CNNM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.80191446
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08561911
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.80042256
4locomotory exploration behavior (GO:0035641)4.46637625
5regulation of acrosome reaction (GO:0060046)4.33477124
6sodium ion export (GO:0071436)4.32318787
7response to pheromone (GO:0019236)4.17784439
8regulation of DNA methylation (GO:0044030)4.17480730
9proline transport (GO:0015824)4.09527166
10multicellular organism reproduction (GO:0032504)4.08567458
11water-soluble vitamin biosynthetic process (GO:0042364)4.02210441
12synaptic vesicle maturation (GO:0016188)4.01596504
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96870993
14piRNA metabolic process (GO:0034587)3.96453501
15regulation of female gonad development (GO:2000194)3.93873146
16cellular potassium ion homeostasis (GO:0030007)3.90383949
17positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.88723490
18DNA methylation involved in gamete generation (GO:0043046)3.86129985
19synaptic vesicle exocytosis (GO:0016079)3.80426250
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76407692
21regulation of ARF protein signal transduction (GO:0032012)3.72069301
22membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.67601580
23retinal cone cell development (GO:0046549)3.65630561
24interkinetic nuclear migration (GO:0022027)3.65218048
25regulation of glutamate receptor signaling pathway (GO:1900449)3.61999852
26regulation of clathrin-mediated endocytosis (GO:2000369)3.60824177
27sulfation (GO:0051923)3.60514164
28serotonin metabolic process (GO:0042428)3.55299522
29regulation of synaptic vesicle exocytosis (GO:2000300)3.55129764
30vocalization behavior (GO:0071625)3.53531865
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53361257
32positive regulation of synapse maturation (GO:0090129)3.53165827
33membrane repolarization during action potential (GO:0086011)3.51349970
34layer formation in cerebral cortex (GO:0021819)3.48954959
35activation of protein kinase A activity (GO:0034199)3.47803927
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.38310224
37glutamate secretion (GO:0014047)3.34957718
38regulation of mesoderm development (GO:2000380)3.34541688
39protein localization to synapse (GO:0035418)3.31750278
40glutamate receptor signaling pathway (GO:0007215)3.30078969
41primary amino compound metabolic process (GO:1901160)3.29617511
42neuromuscular process controlling posture (GO:0050884)3.28020472
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.27374782
44NADH dehydrogenase complex assembly (GO:0010257)3.27374782
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27374782
46cell communication by electrical coupling (GO:0010644)3.24741039
47alanine transport (GO:0032328)3.22177839
48regulation of cAMP-dependent protein kinase activity (GO:2000479)3.18945303
49regulation of female receptivity (GO:0045924)3.18265776
50protein complex biogenesis (GO:0070271)3.15184390
51regulation of synaptic vesicle transport (GO:1902803)3.14923917
52regulation of meiosis I (GO:0060631)3.13482799
53parturition (GO:0007567)3.13377632
54positive regulation of gastrulation (GO:2000543)3.12281862
55cerebellar Purkinje cell differentiation (GO:0021702)3.10701748
56negative regulation of hormone biosynthetic process (GO:0032353)3.10426142
57negative regulation of hormone metabolic process (GO:0032351)3.10426142
58neuronal action potential propagation (GO:0019227)3.09752905
59meiotic cell cycle (GO:0051321)3.09752276
60glycine transport (GO:0015816)3.08939436
61synaptic transmission, glutamatergic (GO:0035249)3.08179711
62long-term memory (GO:0007616)3.07442347
63neuromuscular process controlling balance (GO:0050885)3.06486909
64neuronal action potential (GO:0019228)3.05854743
65response to dietary excess (GO:0002021)3.05508195
66positive regulation of meiosis (GO:0045836)3.01976128
67neurotransmitter secretion (GO:0007269)2.99502518
68protein polyglutamylation (GO:0018095)2.98839570
69cell proliferation in forebrain (GO:0021846)2.97100221
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96918068
71exploration behavior (GO:0035640)2.96362227
72regulation of membrane repolarization (GO:0060306)2.96277354
73neurotransmitter-gated ion channel clustering (GO:0072578)2.93982394
74positive regulation of membrane potential (GO:0045838)2.92550626
75biotin metabolic process (GO:0006768)2.91450426
76negative regulation of transcription regulatory region DNA binding (GO:2000678)2.89742292
77cerebellar granule cell differentiation (GO:0021707)2.88390803
78gamma-aminobutyric acid transport (GO:0015812)2.88164751
79prepulse inhibition (GO:0060134)2.87926976
80cellular sodium ion homeostasis (GO:0006883)2.87569557
81CDP-diacylglycerol metabolic process (GO:0046341)2.87283513
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87039985
83cardiovascular system development (GO:0072358)2.85129298
84positive regulation of meiotic cell cycle (GO:0051446)2.84186787
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.83107259
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82640220
87regulation of gene silencing by RNA (GO:0060966)2.82528164
88regulation of posttranscriptional gene silencing (GO:0060147)2.82528164
89regulation of gene silencing by miRNA (GO:0060964)2.82528164
90regulation of DNA endoreduplication (GO:0032875)2.81952934
91long term synaptic depression (GO:0060292)2.81634720
92gamma-aminobutyric acid signaling pathway (GO:0007214)2.81258979
93dendritic spine morphogenesis (GO:0060997)2.80170132
94mitochondrial respiratory chain complex assembly (GO:0033108)2.79209435
95detection of light stimulus involved in sensory perception (GO:0050962)2.78815202
96detection of light stimulus involved in visual perception (GO:0050908)2.78815202
97regulation of calcium ion-dependent exocytosis (GO:0017158)2.77477197
98male meiosis I (GO:0007141)2.77257601
99membrane depolarization during action potential (GO:0086010)2.76193849
100neuron-neuron synaptic transmission (GO:0007270)2.75970253
101neuron cell-cell adhesion (GO:0007158)2.75399002
102positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74113851
103monoubiquitinated protein deubiquitination (GO:0035520)2.71665464
