CNN2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.76177918
2Arp2/3 complex-mediated actin nucleation (GO:0034314)6.56358964
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.38449565
4cytidine metabolic process (GO:0046087)5.73212783
5cytidine catabolic process (GO:0006216)5.73212783
6cytidine deamination (GO:0009972)5.73212783
7sequestering of actin monomers (GO:0042989)5.68533221
8actin nucleation (GO:0045010)5.39162376
9proteasome assembly (GO:0043248)5.14391956
10pyrimidine ribonucleoside catabolic process (GO:0046133)5.09201476
11negative regulation of stress fiber assembly (GO:0051497)4.51209708
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31473825
13negative regulation of phagocytosis (GO:0050765)4.24655593
14cytolysis (GO:0019835)3.98648855
15response to interferon-beta (GO:0035456)3.91894854
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85967873
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.84011315
18regulation of natural killer cell mediated immunity (GO:0002715)3.84011315
19positive regulation of natural killer cell mediated immunity (GO:0002717)3.82604783
20ATP synthesis coupled proton transport (GO:0015986)3.72887162
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72887162
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69534468
23regulation of cellular amino acid metabolic process (GO:0006521)3.69054626
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.67098748
25cellular response to interferon-beta (GO:0035458)3.60529466
26T cell receptor signaling pathway (GO:0050852)3.58592677
27protein deneddylation (GO:0000338)3.57095493
28negative T cell selection (GO:0043383)3.55254086
29positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.54150037
30positive regulation of lamellipodium assembly (GO:0010592)3.53450827
31antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.53415843
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.51680725
33negative regulation of cell killing (GO:0031342)3.50135693
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.50135693
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48177341
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47402065
37B cell mediated immunity (GO:0019724)3.46395102
38protein neddylation (GO:0045116)3.44628900
39regulation of leukocyte mediated cytotoxicity (GO:0001910)3.35383036
40regulation of B cell receptor signaling pathway (GO:0050855)3.35281284
41negative regulation of T cell apoptotic process (GO:0070233)3.35056361
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34952851
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34952851
44negative regulation of actin filament bundle assembly (GO:0032232)3.34358563
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28244707
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28244707
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28244707
48mannosylation (GO:0097502)3.28165367
49positive regulation of gamma-delta T cell activation (GO:0046645)3.27760440
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26745157
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26745157
52negative thymic T cell selection (GO:0045060)3.26676608
53mitochondrial calcium ion transport (GO:0006851)3.26509618
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26137209
55antigen processing and presentation via MHC class Ib (GO:0002475)3.23569686
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23477082
57cullin deneddylation (GO:0010388)3.20398204
58interferon-gamma production (GO:0032609)3.16238514
59antigen receptor-mediated signaling pathway (GO:0050851)3.13416558
60signal transduction involved in DNA damage checkpoint (GO:0072422)3.07124228
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07124228
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06464725
63negative regulation of ligase activity (GO:0051352)3.06464725
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.06385797
65regulation of isotype switching to IgG isotypes (GO:0048302)3.05746334
66regulation of T cell receptor signaling pathway (GO:0050856)3.03995005
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03933310
