CNN2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.71286791
2DNA deamination (GO:0045006)5.99608688
3Arp2/3 complex-mediated actin nucleation (GO:0034314)5.86409762
4cytidine metabolic process (GO:0046087)5.55983172
5cytidine catabolic process (GO:0006216)5.55983172
6cytidine deamination (GO:0009972)5.55983172
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.16637671
8actin nucleation (GO:0045010)5.13332526
9pyrimidine ribonucleoside catabolic process (GO:0046133)5.08155618
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86653714
11negative regulation of phagocytosis (GO:0050765)4.80578437
12negative T cell selection (GO:0043383)4.66475120
13cellular response to interleukin-15 (GO:0071350)4.56185618
14purine deoxyribonucleotide catabolic process (GO:0009155)4.54824756
15negative thymic T cell selection (GO:0045060)4.53513247
16base-excision repair, AP site formation (GO:0006285)4.38504291
17negative regulation of cell killing (GO:0031342)4.10632470
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.10632470
19positive regulation of T cell mediated cytotoxicity (GO:0001916)4.07828497
20positive regulation of gamma-delta T cell activation (GO:0046645)4.04821848
21positive thymic T cell selection (GO:0045059)3.98920911
22regulation of translational termination (GO:0006449)3.94978253
23deoxyribose phosphate catabolic process (GO:0046386)3.75333112
24deoxyribonucleotide catabolic process (GO:0009264)3.70053367
25regulation of T cell mediated cytotoxicity (GO:0001914)3.69783933
26negative regulation of stress fiber assembly (GO:0051497)3.64148009
27response to interleukin-15 (GO:0070672)3.62446253
28metallo-sulfur cluster assembly (GO:0031163)3.58392389
29iron-sulfur cluster assembly (GO:0016226)3.58392389
30regulation of gamma-delta T cell differentiation (GO:0045586)3.52769906
31response to interferon-beta (GO:0035456)3.48057690
32proteasome assembly (GO:0043248)3.46309965
33regulation of B cell receptor signaling pathway (GO:0050855)3.43837966
34positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.42593909
35T cell receptor signaling pathway (GO:0050852)3.42153749
36leukocyte aggregation (GO:0070486)3.41946379
37platelet dense granule organization (GO:0060155)3.40996940
38sequestering of actin monomers (GO:0042989)3.33762830
39positive regulation of T cell mediated immunity (GO:0002711)3.33527680
40thymic T cell selection (GO:0045061)3.33138821
41positive T cell selection (GO:0043368)3.26521356
42regulation of T cell receptor signaling pathway (GO:0050856)3.25783969
43pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23832191
44positive regulation of T cell cytokine production (GO:0002726)3.21273959
45positive regulation of defense response to virus by host (GO:0002230)3.19640991
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.19192113
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.19003829
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17957135
49regulation of interferon-beta biosynthetic process (GO:0045357)3.16977315
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16388291
51negative regulation of telomere maintenance (GO:0032205)3.15053068
52regulation of gamma-delta T cell activation (GO:0046643)3.13786167
53negative regulation of T cell apoptotic process (GO:0070233)3.13679398
54negative regulation of actin filament bundle assembly (GO:0032232)3.12534932
55tolerance induction (GO:0002507)3.11589385
56T cell migration (GO:0072678)3.11583136
57negative regulation of viral genome replication (GO:0045071)3.11169662
58positive regulation of calcium-mediated signaling (GO:0050850)3.10155886
59regulation of alpha-beta T cell proliferation (GO:0046640)3.06858733
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05135878
61water-soluble vitamin biosynthetic process (GO:0042364)3.05116947
62regulation of T cell mediated immunity (GO:0002709)3.05014543
63piRNA metabolic process (GO:0034587)3.03755316
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03343185
65positive regulation of cell killing (GO:0031343)3.02955021
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01712804
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01642084
