CNOT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.98140199
2DNA unwinding involved in DNA replication (GO:0006268)4.96573772
3nuclear pore organization (GO:0006999)4.95399271
4folic acid-containing compound biosynthetic process (GO:0009396)4.84619922
5mitotic nuclear envelope disassembly (GO:0007077)4.53899877
6protein localization to kinetochore (GO:0034501)4.50181322
7nuclear envelope disassembly (GO:0051081)4.30680438
8membrane disassembly (GO:0030397)4.30680438
9mitotic chromosome condensation (GO:0007076)4.24662059
10pre-miRNA processing (GO:0031054)4.07413843
11heterochromatin organization (GO:0070828)3.86902080
12protein localization to chromosome, centromeric region (GO:0071459)3.86826469
13histone H2A monoubiquitination (GO:0035518)3.84815283
14dosage compensation (GO:0007549)3.84438747
15regulation of translational fidelity (GO:0006450)3.82824426
16DNA replication-dependent nucleosome assembly (GO:0006335)3.76223953
17DNA replication-dependent nucleosome organization (GO:0034723)3.76223953
18DNA replication initiation (GO:0006270)3.69671267
19regulation of translational termination (GO:0006449)3.68841975
20regulation of sister chromatid cohesion (GO:0007063)3.67971511
21regulation of gene silencing by RNA (GO:0060966)3.64501006
22regulation of posttranscriptional gene silencing (GO:0060147)3.64501006
23regulation of gene silencing by miRNA (GO:0060964)3.64501006
24DNA duplex unwinding (GO:0032508)3.59224499
25nuclear envelope organization (GO:0006998)3.57544951
26DNA geometric change (GO:0032392)3.56969944
27negative regulation of histone methylation (GO:0031061)3.55171756
28mitotic metaphase plate congression (GO:0007080)3.53291185
29pinocytosis (GO:0006907)3.52143575
30regulation of DNA methylation (GO:0044030)3.51870720
31DNA strand elongation involved in DNA replication (GO:0006271)3.51686960
32mitotic sister chromatid cohesion (GO:0007064)3.50310246
33regulation of RNA export from nucleus (GO:0046831)3.49065302
34pore complex assembly (GO:0046931)3.46962198
35proline biosynthetic process (GO:0006561)3.46425938
36sister chromatid segregation (GO:0000819)3.43079671
37positive regulation of chromosome segregation (GO:0051984)3.42202204
38mitotic sister chromatid segregation (GO:0000070)3.41792666
39plasma lipoprotein particle assembly (GO:0034377)3.38715681
40chromatin assembly (GO:0031497)3.36445793
41very-low-density lipoprotein particle assembly (GO:0034379)3.31904971
42DNA strand elongation (GO:0022616)3.31592596
43regulation of spindle organization (GO:0090224)3.28003644
44protein-lipid complex assembly (GO:0065005)3.21109662
45folic acid metabolic process (GO:0046655)3.17508894
46formation of translation preinitiation complex (GO:0001731)3.16966428
47regulation of histone H3-K9 methylation (GO:0051570)3.16373454
48IMP biosynthetic process (GO:0006188)3.16255465
49IMP metabolic process (GO:0046040)3.16217613
50mitotic G1 DNA damage checkpoint (GO:0031571)3.15706772
51mRNA stabilization (GO:0048255)3.14161788
52RNA stabilization (GO:0043489)3.14161788
53metaphase plate congression (GO:0051310)3.09976724
54regulation of mitotic spindle organization (GO:0060236)3.09444880
55embryonic process involved in female pregnancy (GO:0060136)3.09180189
56chromatin assembly or disassembly (GO:0006333)3.08611372
57protein localization to chromosome (GO:0034502)3.07321968
58COPI coating of Golgi vesicle (GO:0048205)3.06344036
59Golgi transport vesicle coating (GO:0048200)3.06344036
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04360264
61regulation of telomere maintenance via telomerase (GO:0032210)3.04101330
62peptidyl-lysine dimethylation (GO:0018027)2.99912703
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.99364470
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.99364470
65positive regulation of mitotic sister chromatid separation (GO:1901970)2.99364470
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99310192
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95097064
68positive regulation of SMAD protein import into nucleus (GO:0060391)2.92956156
69nucleobase biosynthetic process (GO:0046112)2.92838233
70* gene silencing by RNA (GO:0031047)2.92686675
71somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91606233
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.91606233
73regulation of hippo signaling (GO:0035330)2.91552485
74DNA replication checkpoint (GO:0000076)2.91288928
75histone H2A ubiquitination (GO:0033522)2.90815681
76maternal placenta development (GO:0001893)2.90070693
77telomere maintenance via semi-conservative replication (GO:0032201)2.89852174
783-UTR-mediated mRNA stabilization (GO:0070935)2.88591972
79ribosome assembly (GO:0042255)2.87868669
80attachment of spindle microtubules to kinetochore (GO:0008608)2.87287585
81histone H3-K9 demethylation (GO:0033169)2.86356102
82DNA conformation change (GO:0071103)2.83908656
83tetrahydrofolate metabolic process (GO:0046653)2.82914508
84establishment of chromosome localization (GO:0051303)2.80046798
85trophectodermal cell differentiation (GO:0001829)2.78762139
86regulation of early endosome to late endosome transport (GO:2000641)2.78509755
87regulation of nucleobase-containing compound transport (GO:0032239)2.73983886
88regulation of chromosome segregation (GO:0051983)2.73437989
89mitotic G1/S transition checkpoint (GO:0044819)2.71507371
90chromosome condensation (GO:0030261)2.70994390
