CNOT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.74074577
2pre-miRNA processing (GO:0031054)4.54231910
3heterochromatin organization (GO:0070828)4.01242099
4regulation of NFAT protein import into nucleus (GO:0051532)3.94747761
5nuclear pore complex assembly (GO:0051292)3.92465003
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.86093151
7nuclear pore organization (GO:0006999)3.81190234
8protein localization to kinetochore (GO:0034501)3.73995228
9DNA unwinding involved in DNA replication (GO:0006268)3.72079753
10mitotic sister chromatid segregation (GO:0000070)3.67595977
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.59891430
12regulation of chromatin binding (GO:0035561)3.57402888
13regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56695623
14histone H4-K12 acetylation (GO:0043983)3.55602951
15negative regulation of RNA splicing (GO:0033119)3.52696827
16regulation of histone H3-K27 methylation (GO:0061085)3.50957459
17negative regulation of mRNA processing (GO:0050686)3.48332125
18negative regulation of histone methylation (GO:0031061)3.47526896
19sister chromatid segregation (GO:0000819)3.44867631
20mitotic nuclear envelope disassembly (GO:0007077)3.44007434
21dosage compensation (GO:0007549)3.39635184
22negative regulation of cell size (GO:0045792)3.38202475
23intracellular estrogen receptor signaling pathway (GO:0030520)3.38092105
24protein localization to chromosome, centromeric region (GO:0071459)3.37374577
25mRNA stabilization (GO:0048255)3.36489585
26RNA stabilization (GO:0043489)3.36489585
27Golgi transport vesicle coating (GO:0048200)3.36118085
28COPI coating of Golgi vesicle (GO:0048205)3.36118085
29apoptotic process involved in morphogenesis (GO:0060561)3.36039037
30activation of Rac GTPase activity (GO:0032863)3.30799994
31positive regulation of gene expression, epigenetic (GO:0045815)3.29561036
32regulation of gene silencing by RNA (GO:0060966)3.29482711
33regulation of posttranscriptional gene silencing (GO:0060147)3.29482711
34regulation of gene silencing by miRNA (GO:0060964)3.29482711
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.29011625
36adherens junction assembly (GO:0034333)3.26403772
37pore complex assembly (GO:0046931)3.23820851
38histone H3-K4 methylation (GO:0051568)3.20993181
39regulation of nucleobase-containing compound transport (GO:0032239)3.20632917
40modulation by virus of host process (GO:0019054)3.20586563
41cell-substrate adherens junction assembly (GO:0007045)3.20509452
42focal adhesion assembly (GO:0048041)3.20509452
43negative regulation of mRNA metabolic process (GO:1903312)3.16913729
44nuclear envelope disassembly (GO:0051081)3.13699493
45membrane disassembly (GO:0030397)3.13699493
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13601546
47cellular response to virus (GO:0098586)3.11735385
48modulation by symbiont of host cellular process (GO:0044068)3.11671323
49regulation of early endosome to late endosome transport (GO:2000641)3.11528189
50mitotic sister chromatid cohesion (GO:0007064)3.11472845
51paraxial mesoderm development (GO:0048339)3.09553485
52protein-DNA complex disassembly (GO:0032986)3.09415446
53nucleosome disassembly (GO:0006337)3.09415446
54regulation of histone H3-K9 methylation (GO:0051570)3.06006061
55DNA damage response, signal transduction resulting in transcription (GO:0042772)3.05068667
56mitotic chromosome condensation (GO:0007076)3.04337956
57positive regulation of Cdc42 GTPase activity (GO:0043089)3.00606286
58DNA duplex unwinding (GO:0032508)3.00385865
59protein localization to endosome (GO:0036010)2.99008574
60mannose metabolic process (GO:0006013)2.97587036
61DNA geometric change (GO:0032392)2.97224348
62regulation of translational fidelity (GO:0006450)2.97221965
63kinetochore organization (GO:0051383)2.97043923
64regulation of RNA export from nucleus (GO:0046831)2.96831365
65histone H3-K36 demethylation (GO:0070544)2.96098724
66embryonic process involved in female pregnancy (GO:0060136)2.91816573
67protein retention in ER lumen (GO:0006621)2.89079187
68chromatin assembly (GO:0031497)2.89008125
69glucocorticoid receptor signaling pathway (GO:0042921)2.88600775
70DNA replication initiation (GO:0006270)2.88570515
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88133648
72folic acid-containing compound biosynthetic process (GO:0009396)2.87594352
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87062101
74response to laminar fluid shear stress (GO:0034616)2.85429561
75pentose-phosphate shunt (GO:0006098)2.84628113
76DNA replication checkpoint (GO:0000076)2.83890970
77positive regulation of histone deacetylation (GO:0031065)2.83829877
783-UTR-mediated mRNA stabilization (GO:0070935)2.82281114
79maternal placenta development (GO:0001893)2.82266658
80DNA strand elongation involved in DNA replication (GO:0006271)2.79584620
81positive regulation of chromosome segregation (GO:0051984)2.79456623
82regulation of sister chromatid cohesion (GO:0007063)2.79105704
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78583163
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.78583163
85modulation by symbiont of host immune response (GO:0052553)2.78583163
86positive regulation by symbiont of host defense response (GO:0052509)2.78583163
87modulation by symbiont of host defense response (GO:0052031)2.78583163
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78583163
89kinetochore assembly (GO:0051382)2.78371869
90mitotic metaphase plate congression (GO:0007080)2.78146988
91negative regulation of viral release from host cell (GO:1902187)2.76381505
92histone H4-K5 acetylation (GO:0043981)2.76205325
93histone H4-K8 acetylation (GO:0043982)2.76205325
94regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75625680
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73319132
96response to muramyl dipeptide (GO:0032495)2.73219197
