CNOT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.00278860
2polyketide metabolic process (GO:0030638)6.00278860
3doxorubicin metabolic process (GO:0044598)6.00278860
4interferon-gamma production (GO:0032609)4.10192009
5intra-S DNA damage checkpoint (GO:0031573)3.69262298
6piRNA metabolic process (GO:0034587)3.63842468
7neural tube formation (GO:0001841)3.62269002
8regulation of DNA endoreduplication (GO:0032875)3.51926992
9response to pheromone (GO:0019236)3.49420607
10retinal cone cell development (GO:0046549)3.47397283
11aminoglycoside antibiotic metabolic process (GO:0030647)3.45050991
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36405857
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.33532158
14regulation of translation, ncRNA-mediated (GO:0045974)3.33532158
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33532158
16regulation of cilium movement (GO:0003352)3.30517609
17replication fork processing (GO:0031297)3.23377616
18rRNA methylation (GO:0031167)3.20828517
19cilium morphogenesis (GO:0060271)3.19742238
20negative regulation of transcription regulatory region DNA binding (GO:2000678)3.17038466
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.16779631
22protein K11-linked deubiquitination (GO:0035871)3.16358038
23DNA double-strand break processing (GO:0000729)3.13995091
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12745697
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.12745697
26NADH dehydrogenase complex assembly (GO:0010257)3.12745697
27water-soluble vitamin biosynthetic process (GO:0042364)3.10551447
28protein complex biogenesis (GO:0070271)3.10061840
29regulation of nuclear cell cycle DNA replication (GO:0033262)3.07929461
30maintenance of protein location in nucleus (GO:0051457)3.07554246
31behavioral response to nicotine (GO:0035095)3.02538467
32DNA methylation involved in gamete generation (GO:0043046)3.02437737
33meiotic cell cycle (GO:0051321)2.96493726
34histone H3-K4 trimethylation (GO:0080182)2.95868846
35fucose catabolic process (GO:0019317)2.95621536
36L-fucose metabolic process (GO:0042354)2.95621536
37L-fucose catabolic process (GO:0042355)2.95621536
38intraciliary transport (GO:0042073)2.94081968
39phenol-containing compound catabolic process (GO:0019336)2.91868534
40positive regulation of meiosis (GO:0045836)2.89385380
41regulation of acrosome reaction (GO:0060046)2.89156623
42polyol catabolic process (GO:0046174)2.88978031
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87163436
44rRNA modification (GO:0000154)2.86945787
45mitochondrial respiratory chain complex assembly (GO:0033108)2.86417332
46histone H2A acetylation (GO:0043968)2.86077393
47microtubule severing (GO:0051013)2.86027446
48axoneme assembly (GO:0035082)2.85964809
49nonmotile primary cilium assembly (GO:0035058)2.85814596
50protein-cofactor linkage (GO:0018065)2.84614067
51telomere maintenance via telomerase (GO:0007004)2.83112210
52ventricular system development (GO:0021591)2.82153890
53anterograde synaptic vesicle transport (GO:0048490)2.81392791
54single strand break repair (GO:0000012)2.81324853
55respiratory chain complex IV assembly (GO:0008535)2.81191004
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80063168
57mitotic G2/M transition checkpoint (GO:0044818)2.79677753
58regulation of pigment cell differentiation (GO:0050932)2.79260288
59monoubiquitinated protein deubiquitination (GO:0035520)2.78871541
60negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.78644518
61detection of light stimulus involved in sensory perception (GO:0050962)2.78357876
62detection of light stimulus involved in visual perception (GO:0050908)2.78357876
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76418591
64RNA-dependent DNA replication (GO:0006278)2.75700263
65regulation of activation of Janus kinase activity (GO:0010533)2.74575202
66indolalkylamine metabolic process (GO:0006586)2.73836808
67positive regulation of meiotic cell cycle (GO:0051446)2.72963392
68somite rostral/caudal axis specification (GO:0032525)2.72460579
69cilium organization (GO:0044782)2.71157714
70regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70639411
71positive regulation of DNA-dependent DNA replication (GO:2000105)2.69287031
72regulation of telomere maintenance via telomerase (GO:0032210)2.68628882
73male meiosis I (GO:0007141)2.67855180
74cilium assembly (GO:0042384)2.67404460
75protein localization to cilium (GO:0061512)2.65868489
76photoreceptor cell development (GO:0042461)2.65372578
77pyrimidine nucleobase catabolic process (GO:0006208)2.64234767
78regulation of neurotransmitter uptake (GO:0051580)2.63924560
79reflex (GO:0060004)2.63281921
80protein targeting to Golgi (GO:0000042)2.63244267
81mitotic sister chromatid segregation (GO:0000070)2.62617676
82protein localization to Golgi apparatus (GO:0034067)2.62246988
83kinetochore organization (GO:0051383)2.60617165
84regulation of chronic inflammatory response (GO:0002676)2.59787912
85inositol phosphate catabolic process (GO:0071545)2.58911519
86kinetochore assembly (GO:0051382)2.58394634
87regulation of hexokinase activity (GO:1903299)2.57843844
88regulation of glucokinase activity (GO:0033131)2.57843844
89regulation of acyl-CoA biosynthetic process (GO:0050812)2.57342824
90regulation of MHC class I biosynthetic process (GO:0045343)2.57288240
91regulation of mitotic spindle checkpoint (GO:1903504)2.56731896
92limb bud formation (GO:0060174)2.55945161
93attachment of spindle microtubules to kinetochore (GO:0008608)2.55655554
94positive regulation of defense response to virus by host (GO:0002230)2.55001204
95protein K6-linked ubiquitination (GO:0085020)2.54854826
96DNA integration (GO:0015074)2.54853044
97cullin deneddylation (GO:0010388)2.53295101
98regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.53135227
99indole-containing compound catabolic process (GO:0042436)2.52439058
100indolalkylamine catabolic process (GO:0046218)2.52439058
101tryptophan catabolic process (GO:0006569)2.52439058
102presynaptic membrane organization (GO:0097090)2.50530088
103platelet dense granule organization (GO:0060155)2.48754526
104regulation of response to osmotic stress (GO:0047484)2.48557230
105peptidyl-lysine trimethylation (GO:0018023)2.48272039
106synapsis (GO:0007129)2.47056395
107centriole replication (GO:0007099)2.46709007
108negative regulation of systemic arterial blood pressure (GO:0003085)2.46677942
109negative regulation of telomere maintenance (GO:0032205)2.44796185
110cornea development in camera-type eye (GO:0061303)2.44774726
111regulation of mammary gland epithelial cell proliferation (GO:0033599)2.44304388
112recombinational repair (GO:0000725)2.44233644
113double-strand break repair via homologous recombination (GO:0000724)2.44150705
114negative regulation of cell cycle G2/M phase transition (GO:1902750)2.42235445
115regulation of meiosis I (GO:0060631)2.42001684
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41976965
117negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.41746230
118eye photoreceptor cell development (GO:0042462)2.41150885
119acrosome reaction (GO:0007340)2.40929872
120regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40501833
121protein neddylation (GO:0045116)2.37749995
122pyrimidine dimer repair (GO:0006290)2.37108434
123anterograde axon cargo transport (GO:0008089)2.35816991
124negative regulation of signal transduction by p53 class mediator (GO:1901797)2.35752542
125regulation of telomere maintenance (GO:0032204)2.35687198
126histone H4-K12 acetylation (GO:0043983)2.35276933
127protein polyglutamylation (GO:0018095)2.34501207
128photoreceptor cell maintenance (GO:0045494)2.34401823
129regulation of DNA-dependent DNA replication (GO:0090329)2.33613322
130rRNA transcription (GO:0009303)2.33451583
131sister chromatid cohesion (GO:0007062)2.33138541
132T cell differentiation involved in immune response (GO:0002292)2.31387158
133alpha-beta T cell differentiation involved in immune response (GO:0002293)2.31387158
134alpha-beta T cell activation involved in immune response (GO:0002287)2.31387158
135male meiosis (GO:0007140)2.29405700
136histone H3-K4 methylation (GO:0051568)2.28426074
137negative regulation of cell killing (GO:0031342)2.28118930
138negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.28118930
139protein deneddylation (GO:0000338)2.27802155
140reciprocal meiotic recombination (GO:0007131)2.24121430
141reciprocal DNA recombination (GO:0035825)2.24121430
142presynaptic membrane assembly (GO:0097105)2.23485659
143retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22250769
144DNA replication checkpoint (GO:0000076)2.22181549
145positive regulation of protein autophosphorylation (GO:0031954)2.21080397
146microtubule depolymerization (GO:0007019)2.19844290
147microtubule anchoring (GO:0034453)2.19559228
148proteasome assembly (GO:0043248)2.19464829
149regulation of chemokine-mediated signaling pathway (GO:0070099)2.19256877
150protein localization to microtubule cytoskeleton (GO:0072698)2.18947876
151regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.18851447
152positive regulation of developmental pigmentation (GO:0048087)2.16971959
153positive regulation of T cell cytokine production (GO:0002726)2.16788121
154establishment of protein localization to Golgi (GO:0072600)2.16517429
155sister chromatid segregation (GO:0000819)2.16095300
156meiotic chromosome segregation (GO:0045132)2.15876778
157positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.14171557
158centriole assembly (GO:0098534)2.12982672
159multicellular organism reproduction (GO:0032504)2.09242275
160positive regulation of histone H3-K4 methylation (GO:0051571)2.09152731
161neuron cell-cell adhesion (GO:0007158)2.08010076
162Rap protein signal transduction (GO:0032486)2.07289616
163T-helper cell differentiation (GO:0042093)2.05600389
164CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.05600389
165maturation of 5.8S rRNA (GO:0000460)2.04813126
166epithelial cilium movement (GO:0003351)2.02896567
167eosinophil chemotaxis (GO:0048245)2.02767554
168negative regulation by host of viral transcription (GO:0043922)2.01823937
169nuclear pore complex assembly (GO:0051292)2.01261153
170histone H4-K8 acetylation (GO:0043982)2.00430430
171histone H4-K5 acetylation (GO:0043981)2.00430430
172female gamete generation (GO:0007292)1.99939243
173regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)1.98803576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.96795648
2ZNF274_21170338_ChIP-Seq_K562_Hela3.21560735
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.05854882
4GBX2_23144817_ChIP-Seq_PC3_Human2.56456724
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51232074
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51232074
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51232074
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.46351651
9EZH2_22144423_ChIP-Seq_EOC_Human2.38739709
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34794157
11FUS_26573619_Chip-Seq_HEK293_Human2.34149545
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33513951
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.31305937
14IGF1R_20145208_ChIP-Seq_DFB_Human2.25452884
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21416776
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18907424
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15333308
18VDR_22108803_ChIP-Seq_LS180_Human2.08148827
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07027520