68positive regulation of cell killing (GO:0031343)3.03571018
69immunoglobulin mediated immune response (GO:0016064)2.97851907
70regulation of T cell tolerance induction (GO:0002664)2.97485705
71xenobiotic catabolic process (GO:0042178)2.97083743
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94824787
73positive regulation of T cell cytokine production (GO:0002726)2.94283521
74purine deoxyribonucleotide catabolic process (GO:0009155)2.92579420
75piRNA metabolic process (GO:0034587)2.92322064
76regulation of cell killing (GO:0031341)2.90317983
77chaperone-mediated protein transport (GO:0072321)2.88914872
78water-soluble vitamin biosynthetic process (GO:0042364)2.87945381
79anterograde synaptic vesicle transport (GO:0048490)2.87281554
80respiratory electron transport chain (GO:0022904)2.86986998
81pyrimidine nucleoside catabolic process (GO:0046135)2.84857714
82positive thymic T cell selection (GO:0045059)2.84577782
83T cell migration (GO:0072678)2.83724061
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82247384
85regulation of T cell mediated cytotoxicity (GO:0001914)2.80943560
86negative regulation of viral genome replication (GO:0045071)2.80113497
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79338243
88electron transport chain (GO:0022900)2.78623891
89positive regulation of tolerance induction (GO:0002645)2.78174927
90vitamin transmembrane transport (GO:0035461)2.77855072
91leukocyte aggregation (GO:0070486)2.77840792
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77767428
93estrogen biosynthetic process (GO:0006703)2.77510587
94pyrimidine-containing compound transmembrane transport (GO:0072531)2.75875820
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75826743
96cellular defense response (GO:0006968)2.72194504
97positive regulation of lamellipodium organization (GO:1902745)2.70501330
98DNA catabolic process, exonucleolytic (GO:0000738)2.70131126
99regulation of gamma-delta T cell differentiation (GO:0045586)2.69825369
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69046738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human5.68909495
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.58308904
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.93493702
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.88385287
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.65858134
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17133672
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08746793
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07319182
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.94606095
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94510178
11VDR_23849224_ChIP-Seq_CD4+_Human2.82942896
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78147949
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.69118545
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.63000106
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62939801
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59411740
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44219918
18MYB_26560356_Chip-Seq_TH2_Human2.23252662
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21730533
20VDR_22108803_ChIP-Seq_LS180_Human2.11094305
21ELK1_19687146_ChIP-ChIP_HELA_Human2.08596210
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.05632299
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00226109
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00020283
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99512350
26GATA3_26560356_Chip-Seq_TH2_Human1.96692817
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93535414
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.87119268
29FOXP3_21729870_ChIP-Seq_TREG_Human1.83898645
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.83097743
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80219962
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78622150
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75238037
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74372187
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72926522
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72163141
