CNNM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation, ncRNA-mediated (GO:0040033)5.19909036
2regulation of translation, ncRNA-mediated (GO:0045974)5.19909036
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.19909036
4lymphoid progenitor cell differentiation (GO:0002320)3.94096252
5histone H3-K4 trimethylation (GO:0080182)3.88723804
6regulation of cholesterol homeostasis (GO:2000188)3.82500321
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.77906316
8negative regulation of cell size (GO:0045792)3.77612574
9peptidyl-lysine trimethylation (GO:0018023)3.55335136
10histone H3-K4 methylation (GO:0051568)3.54297077
11proline biosynthetic process (GO:0006561)3.47399359
12embryonic process involved in female pregnancy (GO:0060136)3.39719626
13focal adhesion assembly (GO:0048041)3.36067499
14cell-substrate adherens junction assembly (GO:0007045)3.36067499
15negative regulation of glial cell proliferation (GO:0060253)3.34724122
16creatine metabolic process (GO:0006600)3.32641560
17mannose metabolic process (GO:0006013)3.31578258
18intracellular estrogen receptor signaling pathway (GO:0030520)3.31128908
19protein-lipid complex assembly (GO:0065005)3.27731355
20regulation of regulatory T cell differentiation (GO:0045589)3.25386144
21plasma lipoprotein particle assembly (GO:0034377)3.20185134
22regulation of cholesterol biosynthetic process (GO:0045540)3.18387637
23apoptotic process involved in morphogenesis (GO:0060561)3.18272467
24tolerance induction (GO:0002507)3.17346054
25adherens junction assembly (GO:0034333)3.15209819
26peptidyl-glutamic acid carboxylation (GO:0017187)3.14403052
27protein carboxylation (GO:0018214)3.14403052
28regulation of extracellular matrix disassembly (GO:0010715)3.13715854
29histone H4-K12 acetylation (GO:0043983)3.13561291
30NADH metabolic process (GO:0006734)3.13391344
31proline metabolic process (GO:0006560)3.13083598
32negative regulation of erythrocyte differentiation (GO:0045647)3.12183877
33regulation of gamma-delta T cell differentiation (GO:0045586)3.10885286
34forebrain neuron differentiation (GO:0021879)3.10661869
35energy homeostasis (GO:0097009)3.08187550
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.07995297
37very-low-density lipoprotein particle assembly (GO:0034379)3.07942486
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.07936054
39regulation of DNA endoreduplication (GO:0032875)3.07894563
40positive thymic T cell selection (GO:0045059)3.04595097
41axon ensheathment in central nervous system (GO:0032291)3.00174842
42central nervous system myelination (GO:0022010)3.00174842
43lateral sprouting from an epithelium (GO:0060601)2.98245999
44skeletal muscle contraction (GO:0003009)2.97469198
45histone H3-K36 demethylation (GO:0070544)2.95249721
46positive T cell selection (GO:0043368)2.94665289
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94461796
48regulation of cholesterol metabolic process (GO:0090181)2.94096458
49response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.92670365
50histone lysine methylation (GO:0034968)2.90450053
51response to muramyl dipeptide (GO:0032495)2.90156395
52regulation of glial cell proliferation (GO:0060251)2.89492610
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89026287
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87210687
553-UTR-mediated mRNA stabilization (GO:0070935)2.86809499
56face development (GO:0060324)2.86529502
57negative regulation of viral release from host cell (GO:1902187)2.85877645
58skeletal muscle adaptation (GO:0043501)2.84630071
59histone H4-K16 acetylation (GO:0043984)2.84317564
60regulation of interleukin-12 biosynthetic process (GO:0045075)2.84168798
61maternal placenta development (GO:0001893)2.84102215
62glycogen catabolic process (GO:0005980)2.83134586
63fructose metabolic process (GO:0006000)2.79620710
64regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79566747
65somatic stem cell division (GO:0048103)2.78618903
66glucan catabolic process (GO:0009251)2.78342119
67regulation of NFAT protein import into nucleus (GO:0051532)2.77403105
68neuronal stem cell maintenance (GO:0097150)2.77026666
69regulation of chromatin binding (GO:0035561)2.76193890
70histone H2A acetylation (GO:0043968)2.74660377
71positive regulation of Cdc42 GTPase activity (GO:0043089)2.74589301
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74570867
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73430650
74positive regulation of action potential (GO:0045760)2.73022310
75spliceosomal tri-snRNP complex assembly (GO:0000244)2.71458740
76negative regulation of fibrinolysis (GO:0051918)2.70401634
77L-alpha-amino acid transmembrane transport (GO:1902475)2.70279563
78coronary vasculature morphogenesis (GO:0060977)2.69819104
79limb bud formation (GO:0060174)2.68773254
80regulation of glucose import in response to insulin stimulus (GO:2001273)2.68565882
81histone H3-K9 methylation (GO:0051567)2.68245547
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65709208
83RNA stabilization (GO:0043489)2.64994299
84mRNA stabilization (GO:0048255)2.64994299
85regulation of ARF GTPase activity (GO:0032312)2.64771804
86Golgi transport vesicle coating (GO:0048200)2.64646104
87COPI coating of Golgi vesicle (GO:0048205)2.64646104
88activation of Rac GTPase activity (GO:0032863)2.63887316
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63730802
90cellular response to epidermal growth factor stimulus (GO:0071364)2.63028907
91regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.62659664
92megakaryocyte development (GO:0035855)2.62105961
93cellular polysaccharide catabolic process (GO:0044247)2.61933717
94ionotropic glutamate receptor signaling pathway (GO:0035235)2.61089654
95histone H3 deacetylation (GO:0070932)2.61012589
96regulation of gamma-delta T cell activation (GO:0046643)2.60913504
97regulation of extracellular matrix organization (GO:1903053)2.60427802
98negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60339417
99histone H3-K9 demethylation (GO:0033169)2.59412948
100protein localization to chromosome, centromeric region (GO:0071459)2.58905890
101response to laminar fluid shear stress (GO:0034616)2.58900818
102pinocytosis (GO:0006907)2.58295488
103negative regulation of fatty acid biosynthetic process (GO:0045717)2.56506842
104regulation of pigment cell differentiation (GO:0050932)2.56436220
105histone H4 deacetylation (GO:0070933)2.56084227
106peptidyl-lysine methylation (GO:0018022)2.56078299
107mitotic sister chromatid cohesion (GO:0007064)2.55747417
108cell-cell junction maintenance (GO:0045217)2.55174599
109auditory behavior (GO:0031223)2.54724014
