62484527
37Gingivitis (HP:0000230)2.54103858
38Wormian bones (HP:0002645)2.53676350
39Abnormality of T cell number (HP:0011839)2.49253512
40Recurrent cutaneous fungal infections (HP:0011370)2.49163886
41Chronic mucocutaneous candidiasis (HP:0002728)2.49163886
42Abnormality of dentin (HP:0010299)2.45370123
43Prolonged bleeding time (HP:0003010)2.45180536
44Nonimmune hydrops fetalis (HP:0001790)2.43879142
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.42710908
46Osteolytic defects of the hand bones (HP:0009699)2.42710908
47Recurrent abscess formation (HP:0002722)2.42543266
48Chest pain (HP:0100749)2.40260552
49Blue sclerae (HP:0000592)2.40074686
50T lymphocytopenia (HP:0005403)2.39151941
51Encephalitis (HP:0002383)2.38421767
52Chronic otitis media (HP:0000389)2.37338193
53Abnormality of the nasal mucosa (HP:0000433)2.37038339
54Bladder diverticulum (HP:0000015)2.35254045
55Vasculitis (HP:0002633)2.30762296
56Hypochromic microcytic anemia (HP:0004840)2.29548651
57Disproportionate tall stature (HP:0001519)2.27924582
58Abnormality of T cells (HP:0002843)2.26027422
59Petechiae (HP:0000967)2.25750216
60Recurrent fungal infections (HP:0002841)2.24029517
61IgM deficiency (HP:0002850)2.23421832
62Hypochromic anemia (HP:0001931)2.22302406
63Fragile skin (HP:0001030)2.22131427
64Premature loss of primary teeth (HP:0006323)2.20595433
65Nasal polyposis (HP:0100582)2.20476797
66Mesomelia (HP:0003027)2.19377775
67Keratoconjunctivitis sicca (HP:0001097)2.18178385
68Mitral valve prolapse (HP:0001634)2.16671383
69Gastrointestinal inflammation (HP:0004386)2.16530203
70Wrist flexion contracture (HP:0001239)2.14646362
71Abnormal platelet volume (HP:0011876)2.12381175
72Slender build (HP:0001533)2.11095769
73Emphysema (HP:0002097)2.10920260
74Genu recurvatum (HP:0002816)2.09726885
75Interstitial pulmonary disease (HP:0006530)2.08860500
76Cellulitis (HP:0100658)2.08846421
77Epistaxis (HP:0000421)2.08538436
78Inflammation of the large intestine (HP:0002037)2.08102587
79Skin ulcer (HP:0200042)2.07670430
80Abnormality of the peritoneum (HP:0002585)2.07599033
81Mitral regurgitation (HP:0001653)2.07585692
82Camptodactyly of toe (HP:0001836)2.06678611
83Abnormality of the calcaneus (HP:0008364)2.06677715
84Radial bowing (HP:0002986)2.06135307
85Increased IgM level (HP:0003496)2.06036986
86Broad metatarsal (HP:0001783)2.05574615
87Bicuspid aortic valve (HP:0001647)2.04503670
88Selective tooth agenesis (HP:0001592)2.02923174
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02765580
90Short 4th metacarpal (HP:0010044)2.02765580
91Spontaneous hematomas (HP:0007420)2.00573151
92IgA deficiency (HP:0002720)2.00372937
93Increased mean platelet volume (HP:0011877)2.00145824
94Arterial tortuosity (HP:0005116)1.99725323
95Broad face (HP:0000283)1.99625348
96Vascular tortuosity (HP:0004948)1.99356145
97Pulmonary infiltrates (HP:0002113)1.99002848
98Joint contractures involving the joints of the feet (HP:0100492)1.97535054
99Flexion contracture of toe (HP:0005830)1.97535054
100Abnormality of T cell physiology (HP:0011840)1.96988611
101Recurrent viral infections (HP:0004429)1.96985685
102Abnormality of cells of the lymphoid lineage (HP:0012140)1.96567458
103Keratoconjunctivitis (HP:0001096)1.96242319
104IgG deficiency (HP:0004315)1.95675909
105Panhypogammaglobulinemia (HP:0003139)1.95624115
106Thin bony cortex (HP:0002753)1.94331799
107Spondylolisthesis (HP:0003302)1.94047340
108Lymphopenia (HP:0001888)1.94015242
109Verrucae (HP:0200043)1.93363746
110Papilloma (HP:0012740)1.93363746
111Osteomyelitis (HP:0002754)1.93151744
112Hematochezia (HP:0002573)1.92752596
113Spinal rigidity (HP:0003306)1.92478963
114Reticulocytopenia (HP:0001896)1.91781059
115Persistence of primary teeth (HP:0006335)1.91432978
