

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 5.50794758 |
| 2 | purine deoxyribonucleotide catabolic process (GO:0009155) | 5.43088231 |
| 3 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.39287527 |
| 4 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.32580761 |
| 5 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.25347092 |
| 6 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.20820838 |
| 7 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.18890901 |
| 8 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.15473593 |
| 9 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 5.10019767 |
| 10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.97351293 |
| 11 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.68767779 |
| 12 | positive regulation of B cell differentiation (GO:0045579) | 4.63559855 |
| 13 | response to peptidoglycan (GO:0032494) | 4.56524379 |
| 14 | negative regulation of phagocytosis (GO:0050765) | 4.51581683 |
| 15 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.46718221 |
| 16 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.46718221 |
| 17 | modulation by symbiont of host immune response (GO:0052553) | 4.46718221 |
| 18 | positive regulation by symbiont of host defense response (GO:0052509) | 4.46718221 |
| 19 | modulation by symbiont of host defense response (GO:0052031) | 4.46718221 |
| 20 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.46718221 |
| 21 | cytidine metabolic process (GO:0046087) | 4.26932607 |
| 22 | cytidine catabolic process (GO:0006216) | 4.26932607 |
| 23 | cytidine deamination (GO:0009972) | 4.26932607 |
| 24 | neutrophil activation involved in immune response (GO:0002283) | 4.15322234 |
| 25 | response to host immune response (GO:0052572) | 4.13568574 |
| 26 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.13568574 |
| 27 | histamine secretion (GO:0001821) | 4.06876698 |
| 28 | positive regulation of mast cell activation (GO:0033005) | 4.04942328 |
| 29 | actin nucleation (GO:0045010) | 4.00573855 |
| 30 | regulation of mast cell degranulation (GO:0043304) | 3.98336037 |
| 31 | autophagic vacuole fusion (GO:0000046) | 3.95946557 |
| 32 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.87408677 |
| 33 | negative regulation of cell killing (GO:0031342) | 3.87408677 |
| 34 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.86167987 |
| 35 | DNA deamination (GO:0045006) | 3.80451746 |
| 36 | B cell receptor signaling pathway (GO:0050853) | 3.77278923 |
| 37 | cellular extravasation (GO:0045123) | 3.76765886 |
| 38 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.76631046 |
| 39 | positive regulation of mast cell degranulation (GO:0043306) | 3.76631046 |
| 40 | neutrophil mediated immunity (GO:0002446) | 3.71867920 |
| 41 | regulation of B cell differentiation (GO:0045577) | 3.68792466 |
| 42 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.67691179 |
| 43 | positive regulation of antigen processing and presentation (GO:0002579) | 3.66213463 |
| 44 | response to host (GO:0075136) | 3.62432196 |
| 45 | response to host defenses (GO:0052200) | 3.62432196 |
| 46 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.62432196 |
| 47 | immunoglobulin mediated immune response (GO:0016064) | 3.57392924 |
| 48 | regulation of gamma-delta T cell activation (GO:0046643) | 3.54566862 |
| 49 | regulation of antigen processing and presentation (GO:0002577) | 3.53393512 |
| 50 | respiratory burst (GO:0045730) | 3.53322575 |
| 51 | macrophage activation involved in immune response (GO:0002281) | 3.52927117 |
| 52 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.43213067 |
| 53 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.42359549 |
| 54 | negative regulation of interleukin-12 production (GO:0032695) | 3.41670832 |
| 55 | response to pheromone (GO:0019236) | 3.39980779 |
| 56 | deoxyribonucleotide catabolic process (GO:0009264) | 3.36333166 |
| 57 | negative regulation of B cell apoptotic process (GO:0002903) | 3.35928683 |
| 58 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.35225926 |
| 59 | regulation of leukocyte degranulation (GO:0043300) | 3.35131626 |
| 60 | response to muramyl dipeptide (GO:0032495) | 3.34976410 |
| 61 | regulation of mast cell activation (GO:0033003) | 3.34186767 |
| 62 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.26778912 |