110postsynaptic membrane organization (GO:0001941)2.52900779
111paraxial mesoderm development (GO:0048339)2.52618141
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.52468748
113mRNA splice site selection (GO:0006376)2.52292531
114regulation of respiratory system process (GO:0044065)2.51425783
115urea cycle (GO:0000050)2.50842661
116pre-miRNA processing (GO:0031054)2.50214942
117regulation of fatty acid beta-oxidation (GO:0031998)2.49143111
118cellular hyperosmotic response (GO:0071474)2.48795295
119modulation by virus of host process (GO:0019054)2.48788736
120antigen processing and presentation of endogenous antigen (GO:0019883)2.48724533
121regulation of histone H3-K27 methylation (GO:0061085)2.48133856
122regulation of oligodendrocyte differentiation (GO:0048713)2.47050634
123lung lobe morphogenesis (GO:0060463)2.47029412
124positive regulation of gamma-delta T cell activation (GO:0046645)2.46611022
125poly(A)+ mRNA export from nucleus (GO:0016973)2.46276545
126regulation of ARF protein signal transduction (GO:0032012)2.45678537
127regulation of fatty acid biosynthetic process (GO:0042304)2.45180769
128regulation of bile acid biosynthetic process (GO:0070857)2.44217209
129purinergic nucleotide receptor signaling pathway (GO:0035590)2.44134718
130phospholipid efflux (GO:0033700)2.43997473
131T cell selection (GO:0045058)2.43610243
132glucose 6-phosphate metabolic process (GO:0051156)2.43446757
133positive regulation of myotube differentiation (GO:0010831)2.43306006
134negative regulation of myotube differentiation (GO:0010832)2.43294190
135protein localization to kinetochore (GO:0034501)2.42952500
136histone lysine demethylation (GO:0070076)2.42438425
137negative regulation of necroptotic process (GO:0060546)2.41967919
138G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.41542216
139regulation of respiratory gaseous exchange (GO:0043576)2.41467117
140cellular response to virus (GO:0098586)2.40691628
141urea metabolic process (GO:0019627)2.40344622
142histone methylation (GO:0016571)2.38697685
143intestinal cholesterol absorption (GO:0030299)2.38625619
144hindbrain development (GO:0030902)2.38199365
145regulation of fibrinolysis (GO:0051917)2.38144610
146negative regulation of granulocyte differentiation (GO:0030853)2.37856831
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37461287
148negative regulation of cell killing (GO:0031342)2.37461287
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37312281
150histone H4-K5 acetylation (GO:0043981)2.36643972
151histone H4-K8 acetylation (GO:0043982)2.36643972
152negative regulation of mRNA processing (GO:0050686)2.35435078
153gonadal mesoderm development (GO:0007506)2.35240028
154regulation of apoptotic cell clearance (GO:2000425)2.35216507
155epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.34967162
156positive regulation of histone deacetylation (GO:0031065)2.34259007
157positive regulation of oligodendrocyte differentiation (GO:0048714)2.33501150
158definitive hemopoiesis (GO:0060216)2.33240452
159modulation by symbiont of host cellular process (GO:0044068)2.33044423
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.32676058
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.32676058
162modulation by symbiont of host immune response (GO:0052553)2.32676058
163positive regulation by symbiont of host defense response (GO:0052509)2.32676058
164modulation by symbiont of host defense response (GO:0052031)2.32676058
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32676058
166regulation of RNA export from nucleus (GO:0046831)2.32122528
167modulation by virus of host morphology or physiology (GO:0019048)2.31383924
168negative regulation of actin filament bundle assembly (GO:0032232)2.31232020
169regulation of gene expression by genetic imprinting (GO:0006349)2.30379511
170negative regulation of fatty acid transport (GO:2000192)2.30349028
171embryonic hemopoiesis (GO:0035162)2.29934274
172striated muscle atrophy (GO:0014891)2.29390119
173regulation of nucleobase-containing compound transport (GO:0032239)2.28839176
174histone demethylation (GO:0016577)2.28826021
175T-helper 1 type immune response (GO:0042088)2.27877583
176histone H4 acetylation (GO:0043967)2.26279300
177cell proliferation in forebrain (GO:0021846)2.25853197
178regulation of B cell receptor signaling pathway (GO:0050855)2.25149090
179positive regulation of Notch signaling pathway (GO:0045747)2.24887240
180mast cell activation involved in immune response (GO:0002279)2.24639378
181mast cell degranulation (GO:0043303)2.24639378
182sympathetic nervous system development (GO:0048485)2.23976204
183histone H3-K9 modification (GO:0061647)2.23612724
184regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.23300412
185embryonic camera-type eye morphogenesis (GO:0048596)2.22603318
186head development (GO:0060322)2.21577636
187thymic T cell selection (GO:0045061)2.21455529
188negative T cell selection (GO:0043383)2.20901073
189negative regulation of epidermal cell differentiation (GO:0045605)2.19265931
190dendritic spine morphogenesis (GO:0060997)2.19161088
191negative regulation of cAMP-mediated signaling (GO:0043951)2.18632772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.45639383
2SCL_19346495_ChIP-Seq_HPC-7_Human3.10547873
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.94771489
4EZH2_22144423_ChIP-Seq_EOC_Human2.92304837
5DROSHA_22980978_ChIP-Seq_HELA_Human2.78445804
6LXR_22292898_ChIP-Seq_THP-1_Human2.76879214
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55691540
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.52008024
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41125979
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40624018
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37749719
12* RACK7_27058665_Chip-Seq_MCF-7_Human2.30480757
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29756099
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25746450
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.17993154
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16775388
17AR_21572438_ChIP-Seq_LNCaP_Human2.15999833
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.14057401
19GBX2_23144817_ChIP-Seq_PC3_Human2.09994835
20ZNF263_19887448_ChIP-Seq_K562_Human2.09309002
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05782024
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02418642
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02107926
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.99603185
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95505596
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95505596