68antigen receptor-mediated signaling pathway (GO:0050851)3.01109471
69positive regulation of lamellipodium assembly (GO:0010592)3.00288227
70regulation of regulatory T cell differentiation (GO:0045589)2.99530427
71pyrimidine nucleotide catabolic process (GO:0006244)2.96485017
72T cell selection (GO:0045058)2.95675192
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94764363
74regulation of natural killer cell mediated immunity (GO:0002715)2.94764363
75NIK/NF-kappaB signaling (GO:0038061)2.94026173
76immunoglobulin mediated immune response (GO:0016064)2.92352427
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90627983
78positive regulation of macrophage differentiation (GO:0045651)2.89963567
79antigen processing and presentation of endogenous antigen (GO:0019883)2.88256085
80regulation of defense response to virus by host (GO:0050691)2.83326117
81regulation of cellular amino acid metabolic process (GO:0006521)2.82422036
82regulation of cell killing (GO:0031341)2.81039923
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80273327
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80273327
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80273327
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79814516
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79814516
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77965895
89positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.76879909
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75696297
91signal complex assembly (GO:0007172)2.75603020
92regulation of T cell tolerance induction (GO:0002664)2.75482497
93positive regulation of natural killer cell mediated immunity (GO:0002717)2.73950312
94purine deoxyribonucleotide metabolic process (GO:0009151)2.71145231
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.70383512
96B cell mediated immunity (GO:0019724)2.69569752
97regulation of T cell apoptotic process (GO:0070232)2.68859840
98positive regulation of lymphocyte mediated immunity (GO:0002708)2.68837463
99positive regulation of adaptive immune response (GO:0002821)2.68437041
100chaperone mediated protein folding requiring cofactor (GO:0051085)2.66016074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.03241330
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.48540111
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09568360
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71355884
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33524020
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29551836
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.17289728
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.84284715
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.84061174
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78361862
11RUNX_20019798_ChIP-Seq_JUKART_Human2.66583119
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.64566206
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58884441
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58556648
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57691487
16MYB_26560356_Chip-Seq_TH2_Human2.55795933
17VDR_23849224_ChIP-Seq_CD4+_Human2.48324749
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31752238
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.21747846
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20217731
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19260823
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14830027
23GATA3_26560356_Chip-Seq_TH2_Human2.06743987
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02589297
25VDR_22108803_ChIP-Seq_LS180_Human2.00350947
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98917661
27GATA3_27048872_Chip-Seq_THYMUS_Human1.97737226
28FOXP3_21729870_ChIP-Seq_TREG_Human1.96309430
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90582675
30MYB_26560356_Chip-Seq_TH1_Human1.90222800
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88000496
32UTX_26944678_Chip-Seq_JUKART_Human1.86538889
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.85956833
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82069265