| 63 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.25786884 |
| 64 | deoxyribose phosphate catabolic process (GO:0046386) | 3.25687891 |
| 65 | regulation of germinal center formation (GO:0002634) | 3.19182830 |
| 66 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.17840733 |
| 67 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.17172852 |
| 68 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.15878515 |
| 69 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.15747804 |
| 70 | Peyers patch development (GO:0048541) | 3.14167328 |
| 71 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.14167328 |
| 72 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.13811480 |
| 73 | regulation of B cell apoptotic process (GO:0002902) | 3.13758760 |
| 74 | cellular response to exogenous dsRNA (GO:0071360) | 3.11499546 |
| 75 | mature B cell differentiation involved in immune response (GO:0002313) | 3.09808384 |
| 76 | neutrophil activation (GO:0042119) | 3.09746668 |
| 77 | detection of other organism (GO:0098543) | 3.08457742 |
| 78 | detection of molecule of bacterial origin (GO:0032490) | 3.07679149 |
| 79 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.04850162 |
| 80 | negative regulation of telomere maintenance (GO:0032205) | 3.04783347 |
| 81 | organelle membrane fusion (GO:0090174) | 3.01993439 |
| 82 | histamine transport (GO:0051608) | 2.98802878 |
| 83 | negative regulation of interleukin-6 production (GO:0032715) | 2.97968971 |
| 84 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 2.97827329 |
| 85 | detection of bacterium (GO:0016045) | 2.92605352 |
| 86 | microglial cell activation (GO:0001774) | 2.92037351 |
| 87 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 2.91737253 |
| 88 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 2.91737253 |
| 89 | myeloid leukocyte mediated immunity (GO:0002444) | 2.91672034 |
| 90 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 2.91479868 |
| 91 | leukocyte aggregation (GO:0070486) | 2.90509569 |
| 92 | response to interferon-beta (GO:0035456) | 2.89673120 |
| 93 | detection of external biotic stimulus (GO:0098581) | 2.88004589 |
| 94 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.87968321 |
| 95 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.87897137 |
| 96 | myeloid cell activation involved in immune response (GO:0002275) | 2.86385872 |
| 97 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.83325915 |
| 98 | negative regulation of interleukin-1 beta production (GO:0032691) | 2.83185725 |
| 99 | regulation of regulated secretory pathway (GO:1903305) | 2.82300511 |
| 100 | type I interferon signaling pathway (GO:0060337) | 2.82283143 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.97156463 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.51974192 |
| 3 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.41364499 |
| 4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.26334128 |
| 5 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.09492832 |
| 6 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.92795656 |
| 7 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.89597140 |
| 8 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.89408267 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.77375884 |
| 10 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.76608519 |
| 11 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.57703752 |
| 12 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.57041857 |
| 13 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.46409627 |
| 14 | UTX_26944678_Chip-Seq_JUKART_Human | 2.45006079 |
| 15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.42130672 |
| 16 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.36695211 |
| 17 | SPI1_23127762_ChIP-Seq_K562_Human | 2.34587446 |
| 18 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.34116586 |
| 19 | MYB_26560356_Chip-Seq_TH2_Human | 2.33296024 |
| 20 | MAF_26560356_Chip-Seq_TH1_Human | 2.29635265 |
| 21 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.28312534 |
| 22 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.27855935 |
| 23 | MYC_22102868_ChIP-Seq_BL_Human | 2.26939140 |
| 24 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.26834265 |
