

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.86196551 |
| 2 | nuclear pore organization (GO:0006999) | 6.52500664 |
| 3 | mitotic sister chromatid cohesion (GO:0007064) | 5.59924574 |
| 4 | pore complex assembly (GO:0046931) | 5.11967746 |
| 5 | pre-miRNA processing (GO:0031054) | 4.82214328 |
| 6 | regulation of histone H3-K9 methylation (GO:0051570) | 4.53949688 |
| 7 | regulation of RNA export from nucleus (GO:0046831) | 4.48644464 |
| 8 | DNA unwinding involved in DNA replication (GO:0006268) | 4.36419283 |
| 9 | mitotic nuclear envelope disassembly (GO:0007077) | 4.35152388 |
| 10 | protein localization to kinetochore (GO:0034501) | 4.33516199 |
| 11 | negative regulation of histone methylation (GO:0031061) | 4.24094618 |
| 12 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.21853984 |
| 13 | mitotic chromosome condensation (GO:0007076) | 4.19057770 |
| 14 | heterochromatin organization (GO:0070828) | 4.15111014 |
| 15 | nuclear envelope disassembly (GO:0051081) | 4.12568677 |
| 16 | membrane disassembly (GO:0030397) | 4.12568677 |
| 17 | negative regulation of DNA repair (GO:0045738) | 4.09147677 |
| 18 | sister chromatid segregation (GO:0000819) | 4.04848310 |
| 19 | protein localization to chromosome, centromeric region (GO:0071459) | 3.93840427 |
| 20 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.82032412 |
| 21 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.82032412 |
| 22 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.81017051 |
| 23 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.81017051 |
| 24 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.81017051 |
| 25 | DNA duplex unwinding (GO:0032508) | 3.79856611 |
| 26 | regulation of histone H3-K27 methylation (GO:0061085) | 3.79092013 |
| 27 | DNA geometric change (GO:0032392) | 3.78924640 |
| 28 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.77645533 |
| 29 | regulation of centriole replication (GO:0046599) | 3.77586567 |
| 30 | regulation of sister chromatid cohesion (GO:0007063) | 3.73287299 |
| 31 | mitotic sister chromatid segregation (GO:0000070) | 3.69912152 |
| 32 | chromatin assembly (GO:0031497) | 3.67921813 |
| 33 | histone H3-K36 demethylation (GO:0070544) | 3.60729531 |
| 34 | positive regulation of chromosome segregation (GO:0051984) | 3.59340950 |
| 35 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.56223297 |
| 36 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.54520426 |
| 37 | regulation of spindle organization (GO:0090224) | 3.51065253 |
| 38 | * gene silencing by RNA (GO:0031047) | 3.50521241 |
| 39 | protein export from nucleus (GO:0006611) | 3.49283039 |
| 40 | NLS-bearing protein import into nucleus (GO:0006607) | 3.48451070 |
| 41 | dosage compensation (GO:0007549) | 3.48371895 |
| 42 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.45628805 |
| 43 | regulation of translational fidelity (GO:0006450) | 3.44276897 |
| 44 | COPI coating of Golgi vesicle (GO:0048205) | 3.41525309 |
| 45 | Golgi transport vesicle coating (GO:0048200) | 3.41525309 |
| 46 | regulation of DNA endoreduplication (GO:0032875) | 3.37262506 |
| 47 | DNA strand elongation (GO:0022616) | 3.36568192 |
| 48 | RNA stabilization (GO:0043489) | 3.34433544 |
| 49 | mRNA stabilization (GO:0048255) | 3.34433544 |
| 50 | translesion synthesis (GO:0019985) | 3.34333598 |
| 51 | synaptonemal complex assembly (GO:0007130) | 3.32167874 |
| 52 | chromosome condensation (GO:0030261) | 3.31921985 |
| 53 | sister chromatid cohesion (GO:0007062) | 3.31437959 |
| 54 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.30683995 |
| 55 | regulation of mitotic spindle organization (GO:0060236) | 3.27705923 |
| 56 | peptidyl-lysine dimethylation (GO:0018027) | 3.27468781 |
| 57 | DNA conformation change (GO:0071103) | 3.26382674 |
| 58 | mitotic metaphase plate congression (GO:0007080) | 3.25430015 |
| 59 | nuclear envelope organization (GO:0006998) | 3.24408144 |
| 60 | regulation of gene silencing by RNA (GO:0060966) | 3.24260196 |
| 61 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.24260196 |
| 62 | regulation of gene silencing by miRNA (GO:0060964) | 3.24260196 |
| 63 | histone H2A monoubiquitination (GO:0035518) | 3.22921005 |
| 64 | metaphase plate congression (GO:0051310) | 3.19435688 |
| 65 | DNA packaging (GO:0006323) | 3.17185159 |
| 66 | regulation of centrosome cycle (GO:0046605) | 3.14936663 |
| 67 | embryonic process involved in female pregnancy (GO:0060136) | 3.14190503 |
| 68 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.13724207 |
| 69 | protein localization to chromosome (GO:0034502) | 3.13055423 |
| 70 | * gene silencing (GO:0016458) | 3.12883478 |
| 71 | regulation of chromosome segregation (GO:0051983) | 3.10258191 |
| 72 | DNA synthesis involved in DNA repair (GO:0000731) | 3.10010010 |
| 73 | piRNA metabolic process (GO:0034587) | 3.09646312 |
| 74 | meiotic chromosome segregation (GO:0045132) | 3.08533752 |
| 75 | chromatin assembly or disassembly (GO:0006333) | 3.05266610 |
| 76 | kinetochore organization (GO:0051383) | 3.03479573 |
| 77 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.02469081 |
| 78 | negative regulation of histone modification (GO:0031057) | 3.02409251 |
| 79 | synaptonemal complex organization (GO:0070193) | 3.00506548 |
| 80 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.00212472 |
| 81 | regulation of protein polyubiquitination (GO:1902914) | 2.99706690 |
| 82 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.97866032 |
| 83 | spindle assembly involved in mitosis (GO:0090307) | 2.97462358 |
| 84 | positive regulation of transcription from RNA polymerase III promoter (GO:0045945) | 2.95797316 |
| 85 | histone H3-K9 methylation (GO:0051567) | 2.94926918 |
| 86 | cellular protein complex localization (GO:0034629) | 2.92797229 |
| 87 | paraxial mesoderm development (GO:0048339) | 2.91547067 |
