CNOT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)5.84515276
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.21796234
3mitotic sister chromatid cohesion (GO:0007064)4.97682421
4nuclear pore organization (GO:0006999)4.61870370
5nuclear pore complex assembly (GO:0051292)4.44852793
6DNA unwinding involved in DNA replication (GO:0006268)4.38614669
7DNA topological change (GO:0006265)4.15694579
8protein localization to kinetochore (GO:0034501)3.95425935
9mitotic chromosome condensation (GO:0007076)3.94440423
10labyrinthine layer development (GO:0060711)3.84748472
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.82347000
12negative regulation of RNA splicing (GO:0033119)3.78911167
13sister chromatid segregation (GO:0000819)3.77941681
14mitotic metaphase plate congression (GO:0007080)3.72412327
15translesion synthesis (GO:0019985)3.65704145
16regulation of DNA endoreduplication (GO:0032875)3.61346042
17gastrulation with mouth forming second (GO:0001702)3.56949528
18alternative mRNA splicing, via spliceosome (GO:0000380)3.54398859
19negative regulation of histone acetylation (GO:0035067)3.51962231
20regulation of centrosome cycle (GO:0046605)3.48221272
21regulation of centriole replication (GO:0046599)3.47368929
22chromatin assembly (GO:0031497)3.43349936
23kinetochore organization (GO:0051383)3.39535053
24negative regulation of peptidyl-lysine acetylation (GO:2000757)3.38360866
25negative regulation of mRNA processing (GO:0050686)3.36588235
26dosage compensation (GO:0007549)3.33140192
27protein localization to chromosome, centromeric region (GO:0071459)3.31658683
28regulation of RNA export from nucleus (GO:0046831)3.31387095
29definitive hemopoiesis (GO:0060216)3.29898315
30regulation of centrosome duplication (GO:0010824)3.27809860
31pore complex assembly (GO:0046931)3.27778345
32negative regulation of histone methylation (GO:0031061)3.24776225
33centrosome localization (GO:0051642)3.22467345
34RNA stabilization (GO:0043489)3.22232242
35mRNA stabilization (GO:0048255)3.22232242
36heterochromatin organization (GO:0070828)3.21702866
37keratinocyte development (GO:0003334)3.21125710
38mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.17354202
39attachment of spindle microtubules to kinetochore (GO:0008608)3.10562715
40embryonic body morphogenesis (GO:0010172)3.08641228
41mitotic recombination (GO:0006312)3.07635678
42cytoplasmic mRNA processing body assembly (GO:0033962)3.05369056
43histone H3-K9 methylation (GO:0051567)3.04329203
44regulation of DNA methylation (GO:0044030)3.03999084
45mitotic sister chromatid segregation (GO:0000070)3.03703979
46chromatin assembly or disassembly (GO:0006333)3.02750965
47DNA duplex unwinding (GO:0032508)3.02440670
48regulation of histone H3-K9 methylation (GO:0051570)2.98617591
49glucocorticoid receptor signaling pathway (GO:0042921)2.98397511
50DNA geometric change (GO:0032392)2.98041591
51body morphogenesis (GO:0010171)2.97661588
52negative regulation of mRNA metabolic process (GO:1903312)2.97519542
53establishment of chromosome localization (GO:0051303)2.96971492
54endothelial tube morphogenesis (GO:0061154)2.96400745
55morphogenesis of an endothelium (GO:0003159)2.96400745
56pre-miRNA processing (GO:0031054)2.93089576
57histone H2A monoubiquitination (GO:0035518)2.91033501
58establishment of tissue polarity (GO:0007164)2.89899568
59establishment of planar polarity (GO:0001736)2.89899568
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89517397
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89517397
62positive regulation of mitotic sister chromatid separation (GO:1901970)2.89517397
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87096111
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.87096111
65regulation of translation, ncRNA-mediated (GO:0045974)2.87096111
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84224733
67peptidyl-lysine dimethylation (GO:0018027)2.83180058
68embryonic retina morphogenesis in camera-type eye (GO:0060059)2.80294379
69negative regulation of histone modification (GO:0031057)2.78238330
70mitotic nuclear envelope disassembly (GO:0007077)2.76864271
71histone H3-K36 demethylation (GO:0070544)2.75602605
72corticosteroid receptor signaling pathway (GO:0031958)2.75602136
73microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.74701802
74regulation of nucleobase-containing compound transport (GO:0032239)2.74055591
75protein localization to chromosome (GO:0034502)2.73962274
76nucleotide-excision repair, DNA gap filling (GO:0006297)2.73667918
77dorsal/ventral axis specification (GO:0009950)2.73559349
78telomere maintenance via semi-conservative replication (GO:0032201)2.73431788
79positive regulation of chromosome segregation (GO:0051984)2.73239970
80protein localization to cilium (GO:0061512)2.72686461
81negative regulation of DNA repair (GO:0045738)2.72476308
823-UTR-mediated mRNA stabilization (GO:0070935)2.72420789
83DNA strand elongation involved in DNA replication (GO:0006271)2.70746751
84regulation of mRNA stability (GO:0043488)2.70342029
85telomere maintenance via recombination (GO:0000722)2.69853088
86regulation of chromosome segregation (GO:0051983)2.68377952
87chromosome condensation (GO:0030261)2.67748554
88resolution of meiotic recombination intermediates (GO:0000712)2.67209555
89glial cell proliferation (GO:0014009)2.66025848
90genitalia morphogenesis (GO:0035112)2.65179031
91microtubule anchoring (GO:0034453)2.65039956
92DNA conformation change (GO:0071103)2.64941792
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.64876901