104negative regulation of response to food (GO:0032096)2.68413335
105negative regulation of appetite (GO:0032099)2.68413335
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67424862
107regulation of action potential (GO:0098900)2.67375883
108female gamete generation (GO:0007292)2.67366032
109negative regulation of adenylate cyclase activity (GO:0007194)2.67331291
110potassium ion homeostasis (GO:0055075)2.67061498
111synaptic vesicle endocytosis (GO:0048488)2.67051284
112positive regulation of fibroblast migration (GO:0010763)2.66796781
113CDP-diacylglycerol biosynthetic process (GO:0016024)2.66561652
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65854773
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65309884
116negative regulation of amino acid transport (GO:0051956)2.65128170
117cellular response to ATP (GO:0071318)2.64811345
118negative regulation of cyclase activity (GO:0031280)2.63702809
119regulation of neuronal synaptic plasticity (GO:0048168)2.63682871
120regulation of potassium ion transmembrane transport (GO:1901379)2.63257417
121phosphorelay signal transduction system (GO:0000160)2.63186530
122regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62942351
123membrane repolarization (GO:0086009)2.62503205
124negative regulation of systemic arterial blood pressure (GO:0003085)2.60730878
125cerebellar Purkinje cell layer development (GO:0021680)2.60588898
126regulation of skeletal muscle contraction (GO:0014819)2.59771977
127positive regulation of action potential (GO:0045760)2.59529291
128positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59266812
129action potential (GO:0001508)2.58726504
130ovulation cycle (GO:0042698)2.58411183
131transmission of nerve impulse (GO:0019226)2.58121153
132positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57799934
133epithelial cilium movement (GO:0003351)2.57663214
134protein K48-linked deubiquitination (GO:0071108)2.56068603
135negative regulation of sodium ion transport (GO:0010766)2.55742569
136stress granule assembly (GO:0034063)2.55081906
137regulation of histone H3-K9 methylation (GO:0051570)2.54907301
138neurotransmitter transport (GO:0006836)2.54854111
139female mating behavior (GO:0060180)2.53763203
140DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.53579516
141membrane hyperpolarization (GO:0060081)2.52702119
142dentate gyrus development (GO:0021542)2.52470488
143negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.52259365
144positive regulation of dendritic spine morphogenesis (GO:0061003)2.51137602
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.51118634
146regulation of glucocorticoid secretion (GO:2000849)2.49636240
147presynaptic membrane assembly (GO:0097105)2.47933546
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.46890426
149indolalkylamine metabolic process (GO:0006586)2.46567160
150positive regulation of sodium ion transmembrane transport (GO:1902307)2.46134124
151mating behavior (GO:0007617)2.45830484
152regulation of postsynaptic membrane potential (GO:0060078)2.45711267
153membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45655905
154positive regulation of synaptic transmission, GABAergic (GO:0032230)2.45357823
155chemosensory behavior (GO:0007635)2.43846217
156regulation of synapse maturation (GO:0090128)2.43278372
157cAMP catabolic process (GO:0006198)2.42992721
158somite development (GO:0061053)2.42409180
159behavioral defense response (GO:0002209)2.42335679
160behavioral fear response (GO:0001662)2.42335679
161positive regulation of cardiac muscle cell differentiation (GO:2000727)2.41990852
162regulation of synaptic transmission, glutamatergic (GO:0051966)2.41678223
163cellular anion homeostasis (GO:0030002)2.41639074
164tachykinin receptor signaling pathway (GO:0007217)2.41583152
165photoreceptor cell development (GO:0042461)2.41515374
166cell differentiation in hindbrain (GO:0021533)2.41147133
167regulation of synapse structural plasticity (GO:0051823)2.40573971
168snRNA transcription (GO:0009301)2.39630437
169indole-containing compound metabolic process (GO:0042430)2.39482836
170positive regulation of vesicle fusion (GO:0031340)2.39014927
171regulation of neurotransmitter levels (GO:0001505)2.38705454
172presynaptic membrane organization (GO:0097090)2.38638137
173carnitine shuttle (GO:0006853)2.38440797
174synaptic vesicle docking involved in exocytosis (GO:0016081)2.37375967
175neuromuscular process (GO:0050905)2.37268788
176low-density lipoprotein particle clearance (GO:0034383)2.37157734
177response to histamine (GO:0034776)2.37032348
178spinal cord motor neuron differentiation (GO:0021522)2.36238291
179negative regulation of astrocyte differentiation (GO:0048712)2.36031732
180DNA alkylation (GO:0006305)2.35987055
181DNA methylation (GO:0006306)2.35987055
182positive regulation of histone H3-K4 methylation (GO:0051571)2.35677815
183vitamin catabolic process (GO:0009111)2.35539564
184fat-soluble vitamin catabolic process (GO:0042363)2.35539564
185growth hormone secretion (GO:0030252)2.35452110
186potassium ion import (GO:0010107)2.35439297
187righting reflex (GO:0060013)2.34144901
188neuron recognition (GO:0008038)2.33928374
189reproduction (GO:0000003)2.33085174
190regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.31384032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.75140594
2EZH2_22144423_ChIP-Seq_EOC_Human3.75635287
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95649989
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86519607
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73750359
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72843248
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.68325093
8REST_21632747_ChIP-Seq_MESCs_Mouse2.65643685
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.51220725
10VDR_22108803_ChIP-Seq_LS180_Human2.34105767
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28567033
12* REST_18959480_ChIP-ChIP_MESCs_Mouse2.28012670
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24322338
14DROSHA_22980978_ChIP-Seq_HELA_Human2.10123770
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09384520
16EWS_26573619_Chip-Seq_HEK293_Human2.01100645
17TAF15_26573619_Chip-Seq_HEK293_Human1.99726821
