

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.40046335 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.89711739 |
| 3 | synaptic vesicle maturation (GO:0016188) | 5.87913274 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.77152882 |
| 5 | synaptic vesicle exocytosis (GO:0016079) | 5.54800302 |
| 6 | vocalization behavior (GO:0071625) | 5.47685120 |
| 7 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.43581236 |
| 8 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.32590416 |
| 9 | glutamate secretion (GO:0014047) | 5.28403049 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.21657865 |
| 11 | neuronal action potential propagation (GO:0019227) | 5.17472763 |
| 12 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.99410814 |
| 13 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.95802447 |
| 14 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.91860831 |
| 15 | glutamate receptor signaling pathway (GO:0007215) | 4.82214114 |
| 16 | neurotransmitter secretion (GO:0007269) | 4.78622216 |
| 17 | synaptic transmission, glutamatergic (GO:0035249) | 4.74113896 |
| 18 | protein localization to synapse (GO:0035418) | 4.73066004 |
| 19 | regulation of synaptic vesicle transport (GO:1902803) | 4.57295304 |
| 20 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.56994740 |
| 21 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.53953593 |
| 22 | gamma-aminobutyric acid transport (GO:0015812) | 4.52061767 |
| 23 | exploration behavior (GO:0035640) | 4.45892554 |
| 24 | neuron-neuron synaptic transmission (GO:0007270) | 4.42757150 |
| 25 | cellular potassium ion homeostasis (GO:0030007) | 4.28738407 |
| 26 | long-term memory (GO:0007616) | 4.26904592 |
| 27 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.22817581 |
| 28 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.21213422 |
| 29 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.17223628 |
| 30 | negative regulation of dendrite morphogenesis (GO:0050774) | 4.15863163 |
| 31 | neuron cell-cell adhesion (GO:0007158) | 4.11912473 |
| 32 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.10163197 |
| 33 | regulation of synapse structural plasticity (GO:0051823) | 4.02758027 |
| 34 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.02547319 |
| 35 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.96895564 |
| 36 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.93574094 |
| 37 | neurotransmitter transport (GO:0006836) | 3.92826392 |
| 38 | positive regulation of synapse maturation (GO:0090129) | 3.90273997 |
| 39 | positive regulation of membrane potential (GO:0045838) | 3.88778678 |
| 40 | regulation of postsynaptic membrane potential (GO:0060078) | 3.87207540 |
| 41 | sodium ion export (GO:0071436) | 3.85811009 |
| 42 | neuromuscular process controlling posture (GO:0050884) | 3.82603006 |
| 43 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.81533398 |
| 44 | regulation of synaptic plasticity (GO:0048167) | 3.76824258 |
| 45 | proline transport (GO:0015824) | 3.68865077 |
| 46 | transmission of nerve impulse (GO:0019226) | 3.67776254 |
| 47 | regulation of neurotransmitter levels (GO:0001505) | 3.67229851 |
| 48 | dendritic spine morphogenesis (GO:0060997) | 3.66657731 |
| 49 | layer formation in cerebral cortex (GO:0021819) | 3.65241380 |
| 50 | synaptic vesicle endocytosis (GO:0048488) | 3.63659020 |
| 51 | long-term synaptic potentiation (GO:0060291) | 3.61323515 |
| 52 | cerebellar granule cell differentiation (GO:0021707) | 3.57005764 |
| 53 | primary amino compound metabolic process (GO:1901160) | 3.56569348 |
| 54 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.55705825 |
| 55 | neuromuscular process controlling balance (GO:0050885) | 3.53756631 |
| 56 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.51678144 |
| 57 | regulation of vesicle fusion (GO:0031338) | 3.51079957 |
| 58 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.50598085 |
| 59 | regulation of neurotransmitter secretion (GO:0046928) | 3.50056296 |
| 60 | cellular ketone body metabolic process (GO:0046950) | 3.49806342 |
| 61 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.48432918 |
| 62 | membrane depolarization during action potential (GO:0086010) | 3.47276477 |
| 63 | serotonin metabolic process (GO:0042428) | 3.41700937 |
| 64 | activation of protein kinase A activity (GO:0034199) | 3.41591211 |
| 65 | membrane depolarization (GO:0051899) | 3.39430361 |
| 66 | neuron recognition (GO:0008038) | 3.37892173 |
| 67 | glycine transport (GO:0015816) | 3.37781014 |
| 68 | negative regulation of dendrite development (GO:2000171) | 3.36755786 |
| 69 | regulation of neurotransmitter uptake (GO:0051580) | 3.34690320 |
| 70 | chemosensory behavior (GO:0007635) | 3.34427801 |
| 71 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.33888421 |
| 72 | behavioral defense response (GO:0002209) | 3.30125265 |
| 73 | behavioral fear response (GO:0001662) | 3.30125265 |
| 74 | regulation of neurotransmitter transport (GO:0051588) | 3.29504018 |
| 75 | calcium ion-dependent exocytosis (GO:0017156) | 3.29360507 |
| 76 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.27052249 |
| 77 | cell communication by electrical coupling (GO:0010644) | 3.25341026 |
| 78 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.23438925 |
| 79 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.23171791 |
| 80 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.21991146 |
| 81 | prepulse inhibition (GO:0060134) | 3.21282263 |
| 82 | learning (GO:0007612) | 3.18958465 |
| 83 | response to histamine (GO:0034776) | 3.18082478 |
| 84 | regulation of synapse maturation (GO:0090128) | 3.17152927 |
| 85 | membrane hyperpolarization (GO:0060081) | 3.16438642 |