94histone exchange (GO:0043486)2.63821236
95ribosomal small subunit assembly (GO:0000028)2.63353374
96DNA replication-independent nucleosome organization (GO:0034724)2.62709131
97DNA replication-independent nucleosome assembly (GO:0006336)2.62709131
98histone mRNA catabolic process (GO:0071044)2.62305641
99membrane disassembly (GO:0030397)2.62212589
100nuclear envelope disassembly (GO:0051081)2.62212589
101pyrimidine nucleobase catabolic process (GO:0006208)2.61901341
102embryonic foregut morphogenesis (GO:0048617)2.61285180
103regulation of translational fidelity (GO:0006450)2.61073727
104spindle checkpoint (GO:0031577)2.60022345
105substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.59270049
106substrate-independent telencephalic tangential migration (GO:0021826)2.59270049
107meiotic chromosome segregation (GO:0045132)2.59072078
108regulation of cardioblast proliferation (GO:0003264)2.58930266
109regulation of secondary heart field cardioblast proliferation (GO:0003266)2.58930266
110negative regulation of protein acetylation (GO:1901984)2.58373231
111ATP-dependent chromatin remodeling (GO:0043044)2.57969457
112chromosome segregation (GO:0007059)2.56822323
113CENP-A containing nucleosome assembly (GO:0034080)2.56043098
114DNA strand elongation (GO:0022616)2.55295162
115metaphase plate congression (GO:0051310)2.55225573
116maturation of SSU-rRNA (GO:0030490)2.55137889
117synapsis (GO:0007129)2.54817489
118mRNA splice site selection (GO:0006376)2.54757277
119V(D)J recombination (GO:0033151)2.54530337
120regulation of heart morphogenesis (GO:2000826)2.52139995
121centriole assembly (GO:0098534)2.50710089
122regulation of RNA stability (GO:0043487)2.50400185
123negative regulation of chromatin modification (GO:1903309)2.50216553
124negative regulation of chromosome segregation (GO:0051985)2.49968204
125histone H3-K9 modification (GO:0061647)2.49510238
126negative regulation of B cell apoptotic process (GO:0002903)2.49116032
127SMAD protein complex assembly (GO:0007183)2.49111379
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48945774
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48945774
130sister chromatid cohesion (GO:0007062)2.48799661
131regulation of mitotic sister chromatid segregation (GO:0033047)2.48630546
132regulation of sister chromatid segregation (GO:0033045)2.48630546
133regulation of mitotic sister chromatid separation (GO:0010965)2.48630546
134chromatin remodeling at centromere (GO:0031055)2.46033452
135regulation of stem cell maintenance (GO:2000036)2.45647739
136* gene silencing by RNA (GO:0031047)2.45513401
137NLS-bearing protein import into nucleus (GO:0006607)2.45384482
138paraxial mesoderm development (GO:0048339)2.45185380
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.45126307
140negative regulation of sister chromatid segregation (GO:0033046)2.45126307
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.45126307
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.45126307
143negative regulation of mitotic sister chromatid segregation (GO:0033048)2.45126307
144postreplication repair (GO:0006301)2.43784861
145intraciliary transport (GO:0042073)2.43561240
146DNA packaging (GO:0006323)2.43219508
147establishment of mitotic spindle orientation (GO:0000132)2.43151871
148hippo signaling (GO:0035329)2.42310456
149mitotic spindle checkpoint (GO:0071174)2.41603849
150embryonic process involved in female pregnancy (GO:0060136)2.40275494
151regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.39774627
152apical protein localization (GO:0045176)2.39736713
153regulation of spindle organization (GO:0090224)2.38262949
154establishment of mitotic spindle localization (GO:0040001)2.37709816
155mitotic G2/M transition checkpoint (GO:0044818)2.37479801
156mitotic spindle assembly checkpoint (GO:0007094)2.35179418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.26245989
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.98239819
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.36060485
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61420620
5EZH2_22144423_ChIP-Seq_EOC_Human3.60197237
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35263073
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14182398
8MYC_22102868_ChIP-Seq_BL_Human2.94784637
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89292756
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56528735
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.52849461
12AR_21909140_ChIP-Seq_LNCAP_Human2.45878626
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44306986
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.40285886
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.39628173
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36426415
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34257506
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31640241
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14257896
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.13169488
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10926649
22FUS_26573619_Chip-Seq_HEK293_Human2.01108281
23E2F7_22180533_ChIP-Seq_HELA_Human10.7062724
24* TCF7_22412390_ChIP-Seq_EML_Mouse1.86038447
25SCL_19346495_ChIP-Seq_HPC-7_Human1.80291722
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77020735
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75642328
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75344851
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69442299
30VDR_21846776_ChIP-Seq_THP-1_Human1.66746571
