CNN2P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.50794758
2purine deoxyribonucleotide catabolic process (GO:0009155)5.43088231
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.39287527
4regulation of B cell receptor signaling pathway (GO:0050855)5.32580761
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.25347092
6antigen processing and presentation of endogenous antigen (GO:0019883)5.20820838
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.18890901
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15473593
9Arp2/3 complex-mediated actin nucleation (GO:0034314)5.10019767
10positive regulation of gamma-delta T cell activation (GO:0046645)4.97351293
11antigen processing and presentation via MHC class Ib (GO:0002475)4.68767779
12positive regulation of B cell differentiation (GO:0045579)4.63559855
13response to peptidoglycan (GO:0032494)4.56524379
14negative regulation of phagocytosis (GO:0050765)4.51581683
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.46718221
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.46718221
17modulation by symbiont of host immune response (GO:0052553)4.46718221
18positive regulation by symbiont of host defense response (GO:0052509)4.46718221
19modulation by symbiont of host defense response (GO:0052031)4.46718221
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.46718221
21cytidine metabolic process (GO:0046087)4.26932607
22cytidine catabolic process (GO:0006216)4.26932607
23cytidine deamination (GO:0009972)4.26932607
24neutrophil activation involved in immune response (GO:0002283)4.15322234
25response to host immune response (GO:0052572)4.13568574
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.13568574
27histamine secretion (GO:0001821)4.06876698
28positive regulation of mast cell activation (GO:0033005)4.04942328
29actin nucleation (GO:0045010)4.00573855
30regulation of mast cell degranulation (GO:0043304)3.98336037
31autophagic vacuole fusion (GO:0000046)3.95946557
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87408677
33negative regulation of cell killing (GO:0031342)3.87408677
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.86167987
35DNA deamination (GO:0045006)3.80451746
36B cell receptor signaling pathway (GO:0050853)3.77278923
37cellular extravasation (GO:0045123)3.76765886
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.76631046
39positive regulation of mast cell degranulation (GO:0043306)3.76631046
40neutrophil mediated immunity (GO:0002446)3.71867920
41regulation of B cell differentiation (GO:0045577)3.68792466
42regulation of mast cell activation involved in immune response (GO:0033006)3.67691179
43positive regulation of antigen processing and presentation (GO:0002579)3.66213463
44response to host (GO:0075136)3.62432196
45response to host defenses (GO:0052200)3.62432196
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62432196
47immunoglobulin mediated immune response (GO:0016064)3.57392924
48regulation of gamma-delta T cell activation (GO:0046643)3.54566862
49regulation of antigen processing and presentation (GO:0002577)3.53393512
50respiratory burst (GO:0045730)3.53322575
51macrophage activation involved in immune response (GO:0002281)3.52927117
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43213067
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42359549
54negative regulation of interleukin-12 production (GO:0032695)3.41670832
55response to pheromone (GO:0019236)3.39980779
56deoxyribonucleotide catabolic process (GO:0009264)3.36333166
57negative regulation of B cell apoptotic process (GO:0002903)3.35928683
58regulation of gamma-delta T cell differentiation (GO:0045586)3.35225926
59regulation of leukocyte degranulation (GO:0043300)3.35131626
60response to muramyl dipeptide (GO:0032495)3.34976410
61regulation of mast cell activation (GO:0033003)3.34186767
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26778912
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25786884
64deoxyribose phosphate catabolic process (GO:0046386)3.25687891
65regulation of germinal center formation (GO:0002634)3.19182830
66deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.17840733