| 88 | protein-DNA complex disassembly (GO:0032986) | 2.91325525 |
| 89 | nucleosome disassembly (GO:0006337) | 2.91325525 |
| 90 | negative regulation of chromatin modification (GO:1903309) | 2.90359213 |
| 91 | non-recombinational repair (GO:0000726) | 2.90103375 |
| 92 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.90103375 |
| 93 | regulation of centrosome duplication (GO:0010824) | 2.89634160 |
| 94 | mRNA transport (GO:0051028) | 2.89418928 |
| 95 | IMP biosynthetic process (GO:0006188) | 2.88497898 |
| 96 | regulation of translational termination (GO:0006449) | 2.88310519 |
| 97 | protein complex localization (GO:0031503) | 2.87682307 |
| 98 | ATP-dependent chromatin remodeling (GO:0043044) | 2.87570321 |
| 99 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.86405016 |
| 100 | male meiosis (GO:0007140) | 2.84987231 |
| 101 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.84187246 |
| 102 | DNA replication initiation (GO:0006270) | 2.84018348 |
| 103 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.83415892 |
| 104 | microtubule cytoskeleton organization involved in mitosis (GO:1902850) | 2.82864670 |
| 105 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.82809676 |
| 106 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.82329982 |
| 107 | response to epidermal growth factor (GO:0070849) | 2.82188783 |
| 108 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.81236531 |
| 109 | chaperone-mediated protein complex assembly (GO:0051131) | 2.80260049 |
| 110 | regulation of histone methylation (GO:0031060) | 2.78464426 |
| 111 | establishment of chromosome localization (GO:0051303) | 2.78419753 |
| 112 | V(D)J recombination (GO:0033151) | 2.76791325 |
| 113 | formation of translation preinitiation complex (GO:0001731) | 2.76297761 |
| 114 | cellular response to epidermal growth factor stimulus (GO:0071364) | 2.75614597 |
| 115 | chromosome organization involved in meiosis (GO:0070192) | 2.75363936 |
| 116 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.74626038 |
| 117 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.74249636 |
| 118 | COPII vesicle coating (GO:0048208) | 2.73837361 |
| 119 | regulation of DNA damage checkpoint (GO:2000001) | 2.73738169 |
| 120 | histone lysine demethylation (GO:0070076) | 2.72901668 |
| 121 | regulation of mRNA stability (GO:0043488) | 2.72365070 |
| 122 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.72234374 |
| 123 | chromosome segregation (GO:0007059) | 2.71548459 |
| 124 | DNA topological change (GO:0006265) | 2.69672567 |
| 125 | regulation of sister chromatid segregation (GO:0033045) | 2.69579734 |
| 126 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.69579734 |
| 127 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.69579734 |
| 128 | regulation of helicase activity (GO:0051095) | 2.69389003 |
| 129 | regulation of histone H3-K4 methylation (GO:0051569) | 2.63362205 |
| 130 | histone H3-K9 demethylation (GO:0033169) | 2.62583376 |
| 131 | cellular hyperosmotic response (GO:0071474) | 2.62353778 |
| 132 | corticosteroid receptor signaling pathway (GO:0031958) | 2.59079456 |
| 133 | nucleus organization (GO:0006997) | 2.56309608 |
| 134 | histone demethylation (GO:0016577) | 2.55453151 |
| 135 | mitotic recombination (GO:0006312) | 2.55119461 |
| 136 | telomere maintenance via recombination (GO:0000722) | 2.55021520 |
| 137 | negative regulation of mRNA metabolic process (GO:1903312) | 2.49532294 |
| 138 | nucleic acid transport (GO:0050657) | 2.48130734 |
| 139 | RNA transport (GO:0050658) | 2.48130734 |
| 140 | establishment of RNA localization (GO:0051236) | 2.48130734 |
| 141 | positive regulation of protein import into nucleus, translocation (GO:0033160) | 2.43997826 |
| 142 | proline biosynthetic process (GO:0006561) | 2.43987498 |
| 143 | peptidyl-threonine phosphorylation (GO:0018107) | 2.41890263 |
| 144 | peptidyl-threonine modification (GO:0018210) | 2.41585719 |
| 145 | activation of Rac GTPase activity (GO:0032863) | 2.41213208 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.05174360 |
| 2 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.07841739 |
| 3 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.88694863 |
| 4 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 3.87060028 |
| 5 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.20490117 |
| 6 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.18883249 |
| 7 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.94920194 |
| 8 | MYC_22102868_ChIP-Seq_BL_Human | 2.70044270 |
| 9 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.58939298 |
| 10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.55381826 |
| 11 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.41357176 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.41159761 |
| 13 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.14679401 |
| 14 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.11173760 |
| 15 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.3409385 |
| 16 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.99248587 |
| 17 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.88278271 |
| 18 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.85251647 |
| 19 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.77588606 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.77161669 |
| 21 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.75542296 |
| 22 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.74215820 |
| 23 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.72455218 |
| 24 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.67518643 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.64456467 |
| 26 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.61271088 |
| 27 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.56063776 |