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.93907776
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89551522
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89551522
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89551522
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86456532
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80538145
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.76946135
34* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74045383
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73112855
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72053570
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.71990884
38P68_20966046_ChIP-Seq_HELA_Human1.70782103
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70688251
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.68839281
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68759202
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67765399
43VDR_21846776_ChIP-Seq_THP-1_Human1.67237088
44UTX_26944678_Chip-Seq_JUKART_Human1.66749840
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65337193
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64999218
47* RXR_22158963_ChIP-Seq_LIVER_Mouse1.64041232
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63970584
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62487107
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60698817
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60013342
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59779927
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59531446
54* MAF_26560356_Chip-Seq_TH2_Human1.59313942
55TCF7_22412390_ChIP-Seq_EML_Mouse1.57337765
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56711696
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55520396
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.54731096
59SMC4_20622854_ChIP-Seq_HELA_Human1.54189646
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53082900
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.49822316
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49647599
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49555304
64RUNX_20019798_ChIP-Seq_JUKART_Human1.49511855
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46709927
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45966478
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45966478
68CREB1_26743006_Chip-Seq_LNCaP_Human1.45476554
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.44930517
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.44591400
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43908997
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43861300
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43110132
74* RUNX1_27514584_Chip-Seq_MCF-7_Human1.41409515
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41376169
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41065916
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40948767
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40441526
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40171978
80NCOR1_26117541_ChIP-Seq_K562_Human1.39908338
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39449642
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39329077
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38932699
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.38157779
85MYC_22102868_ChIP-Seq_BL_Human1.37664148
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.34978035
87* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34334649
88TP53_16413492_ChIP-PET_HCT116_Human1.33953440
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33767557
90IRF1_19129219_ChIP-ChIP_H3396_Human1.33222143
91CIITA_25753668_ChIP-Seq_RAJI_Human1.32862336
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.31829712
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31643166
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31621905
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29976315
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.28823523
97* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28649488
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28307903
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28201498
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27622147
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25410841
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23932516
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23361545
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22231452
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22203474
106* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22193994
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21371131
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20691185
109KDM2B_26808549_Chip-Seq_DND41_Human1.20345198
110BCOR_27268052_Chip-Seq_Bcells_Human1.19888375
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19745628
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19297422
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17874631
114SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17801374
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.17765645
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17107227
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16987661
118MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16517788
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15980158
120VDR_24763502_ChIP-Seq_THP-1_Human1.15898317
121SPI1_23127762_ChIP-Seq_K562_Human1.15890030
122TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14950035
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13902961
124TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13425920
125* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13333203
126PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13205633
127* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12410392
128ELF1_20517297_ChIP-Seq_JURKAT_Human1.11598373
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11496492
130AHR_22903824_ChIP-Seq_MCF-7_Human1.10812506
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10287119
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10087398
133SMAD4_21799915_ChIP-Seq_A2780_Human1.09582540
134* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09357226
135DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09075165
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09056236
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08354175
138ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07906965
139ATF3_27146783_Chip-Seq_COLON_Human1.07683899
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07677458
141* KDM2B_26808549_Chip-Seq_K562_Human1.07073626
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06390049
143* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06387483
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06381668
145CTCF_27219007_Chip-Seq_Bcells_Human1.06354603
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05675593
147ETS1_21867929_ChIP-Seq_TH2_Mouse1.05267258
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04543599
149SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04434523
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02195609
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01762603
152RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01173569
153MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01019883
154RARB_24833708_ChIP-Seq_LIVER_Mouse1.01004158
155E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00375734
156SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00092669
157CTCF_21964334_Chip-Seq_Bcells_Human0.99643583
158RARA_24833708_ChIP-Seq_LIVER_Mouse0.99608060
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99198775
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98847008
161BCL6_27268052_Chip-Seq_Bcells_Human0.98439169
162LXR_22158963_ChIP-Seq_LIVER_Mouse0.97604964
163* CBX2_27304074_Chip-Seq_ESCs_Mouse0.97535893
164RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96227202
165GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96110608
166CLOCK_20551151_ChIP-Seq_293T_Human0.95975967
167MYB_26560356_Chip-Seq_TH1_Human0.94418439
168ERG_21242973_ChIP-ChIP_JURKAT_Human0.94253470
169RARB_27405468_Chip-Seq_BRAIN_Mouse0.94133175
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93576462
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92040999
172MAF_26560356_Chip-Seq_TH1_Human0.90723022
173TCF4_23295773_ChIP-Seq_U87_Human0.89734532
174RNF2_27304074_Chip-Seq_NSC_Mouse0.89311005
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.88633289
176TBL1_22424771_ChIP-Seq_293T_Human0.87686936
177* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87286283
178* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86944642
179SMAD3_21741376_ChIP-Seq_HESCs_Human0.85820962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.00971176
2MP0003787_abnormal_imprinting3.50585512
3MP0002009_preneoplasia3.49828262
4MP0008057_abnormal_DNA_replication3.25462233
5MP0000566_synostosis3.23104090
6MP0006292_abnormal_olfactory_placode2.99952826
7MP0005076_abnormal_cell_differentiation2.83051447
8MP0008260_abnormal_autophagy2.74115841
9MP0005409_darkened_coat_color2.67933906
10MP0008877_abnormal_DNA_methylation2.65135308
11MP0003705_abnormal_hypodermis_morpholog2.55185644
12MP0005058_abnormal_lysosome_morphology2.45970823
13MP0000751_myopathy2.42718912
14MP0008007_abnormal_cellular_replicative2.41449171
15MP0004185_abnormal_adipocyte_glucose2.34138411
16MP0002396_abnormal_hematopoietic_system2.32851148
17MP0003941_abnormal_skin_development2.23452882
18MP0009840_abnormal_foam_cell2.21511234
19MP0005174_abnormal_tail_pigmentation2.15009279
20MP0003172_abnormal_lysosome_physiology2.08516740
21MP0004233_abnormal_muscle_weight2.07900578
22MP0004264_abnormal_extraembryonic_tissu1.96358421
23MP0000747_muscle_weakness1.92520445
24MP0001188_hyperpigmentation1.86292617
25MP0008995_early_reproductive_senescence1.85866951
26MP0001849_ear_inflammation1.83974779
27MP0003191_abnormal_cellular_cholesterol1.78598390
28MP0003436_decreased_susceptibility_to1.76376955
29MP0004087_abnormal_muscle_fiber1.76186446
30MP0002095_abnormal_skin_pigmentation1.71692526
31MP0003763_abnormal_thymus_physiology1.70275450
32MP0003690_abnormal_glial_cell1.70105591
33MP0003866_abnormal_defecation1.66555649
34MP0005360_urolithiasis1.65023407
35MP0000015_abnormal_ear_pigmentation1.65002565
36MP0010094_abnormal_chromosome_stability1.64760091
37MP0005666_abnormal_adipose_tissue1.64476209
38MP0000569_abnormal_digit_pigmentation1.62793144
39MP0004145_abnormal_muscle_electrophysio1.62611540
40MP0009278_abnormal_bone_marrow1.62300473
41MP0005646_abnormal_pituitary_gland1.59411471
42MP0004130_abnormal_muscle_cell1.59072924
43MP0004858_abnormal_nervous_system1.58666363
44MP0009333_abnormal_splenocyte_physiolog1.57066961
45MP0002166_altered_tumor_susceptibility1.56970585
46MP0005365_abnormal_bile_salt1.55897569
47MP0002089_abnormal_postnatal_growth/wei1.54459109
48MP0001661_extended_life_span1.51473984
49MP0002139_abnormal_hepatobiliary_system1.51384755
50MP0009046_muscle_twitch1.51376468
51MP0005423_abnormal_somatic_nervous1.50999795
52MP0004381_abnormal_hair_follicle1.50620013
53MP0003121_genomic_imprinting1.50298228
54MP0000383_abnormal_hair_follicle1.49541942
55MP0000759_abnormal_skeletal_muscle1.48890345
56MP0010630_abnormal_cardiac_muscle1.48374822
57MP0001486_abnormal_startle_reflex1.48308635
58MP0010234_abnormal_vibrissa_follicle1.48246129
59MP0004808_abnormal_hematopoietic_stem1.47879470
60MP0003123_paternal_imprinting1.47370861
61MP0005671_abnormal_response_to1.46241063
62MP0002735_abnormal_chemical_nociception1.45214389
63MP0002269_muscular_atrophy1.44614745
64MP0002106_abnormal_muscle_physiology1.43502113
65MP0002736_abnormal_nociception_after1.42795928
66MP0008961_abnormal_basal_metabolism1.41262126
67MP0002132_abnormal_respiratory_system1.40613891
68MP0003938_abnormal_ear_development1.39505933
69MP0009672_abnormal_birth_weight1.38423491
70MP0009379_abnormal_foot_pigmentation1.36467982
71MP0000920_abnormal_myelination1.35202317
72MP0005375_adipose_tissue_phenotype1.33332200
73MP0000733_abnormal_muscle_development1.32015725
74MP0000749_muscle_degeneration1.30502967
75MP0000003_abnormal_adipose_tissue1.28924914
76MP0005330_cardiomyopathy1.27938989
77MP0003283_abnormal_digestive_organ1.27882648
78MP0003453_abnormal_keratinocyte_physiol1.25920732
79MP0003646_muscle_fatigue1.24273111
80MP0002751_abnormal_autonomic_nervous1.21212276
81MP0001346_abnormal_lacrimal_gland1.20188848
82MP0003303_peritoneal_inflammation1.19852307
83MP0000049_abnormal_middle_ear1.19071237
84MP0000703_abnormal_thymus_morphology1.18908225
85MP0001730_embryonic_growth_arrest1.18673093
86MP0010329_abnormal_lipoprotein_level1.18601100
87MP0004036_abnormal_muscle_relaxation1.18145994
88MP0001348_abnormal_lacrimal_gland1.17496067
89MP0005369_muscle_phenotype1.15203449
90MP0002075_abnormal_coat/hair_pigmentati1.14920278
91MP0000537_abnormal_urethra_morphology1.14776201
92MP0001968_abnormal_touch/_nociception1.14482492
93MP0004133_heterotaxia1.14316644