31IGF1R_20145208_ChIP-Seq_DFB_Human1.65564533
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63524829
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62479118
34VDR_22108803_ChIP-Seq_LS180_Human1.60532100
35IRF1_19129219_ChIP-ChIP_H3396_Human1.60215223
36CLOCK_20551151_ChIP-Seq_293T_Human1.59204705
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57227742
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56215128
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55655096
40MAF_26560356_Chip-Seq_TH1_Human1.54246611
41CIITA_25753668_ChIP-Seq_RAJI_Human1.53456663
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51643126
43MYB_26560356_Chip-Seq_TH2_Human1.49309571
44KDM2B_26808549_Chip-Seq_DND41_Human1.47010209
45UTX_26944678_Chip-Seq_JUKART_Human1.44875304
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.43006046
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.42874262
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42465916
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41606453
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41251904
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40520795
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40421256
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38191075
54* MYB_26560356_Chip-Seq_TH1_Human1.34098161
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33787541
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33086420
57CHD1_26751641_Chip-Seq_LNCaP_Human1.31246718
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.30067240
59KDM5A_27292631_Chip-Seq_BREAST_Human1.29756776
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29238908
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28138953
62VDR_24763502_ChIP-Seq_THP-1_Human1.27963436
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26221143
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24373274
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23793264
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22775095
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21981512
68XRN2_22483619_ChIP-Seq_HELA_Human1.20321053
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.20030995
70* NANOG_21062744_ChIP-ChIP_HESCs_Human1.19052707
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17997847
72EWS_26573619_Chip-Seq_HEK293_Human1.17852652
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17688346
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17043197
75RNF2_27304074_Chip-Seq_NSC_Mouse1.16170228
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15744483
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15721371
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14989347
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.13940874
80* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12806963
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.12774280
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09805679
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09520813
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09330133
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09318969
86* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08133569
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07176879
88* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06881748
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06324510
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06081107
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.05927664
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05357248
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05205397
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.05118973
95* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04860187
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04709588
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04458460
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04262328
99* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04023032
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03553856
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02828920
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01226758
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00212598
104ELK1_19687146_ChIP-ChIP_HELA_Human0.99377387
105* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98905917
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98697415
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98237853
108* SOX9_26525672_Chip-Seq_HEART_Mouse0.98004656
109POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.97961067
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97735476
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97448297
112REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97389703
113RUNX_20019798_ChIP-Seq_JUKART_Human0.97325173
114ZNF274_21170338_ChIP-Seq_K562_Hela0.97309366
115BRD4_25478319_ChIP-Seq_HGPS_Human0.96522096
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95604426
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94850025
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93034088
119* FOXP3_21729870_ChIP-Seq_TREG_Human0.92898181
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92195593
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92188580
122* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92183898
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91649335
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91341222