97histone H2A monoubiquitination (GO:0035518)2.73179101
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72548425
99regulation of histone H3-K4 methylation (GO:0051569)2.72041321
100RNA splicing, via transesterification reactions (GO:0000375)2.71593207
101mRNA splicing, via spliceosome (GO:0000398)2.70815615
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70815615
103viral transcription (GO:0019083)2.70506147
104response to peptidoglycan (GO:0032494)2.69648928
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.68462808
106DNA strand elongation (GO:0022616)2.67610870
107meiotic chromosome segregation (GO:0045132)2.67184752
108modulation by virus of host morphology or physiology (GO:0019048)2.66528857
109proline biosynthetic process (GO:0006561)2.66411731
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65477487
111regulation of telomere maintenance via telomerase (GO:0032210)2.65051403
112regulation of mRNA stability (GO:0043488)2.64481627
113histone H3 acetylation (GO:0043966)2.63293562
114histone H3-K4 trimethylation (GO:0080182)2.62996090
115telomere maintenance via semi-conservative replication (GO:0032201)2.61346368
116protein localization to chromosome (GO:0034502)2.61201661
117positive regulation of mitotic sister chromatid separation (GO:1901970)2.60998497
118positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60998497
119positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60998497
120nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59723535
121inner cell mass cell proliferation (GO:0001833)2.59116552
122stress fiber assembly (GO:0043149)2.58507374
123translational termination (GO:0006415)2.57888701
124activation of MAPKKK activity (GO:0000185)2.57535423
125thymic T cell selection (GO:0045061)2.55632593
126histone H4-K16 acetylation (GO:0043984)2.55561938
127regulation of gene silencing (GO:0060968)2.55360370
128regulation of RNA stability (GO:0043487)2.55328229
129histone H4 deacetylation (GO:0070933)2.55234825
130chromatin assembly or disassembly (GO:0006333)2.55187262
131epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55003296
132alternative mRNA splicing, via spliceosome (GO:0000380)2.54035439
133mRNA transport (GO:0051028)2.54010770
134cellular response to epidermal growth factor stimulus (GO:0071364)2.53453673
135termination of RNA polymerase II transcription (GO:0006369)2.52358905
136regulation of spindle organization (GO:0090224)2.51446521
137negative regulation of myotube differentiation (GO:0010832)2.51163843
138regulation of mitotic spindle organization (GO:0060236)2.50661275
139metaphase plate congression (GO:0051310)2.50085000
140positive regulation of DNA-dependent DNA replication (GO:2000105)2.49851957
141semaphorin-plexin signaling pathway (GO:0071526)2.49727231
142NIK/NF-kappaB signaling (GO:0038061)2.49521843
143positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49520550
144DNA replication-dependent nucleosome organization (GO:0034723)2.49268374
145DNA replication-dependent nucleosome assembly (GO:0006335)2.49268374
146nuclear envelope organization (GO:0006998)2.49099348
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.48791392
148negative regulation of gene expression, epigenetic (GO:0045814)2.48511326
149regulation of nuclear cell cycle DNA replication (GO:0033262)2.48455494
150DNA conformation change (GO:0071103)2.48059432
151spliceosomal tri-snRNP complex assembly (GO:0000244)2.46650678
152peptidyl-arginine omega-N-methylation (GO:0035247)2.46354344
153positive regulation of gamma-delta T cell activation (GO:0046645)2.46193297
154formation of translation preinitiation complex (GO:0001731)2.46158193
155positive regulation of SMAD protein import into nucleus (GO:0060391)2.46071533
156histone methylation (GO:0016571)2.46038406
157regulation of ARF GTPase activity (GO:0032312)2.45897141
158IMP biosynthetic process (GO:0006188)2.45832766
159histone lysine demethylation (GO:0070076)2.45729231
160histone lysine methylation (GO:0034968)2.45633044
161glucose 6-phosphate metabolic process (GO:0051156)2.45592002
162positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.45574526
163* gene silencing (GO:0016458)2.44982587
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44943374
165corticosteroid receptor signaling pathway (GO:0031958)2.42241676
166histone demethylation (GO:0016577)2.39644089
167glucose catabolic process (GO:0006007)2.37517040
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37237173
169signal complex assembly (GO:0007172)2.37210896
170negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37064804
171negative regulation of cell killing (GO:0031342)2.37064804
172cell-substrate junction assembly (GO:0007044)2.36581586
173antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.33972890
174atrioventricular valve morphogenesis (GO:0003181)2.33800117
175snRNA metabolic process (GO:0016073)2.33771680
176positive regulation of protein deacetylation (GO:0090312)2.33000163
177positive regulation of nuclease activity (GO:0032075)2.31043987
178stress granule assembly (GO:0034063)2.30767012
179protein export from nucleus (GO:0006611)2.30620471
180positive thymic T cell selection (GO:0045059)2.27750008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12273174
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.18774122
3MYC_22102868_ChIP-Seq_BL_Human3.61633143
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20854183
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13512500
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.09051770
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.81605846
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.65837161
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52782878
10* VDR_21846776_ChIP-Seq_THP-1_Human2.44852786
