CNOT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)4.35732276
2maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.29572753
3DNA unwinding involved in DNA replication (GO:0006268)4.28103528
4replication fork processing (GO:0031297)4.20537413
5mitotic metaphase plate congression (GO:0007080)4.10293512
6DNA strand elongation involved in DNA replication (GO:0006271)4.09554594
7DNA strand renaturation (GO:0000733)4.08920920
8protein localization to kinetochore (GO:0034501)4.08553039
9metaphase plate congression (GO:0051310)4.06165550
10telomere maintenance via semi-conservative replication (GO:0032201)4.02282001
11mitotic sister chromatid cohesion (GO:0007064)3.95887618
12kinetochore organization (GO:0051383)3.90416507
13DNA strand elongation (GO:0022616)3.90394337
14viral mRNA export from host cell nucleus (GO:0046784)3.88964992
15mitotic chromosome condensation (GO:0007076)3.87232876
16nucleotide-excision repair, DNA gap filling (GO:0006297)3.79173207
17protein prenylation (GO:0018342)3.73482624
18prenylation (GO:0097354)3.73482624
19neural tube formation (GO:0001841)3.70418028
20mitotic recombination (GO:0006312)3.70179034
21telomere maintenance via recombination (GO:0000722)3.67966021
22DNA double-strand break processing (GO:0000729)3.66346397
23protein localization to chromosome, centromeric region (GO:0071459)3.65787481
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.65195818
25negative regulation of DNA recombination (GO:0045910)3.64762262
26mitotic nuclear envelope disassembly (GO:0007077)3.63213984
27nuclear pore organization (GO:0006999)3.62708213
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.62667335
29telomere maintenance via telomere lengthening (GO:0010833)3.58139080
30establishment of chromosome localization (GO:0051303)3.57214319
31nuclear pore complex assembly (GO:0051292)3.55000066
32CENP-A containing nucleosome assembly (GO:0034080)3.53768231
33DNA duplex unwinding (GO:0032508)3.52047868
34DNA geometric change (GO:0032392)3.50405550
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43776405
36attachment of spindle microtubules to kinetochore (GO:0008608)3.43348872
37response to pheromone (GO:0019236)3.42077093
38DNA replication-independent nucleosome assembly (GO:0006336)3.41747895
39DNA replication-independent nucleosome organization (GO:0034724)3.41747895
40nuclear envelope disassembly (GO:0051081)3.41638558
41membrane disassembly (GO:0030397)3.41638558
42centriole replication (GO:0007099)3.41444932
43chromatin remodeling at centromere (GO:0031055)3.41210054
44behavioral response to nicotine (GO:0035095)3.40876202
45kinetochore assembly (GO:0051382)3.37538180
46IMP biosynthetic process (GO:0006188)3.37086027
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36123831
48regulation of DNA damage checkpoint (GO:2000001)3.30962516
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29984740
50negative regulation of RNA splicing (GO:0033119)3.29750954
51sister chromatid segregation (GO:0000819)3.28722224
52* RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.28552746
53regulation of spindle organization (GO:0090224)3.28531014
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28077504
55V(D)J recombination (GO:0033151)3.27051173
56telomere maintenance (GO:0000723)3.25889480
57regulation of sister chromatid cohesion (GO:0007063)3.24774233
58recombinational repair (GO:0000725)3.23938930
59nucleobase biosynthetic process (GO:0046112)3.23627644
60respiratory chain complex IV assembly (GO:0008535)3.23484234
61purine nucleobase biosynthetic process (GO:0009113)3.23315813
62double-strand break repair via homologous recombination (GO:0000724)3.23074539
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.21271491
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21271491
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21271491
66negative regulation of sister chromatid segregation (GO:0033046)3.21271491
67telomere organization (GO:0032200)3.20615331
68formation of translation preinitiation complex (GO:0001731)3.20029031
69establishment of integrated proviral latency (GO:0075713)3.19173967
70mitotic sister chromatid segregation (GO:0000070)3.18089848
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17342161
72regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17289998
73negative regulation of chromosome segregation (GO:0051985)3.17246717
74telomere maintenance via telomerase (GO:0007004)3.16792099
75ribosomal small subunit assembly (GO:0000028)3.16104422
76negative regulation of thymocyte apoptotic process (GO:0070244)3.14884195
77somite development (GO:0061053)3.14117725
78translesion synthesis (GO:0019985)3.12804287
79regulation of DNA endoreduplication (GO:0032875)3.12267380
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11787788
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.11041782
82regulation of mitotic spindle checkpoint (GO:1903504)3.11041782
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10052170
84regulation of chromosome segregation (GO:0051983)3.09610733
85histone exchange (GO:0043486)3.08154740
86spindle assembly checkpoint (GO:0071173)3.07069162
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06676339
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.06676339
89regulation of sister chromatid segregation (GO:0033045)3.06305536
90regulation of mitotic sister chromatid separation (GO:0010965)3.06305536
91regulation of mitotic sister chromatid segregation (GO:0033047)3.06305536
92indolalkylamine metabolic process (GO:0006586)3.06135860
93meiotic chromosome segregation (GO:0045132)3.05664247
94protein complex biogenesis (GO:0070271)3.05470904
95mitotic spindle assembly checkpoint (GO:0007094)3.05325806
96negative regulation of translation, ncRNA-mediated (GO:0040033)3.01446760
97regulation of translation, ncRNA-mediated (GO:0045974)3.01446760
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01446760
99DNA topological change (GO:0006265)3.00405124
100spindle checkpoint (GO:0031577)2.99764976
101regulation of histone H3-K9 methylation (GO:0051570)2.99234274
102DNA ligation (GO:0006266)2.97857603
103negative regulation of mRNA processing (GO:0050686)2.97547318
104DNA replication-dependent nucleosome organization (GO:0034723)2.97458967