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.17172852
68regulation of interferon-beta biosynthetic process (GO:0045357)3.15878515
69regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15747804
70Peyers patch development (GO:0048541)3.14167328
71mucosal-associated lymphoid tissue development (GO:0048537)3.14167328
72positive regulation of natural killer cell differentiation (GO:0032825)3.13811480
73regulation of B cell apoptotic process (GO:0002902)3.13758760
74cellular response to exogenous dsRNA (GO:0071360)3.11499546
75mature B cell differentiation involved in immune response (GO:0002313)3.09808384
76neutrophil activation (GO:0042119)3.09746668
77detection of other organism (GO:0098543)3.08457742
78detection of molecule of bacterial origin (GO:0032490)3.07679149
79negative regulation of leukocyte mediated immunity (GO:0002704)3.04850162
80negative regulation of telomere maintenance (GO:0032205)3.04783347
81organelle membrane fusion (GO:0090174)3.01993439
82histamine transport (GO:0051608)2.98802878
83negative regulation of interleukin-6 production (GO:0032715)2.97968971
84regulation of interleukin-6 biosynthetic process (GO:0045408)2.97827329
85detection of bacterium (GO:0016045)2.92605352
86microglial cell activation (GO:0001774)2.92037351
87disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.91737253
88killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.91737253
89myeloid leukocyte mediated immunity (GO:0002444)2.91672034
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.91479868
91leukocyte aggregation (GO:0070486)2.90509569
92response to interferon-beta (GO:0035456)2.89673120
93detection of external biotic stimulus (GO:0098581)2.88004589
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.87968321
95regulation of telomere maintenance via telomerase (GO:0032210)2.87897137
96myeloid cell activation involved in immune response (GO:0002275)2.86385872
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83325915
98negative regulation of interleukin-1 beta production (GO:0032691)2.83185725
99regulation of regulated secretory pathway (GO:1903305)2.82300511
100type I interferon signaling pathway (GO:0060337)2.82283143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.97156463
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.51974192
3VDR_21846776_ChIP-Seq_THP-1_Human3.41364499
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.26334128
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09492832
6SCL_19346495_ChIP-Seq_HPC-7_Human2.92795656
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89597140
8VDR_24763502_ChIP-Seq_THP-1_Human2.89408267
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77375884
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76608519
11SPI1_23547873_ChIP-Seq_NB4_Human2.57703752
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57041857
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46409627
14UTX_26944678_Chip-Seq_JUKART_Human2.45006079
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42130672
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36695211
17SPI1_23127762_ChIP-Seq_K562_Human2.34587446
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34116586
19MYB_26560356_Chip-Seq_TH2_Human2.33296024
20MAF_26560356_Chip-Seq_TH1_Human2.29635265
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.28312534
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27855935
23MYC_22102868_ChIP-Seq_BL_Human2.26939140
24RUNX_20019798_ChIP-Seq_JUKART_Human2.26834265
25GATA1_22025678_ChIP-Seq_K562_Human2.21161564
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17866063
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11622626
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10871771
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09696538
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.03715485
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.01718798
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.01370151
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01178580
34MYB_26560356_Chip-Seq_TH1_Human1.99878036
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89356739