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40417735
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31012241
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.26973882
14CIITA_25753668_ChIP-Seq_RAJI_Human2.16181353
15RACK7_27058665_Chip-Seq_MCF-7_Human2.14622103
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07648960
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97094994
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.89238030
19XRN2_22483619_ChIP-Seq_HELA_Human1.88486946
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88072503
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87848548
22TCF7_22412390_ChIP-Seq_EML_Mouse1.85599087
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84045999
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83472578
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77899971
26KDM2B_26808549_Chip-Seq_K562_Human1.74579437
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74302271
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74302271
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74302271
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70238005
31KDM2B_26808549_Chip-Seq_DND41_Human1.67666495
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66392704
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65318399
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64190462
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59459495
36UTX_26944678_Chip-Seq_JUKART_Human1.57560122
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56897740
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54815090
39* P68_20966046_ChIP-Seq_HELA_Human1.53278875
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50910991
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49127783
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48335292
43KDM5A_27292631_Chip-Seq_BREAST_Human1.48303570
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47819544
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47207695
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44988673
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44534546
48MAF_26560356_Chip-Seq_TH1_Human1.43466230
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.41248582
50* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40129912
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.39125028
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.39122858
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39116447
54CREB1_26743006_Chip-Seq_LNCaP_Human1.38817436
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38554192
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37130655
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36314428
58ZNF263_19887448_ChIP-Seq_K562_Human1.35936563
59SCL_19346495_ChIP-Seq_HPC-7_Human1.35814120
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35531991
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35483488
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34417396
63* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34200889
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33433053
65SMC4_20622854_ChIP-Seq_HELA_Human1.32145970
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32124228
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31984577
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31053062
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29946880
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.29167685
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28137103
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27763012
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27468826
74TTF2_22483619_ChIP-Seq_HELA_Human1.26947210
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.26472454
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26336952
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25884033
78* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25423497
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25319739
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24926225
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23325965
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23097477
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.22216323
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21750975
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21632731
86AR_21909140_ChIP-Seq_LNCAP_Human1.21259268
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20940237
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20480239
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.20133459
90FOXP3_21729870_ChIP-Seq_TREG_Human1.19740120
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.18865246
92CLOCK_20551151_ChIP-Seq_293T_Human1.18152911
93ATF3_27146783_Chip-Seq_COLON_Human1.18025533
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17865607
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17752761
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16411675
97MAF_26560356_Chip-Seq_TH2_Human1.16330776
98* VDR_24763502_ChIP-Seq_THP-1_Human1.15776526
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15760527
100NCOR1_26117541_ChIP-Seq_K562_Human1.14916701
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14871771
102MYB_26560356_Chip-Seq_TH1_Human1.14358964
103GABP_19822575_ChIP-Seq_HepG2_Human1.13279163
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11832547
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11051562
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10723900
107* ELF1_20517297_ChIP-Seq_JURKAT_Human1.09725428
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.09431078
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.08783757
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08295707
111POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08285052
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08258361
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07431630
114TP53_22127205_ChIP-Seq_IMR90_Human1.05999741
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05699963
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05666179
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05116985
118TFEB_21752829_ChIP-Seq_HELA_Human1.04563895
119* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04502309
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03487225
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03465549
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03422659
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03400447
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03200253
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03060351
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.02881611
127VDR_23849224_ChIP-Seq_CD4+_Human1.02829092
128* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02754306
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02348649
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02078990
131* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01934337
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01729352
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01296635
134* BCOR_27268052_Chip-Seq_Bcells_Human1.01269485
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00287078
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99972378
137MYB_26560356_Chip-Seq_TH2_Human0.98642461
138SPI1_23127762_ChIP-Seq_K562_Human0.97921788
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97900838
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95098541
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94362546
142ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94350548
143SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94004047
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93736244
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92416176
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91992518
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91803727
148* LXR_22292898_ChIP-Seq_THP-1_Human0.91569389
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91114690
150* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90995725
151SPI1_23547873_ChIP-Seq_NB4_Human0.90729762
152CHD1_26751641_Chip-Seq_LNCaP_Human0.89926031
153MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89879240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.31593458
2MP0003693_abnormal_embryo_hatching3.24126014
3MP0008057_abnormal_DNA_replication3.23958120
4MP0005451_abnormal_body_composition3.18211995
5MP0010094_abnormal_chromosome_stability2.99717752
6MP0003077_abnormal_cell_cycle2.91378364
7MP0004957_abnormal_blastocyst_morpholog2.84227632
8MP0004858_abnormal_nervous_system2.59038942
9MP0010352_gastrointestinal_tract_polyps2.46891829
10MP0003436_decreased_susceptibility_to2.42938569
11MP0005076_abnormal_cell_differentiation2.42162360
12MP0009278_abnormal_bone_marrow2.26388807
13MP0002877_abnormal_melanocyte_morpholog2.24069538
14MP0004185_abnormal_adipocyte_glucose2.23679961
15MP0008260_abnormal_autophagy2.16809078
16MP0002396_abnormal_hematopoietic_system2.12775002
17MP0002653_abnormal_ependyma_morphology2.10619858
18MP0005058_abnormal_lysosome_morphology2.07226028
19MP0000350_abnormal_cell_proliferation2.05163106
20MP0008058_abnormal_DNA_repair1.96158876
21MP0010030_abnormal_orbit_morphology1.94691984
22MP0001730_embryonic_growth_arrest1.89806571
23MP0003121_genomic_imprinting1.83325368
24MP0002085_abnormal_embryonic_tissue1.82115137
25MP0003453_abnormal_keratinocyte_physiol1.81756320
26MP0001672_abnormal_embryogenesis/_devel1.77817689
27MP0005380_embryogenesis_phenotype1.77817689
28MP0002084_abnormal_developmental_patter1.76332308
29MP0008007_abnormal_cellular_replicative1.74185570
30MP0003123_paternal_imprinting1.74117913
31MP0008877_abnormal_DNA_methylation1.69303258
32MP0005409_darkened_coat_color1.69232836
33MP0004947_skin_inflammation1.68563081
34MP0000490_abnormal_crypts_of1.63240830
35MP0001697_abnormal_embryo_size1.62043390
36MP0006292_abnormal_olfactory_placode1.61923714
37MP0004197_abnormal_fetal_growth/weight/1.59886534
38MP0003984_embryonic_growth_retardation1.59878162
39MP0002796_impaired_skin_barrier1.59345050
40MP0008932_abnormal_embryonic_tissue1.59332153
41MP0002088_abnormal_embryonic_growth/wei1.57715386
42MP0004233_abnormal_muscle_weight1.57392234
43MP0003172_abnormal_lysosome_physiology1.55083618
44MP0010307_abnormal_tumor_latency1.54767633
45MP0002086_abnormal_extraembryonic_tissu1.54697205
46MP0004808_abnormal_hematopoietic_stem1.54127528
47MP0003091_abnormal_cell_migration1.52695059
48MP0003705_abnormal_hypodermis_morpholog1.48761620
49MP0000703_abnormal_thymus_morphology1.46395830
50MP0001545_abnormal_hematopoietic_system1.46072994
51MP0005397_hematopoietic_system_phenotyp1.46072994
52MP0001348_abnormal_lacrimal_gland1.44440227
53MP0010234_abnormal_vibrissa_follicle1.41985047
54MP0003119_abnormal_digestive_system1.39135845
55MP0003763_abnormal_thymus_physiology1.38458788
56MP0005666_abnormal_adipose_tissue1.36481103
57MP0002080_prenatal_lethality1.36341179
58MP0005501_abnormal_skin_physiology1.35341746
59MP0005623_abnormal_meninges_morphology1.33608893
60MP0009053_abnormal_anal_canal1.31685169
61MP0003890_abnormal_embryonic-extraembry1.31119946
62MP0002089_abnormal_postnatal_growth/wei1.30476737
63MP0000313_abnormal_cell_death1.29618522
64MP0002398_abnormal_bone_marrow1.29111724
65MP0001849_ear_inflammation1.27634432
66MP0005375_adipose_tissue_phenotype1.26645740
67MP0001293_anophthalmia1.25858087
68MP0000003_abnormal_adipose_tissue1.25592201