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96456968
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90519470
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.89277626
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.88789393
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88772401
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.87511994
24KDM2B_26808549_Chip-Seq_K562_Human1.87259041
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87004833
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86583657
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84771840
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81325916
29* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80291467
30IRF1_19129219_ChIP-ChIP_H3396_Human1.79730498
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79083059
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78690665
33FUS_26573619_Chip-Seq_HEK293_Human1.76293700
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76158809
35GBX2_23144817_ChIP-Seq_PC3_Human1.74873413
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73091808
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.73012916
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72051060
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72051060
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.71017909
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70838993
42P300_19829295_ChIP-Seq_ESCs_Human1.69325552
43RNF2_27304074_Chip-Seq_NSC_Mouse1.69149330
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68491764
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68148599
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67916840
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67278670
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61893897
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.60457402
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56787752
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54422198
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54029360
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54029360
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53916094
55IGF1R_20145208_ChIP-Seq_DFB_Human1.53408580
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50526436
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50301252
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.49205389
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49188063
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.46157289
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44714982
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42417187
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41314947
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41019631
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40958613
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40513215
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40001703
68TCF4_23295773_ChIP-Seq_U87_Human1.39848811
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37428492
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37213276
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.37011063
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36997455
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36117476
74CBP_20019798_ChIP-Seq_JUKART_Human1.34627712
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34627712
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33946788
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33396786
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33379948
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33188228
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.32927615
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30679709
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30567284
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30068201
84ER_23166858_ChIP-Seq_MCF-7_Human1.29893230
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28829790
86ZNF263_19887448_ChIP-Seq_K562_Human1.28538418
87* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27071174
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.26972857
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25350075
90STAT3_23295773_ChIP-Seq_U87_Human1.24481683
91* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24329369
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.23341104
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23148913
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.22191588
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22150132
96CLOCK_20551151_ChIP-Seq_293T_Human1.21884488
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21051275
98AR_19668381_ChIP-Seq_PC3_Human1.20655769
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20417582
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19725074
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19409437
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.18434871
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17829178
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17659501
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.16802550
106BCAT_22108803_ChIP-Seq_LS180_Human1.16692519
107CREB1_26743006_Chip-Seq_LNCaP_Human1.16436022
108RXR_22108803_ChIP-Seq_LS180_Human1.16022809
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15458854
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13874912
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13823019
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13574724
113SMAD4_21799915_ChIP-Seq_A2780_Human1.13351828
114SMC4_20622854_ChIP-Seq_HELA_Human1.13313973
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12612922
116RUNX2_22187159_ChIP-Seq_PCA_Human1.11931183
117POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09663600
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09528894
119ZNF274_21170338_ChIP-Seq_K562_Hela1.09086885
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.08379534
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.07799903
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06579543
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.06416512