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63166768
38ZNF274_21170338_ChIP-Seq_K562_Hela1.62014699
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.60858620
40SPI1_23547873_ChIP-Seq_NB4_Human1.59374283
41RUNX_20019798_ChIP-Seq_JUKART_Human1.58664612
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50921772
43GATA3_27048872_Chip-Seq_THYMUS_Human1.48878504
44UTX_26944678_Chip-Seq_JUKART_Human1.45504982
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44205515
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.43397642
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41552117
48E2F7_22180533_ChIP-Seq_HELA_Human1.37496655
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32076565
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.29392081
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27893251
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.25041285
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22316815
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20524829
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20451193
56CIITA_25753668_ChIP-Seq_RAJI_Human1.20065460
57MYB_26560356_Chip-Seq_TH1_Human1.19725788
58IGF1R_20145208_ChIP-Seq_DFB_Human1.16081585
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15569277
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13806340
61MYC_18940864_ChIP-ChIP_HL60_Human1.12559715
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09985621
63GABP_19822575_ChIP-Seq_HepG2_Human1.09877874
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08805612
65BCL6_27268052_Chip-Seq_Bcells_Human1.08316153
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08216519
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07176709
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06235404
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05602771
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04743029
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04740483
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03312770
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02768638
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00617780
75P300_27268052_Chip-Seq_Bcells_Human1.00066516
76MAF_26560356_Chip-Seq_TH2_Human0.99240035
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98860327
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98630284
79TP53_22573176_ChIP-Seq_HFKS_Human0.97996903
80MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96223636
81NANOG_20526341_ChIP-Seq_ESCs_Human0.94634060
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.93549514
83IRF8_27001747_Chip-Seq_BMDM_Mouse0.93454765
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.93299796
85MAF_26560356_Chip-Seq_TH1_Human0.93110022
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91804245
87AR_20517297_ChIP-Seq_VCAP_Human0.91433190
88HTT_18923047_ChIP-ChIP_STHdh_Human0.88903931
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88220163
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87924680
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87122062
92ERA_21632823_ChIP-Seq_H3396_Human0.86716505
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86568478
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86128117
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.84949326
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83060673
97OCT4_20526341_ChIP-Seq_ESCs_Human0.82253875
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82243141
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82223670
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81973590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.31314173
2MP0009785_altered_susceptibility_to3.28670056
3MP0001835_abnormal_antigen_presentation3.14168991
4MP0003724_increased_susceptibility_to2.92799560
5MP0003252_abnormal_bile_duct2.78956691
6MP0003763_abnormal_thymus_physiology2.68202781
7MP0005000_abnormal_immune_tolerance2.59186639
8MP0005025_abnormal_response_to2.55749955
9MP0005387_immune_system_phenotype2.46272824
10MP0001790_abnormal_immune_system2.46272824
11MP0008004_abnormal_stomach_pH2.45392506