69MP0009840_abnormal_foam_cell1.23599813
70MP0002019_abnormal_tumor_incidence1.22903488
71MP0002249_abnormal_larynx_morphology1.21629482
72MP0000733_abnormal_muscle_development1.21503473
73MP0003566_abnormal_cell_adhesion1.16577448
74MP0004264_abnormal_extraembryonic_tissu1.13878945
75MP0003935_abnormal_craniofacial_develop1.13847204
76MP0000428_abnormal_craniofacial_morphol1.13039180
77MP0003787_abnormal_imprinting1.12597579
78MP0003786_premature_aging1.11258801
79MP0009333_abnormal_splenocyte_physiolog1.10979794
80MP0002722_abnormal_immune_system1.10583586
81MP0001873_stomach_inflammation1.07879169
82MP0003567_abnormal_fetal_cardiomyocyte1.05194332
83MP0003191_abnormal_cellular_cholesterol1.05082105
84MP0009931_abnormal_skin_appearance1.04104756
85MP0003303_peritoneal_inflammation1.03285189
86MP0003122_maternal_imprinting1.02982870
87MP0003937_abnormal_limbs/digits/tail_de1.02632685
88MP0002925_abnormal_cardiovascular_devel1.02166878
89MP0008995_early_reproductive_senescence1.02161169
90MP0005025_abnormal_response_to1.01713366
91MP0002932_abnormal_joint_morphology1.00999368
92MP0000049_abnormal_middle_ear1.00933767
93MP0002419_abnormal_innate_immunity0.99841341
94MP0000689_abnormal_spleen_morphology0.99128518
95MP0009703_decreased_birth_body0.98865858
96MP0005000_abnormal_immune_tolerance0.98714386
97MP0010630_abnormal_cardiac_muscle0.97577813
98MP0003315_abnormal_perineum_morphology0.96714180
99MP0009672_abnormal_birth_weight0.96685516
100MP0001915_intracranial_hemorrhage0.95677100
101MP0000432_abnormal_head_morphology0.93529579
102MP0003115_abnormal_respiratory_system0.93031146
103MP0000685_abnormal_immune_system0.92922170
104MP0000678_abnormal_parathyroid_gland0.92546400
105MP0003183_abnormal_peptide_metabolism0.92528226
106MP0008961_abnormal_basal_metabolism0.91473881
107MP0002420_abnormal_adaptive_immunity0.91087463
108MP0001800_abnormal_humoral_immune0.91028210
109MP0001819_abnormal_immune_cell0.90945535
110MP0000537_abnormal_urethra_morphology0.90289464
111MP0003329_amyloid_beta_deposits0.89460720
112MP0004381_abnormal_hair_follicle0.89400629
113MP0002111_abnormal_tail_morphology0.89151920
114MP0002092_abnormal_eye_morphology0.88329218
115MP0002210_abnormal_sex_determination0.88321979
116MP0002429_abnormal_blood_cell0.87216180
117MP0002405_respiratory_system_inflammati0.86974901
118MP0004510_myositis0.86531565
119MP0000716_abnormal_immune_system0.85126581
120MP0002723_abnormal_immune_serum0.84999264
121MP0004133_heterotaxia0.84055443
122MP0002116_abnormal_craniofacial_bone0.83580916
123MP0002697_abnormal_eye_size0.83563266
124MP0005387_immune_system_phenotype0.83166585
125MP0001790_abnormal_immune_system0.83166585
126MP0001835_abnormal_antigen_presentation0.82366578
127MP0001216_abnormal_epidermal_layer0.82102962
128MP0003861_abnormal_nervous_system0.81827515
129MP0005257_abnormal_intraocular_pressure0.81668574
130MP0003755_abnormal_palate_morphology0.81581702
131MP0001286_abnormal_eye_development0.81444357
132MP0001533_abnormal_skeleton_physiology0.80501314
133MP0002452_abnormal_antigen_presenting0.80481885
134MP0005023_abnormal_wound_healing0.80091028
135MP0000477_abnormal_intestine_morphology0.79129429
136MP0002998_abnormal_bone_remodeling0.78977052
137MP0000858_altered_metastatic_potential0.77407755
138MP0003300_gastrointestinal_ulcer0.77202286
139MP0008438_abnormal_cutaneous_collagen0.76863561
140MP0002009_preneoplasia0.76569145
141MP0005621_abnormal_cell_physiology0.76439940
142MP0008789_abnormal_olfactory_epithelium0.75953322
143MP0001145_abnormal_male_reproductive0.75427846
144MP0000566_synostosis0.75349001
145MP0003385_abnormal_body_wall0.74220673
146MP0002114_abnormal_axial_skeleton0.73695938
147MP0008770_decreased_survivor_rate0.71720976

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.64917691
2Obstructive sleep apnea (HP:0002870)3.22193516
3Rib fusion (HP:0000902)3.05659903
4Ependymoma (HP:0002888)2.98932045
5Chromsome breakage (HP:0040012)2.96470871
6Volvulus (HP:0002580)2.92037026
7Medulloblastoma (HP:0002885)2.91835925
8Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87739255
9Long eyelashes (HP:0000527)2.81971740
10Broad face (HP:0000283)2.81361398
11Short 4th metacarpal (HP:0010044)2.77192790
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.77192790
13Increased nuchal translucency (HP:0010880)2.66170049
14Patellar aplasia (HP:0006443)2.66062589
15Abnormal number of incisors (HP:0011064)2.64750878
16Ectopic kidney (HP:0000086)2.64579127
17Disproportionate tall stature (HP:0001519)2.59538082
18Hyperacusis (HP:0010780)2.56000477
19Aplasia/Hypoplasia of the patella (HP:0006498)2.53277950
20Neoplasm of the oral cavity (HP:0100649)2.53253961
21Selective tooth agenesis (HP:0001592)2.49153426
22Supernumerary ribs (HP:0005815)2.40340751
23Basal cell carcinoma (HP:0002671)2.40165187
24Eczematoid dermatitis (HP:0000976)2.38971914
25Proximal placement of thumb (HP:0009623)2.37915790
26Abnormality of the labia minora (HP:0012880)2.36646618
27Distal lower limb amyotrophy (HP:0008944)2.36483639
28Renal duplication (HP:0000075)2.35196475
29Abnormality of the astrocytes (HP:0100707)2.34909614
30Astrocytoma (HP:0009592)2.34909614
31Protrusio acetabuli (HP:0003179)2.31889115
32Deviation of the thumb (HP:0009603)2.31245132
33Flat acetabular roof (HP:0003180)2.30703960
34Trigonocephaly (HP:0000243)2.29802501
35Cellulitis (HP:0100658)2.27954828
36Reticulocytopenia (HP:0001896)2.27851627
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27166300
38Prominent nose (HP:0000448)2.24972379
39Achilles tendon contracture (HP:0001771)2.24387145
40Neoplasm of striated muscle (HP:0009728)2.24259739
41Supernumerary bones of the axial skeleton (HP:0009144)2.21271642
42Broad palm (HP:0001169)2.20300237
43Increased connective tissue (HP:0009025)2.20089598
44Shawl scrotum (HP:0000049)2.19434661