| 25 | GATA1_22025678_ChIP-Seq_K562_Human | 2.21161564 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.17866063 |
| 27 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.11622626 |
| 28 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.10871771 |
| 29 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.09696538 |
| 30 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 2.03715485 |
| 31 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.01718798 |
| 32 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.01370151 |
| 33 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.01178580 |
| 34 | MYB_26560356_Chip-Seq_TH1_Human | 1.99878036 |
| 35 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.89356739 |
| 36 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.86344812 |
| 37 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.83259791 |
| 38 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.82857346 |
| 39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.81536189 |
| 40 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.80638607 |
| 41 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79981027 |
| 42 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.77042834 |
| 43 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.76662565 |
| 44 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.71930888 |
| 45 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.70403527 |
| 46 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.65964727 |
| 47 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.65797834 |
| 48 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.62653543 |
| 49 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.62478958 |
| 50 | MAF_26560356_Chip-Seq_TH2_Human | 1.60918329 |
| 51 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.60914646 |
| 52 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.60370460 |
| 53 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.54925845 |
| 54 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.51467312 |
| 55 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.49464761 |
| 56 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.47404580 |
| 57 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.47053999 |
| 58 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.43105676 |
| 59 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.41903222 |
| 60 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.41509387 |
| 61 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.41066284 |
| 62 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39891930 |
| 63 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.35565698 |
| 64 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.32816047 |
| 65 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.32161077 |
| 66 | GATA1_19941826_ChIP-Seq_K562_Human | 1.28793178 |
| 67 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.27504052 |
| 68 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.26580704 |
| 69 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.26580082 |
| 70 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25874883 |
| 71 | GATA3_26560356_Chip-Seq_TH2_Human | 1.25098110 |
| 72 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.24948227 |
| 73 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.24714924 |
| 74 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.24339223 |
| 75 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.21586031 |
| 76 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.20133892 |
| 77 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.17997007 |
| 78 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.16142280 |
| 79 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.16104251 |
| 80 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.15218894 |
| 81 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14928801 |
| 82 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.14846964 |
| 83 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.13780202 |
| 84 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.13690205 |
| 85 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.13120990 |
| 86 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.11446158 |
| 87 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.10796338 |
| 88 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.10441949 |