105DNA replication-dependent nucleosome assembly (GO:0006335)2.97458967
106DNA synthesis involved in DNA repair (GO:0000731)2.95089329
107histone H2A acetylation (GO:0043968)2.93443387
108DNA deamination (GO:0045006)2.93378964
109DNA replication checkpoint (GO:0000076)2.93252306
110DNA conformation change (GO:0071103)2.93186217
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.93053717
112NADH dehydrogenase complex assembly (GO:0010257)2.93053717
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93053717
114mitotic spindle checkpoint (GO:0071174)2.92604513
115IMP metabolic process (GO:0046040)2.92222536
116mitochondrial respiratory chain complex assembly (GO:0033108)2.92009131
117pseudouridine synthesis (GO:0001522)2.90688148
118regulation of meiosis I (GO:0060631)2.88676652
119retinal cone cell development (GO:0046549)2.88608672
120negative regulation of histone methylation (GO:0031061)2.88252078
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87369343
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87369343
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.87369343
124L-fucose metabolic process (GO:0042354)2.86823430
125L-fucose catabolic process (GO:0042355)2.86823430
126fucose catabolic process (GO:0019317)2.86823430
127somatic cell DNA recombination (GO:0016444)2.86654832
128somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.86654832
129epithelial cilium movement (GO:0003351)2.86498540
130mRNA splice site selection (GO:0006376)2.85764310
131piRNA metabolic process (GO:0034587)2.85483854
132postreplication repair (GO:0006301)2.84607262
133chromatin assembly or disassembly (GO:0006333)2.84277455
134single strand break repair (GO:0000012)2.83951899
135reciprocal DNA recombination (GO:0035825)2.83533043
136reciprocal meiotic recombination (GO:0007131)2.83533043
137DNA demethylation (GO:0080111)2.82754412
138pore complex assembly (GO:0046931)2.81106984
139cilium morphogenesis (GO:0060271)2.80202822
140intraciliary transport (GO:0042073)2.80114175
141monoubiquitinated protein deubiquitination (GO:0035520)2.78643224
142axoneme assembly (GO:0035082)2.77525894
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77312087
144cytochrome complex assembly (GO:0017004)2.76633354
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.76304456
146synapsis (GO:0007129)2.76258398
147preassembly of GPI anchor in ER membrane (GO:0016254)2.74481049
148rRNA catabolic process (GO:0016075)2.73261311
149nonmotile primary cilium assembly (GO:0035058)2.72212220
150tryptophan catabolic process (GO:0006569)2.71805228
151indole-containing compound catabolic process (GO:0042436)2.71805228
152indolalkylamine catabolic process (GO:0046218)2.71805228
153tryptophan metabolic process (GO:0006568)2.65130360
154protein polyglutamylation (GO:0018095)2.62201634
155resolution of meiotic recombination intermediates (GO:0000712)2.61987663
156keratinocyte development (GO:0003334)2.59243097
157photoreceptor cell development (GO:0042461)2.56482048
158cornea development in camera-type eye (GO:0061303)2.54941648
159establishment of protein localization to Golgi (GO:0072600)2.54912994
160histone mRNA metabolic process (GO:0008334)2.54631819
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.54131458
162water-soluble vitamin biosynthetic process (GO:0042364)2.53545389
163microtubule anchoring (GO:0034453)2.53383170
164somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.52904745
165isotype switching (GO:0045190)2.52904745
166somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.52904745
167anterograde synaptic vesicle transport (GO:0048490)2.52445081
168kynurenine metabolic process (GO:0070189)2.50732832
169protein K11-linked deubiquitination (GO:0035871)2.49761141
170negative regulation of heart rate (GO:0010459)2.49239097
171prostate gland growth (GO:0060736)2.48398992
172establishment of protein localization to mitochondrial membrane (GO:0090151)2.48269210
173negative regulation of telomere maintenance (GO:0032205)2.48251714
174sympathetic nervous system development (GO:0048485)2.47651178
175positive regulation of mRNA processing (GO:0050685)2.47054130
176photoreceptor cell maintenance (GO:0045494)2.46448696
177somatic diversification of immunoglobulins (GO:0016445)2.46134970
178kidney morphogenesis (GO:0060993)2.45968654
179ncRNA catabolic process (GO:0034661)2.44328683
180DNA catabolic process, exonucleolytic (GO:0000738)2.43906314
181protein K6-linked ubiquitination (GO:0085020)2.43050835
182regulation of helicase activity (GO:0051095)2.40199033
183intra-S DNA damage checkpoint (GO:0031573)2.38695215
184RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.38342209
185tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38342209
186regulation of telomere maintenance (GO:0032204)2.38318436
187platelet dense granule organization (GO:0060155)2.38186026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.37432659
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.51689975
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.68537436
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.63747603
5* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87046160
6* ZNF274_21170338_ChIP-Seq_K562_Hela2.84733174
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70525969
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.69830661
9VDR_22108803_ChIP-Seq_LS180_Human2.69521543
10FUS_26573619_Chip-Seq_HEK293_Human2.62787667
11GBX2_23144817_ChIP-Seq_PC3_Human2.59113630
12IGF1R_20145208_ChIP-Seq_DFB_Human2.58404667
13TAF15_26573619_Chip-Seq_HEK293_Human2.56893212
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55860281
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55293391
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55273469
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53768684
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.52167292
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48895796
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46565292
21* EST1_17652178_ChIP-ChIP_JURKAT_Human2.43470817
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41614731
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.33967030
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32805613
25* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32546828
26CIITA_25753668_ChIP-Seq_RAJI_Human2.27820783
27MYC_22102868_ChIP-Seq_BL_Human2.25911490
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.23862210
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17106719
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16591500
31* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15252102
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13176813
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12978671
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12839365
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11898882
36VDR_23849224_ChIP-Seq_CD4+_Human2.11123907
37* P300_19829295_ChIP-Seq_ESCs_Human2.08002752
38TP63_19390658_ChIP-ChIP_HaCaT_Human2.05573932
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05345044
40NOTCH1_21737748_ChIP-Seq_TLL_Human2.02384562
41E2F7_22180533_ChIP-Seq_HELA_Human10.1777711
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99753464
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.97626198
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96508400
45AR_21909140_ChIP-Seq_LNCAP_Human1.96350410
46* ETS1_20019798_ChIP-Seq_JURKAT_Human1.95872826
47XRN2_22483619_ChIP-Seq_HELA_Human1.92175661
48FOXP3_21729870_ChIP-Seq_TREG_Human1.91547837
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90747071
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88095302
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87971942
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85975626
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85101702
54ELK1_19687146_ChIP-ChIP_HELA_Human1.83413178
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83006322
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82114525
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77734147
58TTF2_22483619_ChIP-Seq_HELA_Human1.76375124
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75400248
60ER_23166858_ChIP-Seq_MCF-7_Human1.75315685
61IRF1_19129219_ChIP-ChIP_H3396_Human1.74321966
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70239329
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67280322
64DCP1A_22483619_ChIP-Seq_HELA_Human1.64028285
65* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61566302
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61118818
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60100838
68* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58738519
69* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58117207
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56865832
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56546195
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54578579
73BCAT_22108803_ChIP-Seq_LS180_Human1.52807375
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52511001
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.50955156
76GABP_19822575_ChIP-Seq_HepG2_Human1.50726074
77SMAD4_21799915_ChIP-Seq_A2780_Human1.50507613
78* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50504770
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50458205
80* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47688258
81* CBP_20019798_ChIP-Seq_JUKART_Human1.47688258
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47545139
83* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46604106
84SCL_19346495_ChIP-Seq_HPC-7_Human1.46600981
85KDM5A_27292631_Chip-Seq_BREAST_Human1.45664662
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44372236
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.43858943
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43461255
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43456715
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43062714
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41454901
92STAT3_23295773_ChIP-Seq_U87_Human1.41088328
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.40679591
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40550368
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39116229
96TCF4_23295773_ChIP-Seq_U87_Human1.34952791
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34351695
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34215429
99* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32206522
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.31485168
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31245919
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31086598
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30791379
104* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30779242
105* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29730729
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29545805
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29295245
108EZH2_22144423_ChIP-Seq_EOC_Human1.29075785
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28931303
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28630007
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28346431
112AR_25329375_ChIP-Seq_VCAP_Human1.28292827
113TCF4_22108803_ChIP-Seq_LS180_Human1.27500672
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27420916
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27420916
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.24997706
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23260826
118TP53_22573176_ChIP-Seq_HFKS_Human1.23032341
119NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21780576
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20402758
121* SOX2_19829295_ChIP-Seq_ESCs_Human1.20327201
122* NANOG_19829295_ChIP-Seq_ESCs_Human1.20327201
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19505723
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19287086
125* FLI1_21867929_ChIP-Seq_TH2_Mouse1.17952604
126* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17516641
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17493046
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15445346
129P53_22387025_ChIP-Seq_ESCs_Mouse1.14370834
130* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13520062
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12512342
132CDX2_22108803_ChIP-Seq_LS180_Human1.12079550