94MP0000609_abnormal_liver_physiology1.14269942
95MP0004947_skin_inflammation1.14187390
96MP0004885_abnormal_endolymph1.10209789
97MP0001873_stomach_inflammation1.10092060
98MP0000631_abnormal_neuroendocrine_gland1.09083568
99MP0005075_abnormal_melanosome_morpholog1.08997683
100MP0001666_abnormal_nutrient_absorption1.08512439
101MP0009745_abnormal_behavioral_response1.08024493
102MP0008569_lethality_at_weaning1.07305900
103MP0003045_fibrosis1.05933993
104MP0003136_yellow_coat_color1.04824295
105MP0003635_abnormal_synaptic_transmissio1.04542160
106MP0002557_abnormal_social/conspecific_i1.04266113
107MP0000858_altered_metastatic_potential1.02857837
108MP0004142_abnormal_muscle_tone1.01463543
109MP0000685_abnormal_immune_system0.99900275
110MP0000778_abnormal_nervous_system0.98988555
111MP0002064_seizures0.98224799
112MP0002796_impaired_skin_barrier0.96919517
113MP0002971_abnormal_brown_adipose0.96207351
114MP0003111_abnormal_nucleus_morphology0.95882194
115MP0000371_diluted_coat_color0.95411402
116MP0008058_abnormal_DNA_repair0.94424711
117MP0005310_abnormal_salivary_gland0.93072928
118MP0004859_abnormal_synaptic_plasticity0.92901998
119MP0001186_pigmentation_phenotype0.92730914
120MP0010155_abnormal_intestine_physiology0.92532934
121MP0003566_abnormal_cell_adhesion0.91965937
122MP0002067_abnormal_sensory_capabilities0.91779729
123MP0002572_abnormal_emotion/affect_behav0.91317009
124MP0005670_abnormal_white_adipose0.89580553
125MP0005083_abnormal_biliary_tract0.89089582
126MP0002006_tumorigenesis0.87333902
127MP0003315_abnormal_perineum_morphology0.85074358
128MP0000465_gastrointestinal_hemorrhage0.84209001
129MP0002398_abnormal_bone_marrow0.83942368
130MP0000598_abnormal_liver_morphology0.83671601
131MP0000490_abnormal_crypts_of0.83264156
132MP0002249_abnormal_larynx_morphology0.82970227
133MP0003183_abnormal_peptide_metabolism0.82610353
134MP0002118_abnormal_lipid_homeostasis0.82604781
135MP0003300_gastrointestinal_ulcer0.82423600
136MP0003656_abnormal_erythrocyte_physiolo0.82209510
137MP0002277_abnormal_respiratory_mucosa0.81578582
138MP0003828_pulmonary_edema0.81217502
139MP0003984_embryonic_growth_retardation0.81121830
140MP0003943_abnormal_hepatobiliary_system0.80892912
141MP0001800_abnormal_humoral_immune0.80638625
142MP0006138_congestive_heart_failure0.80256954
143MP0001835_abnormal_antigen_presentation0.79947009
144MP0002272_abnormal_nervous_system0.79873167
145MP0003880_abnormal_central_pattern0.79121732
146MP0001177_atelectasis0.78607389
147MP0002086_abnormal_extraembryonic_tissu0.78297724
148MP0004742_abnormal_vestibular_system0.78139056
149MP0000750_abnormal_muscle_regeneration0.77793372
150MP0005387_immune_system_phenotype0.77678512
151MP0001790_abnormal_immune_system0.77678512
152MP0002638_abnormal_pupillary_reflex0.77529757
153MP0001915_intracranial_hemorrhage0.76911779
154MP0002088_abnormal_embryonic_growth/wei0.76570128
155MP0000477_abnormal_intestine_morphology0.76535211
156MP0004510_myositis0.76156352
157MP0005025_abnormal_response_to0.76006230
158MP0002177_abnormal_outer_ear0.75988343
159MP0000689_abnormal_spleen_morphology0.75930327
160MP0002970_abnormal_white_adipose0.74560589
161MP0000428_abnormal_craniofacial_morphol0.74463423
162MP0000026_abnormal_inner_ear0.73228656
163MP0000678_abnormal_parathyroid_gland0.73178748
164MP0009115_abnormal_fat_cell0.72994714
165MP0003329_amyloid_beta_deposits0.72713134
166MP0009931_abnormal_skin_appearance0.71926270
167MP0000716_abnormal_immune_system0.71913679
168MP0002080_prenatal_lethality0.70858994
169MP0002420_abnormal_adaptive_immunity0.70599087
170MP0009780_abnormal_chondrocyte_physiolo0.69684864
171MP0002722_abnormal_immune_system0.69371182
172MP0002877_abnormal_melanocyte_morpholog0.69094306
173MP0003115_abnormal_respiratory_system0.68871191
174MP0002078_abnormal_glucose_homeostasis0.68860163
175MP0005621_abnormal_cell_physiology0.68779363
176MP0002419_abnormal_innate_immunity0.67927778
177MP0002098_abnormal_vibrissa_morphology0.67318406
178MP0001819_abnormal_immune_cell0.65951700
179MP0000955_abnormal_spinal_cord0.65600357
180MP0003861_abnormal_nervous_system0.65110226
181MP0002152_abnormal_brain_morphology0.62434323
182MP0002127_abnormal_cardiovascular_syste0.61731667

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.26315055
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.14823477
3Chromsome breakage (HP:0040012)4.50863815
4Panhypogammaglobulinemia (HP:0003139)4.49062047
5Deep venous thrombosis (HP:0002625)4.34169915
6Myopathic facies (HP:0002058)4.12014541
7Muscle fiber inclusion bodies (HP:0100299)3.96386399
8Nemaline bodies (HP:0003798)3.91117967
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.76641670
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.76339929
11Stomach cancer (HP:0012126)3.74332192
12Duplicated collecting system (HP:0000081)3.71044940
13Abnormality of the renal collecting system (HP:0004742)3.57939287
14Reticulocytopenia (HP:0001896)3.56196506
15Abnormality of the fingertips (HP:0001211)3.34288123
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.30212886
17Hemorrhage of the eye (HP:0011885)3.20399454
18Obstructive sleep apnea (HP:0002870)3.14328457
19Oligodactyly (hands) (HP:0001180)2.99523818
20Chronic otitis media (HP:0000389)2.84062068
21Generalized hypopigmentation of hair (HP:0011358)2.80121201
22Abnormality of skeletal muscle fiber size (HP:0012084)2.78088994
23Ectopic kidney (HP:0000086)2.77684587
24Increased connective tissue (HP:0009025)2.76402030
25Intestinal atresia (HP:0011100)2.76357149
26Abnormality of the nasal septum (HP:0000419)2.73881539
27Type 1 muscle fiber predominance (HP:0003803)2.71944048
28Supernumerary ribs (HP:0005815)2.64755627
29Flat acetabular roof (HP:0003180)2.61033757
30Progressive muscle weakness (HP:0003323)2.60504888
31Joint hemorrhage (HP:0005261)2.59866689
32Duplication of thumb phalanx (HP:0009942)2.58339650
33Increased variability in muscle fiber diameter (HP:0003557)2.58086277
34Rhabdomyolysis (HP:0003201)2.56242390
35Abnormal number of incisors (HP:0011064)2.54493961
36Distal lower limb muscle weakness (HP:0009053)2.53788386
37Long eyelashes (HP:0000527)2.51857718
38Acute lymphatic leukemia (HP:0006721)2.51297335
39Ulnar deviation of the wrist (HP:0003049)2.51281587
40Thyroid-stimulating hormone excess (HP:0002925)2.50035315
41Supernumerary bones of the axial skeleton (HP:0009144)2.49016260
42Depressed nasal tip (HP:0000437)2.46594084
43Eczematoid dermatitis (HP:0000976)2.44976377
44Colitis (HP:0002583)2.43264066
45Distal lower limb amyotrophy (HP:0008944)2.42493158
46Esophageal atresia (HP:0002032)2.39108988
47Anal stenosis (HP:0002025)2.38487635