| 89 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.09206371 |
| 90 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.07560645 |
| 91 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.07262525 |
| 92 | P68_20966046_ChIP-Seq_HELA_Human | 1.07198142 |
| 93 | P300_27268052_Chip-Seq_Bcells_Human | 1.05125250 |
| 94 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.03629496 |
| 95 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.02199244 |
| 96 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.01360261 |
| 97 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.00492616 |
| 98 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.99732455 |
| 99 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.99617049 |
| 100 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.99004757 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.67685197 |
| 2 | MP0003436_decreased_susceptibility_to | 3.49866637 |
| 3 | MP0005671_abnormal_response_to | 3.34839073 |
| 4 | MP0003724_increased_susceptibility_to | 3.27881681 |
| 5 | MP0009785_altered_susceptibility_to | 3.09054756 |
| 6 | MP0005025_abnormal_response_to | 2.95438693 |
| 7 | MP0003303_peritoneal_inflammation | 2.92944805 |
| 8 | MP0002419_abnormal_innate_immunity | 2.91255092 |
| 9 | MP0003172_abnormal_lysosome_physiology | 2.78901819 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.78757272 |
| 11 | MP0001800_abnormal_humoral_immune | 2.73117472 |
| 12 | MP0005464_abnormal_platelet_physiology | 2.63162629 |
| 13 | MP0001348_abnormal_lacrimal_gland | 2.60740905 |
| 14 | MP0000685_abnormal_immune_system | 2.60735457 |
| 15 | MP0003191_abnormal_cellular_cholesterol | 2.60406897 |
| 16 | MP0002420_abnormal_adaptive_immunity | 2.57424739 |
| 17 | MP0005387_immune_system_phenotype | 2.57057739 |
| 18 | MP0001790_abnormal_immune_system | 2.57057739 |
| 19 | MP0001819_abnormal_immune_cell | 2.49167917 |
| 20 | MP0002452_abnormal_antigen_presenting | 2.47230682 |
| 21 | MP0002723_abnormal_immune_serum | 2.45074852 |
| 22 | MP0002148_abnormal_hypersensitivity_rea | 2.18064823 |
| 23 | MP0009840_abnormal_foam_cell | 2.15374835 |
| 24 | MP0003763_abnormal_thymus_physiology | 2.14305226 |
| 25 | MP0009278_abnormal_bone_marrow | 2.13717751 |
| 26 | MP0002398_abnormal_bone_marrow | 2.10319714 |
| 27 | MP0001851_eye_inflammation | 2.00898398 |
| 28 | MP0009333_abnormal_splenocyte_physiolog | 1.98357304 |
| 29 | MP0001533_abnormal_skeleton_physiology | 1.98085323 |
| 30 | MP0003300_gastrointestinal_ulcer | 1.97148535 |
| 31 | MP0000716_abnormal_immune_system | 1.95721367 |
| 32 | MP0002405_respiratory_system_inflammati | 1.87736647 |
| 33 | MP0008260_abnormal_autophagy | 1.86894458 |
| 34 | MP0002132_abnormal_respiratory_system | 1.85268830 |
| 35 | MP0002396_abnormal_hematopoietic_system | 1.74065355 |
| 36 | MP0005397_hematopoietic_system_phenotyp | 1.73711100 |
| 37 | MP0001545_abnormal_hematopoietic_system | 1.73711100 |
| 38 | MP0000689_abnormal_spleen_morphology | 1.72483926 |
| 39 | MP0001845_abnormal_inflammatory_respons | 1.70550755 |
| 40 | MP0002722_abnormal_immune_system | 1.62219299 |
| 41 | MP0009764_decreased_sensitivity_to | 1.61003390 |
| 42 | MP0005410_abnormal_fertilization | 1.59788673 |
| 43 | MP0002429_abnormal_blood_cell | 1.59304630 |
| 44 | MP0005076_abnormal_cell_differentiation | 1.50450819 |
| 45 | MP0005058_abnormal_lysosome_morphology | 1.46122926 |
| 46 | MP0000015_abnormal_ear_pigmentation | 1.43008833 |
| 47 | MP0006082_CNS_inflammation | 1.42555038 |
| 48 | MP0009697_abnormal_copulation | 1.41110832 |
| 49 | MP0003646_muscle_fatigue | 1.40500960 |
| 50 | MP0001853_heart_inflammation | 1.39480787 |
| 51 | MP0000703_abnormal_thymus_morphology | 1.39440457 |
| 52 | MP0008469_abnormal_protein_level | 1.39388010 |
| 53 | MP0002166_altered_tumor_susceptibility | 1.34674237 |
| 54 | MP0000604_amyloidosis | 1.33036787 |
| 55 | MP0000465_gastrointestinal_hemorrhage | 1.33021779 |
| 56 | MP0000858_altered_metastatic_potential | 1.24719709 |
| 57 | MP0010155_abnormal_intestine_physiology | 1.23417089 |
| 58 | MP0002933_joint_inflammation | 1.17278699 |
| 59 | MP0004947_skin_inflammation | 1.12972587 |
| 60 | MP0002332_abnormal_exercise_endurance | 1.08241105 |
| 61 | MP0004510_myositis | 1.06644844 |
| 62 | MP0003075_altered_response_to | 1.06483288 |