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86344812
37CIITA_25753668_ChIP-Seq_RAJI_Human1.83259791
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82857346
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81536189
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80638607
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79981027
42TCF7_22412390_ChIP-Seq_EML_Mouse1.77042834
43BCL6_27268052_Chip-Seq_Bcells_Human1.76662565
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71930888
45LXR_22292898_ChIP-Seq_THP-1_Human1.70403527
46GATA3_27048872_Chip-Seq_THYMUS_Human1.65964727
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.65797834
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62653543
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62478958
50MAF_26560356_Chip-Seq_TH2_Human1.60918329
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60914646
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.60370460
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54925845
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.51467312
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49464761
56KDM2B_26808549_Chip-Seq_DND41_Human1.47404580
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47053999
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43105676
59BCOR_27268052_Chip-Seq_Bcells_Human1.41903222
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41509387
61VDR_24787735_ChIP-Seq_THP-1_Human1.41066284
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39891930
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35565698
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32816047
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32161077
66GATA1_19941826_ChIP-Seq_K562_Human1.28793178
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27504052
68SPI1_20517297_ChIP-Seq_HL60_Human1.26580704
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26580082
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25874883
71GATA3_26560356_Chip-Seq_TH2_Human1.25098110
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24948227
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24714924
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24339223
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21586031
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20133892
77NCOR1_26117541_ChIP-Seq_K562_Human1.17997007
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16142280
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.16104251
80E2F1_20622854_ChIP-Seq_HELA_Human1.15218894
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14928801
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14846964
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13780202
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13690205
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13120990
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11446158
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10796338
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10441949
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09206371
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07560645
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07262525
92P68_20966046_ChIP-Seq_HELA_Human1.07198142
93P300_27268052_Chip-Seq_Bcells_Human1.05125250
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03629496
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.02199244
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01360261
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00492616
98PU_27001747_Chip-Seq_BMDM_Mouse0.99732455
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99617049
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99004757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.67685197
2MP0003436_decreased_susceptibility_to3.49866637
3MP0005671_abnormal_response_to3.34839073
4MP0003724_increased_susceptibility_to3.27881681
5MP0009785_altered_susceptibility_to3.09054756
6MP0005025_abnormal_response_to2.95438693
7MP0003303_peritoneal_inflammation2.92944805
8MP0002419_abnormal_innate_immunity2.91255092