| 86 | regulation of synaptic transmission (GO:0050804) | 3.16306070 |
| 87 | synaptic transmission (GO:0007268) | 3.16086410 |
| 88 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.15871376 |
| 89 | adult walking behavior (GO:0007628) | 3.12999941 |
| 90 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.12992458 |
| 91 | fear response (GO:0042596) | 3.12369457 |
| 92 | detection of calcium ion (GO:0005513) | 3.11987983 |
| 93 | behavioral response to cocaine (GO:0048148) | 3.11444017 |
| 94 | neuromuscular process (GO:0050905) | 3.09722544 |
| 95 | axonal fasciculation (GO:0007413) | 3.09662126 |
| 96 | positive regulation of neurotransmitter transport (GO:0051590) | 3.09489286 |
| 97 | ketone body metabolic process (GO:1902224) | 3.09307558 |
| 98 | positive regulation of synaptic transmission (GO:0050806) | 3.07899560 |
| 99 | response to pheromone (GO:0019236) | 3.07790047 |
| 100 | glycerophospholipid catabolic process (GO:0046475) | 3.07478126 |
| 101 | neuronal ion channel clustering (GO:0045161) | 3.07250093 |
| 102 | cellular sodium ion homeostasis (GO:0006883) | 3.06866579 |
| 103 | alanine transport (GO:0032328) | 3.06163617 |
| 104 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.06139400 |
| 105 | positive regulation of dendritic spine development (GO:0060999) | 3.06049281 |
| 106 | dendrite morphogenesis (GO:0048813) | 3.05636968 |
| 107 | auditory behavior (GO:0031223) | 3.04594372 |
| 108 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.03470642 |
| 109 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.03470642 |
| 110 | neuromuscular synaptic transmission (GO:0007274) | 3.02038415 |
| 111 | negative regulation of amino acid transport (GO:0051956) | 3.01843202 |
| 112 | response to auditory stimulus (GO:0010996) | 3.01058377 |
| 113 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.01007915 |
| 114 | dendritic spine organization (GO:0097061) | 3.00405628 |
| 115 | long term synaptic depression (GO:0060292) | 2.99622426 |
| 116 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.98717250 |
| 117 | postsynaptic membrane organization (GO:0001941) | 2.98317555 |
| 118 | positive regulation of meiosis (GO:0045836) | 2.94059700 |
| 119 | insulin secretion (GO:0030073) | 2.91169284 |
| 120 | urinary tract smooth muscle contraction (GO:0014848) | 2.90247473 |
| 121 | potassium ion homeostasis (GO:0055075) | 2.85834222 |
| 122 | axon ensheathment in central nervous system (GO:0032291) | 2.85061319 |
| 123 | central nervous system myelination (GO:0022010) | 2.85061319 |
| 124 | potassium ion transmembrane transport (GO:0071805) | 2.80709068 |
| 125 | cellular potassium ion transport (GO:0071804) | 2.80709068 |
| 126 | startle response (GO:0001964) | 2.80328234 |
| 127 | behavioral response to nicotine (GO:0035095) | 2.74047641 |
| 128 | positive regulation of meiotic cell cycle (GO:0051446) | 2.70687276 |
| 129 | inositol phosphate catabolic process (GO:0071545) | 2.69777779 |
| 130 | regulation of dendritic spine development (GO:0060998) | 2.68949502 |
| 131 | signal release (GO:0023061) | 2.68484981 |
| 132 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.68176759 |
| 133 | cochlea development (GO:0090102) | 2.67904103 |
| 134 | regulation of glucokinase activity (GO:0033131) | 2.67568349 |
| 135 | regulation of hexokinase activity (GO:1903299) | 2.67568349 |
| 136 | potassium ion transport (GO:0006813) | 2.64583629 |
| 137 | potassium ion import (GO:0010107) | 2.62611468 |
| 138 | presynaptic membrane organization (GO:0097090) | 2.60869074 |
| 139 | cerebellar Purkinje cell layer development (GO:0021680) | 2.60630295 |
| 140 | retinal cone cell development (GO:0046549) | 2.57925760 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.61070701 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.60822947 |
| 3 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.15406565 |
| 4 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.14035842 |
| 5 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.05907361 |
| 6 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.80358700 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.77377296 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.77377296 |
| 9 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.75988591 |
| 10 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.72722886 |
| 11 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.69819100 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.69261889 |
| 13 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.62039801 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.55543276 |
| 15 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.52752105 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.51992269 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.51240120 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.37441635 |
| 19 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.34677876 |
| 20 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.30176018 |
| 21 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.27386027 |
| 22 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.26930545 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.24474624 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.17965353 |
| 25 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.15897504 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.97898199 |
| 27 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.91784427 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.83470417 |
| 29 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.78207595 |
| 30 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.77411590 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.76271060 |