12MP0008875_abnormal_xenobiotic_pharmacok2.38735637
13MP0000685_abnormal_immune_system2.33666227
14MP0002420_abnormal_adaptive_immunity2.33182072
15MP0001800_abnormal_humoral_immune2.29870082
16MP0001819_abnormal_immune_cell2.29291802
17MP0002723_abnormal_immune_serum2.26364462
18MP0009764_decreased_sensitivity_to2.14288334
19MP0002138_abnormal_hepatobiliary_system2.14212443
20MP0002419_abnormal_innate_immunity2.14181751
21MP0003436_decreased_susceptibility_to2.13561599
22MP0002452_abnormal_antigen_presenting2.09775663
23MP0009333_abnormal_splenocyte_physiolog2.05487886
24MP0003011_delayed_dark_adaptation2.02405635
25MP0002148_abnormal_hypersensitivity_rea2.02058133
26MP0008877_abnormal_DNA_methylation1.99989904
27MP0003693_abnormal_embryo_hatching1.98424517
28MP0006082_CNS_inflammation1.93494845
29MP0005084_abnormal_gallbladder_morpholo1.76816588
30MP0002166_altered_tumor_susceptibility1.74685729
31MP0008260_abnormal_autophagy1.73194090
32MP0000716_abnormal_immune_system1.70844350
33MP0003172_abnormal_lysosome_physiology1.70302016
34MP0002405_respiratory_system_inflammati1.66617259
35MP0002398_abnormal_bone_marrow1.65531700
36MP0001845_abnormal_inflammatory_respons1.62247812
37MP0002277_abnormal_respiratory_mucosa1.55491687
38MP0010155_abnormal_intestine_physiology1.50670928
39MP0000689_abnormal_spleen_morphology1.50204231
40MP0008058_abnormal_DNA_repair1.49485388
41MP0002102_abnormal_ear_morphology1.47537014
42MP0000703_abnormal_thymus_morphology1.42076090
43MP0001533_abnormal_skeleton_physiology1.39811958
44MP0002722_abnormal_immune_system1.39178870
45MP0002429_abnormal_blood_cell1.34399159
46MP0008469_abnormal_protein_level1.33572750
47MP0002876_abnormal_thyroid_physiology1.30693024
48MP0005075_abnormal_melanosome_morpholog1.29700779
49MP0000465_gastrointestinal_hemorrhage1.27779555
50MP0002132_abnormal_respiratory_system1.25734081
51MP0005646_abnormal_pituitary_gland1.24826020
52MP0001501_abnormal_sleep_pattern1.23438804
53MP0001986_abnormal_taste_sensitivity1.20793536
54MP0000015_abnormal_ear_pigmentation1.20261195
55MP0003880_abnormal_central_pattern1.20230361
56MP0003878_abnormal_ear_physiology1.18701516
57MP0005377_hearing/vestibular/ear_phenot1.18701516
58MP0005085_abnormal_gallbladder_physiolo1.18588793
59MP0006072_abnormal_retinal_apoptosis1.18082548
60MP0004947_skin_inflammation1.17494817
61MP0009763_increased_sensitivity_to1.15865321
62MP0002006_tumorigenesis1.15763063
63MP0004147_increased_porphyrin_level1.14780652
64MP0002653_abnormal_ependyma_morphology1.10241557
65MP0001905_abnormal_dopamine_level1.08929592
66MP0003866_abnormal_defecation1.08700255
67MP0005464_abnormal_platelet_physiology1.08064087
68MP0002928_abnormal_bile_duct1.04491265
69MP0005645_abnormal_hypothalamus_physiol1.03847319
70MP0002736_abnormal_nociception_after1.02972597
71MP0004381_abnormal_hair_follicle1.00447925
72MP0009765_abnormal_xenobiotic_induced0.99875767
73MP0005365_abnormal_bile_salt0.99307531
74MP0003045_fibrosis0.97782081
75MP0005083_abnormal_biliary_tract0.96510329
76MP0001727_abnormal_embryo_implantation0.94261101
77MP0008872_abnormal_physiological_respon0.92917313
78MP0005379_endocrine/exocrine_gland_phen0.91970155
79MP0003448_altered_tumor_morphology0.90051732
80MP0002822_catalepsy0.89837908
81MP0003806_abnormal_nucleotide_metabolis0.89383810
82MP0003786_premature_aging0.87703851
83MP0004957_abnormal_blastocyst_morpholog0.79606034
84MP0005319_abnormal_enzyme/_coenzyme0.78925303
85MP0003075_altered_response_to0.78656764
86MP0008995_early_reproductive_senescence0.78104313
87MP0002254_reproductive_system_inflammat0.76124520
88MP0005636_abnormal_mineral_homeostasis0.75760916
89MP0001348_abnormal_lacrimal_gland0.74399532
90MP0002163_abnormal_gland_morphology0.73378087
91MP0002095_abnormal_skin_pigmentation0.72298102
92MP0003950_abnormal_plasma_membrane0.70904659
93MP0002837_dystrophic_cardiac_calcinosis0.68426209
94MP0003638_abnormal_response/metabolism_0.68008556
95MP0000490_abnormal_crypts_of0.67510928
96MP0001346_abnormal_lacrimal_gland0.67099164
97MP0001919_abnormal_reproductive_system0.65643698
98MP0002019_abnormal_tumor_incidence0.64529647
99MP0001542_abnormal_bone_strength0.63087158
100MP0000569_abnormal_digit_pigmentation0.62912667