| 63 | MP0003183_abnormal_peptide_metabolism | 1.05804145 |
| 64 | MP0009763_increased_sensitivity_to | 1.04299900 |
| 65 | MP0003448_altered_tumor_morphology | 0.99633267 |
| 66 | MP0003329_amyloid_beta_deposits | 0.97000359 |
| 67 | MP0002998_abnormal_bone_remodeling | 0.95733383 |
| 68 | MP0005167_abnormal_blood-brain_barrier | 0.94207863 |
| 69 | MP0002006_tumorigenesis | 0.92327925 |
| 70 | MP0003866_abnormal_defecation | 0.90666774 |
| 71 | MP0004883_abnormal_blood_vessel | 0.90151456 |
| 72 | MP0005310_abnormal_salivary_gland | 0.87408093 |
| 73 | MP0003828_pulmonary_edema | 0.86417044 |
| 74 | MP0005535_abnormal_body_temperature | 0.85085398 |
| 75 | MP0000678_abnormal_parathyroid_gland | 0.84880120 |
| 76 | MP0004381_abnormal_hair_follicle | 0.84787306 |
| 77 | MP0002019_abnormal_tumor_incidence | 0.84737336 |
| 78 | MP0008874_decreased_physiological_sensi | 0.84601512 |
| 79 | MP0005645_abnormal_hypothalamus_physiol | 0.83566374 |
| 80 | MP0005166_decreased_susceptibility_to | 0.81498108 |
| 81 | MP0000249_abnormal_blood_vessel | 0.78887287 |
| 82 | MP0008004_abnormal_stomach_pH | 0.76970254 |
| 83 | MP0005319_abnormal_enzyme/_coenzyme | 0.76306166 |
| 84 | MP0005164_abnormal_response_to | 0.73643439 |
| 85 | MP0006036_abnormal_mitochondrial_physio | 0.72877467 |
| 86 | MP0004147_increased_porphyrin_level | 0.70283738 |
| 87 | MP0004808_abnormal_hematopoietic_stem | 0.69970895 |
| 88 | MP0006035_abnormal_mitochondrial_morpho | 0.69756070 |
| 89 | MP0005390_skeleton_phenotype | 0.68764003 |
| 90 | MP0000490_abnormal_crypts_of | 0.67469794 |
| 91 | MP0008961_abnormal_basal_metabolism | 0.64994800 |
| 92 | MP0001986_abnormal_taste_sensitivity | 0.63972623 |
| 93 | MP0005451_abnormal_body_composition | 0.63552966 |
| 94 | MP0000313_abnormal_cell_death | 0.63499408 |
| 95 | MP0001849_ear_inflammation | 0.63129914 |
| 96 | MP0003638_abnormal_response/metabolism_ | 0.61077911 |
| 97 | MP0009765_abnormal_xenobiotic_induced | 0.60732492 |
| 98 | MP0000681_abnormal_thyroid_gland | 0.58047438 |
| 99 | MP0001765_abnormal_ion_homeostasis | 0.55620186 |
| 100 | MP0001727_abnormal_embryo_implantation | 0.54220388 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Elevated erythrocyte sedimentation rate (HP:0003565) | 6.08301220 |
| 2 | Myositis (HP:0100614) | 5.17301005 |
| 3 | Spontaneous hematomas (HP:0007420) | 4.76888903 |
| 4 | Increased IgE level (HP:0003212) | 4.73952653 |
| 5 | Chronic obstructive pulmonary disease (HP:0006510) | 4.57079688 |
| 6 | Obstructive lung disease (HP:0006536) | 4.57079688 |
| 7 | Recurrent abscess formation (HP:0002722) | 4.53420263 |
| 8 | B lymphocytopenia (HP:0010976) | 4.05557267 |
| 9 | Recurrent bacterial skin infections (HP:0005406) | 4.00850919 |
| 10 | Abnormality of macrophages (HP:0004311) | 3.97846204 |
| 11 | Acute hepatic failure (HP:0006554) | 3.95451640 |
| 12 | Autoimmune hemolytic anemia (HP:0001890) | 3.89031728 |
| 13 | Eczematoid dermatitis (HP:0000976) | 3.88719553 |
| 14 | Abnormality of B cell number (HP:0010975) | 3.85900414 |
| 15 | Mediastinal lymphadenopathy (HP:0100721) | 3.85158262 |
| 16 | Thrombocytosis (HP:0001894) | 3.81853134 |
| 17 | Birth length less than 3rd percentile (HP:0003561) | 3.56700984 |
| 18 | Recurrent fungal infections (HP:0002841) | 3.53363801 |
| 19 | Meningitis (HP:0001287) | 3.49335100 |
| 20 | Stomatitis (HP:0010280) | 3.48089287 |
| 21 | Hypertensive crisis (HP:0100735) | 3.39991932 |
| 22 | Hypergammaglobulinemia (HP:0010702) | 3.37311540 |
| 23 | Retrobulbar optic neuritis (HP:0100654) | 3.36868981 |
| 24 | Optic neuritis (HP:0100653) | 3.36868981 |
| 25 | Autoimmune thrombocytopenia (HP:0001973) | 3.35726432 |
| 26 | Encephalitis (HP:0002383) | 3.26866096 |
| 27 | Orchitis (HP:0100796) | 3.23330588 |
| 28 | Granulocytopenia (HP:0001913) | 3.18938594 |
| 29 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.16692971 |
| 30 | Recurrent cutaneous fungal infections (HP:0011370) | 3.16692971 |
| 31 | Epistaxis (HP:0000421) | 3.14372874 |
| 32 | Recurrent viral infections (HP:0004429) | 3.10778567 |
| 33 | Prolonged bleeding time (HP:0003010) | 3.09538919 |
| 34 | Severe visual impairment (HP:0001141) | 3.06634746 |
| 35 | Keratoconjunctivitis sicca (HP:0001097) | 3.01135671 |
| 36 | Eosinophilia (HP:0001880) | 2.85900514 |
| 37 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.85248543 |