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74397107
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.73988615
37SPI1_23547873_ChIP-Seq_NB4_Human1.73786934
38MAF_26560356_Chip-Seq_TH1_Human1.72335234
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.64944691
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61449306
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58295035
42ZNF274_21170338_ChIP-Seq_K562_Hela1.57364835
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55690697
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54403641
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53319162
46IRF1_19129219_ChIP-ChIP_H3396_Human1.52041971
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48352764
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43656802
49BCL6_27268052_Chip-Seq_Bcells_Human1.40947717
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38208540
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.34440770
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32886110
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.32647281
54MAF_26560356_Chip-Seq_TH2_Human1.31056713
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30952085
56FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30936888
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30867542
58CIITA_25753668_ChIP-Seq_RAJI_Human1.30250657
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28059937
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21865601
61GABP_19822575_ChIP-Seq_HepG2_Human1.20109833
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19700598
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19676842
64NANOG_20526341_ChIP-Seq_ESCs_Human1.19499919
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17321707
66MYC_18940864_ChIP-ChIP_HL60_Human1.16001537
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12942054
68RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10186488
69P300_27268052_Chip-Seq_Bcells_Human1.09557851
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07492196
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07209613
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05535037
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03585812
74E2F7_22180533_ChIP-Seq_HELA_Human1.03545285
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03160022
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00775126
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00465044
78GATA3_26560356_Chip-Seq_TH1_Human1.00058379
79BCOR_27268052_Chip-Seq_Bcells_Human0.98998808
80MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98764667
81SPI1_20517297_ChIP-Seq_HL60_Human0.97721324
82CTCF_20526341_ChIP-Seq_ESCs_Human0.97055482
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96884621
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.94883241
85OCT4_20526341_ChIP-Seq_ESCs_Human0.94606126
86DCP1A_22483619_ChIP-Seq_HELA_Human0.94065857
87RAC3_21632823_ChIP-Seq_H3396_Human0.93872390
88ELK1_19687146_ChIP-ChIP_HELA_Human0.93792331
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.93361010
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93229639
91E2F1_20622854_ChIP-Seq_HELA_Human0.92681564
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90809573
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90760902
94TP53_22573176_ChIP-Seq_HFKS_Human0.89933437
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.89547811
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89295696
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.88398142
98RUNX1_22412390_ChIP-Seq_EML_Mouse0.88199910
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87462417
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87367392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.01104363
2MP0003763_abnormal_thymus_physiology3.66564213
3MP0001835_abnormal_antigen_presentation3.30687751
4MP0000685_abnormal_immune_system3.18290455
5MP0003724_increased_susceptibility_to3.13883687
6MP0001800_abnormal_humoral_immune2.98864321
7MP0002148_abnormal_hypersensitivity_rea2.98708255
8MP0005000_abnormal_immune_tolerance2.92527504