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06731887
21RNF2_27304074_Chip-Seq_NSC_Mouse2.02211304
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99207300
23TAF15_26573619_Chip-Seq_HEK293_Human1.98523314
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90679403
25* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87601497
26E2F7_22180533_ChIP-Seq_HELA_Human1.85770827
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.84466249
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81429449
29* IRF1_19129219_ChIP-ChIP_H3396_Human1.80945855
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75524675
31CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68560920
32EWS_26573619_Chip-Seq_HEK293_Human1.66452429
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58015610
34* P300_19829295_ChIP-Seq_ESCs_Human1.57786341
35* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57197081
36* CBP_20019798_ChIP-Seq_JUKART_Human1.57197081
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54393964
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53855618
39AR_25329375_ChIP-Seq_VCAP_Human1.53686009
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50824339
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49041168
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.48629840
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46831117
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.45927601
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45341632
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43337322
47BCAT_22108803_ChIP-Seq_LS180_Human1.41716714
48* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41680502
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41006808
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39311603
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.39157964
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37552416
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35876014
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35379480
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34631317
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34527640
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.33601052
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32117380
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.31326047
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29813485
61TP53_22573176_ChIP-Seq_HFKS_Human1.27890905
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27889995
63SMAD4_21799915_ChIP-Seq_A2780_Human1.27803531
64TCF4_22108803_ChIP-Seq_LS180_Human1.26804520
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.26796641
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.25248577
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.24870997
68P300_18555785_Chip-Seq_ESCs_Mouse1.24176400
69NMYC_18555785_Chip-Seq_ESCs_Mouse1.22456146
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21901060
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.21346878
72P53_22387025_ChIP-Seq_ESCs_Mouse1.21144709
73* NANOG_19829295_ChIP-Seq_ESCs_Human1.20509922
74* SOX2_19829295_ChIP-Seq_ESCs_Human1.20509922
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.20471282
76VDR_23849224_ChIP-Seq_CD4+_Human1.20231629
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19316299
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18823253
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18025205
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.17710502
81MYC_18940864_ChIP-ChIP_HL60_Human1.17683447
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17571326
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17571326
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.17495716
85* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16601936
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16316291
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15084584
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14443027
89* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12348366
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12177581
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12168147
92* EST1_17652178_ChIP-ChIP_JURKAT_Human1.12043930
93* TAL1_26923725_Chip-Seq_HPCs_Mouse1.10620740
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.10449137
95* SMAD4_21741376_ChIP-Seq_EPCs_Human1.10372932
96KLF4_18555785_Chip-Seq_ESCs_Mouse1.09414086
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08413557
98* STAT3_23295773_ChIP-Seq_U87_Human1.08254327
99ELK1_19687146_ChIP-ChIP_HELA_Human1.08192935
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07672578
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07637482
102* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06503338
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06231253
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06124939
105CTCF_18555785_Chip-Seq_ESCs_Mouse1.05966564
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.05263920
107SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04767836
108* CDX2_22108803_ChIP-Seq_LS180_Human1.04233071
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03514608
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03025745
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.02715438
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01452162
113ER_23166858_ChIP-Seq_MCF-7_Human1.01254374
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.01085654
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00378651
116ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99959281
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.99921022