91regulation of cholesterol homeostasis (GO:2000188)2.70457987
92kinetochore organization (GO:0051383)2.68238533
93regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67179622
94mRNA transport (GO:0051028)2.66157497
95DNA replication-independent nucleosome organization (GO:0034724)2.65364423
96DNA replication-independent nucleosome assembly (GO:0006336)2.65364423
97intracellular estrogen receptor signaling pathway (GO:0030520)2.64503010
98regulation of histone H3-K27 methylation (GO:0061085)2.63488293
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63246508
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62961145
101regulation of centrosome cycle (GO:0046605)2.62665734
102G1 DNA damage checkpoint (GO:0044783)2.62521204
103negative regulation of RNA splicing (GO:0033119)2.62514953
104* gene silencing (GO:0016458)2.60917630
105mitotic recombination (GO:0006312)2.60120832
106protein K6-linked ubiquitination (GO:0085020)2.59603330
107pteridine-containing compound biosynthetic process (GO:0042559)2.59439102
108negative regulation of chromosome segregation (GO:0051985)2.58494773
109regulation of gene silencing (GO:0060968)2.57859456
110peptidyl-arginine omega-N-methylation (GO:0035247)2.57799320
111hypotonic response (GO:0006971)2.57388431
112positive regulation of cell cycle checkpoint (GO:1901978)2.57209430
113chromatin remodeling at centromere (GO:0031055)2.57069301
114telomere maintenance via recombination (GO:0000722)2.56746650
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.56327962
116glycine metabolic process (GO:0006544)2.55668753
117negative regulation of mRNA processing (GO:0050686)2.54976267
118COPII vesicle coating (GO:0048208)2.54778011
119negative regulation of DNA repair (GO:0045738)2.48051093
120histone H3-K36 demethylation (GO:0070544)2.46557322
121negative regulation of fibrinolysis (GO:0051918)2.42224799
122protein export from nucleus (GO:0006611)2.40199295
123histone lysine demethylation (GO:0070076)2.37242349
124regulation of histone methylation (GO:0031060)2.36953096
125regulation of bile acid biosynthetic process (GO:0070857)2.33360249
126proline metabolic process (GO:0006560)2.31097484
127DNA synthesis involved in DNA repair (GO:0000731)2.30851656
128regulation of histone H3-K4 methylation (GO:0051569)2.29310610
129viral mRNA export from host cell nucleus (GO:0046784)2.28789715
130pentose-phosphate shunt (GO:0006098)2.28031556
131positive regulation of nuclease activity (GO:0032075)2.26687617
132positive regulation of hormone biosynthetic process (GO:0046886)2.26650659
133positive regulation of histone H3-K4 methylation (GO:0051571)2.26435948
134negative regulation of erythrocyte differentiation (GO:0045647)2.25711012
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.22630120
136cellular hyperosmotic response (GO:0071474)2.22286046
137poly(A)+ mRNA export from nucleus (GO:0016973)2.22135384
138regulation of RNA stability (GO:0043487)2.20479300
139DNA packaging (GO:0006323)2.18393845
140activation of Rac GTPase activity (GO:0032863)2.18196986
141histone demethylation (GO:0016577)2.17561276
142regulation of double-strand break repair (GO:2000779)2.16759610
143positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.15715041
144regulation of mRNA stability (GO:0043488)2.14568062
145positive regulation of isotype switching (GO:0045830)2.14501641
146NADPH regeneration (GO:0006740)2.13042459
147regulation of female gonad development (GO:2000194)2.11913194
148regulation of chromatin binding (GO:0035561)2.11435090
149positive regulation of hormone metabolic process (GO:0032352)2.11240813
150cell-substrate adherens junction assembly (GO:0007045)2.10462693
151focal adhesion assembly (GO:0048041)2.10462693
152regulation of nuclease activity (GO:0032069)2.10430213
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.09801854
154DNA topological change (GO:0006265)2.09755383
155negative regulation of skeletal muscle tissue development (GO:0048642)2.09665239
156ribosomal small subunit biogenesis (GO:0042274)2.08624118
157protein carboxylation (GO:0018214)2.07467410
158peptidyl-glutamic acid carboxylation (GO:0017187)2.07467410
159nucleotide-sugar biosynthetic process (GO:0009226)2.07457213
160chromosome segregation (GO:0007059)2.06008179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.15465957
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.84225223
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.29921272
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.17011888
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13420584
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13059950
7MYC_22102868_ChIP-Seq_BL_Human3.02806567
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85758280
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45969799
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43187015
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.29279720
12AR_21909140_ChIP-Seq_LNCAP_Human2.22216327
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11652626
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06617265
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.02574846
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92807673
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88265461
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83077394