116Leukocytosis (HP:0001974)1.90727248
117Sepsis (HP:0100806)1.88733930
118Bowel diverticulosis (HP:0005222)1.88361420
119Hypertensive crisis (HP:0100735)1.87440831
120Granulocytopenia (HP:0001913)1.87188211
121Elbow flexion contracture (HP:0002987)1.86759606
122Severe combined immunodeficiency (HP:0004430)1.86641893
123Agammaglobulinemia (HP:0004432)1.86544500
124Metaphyseal cupping (HP:0003021)1.84390841
125Gastrointestinal dysmotility (HP:0002579)1.84341507
126Anorexia (HP:0002039)1.84239968
127Episodic fever (HP:0001954)1.84093931
128Hypergammaglobulinemia (HP:0010702)1.83778039
129Polygenic inheritance (HP:0010982)1.83243904
130Gingival bleeding (HP:0000225)1.81767952
131Aneurysm (HP:0002617)1.79830589
132Abnormality of the pericardium (HP:0001697)1.79371648
133Combined immunodeficiency (HP:0005387)1.78787598
134Short nail (HP:0001799)1.78537126
135Abnormality of the acetabulum (HP:0003170)1.77716836
136Type 1 muscle fiber predominance (HP:0003803)1.76638850
137Stomatitis (HP:0010280)1.75998624
138Ectopia lentis (HP:0001083)1.75817888
139Recurrent bacterial skin infections (HP:0005406)1.75254148
140Neonatal short-limb short stature (HP:0008921)1.74549635
141Joint stiffness (HP:0001387)1.74476502
142Decreased skull ossification (HP:0004331)1.72293363
143Pustule (HP:0200039)1.72045568
144Autoimmune thrombocytopenia (HP:0001973)1.71935109
145Increased connective tissue (HP:0009025)1.70693625
146Eosinophilia (HP:0001880)1.69771635
147Aortic valve stenosis (HP:0001650)1.69730162
148Dislocated radial head (HP:0003083)1.69134509
149Long palpebral fissure (HP:0000637)1.66804687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.29603290
2MAP4K13.21098555
3TESK13.19635067
4SMG12.92068432
5RIPK42.73645691
6KDR2.70282457
7TRIB32.50779113
8TTN2.46958816
9ZAP702.31679428
10PRPF4B2.28129918
11STK102.26191958
12TXK2.23124594
13JAK32.19414251
14NME22.16955567
15LIMK12.10064448
16RPS6KA42.03694308
17LRRK22.02782522
18PKN21.97433950
19MYLK1.93900142
20BLK1.80591566
21PIM21.68971625
22FES1.60756076
23TBK11.59833499
24PRKD21.58321287
25MAP2K31.57264423
26TYK21.53882281
27ERN11.49418169
28SIK31.47420299
29ITK1.46647603
30TRPM71.43690944
31ILK1.35435454
32CDK191.34498501
33MAP3K141.33954939
34FGR1.33406410
35SIK11.32584592
36MAP3K101.26383388
37IKBKE1.23832946
38TGFBR11.23247601
39TGFBR21.22412061
40KIT1.22192774
41BTK1.20455321
42TNK21.19446898
43CSK1.18745777
44NEK91.18547116
45EIF2AK11.18517884
46TEC1.17837535
47FGFR41.14680290
48FLT31.14020818
49BUB11.12626889
50JAK11.11867248
51PAK41.11684360
52IKBKB1.11526889
53NLK1.06663709
54MAP3K31.03830701
55IRAK41.02289455
56PAK21.01801138
57CDC42BPA1.01400623
58LCK0.99804200
59EEF2K0.99306682
60MAP3K110.98911974
61CLK10.95419996
62MAP3K130.93969285
63DMPK0.93842201
64VRK20.90295837
65MAP3K80.89945138
66HCK0.89839346
67PDGFRA0.88083627
68BMX0.86629257
69MAP3K10.86583712
70GRK60.86583507
71DDR20.85702810
72EPHA30.84884788
73PTK20.83707870
74CDK120.83621061
75TLK10.82355801
76KSR20.80775885
77PIM10.80762864
78CSF1R0.77193663
79PTK60.76041394
80RPS6KB20.74573304
81MST40.74400670
82MARK20.72736110
83DAPK30.70423113
84CHUK0.68694519
85SYK0.66728852
86FGFR10.64124910
87YES10.63289815
88MELK0.62913599
89JAK20.62679922
90FGFR30.61728085
91BRSK20.61303020
92STK380.60672458
93MAP3K60.60277367
94CDK40.60243254
95MAPKAPK20.60003563
96STK240.59742745
97TAOK20.59335047
98PASK0.59041254
99EPHB10.58709185
100MARK30.57447345
101PIK3CG0.56244710
102PRKG20.56027549
103NEK20.55950115
104PIK3CA0.55373043
105LATS20.55310325
106HIPK20.53870007
107PTK2B0.53718212
108PAK10.53162320
109MAP3K70.53040178
110RPS6KC10.52379214
111RPS6KL10.52379214
112TAOK10.52348120
113NUAK10.51545581
114ROCK10.51404470
115MAPKAPK30.51190420