118TCF4_23295773_ChIP-Seq_U87_Human0.99121599
119* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98446536
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97602799
121RUNX2_22187159_ChIP-Seq_PCA_Human0.97476095
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.97434932
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97401569
124* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97215249
125TP53_16413492_ChIP-PET_HCT116_Human0.97189672
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96215858
127* REST_21632747_ChIP-Seq_MESCs_Mouse0.95963286
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93591945
129JUN_21703547_ChIP-Seq_K562_Human0.93414106
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92462270
131PU1_27457419_Chip-Seq_LIVER_Mouse0.91306736
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90843692
133* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90512069
134* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90275619
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89848150
136IRF8_21731497_ChIP-ChIP_J774_Mouse0.87860640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.94174997
2MP0008057_abnormal_DNA_replication3.66048541
3MP0003787_abnormal_imprinting3.26473475
4MP0008877_abnormal_DNA_methylation3.06824688
5MP0003880_abnormal_central_pattern2.82200394
6MP0000372_irregular_coat_pigmentation2.75960061
7MP0008058_abnormal_DNA_repair2.25725280
8MP0003121_genomic_imprinting2.23943858
9MP0003646_muscle_fatigue2.21763200
10MP0002396_abnormal_hematopoietic_system2.19519422
11MP0005551_abnormal_eye_electrophysiolog1.98133747
12MP0005671_abnormal_response_to1.97321036
13MP0002638_abnormal_pupillary_reflex1.91728464
14MP0000427_abnormal_hair_cycle1.86248613
15MP0001188_hyperpigmentation1.77205211
16MP0005075_abnormal_melanosome_morpholog1.76197524
17MP0006072_abnormal_retinal_apoptosis1.72506744
18MP0002837_dystrophic_cardiac_calcinosis1.71171558
19MP0005394_taste/olfaction_phenotype1.67826078
20MP0005499_abnormal_olfactory_system1.67826078
21MP0002277_abnormal_respiratory_mucosa1.67801598
22MP0010094_abnormal_chromosome_stability1.65302326
23MP0003195_calcinosis1.64346666
24MP0000015_abnormal_ear_pigmentation1.64250450
25MP0003890_abnormal_embryonic-extraembry1.63977435
26MP0000569_abnormal_digit_pigmentation1.62164153
27MP0002095_abnormal_skin_pigmentation1.57119984
28MP0000383_abnormal_hair_follicle1.52818418
29MP0001905_abnormal_dopamine_level1.52204039
30MP0001529_abnormal_vocalization1.50759776
31MP0004133_heterotaxia1.49111952
32MP0003122_maternal_imprinting1.47091197
33MP0008995_early_reproductive_senescence1.46764312
34MP0005645_abnormal_hypothalamus_physiol1.43436002
35MP0003136_yellow_coat_color1.42361608
36MP0004957_abnormal_blastocyst_morpholog1.40030201
37MP0001501_abnormal_sleep_pattern1.37607798
38MP0000647_abnormal_sebaceous_gland1.36386613
39MP0005410_abnormal_fertilization1.33573484
40MP0002332_abnormal_exercise_endurance1.32376052
41MP0003718_maternal_effect1.31410934
42MP0003183_abnormal_peptide_metabolism1.30609632
43MP0004215_abnormal_myocardial_fiber1.29919370
44MP0003011_delayed_dark_adaptation1.29680734
45MP0002928_abnormal_bile_duct1.27306099
46MP0002102_abnormal_ear_morphology1.26926192
47MP0004381_abnormal_hair_follicle1.25443947
48MP0009046_muscle_twitch1.24551986
49MP0008961_abnormal_basal_metabolism1.22282383
50MP0009697_abnormal_copulation1.20528015
51MP0005174_abnormal_tail_pigmentation1.18987264
52MP0005187_abnormal_penis_morphology1.18081972
53MP0005310_abnormal_salivary_gland1.17325434
54MP0004043_abnormal_pH_regulation1.15102003
55MP0002572_abnormal_emotion/affect_behav1.14922854
56MP0004924_abnormal_behavior1.12511789
57MP0005386_behavior/neurological_phenoty1.12511789
58MP0004264_abnormal_extraembryonic_tissu1.12250626
59MP0002876_abnormal_thyroid_physiology1.11822446
60MP0003938_abnormal_ear_development1.10507622
61MP0003077_abnormal_cell_cycle1.10498648
62MP0001293_anophthalmia1.09403827
63MP0006082_CNS_inflammation1.08372713
64MP0001486_abnormal_startle_reflex1.07349296
65MP0002557_abnormal_social/conspecific_i1.07187836
66MP0004270_analgesia1.07104655
67MP0000049_abnormal_middle_ear1.05572862
68MP0001929_abnormal_gametogenesis1.04856601
69MP0002009_preneoplasia1.03274235
70MP0001986_abnormal_taste_sensitivity1.02932662
71MP0005409_darkened_coat_color1.01784498
72MP0008872_abnormal_physiological_respon1.00360053
73MP0003315_abnormal_perineum_morphology0.98967734
74MP0001968_abnormal_touch/_nociception0.98629182
75MP0001790_abnormal_immune_system0.97941762
76MP0005387_immune_system_phenotype0.97941762
77MP0002148_abnormal_hypersensitivity_rea0.97704809
78MP0002736_abnormal_nociception_after0.97276748
79MP0001835_abnormal_antigen_presentation0.97078183
80MP0004142_abnormal_muscle_tone0.96948404
81MP0006276_abnormal_autonomic_nervous0.95111941
82MP0000778_abnormal_nervous_system0.94976569
83MP0010678_abnormal_skin_adnexa0.94599568
84MP0009250_abnormal_appendicular_skeleto0.93445493
85MP0003698_abnormal_male_reproductive0.93245724
86MP0004134_abnormal_chest_morphology0.93136372
87MP0002160_abnormal_reproductive_system0.92829586
88MP0001502_abnormal_circadian_rhythm0.92155377
89MP0005000_abnormal_immune_tolerance0.91713802
90MP0001324_abnormal_eye_pigmentation0.91283093
91MP0005171_absent_coat_pigmentation0.90920311
92MP0006035_abnormal_mitochondrial_morpho0.90786630
93MP0003950_abnormal_plasma_membrane0.89287735
94MP0001485_abnormal_pinna_reflex0.88695964
95MP0002210_abnormal_sex_determination0.88096669
96MP0000678_abnormal_parathyroid_gland0.87819332
97MP0005257_abnormal_intraocular_pressure0.87534919
98MP0008932_abnormal_embryonic_tissue0.87386970
99MP0005423_abnormal_somatic_nervous0.87254837
100MP0000653_abnormal_sex_gland0.86571733