48Broad face (HP:0000283)2.37792318
49Asymmetric septal hypertrophy (HP:0001670)2.36132887
50Abnormality of DNA repair (HP:0003254)2.34315151
51EMG: myopathic abnormalities (HP:0003458)2.31920564
52Abnormality of the axillary hair (HP:0100134)2.31155655
53Abnormality of secondary sexual hair (HP:0009888)2.31155655
54Inflammation of the large intestine (HP:0002037)2.31094313
55Bulbar palsy (HP:0001283)2.30015221
56Trigonocephaly (HP:0000243)2.29726042
57Cerebral aneurysm (HP:0004944)2.28354632
58Medulloblastoma (HP:0002885)2.28086793
59Stridor (HP:0010307)2.26666235
60Ulnar bowing (HP:0003031)2.26634832
61Clubbing of toes (HP:0100760)2.25865753
62Obsessive-compulsive behavior (HP:0000722)2.25466012
63Abnormality of binocular vision (HP:0011514)2.24783428
64Diplopia (HP:0000651)2.24783428
65Easy fatigability (HP:0003388)2.24707070
66Thin bony cortex (HP:0002753)2.24362168
67Recurrent cutaneous fungal infections (HP:0011370)2.23221559
68Chronic mucocutaneous candidiasis (HP:0002728)2.23221559
69Prolonged partial thromboplastin time (HP:0003645)2.23115752
70Focal motor seizures (HP:0011153)2.22369439
71Anophthalmia (HP:0000528)2.21387020
72Asymmetry of the thorax (HP:0001555)2.20912867
73Volvulus (HP:0002580)2.19717218
74Split foot (HP:0001839)2.18532554
75Spinal cord lesions (HP:0100561)2.16339892
76Syringomyelia (HP:0003396)2.16339892
77Oligodactyly (HP:0012165)2.14589235
78Exercise-induced muscle cramps (HP:0003710)2.12813523
79Round ear (HP:0100830)2.12172857
80Ragged-red muscle fibers (HP:0003200)2.11492506
81Hyperacusis (HP:0010780)2.11319034
82Abnormality of the Achilles tendon (HP:0005109)2.09834325
83Neoplasm of the tracheobronchial system (HP:0100552)2.09631273
84Difficulty running (HP:0009046)2.08989684
85Septo-optic dysplasia (HP:0100842)2.08889622
86Meckel diverticulum (HP:0002245)2.08325146
87Muscle stiffness (HP:0003552)2.07515895
88Gastrointestinal inflammation (HP:0004386)2.07049436
89Abnormality of the parietal bone (HP:0002696)2.06593323
90Reticulocytosis (HP:0001923)2.06335029
91Gastroesophageal reflux (HP:0002020)2.04886487
9211 pairs of ribs (HP:0000878)2.04782928
93J-shaped sella turcica (HP:0002680)2.04096542
94Partial duplication of thumb phalanx (HP:0009944)2.04010673
95Overfolded helix (HP:0000396)2.03916899
96Seborrheic dermatitis (HP:0001051)2.03518508
97Hyporeflexia of lower limbs (HP:0002600)2.03365579
98Mediastinal lymphadenopathy (HP:0100721)2.02536614
99Sleep apnea (HP:0010535)2.02449788
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02137690
101Urethral obstruction (HP:0000796)2.01149308
102Testicular neoplasm (HP:0010788)2.00374244
103Myoglobinuria (HP:0002913)2.00151493
104Hypercholesterolemia (HP:0003124)1.99651014
105Prolonged bleeding time (HP:0003010)1.99552955
106Stenosis of the external auditory canal (HP:0000402)1.99364258
107Germ cell neoplasia (HP:0100728)1.98434663
108Bowel incontinence (HP:0002607)1.98297983
109Dysmetric saccades (HP:0000641)1.98013836
110Viral hepatitis (HP:0006562)1.97862840
111Xanthomatosis (HP:0000991)1.97480387
112Achilles tendon contracture (HP:0001771)1.96331850
113Gastrointestinal atresia (HP:0002589)1.95368539
114Dislocated radial head (HP:0003083)1.94753761
115Abnormality of pyrimidine metabolism (HP:0004353)1.93343943
116Embryonal neoplasm (HP:0002898)1.92629523
117Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92070829
118Short 4th metacarpal (HP:0010044)1.92070829
119Mildly elevated creatine phosphokinase (HP:0008180)1.91943763
120Neck muscle weakness (HP:0000467)1.91665743
121Abnormality of the ileum (HP:0001549)1.91077860
122Annular pancreas (HP:0001734)1.90477737
123Abnormality of the preputium (HP:0100587)1.89215887
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88939753
125Arnold-Chiari malformation (HP:0002308)1.88154915
126Ocular albinism (HP:0001107)1.87741085
127Abnormally folded helix (HP:0008544)1.87668995
128Muscle hypertrophy of the lower extremities (HP:0008968)1.87224002
129Agammaglobulinemia (HP:0004432)1.86446952
130Abnormality of the thoracic spine (HP:0100711)1.85637742
131Febrile seizures (HP:0002373)1.83251983
132Malignant hyperthermia (HP:0002047)1.81526013
133Narrow palate (HP:0000189)1.80362428
134Abnormality of chromosome stability (HP:0003220)1.80189932
135Distal arthrogryposis (HP:0005684)1.79352805
136Recurrent viral infections (HP:0004429)1.79348842
137Abnormality of the radial head (HP:0003995)1.79119540
138Abnormality of chromosome segregation (HP:0002916)1.79049211
139Aqueductal stenosis (HP:0002410)1.78796978
140Deformed sella turcica (HP:0002681)1.78738962
141Abnormality of the common coagulation pathway (HP:0010990)1.78377135
142Abnormal large intestine physiology (HP:0012700)1.78234029
143Progressive external ophthalmoplegia (HP:0000590)1.77430140
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.77168866
145Cellulitis (HP:0100658)1.77121337
146Muscle fiber splitting (HP:0003555)1.74411267
147Meningitis (HP:0001287)1.74088946
148Broad-based gait (HP:0002136)1.72875740
149Aplastic anemia (HP:0001915)1.72695345
150Disproportionate tall stature (HP:0001519)1.72397961
151EMG: neuropathic changes (HP:0003445)1.72309180
152Subaortic stenosis (HP:0001682)1.71859571
153Abnormality of the left ventricular outflow tract (HP:0011103)1.71859571
154Metaphyseal cupping (HP:0003021)1.69915487
155Hypercortisolism (HP:0001578)1.68451953
156Hypobetalipoproteinemia (HP:0003563)1.67677001
157Flat occiput (HP:0005469)1.65708190
158Hyperkalemia (HP:0002153)1.65625311
159Skull defect (HP:0001362)1.65390238
160Lip pit (HP:0100267)1.64369186
161Diaphragmatic weakness (HP:0009113)1.64002893
162Abnormality of the carotid arteries (HP:0005344)1.63525975
1632-3 toe syndactyly (HP:0004691)1.62101257
164Slow saccadic eye movements (HP:0000514)1.62039549
165Triphalangeal thumb (HP:0001199)1.60439408
166Thin ribs (HP:0000883)1.58845799
167Obstructive lung disease (HP:0006536)1.57975378
168Chronic obstructive pulmonary disease (HP:0006510)1.57975378
169Ankle clonus (HP:0011448)1.57113258
170Abnormality of the duodenum (HP:0002246)1.56807884
171Abnormality of the phalanges of the 2nd finger (HP:0009541)1.56775421
172Renal agenesis (HP:0000104)1.56768205
173Abnormality of the antihelix (HP:0009738)1.56718360
174Partial duplication of the phalanx of hand (HP:0009999)1.56571469
175Rectal prolapse (HP:0002035)1.56483338
176Recurrent fungal infections (HP:0002841)1.55117168
177Heterotopia (HP:0002282)1.53743899
178Micronodular cirrhosis (HP:0001413)1.51901617
179Increased serum ferritin (HP:0003281)1.51890012
180Thoracic kyphosis (HP:0002942)1.50649086
181Ventricular tachycardia (HP:0004756)1.50467005