| 32 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.72861408 |
| 33 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.67017283 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.66633037 |
| 35 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.62846069 |
| 36 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.58479751 |
| 37 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.52859301 |
| 38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.42488817 |
| 39 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.36520442 |
| 40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.34042616 |
| 41 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.32749109 |
| 42 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31960623 |
| 43 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.31258295 |
| 44 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.30190532 |
| 45 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.27815387 |
| 46 | P300_19829295_ChIP-Seq_ESCs_Human | 1.27405072 |
| 47 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.27290886 |
| 48 | STAT3_23295773_ChIP-Seq_U87_Human | 1.25950414 |
| 49 | * AR_19668381_ChIP-Seq_PC3_Human | 1.25460677 |
| 50 | AR_25329375_ChIP-Seq_VCAP_Human | 1.24992764 |
| 51 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24674186 |
| 52 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.24627741 |
| 53 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.23400697 |
| 54 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.23041147 |
| 55 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.17831135 |
| 56 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.16997860 |
| 57 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.15932250 |
| 58 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.14943676 |
| 59 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.14437792 |
| 60 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.14046398 |
| 61 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.14046398 |
| 62 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.13070774 |
| 63 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.12216060 |
| 64 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.11173725 |
| 65 | TCF4_23295773_ChIP-Seq_U87_Human | 1.10374077 |
| 66 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.10341310 |
| 67 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.08579875 |
| 68 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.07062442 |
| 69 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.06162982 |
| 70 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.05991687 |
| 71 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.05886259 |
| 72 | VDR_22108803_ChIP-Seq_LS180_Human | 1.05774443 |
| 73 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.05178457 |
| 74 | KDM2B_26808549_Chip-Seq_K562_Human | 1.04803205 |
| 75 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.04723779 |
| 76 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.04111671 |
| 77 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.03806327 |
| 78 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.03391274 |
| 79 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.03210174 |
| 80 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.03198404 |
| 81 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.02714649 |
| 82 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.02620961 |
| 83 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.02532542 |
| 84 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.02041959 |
| 85 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01875002 |
| 86 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.01868756 |
| 87 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.01575170 |
| 88 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.01329448 |
| 89 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.00838376 |
| 90 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.00083146 |
| 91 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.00043780 |
| 92 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.98695559 |
| 93 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.98502558 |
| 94 | * SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.97310814 |
| 95 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.96951243 |
| 96 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.96286784 |
| 97 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95922485 |
| 98 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.95831465 |
| 99 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.95320196 |
| 100 | TP53_16413492_ChIP-PET_HCT116_Human | 0.95197384 |
| 101 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.94090733 |
| 102 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.93315893 |
| 103 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.92948178 |
| 104 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92646171 |
| 105 | * MYC_19829295_ChIP-Seq_ESCs_Human | 0.92495800 |
| 106 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.92483188 |
| 107 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.92464705 |
| 108 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92213776 |
| 109 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92213776 |
| 110 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91959750 |
| 111 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.91349276 |
| 112 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.90920555 |
| 113 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90855179 |
| 114 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.90706682 |