9MP0003172_abnormal_lysosome_physiology2.78901819
10MP0005000_abnormal_immune_tolerance2.78757272
11MP0001800_abnormal_humoral_immune2.73117472
12MP0005464_abnormal_platelet_physiology2.63162629
13MP0001348_abnormal_lacrimal_gland2.60740905
14MP0000685_abnormal_immune_system2.60735457
15MP0003191_abnormal_cellular_cholesterol2.60406897
16MP0002420_abnormal_adaptive_immunity2.57424739
17MP0005387_immune_system_phenotype2.57057739
18MP0001790_abnormal_immune_system2.57057739
19MP0001819_abnormal_immune_cell2.49167917
20MP0002452_abnormal_antigen_presenting2.47230682
21MP0002723_abnormal_immune_serum2.45074852
22MP0002148_abnormal_hypersensitivity_rea2.18064823
23MP0009840_abnormal_foam_cell2.15374835
24MP0003763_abnormal_thymus_physiology2.14305226
25MP0009278_abnormal_bone_marrow2.13717751
26MP0002398_abnormal_bone_marrow2.10319714
27MP0001851_eye_inflammation2.00898398
28MP0009333_abnormal_splenocyte_physiolog1.98357304
29MP0001533_abnormal_skeleton_physiology1.98085323
30MP0003300_gastrointestinal_ulcer1.97148535
31MP0000716_abnormal_immune_system1.95721367
32MP0002405_respiratory_system_inflammati1.87736647
33MP0008260_abnormal_autophagy1.86894458
34MP0002132_abnormal_respiratory_system1.85268830
35MP0002396_abnormal_hematopoietic_system1.74065355
36MP0005397_hematopoietic_system_phenotyp1.73711100
37MP0001545_abnormal_hematopoietic_system1.73711100
38MP0000689_abnormal_spleen_morphology1.72483926
39MP0001845_abnormal_inflammatory_respons1.70550755
40MP0002722_abnormal_immune_system1.62219299
41MP0009764_decreased_sensitivity_to1.61003390
42MP0005410_abnormal_fertilization1.59788673
43MP0002429_abnormal_blood_cell1.59304630
44MP0005076_abnormal_cell_differentiation1.50450819
45MP0005058_abnormal_lysosome_morphology1.46122926
46MP0000015_abnormal_ear_pigmentation1.43008833
47MP0006082_CNS_inflammation1.42555038
48MP0009697_abnormal_copulation1.41110832
49MP0003646_muscle_fatigue1.40500960
50MP0001853_heart_inflammation1.39480787
51MP0000703_abnormal_thymus_morphology1.39440457
52MP0008469_abnormal_protein_level1.39388010
53MP0002166_altered_tumor_susceptibility1.34674237
54MP0000604_amyloidosis1.33036787
55MP0000465_gastrointestinal_hemorrhage1.33021779
56MP0000858_altered_metastatic_potential1.24719709
57MP0010155_abnormal_intestine_physiology1.23417089
58MP0002933_joint_inflammation1.17278699
59MP0004947_skin_inflammation1.12972587
60MP0002332_abnormal_exercise_endurance1.08241105
61MP0004510_myositis1.06644844
62MP0003075_altered_response_to1.06483288
63MP0003183_abnormal_peptide_metabolism1.05804145
64MP0009763_increased_sensitivity_to1.04299900
65MP0003448_altered_tumor_morphology0.99633267
66MP0003329_amyloid_beta_deposits0.97000359
67MP0002998_abnormal_bone_remodeling0.95733383
68MP0005167_abnormal_blood-brain_barrier0.94207863
69MP0002006_tumorigenesis0.92327925
70MP0003866_abnormal_defecation0.90666774
71MP0004883_abnormal_blood_vessel0.90151456
72MP0005310_abnormal_salivary_gland0.87408093
73MP0003828_pulmonary_edema0.86417044
74MP0005535_abnormal_body_temperature0.85085398
75MP0000678_abnormal_parathyroid_gland0.84880120
76MP0004381_abnormal_hair_follicle0.84787306
77MP0002019_abnormal_tumor_incidence0.84737336
78MP0008874_decreased_physiological_sensi0.84601512
79MP0005645_abnormal_hypothalamus_physiol0.83566374
80MP0005166_decreased_susceptibility_to0.81498108
81MP0000249_abnormal_blood_vessel0.78887287
82MP0008004_abnormal_stomach_pH0.76970254
83MP0005319_abnormal_enzyme/_coenzyme0.76306166
84MP0005164_abnormal_response_to0.73643439
85MP0006036_abnormal_mitochondrial_physio0.72877467
86MP0004147_increased_porphyrin_level0.70283738
87MP0004808_abnormal_hematopoietic_stem0.69970895
88MP0006035_abnormal_mitochondrial_morpho0.69756070
89MP0005390_skeleton_phenotype0.68764003
90MP0000490_abnormal_crypts_of0.67469794
91MP0008961_abnormal_basal_metabolism0.64994800
92MP0001986_abnormal_taste_sensitivity0.63972623
93MP0005451_abnormal_body_composition0.63552966
94MP0000313_abnormal_cell_death0.63499408
95MP0001849_ear_inflammation0.63129914
96MP0003638_abnormal_response/metabolism_0.61077911
97MP0009765_abnormal_xenobiotic_induced0.60732492
98MP0000681_abnormal_thyroid_gland0.58047438