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.11894380
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11019274
135* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10822951
136MYB_26560356_Chip-Seq_TH2_Human1.10490426
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10101724
138RUNX2_22187159_ChIP-Seq_PCA_Human1.08782208
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07637021
140FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07302196
141SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05093461
142P300_18555785_Chip-Seq_ESCs_Mouse1.03809929
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.03241463
144TFEB_21752829_ChIP-Seq_HELA_Human1.03227748
145STAT3_18555785_Chip-Seq_ESCs_Mouse1.02525778
146* SPI1_23547873_ChIP-Seq_NB4_Human1.02254001
147RNF2_27304074_Chip-Seq_NSC_Mouse1.02233843
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01610067
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01364068
150* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00556030
151* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99503313
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.98438921
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97752198
154FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97709411
155SRF_21415370_ChIP-Seq_HL-1_Mouse0.96352036
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96113641
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95367387
158MYC_18940864_ChIP-ChIP_HL60_Human0.95016195
159MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94663163
160MYB_26560356_Chip-Seq_TH1_Human0.93746272
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93178846
162PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92034914
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90128605
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89221753
165* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87601471
166VDR_21846776_ChIP-Seq_THP-1_Human0.87368303
167YY1_21170310_ChIP-Seq_MESCs_Mouse0.87273084
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86759469
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86014697
170UTX_26944678_Chip-Seq_JUKART_Human0.86007845
171RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84989714
172EWS_26573619_Chip-Seq_HEK293_Human0.84764850
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84019570
174BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81105781
175SOX2_16153702_ChIP-ChIP_HESCs_Human0.79745079
176* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79040749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.02522009
2MP0008058_abnormal_DNA_repair3.90823386
3MP0003111_abnormal_nucleus_morphology3.85567931
4MP0003693_abnormal_embryo_hatching3.74168023
5MP0008057_abnormal_DNA_replication3.71025999
6MP0002396_abnormal_hematopoietic_system3.54907588
7MP0004957_abnormal_blastocyst_morpholog3.53316851
8MP0003077_abnormal_cell_cycle3.51968187
9MP0000372_irregular_coat_pigmentation3.24878275
10MP0008007_abnormal_cellular_replicative3.20508090
11MP0008877_abnormal_DNA_methylation3.20314915
12MP0000566_synostosis2.96999933
13MP0002638_abnormal_pupillary_reflex2.63135568
14MP0003646_muscle_fatigue2.58056885
15MP0006072_abnormal_retinal_apoptosis2.51021028
16MP0003763_abnormal_thymus_physiology2.39515153
17MP0004808_abnormal_hematopoietic_stem2.35524823
18MP0005075_abnormal_melanosome_morpholog2.21292865
19MP0000350_abnormal_cell_proliferation2.04107862
20MP0003880_abnormal_central_pattern2.03250108
21MP0005646_abnormal_pituitary_gland2.01641845
22MP0003123_paternal_imprinting1.98276350
23MP0005253_abnormal_eye_physiology1.96631102
24MP0003121_genomic_imprinting1.90988043
25MP0003787_abnormal_imprinting1.89971491
26MP0005551_abnormal_eye_electrophysiolog1.85521097
27MP0001730_embryonic_growth_arrest1.85317453
28MP0002837_dystrophic_cardiac_calcinosis1.83811162
29MP0006054_spinal_hemorrhage1.73073179
30MP0008932_abnormal_embryonic_tissue1.69621516
31MP0000703_abnormal_thymus_morphology1.69609626
32MP0000631_abnormal_neuroendocrine_gland1.64436851
33MP0002398_abnormal_bone_marrow1.62527299
34MP0003786_premature_aging1.62369114
35MP0000427_abnormal_hair_cycle1.62096410
36MP0000383_abnormal_hair_follicle1.61920844
37MP0001697_abnormal_embryo_size1.58857460
38MP0001984_abnormal_olfaction1.57137149
39MP0003195_calcinosis1.55492479
40MP0004215_abnormal_myocardial_fiber1.54583185
41MP0000490_abnormal_crypts_of1.51972923
42MP0005380_embryogenesis_phenotype1.50950315
43MP0001672_abnormal_embryogenesis/_devel1.50950315
44MP0008789_abnormal_olfactory_epithelium1.50923328
45MP0005645_abnormal_hypothalamus_physiol1.50096763
46MP0008872_abnormal_physiological_respon1.48202098
47MP0010352_gastrointestinal_tract_polyps1.45680513
48MP0000313_abnormal_cell_death1.43745697
49MP0004142_abnormal_muscle_tone1.41060607
50MP0003984_embryonic_growth_retardation1.40655848
51MP0002088_abnormal_embryonic_growth/wei1.40070427
52MP0002019_abnormal_tumor_incidence1.38830443
53MP0009697_abnormal_copulation1.38027686
54MP0010307_abnormal_tumor_latency1.36715109
55MP0002722_abnormal_immune_system1.35353884
56MP0000689_abnormal_spleen_morphology1.35059145
57MP0002751_abnormal_autonomic_nervous1.34911439
58MP0001986_abnormal_taste_sensitivity1.34807082
59MP0003890_abnormal_embryonic-extraembry1.33187534
60MP0002085_abnormal_embryonic_tissue1.31571999
61MP0001873_stomach_inflammation1.29911312
62MP0004147_increased_porphyrin_level1.29308540
63MP0002084_abnormal_developmental_patter1.28694584
64MP0005671_abnormal_response_to1.24315208
65MP0002080_prenatal_lethality1.23834201
66MP0006292_abnormal_olfactory_placode1.23677522
67MP0002086_abnormal_extraembryonic_tissu1.19924605
68MP0003943_abnormal_hepatobiliary_system1.17096472
69MP0001800_abnormal_humoral_immune1.15835365
70MP0002210_abnormal_sex_determination1.15604690
71MP0001529_abnormal_vocalization1.14283286
72MP0003941_abnormal_skin_development1.13174069
73MP0006276_abnormal_autonomic_nervous1.12123514
74MP0005499_abnormal_olfactory_system1.12079695
75MP0005394_taste/olfaction_phenotype1.12079695
76MP0000716_abnormal_immune_system1.12029667
77MP0002429_abnormal_blood_cell1.11400167
78MP0002166_altered_tumor_susceptibility1.11016848
79MP0005367_renal/urinary_system_phenotyp1.10693554