| 28 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.53664447 |
| 29 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.50503689 |
| 30 | * CIITA_25753668_ChIP-Seq_RAJI_Human | 1.44192496 |
| 31 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.43179272 |
| 32 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.41929629 |
| 33 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.39216291 |
| 34 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.34450230 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.33776162 |
| 36 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.33428575 |
| 37 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.33094358 |
| 38 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.32304219 |
| 39 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.32174152 |
| 40 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.31815651 |
| 41 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.31605357 |
| 42 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.30767181 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.30638422 |
| 44 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.29153508 |
| 45 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.28563296 |
| 46 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.28413396 |
| 47 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.27652546 |
| 48 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.27367247 |
| 49 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.25326034 |
| 50 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.23310980 |
| 51 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.23063361 |
| 52 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.21597182 |
| 53 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.20941290 |
| 54 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.20185628 |
| 55 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.18489642 |
| 56 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.15867644 |
| 57 | GATA1_22025678_ChIP-Seq_K562_Human | 1.14684650 |
| 58 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.13190002 |
| 59 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.12340593 |
| 60 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.11736835 |
| 61 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.11584407 |
| 62 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.10480069 |
| 63 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.10480069 |
| 64 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.10480069 |
| 65 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 1.09440166 |
| 66 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.09130090 |
| 67 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.07993931 |
| 68 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.06601351 |
| 69 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05656841 |
| 70 | MYB_26560356_Chip-Seq_TH1_Human | 1.05225003 |
| 71 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.05039577 |
| 72 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.04000780 |
| 73 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.03579728 |
| 74 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.02479089 |
| 75 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.02270473 |
| 76 | UTX_26944678_Chip-Seq_JUKART_Human | 1.01930940 |
| 77 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.01512164 |
| 78 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.01067338 |
| 79 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.00931496 |
| 80 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.99528594 |
| 81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99208586 |
| 82 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.99081780 |
| 83 | * FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.98961231 |
| 84 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.98498568 |
| 85 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.97833131 |
| 86 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97549963 |
| 87 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.96343009 |
| 88 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.96259292 |
| 89 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.96051031 |
| 90 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.96026783 |
| 91 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.96019048 |
| 92 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95498873 |
| 93 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.94867433 |
| 94 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.94242389 |
| 95 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.93730854 |
| 96 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.93517944 |
| 97 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.92960056 |
| 98 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.92914358 |
| 99 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 0.92391251 |
| 100 | MYB_26560356_Chip-Seq_TH2_Human | 0.92116735 |
| 101 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91884633 |
| 102 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.91840008 |
| 103 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.91566154 |
| 104 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.91250470 |
| 105 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.90915356 |
| 106 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.89852424 |
| 107 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89618269 |
| 108 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.89417835 |
| 109 | * ATF3_27146783_Chip-Seq_COLON_Human | 0.88554273 |
| 110 | MAF_26560356_Chip-Seq_TH1_Human | 0.88423975 |
| 111 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.88205362 |
| 112 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.88098615 |