99MP0001765_abnormal_ion_homeostasis0.55620186
100MP0001727_abnormal_embryo_implantation0.54220388

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.08301220
2Myositis (HP:0100614)5.17301005
3Spontaneous hematomas (HP:0007420)4.76888903
4Increased IgE level (HP:0003212)4.73952653
5Chronic obstructive pulmonary disease (HP:0006510)4.57079688
6Obstructive lung disease (HP:0006536)4.57079688
7Recurrent abscess formation (HP:0002722)4.53420263
8B lymphocytopenia (HP:0010976)4.05557267
9Recurrent bacterial skin infections (HP:0005406)4.00850919
10Abnormality of macrophages (HP:0004311)3.97846204
11Acute hepatic failure (HP:0006554)3.95451640
12Autoimmune hemolytic anemia (HP:0001890)3.89031728
13Eczematoid dermatitis (HP:0000976)3.88719553
14Abnormality of B cell number (HP:0010975)3.85900414
15Mediastinal lymphadenopathy (HP:0100721)3.85158262
16Thrombocytosis (HP:0001894)3.81853134
17Birth length less than 3rd percentile (HP:0003561)3.56700984
18Recurrent fungal infections (HP:0002841)3.53363801
19Meningitis (HP:0001287)3.49335100
20Stomatitis (HP:0010280)3.48089287
21Hypertensive crisis (HP:0100735)3.39991932
22Hypergammaglobulinemia (HP:0010702)3.37311540
23Retrobulbar optic neuritis (HP:0100654)3.36868981
24Optic neuritis (HP:0100653)3.36868981
25Autoimmune thrombocytopenia (HP:0001973)3.35726432
26Encephalitis (HP:0002383)3.26866096
27Orchitis (HP:0100796)3.23330588
28Granulocytopenia (HP:0001913)3.18938594
29Chronic mucocutaneous candidiasis (HP:0002728)3.16692971
30Recurrent cutaneous fungal infections (HP:0011370)3.16692971
31Epistaxis (HP:0000421)3.14372874
32Recurrent viral infections (HP:0004429)3.10778567
33Prolonged bleeding time (HP:0003010)3.09538919
34Severe visual impairment (HP:0001141)3.06634746
35Keratoconjunctivitis sicca (HP:0001097)3.01135671
36Eosinophilia (HP:0001880)2.85900514
37Aplasia/Hypoplasia of the thymus (HP:0010515)2.85248543
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.84268269
39Recurrent skin infections (HP:0001581)2.82944041
40Recurrent gram-negative bacterial infections (HP:0005420)2.79024251
41Keratoconjunctivitis (HP:0001096)2.79008121
42Gastrointestinal infarctions (HP:0005244)2.78119078
43Severe combined immunodeficiency (HP:0004430)2.76720715
44Hemoptysis (HP:0002105)2.75674194
45Interstitial pulmonary disease (HP:0006530)2.69944933
46Panhypogammaglobulinemia (HP:0003139)2.69590298
47Gastrointestinal inflammation (HP:0004386)2.64808072
48Leukocytosis (HP:0001974)2.64505706
49Urticaria (HP:0001025)2.62912033
50Petechiae (HP:0000967)2.62308887
51Agammaglobulinemia (HP:0004432)2.51798307
52Purpura (HP:0000979)2.47546686
53Sepsis (HP:0100806)2.47138041
54Pulmonary infiltrates (HP:0002113)2.46085640
55Vasculitis (HP:0002633)2.45294961
56Mesangial abnormality (HP:0001966)2.44797985
57Increased IgM level (HP:0003496)2.44494339
58Chest pain (HP:0100749)2.40338366
59Abnormality of eosinophils (HP:0001879)2.38458490
60Pulmonary embolism (HP:0002204)2.36718745
61T lymphocytopenia (HP:0005403)2.29525695
62Combined immunodeficiency (HP:0005387)2.24432163
63Lymphopenia (HP:0001888)2.24181732
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23747931
65Gingivitis (HP:0000230)2.18370998
66Aplastic anemia (HP:0001915)2.18051129
67Recurrent pneumonia (HP:0006532)2.16832660
68Arterial thrombosis (HP:0004420)2.14816552
69Abnormality of T cells (HP:0002843)2.13556207
70Inflammation of the large intestine (HP:0002037)2.13356260
71Abnormality of T cell number (HP:0011839)2.08376386
72Hyperthyroidism (HP:0000836)2.06919435
73Gingival bleeding (HP:0000225)2.05247712
74Thyroiditis (HP:0100646)2.05244430
75Increased cerebral lipofuscin (HP:0011813)2.03435952
76Abnormality of the thymus (HP:0000777)2.02654868
77Neonatal hypoglycemia (HP:0001998)2.02602162
78Recurrent lower respiratory tract infections (HP:0002783)2.01013542
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00972297
80Truncus arteriosus (HP:0001660)2.00491046
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.00368995
82Microcytic anemia (HP:0001935)2.00321186
83Cellulitis (HP:0100658)2.00110881
84Colitis (HP:0002583)1.98426643
85Abnormality of liposaccharide metabolism (HP:0010968)1.98318337