80MP0000516_abnormal_urinary_system1.10693554
81MP0001485_abnormal_pinna_reflex1.09135851
82MP0004197_abnormal_fetal_growth/weight/1.06193651
83MP0010030_abnormal_orbit_morphology1.05210219
84MP0002095_abnormal_skin_pigmentation1.04756907
85MP0001324_abnormal_eye_pigmentation1.04296255
86MP0003136_yellow_coat_color1.03560496
87MP0000647_abnormal_sebaceous_gland1.00183271
88MP0001929_abnormal_gametogenesis0.98934673
89MP0005389_reproductive_system_phenotype0.98841960
90MP0002277_abnormal_respiratory_mucosa0.98572917
91MP0002420_abnormal_adaptive_immunity0.98142702
92MP0001915_intracranial_hemorrhage0.96839406
93MP0001486_abnormal_startle_reflex0.96385151
94MP0001119_abnormal_female_reproductive0.96335172
95MP0001835_abnormal_antigen_presentation0.95942421
96MP0001145_abnormal_male_reproductive0.95545816
97MP0004264_abnormal_extraembryonic_tissu0.94739824
98MP0001819_abnormal_immune_cell0.94373581
99MP0009046_muscle_twitch0.94279225
100MP0010678_abnormal_skin_adnexa0.93990687
101MP0005391_vision/eye_phenotype0.93697053
102MP0002163_abnormal_gland_morphology0.93637721
103MP0005397_hematopoietic_system_phenotyp0.93593242
104MP0001545_abnormal_hematopoietic_system0.93593242
105MP0003567_abnormal_fetal_cardiomyocyte0.92837613
106MP0002938_white_spotting0.92500734
107MP0002452_abnormal_antigen_presenting0.91483108
108MP0002006_tumorigenesis0.89931383
109MP0001293_anophthalmia0.89001204
110MP0002736_abnormal_nociception_after0.88982952
111MP0000653_abnormal_sex_gland0.88888383
112MP0004133_heterotaxia0.88512571
113MP0002132_abnormal_respiratory_system0.87891436
114MP0002272_abnormal_nervous_system0.87742260
115MP0005195_abnormal_posterior_eye0.86967794
116MP0002876_abnormal_thyroid_physiology0.86776959
117MP0008775_abnormal_heart_ventricle0.86604937
118MP0001764_abnormal_homeostasis0.86533447
119MP0000015_abnormal_ear_pigmentation0.84850540
120MP0005076_abnormal_cell_differentiation0.84799183
121MP0001968_abnormal_touch/_nociception0.83616570
122MP0002405_respiratory_system_inflammati0.83504029
123MP0002233_abnormal_nose_morphology0.83254832
124MP0002928_abnormal_bile_duct0.81762341
125MP0000685_abnormal_immune_system0.81559016
126MP0003119_abnormal_digestive_system0.81436133
127MP0002752_abnormal_somatic_nervous0.77747262
128MP0006035_abnormal_mitochondrial_morpho0.76959656
129MP0000778_abnormal_nervous_system0.76445322
130MP0003698_abnormal_male_reproductive0.75516884
131MP0010386_abnormal_urinary_bladder0.75398033
132MP0001919_abnormal_reproductive_system0.75054960
133MP0009333_abnormal_splenocyte_physiolog0.74959041
134MP0001501_abnormal_sleep_pattern0.74713056
135MP0004885_abnormal_endolymph0.74362861
136MP0001188_hyperpigmentation0.74154624
137MP0005084_abnormal_gallbladder_morpholo0.73879239
138MP0001286_abnormal_eye_development0.73753126
139MP0002282_abnormal_trachea_morphology0.73386763
140MP0000465_gastrointestinal_hemorrhage0.73168279
141MP0002933_joint_inflammation0.72713763
142MP0009745_abnormal_behavioral_response0.72360998
143MP0003315_abnormal_perineum_morphology0.72321453
144MP0005386_behavior/neurological_phenoty0.71194725
145MP0004924_abnormal_behavior0.71194725
146MP0002723_abnormal_immune_serum0.70831521
147MP0002102_abnormal_ear_morphology0.70389883
148MP0005379_endocrine/exocrine_gland_phen0.69491818
149MP0003252_abnormal_bile_duct0.69426897
150MP0008995_early_reproductive_senescence0.69305598
151MP0003937_abnormal_limbs/digits/tail_de0.67522296
152MP0005409_darkened_coat_color0.67231546
153MP0005174_abnormal_tail_pigmentation0.66795731
154MP0002092_abnormal_eye_morphology0.66209874
155MP0002009_preneoplasia0.65936464
156MP0000569_abnormal_digit_pigmentation0.64464130
157MP0005384_cellular_phenotype0.64118032
158MP0003115_abnormal_respiratory_system0.62850375
159MP0002160_abnormal_reproductive_system0.61694883
160MP0000358_abnormal_cell_content/0.61187199
161MP0000428_abnormal_craniofacial_morphol0.60180655
162MP0009703_decreased_birth_body0.59164884
163MP0003718_maternal_effect0.59154852
164MP0000049_abnormal_middle_ear0.58290908
165MP0002925_abnormal_cardiovascular_devel0.57786581
166MP0010155_abnormal_intestine_physiology0.57352108

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)4.85045173
2Birth length less than 3rd percentile (HP:0003561)4.38133504
3IgM deficiency (HP:0002850)4.29985970
4Selective tooth agenesis (HP:0001592)4.28864017
5Pancreatic cysts (HP:0001737)3.85087173
6Chromsome breakage (HP:0040012)3.51934592
7Abnormality of midbrain morphology (HP:0002418)3.42956048
8Molar tooth sign on MRI (HP:0002419)3.42956048
9Urethral obstruction (HP:0000796)3.42013320
10Abnormality of chromosome stability (HP:0003220)3.40313654
11Pancreatic fibrosis (HP:0100732)3.35069178
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22141298
13High pitched voice (HP:0001620)3.21915270
14Abnormality of the preputium (HP:0100587)3.20413657
15Nephronophthisis (HP:0000090)3.18214873
16True hermaphroditism (HP:0010459)3.14818554
17Abnormal number of incisors (HP:0011064)3.11869663
18Volvulus (HP:0002580)3.09191075
19Medial flaring of the eyebrow (HP:0010747)3.08710075
20Myelodysplasia (HP:0002863)2.96018198
21Abnormality of the renal medulla (HP:0100957)2.91338453
22Squamous cell carcinoma (HP:0002860)2.89950518
23Abnormality of the renal cortex (HP:0011035)2.83860688
24Aplastic anemia (HP:0001915)2.82150930
25Abnormality of B cell number (HP:0010975)2.80240028
26B lymphocytopenia (HP:0010976)2.80240028
27Patellar aplasia (HP:0006443)2.78092677
28Acute myeloid leukemia (HP:0004808)2.77397615
29Prominent nose (HP:0000448)2.73624331
30Abnormality of the fingertips (HP:0001211)2.73476377
31Medulloblastoma (HP:0002885)2.66023682
32Short 4th metacarpal (HP:0010044)2.63784775
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63784775
3411 pairs of ribs (HP:0000878)2.61349638
35Reticulocytopenia (HP:0001896)2.59848186
36IgG deficiency (HP:0004315)2.59125135
37Meckel diverticulum (HP:0002245)2.57515009
38Congenital, generalized hypertrichosis (HP:0004540)2.56778131
39Abolished electroretinogram (ERG) (HP:0000550)2.55821688
40Congenital primary aphakia (HP:0007707)2.55805080
41Lymphoma (HP:0002665)2.54521573
42Aplasia/Hypoplasia of the patella (HP:0006498)2.54366405
43Renal cortical cysts (HP:0000803)2.51805454
44Thyroiditis (HP:0100646)2.51245012