45Pseudobulbar signs (HP:0002200)2.16337442
46Cerebral aneurysm (HP:0004944)2.15264114
47Dysmetric saccades (HP:0000641)2.15196301
48Intestinal fistula (HP:0100819)2.14299158
49Sparse lateral eyebrow (HP:0005338)2.13613137
50Facial hemangioma (HP:0000329)2.13561331
51Distal upper limb amyotrophy (HP:0007149)2.12624304
52Upper limb amyotrophy (HP:0009129)2.12624304
53Abnormality of the thoracic spine (HP:0100711)2.12535862
54Deep palmar crease (HP:0006191)2.11720565
55Insomnia (HP:0100785)2.11714080
56Anal stenosis (HP:0002025)2.11330003
57Urethral obstruction (HP:0000796)2.10279037
58Metaphyseal cupping (HP:0003021)2.09391087
59Broad thumb (HP:0011304)2.08584744
60Rhabdomyosarcoma (HP:0002859)2.07187648
61Asymmetry of the thorax (HP:0001555)2.05619357
62Thin bony cortex (HP:0002753)2.03228945
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.02233531
64Abnormality of the 4th metacarpal (HP:0010012)2.02027865
65Broad distal phalanx of finger (HP:0009836)2.00606818
66Skin tags (HP:0010609)2.00484459
67Abnormality of the phalanges of the hallux (HP:0010057)1.99658004
68Segmental peripheral demyelination/remyelination (HP:0003481)1.99324577
69Large earlobe (HP:0009748)1.99097118
70Abnormality of the ileum (HP:0001549)1.98718232
71Bowel incontinence (HP:0002607)1.98346861
72Hemorrhage of the eye (HP:0011885)1.97996816
73Absent radius (HP:0003974)1.97559260
74Glioma (HP:0009733)1.96814179
75High anterior hairline (HP:0009890)1.96811983
76Biconcave vertebral bodies (HP:0004586)1.96651541
77Abnormality of the Achilles tendon (HP:0005109)1.96427844
78Colon cancer (HP:0003003)1.96201555
79Increased IgE level (HP:0003212)1.95028422
80Short 5th finger (HP:0009237)1.95001168
81Meckel diverticulum (HP:0002245)1.94393444
82Spina bifida occulta (HP:0003298)1.92653460
83Ulnar bowing (HP:0003031)1.92581240
84Breast hypoplasia (HP:0003187)1.92239504
85Abnormality of the intervertebral disk (HP:0005108)1.90001195
86Premature rupture of membranes (HP:0001788)1.88889491
87Patellar dislocation (HP:0002999)1.88489704
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.88049980
89Hypertensive crisis (HP:0100735)1.87908322
90Atresia of the external auditory canal (HP:0000413)1.87682478
91Myopathic facies (HP:0002058)1.87363507
92Vertebral compression fractures (HP:0002953)1.86900169
93Pointed chin (HP:0000307)1.86474787
94Reticulocytosis (HP:0001923)1.85288947
95Myelodysplasia (HP:0002863)1.84513595
96Abnormal large intestine physiology (HP:0012700)1.84477604
97Absent thumb (HP:0009777)1.84423303
98Abnormal gallbladder physiology (HP:0012438)1.83434638
99Cholecystitis (HP:0001082)1.83434638
100Acute lymphatic leukemia (HP:0006721)1.82954262
101Genu recurvatum (HP:0002816)1.82749494
102Heterotopia (HP:0002282)1.81980823
103Turricephaly (HP:0000262)1.81861079
104Short phalanx of the thumb (HP:0009660)1.81803673
105Preauricular skin tag (HP:0000384)1.81640281
106Polygenic inheritance (HP:0010982)1.81605361
107Hypercortisolism (HP:0001578)1.80975022
108Aplasia involving forearm bones (HP:0009822)1.80778067
109Absent forearm bone (HP:0003953)1.80778067
110Shallow orbits (HP:0000586)1.80092584
111Dislocated radial head (HP:0003083)1.79956248
112Malignant gastrointestinal tract tumors (HP:0006749)1.78859119
113Gastrointestinal carcinoma (HP:0002672)1.78859119
114Hemivertebrae (HP:0002937)1.77812394
115Cervical subluxation (HP:0003308)1.77530639
116Overlapping toe (HP:0001845)1.77215772
117Thin ribs (HP:0000883)1.77185302
118Vertebral fusion (HP:0002948)1.76898144
119Septate vagina (HP:0001153)1.76780454
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.76710821
121Lip pit (HP:0100267)1.76180610
122Abnormality of the columella (HP:0009929)1.75942252
123Hyperparathyroidism (HP:0000843)1.75535618
124High pitched voice (HP:0001620)1.75070182
125Abnormality of abdominal situs (HP:0011620)1.74829962
126Abdominal situs inversus (HP:0003363)1.74829962
127Depressed nasal tip (HP:0000437)1.74656035
128Broad phalanges of the hand (HP:0009768)1.74449694
129Abnormality of chromosome stability (HP:0003220)1.73266408
130Poikiloderma (HP:0001029)1.72539100
131Mitral regurgitation (HP:0001653)1.72116177
132Abnormality of DNA repair (HP:0003254)1.70876637
133Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70559289
134Slow saccadic eye movements (HP:0000514)1.70006743
135Short thumb (HP:0009778)1.69820743
136Abnormality of the carotid arteries (HP:0005344)1.69725191
137Thoracic kyphosis (HP:0002942)1.69390936
138Abnormality of the radial head (HP:0003995)1.69331079
139Spinal cord lesions (HP:0100561)1.69117868
140Syringomyelia (HP:0003396)1.69117868
141Gastrointestinal inflammation (HP:0004386)1.68890508
142Cafe-au-lait spot (HP:0000957)1.68637237
143Long palpebral fissure (HP:0000637)1.68473786
144Birth length less than 3rd percentile (HP:0003561)1.68256279
145Recurrent abscess formation (HP:0002722)1.67784474
146Blue sclerae (HP:0000592)1.67080974
147Duodenal stenosis (HP:0100867)1.67079140
148Small intestinal stenosis (HP:0012848)1.67079140
149Aplasia/hypoplasia of the humerus (HP:0006507)1.66738836
150Persistence of primary teeth (HP:0006335)1.65953812
151Easy fatigability (HP:0003388)1.65892696
152Truncus arteriosus (HP:0001660)1.65692840
153Cutis marmorata (HP:0000965)1.65584333
154Emphysema (HP:0002097)1.65121156
155Trismus (HP:0000211)1.65026877
156Premature skin wrinkling (HP:0100678)1.64269815
157Aneurysm (HP:0002617)1.64086849
158Chronic obstructive pulmonary disease (HP:0006510)1.63904280
159Obstructive lung disease (HP:0006536)1.63904280
160Abnormality of macrophages (HP:0004311)1.63798670
161Short humerus (HP:0005792)1.62707649
162Tracheoesophageal fistula (HP:0002575)1.62274187
163Colitis (HP:0002583)1.62255968
164Ankyloglossia (HP:0010296)1.62244456
165Sandal gap (HP:0001852)1.62199089
166Abnormality of the distal phalanges of the toes (HP:0010182)1.62166930