| 115 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.90397377 |
| 116 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.89637515 |
| 117 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.88787481 |
| 118 | ERA_21632823_ChIP-Seq_H3396_Human | 0.88453518 |
| 119 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.87705234 |
| 120 | RXR_22108803_ChIP-Seq_LS180_Human | 0.87274838 |
| 121 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.87091995 |
| 122 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.82128529 |
| 123 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.81820458 |
| 124 | * TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81791446 |
| 125 | * POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.81791446 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.95416548 |
| 2 | MP0003880_abnormal_central_pattern | 4.79380045 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.33860500 |
| 4 | MP0009745_abnormal_behavioral_response | 3.66780959 |
| 5 | MP0009046_muscle_twitch | 3.65064809 |
| 6 | MP0004270_analgesia | 3.48030376 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.41143736 |
| 8 | MP0002064_seizures | 3.39854180 |
| 9 | MP0001968_abnormal_touch/_nociception | 3.02950979 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.90325368 |
| 11 | MP0002272_abnormal_nervous_system | 2.87204079 |
| 12 | MP0005423_abnormal_somatic_nervous | 2.81807543 |
| 13 | MP0002822_catalepsy | 2.80162693 |
| 14 | MP0001501_abnormal_sleep_pattern | 2.68748916 |
| 15 | MP0001486_abnormal_startle_reflex | 2.57383222 |
| 16 | MP0002734_abnormal_mechanical_nocicepti | 2.51713594 |
| 17 | MP0002736_abnormal_nociception_after | 2.45856307 |
| 18 | MP0002735_abnormal_chemical_nociception | 2.31364311 |
| 19 | MP0001440_abnormal_grooming_behavior | 2.28120244 |
| 20 | MP0008569_lethality_at_weaning | 2.21842913 |
| 21 | MP0002067_abnormal_sensory_capabilities | 2.09498359 |
| 22 | MP0008877_abnormal_DNA_methylation | 2.05324225 |
| 23 | MP0002733_abnormal_thermal_nociception | 2.02628946 |
| 24 | MP0001970_abnormal_pain_threshold | 1.93716490 |
| 25 | MP0002184_abnormal_innervation | 1.75139299 |
| 26 | MP0002557_abnormal_social/conspecific_i | 1.72936458 |
| 27 | MP0003879_abnormal_hair_cell | 1.69888472 |
| 28 | MP0003329_amyloid_beta_deposits | 1.69360004 |
| 29 | MP0004924_abnormal_behavior | 1.69158161 |
| 30 | MP0005386_behavior/neurological_phenoty | 1.69158161 |
| 31 | MP0009780_abnormal_chondrocyte_physiolo | 1.67514725 |
| 32 | MP0002909_abnormal_adrenal_gland | 1.63997316 |
| 33 | MP0004811_abnormal_neuron_physiology | 1.63965588 |
| 34 | MP0004858_abnormal_nervous_system | 1.62957707 |
| 35 | MP0005646_abnormal_pituitary_gland | 1.62352933 |
| 36 | MP0003787_abnormal_imprinting | 1.59450201 |
| 37 | MP0004142_abnormal_muscle_tone | 1.55111009 |
| 38 | MP0004885_abnormal_endolymph | 1.52585932 |
| 39 | MP0000778_abnormal_nervous_system | 1.49731129 |
| 40 | MP0000955_abnormal_spinal_cord | 1.47739285 |
| 41 | MP0005379_endocrine/exocrine_gland_phen | 1.47462947 |
| 42 | MP0003195_calcinosis | 1.47391764 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.45704831 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.40302111 |
| 45 | MP0005410_abnormal_fertilization | 1.39509565 |
| 46 | MP0002882_abnormal_neuron_morphology | 1.38944592 |
| 47 | MP0003633_abnormal_nervous_system | 1.37302599 |
| 48 | MP0002837_dystrophic_cardiac_calcinosis | 1.36716783 |
| 49 | MP0001502_abnormal_circadian_rhythm | 1.32755222 |
| 50 | MP0001984_abnormal_olfaction | 1.32323317 |
| 51 | MP0001944_abnormal_pancreas_morphology | 1.32200332 |
| 52 | MP0004145_abnormal_muscle_electrophysio | 1.23710543 |
| 53 | MP0005645_abnormal_hypothalamus_physiol | 1.22736631 |
| 54 | MP0006072_abnormal_retinal_apoptosis | 1.22130689 |
| 55 | MP0003631_nervous_system_phenotype | 1.20255698 |
| 56 | MP0003122_maternal_imprinting | 1.18933245 |
| 57 | MP0003121_genomic_imprinting | 1.18457547 |
| 58 | MP0005174_abnormal_tail_pigmentation | 1.16964490 |
| 59 | MP0001905_abnormal_dopamine_level | 1.15588543 |
| 60 | MP0001188_hyperpigmentation | 1.12580800 |
| 61 | MP0008872_abnormal_physiological_respon | 1.08756881 |
| 62 | MP0001529_abnormal_vocalization | 1.06318892 |
| 63 | MP0002152_abnormal_brain_morphology | 1.04557843 |
| 64 | MP0002229_neurodegeneration | 1.02500054 |
| 65 | MP0002693_abnormal_pancreas_physiology | 0.99979178 |
| 66 | MP0002163_abnormal_gland_morphology | 0.97458841 |
| 67 | MP0002938_white_spotting | 0.97258038 |
| 68 | MP0003632_abnormal_nervous_system | 0.96892450 |
| 69 | MP0002069_abnormal_eating/drinking_beha | 0.96845195 |
| 70 | MP0000751_myopathy | 0.96715576 |
| 71 | MP0003690_abnormal_glial_cell | 0.95779434 |
| 72 | MP0005551_abnormal_eye_electrophysiolog | 0.95320191 |
| 73 | MP0004133_heterotaxia | 0.93853187 |
| 74 | MP0008875_abnormal_xenobiotic_pharmacok | 0.93505683 |
| 75 | MP0008874_decreased_physiological_sensi | 0.92435630 |
| 76 | MP0004742_abnormal_vestibular_system | 0.92053603 |
| 77 | MP0005535_abnormal_body_temperature | 0.91903214 |
| 78 | MP0001177_atelectasis | 0.91699171 |
| 79 | MP0008961_abnormal_basal_metabolism | 0.91162029 |
| 80 | MP0010329_abnormal_lipoprotein_level | 0.89959197 |
| 81 | MP0003075_altered_response_to | 0.88539510 |
| 82 | MP0000566_synostosis | 0.87625253 |
| 83 | MP0003698_abnormal_male_reproductive | 0.86490770 |
| 84 | MP0004043_abnormal_pH_regulation | 0.86078823 |
| 85 | MP0001986_abnormal_taste_sensitivity | 0.85902942 |
| 86 | MP0005253_abnormal_eye_physiology | 0.83473004 |
| 87 | MP0001963_abnormal_hearing_physiology | 0.83361031 |
| 88 | MP0000013_abnormal_adipose_tissue | 0.82475025 |