9MP0009785_altered_susceptibility_to2.92170374
10MP0003436_decreased_susceptibility_to2.84274156
11MP0003011_delayed_dark_adaptation2.75536115
12MP0002420_abnormal_adaptive_immunity2.63943915
13MP0009333_abnormal_splenocyte_physiolog2.61785808
14MP0001819_abnormal_immune_cell2.59673796
15MP0002723_abnormal_immune_serum2.57498370
16MP0002452_abnormal_antigen_presenting2.54272389
17MP0005387_immune_system_phenotype2.45951176
18MP0001790_abnormal_immune_system2.45951176
19MP0005025_abnormal_response_to2.45071140
20MP0009764_decreased_sensitivity_to2.36935086
21MP0002419_abnormal_innate_immunity2.21728760
22MP0002398_abnormal_bone_marrow2.00689315
23MP0000716_abnormal_immune_system1.97149994
24MP0002166_altered_tumor_susceptibility1.91792760
25MP0001533_abnormal_skeleton_physiology1.89018049
26MP0003806_abnormal_nucleotide_metabolis1.81695203
27MP0002138_abnormal_hepatobiliary_system1.80873514
28MP0003252_abnormal_bile_duct1.80242664
29MP0010155_abnormal_intestine_physiology1.76201253
30MP0002405_respiratory_system_inflammati1.68710264
31MP0000689_abnormal_spleen_morphology1.68139310
32MP0000703_abnormal_thymus_morphology1.67388842
33MP0001845_abnormal_inflammatory_respons1.63600995
34MP0005645_abnormal_hypothalamus_physiol1.57173286
35MP0002722_abnormal_immune_system1.56923093
36MP0002876_abnormal_thyroid_physiology1.56909157
37MP0002429_abnormal_blood_cell1.54925133
38MP0001968_abnormal_touch/_nociception1.53439224
39MP0001501_abnormal_sleep_pattern1.52042114
40MP0002933_joint_inflammation1.51964859
41MP0004947_skin_inflammation1.50657543
42MP0005083_abnormal_biliary_tract1.50143421
43MP0003191_abnormal_cellular_cholesterol1.49373940
44MP0006082_CNS_inflammation1.40287112
45MP0001873_stomach_inflammation1.40036058
46MP0003866_abnormal_defecation1.39116751
47MP0002006_tumorigenesis1.35553196
48MP0002102_abnormal_ear_morphology1.31155958
49MP0002736_abnormal_nociception_after1.24742923
50MP0010030_abnormal_orbit_morphology1.24629056
51MP0009278_abnormal_bone_marrow1.19250722
52MP0002254_reproductive_system_inflammat1.18108183
53MP0009765_abnormal_xenobiotic_induced1.18091011
54MP0008469_abnormal_protein_level1.17834691
55MP0005390_skeleton_phenotype1.15702509
56MP0003183_abnormal_peptide_metabolism1.15480168
57MP0003646_muscle_fatigue1.14969495
58MP0003786_premature_aging1.14966012
59MP0001853_heart_inflammation1.13936057
60MP0005084_abnormal_gallbladder_morpholo1.13743643
61MP0001542_abnormal_bone_strength1.12658318
62MP0003448_altered_tumor_morphology1.10711468
63MP0008058_abnormal_DNA_repair1.08753835
64MP0006072_abnormal_retinal_apoptosis1.08191529
65MP0005365_abnormal_bile_salt1.07474950
66MP0005464_abnormal_platelet_physiology1.07379963
67MP0008877_abnormal_DNA_methylation1.04363259
68MP0009763_increased_sensitivity_to1.02004848
69MP0008872_abnormal_physiological_respon0.94954518
70MP0005503_abnormal_tendon_morphology0.93702765
71MP0005085_abnormal_gallbladder_physiolo0.93232729
72MP0000613_abnormal_salivary_gland0.88374457
73MP0002837_dystrophic_cardiac_calcinosis0.88145391
74MP0000465_gastrointestinal_hemorrhage0.87167357
75MP0008875_abnormal_xenobiotic_pharmacok0.85928721
76MP0000230_abnormal_systemic_arterial0.85915769
77MP0002019_abnormal_tumor_incidence0.84510170
78MP0000858_altered_metastatic_potential0.84427447
79MP0001919_abnormal_reproductive_system0.82399954
80MP0003693_abnormal_embryo_hatching0.81507538
81MP0003880_abnormal_central_pattern0.75759453
82MP0000604_amyloidosis0.75567525
83MP0001905_abnormal_dopamine_level0.75561190
84MP0006054_spinal_hemorrhage0.75095773
85MP0005551_abnormal_eye_electrophysiolog0.72258073
86MP0010386_abnormal_urinary_bladder0.71837652
87MP0000490_abnormal_crypts_of0.71740794
88MP0003950_abnormal_plasma_membrane0.70682350
89MP0002277_abnormal_respiratory_mucosa0.70663244
90MP0002998_abnormal_bone_remodeling0.69698539
91MP0005389_reproductive_system_phenotype0.69248079
92MP0006035_abnormal_mitochondrial_morpho0.66868991
93MP0002693_abnormal_pancreas_physiology0.62328720
94MP0005360_urolithiasis0.59074283
95MP0009643_abnormal_urine_homeostasis0.58864944
96MP0001243_abnormal_dermal_layer0.58668626
97MP0005075_abnormal_melanosome_morpholog0.58300133