167Atelectasis (HP:0100750)1.61090640
168Fragile skin (HP:0001030)1.60658967
169Increased variability in muscle fiber diameter (HP:0003557)1.60248882
170Lower limb amyotrophy (HP:0007210)1.60136048
171Missing ribs (HP:0000921)1.60100703
172Abnormality of the preputium (HP:0100587)1.59179231
173Renovascular hypertension (HP:0100817)1.59016249
174Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58573367
175Skull defect (HP:0001362)1.57885114
176Progressive muscle weakness (HP:0003323)1.57533024
177Mitral valve prolapse (HP:0001634)1.56574214
178Arnold-Chiari malformation (HP:0002308)1.56571582
179Annular pancreas (HP:0001734)1.55878607
180Germ cell neoplasia (HP:0100728)1.55669047
181Advanced eruption of teeth (HP:0006288)1.55095347
182Recurrent bacterial skin infections (HP:0005406)1.54906977
183Neuronal loss in central nervous system (HP:0002529)1.53978731
184Cerebral inclusion bodies (HP:0100314)1.53625476
185Hand muscle atrophy (HP:0009130)1.52727439
186Gingivitis (HP:0000230)1.49634121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.01448594
2SMG13.75262281
3MAP3K103.42705205
4EEF2K3.16485293
5PRPF4B3.14704483
6CDC73.14383428
7ICK2.91606111
8BRD42.74480628
9NEK22.45835974
10IRAK32.21489896
11MAP4K12.10399679
12CDK72.06565869
13STK101.87475025
14MAP2K31.73078630
15CDK41.68956182
16TTK1.66824999
17ERN11.62348790
18RPS6KB21.61516511
19FGFR41.61097405
20RIPK41.51585758
21MAP3K131.48478138
22BUB11.48350921
23MTOR1.47714972
24LATS11.44863099
25PKN21.42147080
26NME21.38474641
27DYRK31.37446600
28SIK21.34467755
29TRIB31.34373549
30TAOK21.30180710
31KSR21.29858588
32ATR1.29567950
33CHEK11.23684064
34CHEK21.23110591
35RPS6KA41.22530669
36PLK11.22178596
37GRK61.21449060
38PASK1.21251509
39TESK21.20671846
40IRAK41.20070182
41ALK1.14394403
42TAOK31.12788792
43TAOK11.12488987
44MKNK21.11402077
45WEE11.10476827
46EPHB11.09971168
47PIM11.09866703
48PAK41.09307878
49SRPK11.09161303
50STK41.06962172
51CAMK1D1.06431172
52MKNK11.05314742
53MAP3K81.04660053
54BMX1.04508860
55MAP3K31.02891556
56MAP3K111.02858525
57IRAK21.00766503
58CDK21.00564924
59AURKB1.00420089
60CDK60.98611924
61MAP3K10.98301223
62TTN0.97137195
63EPHA20.96633970
64PRKD20.95998444
65LRRK20.95615028
66ATM0.95070655
67STK30.86082672
68MAP3K140.85871117
69TBK10.83256423
70CAMK1G0.83210838
71CDK90.82343892
72BTK0.80813019
73TLK10.80537199
74ARAF0.79548733
75PTK60.77299844
76PDPK10.76838506
77RPS6KA20.76158886
78MAP2K20.76108599
79LATS20.75925635
80CHUK0.75575995
81PRKD30.75381547
82DMPK0.74902400
83CSK0.68847724
84CDK10.68613411
85TGFBR10.66615500
86CLK10.65229961
87SIK10.64394538
88TYK20.63046176
89RIPK10.62499633
90TYRO30.62209641
91TNK20.62019701
92AKT20.61619105
93AURKA0.61312453
94JAK30.61304372
95MELK0.59459576
96MAP3K70.58980791
97TSSK60.58813568
98HIPK20.58094941
99* MAPK140.57656234
100TESK10.55954320
101PTK20.55019674
102RPS6KA10.54881160
103BRAF0.54800576
104MARK20.54705228
105CSF1R0.54702648
106EPHB20.54087353
107RPS6KA60.53731470
108BLK0.53614888
109ZAP700.53567152
110MAPK10.53114307
111MAPK110.52128204
112PDGFRA0.51876669
113CDK80.50648067
114PRKCI0.50261708
115MAP3K90.48548599
116PIM20.48410876
117AKT10.48090998
118PDK10.48055712
119RET0.47198744
120CDC42BPA0.46617885
121PAK10.46276208
122PLK40.45562152
123GSK3B0.44650813
124HCK0.44432839
125SCYL20.43328920
126PRKDC0.43262373
127CSNK1E0.43037258
128SIK30.42755581
129DYRK1B0.42693270
130SGK30.42573772
131MST1R0.42558472
132STK380.41181615
133MAP3K60.40706305
134MARK30.40491993
135RPS6KL10.40451257
136RPS6KC10.40451257
137UHMK10.40367823
138MAPKAPK20.40284790
139FLT30.40067006
140MOS0.36550963
141FGFR30.36084661
142PRKG20.33111098
143FGR0.32471693
144RAF10.31165386

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.15410340
2Spliceosome_Homo sapiens_hsa030402.88432750
3Mismatch repair_Homo sapiens_hsa034302.84725702
4Base excision repair_Homo sapiens_hsa034102.57609691
5Cell cycle_Homo sapiens_hsa041102.43772836
6RNA transport_Homo sapiens_hsa030132.38572389
7Homologous recombination_Homo sapiens_hsa034402.23921610
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23920219
9mRNA surveillance pathway_Homo sapiens_hsa030152.19174419
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12950261
11One carbon pool by folate_Homo sapiens_hsa006701.91626697
12Fanconi anemia pathway_Homo sapiens_hsa034601.86365675
13Notch signaling pathway_Homo sapiens_hsa043301.85431240
14Ribosome_Homo sapiens_hsa030101.83125869
15Nucleotide excision repair_Homo sapiens_hsa034201.79879885
16Other glycan degradation_Homo sapiens_hsa005111.66505579
17Chronic myeloid leukemia_Homo sapiens_hsa052201.58727192
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56684874
19Non-homologous end-joining_Homo sapiens_hsa034501.54821085
20Primary immunodeficiency_Homo sapiens_hsa053401.53056103
21Basal cell carcinoma_Homo sapiens_hsa052171.51923826
22MicroRNAs in cancer_Homo sapiens_hsa052061.48679043
23* RNA degradation_Homo sapiens_hsa030181.47151904
24Acute myeloid leukemia_Homo sapiens_hsa052211.44173235
25Lysine degradation_Homo sapiens_hsa003101.41804100
26p53 signaling pathway_Homo sapiens_hsa041151.37185561
27Herpes simplex infection_Homo sapiens_hsa051681.35985693
28HTLV-I infection_Homo sapiens_hsa051661.30506519
29RNA polymerase_Homo sapiens_hsa030201.29234515
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28837042
31Basal transcription factors_Homo sapiens_hsa030221.26383345
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24019286
33Prion diseases_Homo sapiens_hsa050201.23833523
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23463041
35Colorectal cancer_Homo sapiens_hsa052101.17344572
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16986769
37Hepatitis C_Homo sapiens_hsa051601.15607664
38B cell receptor signaling pathway_Homo sapiens_hsa046621.12402163