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.06263228
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06048165
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05872283
127MYC_18940864_ChIP-ChIP_HL60_Human1.05847985
128KLF4_19829295_ChIP-Seq_ESCs_Human1.04771158
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.04402816
130TP53_22573176_ChIP-Seq_HFKS_Human1.03648628
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03421852
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02879352
133ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02787803
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02225521
135AR_25329375_ChIP-Seq_VCAP_Human1.01935978
136STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01461455
137GATA1_26923725_Chip-Seq_HPCs_Mouse1.01378495
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01103478
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99755343
140* KDM2B_26808549_Chip-Seq_DND41_Human0.99496882
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.99324501
142AR_21572438_ChIP-Seq_LNCaP_Human0.98647319
143HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98611260
144* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98281916
145GATA1_19941826_ChIP-Seq_K562_Human0.97291106
146AHR_22903824_ChIP-Seq_MCF-7_Human0.96234096
147* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96182654
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96066941
149* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95720086
150* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95359540
151CTCF_27219007_Chip-Seq_Bcells_Human0.95043633
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94843104
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94031690
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.93437053
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93409313
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.93240406
157TCF4_22108803_ChIP-Seq_LS180_Human0.93099256
158NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93057104
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92910286
160KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92907212
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92804572
162AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92571266
163TP53_16413492_ChIP-PET_HCT116_Human0.92400116
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92273394
165SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91258902
166* RING1B_27294783_Chip-Seq_NPCs_Mouse0.90934224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.69981054
2MP0006292_abnormal_olfactory_placode3.87853884
3MP0008877_abnormal_DNA_methylation3.65755177
4MP0003635_abnormal_synaptic_transmissio2.96145617
5MP0000013_abnormal_adipose_tissue2.92469944
6MP0004270_analgesia2.85754908
7MP0005670_abnormal_white_adipose2.78833229
8MP0003718_maternal_effect2.73373380
9MP0000569_abnormal_digit_pigmentation2.72892171
10MP0002160_abnormal_reproductive_system2.53932944
11MP0003646_muscle_fatigue2.49381167
12MP0002909_abnormal_adrenal_gland2.45929674
13MP0009046_muscle_twitch2.42603786
14MP0005666_abnormal_adipose_tissue2.40715228
15MP0003880_abnormal_central_pattern2.40235291
16MP0003283_abnormal_digestive_organ2.39350971
17MP0003329_amyloid_beta_deposits2.27839835
18MP0003890_abnormal_embryonic-extraembry2.24342219
19MP0002063_abnormal_learning/memory/cond2.22707486
20MP0005645_abnormal_hypothalamus_physiol2.20464902
21MP0004185_abnormal_adipocyte_glucose2.19654605
22MP0004885_abnormal_endolymph2.15234318
23MP0008961_abnormal_basal_metabolism2.09262546
24MP0001501_abnormal_sleep_pattern2.05950095
25MP0009780_abnormal_chondrocyte_physiolo2.05276122
26MP0000003_abnormal_adipose_tissue2.00000742
27MP0002064_seizures1.98054320
28MP0009745_abnormal_behavioral_response1.96865936
29MP0005389_reproductive_system_phenotype1.94886312
30MP0002877_abnormal_melanocyte_morpholog1.94481006
31MP0005375_adipose_tissue_phenotype1.92171283
32MP0002734_abnormal_mechanical_nocicepti1.86023265
33MP0002736_abnormal_nociception_after1.83871314
34MP0009379_abnormal_foot_pigmentation1.83429661
35MP0002572_abnormal_emotion/affect_behav1.77678171
36MP0002733_abnormal_thermal_nociception1.77347155
37MP0001440_abnormal_grooming_behavior1.77001822
38MP0002272_abnormal_nervous_system1.74703682
39MP0004142_abnormal_muscle_tone1.74604496
40MP0001502_abnormal_circadian_rhythm1.72239196
41MP0008789_abnormal_olfactory_epithelium1.68578455
42MP0003121_genomic_imprinting1.67646771
43MP0002837_dystrophic_cardiac_calcinosis1.63982891
44MP0002638_abnormal_pupillary_reflex1.58273812
45MP0004043_abnormal_pH_regulation1.56333830
46MP0001485_abnormal_pinna_reflex1.55603068
47MP0001986_abnormal_taste_sensitivity1.55365575
48MP0001970_abnormal_pain_threshold1.54461347
49MP0001486_abnormal_startle_reflex1.54443324
50MP0003172_abnormal_lysosome_physiology1.52876753
51MP0004133_heterotaxia1.47410855
52MP0005535_abnormal_body_temperature1.46955427
53MP0001661_extended_life_span1.44940313
54MP0004130_abnormal_muscle_cell1.43102096
55MP0002822_catalepsy1.39593070
56MP0003195_calcinosis1.37854528
57MP0004858_abnormal_nervous_system1.35137600
58MP0002078_abnormal_glucose_homeostasis1.33714483
59MP0002254_reproductive_system_inflammat1.32844025
60MP0004742_abnormal_vestibular_system1.32535598
61MP0000049_abnormal_middle_ear1.32164829
62MP0002876_abnormal_thyroid_physiology1.31931606
63MP0006276_abnormal_autonomic_nervous1.29293402
64MP0005423_abnormal_somatic_nervous1.28624358
65MP0002067_abnormal_sensory_capabilities1.28520969
66MP0003879_abnormal_hair_cell1.26354074
67MP0001905_abnormal_dopamine_level1.25972379
68MP0001188_hyperpigmentation1.25504725
69MP0005499_abnormal_olfactory_system1.24019539
70MP0005394_taste/olfaction_phenotype1.24019539
71MP0005386_behavior/neurological_phenoty1.23623341
72MP0004924_abnormal_behavior1.23623341
73MP0004264_abnormal_extraembryonic_tissu1.22847576
74MP0006072_abnormal_retinal_apoptosis1.22325734
75MP0002653_abnormal_ependyma_morphology1.21231115
76MP0005174_abnormal_tail_pigmentation1.20664459
77MP0002138_abnormal_hepatobiliary_system1.20595811
78MP0003119_abnormal_digestive_system1.19962660
79MP0005076_abnormal_cell_differentiation1.18879609