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.45314190
2Elevated erythrocyte sedimentation rate (HP:0003565)4.87626342
3IgG deficiency (HP:0004315)4.53694962
4Aplastic anemia (HP:0001915)4.07361685
5Eosinophilia (HP:0001880)3.82164946
6Abnormality of T cell number (HP:0011839)3.61557151
73-Methylglutaconic aciduria (HP:0003535)3.48928561
8Encephalitis (HP:0002383)3.44863745
9Generalized aminoaciduria (HP:0002909)3.43948193
10Myositis (HP:0100614)3.41095363
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.35134291
12T lymphocytopenia (HP:0005403)3.23835780
13Abnormality of eosinophils (HP:0001879)3.19613439
14Stomatitis (HP:0010280)3.08233627
15Bile duct proliferation (HP:0001408)3.07567294
16Abnormal biliary tract physiology (HP:0012439)3.07567294
17Abnormality of T cells (HP:0002843)2.96371940
18Retrobulbar optic neuritis (HP:0100654)2.92485581
19Optic neuritis (HP:0100653)2.92485581
20Increased intramyocellular lipid droplets (HP:0012240)2.92116546
21Mitochondrial inheritance (HP:0001427)2.91103336
22Granulocytopenia (HP:0001913)2.90483793
23Methylmalonic acidemia (HP:0002912)2.87963466
24Hypergammaglobulinemia (HP:0010702)2.87553465
25Abnormality of B cell number (HP:0010975)2.84510196
26Hepatocellular necrosis (HP:0001404)2.83838675
27Lipid accumulation in hepatocytes (HP:0006561)2.80678830
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76860007
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76860007
30Increased muscle lipid content (HP:0009058)2.74268202
31Hepatic necrosis (HP:0002605)2.66902460
32Increased hepatocellular lipid droplets (HP:0006565)2.65313501
33Autoimmune hemolytic anemia (HP:0001890)2.64886741
34Cerebral palsy (HP:0100021)2.64041744
35Exertional dyspnea (HP:0002875)2.62777222
36IgM deficiency (HP:0002850)2.59753000
37Orchitis (HP:0100796)2.59151172
38Keratoconjunctivitis sicca (HP:0001097)2.57958177
39Abnormality of T cell physiology (HP:0011840)2.53952270
40Autoimmune thrombocytopenia (HP:0001973)2.51466187
41Anorexia (HP:0002039)2.50770391
42Amyotrophic lateral sclerosis (HP:0007354)2.49354904
43B lymphocytopenia (HP:0010976)2.46867655
44Keratoconjunctivitis (HP:0001096)2.46782087
45Chronic diarrhea (HP:0002028)2.46115637
46Leukocytosis (HP:0001974)2.45046962
47Meningitis (HP:0001287)2.42866516
48Hypoproteinemia (HP:0003075)2.42628778
49Acute necrotizing encephalopathy (HP:0006965)2.42603445
50Severe combined immunodeficiency (HP:0004430)2.41825671
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37273336
52Abnormality of macrophages (HP:0004311)2.35100976
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34990386
54Recurrent cutaneous fungal infections (HP:0011370)2.34477537
55Chronic mucocutaneous candidiasis (HP:0002728)2.34477537
56Type I transferrin isoform profile (HP:0003642)2.33473601
57Abnormality of the aortic arch (HP:0012303)2.32810331
58Abnormal mitochondria in muscle tissue (HP:0008316)2.30321450
59Increased CSF lactate (HP:0002490)2.29176534
60Renal Fanconi syndrome (HP:0001994)2.25722161
61Recurrent fungal infections (HP:0002841)2.19354664
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18280993
63Dicarboxylic aciduria (HP:0003215)2.18280993
64Pustule (HP:0200039)2.15032350
65Acute hepatic failure (HP:0006554)2.14789271
66Carpal bone hypoplasia (HP:0001498)2.11774824
67Facial diplegia (HP:0001349)2.10634620
68Pancytopenia (HP:0001876)2.08239237
69Methylmalonic aciduria (HP:0012120)2.07834317
70Petechiae (HP:0000967)2.07736447
71Gangrene (HP:0100758)2.07233368
72Aplasia/hypoplasia of the uterus (HP:0008684)2.07131189
73Cellular immunodeficiency (HP:0005374)2.05129963
74Hypoplasia of the thymus (HP:0000778)2.04498534
75Vasculitis (HP:0002633)2.03980347
76Hemoptysis (HP:0002105)2.03644145
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02611428
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02013091
79Lymphoma (HP:0002665)1.99814827
80Reduced antithrombin III activity (HP:0001976)1.99063546
81Pancreatic cysts (HP:0001737)1.98375872
82Abnormality of cells of the lymphoid lineage (HP:0012140)1.97860426
83Neutropenia (HP:0001875)1.96648957
84Pulmonary infiltrates (HP:0002113)1.96391833