39Insulin signaling pathway_Homo sapiens_hsa049101.11609582
40Pentose phosphate pathway_Homo sapiens_hsa000301.11464329
41Small cell lung cancer_Homo sapiens_hsa052221.09938270
42mTOR signaling pathway_Homo sapiens_hsa041501.08694188
43Hedgehog signaling pathway_Homo sapiens_hsa043401.07646169
44Hippo signaling pathway_Homo sapiens_hsa043901.06948404
45Adherens junction_Homo sapiens_hsa045201.06145096
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06030596
47Fructose and mannose metabolism_Homo sapiens_hsa000511.05555911
48Non-small cell lung cancer_Homo sapiens_hsa052231.05397969
49Viral carcinogenesis_Homo sapiens_hsa052031.04104615
50Epstein-Barr virus infection_Homo sapiens_hsa051691.03986295
51Pancreatic cancer_Homo sapiens_hsa052121.03170406
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02189372
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.02150337
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01601640
55Thyroid cancer_Homo sapiens_hsa052160.99239503
56Endometrial cancer_Homo sapiens_hsa052130.96506240
57Choline metabolism in cancer_Homo sapiens_hsa052310.95717518
58Antigen processing and presentation_Homo sapiens_hsa046120.95135324
59Bladder cancer_Homo sapiens_hsa052190.94638998
60T cell receptor signaling pathway_Homo sapiens_hsa046600.93545135
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.92958186
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92664281
63Hepatitis B_Homo sapiens_hsa051610.92568154
64Estrogen signaling pathway_Homo sapiens_hsa049150.91544184
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91110586
66GnRH signaling pathway_Homo sapiens_hsa049120.90554658
67AMPK signaling pathway_Homo sapiens_hsa041520.89340569
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89200408
69Pyrimidine metabolism_Homo sapiens_hsa002400.88392099
70Pathways in cancer_Homo sapiens_hsa052000.87750030
71Prostate cancer_Homo sapiens_hsa052150.87455483
72Wnt signaling pathway_Homo sapiens_hsa043100.86467517
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84864443
74Apoptosis_Homo sapiens_hsa042100.84728218
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84707724
76Measles_Homo sapiens_hsa051620.84109457
77TGF-beta signaling pathway_Homo sapiens_hsa043500.83204398
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83200181
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83199724
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.82064705
81Proteoglycans in cancer_Homo sapiens_hsa052050.79866679
82Endocytosis_Homo sapiens_hsa041440.79069655
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.77998942
84Inositol phosphate metabolism_Homo sapiens_hsa005620.77957380
85Tuberculosis_Homo sapiens_hsa051520.77470743
86Oocyte meiosis_Homo sapiens_hsa041140.75943220
87Amoebiasis_Homo sapiens_hsa051460.75574505
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.75413520
89Sulfur relay system_Homo sapiens_hsa041220.75297070
90Insulin resistance_Homo sapiens_hsa049310.75033846
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74702485
92Shigellosis_Homo sapiens_hsa051310.74477806
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72092268
94Viral myocarditis_Homo sapiens_hsa054160.71900410
95Dorso-ventral axis formation_Homo sapiens_hsa043200.70853891
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.70383114
97Salmonella infection_Homo sapiens_hsa051320.69734217
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69096343
99VEGF signaling pathway_Homo sapiens_hsa043700.69058937
100Leishmaniasis_Homo sapiens_hsa051400.68777352
101Biosynthesis of amino acids_Homo sapiens_hsa012300.68713493
102Galactose metabolism_Homo sapiens_hsa000520.68483244
103Renal cell carcinoma_Homo sapiens_hsa052110.68298487
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.67777452
105Long-term potentiation_Homo sapiens_hsa047200.66794370
106Hematopoietic cell lineage_Homo sapiens_hsa046400.66674008
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.66050439
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66022397
109FoxO signaling pathway_Homo sapiens_hsa040680.64754104
110Influenza A_Homo sapiens_hsa051640.64402078
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.61826870
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61396818
113Prolactin signaling pathway_Homo sapiens_hsa049170.60353268
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59902320
115Toxoplasmosis_Homo sapiens_hsa051450.59530959
116Osteoclast differentiation_Homo sapiens_hsa043800.59190794
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.58307857
118Type II diabetes mellitus_Homo sapiens_hsa049300.57947083
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57582807
120Rap1 signaling pathway_Homo sapiens_hsa040150.55552339
121Malaria_Homo sapiens_hsa051440.54052374
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.53245128
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51958028
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51779454
125Glioma_Homo sapiens_hsa052140.50919029
126Melanoma_Homo sapiens_hsa052180.49527978
127ErbB signaling pathway_Homo sapiens_hsa040120.48139419
128HIF-1 signaling pathway_Homo sapiens_hsa040660.47842337
129Chemokine signaling pathway_Homo sapiens_hsa040620.46210881
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45163051
131TNF signaling pathway_Homo sapiens_hsa046680.45029185
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43979086
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43952303
134Focal adhesion_Homo sapiens_hsa045100.43156162
135MAPK signaling pathway_Homo sapiens_hsa040100.42354937
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41225910
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40693013
138Platelet activation_Homo sapiens_hsa046110.40655589

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