45Bone marrow hypocellularity (HP:0005528)2.51079557
46Thrombocytosis (HP:0001894)2.50362576
47Gait imbalance (HP:0002141)2.49752639
48Abnormality of the ileum (HP:0001549)2.48625135
49Abnormal biliary tract physiology (HP:0012439)2.48223788
50Bile duct proliferation (HP:0001408)2.48223788
51Intestinal atresia (HP:0011100)2.48068318
52Colon cancer (HP:0003003)2.47101934
53Breast hypoplasia (HP:0003187)2.46838128
54Rough bone trabeculation (HP:0100670)2.43779575
55Increased nuchal translucency (HP:0010880)2.41686487
56Nephrogenic diabetes insipidus (HP:0009806)2.39317828
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.38766736
58Methylmalonic acidemia (HP:0002912)2.36415978
59Chronic hepatic failure (HP:0100626)2.34395090
60Hypothermia (HP:0002045)2.33750059
61Congenital stationary night blindness (HP:0007642)2.33602214
62Fair hair (HP:0002286)2.28181214
63Premature graying of hair (HP:0002216)2.27834290
64Abnormality of the renal collecting system (HP:0004742)2.23653104
65Facial hemangioma (HP:0000329)2.23359795
66Abnormal spermatogenesis (HP:0008669)2.23070599
67Degeneration of anterior horn cells (HP:0002398)2.22538656
68Abnormality of the anterior horn cell (HP:0006802)2.22538656
69Genital tract atresia (HP:0001827)2.21574786
70Panhypogammaglobulinemia (HP:0003139)2.19807785
71T lymphocytopenia (HP:0005403)2.19667016
72Duplicated collecting system (HP:0000081)2.17809745
73Abnormal lung lobation (HP:0002101)2.15753095
74Vaginal atresia (HP:0000148)2.15632688
75Abnormality of the incisor (HP:0000676)2.14697280
76Cystic liver disease (HP:0006706)2.13793684
77Cellular immunodeficiency (HP:0005374)2.13306845
78Hyperventilation (HP:0002883)2.13298303
79Sloping forehead (HP:0000340)2.13034225
80Small intestinal stenosis (HP:0012848)2.11488725
81Duodenal stenosis (HP:0100867)2.11488725
82Abnormality of alanine metabolism (HP:0010916)2.11221140
83Hyperalaninemia (HP:0003348)2.11221140
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11221140
85Abnormality of the labia minora (HP:0012880)2.07492045
86IgA deficiency (HP:0002720)2.07431512
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.07112539
88Recurrent viral infections (HP:0004429)2.03974483
89Acute necrotizing encephalopathy (HP:0006965)2.03366907
90Severe combined immunodeficiency (HP:0004430)2.02656432
91Atrophy/Degeneration involving motor neurons (HP:0007373)2.02624559
92Progressive macrocephaly (HP:0004481)2.00614112
93Blepharitis (HP:0000498)1.99995466
94Broad palm (HP:0001169)1.98794387
95Poor coordination (HP:0002370)1.98449908
96Attenuation of retinal blood vessels (HP:0007843)1.98021758
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.97897179
98Atresia of the external auditory canal (HP:0000413)1.96582526
99Neoplasm of the pancreas (HP:0002894)1.96088080
100Broad-based gait (HP:0002136)1.95714907
101Bifid tongue (HP:0010297)1.95697686
102Amaurosis fugax (HP:0100576)1.95362410
103Trigonocephaly (HP:0000243)1.94256259
104Ectopic kidney (HP:0000086)1.93887682
105Abnormal rod and cone electroretinograms (HP:0008323)1.93803289
106Abnormality of T cell number (HP:0011839)1.93545553
107Absent thumb (HP:0009777)1.93235800
108Increased CSF lactate (HP:0002490)1.92931086
109Rhabdomyosarcoma (HP:0002859)1.92206540
110Acute encephalopathy (HP:0006846)1.89034513
111Cafe-au-lait spot (HP:0000957)1.89027570
112Mitochondrial inheritance (HP:0001427)1.89024389
113Gaze-evoked nystagmus (HP:0000640)1.88168741
114Shoulder girdle muscle weakness (HP:0003547)1.87218117
115Pulmonary fibrosis (HP:0002206)1.86113104
116Anencephaly (HP:0002323)1.85936214
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.85870557
118Oligodactyly (hands) (HP:0001180)1.85703953
119Sclerocornea (HP:0000647)1.84640468
120Hypoplasia of the thymus (HP:0000778)1.84166091
121Amyotrophic lateral sclerosis (HP:0007354)1.83478610
122Abnormality of cells of the erythroid lineage (HP:0012130)1.83313747
123Basal cell carcinoma (HP:0002671)1.83281528
124Pendular nystagmus (HP:0012043)1.82871689
125Abnormality of the carotid arteries (HP:0005344)1.82727100
126Long eyelashes (HP:0000527)1.81948133
127Teleangiectasia of the skin (HP:0100585)1.81770687
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.81440750
129Astigmatism (HP:0000483)1.81383875
130Postaxial foot polydactyly (HP:0001830)1.81243968
131Progressive inability to walk (HP:0002505)1.81213302
132Congenital hepatic fibrosis (HP:0002612)1.80616767
133Combined immunodeficiency (HP:0005387)1.80526817
134Ependymoma (HP:0002888)1.79527582
135Postaxial hand polydactyly (HP:0001162)1.79089480
136Male pseudohermaphroditism (HP:0000037)1.78514202
137Stomach cancer (HP:0012126)1.76810156
138Tubular atrophy (HP:0000092)1.75627341
139Methylmalonic aciduria (HP:0012120)1.75343630
140Abnormality of T cells (HP:0002843)1.75261442
141Stenosis of the external auditory canal (HP:0000402)1.75113436
142Carpal bone hypoplasia (HP:0001498)1.74817735
143Sparse lateral eyebrow (HP:0005338)1.74560087
144Abnormality of the duodenum (HP:0002246)1.73585954
145Proximal placement of thumb (HP:0009623)1.73578608
146Dandy-Walker malformation (HP:0001305)1.73088074
147Neoplasm of the adrenal cortex (HP:0100641)1.73078424
148Abnormality of the columella (HP:0009929)1.72955629
1493-Methylglutaconic aciduria (HP:0003535)1.72949638
150Hypoproteinemia (HP:0003075)1.72665169
151Genetic anticipation (HP:0003743)1.72516290
152Preaxial hand polydactyly (HP:0001177)1.72413874
153Abnormal trabecular bone morphology (HP:0100671)1.71096291
154Azoospermia (HP:0000027)1.69915277
155Heterotopia (HP:0002282)1.69574214
156Lipid accumulation in hepatocytes (HP:0006561)1.69254254
157Hypoplastic labia majora (HP:0000059)1.68930681
158Inability to walk (HP:0002540)1.68698041
159Small hand (HP:0200055)1.68378578
160Furrowed tongue (HP:0000221)1.68350392
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67557179
162Asplenia (HP:0001746)1.67365679
163Deviation of the thumb (HP:0009603)1.66624381
164Abnormality of the 4th metacarpal (HP:0010012)1.66001226
165Hepatocellular necrosis (HP:0001404)1.65666715
166Chorioretinal atrophy (HP:0000533)1.65170056
167Deep philtrum (HP:0002002)1.64104166
168Progressive cerebellar ataxia (HP:0002073)1.63475332
169Agnosia (HP:0010524)1.63367616