101MP0002234_abnormal_pharynx_morphology0.86088021
102MP0008789_abnormal_olfactory_epithelium0.85949635
103MP0001800_abnormal_humoral_immune0.85720143
104MP0008875_abnormal_xenobiotic_pharmacok0.85532475
105MP0002127_abnormal_cardiovascular_syste0.84688216
106MP0002163_abnormal_gland_morphology0.84211015
107MP0009745_abnormal_behavioral_response0.83558707
108MP0005389_reproductive_system_phenotype0.83138390
109MP0002233_abnormal_nose_morphology0.82743433
110MP0003567_abnormal_fetal_cardiomyocyte0.82714703
111MP0005253_abnormal_eye_physiology0.82449703
112MP0003755_abnormal_palate_morphology0.82444424
113MP0003635_abnormal_synaptic_transmissio0.81144882
114MP0003763_abnormal_thymus_physiology0.81015418
115MP0002723_abnormal_immune_serum0.80805954
116MP0004085_abnormal_heartbeat0.80048881
117MP0002229_neurodegeneration0.79655382
118MP0003786_premature_aging0.79653753
119MP0005646_abnormal_pituitary_gland0.79574649
120MP0004484_altered_response_of0.79389844
121MP0002420_abnormal_adaptive_immunity0.79280377
122MP0005195_abnormal_posterior_eye0.79124611
123MP0005084_abnormal_gallbladder_morpholo0.79004029
124MP0002734_abnormal_mechanical_nocicepti0.78319775
125MP0001819_abnormal_immune_cell0.78176255
126MP0002735_abnormal_chemical_nociception0.77766703
127MP0002398_abnormal_bone_marrow0.77044806
128MP0002272_abnormal_nervous_system0.76700053
129MP0001984_abnormal_olfaction0.75740686
130MP0001963_abnormal_hearing_physiology0.74815199
131MP0000631_abnormal_neuroendocrine_gland0.74510682
132MP0002653_abnormal_ependyma_morphology0.74095478
133MP0003937_abnormal_limbs/digits/tail_de0.73794201
134MP0001145_abnormal_male_reproductive0.73551679
135MP0004145_abnormal_muscle_electrophysio0.73189403
136MP0008007_abnormal_cellular_replicative0.72656480
137MP0002938_white_spotting0.72038521
138MP0002452_abnormal_antigen_presenting0.71921863
139MP0002067_abnormal_sensory_capabilities0.71758809
140MP0002751_abnormal_autonomic_nervous0.70957410
141MP0000703_abnormal_thymus_morphology0.70406975
142MP0002177_abnormal_outer_ear0.70389007
143MP0002064_seizures0.69338256
144MP0000432_abnormal_head_morphology0.69069045
145MP0005379_endocrine/exocrine_gland_phen0.68103446
146MP0002063_abnormal_learning/memory/cond0.67850669
147MP0002114_abnormal_axial_skeleton0.67720158
148MP0002752_abnormal_somatic_nervous0.67260382

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.10316616
2Pancreatic fibrosis (HP:0100732)4.00648734
3Chromsome breakage (HP:0040012)3.91947807
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78766171
5True hermaphroditism (HP:0010459)3.55294676
6Nephroblastoma (Wilms tumor) (HP:0002667)3.36561243
7Bilateral microphthalmos (HP:0007633)3.24246076
8Abnormality of the renal medulla (HP:0100957)3.19247630
9Chronic hepatic failure (HP:0100626)3.19199209
10Embryonal renal neoplasm (HP:0011794)3.16905641
11Hyperventilation (HP:0002883)2.99361430
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94047534
13Acute necrotizing encephalopathy (HP:0006965)2.86887925
14Abnormal hair whorl (HP:0010721)2.84938937
15Febrile seizures (HP:0002373)2.80240312
16Gait imbalance (HP:0002141)2.77242385
17Intestinal atresia (HP:0011100)2.75405175
18Hypochromic microcytic anemia (HP:0004840)2.75123937
193-Methylglutaconic aciduria (HP:0003535)2.73375858
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.70847530
21Volvulus (HP:0002580)2.70025909
22Progressive macrocephaly (HP:0004481)2.69572580
23Abnormality of the renal cortex (HP:0011035)2.68484207
24Congenital primary aphakia (HP:0007707)2.67210611
25Acute encephalopathy (HP:0006846)2.61858548
26Optic neuritis (HP:0100653)2.61819968
27Retrobulbar optic neuritis (HP:0100654)2.61819968
28Hypoplasia of the fovea (HP:0007750)2.60615624
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.60615624
30Oligodactyly (hands) (HP:0001180)2.58036832
31Broad-based gait (HP:0002136)2.54082168
32Nephrogenic diabetes insipidus (HP:0009806)2.53841211
33Nasolacrimal duct obstruction (HP:0000579)2.51856071
34Orchitis (HP:0100796)2.46361750
35Rib fusion (HP:0000902)2.45665764
36Abnormal mitochondria in muscle tissue (HP:0008316)2.44876169
37Drooling (HP:0002307)2.41523636
38Supernumerary spleens (HP:0009799)2.40224686
39Rectovaginal fistula (HP:0000143)2.39630159
40Rectal fistula (HP:0100590)2.39630159
41Anomalous pulmonary venous return (HP:0010772)2.38556878
42Intestinal fistula (HP:0100819)2.38247402
43Abnormal ciliary motility (HP:0012262)2.36133584
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.36060683
45Absent/shortened dynein arms (HP:0200106)2.36060683
46Fair hair (HP:0002286)2.35471961
47Genital tract atresia (HP:0001827)2.33136450
48Neoplasm of the adrenal cortex (HP:0100641)2.33059767
49Cystic liver disease (HP:0006706)2.29166688
50Type II lissencephaly (HP:0007260)2.28684393
51Tubular atrophy (HP:0000092)2.27550591
52Progressive cerebellar ataxia (HP:0002073)2.27323087
53Anencephaly (HP:0002323)2.26399014
54Mitochondrial inheritance (HP:0001427)2.24157784
55Absent frontal sinuses (HP:0002688)2.22272703
56Increased CSF lactate (HP:0002490)2.21753077
57Abnormality of midbrain morphology (HP:0002418)2.20545723
58Molar tooth sign on MRI (HP:0002419)2.20545723
59Abnormality of the fovea (HP:0000493)2.19599757
60Colon cancer (HP:0003003)2.19085540
61Vaginal atresia (HP:0000148)2.18930386
62Congenital stationary night blindness (HP:0007642)2.17676404
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.16117267
64Abnormal respiratory motile cilium physiology (HP:0012261)2.15248586
65Bile duct proliferation (HP:0001408)2.14783481
66Abnormal biliary tract physiology (HP:0012439)2.14783481
67Abnormal lung lobation (HP:0002101)2.14340834
68Excessive salivation (HP:0003781)2.12937032
69Prostate neoplasm (HP:0100787)2.11851778