| 38 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.84268269 |
| 39 | Recurrent skin infections (HP:0001581) | 2.82944041 |
| 40 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.79024251 |
| 41 | Keratoconjunctivitis (HP:0001096) | 2.79008121 |
| 42 | Gastrointestinal infarctions (HP:0005244) | 2.78119078 |
| 43 | Severe combined immunodeficiency (HP:0004430) | 2.76720715 |
| 44 | Hemoptysis (HP:0002105) | 2.75674194 |
| 45 | Interstitial pulmonary disease (HP:0006530) | 2.69944933 |
| 46 | Panhypogammaglobulinemia (HP:0003139) | 2.69590298 |
| 47 | Gastrointestinal inflammation (HP:0004386) | 2.64808072 |
| 48 | Leukocytosis (HP:0001974) | 2.64505706 |
| 49 | Urticaria (HP:0001025) | 2.62912033 |
| 50 | Petechiae (HP:0000967) | 2.62308887 |
| 51 | Agammaglobulinemia (HP:0004432) | 2.51798307 |
| 52 | Purpura (HP:0000979) | 2.47546686 |
| 53 | Sepsis (HP:0100806) | 2.47138041 |
| 54 | Pulmonary infiltrates (HP:0002113) | 2.46085640 |
| 55 | Vasculitis (HP:0002633) | 2.45294961 |
| 56 | Mesangial abnormality (HP:0001966) | 2.44797985 |
| 57 | Increased IgM level (HP:0003496) | 2.44494339 |
| 58 | Chest pain (HP:0100749) | 2.40338366 |
| 59 | Abnormality of eosinophils (HP:0001879) | 2.38458490 |
| 60 | Pulmonary embolism (HP:0002204) | 2.36718745 |
| 61 | T lymphocytopenia (HP:0005403) | 2.29525695 |
| 62 | Combined immunodeficiency (HP:0005387) | 2.24432163 |
| 63 | Lymphopenia (HP:0001888) | 2.24181732 |
| 64 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.23747931 |
| 65 | Gingivitis (HP:0000230) | 2.18370998 |
| 66 | Aplastic anemia (HP:0001915) | 2.18051129 |
| 67 | Recurrent pneumonia (HP:0006532) | 2.16832660 |
| 68 | Arterial thrombosis (HP:0004420) | 2.14816552 |
| 69 | Abnormality of T cells (HP:0002843) | 2.13556207 |
| 70 | Inflammation of the large intestine (HP:0002037) | 2.13356260 |
| 71 | Abnormality of T cell number (HP:0011839) | 2.08376386 |
| 72 | Hyperthyroidism (HP:0000836) | 2.06919435 |
| 73 | Gingival bleeding (HP:0000225) | 2.05247712 |
| 74 | Thyroiditis (HP:0100646) | 2.05244430 |
| 75 | Increased cerebral lipofuscin (HP:0011813) | 2.03435952 |
| 76 | Abnormality of the thymus (HP:0000777) | 2.02654868 |
| 77 | Neonatal hypoglycemia (HP:0001998) | 2.02602162 |
| 78 | Recurrent lower respiratory tract infections (HP:0002783) | 2.01013542 |
| 79 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.00972297 |
| 80 | Truncus arteriosus (HP:0001660) | 2.00491046 |
| 81 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.00368995 |
| 82 | Microcytic anemia (HP:0001935) | 2.00321186 |
| 83 | Cellulitis (HP:0100658) | 2.00110881 |
| 84 | Colitis (HP:0002583) | 1.98426643 |
| 85 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.98318337 |
| 86 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.98318337 |
| 87 | Abnormality of glycolipid metabolism (HP:0010969) | 1.98318337 |
| 88 | Lymphoma (HP:0002665) | 1.95663722 |
| 89 | Conjunctival telangiectasia (HP:0000524) | 1.95169054 |
| 90 | Renal Fanconi syndrome (HP:0001994) | 1.95168922 |
| 91 | Hepatosplenomegaly (HP:0001433) | 1.94630121 |
| 92 | Episodic fever (HP:0001954) | 1.93281901 |
| 93 | Breast hypoplasia (HP:0003187) | 1.93207955 |
| 94 | Gastrointestinal dysmotility (HP:0002579) | 1.89587910 |
| 95 | Abnormal platelet volume (HP:0011876) | 1.89165722 |
| 96 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.85478604 |
| 97 | Thrombophlebitis (HP:0004418) | 1.85289335 |
| 98 | Abnormality of the fingertips (HP:0001211) | 1.83867181 |
| 99 | Seborrheic dermatitis (HP:0001051) | 1.81805320 |
| 100 | Keratitis (HP:0000491) | 1.81394873 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TESK2 | 4.70977010 |
| 2 | RIPK4 | 3.54929170 |
| 3 | TAOK3 | 3.38655755 |
| 4 | MAP4K1 | 3.18944229 |
| 5 | TBK1 | 3.14272977 |
| 6 | KDR | 2.84224374 |
| 7 | TESK1 | 2.46049866 |
| 8 | MAP2K3 | 2.32904140 |
| 9 | GRK6 | 2.27574147 |
| 10 | FES | 2.23538664 |
| 11 | BCKDK | 2.19077110 |
| 12 | KIT | 2.00766359 |
| 13 | TYK2 | 1.98094352 |
| 14 | BLK | 1.84552515 |
| 15 | CSF1R | 1.79807623 |
| 16 | BMX | 1.79211874 |
| 17 | TNK2 | 1.76429204 |
| 18 | SYK | 1.76162138 |
| 19 | PRPF4B | 1.74997268 |
| 20 | CSK | 1.72773379 |
| 21 | BTK | 1.71688067 |
| 22 | ZAP70 | 1.71550475 |
| 23 | JAK3 | 1.70240522 |
| 24 | ACVR1B | 1.69646167 |
| 25 | MAP3K11 | 1.58266769 |