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82406653
20VDR_21846776_ChIP-Seq_THP-1_Human1.80167655
21XRN2_22483619_ChIP-Seq_HELA_Human1.73792981
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73132244
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71349991
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70375709
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67084448
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64263498
27CLOCK_20551151_ChIP-Seq_293T_Human1.62838095
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58229074
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56015794
30KDM5A_27292631_Chip-Seq_BREAST_Human1.54880955
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54163333
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53977537
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53273618
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52812989
35KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52531945
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49848732
37TCF7_22412390_ChIP-Seq_EML_Mouse1.49465245
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49055037
39ZNF263_19887448_ChIP-Seq_K562_Human1.43357444
40CIITA_25753668_ChIP-Seq_RAJI_Human1.41344200
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.37606225
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37543920
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36536176
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36337204
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35501362
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34773530
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34612574
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32131236
49GABP_19822575_ChIP-Seq_HepG2_Human1.31678816
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31648977
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29567245
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29394199
53KDM2B_26808549_Chip-Seq_DND41_Human1.27791500
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26893036
55TFEB_21752829_ChIP-Seq_HELA_Human1.25104928
56VDR_24763502_ChIP-Seq_THP-1_Human1.24047624
57DCP1A_22483619_ChIP-Seq_HELA_Human1.24034792
58MAF_26560356_Chip-Seq_TH1_Human1.23710317
59UTX_26944678_Chip-Seq_JUKART_Human1.23097167
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22912716
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22438611
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22158762
63VDR_23849224_ChIP-Seq_CD4+_Human1.21526843
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.19006995
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18990922
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18812990
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18583453
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18282599
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.18105627
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.18091423
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.17067557
72ATF3_27146783_Chip-Seq_COLON_Human1.16349133
73FOXP3_21729870_ChIP-Seq_TREG_Human1.15928446
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15708060
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15186213
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14360904
77TTF2_22483619_ChIP-Seq_HELA_Human1.14029303
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13849006
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13499082
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13483095
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12729720
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12596389
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11893784
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11685124
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.10937785
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10688381
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10563371
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10468588
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10233879
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10233879
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10233879
92GATA6_25053715_ChIP-Seq_YYC3_Human1.09124287
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08524439
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08450581
95CHD1_26751641_Chip-Seq_LNCaP_Human1.07561967
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06375484
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06219706
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05557579
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04561452
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03265290
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03247038
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03135492
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.03101653
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02292208
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01892575
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01113181
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01103748
108LXR_22292898_ChIP-Seq_THP-1_Human1.00150757
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99251700
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99132186