182Abnormality of complement system (HP:0005339)1.50390833
183Calf muscle hypertrophy (HP:0008981)1.49680573
184Gastrointestinal infarctions (HP:0005244)1.49303390
185Increased IgE level (HP:0003212)1.48896692
186Aneurysm (HP:0002617)1.48659442
187Hypophosphatemia (HP:0002148)1.48573211
188Lower limb amyotrophy (HP:0007210)1.48432015
189Abnormality of the calcaneus (HP:0008364)1.47822652
190Difficulty climbing stairs (HP:0003551)1.46771053
191Abnormality of the distal phalanx of the thumb (HP:0009617)1.46186570
192Back pain (HP:0003418)1.45545022
193Bronchomalacia (HP:0002780)1.44998048
194External ophthalmoplegia (HP:0000544)1.43939881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.62957511
2SMG13.35355466
3SIK13.35258886
4ERN13.28509566
5TNIK3.00248653
6FGFR42.95564632
7MAP3K62.66509140
8SIK22.42786503
9EEF2K2.39405212
10BRD42.31404567
11CDK122.21080220
12TTN2.17450168
13CAMK1G2.04607588
14MKNK21.97183410
15STK161.92718541
16CDK31.91405494
17CAMK1D1.78567977
18FES1.73404050
19RIPK11.72037102
20CLK11.69331457
21PRPF4B1.68899959
22OBSCN1.68256180
23GRK71.67134898
24CDK91.66758815
25TYK21.64133071
26MAP3K101.54793740
27PKN21.50319363
28FGFR31.47570610
29EPHA21.45928641
30TGFBR21.44362631
31IRAK41.41049249
32MARK21.37707418
33MAP3K71.36947196
34YES11.36824163
35MAP2K71.36801568
36TAOK11.36409813
37TNK21.36173421
38MAP3K131.33707584
39CDK61.27983304
40TXK1.27780487
41MAP3K41.27474643
42MAP4K11.26743675
43TRPM71.17004208
44SRPK11.16859375
45GRK61.16088451
46MAP3K11.15122313
47MTOR1.13688223
48NEK61.13156175
49KSR21.12830622
50EPHB11.11633971
51MAP2K31.10339460
52ALK1.08149221
53MKNK11.07777626
54CDK41.07370826
55PHKG11.07206159
56PHKG21.07206159
57MAP2K41.06666233
58CDK71.04324030
59MAPKAPK51.04151951
60ATR1.03205367
61BTK1.02407965
62RPS6KB20.98724623
63VRK10.98596749
64ZAP700.98345249
65RIPK40.97880906
66MAPK120.96609726
67SGK20.95268637
68FGFR20.94723152
69HIPK20.93422543
70ADRBK20.93283966
71PDPK10.93136191
72CAMK40.90040324
73CDC70.89835032
74HCK0.89294359
75EIF2AK20.89035629
76MUSK0.87510179
77MAP3K30.87502621
78MAP2K60.87214624
79DYRK1B0.85709665
80MAP2K20.85382783
81CDC42BPA0.85181863
82CAMK10.84221653
83SGK30.81892042
84NTRK20.81583594
85PRKD20.79407531
86MAP3K50.79355750
87TYRO30.78997399
88SIK30.78645660
89NLK0.77584494
90MAPK150.77544218
91UHMK10.77405002
92MAP3K140.76560630
93PNCK0.75181638
94IRAK20.74658484
95MAPKAPK30.74608986
96RPS6KA20.74079158
97PDGFRA0.73326695
98TEC0.72631608
99JAK10.71191368
100RET0.70298608
101ICK0.70105484
102ZAK0.70018405
103MAP3K110.69941832
104PDK10.69483629
105NTRK30.69018716
106TAOK20.67352262
107TBK10.67263954
108RPS6KL10.67253110
109RPS6KC10.67253110
110LCK0.66491695
111CSNK1A1L0.65653696
112CHUK0.64353642
113KIT0.63749893
114STK380.61506019
115CSK0.61203034
116PRKAA20.59274145
117MAPK110.58958564
118IKBKB0.58880901
119IRAK30.58575017
120MST1R0.58462693
121PASK0.58344689
122MAPK130.57923930
123PDGFRB0.57030306
124SGK4940.55534085
125SGK2230.55534085
126IKBKE0.54296466
127MAP3K20.54236006
128SCYL20.54061043
129PRKAA10.53830117
130MAPK140.53348643
131BMX0.52621884
132PTK60.52087011
133STK110.51376442
134RPS6KB10.51011304
135PRKD30.50926076
136MAPK40.50585318
137STK240.50211484
138ERBB20.49328238
139JAK20.48691253
140CAMKK10.48095269
141PRKCH0.47946096
142FGR0.47342409
143BLK0.47034049
144RPS6KA10.46100952
145RPS6KA60.45730796
146MAPK100.44571132
147PKN10.43530973
148PAK40.43195276
149NME10.43065606
150TESK20.42973555
151GSK3B0.41897264
152SGK10.41580616
153ITK0.40944473
154MAP3K80.40567663
155CDK20.40136253
156PRKDC0.38992553
157CSNK1G10.38880325
158CSNK1D0.38765664
159LRRK20.38374896
160CSF1R0.36263118
161LMTK20.34756640

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.83260004
2Nicotine addiction_Homo sapiens_hsa050332.36218589
3Other glycan degradation_Homo sapiens_hsa005112.30584381
4Non-homologous end-joining_Homo sapiens_hsa034502.25096532
5Lysine degradation_Homo sapiens_hsa003102.23642411
6Basal cell carcinoma_Homo sapiens_hsa052172.01448495
7Fructose and mannose metabolism_Homo sapiens_hsa000512.00363247
8Insulin signaling pathway_Homo sapiens_hsa049101.84370030
9Insulin resistance_Homo sapiens_hsa049311.82730662
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79718023
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77803742
12Pentose phosphate pathway_Homo sapiens_hsa000301.73957045
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73078028
14Endometrial cancer_Homo sapiens_hsa052131.71084121
15Primary immunodeficiency_Homo sapiens_hsa053401.66385052
16Glutamatergic synapse_Homo sapiens_hsa047241.62460668
17Thyroid cancer_Homo sapiens_hsa052161.62435486
18ABC transporters_Homo sapiens_hsa020101.59395237
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57692977
20DNA replication_Homo sapiens_hsa030301.56488639
21VEGF signaling pathway_Homo sapiens_hsa043701.56026088
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.54183909
23mTOR signaling pathway_Homo sapiens_hsa041501.53916322
24Morphine addiction_Homo sapiens_hsa050321.51153479
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.48065898
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45773147
27Fanconi anemia pathway_Homo sapiens_hsa034601.45050135
28Pancreatic cancer_Homo sapiens_hsa052121.44808387
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44783767
30Arginine biosynthesis_Homo sapiens_hsa002201.44041407
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43789705
32AMPK signaling pathway_Homo sapiens_hsa041521.43675900
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39984016
34Glucagon signaling pathway_Homo sapiens_hsa049221.35873307
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32297615
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.31528294
37Wnt signaling pathway_Homo sapiens_hsa043101.29447975
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26610786
39cAMP signaling pathway_Homo sapiens_hsa040241.24730595
40Taste transduction_Homo sapiens_hsa047421.24581923
41Olfactory transduction_Homo sapiens_hsa047401.23963677
42Complement and coagulation cascades_Homo sapiens_hsa046101.23624042
43Galactose metabolism_Homo sapiens_hsa000521.23488132
44Dorso-ventral axis formation_Homo sapiens_hsa043201.23337471
45Staphylococcus aureus infection_Homo sapiens_hsa051501.21935779
46Biosynthesis of amino acids_Homo sapiens_hsa012301.21659797
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21607992
48Renal cell carcinoma_Homo sapiens_hsa052111.17935468
49Phenylalanine metabolism_Homo sapiens_hsa003601.15538392
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14084520
51Osteoclast differentiation_Homo sapiens_hsa043801.13816358