86Abnormality of glycosphingolipid metabolism (HP:0004343)1.98318337
87Abnormality of glycolipid metabolism (HP:0010969)1.98318337
88Lymphoma (HP:0002665)1.95663722
89Conjunctival telangiectasia (HP:0000524)1.95169054
90Renal Fanconi syndrome (HP:0001994)1.95168922
91Hepatosplenomegaly (HP:0001433)1.94630121
92Episodic fever (HP:0001954)1.93281901
93Breast hypoplasia (HP:0003187)1.93207955
94Gastrointestinal dysmotility (HP:0002579)1.89587910
95Abnormal platelet volume (HP:0011876)1.89165722
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.85478604
97Thrombophlebitis (HP:0004418)1.85289335
98Abnormality of the fingertips (HP:0001211)1.83867181
99Seborrheic dermatitis (HP:0001051)1.81805320
100Keratitis (HP:0000491)1.81394873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.70977010
2RIPK43.54929170
3TAOK33.38655755
4MAP4K13.18944229
5TBK13.14272977
6KDR2.84224374
7TESK12.46049866
8MAP2K32.32904140
9GRK62.27574147
10FES2.23538664
11BCKDK2.19077110
12KIT2.00766359
13TYK21.98094352
14BLK1.84552515
15CSF1R1.79807623
16BMX1.79211874
17TNK21.76429204
18SYK1.76162138
19PRPF4B1.74997268
20CSK1.72773379
21BTK1.71688067
22ZAP701.71550475
23JAK31.70240522
24ACVR1B1.69646167
25MAP3K111.58266769
26IRAK41.49637188
27IKBKB1.43728290
28BMPR1B1.37050187
29EPHB11.35227541
30MAP3K141.35186341
31PRKD21.35000705
32DAPK21.30228811
33HCK1.27195709
34TXK1.23886848
35LYN1.18179119
36LCK1.16522371
37TAOK11.16299540
38TRIB31.14681909
39STK101.14572831
40FGR1.13906088
41CAMKK11.10704341
42ERN11.07360192
43IKBKE1.06334555
44IRAK21.03347326
45MAP2K60.98505240
46TEC0.97429778
47SIK20.96451913
48SCYL20.90904841
49MARK20.90387399
50MAP3K70.89695614
51PIK3CG0.89031675
52JAK20.88844470
53BMPR20.86821266
54MATK0.84001448
55SIK30.80553768
56LRRK20.78255091
57ITK0.73438526
58CDK40.71695828
59DAPK10.70798550
60PTK2B0.68277971
61NEK90.67740152
62PDK10.67181465
63GRK70.63117094
64TAOK20.61422878
65MAP3K10.60920825
66FLT30.58196898
67PRKCH0.57126323
68KSR20.51644047
69DDR20.50474277
70PIM10.50110624
71DYRK1B0.49610314
72PBK0.49065811
73MAP3K130.48438199
74RPS6KA40.48265479
75FYN0.47448972
76JAK10.47159231
77MAP3K60.46796859
78CAMK40.46792086
79CDK70.45152383
80STK380.43591003
81AURKA0.43225067
82MAP3K120.41802161
83PRKCQ0.41042782
84PRKG20.39477024
85MAP3K30.38702968
86MARK30.38180288
87CAMK10.38044667
88PDPK10.37698609
89CLK10.37043553
90PTK60.36473504
91TGFBR10.34626966
92NUAK10.33846250
93PRKCD0.33596960
94PAK10.32274747
95IRAK10.32127458
96CDK60.30501271
97PRKAA20.30035407
98PRKD10.29792031
99SMG10.28035060
100MAPK30.27600238

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.44472546
2Leishmaniasis_Homo sapiens_hsa051402.75419109
3Graft-versus-host disease_Homo sapiens_hsa053322.57066850
4Allograft rejection_Homo sapiens_hsa053302.55313731
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.42098653
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.42036720
7Autoimmune thyroid disease_Homo sapiens_hsa053202.39452801
8B cell receptor signaling pathway_Homo sapiens_hsa046622.35586313
9Osteoclast differentiation_Homo sapiens_hsa043802.33770239
10Hematopoietic cell lineage_Homo sapiens_hsa046402.33044038
11Staphylococcus aureus infection_Homo sapiens_hsa051502.16414394
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.16147715
13Antigen processing and presentation_Homo sapiens_hsa046122.10728368
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10576855
15Tuberculosis_Homo sapiens_hsa051522.04893428
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94313624
17Shigellosis_Homo sapiens_hsa051311.88200589
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78606181
19Asthma_Homo sapiens_hsa053101.75058001
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.71334512
21Type I diabetes mellitus_Homo sapiens_hsa049401.71234066
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68229246
23Measles_Homo sapiens_hsa051621.67913789
24Viral myocarditis_Homo sapiens_hsa054161.62735441
25Acute myeloid leukemia_Homo sapiens_hsa052211.57669682
26T cell receptor signaling pathway_Homo sapiens_hsa046601.56850172
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53745087
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53735002