| 113 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.87259945 |
| 114 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.86673226 |
| 115 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86325762 |
| 116 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.86214229 |
| 117 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.86120575 |
| 118 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.84683484 |
| 119 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.84400261 |
| 120 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.82971680 |
| 121 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.81993440 |
| 122 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.81545639 |
| 123 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.81470413 |
| 124 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.81279809 |
| 125 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.80739247 |
| 126 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.80577597 |
| 127 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.79062308 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 3.61473507 |
| 2 | MP0008057_abnormal_DNA_replication | 3.45812450 |
| 3 | MP0010352_gastrointestinal_tract_polyps | 3.21417547 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.18742311 |
| 5 | MP0008877_abnormal_DNA_methylation | 2.97120400 |
| 6 | MP0003077_abnormal_cell_cycle | 2.91157748 |
| 7 | MP0005076_abnormal_cell_differentiation | 2.79035477 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.76040191 |
| 9 | MP0003693_abnormal_embryo_hatching | 2.71337165 |
| 10 | MP0010307_abnormal_tumor_latency | 2.68043793 |
| 11 | MP0003705_abnormal_hypodermis_morpholog | 2.58412644 |
| 12 | MP0001730_embryonic_growth_arrest | 2.32989381 |
| 13 | MP0003123_paternal_imprinting | 2.29281679 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.08609383 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.03343005 |
| 16 | MP0004197_abnormal_fetal_growth/weight/ | 1.99295549 |
| 17 | MP0005380_embryogenesis_phenotype | 1.99073251 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.99073251 |
| 19 | MP0005451_abnormal_body_composition | 1.98666798 |
| 20 | MP0008058_abnormal_DNA_repair | 1.97497766 |
| 21 | MP0000569_abnormal_digit_pigmentation | 1.96658039 |
| 22 | MP0002084_abnormal_developmental_patter | 1.93148651 |
| 23 | MP0003984_embryonic_growth_retardation | 1.90481545 |
| 24 | MP0002088_abnormal_embryonic_growth/wei | 1.88666254 |
| 25 | MP0003121_genomic_imprinting | 1.84275799 |
| 26 | MP0010234_abnormal_vibrissa_follicle | 1.84039189 |
| 27 | MP0002086_abnormal_extraembryonic_tissu | 1.83206597 |
| 28 | MP0001697_abnormal_embryo_size | 1.77806486 |
| 29 | MP0004808_abnormal_hematopoietic_stem | 1.72943112 |
| 30 | MP0005409_darkened_coat_color | 1.70762862 |
| 31 | MP0003890_abnormal_embryonic-extraembry | 1.69607147 |
| 32 | MP0002085_abnormal_embryonic_tissue | 1.68917320 |
| 33 | MP0002396_abnormal_hematopoietic_system | 1.65293504 |
| 34 | MP0005410_abnormal_fertilization | 1.61211170 |
| 35 | MP0000537_abnormal_urethra_morphology | 1.55733884 |
| 36 | MP0001293_anophthalmia | 1.52790375 |
| 37 | MP0002080_prenatal_lethality | 1.50622073 |
| 38 | MP0001929_abnormal_gametogenesis | 1.48140661 |
| 39 | MP0009053_abnormal_anal_canal | 1.46502972 |
| 40 | MP0002210_abnormal_sex_determination | 1.43702285 |
| 41 | MP0003567_abnormal_fetal_cardiomyocyte | 1.42874617 |
| 42 | MP0009278_abnormal_bone_marrow | 1.41227157 |
| 43 | MP0001849_ear_inflammation | 1.38527773 |
| 44 | MP0009697_abnormal_copulation | 1.35799821 |
| 45 | MP0009703_decreased_birth_body | 1.35106152 |
| 46 | MP0002796_impaired_skin_barrier | 1.35102292 |
| 47 | MP0009672_abnormal_birth_weight | 1.34965997 |
| 48 | MP0003566_abnormal_cell_adhesion | 1.33232314 |
| 49 | MP0004264_abnormal_extraembryonic_tissu | 1.33191050 |
| 50 | MP0008932_abnormal_embryonic_tissue | 1.33034700 |
| 51 | MP0001661_extended_life_span | 1.29286707 |
| 52 | MP0001145_abnormal_male_reproductive | 1.28413209 |
| 53 | MP0005623_abnormal_meninges_morphology | 1.26597500 |
| 54 | MP0003453_abnormal_keratinocyte_physiol | 1.25258106 |
| 55 | MP0000733_abnormal_muscle_development | 1.24729240 |
| 56 | MP0003300_gastrointestinal_ulcer | 1.14764458 |
| 57 | MP0003698_abnormal_male_reproductive | 1.13301454 |
| 58 | MP0003786_premature_aging | 1.13180173 |
| 59 | MP0001915_intracranial_hemorrhage | 1.12521190 |
| 60 | MP0002092_abnormal_eye_morphology | 1.12234357 |
| 61 | MP0003115_abnormal_respiratory_system | 1.12099027 |
| 62 | MP0002653_abnormal_ependyma_morphology | 1.12011032 |
| 63 | MP0000428_abnormal_craniofacial_morphol | 1.09406584 |
| 64 | MP0010030_abnormal_orbit_morphology | 1.08896575 |
| 65 | MP0002877_abnormal_melanocyte_morpholog | 1.08024885 |
| 66 | MP0000653_abnormal_sex_gland | 1.06680571 |
| 67 | MP0002925_abnormal_cardiovascular_devel | 1.05714292 |
| 68 | MP0000313_abnormal_cell_death | 1.05081664 |
| 69 | MP0005501_abnormal_skin_physiology | 1.04988138 |
| 70 | MP0003787_abnormal_imprinting | 1.04177276 |
| 71 | MP0001545_abnormal_hematopoietic_system | 1.03251794 |
| 72 | MP0005397_hematopoietic_system_phenotyp | 1.03251794 |
| 73 | MP0003119_abnormal_digestive_system | 1.03037533 |
| 74 | MP0003943_abnormal_hepatobiliary_system | 1.02134566 |
| 75 | MP0006054_spinal_hemorrhage | 1.01780336 |
| 76 | MP0004233_abnormal_muscle_weight | 1.01307289 |
| 77 | MP0003935_abnormal_craniofacial_develop | 1.00539480 |
| 78 | MP0000703_abnormal_thymus_morphology | 1.00016965 |
| 79 | MP0005023_abnormal_wound_healing | 0.99731208 |
| 80 | MP0002019_abnormal_tumor_incidence | 0.98595145 |
| 81 | MP0003937_abnormal_limbs/digits/tail_de | 0.98030926 |
| 82 | MP0005666_abnormal_adipose_tissue | 0.96419040 |
| 83 | MP0002697_abnormal_eye_size | 0.95089568 |