70Abolished electroretinogram (ERG) (HP:0000550)2.11844041
71Sclerocornea (HP:0000647)2.11561268
72Lissencephaly (HP:0001339)2.11390090
73Pendular nystagmus (HP:0012043)2.10745274
74Gaze-evoked nystagmus (HP:0000640)2.07692083
75Calf muscle hypertrophy (HP:0008981)2.06616504
76Abnormality of chromosome segregation (HP:0002916)2.05799466
77Attenuation of retinal blood vessels (HP:0007843)2.04921752
78Abnormality of the preputium (HP:0100587)2.04786199
79Protruding tongue (HP:0010808)2.04720484
80Epileptic encephalopathy (HP:0200134)2.04456054
81Genetic anticipation (HP:0003743)2.04185359
82Hypothermia (HP:0002045)2.03552477
83Meckel diverticulum (HP:0002245)2.03417068
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02654296
85Sensory axonal neuropathy (HP:0003390)2.00584227
86Poor coordination (HP:0002370)2.00320382
87Congenital hepatic fibrosis (HP:0002612)1.98885964
88Abnormality of the pulmonary veins (HP:0011718)1.98252605
89Abnormality of chromosome stability (HP:0003220)1.96951539
90Abnormality of the labia minora (HP:0012880)1.96885094
91Impulsivity (HP:0100710)1.96878547
92Partial duplication of thumb phalanx (HP:0009944)1.96037190
93Abnormality of the lacrimal duct (HP:0011481)1.95786784
94Short tibia (HP:0005736)1.95600593
95Methylmalonic acidemia (HP:0002912)1.95301196
96Flat capital femoral epiphysis (HP:0003370)1.94881074
97Papillary thyroid carcinoma (HP:0002895)1.94874798
98Male pseudohermaphroditism (HP:0000037)1.94261971
99Metaphyseal dysplasia (HP:0100255)1.94233370
100Abnormality of the ileum (HP:0001549)1.92915757
101Abnormal respiratory motile cilium morphology (HP:0005938)1.92031824
102Abnormal respiratory epithelium morphology (HP:0012253)1.92031824
103Postaxial foot polydactyly (HP:0001830)1.91266405
104Renal cortical cysts (HP:0000803)1.90535778
105Aplasia/hypoplasia of the uterus (HP:0008684)1.90435768
106Abnormality of the frontal sinuses (HP:0002687)1.89546850
107Inability to walk (HP:0002540)1.88843534
108Preaxial hand polydactyly (HP:0001177)1.88469028
109Widely spaced teeth (HP:0000687)1.88247111
110Medial flaring of the eyebrow (HP:0010747)1.87945222
111Dyschromatopsia (HP:0007641)1.87925317
112Abnormality of the phalanges of the hallux (HP:0010057)1.86748450
113Cerebellar dysplasia (HP:0007033)1.85913394
114Duplication of thumb phalanx (HP:0009942)1.85473322
115Horizontal nystagmus (HP:0000666)1.85273231
116Occipital encephalocele (HP:0002085)1.84725287
117Cleft eyelid (HP:0000625)1.84536811
118Limb dystonia (HP:0002451)1.83946997
119Thyroid-stimulating hormone excess (HP:0002925)1.83945078
120Optic nerve hypoplasia (HP:0000609)1.83165936
121Hypoplastic iliac wings (HP:0002866)1.82327340
122Progressive inability to walk (HP:0002505)1.81609216
123Postaxial hand polydactyly (HP:0001162)1.81165840
124Generalized hypopigmentation of hair (HP:0011358)1.81063806
125Muscle hypertrophy of the lower extremities (HP:0008968)1.81033399
126Aplasia cutis congenita (HP:0001057)1.80444510
127Microvesicular hepatic steatosis (HP:0001414)1.80053128
128Abnormal rod and cone electroretinograms (HP:0008323)1.79757020
129Disproportionate short-trunk short stature (HP:0003521)1.78410011
130Abnormality of the nasolacrimal system (HP:0000614)1.78038435
131Hepatoblastoma (HP:0002884)1.77212050
132Atonic seizures (HP:0010819)1.76795508
133Narrow forehead (HP:0000341)1.76520882
134Hemiparesis (HP:0001269)1.76296674
135Abnormality of the incisor (HP:0000676)1.75936788
136Amyotrophic lateral sclerosis (HP:0007354)1.74982013
137Decreased central vision (HP:0007663)1.74895788
138Optic disc pallor (HP:0000543)1.74802428
139Tubulointerstitial nephritis (HP:0001970)1.74331532
140Renal Fanconi syndrome (HP:0001994)1.73053858
141Gastrointestinal atresia (HP:0002589)1.72019801
142Myositis (HP:0100614)1.71662956
143Abnormality of incisor morphology (HP:0011063)1.71456750
144Specific learning disability (HP:0001328)1.71201896
145Dandy-Walker malformation (HP:0001305)1.70622049
146Triphalangeal thumb (HP:0001199)1.70435329
147Myelodysplasia (HP:0002863)1.70318998
148Combined immunodeficiency (HP:0005387)1.69793972
149Furrowed tongue (HP:0000221)1.69768198
150Bifid tongue (HP:0010297)1.69278823
151Periauricular skin pits (HP:0100277)1.68827377
152Preauricular pit (HP:0004467)1.68827377
153Osteomalacia (HP:0002749)1.68546071
154Ectopic kidney (HP:0000086)1.68186954
155Oculomotor apraxia (HP:0000657)1.67392740
156Rhinitis (HP:0012384)1.66944284
157Astigmatism (HP:0000483)1.66526186
158Sloping forehead (HP:0000340)1.66465131
159Bony spicule pigmentary retinopathy (HP:0007737)1.66048471
160Abnormality of the columella (HP:0009929)1.65573453
161Growth hormone deficiency (HP:0000824)1.65478932
162Agnosia (HP:0010524)1.64391569
163Pachygyria (HP:0001302)1.62671342
164Keratoconjunctivitis sicca (HP:0001097)1.62107494
165Vaginal fistula (HP:0004320)1.61884142
166Polydipsia (HP:0001959)1.61603215
167Abnormal drinking behavior (HP:0030082)1.61603215
168Supernumerary bones of the axial skeleton (HP:0009144)1.61421394
169Duodenal stenosis (HP:0100867)1.61379845
170Small intestinal stenosis (HP:0012848)1.61379845
171Short middle phalanx of the 5th finger (HP:0004220)1.60824146
172Embryonal neoplasm (HP:0002898)1.60648066
173Facial cleft (HP:0002006)1.60553745
174Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59156306
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.57827426
176Partial duplication of the phalanx of hand (HP:0009999)1.57219393
177Nephronophthisis (HP:0000090)1.55642708
178Small hand (HP:0200055)1.54735600
179Absent speech (HP:0001344)1.54421779
180Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.53394864
181Focal motor seizures (HP:0011153)1.52685933
182Supernumerary ribs (HP:0005815)1.52552966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.64233705