| 89 | MP0004085_abnormal_heartbeat | 0.81475887 |
| 90 | MP0004147_increased_porphyrin_level | 0.81316986 |
| 91 | MP0005332_abnormal_amino_acid | 0.80372793 |
| 92 | MP0000920_abnormal_myelination | 0.78869489 |
| 93 | MP0002078_abnormal_glucose_homeostasis | 0.77628557 |
| 94 | MP0001485_abnormal_pinna_reflex | 0.77606920 |
| 95 | MP0002876_abnormal_thyroid_physiology | 0.76943441 |
| 96 | MP0005448_abnormal_energy_balance | 0.76718873 |
| 97 | MP0003283_abnormal_digestive_organ | 0.76567943 |
| 98 | MP0002139_abnormal_hepatobiliary_system | 0.76359117 |
| 99 | MP0002928_abnormal_bile_duct | 0.75419385 |
| 100 | MP0004215_abnormal_myocardial_fiber | 0.74649540 |
| 101 | MP0000015_abnormal_ear_pigmentation | 0.73913312 |
| 102 | MP0002160_abnormal_reproductive_system | 0.73775844 |
| 103 | MP0001756_abnormal_urination | 0.73002507 |
| 104 | MP0003634_abnormal_glial_cell | 0.72606477 |
| 105 | MP0010386_abnormal_urinary_bladder | 0.72287831 |
| 106 | MP0000569_abnormal_digit_pigmentation | 0.71446281 |
| 107 | MP0005171_absent_coat_pigmentation | 0.69927676 |
| 108 | MP0000604_amyloidosis | 0.69711112 |
| 109 | MP0002752_abnormal_somatic_nervous | 0.69119655 |
| 110 | MP0002090_abnormal_vision | 0.67915498 |
| 111 | MP0002638_abnormal_pupillary_reflex | 0.67612511 |
| 112 | MP0004510_myositis | 0.67282157 |
| 113 | MP0004484_altered_response_of | 0.66214324 |
| 114 | MP0003137_abnormal_impulse_conducting | 0.64184447 |
| 115 | MP0005394_taste/olfaction_phenotype | 0.63496312 |
| 116 | MP0005499_abnormal_olfactory_system | 0.63496312 |
| 117 | MP0001664_abnormal_digestion | 0.60227437 |
| 118 | MP0005167_abnormal_blood-brain_barrier | 0.59302522 |
| 119 | MP0003123_paternal_imprinting | 0.58948509 |
| 120 | MP0004233_abnormal_muscle_weight | 0.58702914 |
| 121 | MP0010769_abnormal_survival | 0.55464889 |
| 122 | MP0001765_abnormal_ion_homeostasis | 0.53321625 |
| 123 | MP0003172_abnormal_lysosome_physiology | 0.52360094 |
| 124 | MP0010770_preweaning_lethality | 0.52347705 |
| 125 | MP0002082_postnatal_lethality | 0.52347705 |
| 126 | MP0001299_abnormal_eye_distance/ | 0.52341221 |
| 127 | MP0010768_mortality/aging | 0.52236595 |
| 128 | MP0000631_abnormal_neuroendocrine_gland | 0.51930786 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.70888495 |
| 2 | Myokymia (HP:0002411) | 7.15211734 |
| 3 | Focal seizures (HP:0007359) | 6.21126210 |
| 4 | Visual hallucinations (HP:0002367) | 5.60665302 |
| 5 | Atonic seizures (HP:0010819) | 5.33568868 |
| 6 | Progressive cerebellar ataxia (HP:0002073) | 5.32508973 |
| 7 | Febrile seizures (HP:0002373) | 5.04138439 |
| 8 | Epileptic encephalopathy (HP:0200134) | 4.99471068 |
| 9 | Absence seizures (HP:0002121) | 4.58449943 |
| 10 | Action tremor (HP:0002345) | 4.53200760 |
| 11 | Gaze-evoked nystagmus (HP:0000640) | 4.26077367 |
| 12 | Dialeptic seizures (HP:0011146) | 4.25205466 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 4.20315332 |
| 14 | Dysdiadochokinesis (HP:0002075) | 3.89523210 |
| 15 | Broad-based gait (HP:0002136) | 3.79653195 |
| 16 | Dysmetria (HP:0001310) | 3.64745746 |
| 17 | Supranuclear gaze palsy (HP:0000605) | 3.48245055 |
| 18 | Poor eye contact (HP:0000817) | 3.41727351 |
| 19 | Scanning speech (HP:0002168) | 3.39307460 |
| 20 | Depression (HP:0000716) | 3.32478735 |
| 21 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.31460030 |
| 22 | Abnormality of the lower motor neuron (HP:0002366) | 3.30762559 |
| 23 | Genetic anticipation (HP:0003743) | 3.28601144 |
| 24 | Truncal ataxia (HP:0002078) | 3.23965034 |
| 25 | Postural instability (HP:0002172) | 3.22836324 |
| 26 | Impaired smooth pursuit (HP:0007772) | 3.22412551 |
| 27 | Abnormal eating behavior (HP:0100738) | 3.18193304 |
| 28 | Hemiplegia (HP:0002301) | 3.18086780 |
| 29 | Abnormal social behavior (HP:0012433) | 3.14448897 |
| 30 | Impaired social interactions (HP:0000735) | 3.14448897 |
| 31 | Hyperventilation (HP:0002883) | 3.09793365 |
| 32 | Anxiety (HP:0000739) | 3.07155142 |
| 33 | Dysmetric saccades (HP:0000641) | 2.96348692 |
| 34 | Ankle clonus (HP:0011448) | 2.95484006 |
| 35 | Intention tremor (HP:0002080) | 2.91507765 |
| 36 | Abnormality of binocular vision (HP:0011514) | 2.90947333 |
| 37 | Diplopia (HP:0000651) | 2.90947333 |
| 38 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.86569161 |
| 39 | Status epilepticus (HP:0002133) | 2.85225812 |
| 40 | Hemiparesis (HP:0001269) | 2.82342563 |
| 41 | Amblyopia (HP:0000646) | 2.81620706 |
| 42 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.77737664 |
| 43 | Ventricular fibrillation (HP:0001663) | 2.70902536 |
| 44 | Annular pancreas (HP:0001734) | 2.67133016 |
| 45 | Ketoacidosis (HP:0001993) | 2.63107888 |
| 46 | Bradykinesia (HP:0002067) | 2.56825000 |
| 47 | Mutism (HP:0002300) | 2.50522288 |
| 48 | Stereotypic behavior (HP:0000733) | 2.49396328 |
| 49 | Spastic gait (HP:0002064) | 2.49100752 |
| 50 | Drooling (HP:0002307) | 2.47094782 |
| 51 | Excessive salivation (HP:0003781) | 2.47094782 |
| 52 | Torticollis (HP:0000473) | 2.43026102 |
| 53 | Epileptiform EEG discharges (HP:0011182) | 2.41189189 |
| 54 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.37324202 |
| 55 | Focal dystonia (HP:0004373) | 2.35968444 |
| 56 | Papilledema (HP:0001085) | 2.35413303 |
| 57 | Progressive inability to walk (HP:0002505) | 2.34039874 |
| 58 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.32099673 |
| 59 | Urinary urgency (HP:0000012) | 2.31499661 |
| 60 | Impaired vibratory sensation (HP:0002495) | 2.30179478 |
| 61 | Large for gestational age (HP:0001520) | 2.26185909 |
| 62 | Absent speech (HP:0001344) | 2.25567740 |
| 63 | Abnormality of saccadic eye movements (HP:0000570) | 2.24846713 |