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98797559
112SPI1_23547873_ChIP-Seq_NB4_Human0.98504944
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98472658
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98104214
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98048514
116MYB_26560356_Chip-Seq_TH1_Human0.95945404
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95903288
118NCOR1_26117541_ChIP-Seq_K562_Human0.95573297
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94867154
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94499266
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94183527
122MAF_26560356_Chip-Seq_TH2_Human0.93161544
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90728814
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90632808
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90487310
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90452024
127GABP_17652178_ChIP-ChIP_JURKAT_Human0.90021258
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89449761
129MYB_26560356_Chip-Seq_TH2_Human0.88536327
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88179655
131RACK7_27058665_Chip-Seq_MCF-7_Human0.86826468
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86276507
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84781115
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83820114
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83211130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.64247890
2MP0010352_gastrointestinal_tract_polyps3.50179556
3MP0004957_abnormal_blastocyst_morpholog3.47358226
4MP0003111_abnormal_nucleus_morphology3.44504957
5MP0010094_abnormal_chromosome_stability3.36923034
6MP0003705_abnormal_hypodermis_morpholog3.19515248
7MP0003077_abnormal_cell_cycle2.92864286
8MP0005451_abnormal_body_composition2.75381767
9MP0008057_abnormal_DNA_replication2.66820527
10MP0001730_embryonic_growth_arrest2.47931612
11MP0005076_abnormal_cell_differentiation2.42978168
12MP0000350_abnormal_cell_proliferation2.21046130
13MP0008260_abnormal_autophagy2.10297819
14MP0010307_abnormal_tumor_latency2.07487452
15MP0005380_embryogenesis_phenotype1.99197380
16MP0001672_abnormal_embryogenesis/_devel1.99197380
17MP0003123_paternal_imprinting1.93481331
18MP0001697_abnormal_embryo_size1.92676242
19MP0002086_abnormal_extraembryonic_tissu1.88538845
20MP0003984_embryonic_growth_retardation1.86604506
21MP0002084_abnormal_developmental_patter1.86083209
22MP0002088_abnormal_embryonic_growth/wei1.84066688
23MP0004197_abnormal_fetal_growth/weight/1.75680125
24MP0002085_abnormal_embryonic_tissue1.74085862
25MP0005058_abnormal_lysosome_morphology1.71613066
26MP0003300_gastrointestinal_ulcer1.71273776
27MP0008877_abnormal_DNA_methylation1.70951030
28MP0010234_abnormal_vibrissa_follicle1.69031718
29MP0002080_prenatal_lethality1.67950934
30MP0003183_abnormal_peptide_metabolism1.66125026
31MP0008932_abnormal_embryonic_tissue1.66102009
32MP0002796_impaired_skin_barrier1.65099806
33MP0002396_abnormal_hematopoietic_system1.64625732
34MP0008007_abnormal_cellular_replicative1.61546273
35MP0000490_abnormal_crypts_of1.56838396
36MP0003806_abnormal_nucleotide_metabolis1.53567497
37MP0009278_abnormal_bone_marrow1.53094918
38MP0009053_abnormal_anal_canal1.52837328
39MP0010030_abnormal_orbit_morphology1.48341489
40MP0001666_abnormal_nutrient_absorption1.47646571
41MP0000678_abnormal_parathyroid_gland1.44704287
42MP0002653_abnormal_ependyma_morphology1.44493760
43MP0002019_abnormal_tumor_incidence1.41474406
44MP0001545_abnormal_hematopoietic_system1.40131804
45MP0005397_hematopoietic_system_phenotyp1.40131804
46MP0004808_abnormal_hematopoietic_stem1.35311559
47MP0003567_abnormal_fetal_cardiomyocyte1.34255376
48MP0002089_abnormal_postnatal_growth/wei1.34086045
49MP0008058_abnormal_DNA_repair1.32584440
50MP0002132_abnormal_respiratory_system1.32458472
51MP0003950_abnormal_plasma_membrane1.31283425
52MP0003890_abnormal_embryonic-extraembry1.31056707
53MP0004264_abnormal_extraembryonic_tissu1.30469834
54MP0003718_maternal_effect1.28929268
55MP0001915_intracranial_hemorrhage1.28881496
56MP0003566_abnormal_cell_adhesion1.28306235
57MP0003941_abnormal_skin_development1.28304623
58MP0005023_abnormal_wound_healing1.28053496
59MP0001849_ear_inflammation1.26902334
60MP0004185_abnormal_adipocyte_glucose1.26206662
61MP0000313_abnormal_cell_death1.23320027
62MP0001873_stomach_inflammation1.23009184
63MP0003119_abnormal_digestive_system1.22042581
64MP0003656_abnormal_erythrocyte_physiolo1.19810014
65MP0000703_abnormal_thymus_morphology1.17605851
66MP0003763_abnormal_thymus_physiology1.16985200
67MP0005501_abnormal_skin_physiology1.16975950
68MP0005360_urolithiasis1.16965389
69MP0003303_peritoneal_inflammation1.14346708
70MP0000733_abnormal_muscle_development1.14015834
71MP0005464_abnormal_platelet_physiology1.12913599
72MP0001348_abnormal_lacrimal_gland1.12624910
73MP0001293_anophthalmia1.11352020
74MP0001835_abnormal_antigen_presentation1.11154608
75MP0003283_abnormal_digestive_organ1.07538648
76MP0005409_darkened_coat_color1.06709964
77MP0004233_abnormal_muscle_weight1.06425509
78MP0003172_abnormal_lysosome_physiology1.04373121
79MP0003436_decreased_susceptibility_to1.02791768
80MP0009840_abnormal_foam_cell1.02115642
81MP0009672_abnormal_birth_weight1.01719857
82MP0003121_genomic_imprinting1.01162766
83MP0002398_abnormal_bone_marrow0.99391716