2FRK4.26929733
3GRK53.10100546
4CASK2.80593751
5MAP4K22.79530750
6GRK72.57360134
7ADRBK22.54359527
8WNK32.53811940
9TRIM282.34949372
10MAP2K72.15979675
11GRK62.04013073
12BMPR1B1.96423530
13TGFBR21.92964534
14RIPK41.88311511
15BRSK21.87497664
16BMPR21.86510150
17GRK11.79559437
18NUAK11.71355233
19TAOK31.68653345
20TTK1.66893788
21MARK11.62346619
22MAP3K121.59210884
23EIF2AK31.57981076
24SIK31.57534029
25MAP3K131.51667045
26CDK81.51152261
27MST41.50879711
28PINK11.50378353
29MKNK21.50109748
30MAP3K141.48166853
31PAK31.39773807
32ERBB31.35393251
33MUSK1.34943580
34OBSCN1.32697021
35PNCK1.31664346
36TNIK1.31003054
37STK161.29686415
38MAP3K41.29417934
39TXK1.25933119
40WNK11.24892737
41CHEK21.22704388
42NLK1.21798596
43STK38L1.21618632
44EIF2AK21.20932478
45CSF1R1.19618973
46PLK41.18315570
47BLK1.17478308
48EIF2AK11.17101790
49CDK31.16075269
50PLK21.14062732
51CSNK1G11.11969043
52VRK11.11149962
53PHKG21.08092293
54PHKG11.08092293
55WEE11.07643935
56PBK1.06515999
57MKNK11.06446810
58MAPK131.05866820
59MAPK71.05255290
60CDC70.99881728
61STK100.99524580
62CDK70.99428749
63SRPK10.97869350
64EPHA40.94107081
65YES10.93838292
66MOS0.92890598
67WNK40.92775572
68AKT30.90390536
69MAP3K60.89885076
70NTRK30.87663612
71SGK20.87432969
72PRKCE0.85591843
73CSNK1A1L0.84168226
74IKBKB0.84088901
75INSRR0.82112332
76FGFR20.80217069
77STK30.79269438
78MATK0.79089028
79ADRBK10.78727475
80BCR0.78424989
81CAMK40.78053767
82CSNK1G20.76489071
83BRD40.75900266
84STK390.75560225
85CHUK0.75225964
86PRKCG0.74567548
87MAP2K40.72575798
88CDK90.71982731
89NEK60.71399084
90PLK10.68299963
91ATM0.68125653
92MARK20.67940378
93CSNK1G30.67835360
94DYRK30.67042541
95PRPF4B0.63743768
96ZAK0.63341836
97TLK10.63032851
98FER0.63020979
99CHEK10.62661589
100MAPKAPK50.62617997
101ACVR1B0.62153795
102TYRO30.60614852
103CCNB10.60111840
104DYRK1A0.57275714
105NME10.55564536
106PRKCQ0.53842895
107MARK30.53298317
108OXSR10.52540006
109CAMK10.52415244
110FGR0.52205699
111PTK2B0.51510129
112PIK3CA0.50276823
113PRKAA10.49871977
114MINK10.49368219
115CAMK1G0.49340568
116TEC0.48125741
117TGFBR10.47873876
118CSNK1D0.47308858
119CAMK2A0.46394658
120BRSK10.45697083
121PRKCI0.45597660
122TAF10.44898238
123PRKG10.44823430
124SGK2230.44809305
125SGK4940.44809305
126NEK10.43329411
127PLK30.42824144
128PKN10.42053333
129JAK30.41799044
130PIK3CG0.41697124
131FES0.41539834
132STK110.41192431
133PRKACA0.40122225
134LCK0.39169168
135DYRK20.38873416
136HIPK20.38794603
137ATR0.38070673
138CLK10.37928875
139CSNK1E0.37392999
140CAMKK20.37299017
141NTRK20.37255553
142SIK20.37207703
143STK40.35801120
144BUB10.35115643
145IRAK40.34393468
146MAPK100.33624490
147CAMK1D0.32195842
148* CDK10.32087270
149MAPK120.29525858
150CSK0.29401370

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.11840707
2Homologous recombination_Homo sapiens_hsa034402.36029642
3Circadian rhythm_Homo sapiens_hsa047102.30873510
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29090289
5Butanoate metabolism_Homo sapiens_hsa006502.26977941
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15778912
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15317935
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96422128
9Fanconi anemia pathway_Homo sapiens_hsa034601.95909609
10Propanoate metabolism_Homo sapiens_hsa006401.94725627
11RNA polymerase_Homo sapiens_hsa030201.92771189
12Basal transcription factors_Homo sapiens_hsa030221.87488178
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73347248
14Regulation of autophagy_Homo sapiens_hsa041401.70349036
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64123543
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57129123
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54591839
18Graft-versus-host disease_Homo sapiens_hsa053321.53037587
19Nicotine addiction_Homo sapiens_hsa050331.52490546
20* RNA degradation_Homo sapiens_hsa030181.51909918
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.51695359
22Oxidative phosphorylation_Homo sapiens_hsa001901.37020598
23Nitrogen metabolism_Homo sapiens_hsa009101.34398599
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32970685
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30325306
26Caffeine metabolism_Homo sapiens_hsa002321.27123727
27Rheumatoid arthritis_Homo sapiens_hsa053231.24490909
28Serotonergic synapse_Homo sapiens_hsa047261.22524033
29Allograft rejection_Homo sapiens_hsa053301.21783078
30Ether lipid metabolism_Homo sapiens_hsa005651.18438311
31Arachidonic acid metabolism_Homo sapiens_hsa005901.18194349
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14680067
33Peroxisome_Homo sapiens_hsa041461.14518248
34Cell cycle_Homo sapiens_hsa041101.13981391
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12338070
36Cardiac muscle contraction_Homo sapiens_hsa042601.11263993
37Olfactory transduction_Homo sapiens_hsa047401.11115265
38Vitamin B6 metabolism_Homo sapiens_hsa007501.09689533
39Selenocompound metabolism_Homo sapiens_hsa004501.08031736
40Huntingtons disease_Homo sapiens_hsa050161.05362513
41Tryptophan metabolism_Homo sapiens_hsa003801.04129543
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.03053784
43Taste transduction_Homo sapiens_hsa047421.02690309
44Phototransduction_Homo sapiens_hsa047441.02445399
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.01741474
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.01456347
47Linoleic acid metabolism_Homo sapiens_hsa005911.00936235
48Mismatch repair_Homo sapiens_hsa034301.00631555
49Glutamatergic synapse_Homo sapiens_hsa047241.00245862
50Asthma_Homo sapiens_hsa053100.98642695
51RNA transport_Homo sapiens_hsa030130.98224306
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95331952