| 64 | Generalized myoclonic seizures (HP:0002123) | 2.20813112 |
| 65 | EEG with generalized epileptiform discharges (HP:0011198) | 2.19968431 |
| 66 | Limb dystonia (HP:0002451) | 2.19622176 |
| 67 | Type II lissencephaly (HP:0007260) | 2.16368308 |
| 68 | Abnormality of midbrain morphology (HP:0002418) | 2.14667043 |
| 69 | Molar tooth sign on MRI (HP:0002419) | 2.14667043 |
| 70 | Gait ataxia (HP:0002066) | 2.14289947 |
| 71 | Cerebral hypomyelination (HP:0006808) | 2.13053477 |
| 72 | Akinesia (HP:0002304) | 2.11360288 |
| 73 | Fetal akinesia sequence (HP:0001989) | 2.10701755 |
| 74 | Incomplete penetrance (HP:0003829) | 2.08958623 |
| 75 | Pheochromocytoma (HP:0002666) | 2.07919197 |
| 76 | Hypsarrhythmia (HP:0002521) | 2.06936234 |
| 77 | Nephronophthisis (HP:0000090) | 2.06696834 |
| 78 | Severe visual impairment (HP:0001141) | 2.04816091 |
| 79 | Double outlet right ventricle (HP:0001719) | 2.02617401 |
| 80 | Congenital malformation of the right heart (HP:0011723) | 2.02617401 |
| 81 | Blue irides (HP:0000635) | 2.02446253 |
| 82 | Muscular hypotonia of the trunk (HP:0008936) | 2.01787568 |
| 83 | Increased circulating renin level (HP:0000848) | 2.01599995 |
| 84 | Intestinal atresia (HP:0011100) | 2.00966499 |
| 85 | Craniofacial dystonia (HP:0012179) | 2.00830417 |
| 86 | Attenuation of retinal blood vessels (HP:0007843) | 2.00826345 |
| 87 | Psychosis (HP:0000709) | 2.00559619 |
| 88 | Pointed chin (HP:0000307) | 2.00157279 |
| 89 | Congenital stationary night blindness (HP:0007642) | 1.99165254 |
| 90 | Polydipsia (HP:0001959) | 1.98702924 |
| 91 | Abnormal drinking behavior (HP:0030082) | 1.98702924 |
| 92 | Bundle branch block (HP:0011710) | 1.97646176 |
| 93 | Agitation (HP:0000713) | 1.96138475 |
| 94 | Late onset (HP:0003584) | 1.96087542 |
| 95 | Lower limb asymmetry (HP:0100559) | 1.95602335 |
| 96 | Pancreatic fibrosis (HP:0100732) | 1.95584211 |
| 97 | Tetraplegia (HP:0002445) | 1.94445834 |
| 98 | Neurofibrillary tangles (HP:0002185) | 1.92649155 |
| 99 | Cerebral inclusion bodies (HP:0100314) | 1.91833180 |
| 100 | Polyphagia (HP:0002591) | 1.91768577 |
| 101 | Neuronal loss in central nervous system (HP:0002529) | 1.89819514 |
| 102 | Rigidity (HP:0002063) | 1.88568928 |
| 103 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.88546051 |
| 104 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.88546051 |
| 105 | Resting tremor (HP:0002322) | 1.87448285 |
| 106 | Megalencephaly (HP:0001355) | 1.86295302 |
| 107 | Hyperglycemia (HP:0003074) | 1.85909521 |
| 108 | Abnormal EKG (HP:0003115) | 1.85774157 |
| 109 | Pancreatic cysts (HP:0001737) | 1.84978568 |
| 110 | Ketosis (HP:0001946) | 1.84946485 |
| 111 | Postural tremor (HP:0002174) | 1.84225643 |
| 112 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.83687658 |
| 113 | Lower limb muscle weakness (HP:0007340) | 1.83462834 |
| 114 | Limb ataxia (HP:0002070) | 1.82796109 |
| 115 | Inability to walk (HP:0002540) | 1.80917590 |
| 116 | Spastic tetraplegia (HP:0002510) | 1.80511569 |
| 117 | Abnormality of the corticospinal tract (HP:0002492) | 1.79186888 |
| 118 | Hyperthyroidism (HP:0000836) | 1.77434210 |
| 119 | Horizontal nystagmus (HP:0000666) | 1.77025580 |
| 120 | Protruding tongue (HP:0010808) | 1.76741771 |
| 121 | Hypoglycemic coma (HP:0001325) | 1.74669988 |
| 122 | Chronic hepatic failure (HP:0100626) | 1.73992070 |
| 123 | Neuroendocrine neoplasm (HP:0100634) | 1.73231450 |
| 124 | Spinal canal stenosis (HP:0003416) | 1.73191479 |
| 125 | Clonus (HP:0002169) | 1.72817693 |
| 126 | Gait imbalance (HP:0002141) | 1.71605975 |
| 127 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.70953987 |
| 128 | Sleep apnea (HP:0010535) | 1.70367309 |
| 129 | Failure to thrive in infancy (HP:0001531) | 1.69731383 |
| 130 | Abnormality of the renal medulla (HP:0100957) | 1.69337104 |
| 131 | Termporal pattern (HP:0011008) | 1.67296402 |
| 132 | Insidious onset (HP:0003587) | 1.67296402 |
| 133 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.67265068 |
| 134 | Obstructive sleep apnea (HP:0002870) | 1.67061536 |
| 135 | Hypoventilation (HP:0002791) | 1.66777477 |
| 136 | Diminished movement (HP:0002374) | 1.66769395 |
| 137 | True hermaphroditism (HP:0010459) | 1.66464699 |
| 138 | Poor suck (HP:0002033) | 1.66260255 |
| 139 | Retinal atrophy (HP:0001105) | 1.66081205 |
| 140 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.65707329 |
| 141 | Lissencephaly (HP:0001339) | 1.64472851 |
| 142 | Widely spaced teeth (HP:0000687) | 1.60009988 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 5.13312579 |
| 2 | FRK | 4.61063159 |
| 3 | EPHA4 | 4.44763449 |
| 4 | MAP3K9 | 3.69522474 |
| 5 | MAP3K4 | 2.89437097 |
| 6 | MINK1 | 2.54082607 |
| 7 | DAPK2 | 2.40355812 |
| 8 | MAP2K7 | 2.38891325 |
| 9 | FGFR2 | 2.33651678 |
| 10 | PAK6 | 2.11499636 |
| 11 | KSR2 | 2.07749769 |
| 12 | MAP4K2 | 2.07505307 |
| 13 | TRIM28 | 2.06913646 |
| 14 | NTRK2 | 2.01359428 |
| 15 | TNIK | 2.00468747 |
| 16 | MARK1 | 1.97152643 |
| 17 | CAMKK1 | 1.96604092 |
| 18 | RIPK4 | 1.92174076 |
| 19 | MAP2K4 | 1.90103405 |
| 20 | MAP3K12 | 1.88951632 |
| 21 | PRKD3 | 1.86936308 |
| 22 | PRPF4B | 1.81751094 |
| 23 | WNK4 | 1.69814472 |
| 24 | CAMKK2 | 1.67537275 |
| 25 | MAP2K6 | 1.67380197 |
| 26 | DAPK1 | 1.66784278 |
| 27 | STK38 | 1.65708581 |
| 28 | ADRBK2 | 1.62091128 |
| 29 | ARAF | 1.55563580 |
| 30 | CDK19 | 1.55194207 |
| 31 | NTRK1 | 1.53448005 |
| 32 | KSR1 | 1.51991403 |
| 33 | MAP3K13 | 1.51660372 |
| 34 | CDK5 | 1.50707091 |
| 35 | PLK2 | 1.47794968 |
| 36 | CASK | 1.47160804 |
| 37 | PRKCG | 1.39190336 |
| 38 | INSRR | 1.38873105 |
| 39 | GRK5 | 1.35040657 |
| 40 | FES | 1.30620480 |
| 41 | PNCK | 1.25674364 |
| 42 | SIK2 | 1.23188391 |
| 43 | MAP3K2 | 1.14022272 |