| 26 | IRAK4 | 1.49637188 |
| 27 | IKBKB | 1.43728290 |
| 28 | BMPR1B | 1.37050187 |
| 29 | EPHB1 | 1.35227541 |
| 30 | MAP3K14 | 1.35186341 |
| 31 | PRKD2 | 1.35000705 |
| 32 | DAPK2 | 1.30228811 |
| 33 | HCK | 1.27195709 |
| 34 | TXK | 1.23886848 |
| 35 | LYN | 1.18179119 |
| 36 | LCK | 1.16522371 |
| 37 | TAOK1 | 1.16299540 |
| 38 | TRIB3 | 1.14681909 |
| 39 | STK10 | 1.14572831 |
| 40 | FGR | 1.13906088 |
| 41 | CAMKK1 | 1.10704341 |
| 42 | ERN1 | 1.07360192 |
| 43 | IKBKE | 1.06334555 |
| 44 | IRAK2 | 1.03347326 |
| 45 | MAP2K6 | 0.98505240 |
| 46 | TEC | 0.97429778 |
| 47 | SIK2 | 0.96451913 |
| 48 | SCYL2 | 0.90904841 |
| 49 | MARK2 | 0.90387399 |
| 50 | MAP3K7 | 0.89695614 |
| 51 | PIK3CG | 0.89031675 |
| 52 | JAK2 | 0.88844470 |
| 53 | BMPR2 | 0.86821266 |
| 54 | MATK | 0.84001448 |
| 55 | SIK3 | 0.80553768 |
| 56 | LRRK2 | 0.78255091 |
| 57 | ITK | 0.73438526 |
| 58 | CDK4 | 0.71695828 |
| 59 | DAPK1 | 0.70798550 |
| 60 | PTK2B | 0.68277971 |
| 61 | NEK9 | 0.67740152 |
| 62 | PDK1 | 0.67181465 |
| 63 | GRK7 | 0.63117094 |
| 64 | TAOK2 | 0.61422878 |
| 65 | MAP3K1 | 0.60920825 |
| 66 | FLT3 | 0.58196898 |
| 67 | PRKCH | 0.57126323 |
| 68 | KSR2 | 0.51644047 |
| 69 | DDR2 | 0.50474277 |
| 70 | PIM1 | 0.50110624 |
| 71 | DYRK1B | 0.49610314 |
| 72 | PBK | 0.49065811 |
| 73 | MAP3K13 | 0.48438199 |
| 74 | RPS6KA4 | 0.48265479 |
| 75 | FYN | 0.47448972 |
| 76 | JAK1 | 0.47159231 |
| 77 | MAP3K6 | 0.46796859 |
| 78 | CAMK4 | 0.46792086 |
| 79 | CDK7 | 0.45152383 |
| 80 | STK38 | 0.43591003 |
| 81 | AURKA | 0.43225067 |
| 82 | MAP3K12 | 0.41802161 |
| 83 | PRKCQ | 0.41042782 |
| 84 | PRKG2 | 0.39477024 |
| 85 | MAP3K3 | 0.38702968 |
| 86 | MARK3 | 0.38180288 |
| 87 | CAMK1 | 0.38044667 |
| 88 | PDPK1 | 0.37698609 |
| 89 | CLK1 | 0.37043553 |
| 90 | PTK6 | 0.36473504 |
| 91 | TGFBR1 | 0.34626966 |
| 92 | NUAK1 | 0.33846250 |
| 93 | PRKCD | 0.33596960 |
| 94 | PAK1 | 0.32274747 |
| 95 | IRAK1 | 0.32127458 |
| 96 | CDK6 | 0.30501271 |
| 97 | PRKAA2 | 0.30035407 |
| 98 | PRKD1 | 0.29792031 |
| 99 | SMG1 | 0.28035060 |
| 100 | MAPK3 | 0.27600238 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.44472546 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 2.75419109 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.57066850 |
| 4 | Allograft rejection_Homo sapiens_hsa05330 | 2.55313731 |
| 5 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.42098653 |
| 6 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.42036720 |
| 7 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.39452801 |
| 8 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.35586313 |
| 9 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.33770239 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.33044038 |
| 11 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.16414394 |
| 12 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 2.16147715 |
| 13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.10728368 |
| 14 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.10576855 |
| 15 | Tuberculosis_Homo sapiens_hsa05152 | 2.04893428 |
| 16 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.94313624 |
| 17 | Shigellosis_Homo sapiens_hsa05131 | 1.88200589 |
| 18 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.78606181 |
| 19 | Asthma_Homo sapiens_hsa05310 | 1.75058001 |
| 20 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.71334512 |
| 21 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.71234066 |
| 22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.68229246 |
| 23 | Measles_Homo sapiens_hsa05162 | 1.67913789 |
| 24 | Viral myocarditis_Homo sapiens_hsa05416 | 1.62735441 |
| 25 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.57669682 |
| 26 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.56850172 |
| 27 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.53745087 |
| 28 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.53735002 |
| 29 | Platelet activation_Homo sapiens_hsa04611 | 1.52606058 |
| 30 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.51160376 |
| 31 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.49704569 |
| 32 | Influenza A_Homo sapiens_hsa05164 | 1.47035374 |
| 33 | Malaria_Homo sapiens_hsa05144 | 1.46841350 |
| 34 | Salmonella infection_Homo sapiens_hsa05132 | 1.46837066 |
| 35 | Phagosome_Homo sapiens_hsa04145 | 1.41316679 |