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91209587
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89958438
127NCOR1_26117541_ChIP-Seq_K562_Human0.89500539
128* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89083816
129ER_23166858_ChIP-Seq_MCF-7_Human0.88827657
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88694465
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.88121196
132P300_19829295_ChIP-Seq_ESCs_Human0.88069237
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87823154
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87684967
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87645692
136SMAD4_21799915_ChIP-Seq_A2780_Human0.86981083
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86399827
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86207636
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.85611947
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85593511
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84847115
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84673925
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84245205
144TAF15_26573619_Chip-Seq_HEK293_Human0.84237170
145MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84122516
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83985326
147TTF2_22483619_ChIP-Seq_HELA_Human0.83980538
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83750625
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83693921
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83693921
151EZH2_27304074_Chip-Seq_ESCs_Mouse0.83060246
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83001565
153POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82323915
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81680504
155SPI1_23547873_ChIP-Seq_NB4_Human0.81629488
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80853254
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80853254
158STAT3_23295773_ChIP-Seq_U87_Human0.78531441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.66763957
2MP0006054_spinal_hemorrhage3.47721128
3MP0010234_abnormal_vibrissa_follicle3.25985494
4MP0008789_abnormal_olfactory_epithelium2.66102255
5MP0005394_taste/olfaction_phenotype2.56557013
6MP0005499_abnormal_olfactory_system2.56557013
7MP0010094_abnormal_chromosome_stability2.44668107
8MP0009278_abnormal_bone_marrow2.42169823
9MP0010352_gastrointestinal_tract_polyps2.36795006
10MP0004808_abnormal_hematopoietic_stem2.30965861
11MP0008007_abnormal_cellular_replicative2.25735100
12MP0004957_abnormal_blastocyst_morpholog2.24637745
13MP0003111_abnormal_nucleus_morphology2.24279854
14MP0003121_genomic_imprinting2.18046599
15MP0009379_abnormal_foot_pigmentation2.16601702
16MP0000537_abnormal_urethra_morphology2.13783037
17MP0003567_abnormal_fetal_cardiomyocyte2.12532248
18MP0008877_abnormal_DNA_methylation2.12302773
19MP0005076_abnormal_cell_differentiation2.12147679
20MP0000569_abnormal_digit_pigmentation2.05914618
21MP0003077_abnormal_cell_cycle2.03950421
22MP0008057_abnormal_DNA_replication2.03622761
23MP0003693_abnormal_embryo_hatching2.02212342
24MP0002396_abnormal_hematopoietic_system1.93600866
25MP0003705_abnormal_hypodermis_morpholog1.89966717
26MP0003300_gastrointestinal_ulcer1.86780679
27MP0002233_abnormal_nose_morphology1.86305743
28MP0000778_abnormal_nervous_system1.85219212
29MP0000566_synostosis1.85175378
30MP0003718_maternal_effect1.82450605
31MP0005248_abnormal_Harderian_gland1.76396102
32MP0003123_paternal_imprinting1.75625722
33MP0003890_abnormal_embryonic-extraembry1.73672726
34MP0010307_abnormal_tumor_latency1.68988778
35MP0001545_abnormal_hematopoietic_system1.61653064
36MP0005397_hematopoietic_system_phenotyp1.61653064
37MP0004197_abnormal_fetal_growth/weight/1.54591241
38MP0010678_abnormal_skin_adnexa1.52217457
39MP0002086_abnormal_extraembryonic_tissu1.51106495
40MP0000350_abnormal_cell_proliferation1.50398632
41MP0010030_abnormal_orbit_morphology1.50302033
42MP0001188_hyperpigmentation1.48778992
43MP0000733_abnormal_muscle_development1.48670319
44MP0000490_abnormal_crypts_of1.46392342
45MP0001879_abnormal_lymphatic_vessel1.45381567
46MP0001697_abnormal_embryo_size1.43354798
47MP0003861_abnormal_nervous_system1.42070191
48MP0002088_abnormal_embryonic_growth/wei1.42011740
49MP0003984_embryonic_growth_retardation1.41682315
50MP0000049_abnormal_middle_ear1.41554277
51MP0005380_embryogenesis_phenotype1.41480168
52MP0001672_abnormal_embryogenesis/_devel1.41480168
53MP0000427_abnormal_hair_cycle1.41273475
54MP0009053_abnormal_anal_canal1.41227450
55MP0001529_abnormal_vocalization1.41172038
56MP0003943_abnormal_hepatobiliary_system1.40871098
57MP0002938_white_spotting1.39474304
58MP0002163_abnormal_gland_morphology1.36824304
59MP0002166_altered_tumor_susceptibility1.36809967
60MP0001915_intracranial_hemorrhage1.36403151
61MP0002084_abnormal_developmental_patter1.36379937
62MP0001730_embryonic_growth_arrest1.34560779
63MP0005187_abnormal_penis_morphology1.34333389
64MP0001849_ear_inflammation1.32082787
65MP0002234_abnormal_pharynx_morphology1.30138440
66MP0005409_darkened_coat_color1.28542000
67MP0002085_abnormal_embryonic_tissue1.27650837
68MP0002282_abnormal_trachea_morphology1.27486128
69MP0000703_abnormal_thymus_morphology1.24838640
70MP0003115_abnormal_respiratory_system1.24613996
71MP0003303_peritoneal_inflammation1.24195875
72MP0002102_abnormal_ear_morphology1.21136887
73MP0003315_abnormal_perineum_morphology1.20396638
74MP0003122_maternal_imprinting1.18724025
75MP0003763_abnormal_thymus_physiology1.18688899