| 84 | MP0003221_abnormal_cardiomyocyte_apopto | 0.93827570 |
| 85 | MP0002166_altered_tumor_susceptibility | 0.93702161 |
| 86 | MP0000432_abnormal_head_morphology | 0.92357055 |
| 87 | MP0001216_abnormal_epidermal_layer | 0.92211065 |
| 88 | MP0000490_abnormal_crypts_of | 0.91903647 |
| 89 | MP0000377_abnormal_hair_follicle | 0.89654843 |
| 90 | MP0005187_abnormal_penis_morphology | 0.86511066 |
| 91 | MP0004185_abnormal_adipocyte_glucose | 0.85205568 |
| 92 | MP0002098_abnormal_vibrissa_morphology | 0.84128588 |
| 93 | MP0002060_abnormal_skin_morphology | 0.83174508 |
| 94 | MP0010630_abnormal_cardiac_muscle | 0.83076412 |
| 95 | MP0000566_synostosis | 0.82895469 |
| 96 | MP0000266_abnormal_heart_morphology | 0.81208375 |
| 97 | MP0003656_abnormal_erythrocyte_physiolo | 0.80931023 |
| 98 | MP0000627_abnormal_mammary_gland | 0.77484106 |
| 99 | MP0008260_abnormal_autophagy | 0.77461323 |
| 100 | MP0000858_altered_metastatic_potential | 0.77343097 |
| 101 | MP0004947_skin_inflammation | 0.76547994 |
| 102 | MP0000477_abnormal_intestine_morphology | 0.75904746 |
| 103 | MP0005621_abnormal_cell_physiology | 0.75196810 |
| 104 | MP0002161_abnormal_fertility/fecundity | 0.74665371 |
| 105 | MP0010678_abnormal_skin_adnexa | 0.74293889 |
| 106 | MP0000383_abnormal_hair_follicle | 0.73392198 |
| 107 | MP0001346_abnormal_lacrimal_gland | 0.73383640 |
| 108 | MP0003763_abnormal_thymus_physiology | 0.73279402 |
| 109 | MP0002006_tumorigenesis | 0.73097583 |
| 110 | MP0004782_abnormal_surfactant_physiolog | 0.70935500 |
| 111 | MP0000371_diluted_coat_color | 0.70654996 |
| 112 | MP0005384_cellular_phenotype | 0.69534605 |
| 113 | MP0002111_abnormal_tail_morphology | 0.69278499 |
| 114 | MP0001873_stomach_inflammation | 0.69210250 |
| 115 | MP0002398_abnormal_bone_marrow | 0.69046559 |
| 116 | MP0002009_preneoplasia | 0.68786094 |
| 117 | MP0005367_renal/urinary_system_phenotyp | 0.68157750 |
| 118 | MP0000516_abnormal_urinary_system | 0.68157750 |
| 119 | MP0008770_decreased_survivor_rate | 0.65760209 |
| 120 | MP0001784_abnormal_fluid_regulation | 0.65757574 |
| 121 | MP0002722_abnormal_immune_system | 0.65700499 |
| 122 | MP0003091_abnormal_cell_migration | 0.65664873 |
| 123 | MP0001286_abnormal_eye_development | 0.65404744 |
| 124 | MP0004272_abnormal_basement_membrane | 0.65092418 |
| 125 | MP0003861_abnormal_nervous_system | 0.63912803 |
| 126 | MP0002160_abnormal_reproductive_system | 0.62937878 |
| 127 | MP0009931_abnormal_skin_appearance | 0.62397479 |
| 128 | MP0004381_abnormal_hair_follicle | 0.62116640 |
| 129 | MP0005375_adipose_tissue_phenotype | 0.61844795 |
| 130 | MP0005408_hypopigmentation | 0.61577491 |
| 131 | MP0003941_abnormal_skin_development | 0.60310859 |
| 132 | MP0002089_abnormal_postnatal_growth/wei | 0.60267343 |
| 133 | MP0003868_abnormal_feces_composition | 0.60236364 |
| 134 | MP0000003_abnormal_adipose_tissue | 0.58408581 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 3.73064868 |
| 2 | Ependymoma (HP:0002888) | 3.53696426 |
| 3 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.39814752 |
| 4 | Short 4th metacarpal (HP:0010044) | 3.39814752 |
| 5 | Increased nuchal translucency (HP:0010880) | 3.10545529 |
| 6 | Ankyloglossia (HP:0010296) | 3.08504216 |
| 7 | Astrocytoma (HP:0009592) | 3.00960208 |
| 8 | Abnormality of the astrocytes (HP:0100707) | 3.00960208 |
| 9 | Abnormality of the fingertips (HP:0001211) | 2.96782836 |
| 10 | Medulloblastoma (HP:0002885) | 2.93933536 |
| 11 | Selective tooth agenesis (HP:0001592) | 2.92143747 |
| 12 | Deviation of the thumb (HP:0009603) | 2.80224370 |
| 13 | Heterotopia (HP:0002282) | 2.75963451 |
| 14 | Impulsivity (HP:0100710) | 2.75907347 |
| 15 | Proximal placement of thumb (HP:0009623) | 2.75347661 |
| 16 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.73693673 |
| 17 | Flat acetabular roof (HP:0003180) | 2.73244159 |
| 18 | Long eyelashes (HP:0000527) | 2.72003588 |
| 19 | Colon cancer (HP:0003003) | 2.68895513 |
| 20 | Ectopic kidney (HP:0000086) | 2.66099921 |
| 21 | Dysmetric saccades (HP:0000641) | 2.62082684 |
| 22 | Neoplasm of the oral cavity (HP:0100649) | 2.59275344 |
| 23 | Asymmetry of the thorax (HP:0001555) | 2.58793683 |
| 24 | Abnormality of oral frenula (HP:0000190) | 2.56269124 |
| 25 | Glioma (HP:0009733) | 2.52923682 |
| 26 | Embryonal renal neoplasm (HP:0011794) | 2.51061981 |
| 27 | Abnormality of the 4th metacarpal (HP:0010012) | 2.50829647 |
| 28 | Biliary tract neoplasm (HP:0100574) | 2.50424903 |
| 29 | Prominent nose (HP:0000448) | 2.49716031 |
| 30 | Rhabdomyosarcoma (HP:0002859) | 2.48552744 |
| 31 | Chromsome breakage (HP:0040012) | 2.47467808 |
| 32 | Abnormality of the lower motor neuron (HP:0002366) | 2.47244285 |
| 33 | Hyperacusis (HP:0010780) | 2.43972365 |
| 34 | Renovascular hypertension (HP:0100817) | 2.34895384 |
| 35 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.34592191 |
| 36 | Truncal obesity (HP:0001956) | 2.33830866 |
| 37 | Neoplasm of striated muscle (HP:0009728) | 2.28739311 |
| 38 | Absent frontal sinuses (HP:0002688) | 2.27411342 |
| 39 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.25767388 |
| 40 | Gastrointestinal carcinoma (HP:0002672) | 2.25767388 |
| 41 | Sandal gap (HP:0001852) | 2.21117750 |
| 42 | Leiomyosarcoma (HP:0100243) | 2.20469957 |
| 43 | Uterine leiomyosarcoma (HP:0002891) | 2.20469957 |
| 44 | High pitched voice (HP:0001620) | 2.18623014 |
| 45 | Renal duplication (HP:0000075) | 2.18441597 |
| 46 | Abnormality of chromosome stability (HP:0003220) | 2.15442929 |
| 47 | Missing ribs (HP:0000921) | 2.14432592 |
| 48 | Skull defect (HP:0001362) | 2.13712795 |
| 49 | Supernumerary ribs (HP:0005815) | 2.13364203 |
| 50 | Termporal pattern (HP:0011008) | 2.12554143 |
| 51 | Insidious onset (HP:0003587) | 2.12554143 |
| 52 | Rectal prolapse (HP:0002035) | 2.12522066 |