84MP0006082_CNS_inflammation0.96433536
85MP0002269_muscular_atrophy0.93425901
86MP0002722_abnormal_immune_system0.92322496
87MP0003453_abnormal_keratinocyte_physiol0.91679207
88MP0000689_abnormal_spleen_morphology0.91078361
89MP0004947_skin_inflammation0.90507535
90MP0009703_decreased_birth_body0.90105713
91MP0003191_abnormal_cellular_cholesterol0.89992628
92MP0002139_abnormal_hepatobiliary_system0.89754661
93MP0005666_abnormal_adipose_tissue0.89299312
94MP0003221_abnormal_cardiomyocyte_apopto0.88877396
95MP0002006_tumorigenesis0.88267511
96MP0002877_abnormal_melanocyte_morpholog0.87771909
97MP0005395_other_phenotype0.87533123
98MP0010155_abnormal_intestine_physiology0.87103249
99MP0001853_heart_inflammation0.86520194
100MP0000477_abnormal_intestine_morphology0.85265461
101MP0000598_abnormal_liver_morphology0.85059037
102MP0001216_abnormal_epidermal_layer0.84898827
103MP0002092_abnormal_eye_morphology0.84477647
104MP0002925_abnormal_cardiovascular_devel0.84337642
105MP0000537_abnormal_urethra_morphology0.84253873
106MP0001881_abnormal_mammary_gland0.83618943
107MP0003115_abnormal_respiratory_system0.82867053
108MP0009333_abnormal_splenocyte_physiolog0.81590529
109MP0001145_abnormal_male_reproductive0.81307422
110MP0005621_abnormal_cell_physiology0.80876508
111MP0008770_decreased_survivor_rate0.80225429
112MP0000685_abnormal_immune_system0.79469955
113MP0002166_altered_tumor_susceptibility0.79207441
114MP0002210_abnormal_sex_determination0.77685189
115MP0005408_hypopigmentation0.76467165
116MP0002111_abnormal_tail_morphology0.75216359
117MP0006054_spinal_hemorrhage0.74976196
118MP0000858_altered_metastatic_potential0.74812400
119MP0010630_abnormal_cardiac_muscle0.74504814
120MP0000266_abnormal_heart_morphology0.74435750
121MP0005375_adipose_tissue_phenotype0.73796356
122MP0005384_cellular_phenotype0.72986152
123MP0003699_abnormal_female_reproductive0.72981387
124MP0000653_abnormal_sex_gland0.72890670
125MP0003091_abnormal_cell_migration0.72831453
126MP0001929_abnormal_gametogenesis0.72788421
127MP0000371_diluted_coat_color0.72551703
128MP0003868_abnormal_feces_composition0.72361113
129MP0000627_abnormal_mammary_gland0.71736297
130MP0005365_abnormal_bile_salt0.71429487
131MP0002429_abnormal_blood_cell0.69689064
132MP0000428_abnormal_craniofacial_morphol0.69484968
133MP0001119_abnormal_female_reproductive0.68531548
134MP0000609_abnormal_liver_physiology0.67187919
135MP0003786_premature_aging0.62511223

Predicted human phenotypes

RankGene SetZ-score
1Flat acetabular roof (HP:0003180)3.99616591
2Ependymoma (HP:0002888)3.85638890
3Rhabdomyosarcoma (HP:0002859)3.08803307
4Basal cell carcinoma (HP:0002671)3.04945321
5Birth length less than 3rd percentile (HP:0003561)2.88049208
6Astrocytoma (HP:0009592)2.86246937
7Abnormality of the astrocytes (HP:0100707)2.86246937
8Colon cancer (HP:0003003)2.85841058
9Facial hemangioma (HP:0000329)2.83343717
10Asymmetry of the thorax (HP:0001555)2.72556659
11Selective tooth agenesis (HP:0001592)2.70831845
12Neoplasm of striated muscle (HP:0009728)2.58429988
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57920149
14Progressive external ophthalmoplegia (HP:0000590)2.57726325
15Abnormality of the common coagulation pathway (HP:0010990)2.56269482
16Abnormal gallbladder physiology (HP:0012438)2.53864078
17Cholecystitis (HP:0001082)2.53864078
18Abnormality of carpal bone ossification (HP:0006257)2.51932886
19Abnormal tarsal ossification (HP:0008369)2.50982636
20Increased density of long bones (HP:0006392)2.50959957
21Medulloblastoma (HP:0002885)2.49706055
22Breast hypoplasia (HP:0003187)2.49426975
23Neoplasm of the oral cavity (HP:0100649)2.46042101
24Ulnar bowing (HP:0003031)2.42068919
25Heterotopia (HP:0002282)2.42048408
26Increased nuchal translucency (HP:0010880)2.41120603
27Biliary tract neoplasm (HP:0100574)2.39882682
28Malignant gastrointestinal tract tumors (HP:0006749)2.36756713
29Gastrointestinal carcinoma (HP:0002672)2.36756713
30Abnormal foot bone ossification (HP:0010675)2.35773126
31Progressive muscle weakness (HP:0003323)2.35713043
32Cerebral aneurysm (HP:0004944)2.34755793
33Overlapping toe (HP:0001845)2.33509221
34Agnosia (HP:0010524)2.29782110
35Hemorrhage of the eye (HP:0011885)2.26086146
36Spastic diplegia (HP:0001264)2.25986640
37Volvulus (HP:0002580)2.25320867
38Cortical dysplasia (HP:0002539)2.24590429
39Patellar aplasia (HP:0006443)2.24355760
40Capillary hemangiomas (HP:0005306)2.23812434
41Abnormality of the labia minora (HP:0012880)2.23796524
42Prominent nose (HP:0000448)2.21674975
43Deviation of the thumb (HP:0009603)2.21579914
44Rectal prolapse (HP:0002035)2.20639779
45Cafe-au-lait spot (HP:0000957)2.19907025
46Pseudobulbar signs (HP:0002200)2.19592298
47Papillary thyroid carcinoma (HP:0002895)2.17685006
48Syringomyelia (HP:0003396)2.17155208
49Spinal cord lesions (HP:0100561)2.17155208
50Malnutrition (HP:0004395)2.16996253
51Hypercholesterolemia (HP:0003124)2.15710727
52Proximal placement of thumb (HP:0009623)2.12859047
53Achilles tendon contracture (HP:0001771)2.11665660
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11012872
55Angiofibromas (HP:0010615)2.10609828
56Adenoma sebaceum (HP:0009720)2.10609828
57Abnormality of the Achilles tendon (HP:0005109)2.10314370
58Genu recurvatum (HP:0002816)2.10213247
59High pitched voice (HP:0001620)2.10181131
60Abnormality of the thoracic spine (HP:0100711)2.09308458