| 36 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.36893092 |
| 37 | Lysosome_Homo sapiens_hsa04142 | 1.34630644 |
| 38 | Legionellosis_Homo sapiens_hsa05134 | 1.31853572 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.26858495 |
| 40 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.26687615 |
| 41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.21091619 |
| 42 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.20765721 |
| 43 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.20439464 |
| 44 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.16908909 |
| 45 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.12605012 |
| 46 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.10450541 |
| 47 | Pertussis_Homo sapiens_hsa05133 | 1.08514398 |
| 48 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.04036336 |
| 49 | Hepatitis B_Homo sapiens_hsa05161 | 1.03810713 |
| 50 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.01766039 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.01094556 |
| 52 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.00341578 |
| 53 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.94266057 |
| 54 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.93386016 |
| 55 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.89428990 |
| 56 | Other glycan degradation_Homo sapiens_hsa00511 | 0.88523969 |
| 57 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.86589923 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.86253207 |
| 59 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.86016508 |
| 60 | Endocytosis_Homo sapiens_hsa04144 | 0.85779628 |
| 61 | Alcoholism_Homo sapiens_hsa05034 | 0.83892276 |
| 62 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.83614835 |
| 63 | Apoptosis_Homo sapiens_hsa04210 | 0.81263243 |
| 64 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.71370683 |
| 65 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.69397555 |
| 66 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.69174759 |
| 67 | DNA replication_Homo sapiens_hsa03030 | 0.67903855 |
| 68 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.58197420 |
| 69 | Base excision repair_Homo sapiens_hsa03410 | 0.57388323 |
| 70 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.56419666 |
| 71 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.56075659 |
| 72 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.55728716 |
| 73 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.50701876 |
| 74 | Bladder cancer_Homo sapiens_hsa05219 | 0.50619227 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49916413 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.49656982 |
| 77 | Hepatitis C_Homo sapiens_hsa05160 | 0.48471699 |
| 78 | HTLV-I infection_Homo sapiens_hsa05166 | 0.48432747 |
| 79 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.47177179 |
| 80 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.46561819 |
| 81 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.44227995 |
| 82 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.43959930 |
| 83 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.40185294 |
| 84 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.37183558 |
| 85 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36281955 |
| 86 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.35632722 |
| 87 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.35467701 |
| 88 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.31930324 |
| 89 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.28876828 |
| 90 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.27735316 |
| 91 | Amoebiasis_Homo sapiens_hsa05146 | 0.27510519 |
| 92 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26660633 |
| 93 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.26118396 |
| 94 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.25749654 |
| 95 | Insulin resistance_Homo sapiens_hsa04931 | 0.25110996 |
| 96 | ABC transporters_Homo sapiens_hsa02010 | 0.22991370 |
| 97 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.21757120 |
| 98 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.16347963 |
| 99 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.14928866 |
| 100 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.12831079 |