76MP0000465_gastrointestinal_hemorrhage1.17880373
77MP0003935_abnormal_craniofacial_develop1.17816802
78MP0009672_abnormal_birth_weight1.17697806
79MP0002210_abnormal_sex_determination1.17287336
80MP0003937_abnormal_limbs/digits/tail_de1.15632900
81MP0000383_abnormal_hair_follicle1.15335606
82MP0002092_abnormal_eye_morphology1.11060557
83MP0004185_abnormal_adipocyte_glucose1.10754511
84MP0009703_decreased_birth_body1.10438106
85MP0008932_abnormal_embryonic_tissue1.09596765
86MP0002006_tumorigenesis1.09468403
87MP0002080_prenatal_lethality1.08728533
88MP0000428_abnormal_craniofacial_morphol1.08257942
89MP0002398_abnormal_bone_marrow1.08060696
90MP0002009_preneoplasia1.06652848
91MP0002697_abnormal_eye_size1.06322073
92MP0004264_abnormal_extraembryonic_tissu1.05870024
93MP0002160_abnormal_reproductive_system1.04595604
94MP0010368_abnormal_lymphatic_system1.03565686
95MP0002925_abnormal_cardiovascular_devel1.02156779
96MP0003942_abnormal_urinary_system1.01016120
97MP0001293_anophthalmia1.00397949
98MP0000647_abnormal_sebaceous_gland0.99612314
99MP0003385_abnormal_body_wall0.96277593
100MP0000631_abnormal_neuroendocrine_gland0.95198323
101MP0006276_abnormal_autonomic_nervous0.94445411
102MP0002184_abnormal_innervation0.94344408
103MP0002095_abnormal_skin_pigmentation0.93729080
104MP0002932_abnormal_joint_morphology0.93317012
105MP0003283_abnormal_digestive_organ0.92982689
106MP0002249_abnormal_larynx_morphology0.92183730
107MP0002081_perinatal_lethality0.91284450
108MP0001346_abnormal_lacrimal_gland0.90901839
109MP0005623_abnormal_meninges_morphology0.90408211
110MP0001145_abnormal_male_reproductive0.90259050
111MP0002877_abnormal_melanocyte_morpholog0.90061801
112MP0000579_abnormal_nail_morphology0.89869663
113MP0002152_abnormal_brain_morphology0.88684824
114MP0001929_abnormal_gametogenesis0.88620250
115MP0002019_abnormal_tumor_incidence0.87840709
116MP0002722_abnormal_immune_system0.87453403
117MP0002751_abnormal_autonomic_nervous0.86325191
118MP0008961_abnormal_basal_metabolism0.86217333
119MP0001286_abnormal_eye_development0.84411053
120MP0008058_abnormal_DNA_repair0.84339112
121MP0000955_abnormal_spinal_cord0.84318657
122MP0002098_abnormal_vibrissa_morphology0.83540233
123MP0002116_abnormal_craniofacial_bone0.83513323
124MP0000432_abnormal_head_morphology0.83181857
125MP0005174_abnormal_tail_pigmentation0.83057017
126MP0000653_abnormal_sex_gland0.82906691
127MP0003787_abnormal_imprinting0.82512340
128MP0000685_abnormal_immune_system0.81272744
129MP0003755_abnormal_palate_morphology0.80667022
130MP0002111_abnormal_tail_morphology0.79692677
131MP0005220_abnormal_exocrine_pancreas0.79207425
132MP0003119_abnormal_digestive_system0.77319594
133MP0001340_abnormal_eyelid_morphology0.76690581
134MP0000762_abnormal_tongue_morphology0.75937596
135MP0001784_abnormal_fluid_regulation0.75164527
136MP0005391_vision/eye_phenotype0.75018330
137MP0006035_abnormal_mitochondrial_morpho0.74265087
138MP0000377_abnormal_hair_follicle0.74263669
139MP0000689_abnormal_spleen_morphology0.74095570
140MP0003938_abnormal_ear_development0.74009214
141MP0010155_abnormal_intestine_physiology0.73496263
142MP0002429_abnormal_blood_cell0.72404757
143MP0000767_abnormal_smooth_muscle0.71026403
144MP0009333_abnormal_splenocyte_physiolog0.71013729
145MP0000313_abnormal_cell_death0.70944639
146MP0000477_abnormal_intestine_morphology0.70839968
147MP0004272_abnormal_basement_membrane0.70557907

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.12252124
2Volvulus (HP:0002580)3.96170650
3Neoplasm of the adrenal cortex (HP:0100641)3.82397252
4Germ cell neoplasia (HP:0100728)3.65771936
5Diastasis recti (HP:0001540)3.44997852
6Subacute progressive viral hepatitis (HP:0006572)3.40319710
7Increased nuchal translucency (HP:0010880)3.34289765
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32954877
9Short 4th metacarpal (HP:0010044)3.32954877
10Abnormal pancreas size (HP:0012094)2.97813326
11Nephroblastoma (Wilms tumor) (HP:0002667)2.87946837
12Septo-optic dysplasia (HP:0100842)2.81050576
13Hyperacusis (HP:0010780)2.78371207
14High anterior hairline (HP:0009890)2.75842868
15Deep philtrum (HP:0002002)2.73665118
16Embryonal renal neoplasm (HP:0011794)2.73180648
17Abnormality of the fingertips (HP:0001211)2.66354738
18Acute myeloid leukemia (HP:0004808)2.65631412
19Rectal prolapse (HP:0002035)2.64665238
20Abnormality of the 4th metacarpal (HP:0010012)2.60129629
21Renal duplication (HP:0000075)2.55826576
22Neonatal hypoglycemia (HP:0001998)2.54849384
23Missing ribs (HP:0000921)2.52480447
24Cortical dysplasia (HP:0002539)2.47534963
25Asymmetry of the thorax (HP:0001555)2.45745483
26Proximal placement of thumb (HP:0009623)2.44197259
27Renovascular hypertension (HP:0100817)2.38402102
28Cutis marmorata (HP:0000965)2.38152163
29Deviation of the thumb (HP:0009603)2.36077733
30Overgrowth (HP:0001548)2.34630593
31Facial hemangioma (HP:0000329)2.32186873
32Elfin facies (HP:0004428)2.31417616
33Skull defect (HP:0001362)2.31274832
3411 pairs of ribs (HP:0000878)2.31126911
35Abnormality of the labia minora (HP:0012880)2.30032174
36Malignant gastrointestinal tract tumors (HP:0006749)2.21487243
37Gastrointestinal carcinoma (HP:0002672)2.21487243
38Viral hepatitis (HP:0006562)2.20982513
39Vertebral arch anomaly (HP:0008438)2.20006436
40Colon cancer (HP:0003003)2.19673369
41Abnormality of chromosome segregation (HP:0002916)2.17999614
42Narrow palate (HP:0000189)2.15389245
43Papillary thyroid carcinoma (HP:0002895)2.14744680
44Obsessive-compulsive behavior (HP:0000722)2.11465572
45Lissencephaly (HP:0001339)2.11059860