61Ankyloglossia (HP:0010296)2.09265828
62Diastasis recti (HP:0001540)2.08868647
63Hypobetalipoproteinemia (HP:0003563)2.08121043
64Chromsome breakage (HP:0040012)2.07320545
65Deep palmar crease (HP:0006191)2.07029936
66Protrusio acetabuli (HP:0003179)2.05621501
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04603341
68Sandal gap (HP:0001852)2.04292783
69Acanthocytosis (HP:0001927)2.04125939
70Prolonged partial thromboplastin time (HP:0003645)2.04043153
71Aplasia/Hypoplasia of the patella (HP:0006498)2.03588872
72Nephroblastoma (Wilms tumor) (HP:0002667)2.01979529
73Premature ovarian failure (HP:0008209)2.00908867
74Abnormality of the fingertips (HP:0001211)2.00897765
75Absent radius (HP:0003974)2.00561668
76Abnormality of chromosome stability (HP:0003220)1.98811734
77Glioma (HP:0009733)1.98560503
78Abnormality of the lower motor neuron (HP:0002366)1.97882854
79Multiple enchondromatosis (HP:0005701)1.92739002
80Squamous cell carcinoma (HP:0002860)1.92327586
81Ragged-red muscle fibers (HP:0003200)1.92318122
82Short humerus (HP:0005792)1.92113236
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92108328
84Right ventricular cardiomyopathy (HP:0011663)1.91937820
85Orthostatic hypotension (HP:0001278)1.91569090
86Shallow orbits (HP:0000586)1.91211290
87Broad palm (HP:0001169)1.90654648
88Osteomalacia (HP:0002749)1.89336537
89Pelvic girdle muscle weakness (HP:0003749)1.89307246
90Ankle contracture (HP:0006466)1.88877170
91Abnormal ossification of hand bones (HP:0005921)1.88321901
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87224387
93Short 4th metacarpal (HP:0010044)1.87224387
94Small epiphyses (HP:0010585)1.87183890
95Absent forearm bone (HP:0003953)1.86395977
96Aplasia involving forearm bones (HP:0009822)1.86395977
97Aplasia/hypoplasia of the humerus (HP:0006507)1.85749683
98Abnormality of the lumbar spine (HP:0100712)1.84474727
99Hyperacusis (HP:0010780)1.82962935
10011 pairs of ribs (HP:0000878)1.82797177
101Rib fusion (HP:0000902)1.82576113
102Microvesicular hepatic steatosis (HP:0001414)1.82218259
103Uterine neoplasm (HP:0010784)1.81575128
104Abnormality of the calcaneus (HP:0008364)1.81258298
105Embryonal renal neoplasm (HP:0011794)1.81012744
106Septate vagina (HP:0001153)1.80349600
107Atresia of the external auditory canal (HP:0000413)1.79880983
108Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78878748
109Shawl scrotum (HP:0000049)1.78550162
110Long eyelashes (HP:0000527)1.77947030
111Subacute progressive viral hepatitis (HP:0006572)1.77085527
112Polygenic inheritance (HP:0010982)1.76965356
113Radial bowing (HP:0002986)1.76857030
114Intestinal polyp (HP:0005266)1.76733901
115Myelodysplasia (HP:0002863)1.76504838
116Cutis marmorata (HP:0000965)1.76251114
117Combined immunodeficiency (HP:0005387)1.75805231
118Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75296706
119Short 1st metacarpal (HP:0010034)1.75296706
120Metaphyseal cupping (HP:0003021)1.74902551
121Cupped ribs (HP:0000887)1.73969085
122Degeneration of anterior horn cells (HP:0002398)1.73779097
123Abnormality of the anterior horn cell (HP:0006802)1.73779097
124Progressive hearing impairment (HP:0001730)1.73766478
125Back pain (HP:0003418)1.73326455
126Neoplasm of the pancreas (HP:0002894)1.73275541
127Hand muscle atrophy (HP:0009130)1.73260836
128Abnormality of pyrimidine metabolism (HP:0004353)1.72944140
129Amyotrophic lateral sclerosis (HP:0007354)1.71417232
130Oral leukoplakia (HP:0002745)1.71247491
131Fibroma (HP:0010614)1.70004729
132Intestinal polyposis (HP:0200008)1.69528700
133Eczematoid dermatitis (HP:0000976)1.69443050
134Trismus (HP:0000211)1.69317864
135Mitral valve prolapse (HP:0001634)1.68783777
136Broad thumb (HP:0011304)1.68667633
137T lymphocytopenia (HP:0005403)1.68630557
138Impulsivity (HP:0100710)1.68566002
139Metaphyseal irregularity (HP:0003025)1.68309525
140Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68108738
141Spinal cord compression (HP:0002176)1.68021194
142Hypophosphatemic rickets (HP:0004912)1.67713690
143Male infertility (HP:0003251)1.67267380
144Deep venous thrombosis (HP:0002625)1.66992258
145Fatigue (HP:0012378)1.66211284
146Posterior subcapsular cataract (HP:0007787)1.65746660
147Abnormality of the acetabulum (HP:0003170)1.65685807
148Abnormality of the 4th metacarpal (HP:0010012)1.65457385
149Abnormality of macrophages (HP:0004311)1.65366494
150Aneurysm (HP:0002617)1.64563422
151Absent thumb (HP:0009777)1.64522151
152Micronodular cirrhosis (HP:0001413)1.64217453
153Leiomyosarcoma (HP:0100243)1.63252517
154Uterine leiomyosarcoma (HP:0002891)1.63252517
155Abnormality of the salivary glands (HP:0010286)1.62895112
156Deep philtrum (HP:0002002)1.62520474
157Increased serum ferritin (HP:0003281)1.61378536
158Broad alveolar ridges (HP:0000187)1.60367532
159Abnormality of small intestinal villus morphology (HP:0011472)1.59633752
160Villous atrophy (HP:0011473)1.59633752
161Abnormal hand bone ossification (HP:0010660)1.59436426
162Myocardial infarction (HP:0001658)1.59082778
163Loss of speech (HP:0002371)1.59044851
164Seborrheic dermatitis (HP:0001051)1.58942005
165Renal cell carcinoma (HP:0005584)1.58555168
166Wide nose (HP:0000445)1.58168554
167Neonatal death (HP:0003811)1.56227574
168Viral hepatitis (HP:0006562)1.55387133
169Esophageal varix (HP:0002040)1.55062111
170Centrally nucleated skeletal muscle fibers (HP:0003687)1.54417358