52Calcium signaling pathway_Homo sapiens_hsa040201.11149017
53Cocaine addiction_Homo sapiens_hsa050301.11075465
54B cell receptor signaling pathway_Homo sapiens_hsa046621.09588655
55Circadian entrainment_Homo sapiens_hsa047131.09036262
56Salivary secretion_Homo sapiens_hsa049701.08899527
57Inositol phosphate metabolism_Homo sapiens_hsa005621.06748821
58Herpes simplex infection_Homo sapiens_hsa051681.05850370
59Choline metabolism in cancer_Homo sapiens_hsa052311.03216224
60GABAergic synapse_Homo sapiens_hsa047271.03092101
61Hepatitis C_Homo sapiens_hsa051601.02519797
62Axon guidance_Homo sapiens_hsa043601.01684204
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01366183
64Bladder cancer_Homo sapiens_hsa052191.01194750
65Chemokine signaling pathway_Homo sapiens_hsa040621.00400070
66Melanogenesis_Homo sapiens_hsa049160.98245449
67Long-term depression_Homo sapiens_hsa047300.98192240
68Glioma_Homo sapiens_hsa052140.96240955
69Carbon metabolism_Homo sapiens_hsa012000.95813139
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92702199
71FoxO signaling pathway_Homo sapiens_hsa040680.92676971
72MicroRNAs in cancer_Homo sapiens_hsa052060.92618800
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92609359
74Colorectal cancer_Homo sapiens_hsa052100.92042787
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91486746
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91482911
77Gastric acid secretion_Homo sapiens_hsa049710.90848535
78Hedgehog signaling pathway_Homo sapiens_hsa043400.90727268
79Base excision repair_Homo sapiens_hsa034100.90557388
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90003193
81Spliceosome_Homo sapiens_hsa030400.89584339
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88854259
83Bile secretion_Homo sapiens_hsa049760.88590266
84Leishmaniasis_Homo sapiens_hsa051400.88193064
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86658477
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86501510
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.85852534
88Chronic myeloid leukemia_Homo sapiens_hsa052200.85655423
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85577926
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85529798
91Long-term potentiation_Homo sapiens_hsa047200.84651933
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84148508
93Measles_Homo sapiens_hsa051620.83671864
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83532923
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.81919430
96T cell receptor signaling pathway_Homo sapiens_hsa046600.81780468
97Vitamin digestion and absorption_Homo sapiens_hsa049770.81605549
98Serotonergic synapse_Homo sapiens_hsa047260.80125519
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80083237
100Prion diseases_Homo sapiens_hsa050200.80064943
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78015250
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77459887
103Mismatch repair_Homo sapiens_hsa034300.76427772
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76415887
105mRNA surveillance pathway_Homo sapiens_hsa030150.76314329
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.75438359
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.75388958
108Fatty acid biosynthesis_Homo sapiens_hsa000610.74481822
109Influenza A_Homo sapiens_hsa051640.74305932
110HTLV-I infection_Homo sapiens_hsa051660.74029324
111Acute myeloid leukemia_Homo sapiens_hsa052210.73667905
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73540407
113MAPK signaling pathway_Homo sapiens_hsa040100.73240814
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.72354032
115Sulfur relay system_Homo sapiens_hsa041220.71863854
116Homologous recombination_Homo sapiens_hsa034400.71748133
117Renin secretion_Homo sapiens_hsa049240.71713848
118Non-small cell lung cancer_Homo sapiens_hsa052230.71618212
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70913976
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70214850
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.69977367
122Amphetamine addiction_Homo sapiens_hsa050310.69722851
123Starch and sucrose metabolism_Homo sapiens_hsa005000.68914948
124Pertussis_Homo sapiens_hsa051330.68148363
125Insulin secretion_Homo sapiens_hsa049110.67539368
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67511423
127Type II diabetes mellitus_Homo sapiens_hsa049300.66958313
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.65971566
129Prostate cancer_Homo sapiens_hsa052150.65882245
130Pathways in cancer_Homo sapiens_hsa052000.65726187
131Viral carcinogenesis_Homo sapiens_hsa052030.64375710
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64164253
133Hepatitis B_Homo sapiens_hsa051610.63252852
134Platelet activation_Homo sapiens_hsa046110.61779977
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61553884
136Arginine and proline metabolism_Homo sapiens_hsa003300.61153130
137Small cell lung cancer_Homo sapiens_hsa052220.60911994
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60434213
139HIF-1 signaling pathway_Homo sapiens_hsa040660.60289007
140Fatty acid metabolism_Homo sapiens_hsa012120.60139798
141Dopaminergic synapse_Homo sapiens_hsa047280.58734042
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.56876926
143Estrogen signaling pathway_Homo sapiens_hsa049150.56319190
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56257614
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55770019
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55618152
147GnRH signaling pathway_Homo sapiens_hsa049120.55355936
148PPAR signaling pathway_Homo sapiens_hsa033200.55261712
149RNA polymerase_Homo sapiens_hsa030200.55189753
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.55125468
151Apoptosis_Homo sapiens_hsa042100.54461802
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52873589
153Prolactin signaling pathway_Homo sapiens_hsa049170.52460413
154Cholinergic synapse_Homo sapiens_hsa047250.52344242
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51805317
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50182625
157ErbB signaling pathway_Homo sapiens_hsa040120.49684136
158Cyanoamino acid metabolism_Homo sapiens_hsa004600.49128343
159Cell cycle_Homo sapiens_hsa041100.48913447
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48722181
161Fatty acid degradation_Homo sapiens_hsa000710.48434941
162Toxoplasmosis_Homo sapiens_hsa051450.48373549
163N-Glycan biosynthesis_Homo sapiens_hsa005100.47012532
164Fat digestion and absorption_Homo sapiens_hsa049750.44026774
165Endocytosis_Homo sapiens_hsa041440.43546583

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