85Keratoconus (HP:0000563)1.94021021
86Increased corneal curvature (HP:0100692)1.94021021
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93983725
88Abnormal protein N-linked glycosylation (HP:0012347)1.93983725
89Abnormal protein glycosylation (HP:0012346)1.93983725
90Abnormal glycosylation (HP:0012345)1.93983725
91Abnormal albumin level (HP:0012116)1.93768310
92Hypoalbuminemia (HP:0003073)1.93768310
93Lymphopenia (HP:0001888)1.93494005
94Abolished electroretinogram (ERG) (HP:0000550)1.92315438
95Combined immunodeficiency (HP:0005387)1.91513642
96Joint swelling (HP:0001386)1.91070734
97Chest pain (HP:0100749)1.89524257
98Hypochromic anemia (HP:0001931)1.88787785
99Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88768815
100Severe visual impairment (HP:0001141)1.87948965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.85054244
2KDR4.58626941
3MAP3K123.85535526
4TXK3.46154255
5TESK12.91634061
6MAP4K22.80645574
7LIMK12.34628076
8MAP4K12.29747126
9VRK22.20272569
10TNK22.18503972
11TLK12.14344279
12CDK192.13179034
13GRK62.08541273
14NUAK11.95554426
15SIK21.84903304
16BCKDK1.84674647
17SRPK11.70917353
18MAP3K111.67494648
19RPS6KA41.57543647
20TRIM281.52912130
21BLK1.50663657
22ZAP701.48611974
23MYLK1.46289295
24SIK31.43948138
25MST41.39530199
26TBK11.37429120
27BCR1.35897564
28OXSR11.34221639
29MAP3K141.20131312
30IRAK41.16456383
31MAP2K61.13144659
32CCNB11.13078899
33TSSK61.11519991
34SCYL21.10728907
35IKBKB1.05523949
36ITK1.03946206
37MAPKAPK31.03832382
38DAPK10.97471777
39IKBKE0.97262725
40BTK0.96902407
41STK390.94153829
42SYK0.92765104
43BUB10.90745874
44ADRBK20.90601721
45FES0.90528572
46GRK70.85185243
47LCK0.82669873
48ACVR1B0.82326749
49EIF2AK30.81247412
50VRK10.80065806
51TEC0.79785530
52CSK0.78710231
53RAF10.73339023
54LYN0.70719096
55MARK30.69385771
56KSR10.66202066
57PAK60.62799162
58ILK0.62027538
59NEK20.59533284
60TAOK30.58973043
61CLK10.58559416
62NEK10.56118099
63GRK10.54524338
64PRKCQ0.53794199
65CSF1R0.52166612
66MAPK130.52008758
67MAP3K130.49559244
68PIM10.48239215
69FGR0.48202484
70STK100.46520525
71ATR0.44170610
72PAK30.43724700
73JAK30.40217796
74RPS6KA50.39292798
75PAK10.38828417
76ERBB30.37704152
77MAP2K70.37389434
78ROCK10.35258291
79WNK40.34834240
80MAPKAPK20.33267072
81HCK0.33234528
82PAK40.33145373
83CHUK0.31906929
84WNK30.31724024
85GRK50.31582739
86ZAK0.30286697
87TRPM70.29405397
88STK240.28911177
89TAOK10.26057721
90STK38L0.25934901
91IGF1R0.24886035
92BRSK20.24121536
93CSNK2A10.23400271
94ABL10.21315786
95PRKCI0.20103801
96AURKB0.19658380
97INSR0.19348769
98PLK40.19160030
99STK160.18458847
100MAPKAPK50.17503401

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.91604010
2Graft-versus-host disease_Homo sapiens_hsa053324.09244705
3Primary immunodeficiency_Homo sapiens_hsa053403.45238146
4Antigen processing and presentation_Homo sapiens_hsa046123.18407561
5Allograft rejection_Homo sapiens_hsa053303.01894499
6Oxidative phosphorylation_Homo sapiens_hsa001902.96630806
7Autoimmune thyroid disease_Homo sapiens_hsa053202.86044004
8Parkinsons disease_Homo sapiens_hsa050122.55374580
9Type I diabetes mellitus_Homo sapiens_hsa049402.41632430
10Asthma_Homo sapiens_hsa053102.25976630
11Protein export_Homo sapiens_hsa030602.09705700
12Shigellosis_Homo sapiens_hsa051312.08933422
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03233011
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99706349
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.82850015
16Sulfur metabolism_Homo sapiens_hsa009201.76090695
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73568859
18Viral myocarditis_Homo sapiens_hsa054161.69587345
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68458607
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64105355
21Huntingtons disease_Homo sapiens_hsa050161.60565051
22Alzheimers disease_Homo sapiens_hsa050101.57247428
23Hematopoietic cell lineage_Homo sapiens_hsa046401.56915674
24T cell receptor signaling pathway_Homo sapiens_hsa046601.53264382
25RNA polymerase_Homo sapiens_hsa030201.50533778
26Regulation of autophagy_Homo sapiens_hsa041401.42222309
27Staphylococcus aureus infection_Homo sapiens_hsa051501.41610616
28Leishmaniasis_Homo sapiens_hsa051401.26029285