29Platelet activation_Homo sapiens_hsa046111.52606058
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51160376
31Herpes simplex infection_Homo sapiens_hsa051681.49704569
32Influenza A_Homo sapiens_hsa051641.47035374
33Malaria_Homo sapiens_hsa051441.46841350
34Salmonella infection_Homo sapiens_hsa051321.46837066
35Phagosome_Homo sapiens_hsa041451.41316679
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.36893092
37Lysosome_Homo sapiens_hsa041421.34630644
38Legionellosis_Homo sapiens_hsa051341.31853572
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26858495
40Systemic lupus erythematosus_Homo sapiens_hsa053221.26687615
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.21091619
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20765721
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.20439464
44Chemokine signaling pathway_Homo sapiens_hsa040621.16908909
45Toxoplasmosis_Homo sapiens_hsa051451.12605012
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10450541
47Pertussis_Homo sapiens_hsa051331.08514398
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.04036336
49Hepatitis B_Homo sapiens_hsa051611.03810713
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01766039
51Viral carcinogenesis_Homo sapiens_hsa052031.01094556
52Rheumatoid arthritis_Homo sapiens_hsa053231.00341578
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94266057
54TNF signaling pathway_Homo sapiens_hsa046680.93386016
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89428990
56Other glycan degradation_Homo sapiens_hsa005110.88523969
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86589923
58Epstein-Barr virus infection_Homo sapiens_hsa051690.86253207
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86016508
60Endocytosis_Homo sapiens_hsa041440.85779628
61Alcoholism_Homo sapiens_hsa050340.83892276
62African trypanosomiasis_Homo sapiens_hsa051430.83614835
63Apoptosis_Homo sapiens_hsa042100.81263243
64Non-small cell lung cancer_Homo sapiens_hsa052230.71370683
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69397555
66Pentose phosphate pathway_Homo sapiens_hsa000300.69174759
67DNA replication_Homo sapiens_hsa030300.67903855
68VEGF signaling pathway_Homo sapiens_hsa043700.58197420
69Base excision repair_Homo sapiens_hsa034100.57388323
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56419666
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.56075659
72Pancreatic cancer_Homo sapiens_hsa052120.55728716
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.50701876
74Bladder cancer_Homo sapiens_hsa052190.50619227
75Regulation of autophagy_Homo sapiens_hsa041400.49916413
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49656982
77Hepatitis C_Homo sapiens_hsa051600.48471699
78HTLV-I infection_Homo sapiens_hsa051660.48432747
79Inositol phosphate metabolism_Homo sapiens_hsa005620.47177179
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46561819
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44227995
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.43959930
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40185294
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37183558
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36281955
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35632722
87Prolactin signaling pathway_Homo sapiens_hsa049170.35467701
88HIF-1 signaling pathway_Homo sapiens_hsa040660.31930324
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28876828
90Chronic myeloid leukemia_Homo sapiens_hsa052200.27735316
91Amoebiasis_Homo sapiens_hsa051460.27510519
92Olfactory transduction_Homo sapiens_hsa047400.26660633
93Renin-angiotensin system_Homo sapiens_hsa046140.26118396
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.25749654
95Insulin resistance_Homo sapiens_hsa049310.25110996
96ABC transporters_Homo sapiens_hsa020100.22991370
97Tyrosine metabolism_Homo sapiens_hsa003500.21757120
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16347963
99Notch signaling pathway_Homo sapiens_hsa043300.14928866
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.12831079

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