80MP0000604_amyloidosis1.18409039
81MP0008569_lethality_at_weaning1.16950031
82MP0003123_paternal_imprinting1.16826731
83MP0001944_abnormal_pancreas_morphology1.14191783
84MP0002971_abnormal_brown_adipose1.14154247
85MP0004811_abnormal_neuron_physiology1.13909865
86MP0002066_abnormal_motor_capabilities/c1.12539892
87MP0002210_abnormal_sex_determination1.10975963
88MP0002184_abnormal_innervation1.09927157
89MP0001919_abnormal_reproductive_system1.08953824
90MP0003045_fibrosis1.08273589
91MP0002557_abnormal_social/conspecific_i1.07894066
92MP0001968_abnormal_touch/_nociception1.07733215
93MP0005646_abnormal_pituitary_gland1.07638070
94MP0010386_abnormal_urinary_bladder1.06009570
95MP0000955_abnormal_spinal_cord1.05677245
96MP0002928_abnormal_bile_duct1.03774910
97MP0002693_abnormal_pancreas_physiology1.03721246
98MP0001963_abnormal_hearing_physiology1.03472638
99MP0004215_abnormal_myocardial_fiber1.03161966
100MP0003136_yellow_coat_color1.02980808
101MP0002938_white_spotting1.02694081
102MP0000427_abnormal_hair_cycle1.02350393
103MP0010329_abnormal_lipoprotein_level1.01484411
104MP0000026_abnormal_inner_ear1.00939571
105MP0001929_abnormal_gametogenesis0.99791651
106MP0005253_abnormal_eye_physiology0.98936992
107MP0000778_abnormal_nervous_system0.97718555
108MP0008775_abnormal_heart_ventricle0.97569055
109MP0002234_abnormal_pharynx_morphology0.97113214
110MP0003690_abnormal_glial_cell0.96938942
111MP0005448_abnormal_energy_balance0.96452323
112MP0003633_abnormal_nervous_system0.96316482
113MP0000230_abnormal_systemic_arterial0.96136448
114MP0003122_maternal_imprinting0.95389961
115MP0002735_abnormal_chemical_nociception0.95301139
116MP0002069_abnormal_eating/drinking_beha0.95060922
117MP0005334_abnormal_fat_pad0.94811436
118MP0003705_abnormal_hypodermis_morpholog0.94646474
119MP0002752_abnormal_somatic_nervous0.94505983
120MP0005379_endocrine/exocrine_gland_phen0.94431009
121MP0001881_abnormal_mammary_gland0.93616099
122MP0003937_abnormal_limbs/digits/tail_de0.93420461
123MP0003953_abnormal_hormone_level0.92989597
124MP0002152_abnormal_brain_morphology0.91637263
125MP0002229_neurodegeneration0.91239467
126MP0001293_anophthalmia0.90878520
127MP0000653_abnormal_sex_gland0.90764001
128MP0002882_abnormal_neuron_morphology0.90447962
129MP0003011_delayed_dark_adaptation0.89776092
130MP0005410_abnormal_fertilization0.89706806
131MP0002118_abnormal_lipid_homeostasis0.89117753
132MP0001984_abnormal_olfaction0.88312026
133MP0003567_abnormal_fetal_cardiomyocyte0.87087640
134MP0009250_abnormal_appendicular_skeleto0.86652016
135MP0005195_abnormal_posterior_eye0.86485511
136MP0004145_abnormal_muscle_electrophysio0.84141913
137MP0008872_abnormal_physiological_respon0.84087451
138MP0003938_abnormal_ear_development0.83237393
139MP0005395_other_phenotype0.82116466
140MP0002102_abnormal_ear_morphology0.81866726
141MP0003787_abnormal_imprinting0.81594947
142MP0003698_abnormal_male_reproductive0.81517344
143MP0005452_abnormal_adipose_tissue0.81424207
144MP0008875_abnormal_xenobiotic_pharmacok0.80686771
145MP0001299_abnormal_eye_distance/0.80564994
146MP0001348_abnormal_lacrimal_gland0.79144377
147MP0005551_abnormal_eye_electrophysiolog0.78804271
148MP0005310_abnormal_salivary_gland0.78004139
149MP0000631_abnormal_neuroendocrine_gland0.76073523
150MP0002970_abnormal_white_adipose0.75340421
151MP0004233_abnormal_muscle_weight0.73850375
152MP0003959_abnormal_lean_body0.73821098
153MP0009115_abnormal_fat_cell0.73547726

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.08021913
2Visual hallucinations (HP:0002367)3.87798728
3Focal seizures (HP:0007359)3.80486235
4Myokymia (HP:0002411)3.53644723
5Osteomalacia (HP:0002749)3.44364258
6Hyperglycinuria (HP:0003108)3.37672029
7Insulin-resistant diabetes mellitus (HP:0000831)3.17872501
8Pancreatic cysts (HP:0001737)3.14841470
9Abnormality of midbrain morphology (HP:0002418)3.14030801
10Molar tooth sign on MRI (HP:0002419)3.14030801
11Nephronophthisis (HP:0000090)3.12032554
12Congenital stationary night blindness (HP:0007642)3.10239686
13Abnormal eating behavior (HP:0100738)2.99553254
14Decreased circulating renin level (HP:0003351)2.98495870
15Epileptic encephalopathy (HP:0200134)2.98047661
16Abnormality of the lower motor neuron (HP:0002366)2.96975657
17Generalized tonic-clonic seizures (HP:0002069)2.94345945
18Febrile seizures (HP:0002373)2.90242037
19Gout (HP:0001997)2.90135317
20Genetic anticipation (HP:0003743)2.89757779
21Abnormal social behavior (HP:0012433)2.87886099
22Impaired social interactions (HP:0000735)2.87886099
23Pancreatic fibrosis (HP:0100732)2.87749120
24Ketoacidosis (HP:0001993)2.85651943
25Oligomenorrhea (HP:0000876)2.81870524
26Excessive salivation (HP:0003781)2.80311109
27Drooling (HP:0002307)2.80311109
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.79713940
29Poor eye contact (HP:0000817)2.78686690
30Atonic seizures (HP:0010819)2.76216726
31Abnormality of the labia minora (HP:0012880)2.75296955
32Hemiplegia (HP:0002301)2.74661834
33Polyphagia (HP:0002591)2.72287053
34Global brain atrophy (HP:0002283)2.68498527
35Action tremor (HP:0002345)2.67233006
36Abnormality of the renal medulla (HP:0100957)2.66695687
37Hyperglycemia (HP:0003074)2.62334330
38Chronic hepatic failure (HP:0100626)2.60933994
39Absence seizures (HP:0002121)2.59427112
40Increased circulating renin level (HP:0000848)2.56976123
41Hand muscle atrophy (HP:0009130)2.54843287
42Congenital, generalized hypertrichosis (HP:0004540)2.54601416
43Dialeptic seizures (HP:0011146)2.54473438
44Supranuclear gaze palsy (HP:0000605)2.52657360
45Abnormality of serine family amino acid metabolism (HP:0010894)2.51835938
46Abnormality of glycine metabolism (HP:0010895)2.51835938
47True hermaphroditism (HP:0010459)2.51664079
48Hemiparesis (HP:0001269)2.51466118
49EEG with generalized epileptiform discharges (HP:0011198)2.48936147
50Methylmalonic acidemia (HP:0002912)2.47943025
51Astrocytoma (HP:0009592)2.46278295
52Abnormality of the astrocytes (HP:0100707)2.46278295
53Shawl scrotum (HP:0000049)2.44123524
54Epileptiform EEG discharges (HP:0011182)2.43449222
55Abnormality of the renal cortex (HP:0011035)2.43297985
56Short tibia (HP:0005736)2.42147945
57Septo-optic dysplasia (HP:0100842)2.40737038
58Hyperglycinemia (HP:0002154)2.36771535