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.06945083
47Long eyelashes (HP:0000527)2.05005572
48Ectopic kidney (HP:0000086)2.04227086
49Abnormality of the septum pellucidum (HP:0007375)2.03243563
50Overriding aorta (HP:0002623)2.03024652
51Increased density of long bones (HP:0006392)2.02630617
52Enlarged penis (HP:0000040)2.02300401
53Transitional cell carcinoma of the bladder (HP:0006740)2.02057999
54High pitched voice (HP:0001620)2.01469367
55Absent septum pellucidum (HP:0001331)1.98242982
56Rhabdomyosarcoma (HP:0002859)1.97906030
57Abnormality of the phalanges of the hallux (HP:0010057)1.97373589
58Chorioretinal atrophy (HP:0000533)1.96938764
59Leiomyosarcoma (HP:0100243)1.95832360
60Uterine leiomyosarcoma (HP:0002891)1.95832360
61Spinal cord lesions (HP:0100561)1.94066707
62Syringomyelia (HP:0003396)1.94066707
63Pointed chin (HP:0000307)1.93785219
64Reticulocytopenia (HP:0001896)1.93643851
65Abnormality of chromosome stability (HP:0003220)1.93295690
66Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93117644
67Embryonal neoplasm (HP:0002898)1.92503023
68Hematochezia (HP:0002573)1.92312000
69Osteomalacia (HP:0002749)1.91173729
70Low anterior hairline (HP:0000294)1.87939889
71Supernumerary spleens (HP:0009799)1.87857775
72Long foot (HP:0001833)1.87507166
73Capillary hemangiomas (HP:0005306)1.87319450
74T lymphocytopenia (HP:0005403)1.86358731
75Hypoplastic labia majora (HP:0000059)1.85578183
76Micronodular cirrhosis (HP:0001413)1.85097367
77Drooling (HP:0002307)1.84584909
78Curly hair (HP:0002212)1.84454506
79Shallow orbits (HP:0000586)1.82055090
80Macroorchidism (HP:0000053)1.81618390
81Oligodactyly (HP:0012165)1.81486816
82Abnormality of the peritoneum (HP:0002585)1.80794758
83Bladder carcinoma (HP:0002862)1.80326250
84Bladder neoplasm (HP:0009725)1.80326250
85Adrenal hypoplasia (HP:0000835)1.80234378
86Termporal pattern (HP:0011008)1.79904813
87Insidious onset (HP:0003587)1.79904813
88Midline defect of the nose (HP:0004122)1.79899034
89Abnormality of the carotid arteries (HP:0005344)1.78427862
90Sandal gap (HP:0001852)1.78377772
91Abnormality of T cell number (HP:0011839)1.77244634
92Myelodysplasia (HP:0002863)1.76851998
93Bowel diverticulosis (HP:0005222)1.75215751
94Cystic hygroma (HP:0000476)1.75208697
95Partial agenesis of the corpus callosum (HP:0001338)1.74838723
96Preaxial hand polydactyly (HP:0001177)1.73161183
97Spastic diplegia (HP:0001264)1.72782150
98Small intestinal stenosis (HP:0012848)1.72495718
99Duodenal stenosis (HP:0100867)1.72495718
100Abnormality of the ileum (HP:0001549)1.71993751
101Patellar aplasia (HP:0006443)1.71924425
102Atresia of the external auditory canal (HP:0000413)1.71473104
103Septate vagina (HP:0001153)1.71322605
104Chromsome breakage (HP:0040012)1.71059032
105Absent eyebrow (HP:0002223)1.70441711
106Abdominal situs inversus (HP:0003363)1.69980818
107Abnormality of abdominal situs (HP:0011620)1.69980818
108Hallux valgus (HP:0001822)1.69833480
109Thrombocytosis (HP:0001894)1.69610068
110Prominent nose (HP:0000448)1.69194136
111Broad palm (HP:0001169)1.69167421
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68253208
113Microglossia (HP:0000171)1.67714082
114Thyroid carcinoma (HP:0002890)1.67341155
115Bifid tongue (HP:0010297)1.67137717
116Deviation of the hallux (HP:0010051)1.67017158
117Meckel diverticulum (HP:0002245)1.66975402
118Optic nerve hypoplasia (HP:0000609)1.66148246
119Oligodactyly (hands) (HP:0001180)1.65450222
120Neoplasm of the liver (HP:0002896)1.65034677
121Median cleft lip (HP:0000161)1.65014888
122Abnormal lung lobation (HP:0002101)1.63940900
123Abnormality of the preputium (HP:0100587)1.63384120
124Flat cornea (HP:0007720)1.62486507
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.62446207
126Triphalangeal thumb (HP:0001199)1.62353743
127Truncal obesity (HP:0001956)1.62309275
128Intestinal polyposis (HP:0200008)1.62134309
129Blepharitis (HP:0000498)1.61996077
130Recurrent viral infections (HP:0004429)1.61948664
131Abnormality of the labia majora (HP:0012881)1.61808519
132Facial cleft (HP:0002006)1.61748237
133Intestinal polyp (HP:0005266)1.61419602
134Heterotopia (HP:0002282)1.60862693
135Cafe-au-lait spot (HP:0000957)1.60713018
136Wide intermamillary distance (HP:0006610)1.60143294
137Cerebellar dysplasia (HP:0007033)1.59255117
138Overlapping toe (HP:0001845)1.59093152
139Skin tags (HP:0010609)1.58584028
140Advanced eruption of teeth (HP:0006288)1.58210512
141Exostoses (HP:0100777)1.58068688
142Tubulointerstitial nephritis (HP:0001970)1.58047232
143Breast carcinoma (HP:0003002)1.57856081
144Excessive salivation (HP:0003781)1.57767254
145Cutaneous finger syndactyly (HP:0010554)1.57318172
146Hypoplastic toenails (HP:0001800)1.57082819
147Large earlobe (HP:0009748)1.56882243
148Selective tooth agenesis (HP:0001592)1.56697911
149Micropenis (HP:0000054)1.56189411
150Pendular nystagmus (HP:0012043)1.55424985
151Dandy-Walker malformation (HP:0001305)1.54739847
152Aplasia/Hypoplasia of the patella (HP:0006498)1.54246585
153Cerebral aneurysm (HP:0004944)1.54066672
154Abnormality of hair growth rate (HP:0011363)1.53617725
155Slow-growing hair (HP:0002217)1.53617725
156Uterine neoplasm (HP:0010784)1.53587131
157Bicuspid aortic valve (HP:0001647)1.53462073
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.52524105
159Polymicrogyria (HP:0002126)1.52407861
160Insomnia (HP:0100785)1.52172600
161Rib fusion (HP:0000902)1.51907385
162Abnormal number of incisors (HP:0011064)1.51792583
163Abnormal hair whorl (HP:0010721)1.51443900
164Sloping forehead (HP:0000340)1.50806453