| 53 | Trigonocephaly (HP:0000243) | 2.11698916 |
| 54 | Papillary thyroid carcinoma (HP:0002895) | 2.09564281 |
| 55 | Subacute progressive viral hepatitis (HP:0006572) | 2.09435281 |
| 56 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.09127163 |
| 57 | Basal cell carcinoma (HP:0002671) | 2.08228387 |
| 58 | Urethral obstruction (HP:0000796) | 2.07833910 |
| 59 | Low anterior hairline (HP:0000294) | 2.07686772 |
| 60 | Deep philtrum (HP:0002002) | 2.03799071 |
| 61 | Abnormality of the anterior horn cell (HP:0006802) | 2.03397491 |
| 62 | Degeneration of anterior horn cells (HP:0002398) | 2.03397491 |
| 63 | Progressive external ophthalmoplegia (HP:0000590) | 2.03334148 |
| 64 | Cortical dysplasia (HP:0002539) | 2.02942525 |
| 65 | Macroorchidism (HP:0000053) | 2.02759720 |
| 66 | Abnormal foot bone ossification (HP:0010675) | 2.02382350 |
| 67 | Relative macrocephaly (HP:0004482) | 2.01593083 |
| 68 | Transitional cell carcinoma of the bladder (HP:0006740) | 2.01519472 |
| 69 | Abnormality of the salivary glands (HP:0010286) | 2.01207930 |
| 70 | Cutis marmorata (HP:0000965) | 1.99802801 |
| 71 | Abnormality of the labia minora (HP:0012880) | 1.97502899 |
| 72 | Abnormality of chromosome segregation (HP:0002916) | 1.96764600 |
| 73 | Pseudobulbar signs (HP:0002200) | 1.95218337 |
| 74 | Narrow palate (HP:0000189) | 1.94935760 |
| 75 | Obsessive-compulsive behavior (HP:0000722) | 1.94605475 |
| 76 | Hypopigmentation of the fundus (HP:0007894) | 1.93879657 |
| 77 | Broad thumb (HP:0011304) | 1.93328732 |
| 78 | Cafe-au-lait spot (HP:0000957) | 1.92451190 |
| 79 | Agnosia (HP:0010524) | 1.92409578 |
| 80 | Broad face (HP:0000283) | 1.91996003 |
| 81 | Short humerus (HP:0005792) | 1.91541761 |
| 82 | 11 pairs of ribs (HP:0000878) | 1.91145186 |
| 83 | Hypoplastic labia majora (HP:0000059) | 1.90383362 |
| 84 | Broad palm (HP:0001169) | 1.90303245 |
| 85 | Neonatal hypoglycemia (HP:0001998) | 1.90085920 |
| 86 | Elfin facies (HP:0004428) | 1.88473593 |
| 87 | Bladder carcinoma (HP:0002862) | 1.88272231 |
| 88 | Bladder neoplasm (HP:0009725) | 1.88272231 |
| 89 | Advanced eruption of teeth (HP:0006288) | 1.87443793 |
| 90 | Vertebral arch anomaly (HP:0008438) | 1.87318838 |
| 91 | Acute myeloid leukemia (HP:0004808) | 1.86817216 |
| 92 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.84633025 |
| 93 | Embryonal neoplasm (HP:0002898) | 1.83791228 |
| 94 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.83304543 |
| 95 | Right ventricular cardiomyopathy (HP:0011663) | 1.79952284 |
| 96 | Viral hepatitis (HP:0006562) | 1.79853640 |
| 97 | Abnormality of the carotid arteries (HP:0005344) | 1.79546958 |
| 98 | Cerebral aneurysm (HP:0004944) | 1.77375265 |
| 99 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.77323080 |
| 100 | Skin tags (HP:0010609) | 1.75373081 |
| 101 | Septate vagina (HP:0001153) | 1.75112918 |
| 102 | Ankle contracture (HP:0006466) | 1.74924258 |
| 103 | Bowel diverticulosis (HP:0005222) | 1.74801415 |
| 104 | High anterior hairline (HP:0009890) | 1.74100771 |
| 105 | Facial hemangioma (HP:0000329) | 1.73896218 |
| 106 | Hepatoblastoma (HP:0002884) | 1.73883714 |
| 107 | Cutaneous melanoma (HP:0012056) | 1.73349935 |
| 108 | Sparse lateral eyebrow (HP:0005338) | 1.72736224 |
| 109 | Abnormality of the calcaneus (HP:0008364) | 1.72614182 |
| 110 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.72445677 |
| 111 | Broad phalanges of the hand (HP:0009768) | 1.72424001 |
| 112 | Uterine neoplasm (HP:0010784) | 1.72337627 |
| 113 | Overlapping toe (HP:0001845) | 1.72173359 |
| 114 | Spinal cord lesions (HP:0100561) | 1.71824795 |
| 115 | Syringomyelia (HP:0003396) | 1.71824795 |
| 116 | Deep palmar crease (HP:0006191) | 1.71522863 |
| 117 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.71246105 |
| 118 | Disproportionate tall stature (HP:0001519) | 1.71100152 |
| 119 | Ovarian neoplasm (HP:0100615) | 1.70644465 |
| 120 | Atresia of the external auditory canal (HP:0000413) | 1.70552157 |
| 121 | Insomnia (HP:0100785) | 1.70097530 |
| 122 | Metaphyseal cupping (HP:0003021) | 1.70015818 |
| 123 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.69488916 |
| 124 | Osteolytic defects of the hand bones (HP:0009699) | 1.69488916 |
| 125 | Limited elbow extension (HP:0001377) | 1.68477478 |
| 126 | Dislocated radial head (HP:0003083) | 1.68396933 |
| 127 | Renal cell carcinoma (HP:0005584) | 1.68387868 |
| 128 | Shallow orbits (HP:0000586) | 1.68370965 |
| 129 | Germ cell neoplasia (HP:0100728) | 1.68170303 |
| 130 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.67513542 |
| 131 | Myelodysplasia (HP:0002863) | 1.67202144 |
| 132 | Abnormality of the labia majora (HP:0012881) | 1.66920276 |
| 133 | Anal stenosis (HP:0002025) | 1.65742762 |
| 134 | Abnormality of the diencephalon (HP:0010662) | 1.65156556 |
| 135 | Colitis (HP:0002583) | 1.64693791 |
| 136 | Breast carcinoma (HP:0003002) | 1.64200700 |
| 137 | Abnormal number of incisors (HP:0011064) | 1.63907765 |
| 138 | Neoplasm of the small intestine (HP:0100833) | 1.63717215 |
| 139 | Sloping forehead (HP:0000340) | 1.62445147 |
| 140 | Fibrous tissue neoplasm (HP:0012316) | 1.61694717 |
| 141 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.61216648 |
| 142 | Bicuspid aortic valve (HP:0001647) | 1.60628865 |
| 143 | Persistence of primary teeth (HP:0006335) | 1.58592171 |
| 144 | Poikiloderma (HP:0001029) | 1.56766617 |
| 145 | Birth length less than 3rd percentile (HP:0003561) | 1.56218435 |
| 146 | Abnormality of the radial head (HP:0003995) | 1.55888805 |
| 147 | Long palpebral fissure (HP:0000637) | 1.55351563 |
| 148 | Diastasis recti (HP:0001540) | 1.53197654 |
| 149 | Capillary hemangiomas (HP:0005306) | 1.52194346 |
| 150 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.51186441 |
| 151 | Arnold-Chiari malformation (HP:0002308) | 1.50742967 |