170Oligohydramnios (HP:0001562)1.63288025
171Pelvic girdle muscle weakness (HP:0003749)1.63100705
172Clubbing of toes (HP:0100760)1.63020512
173Abnormal mitochondria in muscle tissue (HP:0008316)1.62478178
174Tracheoesophageal fistula (HP:0002575)1.62472574
175Increased hepatocellular lipid droplets (HP:0006565)1.61958143
176Tubulointerstitial nephritis (HP:0001970)1.61955128
177Specific learning disability (HP:0001328)1.61611476
178Supernumerary spleens (HP:0009799)1.61552745
179Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60946417
180Impulsivity (HP:0100710)1.60599652
181Neoplasm of the oral cavity (HP:0100649)1.60249164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.47847100
2CDC74.39427833
3MKNK24.25446913
4MKNK13.51424108
5MAP4K23.29067659
6NEK23.11923771
7ACVR1B2.95724114
8TGFBR12.92914387
9TTK2.89982553
10WEE12.87413218
11TSSK62.62252523
12BUB12.51774670
13MAP3K102.50255931
14WNK32.32797469
15SRPK12.30187126
16TRIM282.16214554
17BMPR1B2.03420398
18STK162.02223210
19MAP3K41.94231788
20MAP4K11.91244038
21* ATR1.85869664
22CDK81.85392602
23CCNB11.72542760
24GRK11.68627833
25PASK1.64675560
26EEF2K1.60753423
27MST41.60540859
28PLK31.53567640
29PLK11.49445150
30VRK11.48539001
31RPS6KB21.48457474
32STK101.47281217
33PINK11.46724964
34BRD41.46472504
35BRSK21.46160281
36TAOK31.45057382
37ADRBK21.40528643
38AURKB1.39998992
39STK38L1.28995940
40STK391.26781287
41CHEK21.25572412
42INSRR1.25433890
43MAPK131.24955872
44EIF2AK11.21670315
45AKT31.20444609
46CASK1.19182846
47FGFR31.18977655
48OXSR11.18812721
49CHEK11.14793502
50SIK31.14372424
51CDK71.13940020
52CDK121.13269357
53JAK31.11860006
54PLK41.11101437
55LATS11.10158238
56ATM1.10145442
57PNCK1.10046571
58TXK1.09301348
59CDK41.06822985
60EIF2AK31.06526827
61FLT31.03840630
62MELK1.01976755
63CDK91.00582531
64NEK10.97260092
65PAK30.95981132
66PAK40.94935526
67BCR0.92697061
68DYRK30.92189960
69BMPR20.91965850
70BRAF0.91917175
71MAP3K80.90121263
72STK40.85883861
73MAP3K60.84418285
74BTK0.81761702
75PLK20.81433437
76MAP2K70.80663438
77CSNK1G10.80119692
78ZAK0.79968154
79STK30.75876906
80CDK20.75155340
81FGFR20.72706958
82TLK10.72218166
83PRKCE0.72145202
84RPS6KA40.72105129
85BRSK10.71311655
86WNK40.70843697
87CSNK1G20.70582956
88CSF1R0.67986887
89PDK20.67402015
90CDK60.67074401
91CDK10.66762876
92FGFR10.66175814
93CAMKK20.65174595
94STK240.64765865
95TNIK0.64600962
96ZAP700.64051652
97PIM10.63675802
98TIE10.63377175
99PIK3CA0.62781815
100CDK190.62427142
101EIF2AK20.62111163
102YES10.61785153
103ERBB30.61371149
104NLK0.60867727
105CLK10.60679986
106OBSCN0.58849645
107TEC0.58424138
108DYRK20.57824647
109CSNK1G30.57593667
110TAF10.55229022
111KIT0.55014994
112MUSK0.54785273
113PIK3CG0.53423145
114EPHA40.50845371
115PBK0.48514313
116BLK0.47868372
117SYK0.47610041
118DYRK1B0.47117049
119TAOK20.46192243
120ADRBK10.45062243
121NUAK10.42156739
122ERBB20.41830262
123AURKA0.41776086
124LCK0.41472826
125MAPK140.38663841
126DYRK1A0.37995332
127CHUK0.36710671
128VRK20.36181307
129PRKCQ0.35507646
130CSNK1A1L0.34960487
131LRRK20.33832513
132MAP3K50.33318962
133PRKACA0.32474259
134LYN0.32161407
135CSNK2A20.32144126
136EGFR0.32114222
137PKN10.31942050
138RPS6KB10.31821354
139ITK0.31630991
140ALK0.31416718
141HIPK20.31162223
142IGF1R0.31066586
143MARK30.31037636
144CSNK2A10.30599960
145TGFBR20.29686057
146CDK30.29536775
147MAP3K120.27521378
148RPS6KA50.26444978
149GRK60.25572433
150AKT10.24554829
151MAPK80.21977249
152SGK20.21646404

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60234377
2Mismatch repair_Homo sapiens_hsa034304.31935628
3Base excision repair_Homo sapiens_hsa034103.41647032
4Homologous recombination_Homo sapiens_hsa034403.33349573
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26829564
6Cell cycle_Homo sapiens_hsa041103.21735912
7Spliceosome_Homo sapiens_hsa030403.19195100
8RNA transport_Homo sapiens_hsa030132.90402225
9Non-homologous end-joining_Homo sapiens_hsa034502.79932857
10Protein export_Homo sapiens_hsa030602.78556560
11Fanconi anemia pathway_Homo sapiens_hsa034602.71188476
12Nucleotide excision repair_Homo sapiens_hsa034202.70518681
13Phototransduction_Homo sapiens_hsa047442.21753727
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17951072
15Oxidative phosphorylation_Homo sapiens_hsa001902.13597174
16* RNA degradation_Homo sapiens_hsa030182.09025057
17RNA polymerase_Homo sapiens_hsa030201.99535686
18Primary immunodeficiency_Homo sapiens_hsa053401.98467593
19p53 signaling pathway_Homo sapiens_hsa041151.91860446
20Pyrimidine metabolism_Homo sapiens_hsa002401.90486811
21Ribosome_Homo sapiens_hsa030101.89265015
22mRNA surveillance pathway_Homo sapiens_hsa030151.88635604
23Parkinsons disease_Homo sapiens_hsa050121.82853047
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82229568
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79974072
26Linoleic acid metabolism_Homo sapiens_hsa005911.79162666
27One carbon pool by folate_Homo sapiens_hsa006701.74587909
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71750695
29Nitrogen metabolism_Homo sapiens_hsa009101.71202351
30Basal transcription factors_Homo sapiens_hsa030221.70461795
31Asthma_Homo sapiens_hsa053101.70139694
32Propanoate metabolism_Homo sapiens_hsa006401.68308949
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60160537
34Proteasome_Homo sapiens_hsa030501.48541334
35Regulation of autophagy_Homo sapiens_hsa041401.47400755
36Ether lipid metabolism_Homo sapiens_hsa005651.39214551
37Butanoate metabolism_Homo sapiens_hsa006501.32858219
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32622579
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32157506
40Herpes simplex infection_Homo sapiens_hsa051681.30907436
41Huntingtons disease_Homo sapiens_hsa050161.29475537
42Antigen processing and presentation_Homo sapiens_hsa046121.28205887
43Caffeine metabolism_Homo sapiens_hsa002321.26311131
44Epstein-Barr virus infection_Homo sapiens_hsa051691.24319957
45Systemic lupus erythematosus_Homo sapiens_hsa053221.23577417
46Nicotine addiction_Homo sapiens_hsa050331.20091185
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18544740
48Viral carcinogenesis_Homo sapiens_hsa052031.17828153
49Purine metabolism_Homo sapiens_hsa002301.16594031
50HTLV-I infection_Homo sapiens_hsa051661.16406629