98MP0003795_abnormal_bone_structure0.58157387
99MP0001765_abnormal_ion_homeostasis0.56996379
100MP0002136_abnormal_kidney_physiology0.56796111

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.31404039
2Elevated erythrocyte sedimentation rate (HP:0003565)5.30488355
3Stomatitis (HP:0010280)4.63340427
4T lymphocytopenia (HP:0005403)4.54156241
5Aplastic anemia (HP:0001915)4.33811749
6Abnormality of T cell number (HP:0011839)4.17573283
7Increased IgM level (HP:0003496)4.05860774
8Severe combined immunodeficiency (HP:0004430)3.78793599
9Abnormality of T cells (HP:0002843)3.64713997
10Myositis (HP:0100614)3.57046648
11Abnormality of B cell number (HP:0010975)3.33601366
12Cutaneous melanoma (HP:0012056)3.24430690
13Abnormality of T cell physiology (HP:0011840)3.23561074
14Chronic diarrhea (HP:0002028)3.20460760
15B lymphocytopenia (HP:0010976)3.18181558
16Prostate neoplasm (HP:0100787)3.17159552
17Combined immunodeficiency (HP:0005387)3.07727942
18Encephalitis (HP:0002383)3.06850116
19Recurrent abscess formation (HP:0002722)3.02450054
20Methylmalonic aciduria (HP:0012120)3.01120648
21Mesangial abnormality (HP:0001966)2.87659038
22Lymphopenia (HP:0001888)2.86394494
23Abnormality of the prostate (HP:0008775)2.82993034
24IgM deficiency (HP:0002850)2.80593000
25Recurrent fungal infections (HP:0002841)2.80499844
263-Methylglutaconic aciduria (HP:0003535)2.80081975
27Pustule (HP:0200039)2.78669705
28Recurrent bacterial skin infections (HP:0005406)2.77818323
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.76974543
30Dicarboxylic aciduria (HP:0003215)2.64747853
31Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64747853
32Recurrent cutaneous fungal infections (HP:0011370)2.63180162
33Chronic mucocutaneous candidiasis (HP:0002728)2.63180162
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.62895807
35Orchitis (HP:0100796)2.62544475
36Mediastinal lymphadenopathy (HP:0100721)2.62074756
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60474223
38Hypoproteinemia (HP:0003075)2.56682190
39Autoimmune hemolytic anemia (HP:0001890)2.52272958
40Retrobulbar optic neuritis (HP:0100654)2.51254748
41Optic neuritis (HP:0100653)2.51254748
42Attenuation of retinal blood vessels (HP:0007843)2.50086704
43Acute hepatic failure (HP:0006554)2.45735040
44Meningitis (HP:0001287)2.45673677
45Eczematoid dermatitis (HP:0000976)2.45225138
46Thyroiditis (HP:0100646)2.45213248
47Cerebral palsy (HP:0100021)2.44442359
48Recurrent skin infections (HP:0001581)2.43194224
49Methylmalonic acidemia (HP:0002912)2.41569326
50Pancytopenia (HP:0001876)2.40468867
51Pulmonary infiltrates (HP:0002113)2.39061859
52Eosinophilia (HP:0001880)2.37793570
53IgA deficiency (HP:0002720)2.36203205
54Type II lissencephaly (HP:0007260)2.35845051
55Hypergammaglobulinemia (HP:0010702)2.35577292
56Abnormality of eosinophils (HP:0001879)2.35442581
57Recurrent viral infections (HP:0004429)2.33692950
58Panhypogammaglobulinemia (HP:0003139)2.30320616
59Vasculitis (HP:0002633)2.27037805
60Lymphoma (HP:0002665)2.22097399
61Inflammation of the large intestine (HP:0002037)2.21498711
62Obstructive lung disease (HP:0006536)2.20669224
63Chronic obstructive pulmonary disease (HP:0006510)2.20669224
64Recurrent bronchitis (HP:0002837)2.20074462
65Abolished electroretinogram (ERG) (HP:0000550)2.19521545
66Retinal dysplasia (HP:0007973)2.18927510
67Thyroid-stimulating hormone excess (HP:0002925)2.17601475
68Leukocytosis (HP:0001974)2.17114034
69Abnormal albumin level (HP:0012116)2.11298461
70Hypoalbuminemia (HP:0003073)2.11298461
71Petechiae (HP:0000967)2.10396079
72Autoimmune thrombocytopenia (HP:0001973)2.09260774
73Conical tooth (HP:0000698)2.08633406
74Large eyes (HP:0001090)2.04396209
75Urticaria (HP:0001025)2.04077243
76Gastrointestinal inflammation (HP:0004386)2.03355697
77Keratoconjunctivitis (HP:0001096)2.03103457
78Increased IgE level (HP:0003212)2.00024920
79Recurrent sinusitis (HP:0011108)1.98918022
80Keratoconjunctivitis sicca (HP:0001097)1.98498052
81Stomach cancer (HP:0012126)1.98357607
82Agammaglobulinemia (HP:0004432)1.96635644
83Spastic paraparesis (HP:0002313)1.96288996
84Granulocytopenia (HP:0001913)1.93610989