59Dysdiadochokinesis (HP:0002075)2.35968927
60Abnormality of the middle phalanges of the toes (HP:0010183)2.35236407
61Abnormal ciliary motility (HP:0012262)2.34442757
62Absent/shortened dynein arms (HP:0200106)2.34406069
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.34406069
64Medial flaring of the eyebrow (HP:0010747)2.33241967
65Hypsarrhythmia (HP:0002521)2.30907389
66Resting tremor (HP:0002322)2.30453450
67Depression (HP:0000716)2.28292862
68Abolished electroretinogram (ERG) (HP:0000550)2.28150543
69Impaired smooth pursuit (HP:0007772)2.27903383
70Tetraplegia (HP:0002445)2.25999273
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25243538
72Short hallux (HP:0010109)2.24445800
73Ependymoma (HP:0002888)2.23421147
74Abnormal drinking behavior (HP:0030082)2.22761364
75Polydipsia (HP:0001959)2.22761364
76Decreased central vision (HP:0007663)2.22541103
77Distal upper limb amyotrophy (HP:0007149)2.21527666
78Upper limb amyotrophy (HP:0009129)2.21527666
79Spinal muscular atrophy (HP:0007269)2.21284951
80Congenital sensorineural hearing impairment (HP:0008527)2.20396113
81Abnormality of ocular smooth pursuit (HP:0000617)2.18665211
82Abnormality of the renal collecting system (HP:0004742)2.17949375
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17881874
84Pendular nystagmus (HP:0012043)2.16720647
85Broad-based gait (HP:0002136)2.16411589
86Attenuation of retinal blood vessels (HP:0007843)2.16280135
87Abnormality of the proximal phalanges of the hand (HP:0009834)2.15899309
88Agitation (HP:0000713)2.15267249
89Tubular atrophy (HP:0000092)2.14935464
90Mutism (HP:0002300)2.14013707
91Status epilepticus (HP:0002133)2.13640643
92Aplasia/Hypoplasia of the hallux (HP:0008362)2.12124562
93Dysmetria (HP:0001310)2.11541752
94Abnormal number of erythroid precursors (HP:0012131)2.11342597
95Bony spicule pigmentary retinopathy (HP:0007737)2.11256592
96Small hand (HP:0200055)2.10269236
97Clumsiness (HP:0002312)2.09853347
98Hypoplasia of the ulna (HP:0003022)2.09590462
99Abnormality of DNA repair (HP:0003254)2.09325765
100Aplasia/Hypoplasia of the patella (HP:0006498)2.09157872
101Abnormal respiratory epithelium morphology (HP:0012253)2.08073769
102Abnormal respiratory motile cilium morphology (HP:0005938)2.08073769
103Hyperinsulinemic hypoglycemia (HP:0000825)2.07678485
104Hypoplasia of the uterus (HP:0000013)2.07621731
105Cerebral inclusion bodies (HP:0100314)2.07308039
106Optic nerve hypoplasia (HP:0000609)2.07193837
107Abnormal respiratory motile cilium physiology (HP:0012261)2.06621321
108Hyperventilation (HP:0002883)2.06286136
109Cerebral aneurysm (HP:0004944)2.06189395
110Methylmalonic aciduria (HP:0012120)2.02253089
111Patellar aplasia (HP:0006443)2.02195334
112Hypercortisolism (HP:0001578)2.00105300
113Abnormality of the nasal septum (HP:0000419)2.00096392
114Impaired vibration sensation in the lower limbs (HP:0002166)1.99966608
115Turricephaly (HP:0000262)1.99550447
116Supernumerary spleens (HP:0009799)1.99233646
117Intention tremor (HP:0002080)1.99174760
118Short femoral neck (HP:0100864)1.98132099
119Abnormality of polysaccharide metabolism (HP:0011012)1.97884704
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97884704
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97884704
122Neoplasm of the heart (HP:0100544)1.97154649
123Progressive cerebellar ataxia (HP:0002073)1.97141014
124Oligodactyly (hands) (HP:0001180)1.96895836
125Absent thumb (HP:0009777)1.96880645
126Abnormality of cells of the erythroid lineage (HP:0012130)1.95875925
127Lip pit (HP:0100267)1.95649239
128Hypoplasia of the fovea (HP:0007750)1.95249429
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.95249429
130Restlessness (HP:0000711)1.94732335
131Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94553656
132Failure to thrive in infancy (HP:0001531)1.94375535
133Abnormal rod and cone electroretinograms (HP:0008323)1.93439212
134Renal cortical cysts (HP:0000803)1.93294372
135Hypoglycemic seizures (HP:0002173)1.92886050
136Urinary glycosaminoglycan excretion (HP:0003541)1.91551257
137Mucopolysacchariduria (HP:0008155)1.91551257
138Aplasia/Hypoplasia of the ulna (HP:0006495)1.91134986
139Abnormality of renin-angiotensin system (HP:0000847)1.90084476
140Preauricular pit (HP:0004467)1.89347617
141Periauricular skin pits (HP:0100277)1.89347617
142Truncal ataxia (HP:0002078)1.88827687
143Sensorimotor neuropathy (HP:0007141)1.88781486
144Cystic liver disease (HP:0006706)1.88428729
145Symphalangism affecting the phalanges of the hand (HP:0009773)1.88181121
146Chorioretinal atrophy (HP:0000533)1.87872271
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87713708
148Cortical visual impairment (HP:0100704)1.87115539
149Dysostosis multiplex (HP:0000943)1.85782835
150Anxiety (HP:0000739)1.85671729
151Pheochromocytoma (HP:0002666)1.84931904
152Insomnia (HP:0100785)1.84930529
153Aplasia/hypoplasia of the uterus (HP:0008684)1.84014077
154Stenosis of the external auditory canal (HP:0000402)1.83705975
155Gait imbalance (HP:0002141)1.83464489
156Skin nodule (HP:0200036)1.83360690
157Confusion (HP:0001289)1.83352689
158Ketosis (HP:0001946)1.83298912
159Neuronal loss in central nervous system (HP:0002529)1.81911530
160Abnormality of the phalanges of the 5th finger (HP:0004213)1.81205474
161Postural instability (HP:0002172)1.80468803
162Abnormality of the intrinsic pathway (HP:0010989)1.78219062
163Abnormality of purine metabolism (HP:0004352)1.77353677
164Male pseudohermaphroditism (HP:0000037)1.76901385
165Furrowed tongue (HP:0000221)1.76699884
166Dysmetric saccades (HP:0000641)1.76679638
167Horizontal nystagmus (HP:0000666)1.75746972
168Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74757989
169Sclerocornea (HP:0000647)1.73511787
170Heterotopia (HP:0002282)1.73233576
171Gaze-evoked nystagmus (HP:0000640)1.73064525
172Atrioventricular block (HP:0001678)1.73034295
173Limb dystonia (HP:0002451)1.72553818
174Amblyopia (HP:0000646)1.72409275
175Anterior segment dysgenesis (HP:0007700)1.72217388
176Genital tract atresia (HP:0001827)1.72151548
177Rhinitis (HP:0012384)1.72113131
1783-Methylglutaconic aciduria (HP:0003535)1.72087668
179Protruding tongue (HP:0010808)1.71749968
180Bradykinesia (HP:0002067)1.71662452
181Fibular aplasia (HP:0002990)1.71361810