165Poor coordination (HP:0002370)1.50573013
166Maternal diabetes (HP:0009800)1.50224487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.92947488
2MKNK23.25922395
3MKNK13.06682730
4CDC72.98996894
5NEK22.85398385
6EEF2K2.84164210
7MAP3K102.79480850
8PKN22.66656996
9CASK2.62822720
10PBK2.55891560
11PLK42.48039721
12CDK62.38992177
13NEK12.36506534
14BCR2.34571037
15PTK62.29238999
16PNCK2.16294926
17STK242.11114819
18CDK122.08629179
19TRIB32.06828636
20WEE11.89536132
21SRPK11.84968947
22TAF11.81131867
23RIPK11.77957459
24STK101.74138821
25TYRO31.73012520
26TGFBR11.72020413
27BRSK21.71441184
28PAK41.63246694
29SCYL21.62279911
30TRIM281.61457210
31EIF2AK11.57468252
32LATS11.54763911
33TNIK1.54341872
34RPS6KB21.49827820
35RPS6KA41.49189455
36EPHB21.47536461
37CDK41.46574429
38BUB11.46133089
39LRRK21.41928542
40STK31.41714417
41PASK1.39124534
42DMPK1.36388842
43KSR11.34256605
44SIK11.31203063
45SIK21.30116510
46MAP3K41.30041057
47ATR1.25930287
48TTK1.23724529
49PDGFRA1.22261514
50CSNK1A1L1.19880803
51MELK1.16601416
52ALK1.16253643
53NME11.15928829
54ERBB31.15428924
55MAP2K71.13962143
56BRAF1.13009740
57PRKG21.12439031
58AURKB1.11857439
59STK391.10870329
60JAK31.06804468
61ACVR1B1.05532555
62DYRK31.05217135
63BRD41.04666221
64DYRK1B1.03685973
65STK38L1.03287442
66FGFR31.02860117
67LMTK21.02516135
68CLK11.01791103
69PDGFRB0.99904153
70MAP4K10.99861090
71ATM0.99361618
72CHEK10.95011399
73HIPK20.93288020
74CHUK0.91195663
75TGFBR20.89386785
76BTK0.87375085
77RPS6KB10.86338046
78MINK10.84169840
79SMG10.82743200
80CDK70.82511240
81STK40.80918138
82STK160.80779930
83MAP3K80.80530633
84MAP3K60.80502309
85SGK20.79054400
86ERBB20.76817439
87BRSK10.76259853
88NTRK10.75907769
89CDK80.75358340
90CSNK1G10.75188369
91RAF10.74166812
92WNK40.74023136
93MET0.73421418
94PLK10.72966776
95SGK30.72501683
96PIM10.71705281
97WNK30.70973697
98CHEK20.70549795
99MAP2K40.69956116
100CSNK1G30.69334322
101NLK0.68791193
102MTOR0.68777342
103PLK20.67978685
104MARK10.67670196
105FRK0.67507492
106FGFR20.67239553
107CSNK1E0.66926329
108BMPR1B0.66087402
109PIK3CA0.66078358
110TIE10.65642174
111CAMK1G0.63663580
112CDK90.63109571
113AURKA0.62566458
114ITK0.62346123
115YES10.61275265
116CDK20.61211842
117EPHA20.60456105
118DYRK20.59227656
119LATS20.58874000
120PLK30.58694104
121PRKCI0.58640934
122EIF2AK30.58433202
123NUAK10.57659634
124MAP3K70.57505134
125FGFR10.57249944
126PAK20.57112893
127NTRK20.56810851
128CDK10.53291867
129ARAF0.52940158
130TTN0.52855729
131FLT30.51618795
132CDK30.51566098
133NEK90.50502944
134MARK30.50323675
135CSF1R0.47668161
136WNK10.47282024
137TSSK60.46659862
138TXK0.45502285
139AKT20.43963175
140AKT10.43567864
141PRKDC0.42246937
142SGK4940.41435110
143SGK2230.41435110
144CAMK1D0.40946544
145CSNK1D0.40843735
146ICK0.40484549
147MAPK140.39577976
148CSNK1G20.38548349
149FER0.38513195
150TRPM70.36408420
151ILK0.35652988
152BMX0.34740310

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.12842822
2Cell cycle_Homo sapiens_hsa041102.51886845
3Mismatch repair_Homo sapiens_hsa034302.39961616
4Basal transcription factors_Homo sapiens_hsa030222.20014616
5Spliceosome_Homo sapiens_hsa030402.14857403
6Small cell lung cancer_Homo sapiens_hsa052221.90910361
7Base excision repair_Homo sapiens_hsa034101.88699971
8Chronic myeloid leukemia_Homo sapiens_hsa052201.83078060
9MicroRNAs in cancer_Homo sapiens_hsa052061.81062131
10Lysine degradation_Homo sapiens_hsa003101.73093489
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72210052
12mRNA surveillance pathway_Homo sapiens_hsa030151.71210164
13Fanconi anemia pathway_Homo sapiens_hsa034601.69093294
14Steroid biosynthesis_Homo sapiens_hsa001001.67574843
15RNA transport_Homo sapiens_hsa030131.65848733
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65462720
17Adherens junction_Homo sapiens_hsa045201.56879486
18Colorectal cancer_Homo sapiens_hsa052101.56556720
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48359918
20HTLV-I infection_Homo sapiens_hsa051661.41615119
21Herpes simplex infection_Homo sapiens_hsa051681.38296192
22Primary immunodeficiency_Homo sapiens_hsa053401.37963651
23p53 signaling pathway_Homo sapiens_hsa041151.33978485
24Basal cell carcinoma_Homo sapiens_hsa052171.33369124
25Viral carcinogenesis_Homo sapiens_hsa052031.32713145
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32380339
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31886421
28Nucleotide excision repair_Homo sapiens_hsa034201.30494682
29Homologous recombination_Homo sapiens_hsa034401.29801513
30Endometrial cancer_Homo sapiens_hsa052131.28529627
31Prostate cancer_Homo sapiens_hsa052151.26513338
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25960049
33Viral myocarditis_Homo sapiens_hsa054161.25402625
34Hepatitis B_Homo sapiens_hsa051611.23842427
35One carbon pool by folate_Homo sapiens_hsa006701.22510640
36Pancreatic cancer_Homo sapiens_hsa052121.20873569
37Antigen processing and presentation_Homo sapiens_hsa046121.20775335
38Axon guidance_Homo sapiens_hsa043601.20576994
39Measles_Homo sapiens_hsa051621.20028275
40Thyroid cancer_Homo sapiens_hsa052161.19613150
41Hippo signaling pathway_Homo sapiens_hsa043901.19384893
42TGF-beta signaling pathway_Homo sapiens_hsa043501.19028763
43Proteoglycans in cancer_Homo sapiens_hsa052051.17427738
44ErbB signaling pathway_Homo sapiens_hsa040121.17365326
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.15024547
46Non-homologous end-joining_Homo sapiens_hsa034501.13856930
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.13619450