171Disproportionate tall stature (HP:0001519)1.53901282
172Joint hemorrhage (HP:0005261)1.53651668
173Dysmetric saccades (HP:0000641)1.50208788
174Cutaneous melanoma (HP:0012056)1.49411638
175Acute myeloid leukemia (HP:0004808)1.49349682
176Cellulitis (HP:0100658)1.48407229
177Ventricular tachycardia (HP:0004756)1.46187962
178Lip pit (HP:0100267)1.45858777
179Gastrointestinal stroma tumor (HP:0100723)1.45851066
180Elevated alkaline phosphatase (HP:0003155)1.43855430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.68332871
2MAP3K133.54340889
3CDC73.41689009
4EEF2K3.17505047
5PKN23.17301432
6SMG12.81884342
7MAP3K102.76494582
8TRIB32.75251705
9NEK22.71260186
10BUB12.28790787
11WEE12.21930054
12PRPF4B2.09102071
13NME22.08012501
14IRAK32.05585354
15NEK12.04529707
16TTK1.99804556
17MAP3K141.99448747
18STK101.98080390
19MAP3K91.93913990
20STK241.92059270
21SCYL21.86192673
22ICK1.81464531
23LATS11.72754860
24MAP3K81.69634435
25ERN11.68749483
26ARAF1.65286460
27CDK41.56614087
28ALK1.56327231
29BRAF1.55193391
30CDK71.47636148
31RPS6KB21.45592200
32EIF2AK11.40144393
33MAP4K11.34312198
34IRAK41.28204483
35PLK11.27590918
36CDK61.26383280
37FLT31.26257198
38LRRK21.23867027
39LATS21.23196404
40STK31.22022094
41TTN1.19106230
42MTOR1.18278100
43CHEK21.16531942
44MST1R1.15461133
45MAP3K61.10522640
46KSR21.08995863
47MELK1.08244852
48AURKB1.07098284
49PAK41.05982060
50BMX1.05593934
51EPHA21.05189429
52RPS6KA41.04872550
53ACVR1B1.04238791
54TESK21.04021942
55MAP3K111.03567002
56ATR1.03134160
57CHEK11.01698377
58DYRK31.00886556
59TAOK10.99774023
60PDGFRA0.95747841
61PTK60.92796805
62MAP3K10.92702605
63GRK60.91063253
64MET0.90184718
65TYRO30.90069510
66PBK0.89536985
67EIF2AK30.88845142
68PIM10.88078886
69PASK0.86284712
70RIPK10.84954610
71CDK20.83920448
72MAP2K30.81971759
73MAP3K20.81912040
74TYK20.81353885
75WNK10.79549234
76BRD40.76438443
77TAOK30.74975589
78PDPK10.74867188
79SIK10.74104424
80RIPK40.71947961
81STK40.71540114
82FGFR10.70759911
83MOS0.70744392
84FGFR40.70335337
85ATM0.68940311
86RAF10.67421391
87AURKA0.66850197
88KDR0.64602691
89NEK60.63105188
90BRSK20.61815646
91DMPK0.61612381
92FGFR30.61089315
93PRKD30.60633545
94TSSK60.60619753
95TGFBR10.58319861
96CDK90.58316082
97JAK30.57772483
98PAK20.57674506
99MAPK110.57045447
100TAOK20.54412774
101PDK10.53400060
102DDR20.53327511
103FGR0.52702338
104CDK10.51853092
105AKT20.51454264
106CSK0.49348997
107MAP3K70.48637421
108ILK0.48519533
109MAP3K30.47283877
110BCKDK0.46276719
111TAF10.44434460
112DYRK1B0.44105998
113SRPK10.43481791
114MAP3K120.42845042
115RET0.42531924
116SIK30.42239696
117TRPM70.41451630
118NEK90.41036483
119TBK10.40635123
120IRAK20.40572623
121RPS6KA10.39698440
122BLK0.38910692
123TLK10.38608371
124CSNK1E0.38561719
125MAP3K50.37640708
126CDK80.37373500
127MST40.37012108
128MAPKAPK30.36687746
129ZAP700.36352765
130PRKCI0.36285880
131CSNK1D0.35914764
132CSNK2A20.34087547
133KSR10.33814784
134PRKDC0.33741618
135PTK20.33302115
136MAPK140.33291193

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.82786057
2Mismatch repair_Homo sapiens_hsa034303.18163122
3One carbon pool by folate_Homo sapiens_hsa006702.85369894
4RNA transport_Homo sapiens_hsa030132.83243247
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81797498
6Cell cycle_Homo sapiens_hsa041102.57795034
7Base excision repair_Homo sapiens_hsa034102.41494424
8Spliceosome_Homo sapiens_hsa030402.33102842
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09004027
10mRNA surveillance pathway_Homo sapiens_hsa030152.04741400
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01382985
12Nucleotide excision repair_Homo sapiens_hsa034201.99168406
13Other glycan degradation_Homo sapiens_hsa005111.89066275
14Biosynthesis of amino acids_Homo sapiens_hsa012301.64661918
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53284048
16p53 signaling pathway_Homo sapiens_hsa041151.51034919
17Homologous recombination_Homo sapiens_hsa034401.48091038
18mTOR signaling pathway_Homo sapiens_hsa041501.47249513
19RNA degradation_Homo sapiens_hsa030181.43574003
20Bladder cancer_Homo sapiens_hsa052191.40562158
21Lysine degradation_Homo sapiens_hsa003101.37180981
22MicroRNAs in cancer_Homo sapiens_hsa052061.34490571
23Selenocompound metabolism_Homo sapiens_hsa004501.32908008
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.31646856
25Chronic myeloid leukemia_Homo sapiens_hsa052201.31271486
26Nitrogen metabolism_Homo sapiens_hsa009101.30180596
27Viral carcinogenesis_Homo sapiens_hsa052031.28969887
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27968916
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24363863
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21254329
31Thyroid cancer_Homo sapiens_hsa052161.21043055
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.19705937
33Oocyte meiosis_Homo sapiens_hsa041141.18424993
34Non-homologous end-joining_Homo sapiens_hsa034501.15866231
35Influenza A_Homo sapiens_hsa051641.13803247
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13574190
37Fanconi anemia pathway_Homo sapiens_hsa034601.12562135
38HTLV-I infection_Homo sapiens_hsa051661.12526737
39Complement and coagulation cascades_Homo sapiens_hsa046101.08057834
40Adherens junction_Homo sapiens_hsa045201.07857524
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.07544905
42Systemic lupus erythematosus_Homo sapiens_hsa053221.05672774