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14479555
52Tryptophan metabolism_Homo sapiens_hsa003801.14230251
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10331225
54Oocyte meiosis_Homo sapiens_hsa041141.08556650
55Colorectal cancer_Homo sapiens_hsa052101.06478454
56Graft-versus-host disease_Homo sapiens_hsa053321.05150662
57Type I diabetes mellitus_Homo sapiens_hsa049400.97807547
58Olfactory transduction_Homo sapiens_hsa047400.97433491
59MicroRNAs in cancer_Homo sapiens_hsa052060.93985781
60Measles_Homo sapiens_hsa051620.91825584
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.91799885
62Alzheimers disease_Homo sapiens_hsa050100.90793375
63Peroxisome_Homo sapiens_hsa041460.87615554
64Cardiac muscle contraction_Homo sapiens_hsa042600.87442290
65Hepatitis B_Homo sapiens_hsa051610.85558678
66Taste transduction_Homo sapiens_hsa047420.84140820
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84017730
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82364423
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82006052
70Notch signaling pathway_Homo sapiens_hsa043300.81043738
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80719684
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.79356889
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78569297
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78537796
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76182648
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.75797423
77Hematopoietic cell lineage_Homo sapiens_hsa046400.74050266
78B cell receptor signaling pathway_Homo sapiens_hsa046620.73778376
79Chemical carcinogenesis_Homo sapiens_hsa052040.73610464
80Small cell lung cancer_Homo sapiens_hsa052220.73400016
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.72435618
82T cell receptor signaling pathway_Homo sapiens_hsa046600.69949449
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69698139
84Morphine addiction_Homo sapiens_hsa050320.67313644
85Legionellosis_Homo sapiens_hsa051340.65403134
86Pancreatic cancer_Homo sapiens_hsa052120.65015914
87Chronic myeloid leukemia_Homo sapiens_hsa052200.64688174
88Fatty acid elongation_Homo sapiens_hsa000620.62657534
89Thyroid cancer_Homo sapiens_hsa052160.61964776
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59707474
91TGF-beta signaling pathway_Homo sapiens_hsa043500.59203298
92Non-small cell lung cancer_Homo sapiens_hsa052230.59192991
93Retinol metabolism_Homo sapiens_hsa008300.59182374
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58096782
95Influenza A_Homo sapiens_hsa051640.57902165
96Apoptosis_Homo sapiens_hsa042100.57654321
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56874494
98Basal cell carcinoma_Homo sapiens_hsa052170.55335629
99Steroid biosynthesis_Homo sapiens_hsa001000.55335346
100Selenocompound metabolism_Homo sapiens_hsa004500.53473187
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.52939173
102Viral myocarditis_Homo sapiens_hsa054160.52547481
103Shigellosis_Homo sapiens_hsa051310.51198309
104Vitamin digestion and absorption_Homo sapiens_hsa049770.50972635
105FoxO signaling pathway_Homo sapiens_hsa040680.50467026
106Serotonergic synapse_Homo sapiens_hsa047260.49539984
107Hippo signaling pathway_Homo sapiens_hsa043900.49270338
108Prostate cancer_Homo sapiens_hsa052150.48510869
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48323555
110Alcoholism_Homo sapiens_hsa050340.48199565
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48085439
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.47881121
113Pathways in cancer_Homo sapiens_hsa052000.47521484
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47373354
115N-Glycan biosynthesis_Homo sapiens_hsa005100.47259303
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47111250
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46183247
118Lysine degradation_Homo sapiens_hsa003100.46154247
119Adherens junction_Homo sapiens_hsa045200.45037170
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44528908
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44512783
122ABC transporters_Homo sapiens_hsa020100.44431118
123Endometrial cancer_Homo sapiens_hsa052130.43683093
124Metabolic pathways_Homo sapiens_hsa011000.43549057
125Acute myeloid leukemia_Homo sapiens_hsa052210.43225933
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.42979968
127Wnt signaling pathway_Homo sapiens_hsa043100.42917068
128GABAergic synapse_Homo sapiens_hsa047270.40560386
129Arachidonic acid metabolism_Homo sapiens_hsa005900.40474383
130mTOR signaling pathway_Homo sapiens_hsa041500.40115027
131Circadian entrainment_Homo sapiens_hsa047130.39386931
132Circadian rhythm_Homo sapiens_hsa047100.39278536
133Sulfur metabolism_Homo sapiens_hsa009200.39114267
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37782832
135Toxoplasmosis_Homo sapiens_hsa051450.36122485
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34525356
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34207500
138Collecting duct acid secretion_Homo sapiens_hsa049660.33770732
139Dorso-ventral axis formation_Homo sapiens_hsa043200.33397908
140Glutamatergic synapse_Homo sapiens_hsa047240.32849644
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32715297
142Bladder cancer_Homo sapiens_hsa052190.31642784
143Salivary secretion_Homo sapiens_hsa049700.31476678
144HIF-1 signaling pathway_Homo sapiens_hsa040660.31421722
145Leishmaniasis_Homo sapiens_hsa051400.31404672
146Fatty acid degradation_Homo sapiens_hsa000710.31365071
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.30466312
148Melanoma_Homo sapiens_hsa052180.29115152
149TNF signaling pathway_Homo sapiens_hsa046680.26756391
150Autoimmune thyroid disease_Homo sapiens_hsa053200.25780942
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.24377918
152Allograft rejection_Homo sapiens_hsa053300.24146477
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24044319
154Prolactin signaling pathway_Homo sapiens_hsa049170.23920836
155Osteoclast differentiation_Homo sapiens_hsa043800.23638346
156Hedgehog signaling pathway_Homo sapiens_hsa043400.23539113
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21113013
158Platelet activation_Homo sapiens_hsa046110.19305392

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