182Abnormality of salivation (HP:0100755)1.70719201
183Oligodontia (HP:0000677)1.70327504
184Delayed puberty (HP:0000823)1.70219059
185Abnormality of renal resorption (HP:0011038)1.70168501
186Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70000544
187Short 1st metacarpal (HP:0010034)1.70000544
188Enlarged penis (HP:0000040)1.69826566
189Congenital primary aphakia (HP:0007707)1.69479773
190Impulsivity (HP:0100710)1.69294266
191Torticollis (HP:0000473)1.67627821
192Abnormality of calcium-phosphate metabolism (HP:0100530)1.67051957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48309675
2WNK33.53248717
3TLK13.39567311
4NTRK33.35348070
5MAP3K93.18713902
6BMPR1B2.88510853
7TAOK12.66921355
8KSR22.49430948
9PAK62.48894693
10MAP3K42.46857631
11LATS22.45928591
12PRKD32.40985021
13EPHA42.39570362
14ZAK2.24419284
15GRK12.24270415
16ACVR1B2.24118764
17ADRBK22.20608009
18NTRK12.14807761
19CASK1.98323480
20STK391.85737228
21NTRK21.80473062
22CAMK1D1.69892005
23STK381.60011828
24NUAK11.59476748
25CAMK1G1.58512776
26DAPK21.58477167
27TRIB31.56606949
28TAOK31.56474672
29MAP2K41.52064725
30MINK11.49966362
31OXSR11.49820005
32LATS11.46612782
33KSR11.45894234
34AKT31.43690658
35PNCK1.40515966
36MAP3K61.40401427
37CDK121.35934487
38STK161.34551783
39TYRO31.31005759
40INSRR1.23575577
41MARK11.17350622
42GRK51.16929388
43MAP3K131.14424813
44RET1.14209283
45CDK51.13254863
46RIPK11.12859079
47STK111.12390783
48RAF11.11499374
49FGFR21.09283677
50ARAF1.07474990
51PRKAA11.06032838
52PDGFRA1.06002056
53MST41.05510184
54EEF2K1.04785751
55ALK1.03549506
56MAPK151.02196324
57MAP3K21.01691900
58WNK10.98628290
59PRKCG0.98386379
60CDC70.97170936
61BRAF0.96240417
62MAP4K20.93846391
63CAMKK10.93220502
64AURKA0.92713902
65ADRBK10.91738467
66DYRK20.91710868
67ICK0.90577720
68STK38L0.88733702
69VRK10.87506807
70EPHA20.86540210
71PIK3CA0.86442875
72CAMKK20.86243053
73FER0.83720345
74TAF10.82794667
75TXK0.80861489
76PAK30.80403623
77STK30.79072820
78SCYL20.77662437
79MAPK130.76638721
80NEK10.76048313
81CDK90.75815435
82MAPK100.75221485
83MARK20.75167624
84PRKAA20.74487878
85MAP2K70.73852196
86SGK30.73662335
87STK240.73021294
88HIPK20.70337758
89SGK2230.70013340
90SGK4940.70013340
91SGK20.70009723
92PLK20.68888041
93PRKACA0.67802076
94MUSK0.67187830
95SIK10.66384069
96PDPK10.66166502
97MTOR0.65659197
98LMTK20.65364287
99MELK0.64004553
100CDC42BPA0.63874763
101SGK10.62964200
102MAPKAPK50.62840507
103PINK10.62223769
104CAMK2A0.61621926
105CSNK1G20.61316528
106PLK10.61129360
107DYRK1A0.60931328
108JAK20.60559055
109DAPK10.60368706
110GSK3A0.59615174
111EPHA30.59568832
112PHKG20.58954116
113PHKG10.58954116
114PRKCE0.58139939
115ERBB40.57697915
116CSNK1G10.56989800
117SIK20.56584500
118RPS6KA30.56449821
119PKN10.56355652
120TIE10.55927400
121TEC0.55779802
122CDK190.55666754
123MAPKAPK30.55591496
124MAP3K50.55042166
125UHMK10.54001872
126PRKD20.53332108
127MAP3K10.52827999
128PRKCH0.52331317
129PRKCI0.52079535
130PRKG10.51875107
131RPS6KA60.51774070
132PTK60.50838695
133WNK40.50583751
134DDR20.50373637
135CSNK1D0.47880946
136PDK10.47802973
137CHUK0.47146742
138CDK150.46870593
139PRKCZ0.46857987
140PTK2B0.46591520
141TGFBR10.45596023
142MKNK20.45563256
143PDGFRB0.45146931
144TNIK0.45086390
145PRKCQ0.44903296
146FES0.44903122
147BRSK10.44551196
148NLK0.44190288
149NEK20.43892817
150NEK60.42929045
151CAMK10.42841954
152PIM10.42829355
153CDK140.42681242
154IKBKB0.42187293
155CSNK1E0.42136856
156CSNK1A10.37558070
157RPS6KA20.36490299
158ERBB20.36300494
159DYRK30.35235250

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.96866820
2Nicotine addiction_Homo sapiens_hsa050332.81016500
3Phototransduction_Homo sapiens_hsa047442.49411246
4Synaptic vesicle cycle_Homo sapiens_hsa047212.36207157
5Nitrogen metabolism_Homo sapiens_hsa009102.35476768
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30210270
7Basal transcription factors_Homo sapiens_hsa030222.26552333
8Insulin secretion_Homo sapiens_hsa049112.16325264
9GABAergic synapse_Homo sapiens_hsa047272.13070812
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01254691
11Type II diabetes mellitus_Homo sapiens_hsa049301.97017941
12Long-term potentiation_Homo sapiens_hsa047201.93647217
13Oxidative phosphorylation_Homo sapiens_hsa001901.93094763
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82848263
15Linoleic acid metabolism_Homo sapiens_hsa005911.80179446
16Morphine addiction_Homo sapiens_hsa050321.78855678
17Circadian rhythm_Homo sapiens_hsa047101.78413049
18Amphetamine addiction_Homo sapiens_hsa050311.74962063
19Glutamatergic synapse_Homo sapiens_hsa047241.74884709
20Vitamin B6 metabolism_Homo sapiens_hsa007501.68781857
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67483304
22Circadian entrainment_Homo sapiens_hsa047131.65710484
23Cardiac muscle contraction_Homo sapiens_hsa042601.63575359
24Salivary secretion_Homo sapiens_hsa049701.63162990
25Ribosome_Homo sapiens_hsa030101.60618433
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.60460177
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60334003
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57907012
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56250061
30Cocaine addiction_Homo sapiens_hsa050301.54807523
31RNA polymerase_Homo sapiens_hsa030201.53218356
32Taste transduction_Homo sapiens_hsa047421.51687498
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48549027
34Homologous recombination_Homo sapiens_hsa034401.46838131
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45544798
36Parkinsons disease_Homo sapiens_hsa050121.45379713
37Olfactory transduction_Homo sapiens_hsa047401.44410521
38Fatty acid biosynthesis_Homo sapiens_hsa000611.41624295
39Caffeine metabolism_Homo sapiens_hsa002321.40623933
40RNA degradation_Homo sapiens_hsa030181.35326279
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33148014
42Fanconi anemia pathway_Homo sapiens_hsa034601.31140337
43Dopaminergic synapse_Homo sapiens_hsa047281.30053086
44Renin secretion_Homo sapiens_hsa049241.26449458
45Huntingtons disease_Homo sapiens_hsa050161.25909090
46mTOR signaling pathway_Homo sapiens_hsa041501.24604212
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24213969
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24187137