43Fructose and mannose metabolism_Homo sapiens_hsa000511.04858074
44Small cell lung cancer_Homo sapiens_hsa052221.03860421
45Leishmaniasis_Homo sapiens_hsa051401.01833362
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00210345
47Colorectal cancer_Homo sapiens_hsa052100.99049211
48Notch signaling pathway_Homo sapiens_hsa043300.98609336
49Measles_Homo sapiens_hsa051620.97767493
50Pyrimidine metabolism_Homo sapiens_hsa002400.96427792
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96174086
52Arginine biosynthesis_Homo sapiens_hsa002200.96141785
53Hepatitis C_Homo sapiens_hsa051600.96082918
54Antigen processing and presentation_Homo sapiens_hsa046120.96061312
55Galactose metabolism_Homo sapiens_hsa000520.94606088
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.94527180
57Non-small cell lung cancer_Homo sapiens_hsa052230.93433426
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89556852
59Hippo signaling pathway_Homo sapiens_hsa043900.87831706
60Vitamin digestion and absorption_Homo sapiens_hsa049770.87668747
61Toxoplasmosis_Homo sapiens_hsa051450.86656184
62Basal transcription factors_Homo sapiens_hsa030220.86455748
63Pancreatic cancer_Homo sapiens_hsa052120.86250802
64Sulfur relay system_Homo sapiens_hsa041220.86141292
65Acute myeloid leukemia_Homo sapiens_hsa052210.85260860
66Fatty acid biosynthesis_Homo sapiens_hsa000610.84970224
67Carbon metabolism_Homo sapiens_hsa012000.84658722
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83578695
69Ribosome_Homo sapiens_hsa030100.83417236
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83341329
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82416340
72Pentose phosphate pathway_Homo sapiens_hsa000300.80806595
73Herpes simplex infection_Homo sapiens_hsa051680.80187752
74RNA polymerase_Homo sapiens_hsa030200.80172303
75VEGF signaling pathway_Homo sapiens_hsa043700.79484104
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79326141
77TGF-beta signaling pathway_Homo sapiens_hsa043500.78998124
78N-Glycan biosynthesis_Homo sapiens_hsa005100.78945561
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78940901
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78149470
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77861131
82Epstein-Barr virus infection_Homo sapiens_hsa051690.76868620
83TNF signaling pathway_Homo sapiens_hsa046680.76711603
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73853429
85Osteoclast differentiation_Homo sapiens_hsa043800.73062847
86Endometrial cancer_Homo sapiens_hsa052130.71419537
87ErbB signaling pathway_Homo sapiens_hsa040120.70496174
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70411305
89Proteoglycans in cancer_Homo sapiens_hsa052050.70079527
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69220602
91Hepatitis B_Homo sapiens_hsa051610.68306960
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67240332
93Inositol phosphate metabolism_Homo sapiens_hsa005620.67176258
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65746247
95Dorso-ventral axis formation_Homo sapiens_hsa043200.65418950
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64813082
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64400222
98Amoebiasis_Homo sapiens_hsa051460.64025557
99Prion diseases_Homo sapiens_hsa050200.63808078
100B cell receptor signaling pathway_Homo sapiens_hsa046620.63356122
101AMPK signaling pathway_Homo sapiens_hsa041520.62107012
102Staphylococcus aureus infection_Homo sapiens_hsa051500.61458862
103Viral myocarditis_Homo sapiens_hsa054160.61411249
104Primary immunodeficiency_Homo sapiens_hsa053400.60999456
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60619960
106Folate biosynthesis_Homo sapiens_hsa007900.59975999
107Prolactin signaling pathway_Homo sapiens_hsa049170.58650045
108Apoptosis_Homo sapiens_hsa042100.57680698
109Shigellosis_Homo sapiens_hsa051310.56528008
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.56450300
111Fat digestion and absorption_Homo sapiens_hsa049750.55283190
112HIF-1 signaling pathway_Homo sapiens_hsa040660.55204622
113Vitamin B6 metabolism_Homo sapiens_hsa007500.54767102
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53813420
115FoxO signaling pathway_Homo sapiens_hsa040680.53228811
116Insulin resistance_Homo sapiens_hsa049310.52805104
117Renin-angiotensin system_Homo sapiens_hsa046140.52402565
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.50638674
119Prostate cancer_Homo sapiens_hsa052150.49865313
120T cell receptor signaling pathway_Homo sapiens_hsa046600.48621569
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47912131
122Basal cell carcinoma_Homo sapiens_hsa052170.47383488
123Legionellosis_Homo sapiens_hsa051340.46949039
124Sphingolipid metabolism_Homo sapiens_hsa006000.46572196
125Glioma_Homo sapiens_hsa052140.43780280
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43609659
127Insulin signaling pathway_Homo sapiens_hsa049100.43524701
128Renal cell carcinoma_Homo sapiens_hsa052110.40289908
129Glucagon signaling pathway_Homo sapiens_hsa049220.39382805
130Pathways in cancer_Homo sapiens_hsa052000.38393713
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36829458
132Focal adhesion_Homo sapiens_hsa045100.36490937
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.35498664
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.34607092

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