116LYN0.51118544
117WEE10.51014975
118MOS0.50724079
119STK40.49769327
120RPS6KA20.48552209
121DYRK1B0.48092790
122FYN0.47313827
123AURKB0.46245939
124PDGFRB0.45760639
125SCYL20.44882829
126MAP3K120.43018697
127INSR0.42744026
128MAPK70.41308102
129CDK60.40114846
130EPHB20.39323496
131ALK0.39237842
132ACVR1B0.38882743
133CDK70.38803982
134IRAK10.38306648
135RPS6KA60.37686875
136RIPK10.36868134

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.96869683
2Ribosome_Homo sapiens_hsa030102.18927133
3Viral myocarditis_Homo sapiens_hsa054162.10169932
4Shigellosis_Homo sapiens_hsa051312.05234205
5Leishmaniasis_Homo sapiens_hsa051401.95995791
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95484410
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.94912627
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.94226554
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.86551483
10Measles_Homo sapiens_hsa051621.82282893
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81882514
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.78632256
13Antigen processing and presentation_Homo sapiens_hsa046121.75666114
14p53 signaling pathway_Homo sapiens_hsa041151.71408461
15Allograft rejection_Homo sapiens_hsa053301.67287403
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65608469
17DNA replication_Homo sapiens_hsa030301.64835002
18T cell receptor signaling pathway_Homo sapiens_hsa046601.61902871
19Staphylococcus aureus infection_Homo sapiens_hsa051501.60101841
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54507279
21Hematopoietic cell lineage_Homo sapiens_hsa046401.54283322
22Malaria_Homo sapiens_hsa051441.47129481
23Proteasome_Homo sapiens_hsa030501.46506113
24Focal adhesion_Homo sapiens_hsa045101.46207528
25Graft-versus-host disease_Homo sapiens_hsa053321.42439772
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39547088
27Adherens junction_Homo sapiens_hsa045201.37801897
28Toxoplasmosis_Homo sapiens_hsa051451.37702624
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37237177
30Small cell lung cancer_Homo sapiens_hsa052221.36738864
31Apoptosis_Homo sapiens_hsa042101.34180854
32Herpes simplex infection_Homo sapiens_hsa051681.33163308
33Osteoclast differentiation_Homo sapiens_hsa043801.32650788
34HTLV-I infection_Homo sapiens_hsa051661.32032870
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31512501
36ECM-receptor interaction_Homo sapiens_hsa045121.26013532
37Base excision repair_Homo sapiens_hsa034101.25618264
38B cell receptor signaling pathway_Homo sapiens_hsa046621.24642327
39TNF signaling pathway_Homo sapiens_hsa046681.23043999
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.22697383
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21601035
42Proteoglycans in cancer_Homo sapiens_hsa052051.19043240
43Phagosome_Homo sapiens_hsa041451.18198283
44Chronic myeloid leukemia_Homo sapiens_hsa052201.17826101
45Hepatitis B_Homo sapiens_hsa051611.16647575
46Platelet activation_Homo sapiens_hsa046111.15542393
47Cell cycle_Homo sapiens_hsa041101.14852418
48Autoimmune thyroid disease_Homo sapiens_hsa053201.12148157
49Mismatch repair_Homo sapiens_hsa034301.11383452
50Salmonella infection_Homo sapiens_hsa051321.10065902
51Epstein-Barr virus infection_Homo sapiens_hsa051691.08684286
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08010209
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05867176
54Viral carcinogenesis_Homo sapiens_hsa052031.05160819
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04785535
56Spliceosome_Homo sapiens_hsa030401.04710659
57Pancreatic cancer_Homo sapiens_hsa052121.04708312
58Legionellosis_Homo sapiens_hsa051341.02694494
59Other glycan degradation_Homo sapiens_hsa005111.01934251