29Measles_Homo sapiens_hsa051621.23719204
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19803213
31Rheumatoid arthritis_Homo sapiens_hsa053231.19261669
32Salmonella infection_Homo sapiens_hsa051321.06500422
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06139182
34Peroxisome_Homo sapiens_hsa041461.04731186
35Herpes simplex infection_Homo sapiens_hsa051681.03965956
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.03677963
37Ribosome_Homo sapiens_hsa030101.02710310
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01608928
39Non-homologous end-joining_Homo sapiens_hsa034500.93765527
40Caffeine metabolism_Homo sapiens_hsa002320.92912074
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.89203182
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85856736
43Epstein-Barr virus infection_Homo sapiens_hsa051690.85324731
44Collecting duct acid secretion_Homo sapiens_hsa049660.79404191
45Chemical carcinogenesis_Homo sapiens_hsa052040.78345637
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78142015
47Legionellosis_Homo sapiens_hsa051340.77551034
48Phototransduction_Homo sapiens_hsa047440.74238367
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73788923
50Cardiac muscle contraction_Homo sapiens_hsa042600.73681725
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72464260
52Pyrimidine metabolism_Homo sapiens_hsa002400.72453859
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.72004151
54Retinol metabolism_Homo sapiens_hsa008300.70311180
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68245309
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67917275
57Phagosome_Homo sapiens_hsa041450.66285615
58Fanconi anemia pathway_Homo sapiens_hsa034600.64932823
59Pertussis_Homo sapiens_hsa051330.63468373
60Homologous recombination_Homo sapiens_hsa034400.63316054
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63278213
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62561405
63Tuberculosis_Homo sapiens_hsa051520.61785840
64Purine metabolism_Homo sapiens_hsa002300.60195844
65Osteoclast differentiation_Homo sapiens_hsa043800.59563365
66Sulfur relay system_Homo sapiens_hsa041220.59493204
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59033909
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56361846
69Basal transcription factors_Homo sapiens_hsa030220.55994759
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55229707
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54543330
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52312356
73Spliceosome_Homo sapiens_hsa030400.51808001
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50682143
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50408102
76Propanoate metabolism_Homo sapiens_hsa006400.50168157
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50011632
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48941781
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48775587
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.47783497
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46553639
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46143459
83One carbon pool by folate_Homo sapiens_hsa006700.45477538
84Nitrogen metabolism_Homo sapiens_hsa009100.45094321
85Influenza A_Homo sapiens_hsa051640.44398901
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44080125
87Linoleic acid metabolism_Homo sapiens_hsa005910.44031508
88Malaria_Homo sapiens_hsa051440.41145574
89Apoptosis_Homo sapiens_hsa042100.39808080
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35091362
91Selenocompound metabolism_Homo sapiens_hsa004500.34173990
92Tryptophan metabolism_Homo sapiens_hsa003800.33999691
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32509633
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30701220
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30424482
96Butanoate metabolism_Homo sapiens_hsa006500.30363828
97Toxoplasmosis_Homo sapiens_hsa051450.26785613
98RNA degradation_Homo sapiens_hsa030180.26428139
99Metabolic pathways_Homo sapiens_hsa011000.25815932
100RNA transport_Homo sapiens_hsa030130.23158009

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