| 152 | Ulnar bowing (HP:0003031) | 1.50550295 |
| 153 | Abnormality of the preputium (HP:0100587) | 1.50034576 |
| 154 | Abnormality of the thoracic spine (HP:0100711) | 1.49973163 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 5.00501817 |
| 2 | CDC7 | 3.91835275 |
| 3 | SMG1 | 3.36517686 |
| 4 | EEF2K | 3.23619081 |
| 5 | NEK2 | 2.99993571 |
| 6 | PKN2 | 2.49445123 |
| 7 | MAP3K10 | 2.43623971 |
| 8 | LATS1 | 2.33800089 |
| 9 | BRD4 | 2.22864368 |
| 10 | PRPF4B | 2.20210989 |
| 11 | WEE1 | 2.16919029 |
| 12 | PDK3 | 2.12223763 |
| 13 | PDK4 | 2.12223763 |
| 14 | TTK | 1.98212949 |
| 15 | PASK | 1.74009228 |
| 16 | ATR | 1.67628933 |
| 17 | STK3 | 1.65954514 |
| 18 | STK10 | 1.60917888 |
| 19 | CAMK1D | 1.58910590 |
| 20 | MST1R | 1.58877914 |
| 21 | ICK | 1.54329833 |
| 22 | RPS6KB2 | 1.52578820 |
| 23 | SCYL2 | 1.52367070 |
| 24 | CDK4 | 1.52241123 |
| 25 | CDK6 | 1.50340278 |
| 26 | TRIB3 | 1.50226230 |
| 27 | MTOR | 1.49037346 |
| 28 | TSSK6 | 1.48586519 |
| 29 | NEK1 | 1.45816830 |
| 30 | CHEK1 | 1.44323716 |
| 31 | KSR2 | 1.35478966 |
| 32 | PNCK | 1.35261002 |
| 33 | BRSK2 | 1.35070935 |
| 34 | CAMK1G | 1.30458385 |
| 35 | PLK1 | 1.27103343 |
| 36 | CHEK2 | 1.21934018 |
| 37 | CDK7 | 1.21532796 |
| 38 | ATM | 1.20807123 |
| 39 | PTK6 | 1.19149743 |
| 40 | ALK | 1.17298446 |
| 41 | PLK3 | 1.16030771 |
| 42 | AURKB | 1.15207845 |
| 43 | TTN | 1.15014315 |
| 44 | STK4 | 1.14471740 |
| 45 | PBK | 1.12622230 |
| 46 | MAP3K8 | 1.10467938 |
| 47 | FLT3 | 1.07238404 |
| 48 | MAP3K2 | 1.06925203 |
| 49 | SRPK1 | 1.05964419 |
| 50 | RIPK1 | 1.05675970 |
| 51 | PDGFRA | 1.02610733 |
| 52 | PDK2 | 1.00729926 |
| 53 | MKNK1 | 0.99532220 |
| 54 | FGFR3 | 0.98579246 |
| 55 | FGFR1 | 0.98148436 |
| 56 | RPS6KA4 | 0.97061261 |
| 57 | TAF1 | 0.96932858 |
| 58 | YES1 | 0.96524389 |
| 59 | CDK2 | 0.94717391 |
| 60 | MAP3K14 | 0.94303933 |
| 61 | TGFBR1 | 0.92757546 |
| 62 | CDK8 | 0.92673441 |
| 63 | PRKD3 | 0.92616497 |
| 64 | PAK4 | 0.91182945 |
| 65 | MELK | 0.90757819 |
| 66 | IRAK3 | 0.89446702 |
| 67 | EPHA2 | 0.86154876 |
| 68 | CDK9 | 0.85687763 |
| 69 | NEK9 | 0.83228545 |
| 70 | BUB1 | 0.80471283 |
| 71 | MAP3K13 | 0.80133451 |
| 72 | CLK1 | 0.76172543 |
| 73 | ACVR1B | 0.75450813 |
| 74 | SIK1 | 0.73302503 |
| 75 | PIM1 | 0.73035171 |
| 76 | MAP4K1 | 0.72999276 |
| 77 | MAPK11 | 0.72886311 |
| 78 | CDK1 | 0.71950398 |
| 79 | FGFR2 | 0.70835205 |
| 80 | PAK2 | 0.70136571 |
| 81 | CSNK1D | 0.69349707 |
| 82 | EIF2AK3 | 0.69290309 |
| 83 | TESK1 | 0.69163376 |
| 84 | KSR1 | 0.68763735 |
| 85 | MKNK2 | 0.66819668 |
| 86 | PDGFRB | 0.66580857 |
| 87 | MARK3 | 0.65221059 |
| 88 | LRRK2 | 0.64102020 |
| 89 | TYRO3 | 0.63571424 |
| 90 | PLK4 | 0.62220521 |
| 91 | RET | 0.61348157 |
| 92 | BMX | 0.60113334 |
| 93 | AKT3 | 0.58661956 |
| 94 | PRKDC | 0.58617408 |
| 95 | RAF1 | 0.56536702 |
| 96 | ERN1 | 0.53747189 |
| 97 | NLK | 0.53428925 |
| 98 | NEK6 | 0.52679341 |
| 99 | DYRK3 | 0.51907579 |
| 100 | RIPK4 | 0.50754457 |
| 101 | MAPK14 | 0.50483596 |
| 102 | STK24 | 0.50306866 |
| 103 | CSNK1E | 0.47617955 |
| 104 | RPS6KB1 | 0.46748110 |
| 105 | MET | 0.46668761 |
| 106 | BRSK1 | 0.46542413 |
| 107 | MAP3K9 | 0.46173436 |
| 108 | STK38L | 0.45625237 |
| 109 | FRK | 0.45601315 |
| 110 | TRPM7 | 0.45404640 |
| 111 | MAPK1 | 0.43693400 |
| 112 | FGFR4 | 0.43428907 |
| 113 | ERBB4 | 0.42488454 |
| 114 | JAK3 | 0.42211954 |
| 115 | WNK1 | 0.40358754 |
| 116 | CHUK | 0.40148934 |
| 117 | CDC42BPA | 0.40076624 |
| 118 | EIF2AK1 | 0.39838990 |
| 119 | BRAF | 0.39379847 |
| 120 | GSK3B | 0.38680292 |
| 121 | AKT2 | 0.37593176 |
| 122 | MAPK10 | 0.37476247 |
| 123 | JAK1 | 0.36691916 |
| 124 | AKT1 | 0.36665440 |
| 125 | BTK | 0.36071143 |
| 126 | LATS2 | 0.35468559 |
| 127 | SGK3 | 0.34506659 |
| 128 | CSNK2A2 | 0.34039230 |
| 129 | MAP2K3 | 0.30439859 |
| 130 | STK38 | 0.29612780 |
| 131 | RPS6KA1 | 0.28732601 |
| 132 | CSF1R | 0.28510848 |
| 133 | DYRK1B | 0.28496640 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RNA transport_Homo sapiens_hsa03013 | 2.95492844 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 2.93012954 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 2.76368365 |
| 4 | Cell cycle_Homo sapiens_hsa04110 | 2.76346410 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.42933186 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.41364444 |
| 7 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.39551092 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.25979184 |
| 9 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.97069755 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.94543943 |
| 11 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.90056572 |
| 12 | Lysine degradation_Homo sapiens_hsa00310 | 1.86742907 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 1.80367221 |
| 14 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.68506109 |
| 15 | Homologous recombination_Homo sapiens_hsa03440 | 1.62998039 |
| 16 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.60710270 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.58429403 |
| 18 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.58383809 |
| 19 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.57221969 |
| 20 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.52592436 |
| 21 | Adherens junction_Homo sapiens_hsa04520 | 1.50763465 |
| 22 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.49985449 |
| 23 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.45532857 |
| 24 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.41474742 |
| 25 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.36940115 |
| 26 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.36921602 |
| 27 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.35971511 |
| 28 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.31495788 |