85Palpebral edema (HP:0100540)1.93290341
86Type I transferrin isoform profile (HP:0003642)1.92380867
87Abnormality of macrophages (HP:0004311)1.91146468
88Keratoconus (HP:0000563)1.89193410
89Increased corneal curvature (HP:0100692)1.89193410
90Chest pain (HP:0100749)1.89110949
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87762936
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87762936
93Congenital stationary night blindness (HP:0007642)1.85122386
94Spontaneous hematomas (HP:0007420)1.85037054
95Neutropenia (HP:0001875)1.84326346
96Ketosis (HP:0001946)1.80612091
97Pancreatitis (HP:0001733)1.79655762
98Lissencephaly (HP:0001339)1.79545348
99Skin rash (HP:0000988)1.79344484
100Mitochondrial inheritance (HP:0001427)1.79144378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.48686934
2BCKDK3.43619751
3KDR3.27432625
4TLK12.97910826
5TXK2.94901627
6VRK22.83894311
7ADRBK22.65946466
8ZAK2.52110980
9MAP4K12.35644839
10TESK12.29782935
11NUAK12.13301569
12TAOK32.10034347
13LIMK12.01683798
14GRK61.96518434
15TNK21.86941870
16VRK11.79195065
17IRAK41.76483690
18SCYL21.73127169
19RPS6KA41.58317370
20MAP3K121.57687645
21ZAP701.57398791
22ERN11.53641803
23TBK11.52645552
24FES1.50908018
25ITK1.50788207
26IKBKE1.50650482
27MAPKAPK31.37242018
28BLK1.25450477
29TSSK61.24027181
30CSF1R1.23067124
31SYK1.21374481
32DAPK11.17870493
33MAP4K21.16868762
34IKBKB1.15852115
35PINK11.14600175
36TEC1.14177772
37MYLK1.13330016
38STK101.13141328
39BUB11.11769672
40CSK1.09762437
41SMG11.07627697
42GRK11.04417665
43BTK0.99727411
44MAP3K140.99277595
45PASK0.98591176
46FRK0.91469762
47CDK190.90534891
48CLK10.89433828
49LCK0.89352061
50ADRBK10.88948737
51LYN0.86882647
52GRK70.86640224
53RPS6KA50.86388785
54FGR0.86103893
55JAK10.85435400
56MAP3K110.81711514
57PRKCQ0.81516894
58PAK60.80770677
59TYK20.79806978
60WNK40.71040519
61GRK50.68989443
62JAK30.68583301
63SIK30.61879999
64EIF2AK30.61253396
65AURKA0.57639334
66SRPK10.57460370
67CSNK1G30.56089145
68ATR0.55285243
69ACVR1B0.53018914
70MAPKAPK20.52991278
71MAP2K20.52293833
72HCK0.50901870
73MELK0.49189915
74IRAK10.48418584
75MST40.47483703
76TRIM280.47389596
77BRSK20.46439701
78ILK0.45960608
79BMPR1B0.44273590
80TAOK20.42025915
81MARK30.41591282
82CAMKK20.41263597
83CSNK1G10.39110504
84RIPK40.38129392
85TGFBR10.36811716
86TAF10.35490529
87CSNK1A1L0.34888647
88DAPK30.34702196
89BRSK10.34295588
90CDK90.33974786
91OXSR10.33924288
92INSR0.33370830
93CSNK1A10.31888761
94MAP2K70.31739880
95DYRK20.30941819
96MAPKAPK50.30686497
97CAMKK10.30592855
98ABL10.29378137
99PIM10.28231942
100ERBB30.27594635

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.74915882
2Proteasome_Homo sapiens_hsa030504.12415330
3Graft-versus-host disease_Homo sapiens_hsa053323.73067394
4Allograft rejection_Homo sapiens_hsa053303.48132512
5Autoimmune thyroid disease_Homo sapiens_hsa053203.33870309
6Antigen processing and presentation_Homo sapiens_hsa046123.07940073
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.98181836
8Asthma_Homo sapiens_hsa053102.77221567
9Type I diabetes mellitus_Homo sapiens_hsa049402.41000159
10Viral myocarditis_Homo sapiens_hsa054162.27045248
11Hematopoietic cell lineage_Homo sapiens_hsa046402.10291212
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97692817
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86242152
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63037381
15Sulfur metabolism_Homo sapiens_hsa009201.51537951
16Base excision repair_Homo sapiens_hsa034101.51500139
17Staphylococcus aureus infection_Homo sapiens_hsa051501.49887048
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49860694
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49504738
20T cell receptor signaling pathway_Homo sapiens_hsa046601.48888945
21Shigellosis_Homo sapiens_hsa051311.48004014
22Systemic lupus erythematosus_Homo sapiens_hsa053221.46034672
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.45259270
24Leishmaniasis_Homo sapiens_hsa051401.42645072
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37423824
26Measles_Homo sapiens_hsa051621.36478901
27Oxidative phosphorylation_Homo sapiens_hsa001901.36376266