60MicroRNAs in cancer_Homo sapiens_hsa052061.01377007
61Acute myeloid leukemia_Homo sapiens_hsa052211.01127397
62Bladder cancer_Homo sapiens_hsa052191.00682012
63Nucleotide excision repair_Homo sapiens_hsa034200.99935718
64Type I diabetes mellitus_Homo sapiens_hsa049400.98728104
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96388210
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94067325
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93819580
68Influenza A_Homo sapiens_hsa051640.91774695
69African trypanosomiasis_Homo sapiens_hsa051430.88861328
70Homologous recombination_Homo sapiens_hsa034400.88475513
71Pertussis_Homo sapiens_hsa051330.88447432
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.86380408
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85744628
74Endometrial cancer_Homo sapiens_hsa052130.85603878
75Chemokine signaling pathway_Homo sapiens_hsa040620.85319251
76Amoebiasis_Homo sapiens_hsa051460.81952652
77RNA transport_Homo sapiens_hsa030130.81474810
78Renal cell carcinoma_Homo sapiens_hsa052110.80166551
79TGF-beta signaling pathway_Homo sapiens_hsa043500.80009915
80Asthma_Homo sapiens_hsa053100.78167629
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76578417
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74541707
83Tuberculosis_Homo sapiens_hsa051520.73794001
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72642889
85VEGF signaling pathway_Homo sapiens_hsa043700.72525532
86Hippo signaling pathway_Homo sapiens_hsa043900.72413668
87Colorectal cancer_Homo sapiens_hsa052100.72307614
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71651832
89Pentose phosphate pathway_Homo sapiens_hsa000300.71593678
90Pathways in cancer_Homo sapiens_hsa052000.70201932
91Dilated cardiomyopathy_Homo sapiens_hsa054140.69914723
92Thyroid cancer_Homo sapiens_hsa052160.69759053
93HIF-1 signaling pathway_Homo sapiens_hsa040660.66721525
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64235745
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63718398
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.63619301
97Rap1 signaling pathway_Homo sapiens_hsa040150.62941160
98One carbon pool by folate_Homo sapiens_hsa006700.62167253
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61898726
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.59656272
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.56481771
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.55919180
103Endocytosis_Homo sapiens_hsa041440.53064688
104RNA polymerase_Homo sapiens_hsa030200.53048329
105Hepatitis C_Homo sapiens_hsa051600.52602612
106Galactose metabolism_Homo sapiens_hsa000520.52245217
107Pyrimidine metabolism_Homo sapiens_hsa002400.51903668
108Prostate cancer_Homo sapiens_hsa052150.51874739
109FoxO signaling pathway_Homo sapiens_hsa040680.50026200
110Notch signaling pathway_Homo sapiens_hsa043300.48890234
111RNA degradation_Homo sapiens_hsa030180.48697389
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47560328
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46118113
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44554347
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44230772
116Prolactin signaling pathway_Homo sapiens_hsa049170.44217580
117Non-small cell lung cancer_Homo sapiens_hsa052230.44175266
118MAPK signaling pathway_Homo sapiens_hsa040100.43829698
119Protein export_Homo sapiens_hsa030600.42171657
120Choline metabolism in cancer_Homo sapiens_hsa052310.42065693
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41733365
122Lysosome_Homo sapiens_hsa041420.40544053
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40108646

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