49AMPK signaling pathway_Homo sapiens_hsa041521.23622318
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20612134
51Glycerolipid metabolism_Homo sapiens_hsa005611.18970108
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18298654
53Glucagon signaling pathway_Homo sapiens_hsa049221.17806859
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.17543510
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17450272
56Cholinergic synapse_Homo sapiens_hsa047251.14600838
57GnRH signaling pathway_Homo sapiens_hsa049121.12446364
58Vitamin digestion and absorption_Homo sapiens_hsa049771.11874626
59Estrogen signaling pathway_Homo sapiens_hsa049151.11358859
60Gastric acid secretion_Homo sapiens_hsa049711.11208936
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10010848
62Alzheimers disease_Homo sapiens_hsa050101.09757341
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09672946
64Protein export_Homo sapiens_hsa030601.06700233
65PPAR signaling pathway_Homo sapiens_hsa033201.04828901
66Glycerophospholipid metabolism_Homo sapiens_hsa005641.04395111
67Retinol metabolism_Homo sapiens_hsa008301.04304854
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04239587
69Long-term depression_Homo sapiens_hsa047301.03290471
70Insulin signaling pathway_Homo sapiens_hsa049101.03124632
71Oxytocin signaling pathway_Homo sapiens_hsa049211.01569167
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99621305
73cAMP signaling pathway_Homo sapiens_hsa040240.98251625
74Ether lipid metabolism_Homo sapiens_hsa005650.98212386
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97517650
76Sulfur metabolism_Homo sapiens_hsa009200.97017277
77Dorso-ventral axis formation_Homo sapiens_hsa043200.96364652
78Arginine biosynthesis_Homo sapiens_hsa002200.96272584
79Collecting duct acid secretion_Homo sapiens_hsa049660.95716830
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.95251102
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94036582
82Glioma_Homo sapiens_hsa052140.94018096
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93758331
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.93451967
85Oocyte meiosis_Homo sapiens_hsa041140.93313017
86Insulin resistance_Homo sapiens_hsa049310.93156099
87Chemical carcinogenesis_Homo sapiens_hsa052040.92453154
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91936079
89Gap junction_Homo sapiens_hsa045400.91303158
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90752910
91Bile secretion_Homo sapiens_hsa049760.90403018
92Thyroid hormone synthesis_Homo sapiens_hsa049180.89441770
93Calcium signaling pathway_Homo sapiens_hsa040200.89178922
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87450400
95Tryptophan metabolism_Homo sapiens_hsa003800.86874077
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86387165
97Choline metabolism in cancer_Homo sapiens_hsa052310.86143438
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86001387
99Butanoate metabolism_Homo sapiens_hsa006500.84633573
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83050331
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82489971
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.82241461
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81524443
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80932796
105Serotonergic synapse_Homo sapiens_hsa047260.79647457
106ABC transporters_Homo sapiens_hsa020100.78288399
107ErbB signaling pathway_Homo sapiens_hsa040120.76751389
108Sulfur relay system_Homo sapiens_hsa041220.76116140
109Hedgehog signaling pathway_Homo sapiens_hsa043400.73493433
110Pancreatic secretion_Homo sapiens_hsa049720.73348475
111Nucleotide excision repair_Homo sapiens_hsa034200.72377504
112Inositol phosphate metabolism_Homo sapiens_hsa005620.71660859
113Systemic lupus erythematosus_Homo sapiens_hsa053220.71038481
114Selenocompound metabolism_Homo sapiens_hsa004500.68909430
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.68683106
116Fatty acid metabolism_Homo sapiens_hsa012120.68559526
117Alcoholism_Homo sapiens_hsa050340.68189845
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66310096
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66282227
120Regulation of autophagy_Homo sapiens_hsa041400.65430776
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64119845
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61337469
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61100076
124Basal cell carcinoma_Homo sapiens_hsa052170.59935752
125MAPK signaling pathway_Homo sapiens_hsa040100.58445794
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55791726
127Ovarian steroidogenesis_Homo sapiens_hsa049130.54383094
128Biosynthesis of amino acids_Homo sapiens_hsa012300.52605222
129TGF-beta signaling pathway_Homo sapiens_hsa043500.52522539
130Lysosome_Homo sapiens_hsa041420.52453198
131Melanogenesis_Homo sapiens_hsa049160.50581241
132Renal cell carcinoma_Homo sapiens_hsa052110.50444262
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.49541159
134Dilated cardiomyopathy_Homo sapiens_hsa054140.48274408
135FoxO signaling pathway_Homo sapiens_hsa040680.47992004
136Non-small cell lung cancer_Homo sapiens_hsa052230.47636695
137Arachidonic acid metabolism_Homo sapiens_hsa005900.47131163
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47048888
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46881612
140Purine metabolism_Homo sapiens_hsa002300.45638852
141Endometrial cancer_Homo sapiens_hsa052130.44987484
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.44274529
143Ras signaling pathway_Homo sapiens_hsa040140.43338428
144Melanoma_Homo sapiens_hsa052180.43020809
145Hippo signaling pathway_Homo sapiens_hsa043900.42913939
146Bladder cancer_Homo sapiens_hsa052190.42042781
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41972330
148Prion diseases_Homo sapiens_hsa050200.41461875
149Prolactin signaling pathway_Homo sapiens_hsa049170.40568590
150VEGF signaling pathway_Homo sapiens_hsa043700.40038423
151Fructose and mannose metabolism_Homo sapiens_hsa000510.39912389
152Wnt signaling pathway_Homo sapiens_hsa043100.38907099
153Propanoate metabolism_Homo sapiens_hsa006400.38863443
154Mineral absorption_Homo sapiens_hsa049780.38747590

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