28Herpes simplex infection_Homo sapiens_hsa051681.35687322
29Rheumatoid arthritis_Homo sapiens_hsa053231.32376208
30Selenocompound metabolism_Homo sapiens_hsa004501.17963843
31Sulfur relay system_Homo sapiens_hsa041221.15405280
32Legionellosis_Homo sapiens_hsa051341.15381175
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07476203
34Fanconi anemia pathway_Homo sapiens_hsa034601.07206363
35Parkinsons disease_Homo sapiens_hsa050121.06606907
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06545870
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04813514
38Phototransduction_Homo sapiens_hsa047441.04585792
39Homologous recombination_Homo sapiens_hsa034400.99587878
40RNA degradation_Homo sapiens_hsa030180.94383067
41Epstein-Barr virus infection_Homo sapiens_hsa051690.93161101
42Protein export_Homo sapiens_hsa030600.92158363
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88046174
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86557638
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83752375
46DNA replication_Homo sapiens_hsa030300.81326738
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80423676
48Malaria_Homo sapiens_hsa051440.78964144
49Osteoclast differentiation_Homo sapiens_hsa043800.77679637
50Pyrimidine metabolism_Homo sapiens_hsa002400.75624326
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75522318
52Tuberculosis_Homo sapiens_hsa051520.71823230
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71252209
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70079454
55Basal transcription factors_Homo sapiens_hsa030220.69171740
56RNA polymerase_Homo sapiens_hsa030200.68642959
57One carbon pool by folate_Homo sapiens_hsa006700.68498472
58Toxoplasmosis_Homo sapiens_hsa051450.66409857
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63875746
60Tryptophan metabolism_Homo sapiens_hsa003800.62583171
61Phagosome_Homo sapiens_hsa041450.61551651
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59829965
63Apoptosis_Homo sapiens_hsa042100.58317208
64Influenza A_Homo sapiens_hsa051640.56421045
65Propanoate metabolism_Homo sapiens_hsa006400.56255382
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53509243
67Peroxisome_Homo sapiens_hsa041460.52430670
68Linoleic acid metabolism_Homo sapiens_hsa005910.52104100
69Salmonella infection_Homo sapiens_hsa051320.51764876
70TNF signaling pathway_Homo sapiens_hsa046680.50784419
71Alzheimers disease_Homo sapiens_hsa050100.50735342
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50566329
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49272182
74Purine metabolism_Homo sapiens_hsa002300.48871736
75HTLV-I infection_Homo sapiens_hsa051660.46292577
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45929038
77Arachidonic acid metabolism_Homo sapiens_hsa005900.44419880
78Huntingtons disease_Homo sapiens_hsa050160.44302128
79Nucleotide excision repair_Homo sapiens_hsa034200.43428281
80Non-homologous end-joining_Homo sapiens_hsa034500.43211469
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.39483146
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39039213
83Endocytosis_Homo sapiens_hsa041440.39015752
84Spliceosome_Homo sapiens_hsa030400.38033962
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37006262
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36742159
87p53 signaling pathway_Homo sapiens_hsa041150.36055011
88Viral carcinogenesis_Homo sapiens_hsa052030.35191410
89Regulation of autophagy_Homo sapiens_hsa041400.34245327
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33232911
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32126866
92Glutathione metabolism_Homo sapiens_hsa004800.29499297
93Pertussis_Homo sapiens_hsa051330.29346399
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.29243308
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29056327
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.28536556
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27439060
98Metabolic pathways_Homo sapiens_hsa011000.24224001
99Chemical carcinogenesis_Homo sapiens_hsa052040.23631382
100RNA transport_Homo sapiens_hsa030130.23300538

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