| 44 | CAMK1 | 1.11948331 |
| 45 | CAMK2A | 1.11638032 |
| 46 | MAPK13 | 1.09983839 |
| 47 | TYRO3 | 1.07958726 |
| 48 | PINK1 | 1.06941220 |
| 49 | UHMK1 | 1.06927927 |
| 50 | GRK1 | 1.06440893 |
| 51 | SGK223 | 1.05080283 |
| 52 | SGK494 | 1.05080283 |
| 53 | CAMK2B | 1.04382099 |
| 54 | SGK2 | 1.01221957 |
| 55 | OXSR1 | 0.99754003 |
| 56 | STK11 | 0.92829836 |
| 57 | MARK2 | 0.91744289 |
| 58 | CAMK1D | 0.91513460 |
| 59 | STK39 | 0.89983350 |
| 60 | CDK18 | 0.89372334 |
| 61 | CDK15 | 0.88580451 |
| 62 | PRKCH | 0.87614028 |
| 63 | SGK3 | 0.86887945 |
| 64 | WNK1 | 0.86140050 |
| 65 | PRKCI | 0.85610364 |
| 66 | RAF1 | 0.83716952 |
| 67 | CDK14 | 0.82548504 |
| 68 | TAOK1 | 0.82004821 |
| 69 | SGK1 | 0.80059267 |
| 70 | ALK | 0.79165768 |
| 71 | TNK2 | 0.78744448 |
| 72 | AKT3 | 0.77538533 |
| 73 | CDK11A | 0.77329009 |
| 74 | PTK2B | 0.76852163 |
| 75 | PDK1 | 0.74342671 |
| 76 | BMPR2 | 0.73044529 |
| 77 | FGFR3 | 0.71563719 |
| 78 | PDPK1 | 0.70602326 |
| 79 | STK38L | 0.68671230 |
| 80 | DYRK1A | 0.67192548 |
| 81 | PHKG2 | 0.65720656 |
| 82 | PHKG1 | 0.65720656 |
| 83 | RET | 0.65682612 |
| 84 | CAMK2G | 0.64860123 |
| 85 | MAP3K1 | 0.64818558 |
| 86 | CSNK1G2 | 0.62178583 |
| 87 | LMTK2 | 0.61601572 |
| 88 | NEK6 | 0.61360156 |
| 89 | LATS2 | 0.60481220 |
| 90 | CSNK1G3 | 0.59605237 |
| 91 | CAMK2D | 0.59107122 |
| 92 | CDC42BPA | 0.57903766 |
| 93 | CAMK4 | 0.57354211 |
| 94 | PRKAA1 | 0.56590766 |
| 95 | CSNK1G1 | 0.55921339 |
| 96 | PAK3 | 0.55418018 |
| 97 | LIMK1 | 0.55324266 |
| 98 | RIPK1 | 0.55152333 |
| 99 | RPS6KA3 | 0.54748356 |
| 100 | BRAF | 0.53887457 |
| 101 | PRKCE | 0.50112082 |
| 102 | MAP2K1 | 0.48344845 |
| 103 | SCYL2 | 0.47917674 |
| 104 | BMPR1B | 0.47870597 |
| 105 | MAP3K7 | 0.46059221 |
| 106 | CAMK1G | 0.44190218 |
| 107 | MAPK10 | 0.43535722 |
| 108 | PRKCZ | 0.43263771 |
| 109 | CSNK1D | 0.42655905 |
| 110 | FYN | 0.42217043 |
| 111 | NME1 | 0.42186400 |
| 112 | CSNK1A1 | 0.41986959 |
| 113 | PKN1 | 0.41865349 |
| 114 | CSNK1A1L | 0.41137482 |
| 115 | PRKACA | 0.39037061 |
| 116 | BRSK1 | 0.38349384 |
| 117 | FER | 0.37922855 |
| 118 | ADRBK1 | 0.37853775 |
| 119 | CSNK1E | 0.37563130 |
| 120 | WNK3 | 0.37387563 |
| 121 | TESK1 | 0.36879068 |
| 122 | ZAK | 0.36497861 |
| 123 | PRKG2 | 0.34513170 |
| 124 | PRKCA | 0.34273790 |
| 125 | PRKG1 | 0.34046715 |
| 126 | PRKCB | 0.33956210 |
| 127 | NUAK1 | 0.32232581 |
| 128 | NEK1 | 0.32163999 |
| 129 | MAPKAPK5 | 0.32158991 |
| 130 | DMPK | 0.32019261 |
| 131 | SIK3 | 0.31929622 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.13343529 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.38453807 |
| 3 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 3.18394142 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.86303204 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.85298020 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.83660652 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.82941906 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.80180166 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.70187609 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.62017500 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 2.61752020 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.24669647 |
| 13 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.23923725 |
| 14 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.22440948 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.16241593 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 2.02034867 |
| 17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.98442862 |
| 18 | Taste transduction_Homo sapiens_hsa04742 | 1.96884116 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.90571205 |
| 20 | Long-term depression_Homo sapiens_hsa04730 | 1.87870547 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.85582154 |
| 22 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.84591666 |
| 23 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.79453192 |
| 24 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.70630008 |
| 25 | Cocaine addiction_Homo sapiens_hsa05030 | 1.68494143 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.68359191 |
| 27 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.64152195 |
| 28 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.61171595 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.57870781 |
| 30 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.53542793 |
| 31 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.50513385 |
| 32 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.46675618 |
| 33 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.38197356 |
| 34 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.33623538 |
| 35 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.29437627 |
| 36 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.25988355 |
| 37 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.25648315 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.24396701 |
| 39 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.22961153 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.21632738 |
| 41 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.10799997 |
| 42 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.09218230 |
| 43 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.07147438 |
| 44 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.02457746 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.01432882 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.98858483 |
| 47 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.98808048 |
| 48 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.98362255 |