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93386590
54Dorso-ventral axis formation_Homo sapiens_hsa043200.92564876
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92495986
56Alzheimers disease_Homo sapiens_hsa050100.91966326
57Collecting duct acid secretion_Homo sapiens_hsa049660.91703379
58mRNA surveillance pathway_Homo sapiens_hsa030150.91399895
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91283341
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91277525
61Hematopoietic cell lineage_Homo sapiens_hsa046400.91184740
62African trypanosomiasis_Homo sapiens_hsa051430.90788489
63Morphine addiction_Homo sapiens_hsa050320.90584384
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90464576
65Long-term depression_Homo sapiens_hsa047300.89648767
66Autoimmune thyroid disease_Homo sapiens_hsa053200.89404413
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88361263
68Ribosome_Homo sapiens_hsa030100.87786505
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87595540
70Parkinsons disease_Homo sapiens_hsa050120.87174552
71Insulin secretion_Homo sapiens_hsa049110.86862325
72Long-term potentiation_Homo sapiens_hsa047200.85404906
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83880994
74Steroid biosynthesis_Homo sapiens_hsa001000.83863281
75Primary immunodeficiency_Homo sapiens_hsa053400.83281924
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83120238
77Fatty acid elongation_Homo sapiens_hsa000620.83017353
78T cell receptor signaling pathway_Homo sapiens_hsa046600.82618043
79Ovarian steroidogenesis_Homo sapiens_hsa049130.82245380
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78724566
81Calcium signaling pathway_Homo sapiens_hsa040200.77531654
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75583606
83Spliceosome_Homo sapiens_hsa030400.74882941
84ABC transporters_Homo sapiens_hsa020100.74699113
85Proteasome_Homo sapiens_hsa030500.74149176
86Herpes simplex infection_Homo sapiens_hsa051680.73989231
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71546655
88Lysine degradation_Homo sapiens_hsa003100.70526841
89One carbon pool by folate_Homo sapiens_hsa006700.70194255
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.69921086
91Type I diabetes mellitus_Homo sapiens_hsa049400.69634918
92Nucleotide excision repair_Homo sapiens_hsa034200.66762440
93Pyrimidine metabolism_Homo sapiens_hsa002400.65950173
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65292229
95B cell receptor signaling pathway_Homo sapiens_hsa046620.64731778
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64405321
97Ras signaling pathway_Homo sapiens_hsa040140.64302521
98Choline metabolism in cancer_Homo sapiens_hsa052310.63561967
99Measles_Homo sapiens_hsa051620.62814097
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61968748
101GABAergic synapse_Homo sapiens_hsa047270.61748071
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61488680
103Purine metabolism_Homo sapiens_hsa002300.61339105
104Epstein-Barr virus infection_Homo sapiens_hsa051690.60640308
105Oxytocin signaling pathway_Homo sapiens_hsa049210.59668504
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59004255
107Malaria_Homo sapiens_hsa051440.58903815
108p53 signaling pathway_Homo sapiens_hsa041150.58756517
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58702452
110Amphetamine addiction_Homo sapiens_hsa050310.58697909
111Inositol phosphate metabolism_Homo sapiens_hsa005620.58686347
112Chemokine signaling pathway_Homo sapiens_hsa040620.57586743
113Base excision repair_Homo sapiens_hsa034100.57451910
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57029356
115Influenza A_Homo sapiens_hsa051640.56152503
116Pancreatic cancer_Homo sapiens_hsa052120.56067190
117Hedgehog signaling pathway_Homo sapiens_hsa043400.55836026
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54625322
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54568895
120cAMP signaling pathway_Homo sapiens_hsa040240.54517553
121Metabolic pathways_Homo sapiens_hsa011000.54350935
122DNA replication_Homo sapiens_hsa030300.54226193
123Renin secretion_Homo sapiens_hsa049240.53949691
124Leishmaniasis_Homo sapiens_hsa051400.52896463
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52686192
126Dopaminergic synapse_Homo sapiens_hsa047280.52292676
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52117388
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51893321
129Colorectal cancer_Homo sapiens_hsa052100.51704145
130Oocyte meiosis_Homo sapiens_hsa041140.50777385
131Protein export_Homo sapiens_hsa030600.50737409
132TNF signaling pathway_Homo sapiens_hsa046680.49747772
133Retinol metabolism_Homo sapiens_hsa008300.49216175
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.48686502
135Circadian entrainment_Homo sapiens_hsa047130.48663906
136MAPK signaling pathway_Homo sapiens_hsa040100.47896653
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.47705289
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47692473
139Synaptic vesicle cycle_Homo sapiens_hsa047210.46267482
140beta-Alanine metabolism_Homo sapiens_hsa004100.45151322
141Chemical carcinogenesis_Homo sapiens_hsa052040.41161502
142Salivary secretion_Homo sapiens_hsa049700.40979730
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40125079
144Wnt signaling pathway_Homo sapiens_hsa043100.38663040
145Sphingolipid metabolism_Homo sapiens_hsa006000.36093639
146FoxO signaling pathway_Homo sapiens_hsa040680.35068205
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33989379
148TGF-beta signaling pathway_Homo sapiens_hsa043500.31798307
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30855241
150Cholinergic synapse_Homo sapiens_hsa047250.28942819

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