| 29 | * RNA degradation_Homo sapiens_hsa03018 | 1.30372869 |
| 30 | HTLV-I infection_Homo sapiens_hsa05166 | 1.29599710 |
| 31 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.24048306 |
| 32 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.21133265 |
| 33 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.20577581 |
| 34 | Basal transcription factors_Homo sapiens_hsa03022 | 1.16287090 |
| 35 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.13308562 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.12097725 |
| 37 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.08960074 |
| 38 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.07634018 |
| 39 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.06971892 |
| 40 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.06638459 |
| 41 | Colorectal cancer_Homo sapiens_hsa05210 | 1.04676003 |
| 42 | Thyroid cancer_Homo sapiens_hsa05216 | 1.03368865 |
| 43 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.02612943 |
| 44 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.00664112 |
| 45 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.99908781 |
| 46 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.97797675 |
| 47 | Endometrial cancer_Homo sapiens_hsa05213 | 0.95537218 |
| 48 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.95047784 |
| 49 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.94379679 |
| 50 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.94126206 |
| 51 | Viral myocarditis_Homo sapiens_hsa05416 | 0.92168003 |
| 52 | Prostate cancer_Homo sapiens_hsa05215 | 0.91686283 |
| 53 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.88977445 |
| 54 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.86444703 |
| 55 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.85571135 |
| 56 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.83318095 |
| 57 | Hepatitis C_Homo sapiens_hsa05160 | 0.81184906 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.81012132 |
| 59 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.79787364 |
| 60 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.75949181 |
| 61 | Hepatitis B_Homo sapiens_hsa05161 | 0.72814938 |
| 62 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.72578151 |
| 63 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.71790946 |
| 64 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.71314681 |
| 65 | Insulin resistance_Homo sapiens_hsa04931 | 0.70613861 |
| 66 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.70351893 |
| 67 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.69306988 |
| 68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.68865081 |
| 69 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.68722757 |
| 70 | Pathways in cancer_Homo sapiens_hsa05200 | 0.68323959 |
| 71 | Focal adhesion_Homo sapiens_hsa04510 | 0.68314343 |
| 72 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.66786510 |
| 73 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.65689748 |
| 74 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.65581764 |
| 75 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.64524781 |
| 76 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.64159244 |
| 77 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.62828451 |
| 78 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.62805704 |
| 79 | Alcoholism_Homo sapiens_hsa05034 | 0.61386971 |
| 80 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.61104045 |
| 81 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.60650436 |
| 82 | Tight junction_Homo sapiens_hsa04530 | 0.58965352 |
| 83 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.58642589 |
| 84 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.58468424 |
| 85 | Influenza A_Homo sapiens_hsa05164 | 0.58236086 |
| 86 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57010393 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.54934061 |
| 88 | Measles_Homo sapiens_hsa05162 | 0.54851673 |
| 89 | Glioma_Homo sapiens_hsa05214 | 0.54822292 |
| 90 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.54072614 |
| 91 | Melanoma_Homo sapiens_hsa05218 | 0.53474019 |
| 92 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.51724253 |
| 93 | Bladder cancer_Homo sapiens_hsa05219 | 0.51622651 |
| 94 | Legionellosis_Homo sapiens_hsa05134 | 0.50532164 |
| 95 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.49449079 |
| 96 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.48932309 |
| 97 | Apoptosis_Homo sapiens_hsa04210 | 0.48817503 |
| 98 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.48480104 |
| 99 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.47623032 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.47379833 |
| 101 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.46196591 |
| 102 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.45309733 |
| 103 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.45232916 |
| 104 | Carbon metabolism_Homo sapiens_hsa01200 | 0.44844519 |
| 105 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.44424616 |
| 106 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.43963943 |
| 107 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.43413685 |
| 108 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.42978551 |
| 109 | Other glycan degradation_Homo sapiens_hsa00511 | 0.42238875 |
| 110 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.41495428 |
| 111 | Shigellosis_Homo sapiens_hsa05131 | 0.41267110 |
| 112 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.40831218 |
| 113 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.39887203 |
| 114 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39104582 |
| 115 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.38678835 |
| 116 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.37620148 |