48B cell receptor signaling pathway_Homo sapiens_hsa046621.13454621
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11972641
50Notch signaling pathway_Homo sapiens_hsa043301.10737239
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09449719
52Non-small cell lung cancer_Homo sapiens_hsa052231.09280554
53Focal adhesion_Homo sapiens_hsa045101.08965077
54T cell receptor signaling pathway_Homo sapiens_hsa046601.02846875
55Protein export_Homo sapiens_hsa030601.01352752
56mTOR signaling pathway_Homo sapiens_hsa041501.00655719
57Acute myeloid leukemia_Homo sapiens_hsa052210.99918898
58Platelet activation_Homo sapiens_hsa046110.97774911
59* RNA degradation_Homo sapiens_hsa030180.97502264
60Toxoplasmosis_Homo sapiens_hsa051450.96163706
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95574328
62Wnt signaling pathway_Homo sapiens_hsa043100.94297758
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94216907
64ECM-receptor interaction_Homo sapiens_hsa045120.93263299
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.92282600
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.92125430
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91727858
68Phototransduction_Homo sapiens_hsa047440.91512646
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91463411
70Pathways in cancer_Homo sapiens_hsa052000.90102434
71Tight junction_Homo sapiens_hsa045300.89712590
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88623029
73Choline metabolism in cancer_Homo sapiens_hsa052310.86628460
74Osteoclast differentiation_Homo sapiens_hsa043800.86546873
75Prolactin signaling pathway_Homo sapiens_hsa049170.85219763
76Oocyte meiosis_Homo sapiens_hsa041140.85026222
77FoxO signaling pathway_Homo sapiens_hsa040680.84255412
78Leishmaniasis_Homo sapiens_hsa051400.83121804
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83115511
80Melanoma_Homo sapiens_hsa052180.82928998
81Melanogenesis_Homo sapiens_hsa049160.82203085
82Inositol phosphate metabolism_Homo sapiens_hsa005620.82108249
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80477710
84Epstein-Barr virus infection_Homo sapiens_hsa051690.77693523
85Gap junction_Homo sapiens_hsa045400.77250457
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74693686
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74392168
88Hematopoietic cell lineage_Homo sapiens_hsa046400.73440885
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73378314
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.72382755
91Influenza A_Homo sapiens_hsa051640.72175729
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71944343
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71263226
94TNF signaling pathway_Homo sapiens_hsa046680.71137594
95Systemic lupus erythematosus_Homo sapiens_hsa053220.70886662
96Glioma_Homo sapiens_hsa052140.70286361
97Amoebiasis_Homo sapiens_hsa051460.70016912
98Chemokine signaling pathway_Homo sapiens_hsa040620.69365121
99Nicotine addiction_Homo sapiens_hsa050330.69094838
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.68913972
101Selenocompound metabolism_Homo sapiens_hsa004500.68490126
102Hedgehog signaling pathway_Homo sapiens_hsa043400.68096422
103Apoptosis_Homo sapiens_hsa042100.67780436
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67153259
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66600922
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66394762
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64284056
108Renal cell carcinoma_Homo sapiens_hsa052110.63727083
109Ribosome_Homo sapiens_hsa030100.63375181
110RNA polymerase_Homo sapiens_hsa030200.62252606
111N-Glycan biosynthesis_Homo sapiens_hsa005100.60024425
112Legionellosis_Homo sapiens_hsa051340.59875316
113Dorso-ventral axis formation_Homo sapiens_hsa043200.58079975
114Shigellosis_Homo sapiens_hsa051310.57875643
115Bladder cancer_Homo sapiens_hsa052190.57100329
116Pyrimidine metabolism_Homo sapiens_hsa002400.56891279
117Dopaminergic synapse_Homo sapiens_hsa047280.55806429
118Propanoate metabolism_Homo sapiens_hsa006400.55305892
119Insulin resistance_Homo sapiens_hsa049310.55249318
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.54434290
121HIF-1 signaling pathway_Homo sapiens_hsa040660.53540296
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53534186
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51314821
124Rap1 signaling pathway_Homo sapiens_hsa040150.50736126
125Circadian rhythm_Homo sapiens_hsa047100.49328723
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48770129
127Long-term potentiation_Homo sapiens_hsa047200.48316786
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48308247
129VEGF signaling pathway_Homo sapiens_hsa043700.47499638
130Long-term depression_Homo sapiens_hsa047300.47017745
131Insulin signaling pathway_Homo sapiens_hsa049100.46589681
132AMPK signaling pathway_Homo sapiens_hsa041520.45573185
133Cholinergic synapse_Homo sapiens_hsa047250.44866381
134Ras signaling pathway_Homo sapiens_hsa040140.44642031
135Glutamatergic synapse_Homo sapiens_hsa047240.43801497
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43593736
137Fatty acid biosynthesis_Homo sapiens_hsa000610.36980838
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34624349
139Cocaine addiction_Homo sapiens_hsa050300.32887457
140MAPK signaling pathway_Homo sapiens_hsa040100.28755844
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.28026989
142Estrogen signaling pathway_Homo sapiens_hsa049150.26937982
143Oxytocin signaling pathway_Homo sapiens_hsa049210.26471622

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