| 49 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.97490045 |
| 50 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.97099729 |
| 51 | Glioma_Homo sapiens_hsa05214 | 0.95497305 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.92775304 |
| 53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.92739500 |
| 54 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.92243482 |
| 55 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.91869433 |
| 56 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.90741070 |
| 57 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.90187769 |
| 58 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.90139014 |
| 59 | Melanogenesis_Homo sapiens_hsa04916 | 0.89091022 |
| 60 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.88572247 |
| 61 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.88279719 |
| 62 | Axon guidance_Homo sapiens_hsa04360 | 0.86674813 |
| 63 | ABC transporters_Homo sapiens_hsa02010 | 0.86264864 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.86012853 |
| 65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.84928241 |
| 66 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.84303425 |
| 67 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.83241141 |
| 68 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.82037742 |
| 69 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.80528642 |
| 70 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.77007270 |
| 71 | Phototransduction_Homo sapiens_hsa04744 | 0.76825650 |
| 72 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.73718828 |
| 73 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.71607716 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.70727709 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.68241726 |
| 76 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67035900 |
| 77 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.66437701 |
| 78 | Circadian rhythm_Homo sapiens_hsa04710 | 0.65671564 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.65356351 |
| 80 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.64905316 |
| 81 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.63533971 |
| 82 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.61968066 |
| 83 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.61934431 |
| 84 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.61248526 |
| 85 | Bile secretion_Homo sapiens_hsa04976 | 0.58987197 |
| 86 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57800713 |
| 87 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.54888457 |
| 88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.54866991 |
| 89 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53723279 |
| 90 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.53630548 |
| 91 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.53032047 |
| 92 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.52773196 |
| 93 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.52423792 |
| 94 | Histidine metabolism_Homo sapiens_hsa00340 | 0.51026118 |
| 95 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49865250 |
| 96 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.48965408 |
| 97 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.48703489 |
| 98 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.48688598 |
| 99 | Mineral absorption_Homo sapiens_hsa04978 | 0.47987535 |
| 100 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.47880958 |
| 101 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.46293383 |
| 102 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.46233040 |
| 103 | Peroxisome_Homo sapiens_hsa04146 | 0.44942986 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.43406228 |
| 105 | Protein export_Homo sapiens_hsa03060 | 0.42457580 |
| 106 | Alcoholism_Homo sapiens_hsa05034 | 0.42238250 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40471767 |
| 108 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.39995779 |
| 109 | Parkinsons disease_Homo sapiens_hsa05012 | 0.39746982 |
| 110 | Endocytosis_Homo sapiens_hsa04144 | 0.39573933 |
| 111 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.39215862 |
| 112 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.37182316 |
| 113 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37169328 |
| 114 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37103249 |
| 115 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.36347441 |
| 116 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.33934270 |
| 117 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.33546526 |
| 118 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.32272654 |
| 119 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.31939205 |
| 120 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31267946 |
| 121 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29160788 |
| 122 | Prion diseases_Homo sapiens_hsa05020 | 0.28819808 |
| 123 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.28543444 |
| 124 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28268253 |
| 125 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.26773027 |
| 126 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.26644972 |
| 127 | Alzheimers disease_Homo sapiens_hsa05010 | 0.26350442 |
| 128 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.25653581 |
| 129 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.25491001 |
| 130 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.25217293 |
| 131 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.24531202 |
| 132 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.23993353 |
| 133 | Endometrial cancer_Homo sapiens_hsa05213 | 0.21877257 |

